The Eastern Sikkim area forming a part of the Lesser Himalaya is located between 27°10′～27°30′N latitudes and 88°25′～88°40′E longitudes (750km 2). The previous workers agreed that a domal str...The Eastern Sikkim area forming a part of the Lesser Himalaya is located between 27°10′～27°30′N latitudes and 88°25′～88°40′E longitudes (750km 2). The previous workers agreed that a domal structure is present in Sikkim which is constituted by low to high grade metamorphic rocks characterised by inverted metamorphism. The rocks were repeatedly deformed and were metamorphosed at about 550 to 770℃ (550 to 750MPa). Geologically, the oldest rocks of Eastern Sikkim are represented by Darjeeling Formation showing medium to high grade metamorphism. It is followed by low grade Daling Formation which is characterised by tectonic wedges of Lingtse gneiss. The potassic syenite intrusive i.e. the Sikkim igneous formation is youngest rock type of the area. The Darjeeling Formation associated with amphibolite bands consists of kyanite\|sillimanite, staurolite and garnet zones, while the Daling Formation is characterised by low grade chloritoid and chlorite zones. Lingtse Formation is gneissic in which patches of retrograded and sheared garnet schists are present. Intrusions of potassic syenites (Sikkim Formation) occur in the form of oval and concordant bodies. The F 1, F 2 and F 3 folds are well developed in rocks of Eastern Sikkim area.. The F 1 folds are rootless, tightly isoclinal or reclined and highly obliterated in their attitude. The F 2 folds belong to class IC of Ramsay (1967). Their interlimb angles vary from 20～50 degrees. Intersection lineation due to S 0/S 1 and S 2 surfaces is parallel to the F 2 folds axis. Third generation structures are represented by open to moderately tight and kinked folds. Superimposition of F 3 folds on F 2 folds resulted into type II interference pattern of Ramsay (1967). Structural analysis of these folds have revealed that F 2 folds are non\|cylindrical. The kink or F 3 folds were possibly responsible for the formation of a megakink resembling with the domal structure. The repeatedly deformed rocks of Eastern Sikkim area were folded, faulted, sheared/thrusted during the Himalayan orogeny. The Main Central Thrust (M C T) is actually a ductile shear zone and was subjected to imbrication during later phases of F 2 folding.展开更多
石膏样毛癣菌是导致家兔皮肤真菌病的主要病菌之一,它传播迅速,难以治愈,复发率高,给养兔产业造成了巨大的经济损失。本文对藏药A c. M的抗石膏样毛癣病药效进行了初步探索,并与常见的抗真菌中西药的药效进行了对比,结果表明A c. M对于...石膏样毛癣菌是导致家兔皮肤真菌病的主要病菌之一,它传播迅速,难以治愈,复发率高,给养兔产业造成了巨大的经济损失。本文对藏药A c. M的抗石膏样毛癣病药效进行了初步探索,并与常见的抗真菌中西药的药效进行了对比,结果表明A c. M对于石膏样毛癣病有较好的抑制作用。展开更多
One new Iriterpene saponin was isolated from Panaxjaponicus C. A. Meyer var major （Burk.） C. Y. Wu et K. M. Feng, and established as oleanolic acid 3-O-[β-D-glucopyranosyl-（1 →2）-β-D-glucuronopyranosyl-6＇-O-n-...One new Iriterpene saponin was isolated from Panaxjaponicus C. A. Meyer var major （Burk.） C. Y. Wu et K. M. Feng, and established as oleanolic acid 3-O-[β-D-glucopyranosyl-（1 →2）-β-D-glucuronopyranosyl-6＇-O-n-butyl ester] which showed mod- erate antitumor activities against the A2780 cells and OVCAR-3 cells. Its structure was established by means of spectral data, particularly NMR, including HSQC and HMBC techniques.展开更多
Due to France has suffered from many terrorist attacks and the number of visitors to the Louvre has gradually increased in recent years, a good evacuation plan for the Louvre is of vital significance. We use the minim...Due to France has suffered from many terrorist attacks and the number of visitors to the Louvre has gradually increased in recent years, a good evacuation plan for the Louvre is of vital significance. We use the minimization of the total evacuation time of all tourists as the optimization goal to find an optimal path. For conventional emergencies, a static model is built to evacuate visitors. And then we establish a nonlinear programming model. Using Lingo software, we get the distribution information of the visitors in different exhibition halls. For unconventional emergencies, we establish an adaptive dynamic model of tourist evacuation based on genetic algorithm. The sensitivity analysis of the model is considered by adding new paths. By solving the nonlinear programming problem with the double objective function of maximizing evacuation time and balancing the number of people in every path, we get the evacuation time last 1582.74 s. Finally, according to our result, we built mathematical models for the evacuation after an emergency and analyzed how to adapt and implement our models for other large and crowded structures.展开更多
Originated in the early 1990s, SCGM(1, m ) c model has enjoyed widespread application in the fields of urban planning, society economy prediction and modal control in recent years. However, none of these applications ...Originated in the early 1990s, SCGM(1, m ) c model has enjoyed widespread application in the fields of urban planning, society economy prediction and modal control in recent years. However, none of these applications have taken account of time lag effects in the modeling process. Aiming at overcoming the defect, the authors introduced time lag items into SCGM(1, m ) c model and developed a SCGM(1, m ) c model with time lag, then discusses in detail some principal problems in the model, such as parameters estimation, model verifying, model prediction, etc. The model was used on a real slope monitoring project and compared with the conventional SCGM(1, m ) c model. The results show an improvement of average models precision from 1.321 to 0.238 and total average of relative prediction errors from 12.41% to 7.98% when the modeling data length ranges from 29 to 48 in the slope monitoring case.展开更多
Hepatitis C virus(HCV) is the main cause of chronic liver disease and cirrhosis in Western countries. Over time, the majority of cirrhotic patients develop hepatocellular carcinoma(HCC), one of the most common fatal c...Hepatitis C virus(HCV) is the main cause of chronic liver disease and cirrhosis in Western countries. Over time, the majority of cirrhotic patients develop hepatocellular carcinoma(HCC), one of the most common fatal cancers worldwide- fourth for incidence rate. A high public health priority need is the development of biomarkers to screen for liver disease progression and for early diagnosis of HCC development, particularly in the high risk population represented by HCV-positive patients with cirrhosis. Several studies have shown that serological determination of a novel biomarker, squamous cell carcinoma antigen-immunoglobulins M(SCCA-Ig M), might be useful to identify patients with progressive liver disease. In the initial part of this review we summarize the main clinical studies that have investigated this new circulating biomarker on HCV-infected patients, providing evidence that in chronic hepatitis C SCCA-Ig M may be used to monitor progression of liver disease, and also to assess the virological response to antiviral treatment. In the last part of this review we address other, not less important, clinical applications of this biomarker in hepatology.展开更多
In this work,we report observations of three comets:38P/Stephan-Oterma,64P/Swift-Gehrels,and C/2017 M4(ATLAS),conducted with the Nanshan one-meter wide-field telescope in 2018 August and November,and 2019January.We ex...In this work,we report observations of three comets:38P/Stephan-Oterma,64P/Swift-Gehrels,and C/2017 M4(ATLAS),conducted with the Nanshan one-meter wide-field telescope in 2018 August and November,and 2019January.We extracted morphological features through image enhancement techniques and calculated the dust activity parameter,Afρ,along with dust mass loss rates and coma color indices using broadband photometric data.Our morphological analysis uncovered a spectrum of dust characteristics among the observed comets,ranging from a significant twisted structure in comet 38P/Stephan-Oterma’s coma to the regular coma envelope surrounding comet 64P/Swift-Gehrels.The Afρvalues varied between 148.8±0.3 cm for 64P/Swift-Gehrels and1118.5±6.2 cm for C/2017 M4(ATLAS)(measured within a reference aperture radius ofρ=6″),indicating a range from moderate to high activity levels.Dust mass loss rates were estimated from 328.1 kg s^(-1)for comet 64P/Swift-Gehrels to 1395.5 kg s^(-1)for comet C/2017 M4(ATLAS).The color indices of comets 38P/Stephan-Oterma and C/2017 M4(ATLAS)closely resemble the average colors of active short-period comets and active longperiod comets,respectively.In contrast,64P/Swift-Gehrels exhibits a significantly bluer hue than typical Jupiter family comets.展开更多
文摘The Eastern Sikkim area forming a part of the Lesser Himalaya is located between 27°10′～27°30′N latitudes and 88°25′～88°40′E longitudes (750km 2). The previous workers agreed that a domal structure is present in Sikkim which is constituted by low to high grade metamorphic rocks characterised by inverted metamorphism. The rocks were repeatedly deformed and were metamorphosed at about 550 to 770℃ (550 to 750MPa). Geologically, the oldest rocks of Eastern Sikkim are represented by Darjeeling Formation showing medium to high grade metamorphism. It is followed by low grade Daling Formation which is characterised by tectonic wedges of Lingtse gneiss. The potassic syenite intrusive i.e. the Sikkim igneous formation is youngest rock type of the area. The Darjeeling Formation associated with amphibolite bands consists of kyanite\|sillimanite, staurolite and garnet zones, while the Daling Formation is characterised by low grade chloritoid and chlorite zones. Lingtse Formation is gneissic in which patches of retrograded and sheared garnet schists are present. Intrusions of potassic syenites (Sikkim Formation) occur in the form of oval and concordant bodies. The F 1, F 2 and F 3 folds are well developed in rocks of Eastern Sikkim area.. The F 1 folds are rootless, tightly isoclinal or reclined and highly obliterated in their attitude. The F 2 folds belong to class IC of Ramsay (1967). Their interlimb angles vary from 20～50 degrees. Intersection lineation due to S 0/S 1 and S 2 surfaces is parallel to the F 2 folds axis. Third generation structures are represented by open to moderately tight and kinked folds. Superimposition of F 3 folds on F 2 folds resulted into type II interference pattern of Ramsay (1967). Structural analysis of these folds have revealed that F 2 folds are non\|cylindrical. The kink or F 3 folds were possibly responsible for the formation of a megakink resembling with the domal structure. The repeatedly deformed rocks of Eastern Sikkim area were folded, faulted, sheared/thrusted during the Himalayan orogeny. The Main Central Thrust (M C T) is actually a ductile shear zone and was subjected to imbrication during later phases of F 2 folding.
基金financially supported by Chinese Academy of Nutritional Sciences,Shanghai Institutes for Biological Sciences
文摘One new Iriterpene saponin was isolated from Panaxjaponicus C. A. Meyer var major （Burk.） C. Y. Wu et K. M. Feng, and established as oleanolic acid 3-O-[β-D-glucopyranosyl-（1 →2）-β-D-glucuronopyranosyl-6＇-O-n-butyl ester] which showed mod- erate antitumor activities against the A2780 cells and OVCAR-3 cells. Its structure was established by means of spectral data, particularly NMR, including HSQC and HMBC techniques.
文摘Due to France has suffered from many terrorist attacks and the number of visitors to the Louvre has gradually increased in recent years, a good evacuation plan for the Louvre is of vital significance. We use the minimization of the total evacuation time of all tourists as the optimization goal to find an optimal path. For conventional emergencies, a static model is built to evacuate visitors. And then we establish a nonlinear programming model. Using Lingo software, we get the distribution information of the visitors in different exhibition halls. For unconventional emergencies, we establish an adaptive dynamic model of tourist evacuation based on genetic algorithm. The sensitivity analysis of the model is considered by adding new paths. By solving the nonlinear programming problem with the double objective function of maximizing evacuation time and balancing the number of people in every path, we get the evacuation time last 1582.74 s. Finally, according to our result, we built mathematical models for the evacuation after an emergency and analyzed how to adapt and implement our models for other large and crowded structures.
基金TheNationalNaturalScienceFoundationofChina! (No .497742 0 9)
文摘Originated in the early 1990s, SCGM(1, m ) c model has enjoyed widespread application in the fields of urban planning, society economy prediction and modal control in recent years. However, none of these applications have taken account of time lag effects in the modeling process. Aiming at overcoming the defect, the authors introduced time lag items into SCGM(1, m ) c model and developed a SCGM(1, m ) c model with time lag, then discusses in detail some principal problems in the model, such as parameters estimation, model verifying, model prediction, etc. The model was used on a real slope monitoring project and compared with the conventional SCGM(1, m ) c model. The results show an improvement of average models precision from 1.321 to 0.238 and total average of relative prediction errors from 12.41% to 7.98% when the modeling data length ranges from 29 to 48 in the slope monitoring case.
文摘Hepatitis C virus(HCV) is the main cause of chronic liver disease and cirrhosis in Western countries. Over time, the majority of cirrhotic patients develop hepatocellular carcinoma(HCC), one of the most common fatal cancers worldwide- fourth for incidence rate. A high public health priority need is the development of biomarkers to screen for liver disease progression and for early diagnosis of HCC development, particularly in the high risk population represented by HCV-positive patients with cirrhosis. Several studies have shown that serological determination of a novel biomarker, squamous cell carcinoma antigen-immunoglobulins M(SCCA-Ig M), might be useful to identify patients with progressive liver disease. In the initial part of this review we summarize the main clinical studies that have investigated this new circulating biomarker on HCV-infected patients, providing evidence that in chronic hepatitis C SCCA-Ig M may be used to monitor progression of liver disease, and also to assess the virological response to antiviral treatment. In the last part of this review we address other, not less important, clinical applications of this biomarker in hepatology.
基金supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region of China(grant No.2021D01B112)Tianshan Talent Training Program through the grant 2023TSYCCX0101。
文摘In this work,we report observations of three comets:38P/Stephan-Oterma,64P/Swift-Gehrels,and C/2017 M4(ATLAS),conducted with the Nanshan one-meter wide-field telescope in 2018 August and November,and 2019January.We extracted morphological features through image enhancement techniques and calculated the dust activity parameter,Afρ,along with dust mass loss rates and coma color indices using broadband photometric data.Our morphological analysis uncovered a spectrum of dust characteristics among the observed comets,ranging from a significant twisted structure in comet 38P/Stephan-Oterma’s coma to the regular coma envelope surrounding comet 64P/Swift-Gehrels.The Afρvalues varied between 148.8±0.3 cm for 64P/Swift-Gehrels and1118.5±6.2 cm for C/2017 M4(ATLAS)(measured within a reference aperture radius ofρ=6″),indicating a range from moderate to high activity levels.Dust mass loss rates were estimated from 328.1 kg s^(-1)for comet 64P/Swift-Gehrels to 1395.5 kg s^(-1)for comet C/2017 M4(ATLAS).The color indices of comets 38P/Stephan-Oterma and C/2017 M4(ATLAS)closely resemble the average colors of active short-period comets and active longperiod comets,respectively.In contrast,64P/Swift-Gehrels exhibits a significantly bluer hue than typical Jupiter family comets.
