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Sky luminance distribution types in China 被引量:3
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作者 何荥 毛华松 全利 《Journal of Central South University》 SCIE EI CAS 2012年第3期777-782,共6页
According to Chinese daylighting climate data,combined with the standard of Commission Inernationale de l'Eclairgae(CIE) general sky luminance distribution(SLD),the sky luminance distribution of typical daylightin... According to Chinese daylighting climate data,combined with the standard of Commission Inernationale de l'Eclairgae(CIE) general sky luminance distribution(SLD),the sky luminance distribution of typical daylighting climate zones in China was studied.Through the research on reference SLD of overcast,intermediate and clear types,the standards of clear and overcast SLD are consistent with CIE general sky,and the intermediate SLD has greater error with CIE general sky.The main types of Chinese sky luminance in different daylighting climate zones were obtained,which provide the basic data for simulation and forecast of China natural light,and provide reference for using the standard amendments of China future natural light. 展开更多
关键词 sky luminance distribution sky type DAYLIGHTING
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Graded doped structure fabricated by vacuum spray method to improve the luminance of polymer light-emitting diodes 被引量:1
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作者 X.Mo T.Mizokuro +2 位作者 C.Heck N.Tanigaki T.Hiraga 《Nano-Micro Letters》 SCIE EI CAS 2009年第1期19-22,共4页
An increase in luminance of a polymer light-emitting diode(PLED) was obtained by fabricating a graded doping structure using a vacuum spray method. The small electron transport molecule, Tris(8-hydroxyquinolinato) alu... An increase in luminance of a polymer light-emitting diode(PLED) was obtained by fabricating a graded doping structure using a vacuum spray method. The small electron transport molecule, Tris(8-hydroxyquinolinato) aluminum(III)(Alq3), was graded dispersed along the film in the direction of growth in the hole transport polymer poly(3-hexylthiophene-2,5-diyl)(P3HT, regiorandom) layer of the PLED, despite being dissolved in the same organic solvent as the polymer. The PLED reported here, which is composed of a graded structure, emitted brighter light than PLEDs composed of pure polymer or of a blend of active layers prepared by spin coating and/or vacuum spray methods. 展开更多
关键词 Polymer light-emitting diodes luminance Graded doped Vacuum spray
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An efficient algorithm and FPGA implementation of video luminance transient improvement 被引量:1
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作者 汪彦刚 《High Technology Letters》 EI CAS 2010年第4期359-365,共7页
In this paper, a high-performance and low-complexity luminance transient improvement (LTI) algorithm is proposed and efficiently implemented on field programmable gate army (FPGA) devices, which can be widely used... In this paper, a high-performance and low-complexity luminance transient improvement (LTI) algorithm is proposed and efficiently implemented on field programmable gate army (FPGA) devices, which can be widely used to enhance the sharpness of digital video. The proposed algorithm generates the cor- rection signal by using the difference of the outputs of two Gaussian filters with different variances, and then modulates the correction signal adaptively according to the local contrast information of video frames. A 2-D min/max nonlinear filter is employed to suppress overshoots around edges. The proposed algorithm is thoroughly confirmed by experiments and compared with other algorithms on irrkages, which produces steeper edges and better visual quality while suppressing noise and artifacts. And the hardware architecture suitable for FPGA implementation is optimized based on the property of the algorithm and proves to be effective and efficient in many respects, such as resource consumption, performance and reconfigura- bility. The specific implementation details on both Xilinx and Ahera FPGA devices are also described in this paper. 展开更多
关键词 video enhancement luminance transient improvement (LTI) field programmable gate array (FPGA)
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Neuronal Response to Reward and Luminance in Macaque LIP During Saccadic Choice
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作者 Ziqi Wu Aihua Chen Xinying Cai 《Neuroscience Bulletin》 SCIE CAS CSCD 2023年第1期14-28,共15页
Recent work in decision neuroscience suggests that visual saliency can interact with reward-based choice,and the lateral intraparietal cortex(LIP)is implicated in this process.In this study,we recorded from LIP neuron... Recent work in decision neuroscience suggests that visual saliency can interact with reward-based choice,and the lateral intraparietal cortex(LIP)is implicated in this process.In this study,we recorded from LIP neurons while monkeys performed a two alternative choice task in which the reward and luminance associated with each offer were varied independently.We discovered that the animal’s choice was dictated by the reward amount while the luminance had a marginal effect.In the LIP,neuronal activity corresponded well with the animal’s choice pattern,in that a majority of reward-modulated neurons encoded the reward amount in the neuron’s preferred hemifield with a positive slope.In contrast,compared to their responses to low luminance,an approximately equal proportion of luminance-sensitive neurons responded to high luminance with increased or decreased activity,leading to a much weaker population-level response.Meanwhile,in the non-preferred hemifield,the strength of encoding for reward amount and luminance was positively correlated,suggesting the integration of these two factors in the LIP.Moreover,neurons encoding reward and luminance were homogeneously distributed along the anterior-posterior axis of the LIP.Overall,our study provides further evidence supporting the neural instantiation of a priority map in the LIP in reward-based decisions. 展开更多
关键词 REWARD luminance Attention Priority map Saccadic choice Lateral intraparietal cortex
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A Fundus Photographic Method with Narrow Spectral Band Luminance
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作者 Jia Qu, Guangji Wang, Yuhua Tao, Fan Lu, Mingguang Shi, Xinm Ii, Yongwei Ling Department of Ophthalmology and Optometry, Wenzhou Medical College Wenzhou 325003, China 《眼科学报》 1993年第1期45-48,共4页
We perfected the narrow spectral band fundus photographic system using interference filters at the wavelengths of 417, 478, 500, 530, 547, 570, 589, 607, 628 and 648nm. Tests about the light penetration of filters and... We perfected the narrow spectral band fundus photographic system using interference filters at the wavelengths of 417, 478, 500, 530, 547, 570, 589, 607, 628 and 648nm. Tests about the light penetration of filters and exposure of various brand films were made on this system. Studies of the contrast of fundal tissues and structures under the different narrow spectral band light were made on 43 Chinese fellow eyes. The results indicates that the interference filters of 570 nm have the highest light penetr... 展开更多
关键词 fundus photography monochromatic light FILTER luminance.
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Adaptive luminance adjustment and neighborhood spreading strength information based view synthesis
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作者 Zhizhong Fu Xue Wang +2 位作者 Yuan Li Xiaohui Yang Jin Xu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2016年第3期721-729,共9页
View synthesis is an important building block in three dimension(3D) video processing and communications.Based on one or several views,view synthesis creates other views for the purpose of view prediction(for compr... View synthesis is an important building block in three dimension(3D) video processing and communications.Based on one or several views,view synthesis creates other views for the purpose of view prediction(for compression) or view rendering(for multiview-display).The quality of view synthesis depends on how one fills the occlusion area as well as how the pixels are created.Consequently,luminance adjustment and hole filling are two key issues in view synthesis.In this paper,two views are used to produce an arbitrary virtual synthesized view.One view is merged into another view using a local luminance adjustment method,based on local neighborhood region for the calculation of adjustment coefficient.Moreover,a maximum neighborhood spreading strength hole filling method is presented to deal with the micro texture structure when the hole is being filled.For each pixel at the hole boundary,its neighborhood pixels with the maximum spreading strength direction are selected as candidates;and among them,the pixel with the maximum spreading strength is used to fill the hole from boundary to center.If there still exist disocclusion pixels after once scan,the filling process is repeated until all hole pixels are filled.Simulation results show that the proposed method is efficient,robust and achieves high performance in subjection and objection. 展开更多
关键词 view synthesis three dimension(3D) multiview local luminance correction hole filling maximum spreading strength
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High-fidelity light-field display with enhanced information utilization by modulating chrominance and luminance separately 被引量:2
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作者 Zhaohe Zhang Xunbo Yu +6 位作者 Xin Gao Boyang Liu Hanbo Wang Chao Gao Zeyu Hao Ruiang Zhao Xinzhu Sang 《Light(Science & Applications)》 2025年第3期811-821,共11页
Light-field displays typically consist of a two-dimensional(2D)display panel and a light modulation device.The 2D panel presents synthesized parallax images,with the total information content of the three-dimensional(... Light-field displays typically consist of a two-dimensional(2D)display panel and a light modulation device.The 2D panel presents synthesized parallax images,with the total information content of the three-dimensional(3D)light feld dictated by the panel's total resolution.Angular resolution serves as a critical metric for light-field displays,where higher angular resolution correlates with a more realistic 3D visual experience.However,the improvement of angular resolution is typically accompanied by a reduction in spatial resolution,due to the limitations of the 2D display panel's total resolution.To address this challenge,a light-feld display method with enhanced information utilization is introduced,achieved through the independent modulation of chrominance and luminance.A static light-field image display system is proposed to verify the feasibility of this method.The system employs a bidirectional angular modulation grating(BAMG)and a collimated light source(CLS)to create uniformly distributed viewpoints in space.A luminance modulation film(LMF)and a chrominance modulation film(CMF)are utilized to modulate the light-field information,with chrominance and luminance synthesized images printed at pixel densities of 720 pixels per inch(PPl)and 8000 dots per inch(DPl),respectively,to align with the differential sensitivities of the human visual system.In the experiment,the proposed display system achieves a full-parallax,high-fidelity color display with a 98.2°horizontal and 97.7°vertical field of view(FOV).So,the light-feld display method of modulating chrominance and luminance separately has been proven to achieve high-fidelity display effects. 展开更多
关键词 synthesized parallax imageswith light modulation devicethe chrominance modulation d panel high fidelity light field display luminance modulation angular resolution enhanced information utilization
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基于多序列磁共振组学及临床-病理学特征的联合模型对Luminal型及非Luminal型乳腺癌的诊断价值
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作者 毛锡金 薛莹 王静 《滨州医学院学报》 2025年第2期162-167,共6页
目的探讨基于多序列磁共振组学特征及临床-病理特征的联合模型对Luminal型和非Luminal型乳腺癌的诊断价值。方法收集取得病理诊断结果的202例乳腺癌患者,按照7∶3分层抽样分为训练组和验证组,在磁共振图像手动勾画感兴趣区,并提取磁共... 目的探讨基于多序列磁共振组学特征及临床-病理特征的联合模型对Luminal型和非Luminal型乳腺癌的诊断价值。方法收集取得病理诊断结果的202例乳腺癌患者,按照7∶3分层抽样分为训练组和验证组,在磁共振图像手动勾画感兴趣区,并提取磁共振组学特征。应用方差阈值法和最小绝对收缩和选择算法对数据降维。基于筛选组学特征,采用logistic回归构建模型。同时分析临床-病理特征并构建临床模型。基于磁共振组学评分和临床-病理特征建立联合模型。使用受试者工作特征曲线评估模型的诊断价值。结果磁共振组学模型、临床模型、联合模型在验证组的曲线下面积分别为0.749、0.799、0.844,其中联合模型的诊断效果最佳。决策曲线显示,联合模型更具有临床价值。结论采用多序列磁共振组学和临床-病理特征结合构建联合诊断模型具有较好的诊断价值,有望成为术前鉴别Luminal型和非Luminal型乳腺癌的一种重要无创手段。 展开更多
关键词 Luminal型乳腺癌 影像组学 机器学习 Nomogram模型
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磁共振成像对乳腺实性乳头状癌危险程度的评估价值
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作者 黎鑫乐 伏秋燚 +2 位作者 孙琨 夏冰清 柴维敏 《中国医学计算机成像杂志》 北大核心 2025年第2期186-192,共7页
目的:归纳总结乳腺实性乳头状癌(SPC)的磁共振成像特征,评估术前危险程度。方法:回顾性分析134例手术病理为乳腺SPC(其中原位癌45例,浸润癌89例)的临床、磁共振影像及病理资料。结果:浸润癌肿块直径(中位数)大于原位癌(2.3 cm vs 1.2 cm... 目的:归纳总结乳腺实性乳头状癌(SPC)的磁共振成像特征,评估术前危险程度。方法:回顾性分析134例手术病理为乳腺SPC(其中原位癌45例,浸润癌89例)的临床、磁共振影像及病理资料。结果:浸润癌肿块直径(中位数)大于原位癌(2.3 cm vs 1.2 cm,P<0.001)。浸润癌相对原位癌病灶弥散加权成像(DWI)高信号[对应表观弥散系数(ADC)图低信号]者所占比例更高(56/60 vs 12/19,P=0.001)。原位癌肿块以均匀强化为主,浸润癌肿块以不均匀强化为主(P=0.001)。浸润癌肿块伴周围非肿块强化较原位癌更多见(P=0.037)。表现为非肿块强化的浸润癌相对原位癌病灶T2呈高信号者所占比例更高(19/29 vs 10/26,P=0.047)。原位癌均无淋巴结转移,7例浸润癌伴淋巴结转移(2例前哨淋巴结转移,5例腋窝淋巴结转移,1例内乳淋巴结转移)。所有乳腺SPC均是Luminal分型。结论:肿块大小、病灶DWI高信号(对应ADC图低信号)、肿块的强化方式、肿块伴非肿块强化、非肿块T2W高信号、淋巴结转移阳性等是评估乳腺SPC危险程度的关键信息。 展开更多
关键词 乳腺实性乳头状癌 磁共振成像 Luminal分型
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Luminal B型乳腺癌组织中XAF1、PCK1表达及与病人预后的关系 被引量:1
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作者 严萍萍 张绍东 +1 位作者 郭皎亮 窦燕东 《临床外科杂志》 2025年第1期97-101,共5页
目的探讨Luminal B型乳腺癌组织中X染色体连锁凋亡抑制蛋白相关因子1(XAF1)、磷酸烯醇丙酮酸羧激酶1(PCK1)表达及与病人预后的关系。方法2016年1月~2018年1月Luminal B型乳腺癌病人95例,均行手术治疗,术中收集癌组织及距离癌组织>5 c... 目的探讨Luminal B型乳腺癌组织中X染色体连锁凋亡抑制蛋白相关因子1(XAF1)、磷酸烯醇丙酮酸羧激酶1(PCK1)表达及与病人预后的关系。方法2016年1月~2018年1月Luminal B型乳腺癌病人95例,均行手术治疗,术中收集癌组织及距离癌组织>5 cm的癌旁组织,免疫组化法检测组织中XAF1、PCK1蛋白阳性表达情况。分析XAF1、PCK1蛋白表达与乳腺癌临床病理特征关系,采用Kaplan-Meier法绘制不同XAF1、PCK1蛋白表达乳腺癌病人的生存曲线,生存率的比较采用Log-rank检验,多因素Cox回归分析影响乳腺癌预后的相关因素。结果GEPIA数据库分析显示,乳腺癌组织中XAF1、PCK1 mRNA表达水平均低于正常组织,差异有统计学意义(P<0.05)。癌组织XAF1、PCK1蛋白阳性表达率分别低于癌旁组织,差异有统计学意义(P<0.05)。乳腺癌组织XAF1阳性表达与临床分期、淋巴结发生转移及组织学分级、Ki-67表达状态有关,PCK1阳性表达与临床分期、淋巴结发生转移及Ki-67表达状态有关(P<0.05)。XAF1阳性表达者5年总生存率高于阴性表达(Log-rank χ^(2)=5.101,P=0.024),PCK1阳性表达病人5年总生存率高于阴性表达(Log-rank χ^(2)=6.515,P=0.011)。临床分期Ⅲ期、XAF1阴性表达、PCK1阴性表达是不良预后的危险因素(P<0.05)。结论XAF1和PCK1在Luminal B型乳腺癌组织中阳性表达率降低,与部分临床病理特征及术后5年生存率有关,XAF1、PCK1阴性表达者术后5年生存率较差。 展开更多
关键词 乳腺癌 Luminal B型 X染色体连锁凋亡抑制蛋白相关因子1 磷酸烯醇丙酮酸羧激酶1 预后
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T1-2N1-2M0期luminal型乳腺癌新辅助化疗与辅助化疗后的预后及其影响因素分析
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作者 张燃 陈虹羽 +2 位作者 蒲卓 刘军 赵小波 《中国普外基础与临床杂志》 2025年第8期984-990,共7页
目的对比T1-2N1-2M0期luminal型乳腺癌患者新辅助化疗(neoadjuvant chemotherapy,NAC)与辅助化疗(adjuvant chemotherapy,AC)后的预后差异并分析影响预后的因素。方法回顾性收集2014年1月至2019年12月期间就诊于川北医学院附属医院具有... 目的对比T1-2N1-2M0期luminal型乳腺癌患者新辅助化疗(neoadjuvant chemotherapy,NAC)与辅助化疗(adjuvant chemotherapy,AC)后的预后差异并分析影响预后的因素。方法回顾性收集2014年1月至2019年12月期间就诊于川北医学院附属医院具有完整随访资料且符合纳入标准的luminal型乳腺癌患者,NAC与AC均使用基于蒽环类药物的化疗方案。采用Kaplan-Meier法绘制的生存曲线进行生存分析,同时采用Cox比例风险回归(简称“Cox回归”)分析影响5年累积总生存率的风险因素。检验水准α=0.05。结果共纳入符合纳入标准的luminal型乳腺癌患者206例(NAC者99例、AC者107例),其中luminal A型101例(AC者57例、NAC者44例),luminal B型105例(AC者50例、NAC者55例)。中位随访72.5个月时,全患者中行AC和NAC患者的5年累积总生存率的差异无统计学意义(89.7%比88.9%,P=0.571),然而行AC者的5年累积无病生存率高于行NAC患者(85.0%比73.5%,P<0.001)。亚组分析结果显示,luminal A型和B型患者中行AC和NAC患者的5年累积总生存率比较差异均无统计学意义(94.7%比86.4%,P=0.727;84.0%比89.3%,P=0.864);而luminal A型患者中行AC者的5年累积无病生存率高于行NAC患者(93.0%比77.3%,P<0.001),但在luminal B型患者中行AC和NAC患者的5年累积无病生存率的差异无统计学意义(74.0%比71.4%,P=0.201)。多因素Cox回归分析结果显示,N2分期[HR(95%CI)=2.290(1.249,4.196)]、有脉管癌栓[HR(95%CI)=2.181(1.182,4.026)]、未行内分泌治疗[HR(95%CI)=6.013(2.590,13.965)]、NAC后未达病理完全缓解[HR(95%CI)=2.403(1.284,4.496)]为影响T1-2N1-2M0期luminal型乳腺癌患者5年累积总生存率的独立危险因素。结论本研究结果提示,T1-2N1-2M0期luminal型乳腺癌患者能从AC中获得更高的无病生存率,但仍需综合考虑患者的病情比如淋巴结转移、脉管癌栓等因素,制定个体化治疗方案,以提高患者的总生存率。 展开更多
关键词 luminal型乳腺癌 新辅助化疗 辅助化疗 预后
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病例队列设计下新疆地区Luminal B型乳腺癌患者生存预后分析
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作者 吴梦娟 高春洁 +2 位作者 张涛 赵婷 王蕾 《宁夏医科大学学报》 2025年第3期283-290,共8页
目的探讨新疆地区Luminal B型乳腺癌患者生存预后的影响因素。方法回顾性分析2015—2019年新疆医科大学附属肿瘤医院Luminal B型乳腺癌患者的临床数据,基于病例队列设计下加权Cox比例风险模型确定患者的独立预后因素并构建列线图;以全... 目的探讨新疆地区Luminal B型乳腺癌患者生存预后的影响因素。方法回顾性分析2015—2019年新疆医科大学附属肿瘤医院Luminal B型乳腺癌患者的临床数据,基于病例队列设计下加权Cox比例风险模型确定患者的独立预后因素并构建列线图;以全队列样本作为验证集进行外部验证,使用受试者工作特征(ROC)曲线、校准曲线以及临床决策曲线(DCA)评估模型的有效性以及临床实用性。结果单因素及多因素加权Cox比例风险模型结果显示,ER表达[HR=0.268,95%CI(0.118,0.607)]、PR表达[HR=0.599,95%CI(0.369,0.973)]、HER-2表达[HR=1.571,95%CI(1.044,2.366)]、临床分期Ⅱ期[HR=2.533,95%CI(1.460,4.394)]、Ⅲ期[HR=5.437,95%CI(3.101,9.534)]以及Ⅳ期[HR=21.359,95%CI(9.933,45.929)]接受术后治疗[HR=0.546,95%CI(0.375,0.795)]及保乳术[HR=0.366,95%CI(0.175,0.764)]、根治术[HR=0.536,95%CI(0.314,0.913)]是Luminal B型乳腺癌患者独立预后因素(P均<0.05)。通过纳入以上变量构建并验证预测患者1、4、7年总生存率的列线图,ROC曲线、校准曲线以及DCA曲线在病例队列与全队列样本中均证实该列线图具有良好的区分度、校准度以及临床实用性。结论基于病例队列设计下加权Cox比例风险模型构建的列线图对新疆Luminal B型乳腺癌患者的生存预后具有良好的预测价值,能够为个性化诊疗提供科学依据。 展开更多
关键词 乳腺癌 Luminal B型 病例队列设计 生存预后 列线图
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pH响应聚合物胶束重塑PIK3CA突变Luminal型乳腺癌免疫微环境
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作者 杨晨举 王斯雷 +5 位作者 陈桂冬 王钒臣 李星晨 徐琳琳 史林启 于津浦 《中国肿瘤临床》 北大核心 2025年第6期271-278,共8页
目的:探讨PIK3CA突变对Luminal型乳腺癌免疫微环境的影响,以及pH响应性聚合物胶束依赖的药物靶向递送重塑PIK3CA突变Luminal型乳腺癌肿瘤免疫微环境的作用。方法:采用生物信息学分析PIK3CA在乳腺癌中的突变特点;构建PIK3CA突变的Lumina... 目的:探讨PIK3CA突变对Luminal型乳腺癌免疫微环境的影响,以及pH响应性聚合物胶束依赖的药物靶向递送重塑PIK3CA突变Luminal型乳腺癌肿瘤免疫微环境的作用。方法:采用生物信息学分析PIK3CA在乳腺癌中的突变特点;构建PIK3CA突变的Luminal型乳腺癌小鼠移植瘤模型,通过单细胞质谱流式技术(mass cytometry,CyTOF)探究肿瘤免疫微环境的变化;收集2004年8月至2008年12月天津医科大学肿瘤医院62例Luminal型乳腺癌患者(BRCA cohort)组织样本,在组织水平探索PIK3CA突变与肿瘤免疫微环境的关系;负载Alpelisib的pH响应性聚合物胶束(Alpelisib@MSPM)的制备和表征鉴定;动物实验探究Alpelisib@MSPM对PIK3CA突变Luminal型乳腺癌的治疗效果。结果:PIK3CA是乳腺癌中最常见的突变基因之一,尤其在Luminal型乳腺癌中,其突变频率最高;通过CyTOF分析发现在PIK3CA突变乳腺癌移植瘤中PIK3CA突变可以驱动肿瘤免疫抑制微环境的形成;多重荧光免疫组织化学分析发现PIK3CA突变显著影响乳腺癌免疫微环境,呈现骨髓来源抑制细胞(myeloid-derived suppressor cells,MDSCs)高浸润和CD8+T细胞低浸润现象;成功制备负载Alpelisib的pH响应性聚合物胶束,胶束的平均粒径约127 nm;经Alpelisib和Alpelisib@MSPM治疗后,PIK3CA突变的Luminal型乳腺癌小鼠肿瘤生长缓慢,肿瘤免疫微环境中MDSCs的比例明显降低,CD8_+T细胞的比例显著升高,并且在Alpelisib@MSPM组中治疗效果更加显著。结论:PIK3CA突变驱动Luminal型乳腺癌免疫抑制微环境的形成,pH响应性聚合物胶束依赖的Alpelisib靶向递送能够显著增强乳腺癌的治疗效果。 展开更多
关键词 Luminal型乳腺癌 PIK3CA MDSCS 聚合物胶束
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pT1-2N1M0乳腺癌不同分子亚型的临床病理特征及对放疗的指导价值
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作者 余思婷 王军 +1 位作者 刘磊 罗婷 《华西医学》 2025年第1期42-47,共6页
目的探索不同分子亚型在pT1-2N1M0乳腺癌患者中的预后差异及对术后放疗的决策作用。方法回顾性分析2008年—2018年四川大学华西医院就诊的1526例pT1-2N1M0乳腺癌患者的临床病理资料。运用χ^(2)检验分析不同分子亚型患者的基线分布差异... 目的探索不同分子亚型在pT1-2N1M0乳腺癌患者中的预后差异及对术后放疗的决策作用。方法回顾性分析2008年—2018年四川大学华西医院就诊的1526例pT1-2N1M0乳腺癌患者的临床病理资料。运用χ^(2)检验分析不同分子亚型患者的基线分布差异,运用Kaplan-Meier生存分析和对数秩检验绘制生存曲线和分析比较各亚型患者的总生存(overall survival,OS)率和乳腺癌特异性生存(breast cancer-specific survival,BCSS)率,运用Cox回归模型分析Luminal分型以及根治术后放疗与否等临床病理特征与乳腺癌根治术后患者生存情况的关系。结果在1526例pT1-2N1M0乳腺癌患者中,Luminal A型共674例(44.2%),Luminal B型530例(34.7%),人表皮生长因子受体2(human epidermal growth factor receptor 2,Her-2)过表达型174例(11.4%),三阴性148例(9.7%)。Luminal A、Luminal B、Her-2过表达型和三阴性4种分子亚型患者5年OS率分别为98.6%、94.3%、95.5%和91.2%(χ^(2)=11.712,P=0.001),5年BCSS率分别为99.3%、94.6%、95.5%和92.5%(χ^(2)=18.547,P<0.001)。多因素Cox回归分析提示是否绝经[风险比=0.483,95%置信区间(0.253,0.923),P=0.028]以及是否内分泌治疗[风险比=2.021,95%置信区间(1.012,4.034),P=0.046]是影响pT1-2N1M0乳腺癌患者术后5年OS率的预后因素,尚不能认为Luminal分型和术后放疗是影响该部分患者术后5年OS率的预后因素(P>0.05)。结论在pT1-2N1M0乳腺癌患者中,三阴性患者5年OS率及5年BCSS率最低,Luminal分型、术后放疗与否与患者术后生存情况的关系,今后还需进一步研究。 展开更多
关键词 乳腺癌 Luminal分型 临床病理特征 生存分析 放射治疗
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Green perovskite light-emitting diodes with simultaneous high luminance and quantum efficiency through charge injection engineering 被引量:2
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作者 Tiankai Zhang Mingzhu Long +6 位作者 Lingxiang Pan Kwanho Ngai Minchao Qin Fangyan Xie Xinhui Lu Jian Chen Jianbin Xu 《Science Bulletin》 SCIE EI CAS CSCD 2020年第21期1832-1839,M0004,共9页
Metal halide perovskite light emitting diodes(PeLEDs)have recently experienced rapid development due to the tunable emission wavelengths,narrow emission linewidth and low material cost.To achieve stateof-the-art perfo... Metal halide perovskite light emitting diodes(PeLEDs)have recently experienced rapid development due to the tunable emission wavelengths,narrow emission linewidth and low material cost.To achieve stateof-the-art performance,the high photoluminescence quantum yield(PLQY)of the active emission layer,the balanced charge injection,and the optimized optical extraction should be considered simultaneously.Multiple chemical passivation strategies have been provided as controllable and efficient methods to improve the PLQY of the perovskite layer.However,high luminance under large injection current and high external quantum efficiency(EQE)can hardly be achieved due to Auger recombination at high carrier density.Here,we decreased the electron injection barrier by tuning the Fermi-level of the perovskite,leading to a reduced turn on voltage.Through molecular doping of the hole injection material,a more balanced hole injection was achieved.At last,a device with modified charge injection realizes high luminance and quantum efficiency simultaneously.The best device exhibits luminance of 55,000 cd m^-2 EQE of 8.02%at the working voltage of 2.65 V,current density of 115 mA cm^-2,and shows EQE T50 stability around 160 min at 100 mA cm^-2 injection current density. 展开更多
关键词 Perovskite LED High luminance Structure design Balanced charge injection Molecular doping
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Estimation of tunneling effect caused by luminance non-uniformity in head-up displays 被引量:2
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作者 Vinod Karar Smarajit Ghosh 《Chinese Optics Letters》 SCIE EI CAS CSCD 2014年第1期73-78,共6页
Head-up displays (HUDs) enable a pilot to manage aircraft activities by facilitating simultaneous access to the flight instrument data and to the outside scene. However, HUDs can also distract a pilot. This study sh... Head-up displays (HUDs) enable a pilot to manage aircraft activities by facilitating simultaneous access to the flight instrument data and to the outside scene. However, HUDs can also distract a pilot. This study shows that HUD luminance non-uniformity may force inappropriate distribution of attention between the events shown on HUD symbology and the outside scene because of the resultant differential contrast in the display area. Results of statistical analysis demonstrate considerable effects of HUD image luminance and ambient luminance, as well as their interaction, on the detection of events displayed on an HUD and the outside scene. 展开更多
关键词 Estimation of tunneling effect caused by luminance non-uniformity in head-up displays HEAD
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光谱CT联合MRI的多模态影像学模型在鉴别Luminal型乳腺癌中的价值
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作者 吴郑鑫 周兆良 +3 位作者 杨盼盼 董书杉 王世威 张睿馨 《浙江医学》 2025年第20期2176-2181,共6页
目的探讨光谱CT联合MRI在鉴别Luminal型与非Luminal型乳腺癌中的价值。方法回顾性收集2024年2月至2025年4月浙江中医药大学附属第一医院收治的110例乳腺癌患者,按照免疫组织化学染色结果分为Luminal型(82例)与非Luminal型(28例)两组。... 目的探讨光谱CT联合MRI在鉴别Luminal型与非Luminal型乳腺癌中的价值。方法回顾性收集2024年2月至2025年4月浙江中医药大学附属第一医院收治的110例乳腺癌患者,按照免疫组织化学染色结果分为Luminal型(82例)与非Luminal型(28例)两组。所有患者术前均接受光谱CT胸部平扫和MRI增强扫描检查,记录有效原子序数值(Zeff)、电子云密度(EDW)、40 keV时的CT值(40 keV MonoE)和100 keV时的CT值(100 keV MonoE),计算光谱曲线斜率(K);阅读MRI图像,记录病灶边缘、病灶形态、肿瘤最大径和表观扩散系数(ADC)值,计算时间信号强度曲线,记录曲线类型。比较两组患者的光谱CT参数和MRI参数。使用单因素和多因素logistic回归分析筛选鉴别Luminal型乳腺癌的独立预测因素,构建多模态联合模型。绘制ROC曲线评估模型的诊断效能。结果Luminal型和非Luminal型乳腺癌患者年龄、月经史、肿瘤最大径、ADC、40 keV MonoE、100 keV MonoE和EDW比较,差异均有统计学意义(均P<0.05)。肿瘤最大径、ADC值和EDW是鉴别Luminal型和非Luminal型乳腺癌的独立预测因素。ROC曲线显示,相比于单一模态,基于光谱CT和MRI联合的多模态模型的诊断效能较好(AUC=0.867,灵敏度为0.854,特异度为0.714)。结论利用光谱CT联合MRI构建的多模态影像学模型在鉴别Luminal型和非Luminal型乳腺癌中具有一定潜力,可以为临床诊疗提供参考依据。 展开更多
关键词 乳腺肿瘤 光谱CT MRI Luminal型 非Luminal型
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基于SEER数据库的Luminal型乳腺癌骨转移预后因素分析及构建预测模型
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作者 白子尧 王玮韬 +1 位作者 贾伟 何涛 《内蒙古医学杂志》 2025年第1期16-27,31,共13页
目的通过回顾性分析Luminal型乳腺癌患者的临床资料,确定影响患者预后的危险因素并构建预后模型,评估模型在临床实践中的适用性。方法使用SEER数据库数据,纳入Luminal型乳腺癌骨转移患者的临床资料,包括年龄、婚姻状况、种族、肿瘤位置... 目的通过回顾性分析Luminal型乳腺癌患者的临床资料,确定影响患者预后的危险因素并构建预后模型,评估模型在临床实践中的适用性。方法使用SEER数据库数据,纳入Luminal型乳腺癌骨转移患者的临床资料,包括年龄、婚姻状况、种族、肿瘤位置、组织学分级、偏侧、病理类型、TNM分期、肿瘤大小、手术情况、放化疗情况、分子分型和其他器官转移情况等。将患者数据按照7:3随机分为训练组和验证组,采用R软件进行数据处理和分析,通过单因素和多因素COX回归分析确定影响患者总生存期(OS)、特异性生存期(CSS)的独立危险因素并构建预后模型,最后对模型使用ROC曲线、校准曲线和DCA曲线进行检验和内部验证。结果多因素分析发现影响Luminal型乳腺癌骨转移OS的独立危险因素有:年龄、婚姻状况、种族、组织分级、偏侧、病理类型、肿瘤大小、手术情况、化疗情况、分子分型、其他器官转移情况(P<0.05)。影响Luminal型乳腺癌骨转移CSS的独立危险因素有:年龄、婚姻状况、种族、肿瘤位置、组织分级、病理类型、肿瘤大小、手术情况、化疗情况、分子分型、其他器官转移情况(P<0.05)。纳入相关独立危险因素构建Luminal型乳腺癌骨转移OS、CSS的预测模型,经ROC曲线、校准曲线和DCA曲线检验有较好的准确性和一致性,内部验证组得到相同结果。结论(1)本研究确定了Luminal型乳腺癌骨转移OS和CSS的独立危险因素;(2)发现手术、化疗可以改善骨转移患者的预后;(3)本研究构建的预后模型能够有效预测Luminal型乳腺癌患者的OS和CSS,为临床决策提供了有力支持。 展开更多
关键词 Luminal型乳腺癌 骨转移 预测模型
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Luminal A型乳腺癌患者腋窝淋巴结转移的影响因素及其列线图预测模型构建 被引量:1
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作者 高欣然 贾葆青 +1 位作者 郭佳欣 刘俊彪 《疑难病杂志》 2025年第3期303-308,共6页
目的探讨Luminal A型乳腺癌患者腋窝淋巴结转移(ALNM)的影响因素及其列线图预测模型构建。方法选取2019年1月-2024年1月内蒙古自治区人民医院乳腺肿瘤外科收治的Luminal A型乳腺癌患者135例为研究对象,按照7∶3比例将其分为建模组94例... 目的探讨Luminal A型乳腺癌患者腋窝淋巴结转移(ALNM)的影响因素及其列线图预测模型构建。方法选取2019年1月-2024年1月内蒙古自治区人民医院乳腺肿瘤外科收治的Luminal A型乳腺癌患者135例为研究对象,按照7∶3比例将其分为建模组94例与验证组41例,根据术后是否发生ALNM将建模组患者分为ALNM亚组43例和无ALNM亚组51例。多因素Logistic回归分析Luminal A型乳腺癌患者发生ALNM的影响因素;采用R软件构建列线图模型;受试者工作特征(ROC)曲线评估列线图模型预测Luminal A型乳腺癌患者ALNM的区分度;临床决策曲线(DCA)评估列线图模型的临床应用价值。结果135例Luminal A型乳腺癌患者ALNM发生率为45.19%(61/135),94例建模组患者ALNM发生率为45.74%(43/94)。ALNM亚组患者年龄<50岁、肿瘤最大径>2 cm、组织学分级Ⅱ~Ⅲ级、脉管侵犯、多灶性肿瘤、p53基因突变比例高于无ALNM亚组(χ^(2)=15.474、12.163、14.026、12.983、21.803、15.159,P均<0.001);多因素Logistic回归分析显示,年龄<50岁、肿瘤最大径>2 cm、组织学分级Ⅱ~Ⅲ级、脉管侵犯、多灶性肿瘤、p53基因突变是Luminal A型乳腺癌患者ALNM的独立危险因素[OR(95%CI)=2.531(1.336~4.975)、3.120(1.095~8.886)、3.657(1.602~8.346)、5.208(1.854~14.633)、14.718(2.073~104.485)、6.807(1.934~19.157)],并构建列线图预测模型;ROC曲线验证结果显示,建模组曲线下面积(AUC)为0.960(95%CI=0.916~0.999),验证组AUC为0.967(95%CI=0.918~0.999)。建模组与验证组校准曲线斜率均接近1,建模组H-L检验为χ^(2)=7.067(P=0.701),验证组H-L检验为χ^(2)=6.923(P=0.706);由DCA曲线可知,高风险阈值概率在0.08~0.96时,该列线图模型评估Luminal A型乳腺癌患者ALNM的临床使用价值较高。结论年龄<50岁、肿瘤最大径>2 cm、组织学分级Ⅱ~Ⅲ级、脉管侵犯、多灶性肿瘤、p53基因突变是Luminal A型乳腺癌患者ALNM的危险因素,以此构建的列线图模型对预测Luminal A型乳腺癌患者ALNM有一定的临床价值。 展开更多
关键词 乳腺癌 Luminal A型 腋窝淋巴结转移 影响因素 列线图
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不同分子亚型同时性原发性双侧乳腺癌合并骨转移1例
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作者 黄小辉 唐林 +4 位作者 周围 王紫娟 王桃丽 连红月 谭米多 《肿瘤药学》 2025年第2期269-274,共6页
目的探究不同分子亚型同时性原发性双侧乳腺癌(SPBBC)合并骨转移的临床特征及治疗,以期为该病的早期诊治提供参考依据。方法回顾性分析我院收治的1例不同分子亚型SPBBC合并骨转移病例的诊疗过程并进行文献复习。结论不同分子亚型SPBBC... 目的探究不同分子亚型同时性原发性双侧乳腺癌(SPBBC)合并骨转移的临床特征及治疗,以期为该病的早期诊治提供参考依据。方法回顾性分析我院收治的1例不同分子亚型SPBBC合并骨转移病例的诊疗过程并进行文献复习。结论不同分子亚型SPBBC合并骨转移的机制仍待进一步阐明,早期诊断和治疗至关重要,需多学科会诊,制定个体化治疗方案。 展开更多
关键词 同时性原发性双侧乳腺癌 不同分子亚型 Luminal B 骨转移 内分泌治疗 HER2
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