Complement C3 plays a critical role in periodontitis.However,its source,role and underlying mechanisms remain unclear.In our study,by analyzing single-cell sequencing data from mouse model of periodontitis,we identifi...Complement C3 plays a critical role in periodontitis.However,its source,role and underlying mechanisms remain unclear.In our study,by analyzing single-cell sequencing data from mouse model of periodontitis,we identified that C3 is primarily derived from periodontal fibroblasts.Subsequently,we demonstrated that C3a has a detrimental effect in ligature-induced periodontitis.C3ar−/−mice exhibited significantly less destruction of periodontal support tissues compared to wild-type mice,characterized by mild gingival tissue damage and reduced alveolar bone loss.This reduction was associated with decreased production of proinflammatory mediators and reduced osteoclast infiltration in the periodontal tissues.Mechanistic studies suggested that C3a could promote macrophage polarization and osteoclast differentiation.Finally,by analyzing single-cell sequencing data from the periodontal tissues of patients with periodontitis,we found that the results observed in mice were consistent with human data.Therefore,our findings clearly demonstrate the destructive role of fibroblast-derived C3 in ligature-induced periodontitis,driven by macrophage M1 polarization and osteoclast differentiation.These data strongly support the feasibility of C3a-targeted interventions for the treatment of human periodontitis.展开更多
Experiments on rock joint behaviors have shown that joint surface roughness is mobilized under shearing,inducing dilation and resulting in nonlinear joint shear strength and shear stress vs.shear displacement behavior...Experiments on rock joint behaviors have shown that joint surface roughness is mobilized under shearing,inducing dilation and resulting in nonlinear joint shear strength and shear stress vs.shear displacement behaviors.The Barton-Bandis(B-B) joint model provides the most realistic prediction for the nonlinear shear behavior of rock joints.The B-B model accounts for asperity roughness and strength through the joint roughness coefficient(JRC) and joint wall compressive strength(JCS) parameters.Nevertheless,many computer codes for rock engineering analysis still use the constant shear strength parameters from the linear Mohr-Coulomb(M-C) model,which is only appropriate for smooth and non-dilatant joints.This limitation prevents fractured rock models from capturing the nonlinearity of joint shear behavior.To bridge the B-B and the M C models,this paper aims to provide a linearized implementation of the B-B model using a tangential technique to obtain the equivalent M-C parameters that can satisfy the nonlinear shear behavior of rock joints.These equivalent parameters,namely the equivalent peak cohesion,friction angle,and dilation angle,are then converted into their mobilized forms to account for the mobilization and degradation of JRC under shearing.The conversion is done by expressing JRC in the equivalent peak parameters as functions of joint shear displacement using proposed hyperbolic and logarithmic functions at the pre-and post-peak regions of shear displacement,respectively.Likewise,the pre-and post-peak joint shear stiffnesses are derived so that a complete shear stress-shear displacement relationship can be established.Verifications of the linearized implementation of the B-B model show that the shear stress-shear displacement curves,the dilation behavior,and the shear strength envelopes of rock joints are consistent with available experimental and numerical results.展开更多
Three-dimensional atom probe （3DAP） technique has been used to study the nucleation and growth of M23C6 carbide in a supersaturated multi-component Fe-based alloy aged at 800℃. 3D images indicate that the radius of...Three-dimensional atom probe （3DAP） technique has been used to study the nucleation and growth of M23C6 carbide in a supersaturated multi-component Fe-based alloy aged at 800℃. 3D images indicate that the radius of M23C6 carbide after ageing for 10 min is about 9 nm. Concentration profiles of alloy elements in the carbide are also obtained. Combined with PANDAT and Thermo-Calc software, attempts to model the early stages of precipitation are present. The calculated particle size and composition of M23C6 carbide is in good agreement with 3DAP data.展开更多
In this paper, the existence, uniqueness, and asymptotic behavior of the solution of the density evolution equation for M/M/∞ model was studied by the semigroup theory of linear operators.
In this paper, we consider point spectra of the operator corresponding to the M/M/1 queueing model with working vacation and vacation interruption. We prove that the underlying operator has uncountable eigenvalues on ...In this paper, we consider point spectra of the operator corresponding to the M/M/1 queueing model with working vacation and vacation interruption. We prove that the underlying operator has uncountable eigenvalues on the left real line and these results describe the point spectra of the operator. Then, we show that the essential growth bound of the C_0-semigroup generated by the operator is 0 and therefore it is not quasi compact, the essential spectral bound of the C_0-semigroup is equal to 1. Moreover, our results imply it is impossible that the time-dependent solution of the model exponentially converges to its steady-state solution.展开更多
It is well known, in queueing theory, that the system performance is greatly influenced by scheduling policy. No universal optimum scheduling strategy exists in systems where individual customer service demands are no...It is well known, in queueing theory, that the system performance is greatly influenced by scheduling policy. No universal optimum scheduling strategy exists in systems where individual customer service demands are not known a priori. However, if the distribution of job times is known, then the residual time (expected time remaining for a job), based on the service it has already received, can be calculated. Our particular research contribution is in exploring the use of this function to enhance system performance by increasing the probability that a job will meet its deadline. In a detailed discrete event simulation, we have tested many different distributions with a wide range of C2 and shapes, as well as for single and dual processor system. Results of four distributions are reported here. We compare with RR and FCFS, and find that in all distributions studied our algorithm performs best. In the study of the use of two slow servers versus one fast server, we have discovered that they provide comparable performance, and in a few cases the double server system does better.展开更多
基金supported by the National Key R&D Program of China(No.2022YFC2504200)the National Natural Science Foundation of China(Nos.82370936,81920108012,82471032).
文摘Complement C3 plays a critical role in periodontitis.However,its source,role and underlying mechanisms remain unclear.In our study,by analyzing single-cell sequencing data from mouse model of periodontitis,we identified that C3 is primarily derived from periodontal fibroblasts.Subsequently,we demonstrated that C3a has a detrimental effect in ligature-induced periodontitis.C3ar−/−mice exhibited significantly less destruction of periodontal support tissues compared to wild-type mice,characterized by mild gingival tissue damage and reduced alveolar bone loss.This reduction was associated with decreased production of proinflammatory mediators and reduced osteoclast infiltration in the periodontal tissues.Mechanistic studies suggested that C3a could promote macrophage polarization and osteoclast differentiation.Finally,by analyzing single-cell sequencing data from the periodontal tissues of patients with periodontitis,we found that the results observed in mice were consistent with human data.Therefore,our findings clearly demonstrate the destructive role of fibroblast-derived C3 in ligature-induced periodontitis,driven by macrophage M1 polarization and osteoclast differentiation.These data strongly support the feasibility of C3a-targeted interventions for the treatment of human periodontitis.
基金support from the University Transportation Center for Underground Transportation Infrastructure at the Colorado School of Mines for partially funding this research under Grant No.69A3551747118 of the Fixing America's Surface Transportation Act(FAST Act) of U.S.DoT FY2016
文摘Experiments on rock joint behaviors have shown that joint surface roughness is mobilized under shearing,inducing dilation and resulting in nonlinear joint shear strength and shear stress vs.shear displacement behaviors.The Barton-Bandis(B-B) joint model provides the most realistic prediction for the nonlinear shear behavior of rock joints.The B-B model accounts for asperity roughness and strength through the joint roughness coefficient(JRC) and joint wall compressive strength(JCS) parameters.Nevertheless,many computer codes for rock engineering analysis still use the constant shear strength parameters from the linear Mohr-Coulomb(M-C) model,which is only appropriate for smooth and non-dilatant joints.This limitation prevents fractured rock models from capturing the nonlinearity of joint shear behavior.To bridge the B-B and the M C models,this paper aims to provide a linearized implementation of the B-B model using a tangential technique to obtain the equivalent M-C parameters that can satisfy the nonlinear shear behavior of rock joints.These equivalent parameters,namely the equivalent peak cohesion,friction angle,and dilation angle,are then converted into their mobilized forms to account for the mobilization and degradation of JRC under shearing.The conversion is done by expressing JRC in the equivalent peak parameters as functions of joint shear displacement using proposed hyperbolic and logarithmic functions at the pre-and post-peak regions of shear displacement,respectively.Likewise,the pre-and post-peak joint shear stiffnesses are derived so that a complete shear stress-shear displacement relationship can be established.Verifications of the linearized implementation of the B-B model show that the shear stress-shear displacement curves,the dilation behavior,and the shear strength envelopes of rock joints are consistent with available experimental and numerical results.
基金supported by the National Natural Science Foundation of China (Nos. 50971137 and 50934011)
文摘Three-dimensional atom probe （3DAP） technique has been used to study the nucleation and growth of M23C6 carbide in a supersaturated multi-component Fe-based alloy aged at 800℃. 3D images indicate that the radius of M23C6 carbide after ageing for 10 min is about 9 nm. Concentration profiles of alloy elements in the carbide are also obtained. Combined with PANDAT and Thermo-Calc software, attempts to model the early stages of precipitation are present. The calculated particle size and composition of M23C6 carbide is in good agreement with 3DAP data.
文摘In this paper, the existence, uniqueness, and asymptotic behavior of the solution of the density evolution equation for M/M/∞ model was studied by the semigroup theory of linear operators.
基金Supported by the National Natural Science Foundation of China(Grant No.11801485)
文摘In this paper, we consider point spectra of the operator corresponding to the M/M/1 queueing model with working vacation and vacation interruption. We prove that the underlying operator has uncountable eigenvalues on the left real line and these results describe the point spectra of the operator. Then, we show that the essential growth bound of the C_0-semigroup generated by the operator is 0 and therefore it is not quasi compact, the essential spectral bound of the C_0-semigroup is equal to 1. Moreover, our results imply it is impossible that the time-dependent solution of the model exponentially converges to its steady-state solution.
文摘It is well known, in queueing theory, that the system performance is greatly influenced by scheduling policy. No universal optimum scheduling strategy exists in systems where individual customer service demands are not known a priori. However, if the distribution of job times is known, then the residual time (expected time remaining for a job), based on the service it has already received, can be calculated. Our particular research contribution is in exploring the use of this function to enhance system performance by increasing the probability that a job will meet its deadline. In a detailed discrete event simulation, we have tested many different distributions with a wide range of C2 and shapes, as well as for single and dual processor system. Results of four distributions are reported here. We compare with RR and FCFS, and find that in all distributions studied our algorithm performs best. In the study of the use of two slow servers versus one fast server, we have discovered that they provide comparable performance, and in a few cases the double server system does better.
