Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-k...Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-kappa B(NF-κB)pathway contributes to inflammation-induced peripheral nerve damage,affecting cell survival.Juan Bi Tong Luo(JBTL),a traditional Chinese medicine(TCM),has demonstrated favorable results in alleviating pain and numbness in patients with DPN;however,whether JBTL exerts its effect through the MAPK mediating NF-κB pathway remains unclear.Methods:This study investigated whether JBTL modulates apoptosis in DPN models and Schwann cells cultured in 100 mM of glucose by MAPK/NF-κB.Results:The JBTL altered inflammation,reduced peripheral nerve tissue damage,and improved cell survival rates by down-regulating MAPK/NF-κB.Conclusion:Our findings demonstrate that the effect of JBTL on DPN is likely mediated by suppressing inflammation induced by the MAPK/NF-κB pathway,thus providing evidence for the clinical efficacy of JBTL in treating DPN.展开更多
昆明地区下寒武统沧浪铺组乌龙箐段所产的节肢动物Guangweicaris Luo,Fu et Hu,2007,为研究寒武纪生命大爆发之后节肢动物辐射特征提供了重要资料。罗惠麟等(2007)在报道该节肢动物时,因标本不完整,对其头部和尾部特征均作了错误鉴别和...昆明地区下寒武统沧浪铺组乌龙箐段所产的节肢动物Guangweicaris Luo,Fu et Hu,2007,为研究寒武纪生命大爆发之后节肢动物辐射特征提供了重要资料。罗惠麟等(2007)在报道该节肢动物时,因标本不完整,对其头部和尾部特征均作了错误鉴别和描述。笔者根据完整且保存有软体附肢的标本,对Guangweicaris Luo,Fu et Hu,2007作了重新研究和复原,据此讨论了该节肢动物的分类归属问题。展开更多
As a thinking pattern,"Luo Shu" has been widely used in the classical Chinese garden art with its core lying in the application of nine-palace square.This paper analyzed the wide application of "Luo Shu...As a thinking pattern,"Luo Shu" has been widely used in the classical Chinese garden art with its core lying in the application of nine-palace square.This paper analyzed the wide application of "Luo Shu" wisdom in classical Chinese garden art,which can be summarized into 3 respects including the creation technique of yin and yang(masculine and feminine elements) contrast,the overall-balanced gardening concept and the aesthetic pursuit in curve design.Through analyzing the application of numbers in the "Luo Shu" pattern,the application of contrast,balance and harmony in classical Chinese garden were revealed.展开更多
Objective To investigate the ability of Tong Luo Jiu Nao(TLJN)Oral Solution to improve cognitive and gait deficits in a rat model of focal cerebral ischemia.Methods An intraluminal suture method was used to create a r...Objective To investigate the ability of Tong Luo Jiu Nao(TLJN)Oral Solution to improve cognitive and gait deficits in a rat model of focal cerebral ischemia.Methods An intraluminal suture method was used to create a rat model of focal cerebral ischemia.Experimental animals were divided into4groups:sham surgery,cerebral ischemia model,cerebral ischemia model+low-dose TLJN Oral Solution(150mg/kg),cerebral ischemia model+high-dose TLJN Oral Solution(300mg/kg).After4weeks of drug intervention,water maze and gait analyses were conducted.Brain tissue was stained with hematoxylin and eosin and used to monitor and calculate the volume ratio of cerebral infarction in each group of permanent middle cerebral artery occlusion(pMCAO)rats.Results(1)Gait analyses:TLJN Oral Solution significantly improved the overall gait of the focal cerebral ischemic rat model.The improvement in walking speed might have been achieved by the shortening of the animals’stride time.The shortening of stance time by TLJN in the cerebral ischemic animals might be due to the shortening of brake and propulsion times,while the shortening of stride time by TLJN in the cerebral ischemic animals might have been due to the shortening of stance time and swing time.(2)Water maze navigation test:high-dose TLJN Oral Solution significantly reduced the animals’total swimming distance and duration and increased the proportion of swimming distance and time spent in the target quadrant,suggesting that TLJN significantly improved the cognitive deficit in the animal model.(3)High-dose TLJN significantly reduced the cerebral infarction volume ratio of the pMCAO rats.Conclusion This intraluminal suture method can reliably replicate a rat model of focal cerebral ischemia.TLJN Oral Solution improves the gait and cognitive function of the focal cerebral ischemia rat model to various extents.展开更多
With the national second child policy, old-age fertility problem increasingly prominent, female fertility decline by the increase of age, so the incidence of infertility also will increase from the understanding of di...With the national second child policy, old-age fertility problem increasingly prominent, female fertility decline by the increase of age, so the incidence of infertility also will increase from the understanding of disease dialectical trichotomy therapy to summarize professor LUO Zhi-juan clinical experience infertility think the disease occurs mainly in kidney empty as this, liver and spleen viscera dysfunction to heart, wet phlegm and blood stasis as the main pathological product of common cause kidney - menstruation - ran ren - cell palace reproductive axis dysfunction and infertility.展开更多
Bai Luo Shan(白罗衫)is called“Hamlet”in Chinese opera.Bai Luo Shan was originally a legend written by anonymous people in the Ming Dynasty.It is based on the novel Warning the World·Su Zhi Xian Luo Shan Zai He...Bai Luo Shan(白罗衫)is called“Hamlet”in Chinese opera.Bai Luo Shan was originally a legend written by anonymous people in the Ming Dynasty.It is based on the novel Warning the World·Su Zhi Xian Luo Shan Zai He(警世通言·苏知县罗衫再合),Which tells the story of Sun Yun,which occupies a place in the history of opera and performance.Since the Tang Dynasty,the story of Bai Luo Shan has been widely known among the people,and it has been adpated into a script by a variety of operas.Among them,the Kunqu Opera version of Bai Luo Shan dealing with the protagonist’s dilemma in the face of jurispudence and human relationship shows the contradiction of human nature,strengthens the tragic meaning of the theme,and embodies the unique aesthetic value.展开更多
The 12 animal calendars of the Chinese zodiac are the essence and source of Chinese civilization,and have been deeply rooted in the production,life,and social activities of various ethnic groups in China since ancient...The 12 animal calendars of the Chinese zodiac are the essence and source of Chinese civilization,and have been deeply rooted in the production,life,and social activities of various ethnic groups in China since ancient times.The ancient Luo Yue stone inscription1 is a popular ancient script from four to six thousand years ago,and 17,496 characters have been found,which is the earliest script found on the Chinese land so far.A comparative study of Chinese zodiac characters2 between the ancient Luo Yue stone inscriptions and the oracle bone through paleographic conformation reveals that the two characters have the same and similar characteristics.Therefore,this paper intends to further investigate the kinship between the two,and to conduct a preliminary exploration of the origin,development,and evolution of the zodiac by combining recent human archaeological data,emerging molecular anthropological data,historical literature,and data from the Chinese Civilization Exploration Project,in an attempt to show the integration and dependence of Chinese civilization,the pluralistic pattern of Chinese culture,and the Chinese nation for thousands of years.展开更多
EDITOR’S NOTE:Music With a Tibetan theme enjoys great popularity throughout China and the world at large With its robust yet undulating melody Representative works include Return to Lhasa, Qomolangmo and Qinghai-Tibe...EDITOR’S NOTE:Music With a Tibetan theme enjoys great popularity throughout China and the world at large With its robust yet undulating melody Representative works include Return to Lhasa, Qomolangmo and Qinghai-Tibet Plateau. As they were created With the efforts of both the Han and Tibetan people, such music is hailed as the "Harmonious Han-Tibetan展开更多
With the rise of China as an oriental giant in the world,Chinese culture is increasingly valued by Westerners.As one of the top four masterpieces,Romance of the Three Kingdoms is more and more familiar to foreigners.T...With the rise of China as an oriental giant in the world,Chinese culture is increasingly valued by Westerners.As one of the top four masterpieces,Romance of the Three Kingdoms is more and more familiar to foreigners.This paper introduces the his⁃torical background and historical events depicted in the works of LUO Guanzhong,and lists several themes discussed in The Three Kingdoms.LUO Guanzhong holds profound views on human nature and“tao”of heaven.展开更多
It has been more than a decade since I met Teacher Luo Haocai. Before I met him, I had already heard that he was an approachable scholar. Although he was at a high position and played a leading role in establishing Ch...It has been more than a decade since I met Teacher Luo Haocai. Before I met him, I had already heard that he was an approachable scholar. Although he was at a high position and played a leading role in establishing China’s administrative law, he always had a peaceful mind, which was highly respected and honored by colleagues in the academic community. After I actually met him, I was deeply impressed by the展开更多
President Luo Haocai of the China Society for Human Rights Studies （CSHRS）, who is also former vice chair-man of the Chinese People＇s Political Consultative Conference （CPPCC） National Committee, led a CSHRS del-...President Luo Haocai of the China Society for Human Rights Studies （CSHRS）, who is also former vice chair-man of the Chinese People＇s Political Consultative Conference （CPPCC） National Committee, led a CSHRS del- egation to visit Heilongjiang, Jilin and Liaoning provinces from Sept. 10 to 16, 2012, in order to know more about human rights research and practice as well as promote related training and education in northeast China. Li Buyun, honorary member of the Chinese Academy of Social Sciences （CASS）,展开更多
The Fourth Plenary Session of the 18th Central Committee of the Communist Party of China （CPC） reviewed and approved the Decision of the CPC Central Committee on Certain Key Issues Concerning Comprehensively Pushing...The Fourth Plenary Session of the 18th Central Committee of the Communist Party of China （CPC） reviewed and approved the Decision of the CPC Central Committee on Certain Key Issues Concerning Comprehensively Pushing Forward the Rule of Law （hereafter, ＂Decision＂）. The plenary session was convened at a pivotal stage in comprehensively building a well-off society and comprehen- sively deepening reform. It was the first of its kind with the theme of the rule of law and was a landmark event in China＇s legal construction. The Journal interviewed Professor Luo Haocai, who is also president of the China Society for Human Rights Studies （CSHRS）.展开更多
Chairman Luo Haocai served as the president of CSHRS from 2007 to 2016.During those nine years, he built deep friendships with researchers on human rights.Because President Luo served as vice chairman of the National ...Chairman Luo Haocai served as the president of CSHRS from 2007 to 2016.During those nine years, he built deep friendships with researchers on human rights.Because President Luo served as vice chairman of the National Committee of CPPCC for a long time, we were used to calling him "Chairman Luo." Chairman Luo was a leader with strategic and overall awareness, a scholar-official, an elder with a young mentality, and a motivator and protector of young people.展开更多
Luo Haocai, Vice-Chairman of the National Committee of the Chinese People＇s Political Consultative Conference （CPPCC） and President of China Society for Human Rights Studies （CSHRS）, met with Professor Hans Pette...Luo Haocai, Vice-Chairman of the National Committee of the Chinese People＇s Political Consultative Conference （CPPCC） and President of China Society for Human Rights Studies （CSHRS）, met with Professor Hans Petter Graver, Board Chairman of the Norwegian Center for Human Rights （NCHR）, University of Oslo on the afternoon of September 3. CSHRS Vice President and Secretary-general Dong Yunhu was present at the meeting.展开更多
Craniofacial microsomia(CFM)is a congenital malformation with maxillary and/or mandibular hypoplasia,skin tags,and ear malformations(Luo et al.,2023).Microtia,in its mildest form,can occur alone(Quiat et al.,2023).Wit...Craniofacial microsomia(CFM)is a congenital malformation with maxillary and/or mandibular hypoplasia,skin tags,and ear malformations(Luo et al.,2023).Microtia,in its mildest form,can occur alone(Quiat et al.,2023).With a prevalence of 3.8/100,000(Barisic et al.,2014),CFM is the second most common congenital craniofacial abnormality(Li et al.,2022;Luo et al.,2023).Most cases are sporadic,but familial ones suggest autosomal dominant(AD)or autosomal recessive(AR)(Beleza-Meireles et al.,2014).In 2023,Quiat et al.and Mao et al.successively identified FOXI3 variants in 16 pedigrees and 10 sporadic cases,respectively,accounting for 3.1%of CFM cases(Mao et al.,2023;Quiat et al.,2023).FOX/3 has surpassed SF3B2 as the most frequently identified pathogenic gene for CFM to date(Timberlake et al.,2021;Mao et al.,2023;Quiat et al.,2023).In this study,we performed whole-exome sequencing(WES)on 201 CFM pedigrees and detected FOX/3 variants in 8 AD-inherited pedigrees with 24 patients and 28 unaffected individuals(Fig.1A).展开更多
基金funded by grants from the Suzhou Gusu Health Talents Project(grant No.GSWS2024050 to Liu W)Natural Science Foundation Project of Nanjing University of Chinese Medicine(grant No.XZR2021043 to Liu W and grant No.XZR2023021 to Huang F)+1 种基金Suzhou Science Education Health Youth Project(grant No.KJXW2021046 to Liu W)Suzhou Major Disease Multi-center Clinical Research Project(grant No.DZXYJ202410 to Huang F).
文摘Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-kappa B(NF-κB)pathway contributes to inflammation-induced peripheral nerve damage,affecting cell survival.Juan Bi Tong Luo(JBTL),a traditional Chinese medicine(TCM),has demonstrated favorable results in alleviating pain and numbness in patients with DPN;however,whether JBTL exerts its effect through the MAPK mediating NF-κB pathway remains unclear.Methods:This study investigated whether JBTL modulates apoptosis in DPN models and Schwann cells cultured in 100 mM of glucose by MAPK/NF-κB.Results:The JBTL altered inflammation,reduced peripheral nerve tissue damage,and improved cell survival rates by down-regulating MAPK/NF-κB.Conclusion:Our findings demonstrate that the effect of JBTL on DPN is likely mediated by suppressing inflammation induced by the MAPK/NF-κB pathway,thus providing evidence for the clinical efficacy of JBTL in treating DPN.
文摘昆明地区下寒武统沧浪铺组乌龙箐段所产的节肢动物Guangweicaris Luo,Fu et Hu,2007,为研究寒武纪生命大爆发之后节肢动物辐射特征提供了重要资料。罗惠麟等(2007)在报道该节肢动物时,因标本不完整,对其头部和尾部特征均作了错误鉴别和描述。笔者根据完整且保存有软体附肢的标本,对Guangweicaris Luo,Fu et Hu,2007作了重新研究和复原,据此讨论了该节肢动物的分类归属问题。
文摘As a thinking pattern,"Luo Shu" has been widely used in the classical Chinese garden art with its core lying in the application of nine-palace square.This paper analyzed the wide application of "Luo Shu" wisdom in classical Chinese garden art,which can be summarized into 3 respects including the creation technique of yin and yang(masculine and feminine elements) contrast,the overall-balanced gardening concept and the aesthetic pursuit in curve design.Through analyzing the application of numbers in the "Luo Shu" pattern,the application of contrast,balance and harmony in classical Chinese garden were revealed.
基金funding support from the National Major New Drug Development Program (2015ZX09501004-003-002)A project of the International S&T Cooperation Program of China, 2011DFA32730
文摘Objective To investigate the ability of Tong Luo Jiu Nao(TLJN)Oral Solution to improve cognitive and gait deficits in a rat model of focal cerebral ischemia.Methods An intraluminal suture method was used to create a rat model of focal cerebral ischemia.Experimental animals were divided into4groups:sham surgery,cerebral ischemia model,cerebral ischemia model+low-dose TLJN Oral Solution(150mg/kg),cerebral ischemia model+high-dose TLJN Oral Solution(300mg/kg).After4weeks of drug intervention,water maze and gait analyses were conducted.Brain tissue was stained with hematoxylin and eosin and used to monitor and calculate the volume ratio of cerebral infarction in each group of permanent middle cerebral artery occlusion(pMCAO)rats.Results(1)Gait analyses:TLJN Oral Solution significantly improved the overall gait of the focal cerebral ischemic rat model.The improvement in walking speed might have been achieved by the shortening of the animals’stride time.The shortening of stance time by TLJN in the cerebral ischemic animals might be due to the shortening of brake and propulsion times,while the shortening of stride time by TLJN in the cerebral ischemic animals might have been due to the shortening of stance time and swing time.(2)Water maze navigation test:high-dose TLJN Oral Solution significantly reduced the animals’total swimming distance and duration and increased the proportion of swimming distance and time spent in the target quadrant,suggesting that TLJN significantly improved the cognitive deficit in the animal model.(3)High-dose TLJN significantly reduced the cerebral infarction volume ratio of the pMCAO rats.Conclusion This intraluminal suture method can reliably replicate a rat model of focal cerebral ischemia.TLJN Oral Solution improves the gait and cognitive function of the focal cerebral ischemia rat model to various extents.
基金Youth fund project of guangxi first-class discipline construction and opening subject(No.2019XK175)University-level innovation project for general postgraduate students of guangxi university of traditional Chinese medicine(No.YCSY201900112)
文摘With the national second child policy, old-age fertility problem increasingly prominent, female fertility decline by the increase of age, so the incidence of infertility also will increase from the understanding of disease dialectical trichotomy therapy to summarize professor LUO Zhi-juan clinical experience infertility think the disease occurs mainly in kidney empty as this, liver and spleen viscera dysfunction to heart, wet phlegm and blood stasis as the main pathological product of common cause kidney - menstruation - ran ren - cell palace reproductive axis dysfunction and infertility.
基金this paper is funded by National Social Science Fund major bidding project“Compilation and literature research of the Qing dynasty opera”(11&ZD107).
文摘Bai Luo Shan(白罗衫)is called“Hamlet”in Chinese opera.Bai Luo Shan was originally a legend written by anonymous people in the Ming Dynasty.It is based on the novel Warning the World·Su Zhi Xian Luo Shan Zai He(警世通言·苏知县罗衫再合),Which tells the story of Sun Yun,which occupies a place in the history of opera and performance.Since the Tang Dynasty,the story of Bai Luo Shan has been widely known among the people,and it has been adpated into a script by a variety of operas.Among them,the Kunqu Opera version of Bai Luo Shan dealing with the protagonist’s dilemma in the face of jurispudence and human relationship shows the contradiction of human nature,strengthens the tragic meaning of the theme,and embodies the unique aesthetic value.
文摘The 12 animal calendars of the Chinese zodiac are the essence and source of Chinese civilization,and have been deeply rooted in the production,life,and social activities of various ethnic groups in China since ancient times.The ancient Luo Yue stone inscription1 is a popular ancient script from four to six thousand years ago,and 17,496 characters have been found,which is the earliest script found on the Chinese land so far.A comparative study of Chinese zodiac characters2 between the ancient Luo Yue stone inscriptions and the oracle bone through paleographic conformation reveals that the two characters have the same and similar characteristics.Therefore,this paper intends to further investigate the kinship between the two,and to conduct a preliminary exploration of the origin,development,and evolution of the zodiac by combining recent human archaeological data,emerging molecular anthropological data,historical literature,and data from the Chinese Civilization Exploration Project,in an attempt to show the integration and dependence of Chinese civilization,the pluralistic pattern of Chinese culture,and the Chinese nation for thousands of years.
文摘EDITOR’S NOTE:Music With a Tibetan theme enjoys great popularity throughout China and the world at large With its robust yet undulating melody Representative works include Return to Lhasa, Qomolangmo and Qinghai-Tibet Plateau. As they were created With the efforts of both the Han and Tibetan people, such music is hailed as the "Harmonious Han-Tibetan
文摘With the rise of China as an oriental giant in the world,Chinese culture is increasingly valued by Westerners.As one of the top four masterpieces,Romance of the Three Kingdoms is more and more familiar to foreigners.This paper introduces the his⁃torical background and historical events depicted in the works of LUO Guanzhong,and lists several themes discussed in The Three Kingdoms.LUO Guanzhong holds profound views on human nature and“tao”of heaven.
文摘It has been more than a decade since I met Teacher Luo Haocai. Before I met him, I had already heard that he was an approachable scholar. Although he was at a high position and played a leading role in establishing China’s administrative law, he always had a peaceful mind, which was highly respected and honored by colleagues in the academic community. After I actually met him, I was deeply impressed by the
文摘President Luo Haocai of the China Society for Human Rights Studies （CSHRS）, who is also former vice chair-man of the Chinese People＇s Political Consultative Conference （CPPCC） National Committee, led a CSHRS del- egation to visit Heilongjiang, Jilin and Liaoning provinces from Sept. 10 to 16, 2012, in order to know more about human rights research and practice as well as promote related training and education in northeast China. Li Buyun, honorary member of the Chinese Academy of Social Sciences （CASS）,
文摘The Fourth Plenary Session of the 18th Central Committee of the Communist Party of China （CPC） reviewed and approved the Decision of the CPC Central Committee on Certain Key Issues Concerning Comprehensively Pushing Forward the Rule of Law （hereafter, ＂Decision＂）. The plenary session was convened at a pivotal stage in comprehensively building a well-off society and comprehen- sively deepening reform. It was the first of its kind with the theme of the rule of law and was a landmark event in China＇s legal construction. The Journal interviewed Professor Luo Haocai, who is also president of the China Society for Human Rights Studies （CSHRS）.
文摘Chairman Luo Haocai served as the president of CSHRS from 2007 to 2016.During those nine years, he built deep friendships with researchers on human rights.Because President Luo served as vice chairman of the National Committee of CPPCC for a long time, we were used to calling him "Chairman Luo." Chairman Luo was a leader with strategic and overall awareness, a scholar-official, an elder with a young mentality, and a motivator and protector of young people.
文摘Luo Haocai, Vice-Chairman of the National Committee of the Chinese People＇s Political Consultative Conference （CPPCC） and President of China Society for Human Rights Studies （CSHRS）, met with Professor Hans Petter Graver, Board Chairman of the Norwegian Center for Human Rights （NCHR）, University of Oslo on the afternoon of September 3. CSHRS Vice President and Secretary-general Dong Yunhu was present at the meeting.
基金support in this study.This work was supported by the National Natural Science Foundation of China(82271889,82172105)the National Key Research and Development Program of China(2021YFC2701000)Shanghai Natural Science Foundation(23ZR1409400,24ZR1409400).
文摘Craniofacial microsomia(CFM)is a congenital malformation with maxillary and/or mandibular hypoplasia,skin tags,and ear malformations(Luo et al.,2023).Microtia,in its mildest form,can occur alone(Quiat et al.,2023).With a prevalence of 3.8/100,000(Barisic et al.,2014),CFM is the second most common congenital craniofacial abnormality(Li et al.,2022;Luo et al.,2023).Most cases are sporadic,but familial ones suggest autosomal dominant(AD)or autosomal recessive(AR)(Beleza-Meireles et al.,2014).In 2023,Quiat et al.and Mao et al.successively identified FOXI3 variants in 16 pedigrees and 10 sporadic cases,respectively,accounting for 3.1%of CFM cases(Mao et al.,2023;Quiat et al.,2023).FOX/3 has surpassed SF3B2 as the most frequently identified pathogenic gene for CFM to date(Timberlake et al.,2021;Mao et al.,2023;Quiat et al.,2023).In this study,we performed whole-exome sequencing(WES)on 201 CFM pedigrees and detected FOX/3 variants in 8 AD-inherited pedigrees with 24 patients and 28 unaffected individuals(Fig.1A).
