To assess the effectiveness of vaccination in contaminated environments,this study introduces a modeling framework that encompasses two transmission routes,namely direct human-to-human contact and indirect human-to-en...To assess the effectiveness of vaccination in contaminated environments,this study introduces a modeling framework that encompasses two transmission routes,namely direct human-to-human contact and indirect human-to-environment contact,as well as the implementation of new M72/AS01_(E)vaccine.Motivated by this,a coupled age-structured tuberculosis(TB)model is proposed.Its well-posedness requirement is verified using the integrated semigroup theory.Furthermore,this study presents a comprehensive analysis of threshold dynamics associated with the proposed model.Specifically,the global stability of the disease-free and positive steady states is demonstrated by employing Lyapunov functionals.Lastly,the effects of the vaccination with M72/AS01_(E)and contaminated environments on TB control are numerically simulated.Experimental results indicate that high concentrations of Mycobacterium tuberculosis in contaminated environments may somewhat impede TB control efforts,but that large-scale deployment of new vaccine could significantly reduce the prevalence of TB.展开更多
This study systematically analyzed the spatiotemporal evolution characteristics of geomagnetic anomalies before and after the 2013 Sichuan Lushan M7.0 earthquake and the Gansu Minxian M6.6 earthquake by constructing a...This study systematically analyzed the spatiotemporal evolution characteristics of geomagnetic anomalies before and after the 2013 Sichuan Lushan M7.0 earthquake and the Gansu Minxian M6.6 earthquake by constructing a geomagnetic diurnal variation model based on Taylor polynomial fitting,combined with midnight mean values of the geomagnetic F component from China,s geomagnetic observatory network.The results reveal distinct differences in anomaly patterns,namely per-sistent positive anomalies were observed in the epicentral region of the Lushan earthquake,while significant negative anomalies characterized the Minxian earthquake zone.This differential response reveals the modulating effect of the electrical structure of the seismogenic medium on space electromagnetic disturbances,namely positive anomalies may correspond to the stage of stable stress accumulation in intact rock,while the expansion of negative anomalies may reflect an amplification of electromagnetic disturbances induced by fracture expansion.Further analysis demonstrates that both anomalies exhibit a three-stage evolutionary pattern,namely pre-seismic accumulation,co-seismic release,and post-seismic adjustment.The phase transitions in these anomalies are closely correlated with regional tectonic stress accumulation and destabilization processes.These findings not only provide new evidence for the physical interpretation of seismomagnetic precursors but also establish a theoretical foundation for developing earthquake prediction methods based on the dynamic evolution of geomagnetic anomalies.展开更多
Scour around bridge pier foundations is a complex phenomenon that can threaten structural stability.Accurate prediction of scour depth around compound piers remains challenging for bridge engineers.This study investig...Scour around bridge pier foundations is a complex phenomenon that can threaten structural stability.Accurate prediction of scour depth around compound piers remains challenging for bridge engineers.This study investigated the effect of foundation elevation on scour around compound piers and developed reliable scour depth prediction models for economical foundation design.Experiments were conducted under clear-water conditions using two circular piers:(1)a uniform pier(with a diameter of D)and(2)a compound pier consisting of a uniform pier resting on a circular foundation(with a foundation diameter(D_(f))of 2D)positioned at various elevations(Z)relative to the channel bed.Results showed that foundation elevation significantly affected scour depth.Foundations at or below the bed(Z/D≥0)reduced scour,while those projecting into the flow field(Z/D<0)increased scour.The optimal foundation elevation was found to be 0.1D below the bed level,yielding a 57%reduction in scour depth compared to the uniform pier due to its shielding effect against downflow and horseshoe vortices.In addition,regression,artificial neural network(ANN),and M5 model tree models were developed using experimental data from this and previous studies.The M5 model outperformed the traditional HEC-18 equation,regression,and ANN models,with a coefficient of determination greater than 0.85.Sensitivity analysis indicated that flow depth,foundation elevation,and diameter significantly influenced scour depth prediction,whereas sediment size had a lesser impact.展开更多
In 2018,a catastrophic high-altitude landslide occurred at Baige,located within the tectonic suture zone of the Upper Jinsha River.The failure mechanism of this event remains poorly understood.This study aims to eluci...In 2018,a catastrophic high-altitude landslide occurred at Baige,located within the tectonic suture zone of the Upper Jinsha River.The failure mechanism of this event remains poorly understood.This study aims to elucidate the deformation characteristics and failure mechanism of the Baige landslide by employing a comprehensive methodology,including field geological surveys,analysis of historical remote sensing imagery,high-density electrical resistivity surveys,and advanced displacement monitoring.Additionally,the physical modeling experiments were conducted to replicate the unique failure modes.The findings propose a novel perspective on the failure mechanism of the Baige landslide,which involves two critical stages:first,the brittle shear zone bypasses and fails at the lower locked segment,and second,the failure of the upper locked segment,combined with the shear zone's impact on the lower locked segment,triggers overall slope instability.Physical modeling experiments revealed a transition from initial acceleration to a rapid acceleration phase,particularly marked by a significant increase in velocity following the failure of the upper locked segment.The intensity of acoustic emission signals was found to correlate with the failure of the locked segments and the state of particle collisions post-failure.It offers new insights into the failure mechanisms of tectonic mélange belt large-scale landslides in suture zones,contributing to the broader field of landslide research.展开更多
In the article titled“Inhibiting SHP2 reduces glycolysis,promotes microglial M1 polarization,and alleviates secondary inflammation following spinal cord injury in a mouse model,”published in Neural Regeneration Rese...In the article titled“Inhibiting SHP2 reduces glycolysis,promotes microglial M1 polarization,and alleviates secondary inflammation following spinal cord injury in a mouse model,”published in Neural Regeneration Research(Ding et al.,2025),the title was incorrectly presented due to an error during the language polishing process.展开更多
The early precipitation process of Ni（75）Al（14）Mo（11） alloy was simulated by microscopic phase-field model at different temperatures.The microstructure of the alloy,the precipitation time of Llo structure and oc...The early precipitation process of Ni（75）Al（14）Mo（11） alloy was simulated by microscopic phase-field model at different temperatures.The microstructure of the alloy,the precipitation time of Llo structure and occupation probability of the three kinds of atoms were investigated.It is indicated that the non-stoichiometric Ll0（Ⅰ/Ⅱ） phases are found in the precipitation process.With the temperature increasing,the appearance time of Ll0 is brought forward.The Ll0（Ⅱ） structure always precipitates earlier than the Ll0（Ⅰ） structure.Compared with lower temperature,higher temperature brings the formation time of Ll0 phase forward and makes Ll0 phase have a higher order degree.But lower temperature shortens the process time of the Ll0 phase to the Ll2 phase.Al and Mo atoms tend to occupy γ site,Ni atom tends to occupy a and β sites.At the same temperature,Al atom has stronger occupation ability than Mo atom in the same site.Ni,Al and Mo collectively form the composited Ll2 structure.展开更多
The construction method of background value is improved in the original multi-variable grey model （MGM（1,m）） from its source of construction errors. The MGM（1,m） with optimized background value is used to elimin...The construction method of background value is improved in the original multi-variable grey model （MGM（1,m）） from its source of construction errors. The MGM（1,m） with optimized background value is used to eliminate the random fluctuations or errors of the observational data of all variables, and the combined prediction model together with the multiple linear regression is established in order to improve the simulation and prediction accuracy of the combined model. Finally, a combined model of the MGM（1,2） with optimized background value and the binary linear regression is constructed by an example. The results show that the model has good effects for simulation and prediction.展开更多
To discover new lead compounds for M1 agonists. Ten typical M1 agonists were superimposed to build a M1 agonists 3D-pharmacophore model using distance-comparisons （DISCO） method without the previous knowledge of the...To discover new lead compounds for M1 agonists. Ten typical M1 agonists were superimposed to build a M1 agonists 3D-pharmacophore model using distance-comparisons （DISCO） method without the previous knowledge of the three-dimensional structure of M1 receptor. Virtual screening strategy was used to analyze the Available Chemicals Directory-Screening Compounds （ACD-SC） to identify possible new hits. Twenty-two compounds which fit the pharmacophore model well and are not similar with known M1 agonists were purchased in order to evaluate their M1 receptor agonist activity. One of them shows M1 receptor agonist activity with EC50 of 4.90 μmol/L and maximum response. Multiple of 10.0 which shows it worthy of further study as a new lead compound for M1 agonists.展开更多
By studying the spectral properties of the underlying operator corresponding to the M/G/1 queueing model with optional second service we obtain that the time-dependent solution of the model strongly converges to its s...By studying the spectral properties of the underlying operator corresponding to the M/G/1 queueing model with optional second service we obtain that the time-dependent solution of the model strongly converges to its steady-state solution. We also show that the time-dependent queueing size at the departure point converges to the corresponding steady-state queueing size at the departure point.展开更多
The unique structure and complex deformation characteristics of concrete face rockfill dams(CFRDs)create safety monitoring challenges.This study developed an improved random forest(IRF)model for dam health monitoring ...The unique structure and complex deformation characteristics of concrete face rockfill dams(CFRDs)create safety monitoring challenges.This study developed an improved random forest(IRF)model for dam health monitoring modeling by replacing the decision tree in the random forest(RF)model with a novel M5'model tree algorithm.The factors affecting dam deformation were preliminarily selected using the statistical model,and the grey relational degree theory was utilized to reduce the dimensions of model input variables.Finally,a deformation prediction model of CFRDs was established using the IRF model.The ten-fold cross-validation method was used to quantitatively analyze the parameters affecting the IRF algorithm.The performance of the established model was verified using data from three specific measurement points on the Jishixia dam and compared with other dam deformation prediction models.At point ES-10,the performance evaluation indices of the IRF model were superior to those of the M5'model tree and RF models and the classical support vector regression(SVR)and back propagation(BP)neural network models,indicating the satisfactory performance of the IRF model.The IRF model also outperformed the SVR and BP models in settlement prediction at points ES2-8 and ES4-10,demonstrating its strong anti-interference and generalization capabilities.This study has developed a novel method for forecasting and analyzing dam settlements with practical significance.Moreover,the established IRF model can also provide guidance for modeling health monitoring of other structures.展开更多
In order to effectively predict the fracture of AA7075-T6 sheet, the forming limit curves of AA7075-T6 high-strength sheet were drawn according to Morciniak Kuczyski (M K) model and Lou Huh criterion, respectively. Th...In order to effectively predict the fracture of AA7075-T6 sheet, the forming limit curves of AA7075-T6 high-strength sheet were drawn according to Morciniak Kuczyski (M K) model and Lou Huh criterion, respectively. The errors between the predicted values of the two theoretical prediction models and experimental values were calculated by error analysis. The forming limit curves were verified by the punch stretch test to evaluate the prediction accuracy of M K model and Lou Huh criterion. The error analysis results show that the mean error of Lou Huh criterion with the optimal parameters for all tensile specimens is 25.04%, while the mean error of M K model for all tensile specimens is 74.24%. The prediction accuracy of Lou Huh criterion in predicting the fracture of AA7075-T6 sheet is higher. The punch stretch test results show that the forming limit curve drawn by Lou Huh criterion can effectively predict the fracture of AA7075-T6 sheet, but the prediction accuracy of M K model is relatively poor.展开更多
文摘To assess the effectiveness of vaccination in contaminated environments,this study introduces a modeling framework that encompasses two transmission routes,namely direct human-to-human contact and indirect human-to-environment contact,as well as the implementation of new M72/AS01_(E)vaccine.Motivated by this,a coupled age-structured tuberculosis(TB)model is proposed.Its well-posedness requirement is verified using the integrated semigroup theory.Furthermore,this study presents a comprehensive analysis of threshold dynamics associated with the proposed model.Specifically,the global stability of the disease-free and positive steady states is demonstrated by employing Lyapunov functionals.Lastly,the effects of the vaccination with M72/AS01_(E)and contaminated environments on TB control are numerically simulated.Experimental results indicate that high concentrations of Mycobacterium tuberculosis in contaminated environments may somewhat impede TB control efforts,but that large-scale deployment of new vaccine could significantly reduce the prevalence of TB.
基金supported by a Collaborative Project of the National Natural Science Foundation of China on Technical Maintenance and Data Preprocessing of the GPS Observation Array for the Qiaojia Earthquake(No.0120603)the National Natural Science Foundation of China(No.41274079).
文摘This study systematically analyzed the spatiotemporal evolution characteristics of geomagnetic anomalies before and after the 2013 Sichuan Lushan M7.0 earthquake and the Gansu Minxian M6.6 earthquake by constructing a geomagnetic diurnal variation model based on Taylor polynomial fitting,combined with midnight mean values of the geomagnetic F component from China,s geomagnetic observatory network.The results reveal distinct differences in anomaly patterns,namely per-sistent positive anomalies were observed in the epicentral region of the Lushan earthquake,while significant negative anomalies characterized the Minxian earthquake zone.This differential response reveals the modulating effect of the electrical structure of the seismogenic medium on space electromagnetic disturbances,namely positive anomalies may correspond to the stage of stable stress accumulation in intact rock,while the expansion of negative anomalies may reflect an amplification of electromagnetic disturbances induced by fracture expansion.Further analysis demonstrates that both anomalies exhibit a three-stage evolutionary pattern,namely pre-seismic accumulation,co-seismic release,and post-seismic adjustment.The phase transitions in these anomalies are closely correlated with regional tectonic stress accumulation and destabilization processes.These findings not only provide new evidence for the physical interpretation of seismomagnetic precursors but also establish a theoretical foundation for developing earthquake prediction methods based on the dynamic evolution of geomagnetic anomalies.
文摘Scour around bridge pier foundations is a complex phenomenon that can threaten structural stability.Accurate prediction of scour depth around compound piers remains challenging for bridge engineers.This study investigated the effect of foundation elevation on scour around compound piers and developed reliable scour depth prediction models for economical foundation design.Experiments were conducted under clear-water conditions using two circular piers:(1)a uniform pier(with a diameter of D)and(2)a compound pier consisting of a uniform pier resting on a circular foundation(with a foundation diameter(D_(f))of 2D)positioned at various elevations(Z)relative to the channel bed.Results showed that foundation elevation significantly affected scour depth.Foundations at or below the bed(Z/D≥0)reduced scour,while those projecting into the flow field(Z/D<0)increased scour.The optimal foundation elevation was found to be 0.1D below the bed level,yielding a 57%reduction in scour depth compared to the uniform pier due to its shielding effect against downflow and horseshoe vortices.In addition,regression,artificial neural network(ANN),and M5 model tree models were developed using experimental data from this and previous studies.The M5 model outperformed the traditional HEC-18 equation,regression,and ANN models,with a coefficient of determination greater than 0.85.Sensitivity analysis indicated that flow depth,foundation elevation,and diameter significantly influenced scour depth prediction,whereas sediment size had a lesser impact.
基金supported by the National Major Scientific Instruments and Equipment Development Projects of China(No.41827808)the Major Program of the National Natural Science Foundation of China(No.42090055)Supported by Science and Technology Projects of Xizang Autonomous Region,China(No.XZ202402ZD0001)。
文摘In 2018,a catastrophic high-altitude landslide occurred at Baige,located within the tectonic suture zone of the Upper Jinsha River.The failure mechanism of this event remains poorly understood.This study aims to elucidate the deformation characteristics and failure mechanism of the Baige landslide by employing a comprehensive methodology,including field geological surveys,analysis of historical remote sensing imagery,high-density electrical resistivity surveys,and advanced displacement monitoring.Additionally,the physical modeling experiments were conducted to replicate the unique failure modes.The findings propose a novel perspective on the failure mechanism of the Baige landslide,which involves two critical stages:first,the brittle shear zone bypasses and fails at the lower locked segment,and second,the failure of the upper locked segment,combined with the shear zone's impact on the lower locked segment,triggers overall slope instability.Physical modeling experiments revealed a transition from initial acceleration to a rapid acceleration phase,particularly marked by a significant increase in velocity following the failure of the upper locked segment.The intensity of acoustic emission signals was found to correlate with the failure of the locked segments and the state of particle collisions post-failure.It offers new insights into the failure mechanisms of tectonic mélange belt large-scale landslides in suture zones,contributing to the broader field of landslide research.
文摘In the article titled“Inhibiting SHP2 reduces glycolysis,promotes microglial M1 polarization,and alleviates secondary inflammation following spinal cord injury in a mouse model,”published in Neural Regeneration Research(Ding et al.,2025),the title was incorrectly presented due to an error during the language polishing process.
基金Project(51275486)supported by the National Natural Science Foundation of China
文摘The early precipitation process of Ni（75）Al（14）Mo（11） alloy was simulated by microscopic phase-field model at different temperatures.The microstructure of the alloy,the precipitation time of Llo structure and occupation probability of the three kinds of atoms were investigated.It is indicated that the non-stoichiometric Ll0（Ⅰ/Ⅱ） phases are found in the precipitation process.With the temperature increasing,the appearance time of Ll0 is brought forward.The Ll0（Ⅱ） structure always precipitates earlier than the Ll0（Ⅰ） structure.Compared with lower temperature,higher temperature brings the formation time of Ll0 phase forward and makes Ll0 phase have a higher order degree.But lower temperature shortens the process time of the Ll0 phase to the Ll2 phase.Al and Mo atoms tend to occupy γ site,Ni atom tends to occupy a and β sites.At the same temperature,Al atom has stronger occupation ability than Mo atom in the same site.Ni,Al and Mo collectively form the composited Ll2 structure.
基金supported by the National Natural Science Foundation of China(71071077)the Ministry of Education Key Project of National Educational Science Planning(DFA090215)+1 种基金China Postdoctoral Science Foundation(20100481137)Funding of Jiangsu Innovation Program for Graduate Education(CXZZ11-0226)
文摘The construction method of background value is improved in the original multi-variable grey model （MGM（1,m）） from its source of construction errors. The MGM（1,m） with optimized background value is used to eliminate the random fluctuations or errors of the observational data of all variables, and the combined prediction model together with the multiple linear regression is established in order to improve the simulation and prediction accuracy of the combined model. Finally, a combined model of the MGM（1,2） with optimized background value and the binary linear regression is constructed by an example. The results show that the model has good effects for simulation and prediction.
基金National Natural Science Foundation of China (Grant No. 30271538)985 program,Ministry of Education of China
文摘To discover new lead compounds for M1 agonists. Ten typical M1 agonists were superimposed to build a M1 agonists 3D-pharmacophore model using distance-comparisons （DISCO） method without the previous knowledge of the three-dimensional structure of M1 receptor. Virtual screening strategy was used to analyze the Available Chemicals Directory-Screening Compounds （ACD-SC） to identify possible new hits. Twenty-two compounds which fit the pharmacophore model well and are not similar with known M1 agonists were purchased in order to evaluate their M1 receptor agonist activity. One of them shows M1 receptor agonist activity with EC50 of 4.90 μmol/L and maximum response. Multiple of 10.0 which shows it worthy of further study as a new lead compound for M1 agonists.
基金supported by the National Natural Science Foundation of China(11371303)Natural Science Foundation of Xinjiang(2012211A023)Science Foundation of Xinjiang University(XY110101)
文摘By studying the spectral properties of the underlying operator corresponding to the M/G/1 queueing model with optional second service we obtain that the time-dependent solution of the model strongly converges to its steady-state solution. We also show that the time-dependent queueing size at the departure point converges to the corresponding steady-state queueing size at the departure point.
基金supported by the National Natural Science Foundation of China(Grant No.51979224)the China National Funds for Distinguished Young Scientists(Grant No.52125904).
文摘The unique structure and complex deformation characteristics of concrete face rockfill dams(CFRDs)create safety monitoring challenges.This study developed an improved random forest(IRF)model for dam health monitoring modeling by replacing the decision tree in the random forest(RF)model with a novel M5'model tree algorithm.The factors affecting dam deformation were preliminarily selected using the statistical model,and the grey relational degree theory was utilized to reduce the dimensions of model input variables.Finally,a deformation prediction model of CFRDs was established using the IRF model.The ten-fold cross-validation method was used to quantitatively analyze the parameters affecting the IRF algorithm.The performance of the established model was verified using data from three specific measurement points on the Jishixia dam and compared with other dam deformation prediction models.At point ES-10,the performance evaluation indices of the IRF model were superior to those of the M5'model tree and RF models and the classical support vector regression(SVR)and back propagation(BP)neural network models,indicating the satisfactory performance of the IRF model.The IRF model also outperformed the SVR and BP models in settlement prediction at points ES2-8 and ES4-10,demonstrating its strong anti-interference and generalization capabilities.This study has developed a novel method for forecasting and analyzing dam settlements with practical significance.Moreover,the established IRF model can also provide guidance for modeling health monitoring of other structures.
基金Project (51775481) supported by the National Natural Science Foundation of ChinaProject (E2019203418) supported by the Natural Science Foundation of Hebei Province, ChinaProject (ZD2017078) supported by the Science and Technology Plan of Hebei Higher School of Education Department, China。
文摘In order to effectively predict the fracture of AA7075-T6 sheet, the forming limit curves of AA7075-T6 high-strength sheet were drawn according to Morciniak Kuczyski (M K) model and Lou Huh criterion, respectively. The errors between the predicted values of the two theoretical prediction models and experimental values were calculated by error analysis. The forming limit curves were verified by the punch stretch test to evaluate the prediction accuracy of M K model and Lou Huh criterion. The error analysis results show that the mean error of Lou Huh criterion with the optimal parameters for all tensile specimens is 25.04%, while the mean error of M K model for all tensile specimens is 74.24%. The prediction accuracy of Lou Huh criterion in predicting the fracture of AA7075-T6 sheet is higher. The punch stretch test results show that the forming limit curve drawn by Lou Huh criterion can effectively predict the fracture of AA7075-T6 sheet, but the prediction accuracy of M K model is relatively poor.
