Objectives:Benign prostatic hyperplasia(BPH)is a common benign tumor in men,with an age-related prevalence of multifactorial etiology.The present study aimed to accurately assess and predict the effect of co-existing ...Objectives:Benign prostatic hyperplasia(BPH)is a common benign tumor in men,with an age-related prevalence of multifactorial etiology.The present study aimed to accurately assess and predict the effect of co-existing metabolic syndrome(MtS)upon treatment outcomes of combination medical therapy in select patients of lower urinary tract symptoms(LUTS)due to BPH.Methods:After obtaining informed consent from the patients,70 eligible patients with LUTS due to BPH with and without MtS were enrolled in this study from September 2022 to January 2024 from the outpatient clinic at the University College of Medical Sciences and Guru Teg Bahadur Hospital,Delhi and were treated with a combination of Tamsulosin and Dutasteride,for two months,as per the protocol.The outcomes measured were a change in the International Prostate Symptom Score(IPSS),mean flow rate(MFR),and peak urine flow(Qmax)rates.Data was analysed using SPSS version 23.Results:The reduction in IPSS was higher in the control group than in the case group(p<0.001),and the difference in MFR between the groups was also statistically significant(p<0.001).Although there was a significant change in Qmax in both groups,the difference in the improvement in Qmax between the two groups was not significant(p<0.829).The control group appeared to have achieved better symptomatic relief after treatment than did the case group.Conclusion:Metabolic syndrome had a negative adverse impact on medical treatment outcomes in selected patients of LUTS due to BPH.The study suggests that urologists should actively consider and appropriately counsel patients with LUTS-BPH and co-existing metabolic syndrome before selecting such patients for combination medical therapy.展开更多
As the two most principal active substances in the corn silk,polysaccharides and flavonoids,the mechanism of interaction between them has been a topic of intense research.This study provides an in-depth investigation ...As the two most principal active substances in the corn silk,polysaccharides and flavonoids,the mechanism of interaction between them has been a topic of intense research.This study provides an in-depth investigation of the interaction mechanism between corn silk glycans and luteoloside(LUT)and the synergistic role that result from this interaction.The interaction mechanism was evaluated by isothermal titration calorimetry(ITC)and circular dichroism(CD),and the synergistic role was evaluated by the expression of glucose transporters(GLUT-1),insulin secretion and surface plasmon resonance(SPR).CD and ITC results indicated that the interaction between CSGs and LUT mainly driven by the Cotton effects,enthalpy and entropy-driven.This interaction precipitated the formation of complexes(CSGs/LUT complexes)between corn silk glycans(CSGs)with four different molecular weights and luteoloside(LUT).Furthermore,the CSGs and LUT play a synergistic role in glucose regulation through GLUT-1 expression and insulin secretion experiments,compared to single luteoloside group.展开更多
A new hybrid FPGA architecture is proposed. The logic tile,which consists of a logic cluster and related connection boxes （CBs）, can be configured as either programmable logic arrays （PLAs） or look-up tables （LUT...A new hybrid FPGA architecture is proposed. The logic tile,which consists of a logic cluster and related connection boxes （CBs）, can be configured as either programmable logic arrays （PLAs） or look-up tables （LUTs）, This architecture can be classified as an AND-LUT array. PLAs are suitable for the implementation of high fan-in logic circuits, while LUTs are used to implement low fan-in logic circuits. As a result, the proposed hybrid FPGA architecture （HFA） is more flexible to improve logic density. Experiments based on MCNC benchmark circuits were performed in both the hybrid architecture and conventional LUT-based symmetrical FPGA architecture in term of area consumption. Preliminary results indicate that on average, the area is reduced by 46% using the new hybrid architecture.展开更多
Based on architecture analysis of island-style F PGA,area and delay models of LUT FPGA are proposed.The models are used to analyze the effect of LUT size on FPGA area and performance.Results show optimal LUT size obta...Based on architecture analysis of island-style F PGA,area and delay models of LUT FPGA are proposed.The models are used to analyze the effect of LUT size on FPGA area and performance.Results show optimal LUT size obtained by computation models is the same as that from experiments:a LUT size of 4 produces the best area results,and a LUT size of 5 provides the better performance.展开更多
文摘Objectives:Benign prostatic hyperplasia(BPH)is a common benign tumor in men,with an age-related prevalence of multifactorial etiology.The present study aimed to accurately assess and predict the effect of co-existing metabolic syndrome(MtS)upon treatment outcomes of combination medical therapy in select patients of lower urinary tract symptoms(LUTS)due to BPH.Methods:After obtaining informed consent from the patients,70 eligible patients with LUTS due to BPH with and without MtS were enrolled in this study from September 2022 to January 2024 from the outpatient clinic at the University College of Medical Sciences and Guru Teg Bahadur Hospital,Delhi and were treated with a combination of Tamsulosin and Dutasteride,for two months,as per the protocol.The outcomes measured were a change in the International Prostate Symptom Score(IPSS),mean flow rate(MFR),and peak urine flow(Qmax)rates.Data was analysed using SPSS version 23.Results:The reduction in IPSS was higher in the control group than in the case group(p<0.001),and the difference in MFR between the groups was also statistically significant(p<0.001).Although there was a significant change in Qmax in both groups,the difference in the improvement in Qmax between the two groups was not significant(p<0.829).The control group appeared to have achieved better symptomatic relief after treatment than did the case group.Conclusion:Metabolic syndrome had a negative adverse impact on medical treatment outcomes in selected patients of LUTS due to BPH.The study suggests that urologists should actively consider and appropriately counsel patients with LUTS-BPH and co-existing metabolic syndrome before selecting such patients for combination medical therapy.
基金The Chinese Academy of Sciences:KFJ-BRP-007-019,the authors declare no competing interests.
文摘As the two most principal active substances in the corn silk,polysaccharides and flavonoids,the mechanism of interaction between them has been a topic of intense research.This study provides an in-depth investigation of the interaction mechanism between corn silk glycans and luteoloside(LUT)and the synergistic role that result from this interaction.The interaction mechanism was evaluated by isothermal titration calorimetry(ITC)and circular dichroism(CD),and the synergistic role was evaluated by the expression of glucose transporters(GLUT-1),insulin secretion and surface plasmon resonance(SPR).CD and ITC results indicated that the interaction between CSGs and LUT mainly driven by the Cotton effects,enthalpy and entropy-driven.This interaction precipitated the formation of complexes(CSGs/LUT complexes)between corn silk glycans(CSGs)with four different molecular weights and luteoloside(LUT).Furthermore,the CSGs and LUT play a synergistic role in glucose regulation through GLUT-1 expression and insulin secretion experiments,compared to single luteoloside group.
文摘A new hybrid FPGA architecture is proposed. The logic tile,which consists of a logic cluster and related connection boxes （CBs）, can be configured as either programmable logic arrays （PLAs） or look-up tables （LUTs）, This architecture can be classified as an AND-LUT array. PLAs are suitable for the implementation of high fan-in logic circuits, while LUTs are used to implement low fan-in logic circuits. As a result, the proposed hybrid FPGA architecture （HFA） is more flexible to improve logic density. Experiments based on MCNC benchmark circuits were performed in both the hybrid architecture and conventional LUT-based symmetrical FPGA architecture in term of area consumption. Preliminary results indicate that on average, the area is reduced by 46% using the new hybrid architecture.
文摘Based on architecture analysis of island-style F PGA,area and delay models of LUT FPGA are proposed.The models are used to analyze the effect of LUT size on FPGA area and performance.Results show optimal LUT size obtained by computation models is the same as that from experiments:a LUT size of 4 produces the best area results,and a LUT size of 5 provides the better performance.
