An efficient catalytic system was developed to remove various organic pollutants by simultaneously using low-level cobalt ions,calcium carbonate micro-particles and peroxymonosulfate(PMS).A simple base-induced precipi...An efficient catalytic system was developed to remove various organic pollutants by simultaneously using low-level cobalt ions,calcium carbonate micro-particles and peroxymonosulfate(PMS).A simple base-induced precipitation was used to successfully loaded Co-centered reactive sites onto the surface of CaCO_(3)microparticles.Under optimal conditions at 25°C,10 mg/L methylene blue(MB)could be completely degraded within 10 min with 480μg/L Co^(2+),0.4 g/L CaCO_(3)microparticles(or 0.4 g/L Co@CaCO_(3))and 0.1 g/L PMS.The MB degradation followed the pseudo first order kinetics with a rate constant of 0.583 min^(−1),being 8.3,11.5 and 53.0 times that by using Co-OH(0.07 min^(−1)),Co^(2+)(0.044 min^(−1))and CaCO_(3)(0.011 min^(−1))as the catalyst,respectively.It was confirmed that there was a synergistic effect in the catalytic activity between Co species and the CaCO_(3)particles but the major contributor was the highly dispersed Co species.When Co^(2+)-containing simulated electroplating wastewater was used as the Co^(2+)source,not only the added MB was also completely degraded within 5 min in this catalytic system,but also the coexisting heavy metal ions were substantially removed.The presently developed method was applied to simultaneously treat organic wastewater and heavy metals wastewater.The present method was also successfully used to efficiently degrade other organic pollutants including bisphenol A,sulfamethoxazole,rhodamine B,tetrabromobisphenol A,ofloxacin and benzoic acid.A catalytic mechanism was proposed for the PMS activation by Co@CaCO_(3).The surface of CaCO_(3)particles favors the adsorption of Co^(2+).More importantly,the surface of CaCO_(3)particles provides plentiful surface-OH and-CO_(3)^(2+),and these surface groups complex with Co^(2+)to producemore catalytically active species such as surface[CoOH]^(−),resulting in rapid Co^(2+)/Co^(3+)cycling and electron transfer.These interactions cause the observed synergistic effect between Co species and CaCO_(3)particles in PMS activation.Due to good cycle stability,strong anti-interference ability and wide universality,the new method will have broad application prospects.展开更多
We show that low-level jets(LLJs)occurred in 11 out of 22 radiosonde profiles in late austral summer over the coastal region of the Amundsen Sea Embayment,with ten of the LLJs directed offshore.The LLJs had core speed...We show that low-level jets(LLJs)occurred in 11 out of 22 radiosonde profiles in late austral summer over the coastal region of the Amundsen Sea Embayment,with ten of the LLJs directed offshore.The LLJs had core speeds from 9 to 32 m s^(-1),jet core heights from 80 to 800 m,and were associated with strong,low-level temperature inversions.Seven of the observed offshore LLJs were reasonably simulated by the polar-optimized Weather Research and Forecasting(Polar WRF)model,with output from the model subsequently used to elucidate their generation mechanisms.This study shows that one of the offshore LLJs simulated by the Polar WRF was caused by katabatic winds,while the remaining six were caused by the enhancement of katabatic winds by synoptic forcing in response to a low-pressure system over the Bellingshausen Sea,i.e.,the offshore wind component associated with this system plays a crucial role in the enhancement of the katabatic LLJ.Examination of the Polar WRF output further shows that the LLJs extended over large areas of the Amundsen Sea Embayment,resulting in substantially enhanced near-surface wind speeds over both the Thwaites and Pine Island ice shelves,as well as the open ocean over the continental shelf.The wind-driven forcing associated with the LLJs could perhaps have important impacts on the redistribution of snow over the ice shelves significantly,as well as to affecting sea-ice and ocean circulation variability,including the transport of relatively warm water over the continental shelf to the ice shelf cavities and extension basal melting.展开更多
This study examines low-level jets(LLJs)across Northeastern China during both warm(June-September)and cold seasons(December-March)from 1957 to 2021,using fifth generation of the European Centre for Medium-Range Weathe...This study examines low-level jets(LLJs)across Northeastern China during both warm(June-September)and cold seasons(December-March)from 1957 to 2021,using fifth generation of the European Centre for Medium-Range Weather Forecasts reanalysis data with 25-km resolution.LLJs manifest in two prominent regions,one along the leeward flank of the Da Hinggan Ling Mountains in the cold season and another at the center of Northeastern China in the warm season.The intricate interplay between ambient circulation and terrain shapes LLJ distribution,altitudes,wind directions,diurnal cycles,and seasonal diversities.During the warm season,prevailing southwesterly LLJs are found at 925 hPa,while the cold season features stronger and more frequent northwesterly LLJs at 875 hPa.Analysis of the diurnal patterns reveals distinctive behaviors of LLJs in the cold and warm seasons.During the warm season,the single peak in LLJ occurrence emerges around midnight;conversely,in the cold season,LLJs are most frequent shortly before midnight,with an additional sub-peak in the morning.A momentum budget analysis establishes mechanisms underlying these two distinct diurnal variations.In both seasons,the diurnal variation of LLJs is predominately driven by an inertial oscillation and mountain-valley circulations.However,the sub-peak observed in the cold-season morning arises from the thermodynamic and dynamic interaction between the low-level atmosphere and complex terrain.展开更多
Objective Evidence that long-term exposure to ambient air pollution increases mortality among older adults,particularly those residing in low-level air pollution locations,remains scarce.This study investigated the po...Objective Evidence that long-term exposure to ambient air pollution increases mortality among older adults,particularly those residing in low-level air pollution locations,remains scarce.This study investigated the potential links between long-term low-level air pollution exposure and mortality among Chinese older adults.Methods A population-based study with 317,464 individuals aged≥65 years was conducted in Shenzhen,China during 2018 and 2020.Logistic regression models were used to analyze the associations between long-term exposure to air pollution and all-cause mortality,as the primary outcome,as well as non-accidental,cancer and cardiovascular mortality.Results Significant associations of PM1,PM_(2.5),PM_(10),SO_(2),CO,and O3 exposures with a higher risk of all-cause mortality were found.Adjusted odds ratio(OR)for each 1μg/m^(3) increment was 1.49[95%confidence interval(CI):1.46,1.53]for PM1,1.30(1.27,1.32)for PM_(2.5),1.05(1.04,1.06)for PM_(10),5.84(5.39,6.32)for SO_(2),1.04(1.04,1.05)for CO,and 1.02(1.00,1.03)for O3,respectively.Long-term PM1,PM_(2.5),PM_(10),SO_(2),and CO exposures also elevated the risks of non-accidental,cancer and cardiovascular mortality.Conclusion Long-term low-level air pollution exposure was associated with an increased mortality risk among Chinese older adults.展开更多
In contrast to the Pacific and Atlantic Oceans,the Indian Ocean has lacked in-situ observations of wind profiles over open sea areas for decades.In 2021,a shipborne coherent Doppler lidar(CDL)was used to observe in-si...In contrast to the Pacific and Atlantic Oceans,the Indian Ocean has lacked in-situ observations of wind profiles over open sea areas for decades.In 2021,a shipborne coherent Doppler lidar(CDL)was used to observe in-situ wind profiles in the eastern tropical Indian Ocean.This equipment successfully captured low-level jets(LLJs)in the region,and their characteristics were thoroughly analyzed.Results reveal that the observed wind speed of LLJs in the eastern Indian Ocean ranges from 6 m s^(-1) to 10 m s^(-1) during the boreal winter and spring seasons,showing a height range of 0.6 to 1 km and two peak times at 0800 and 2000 UTC.This wind shear is weaker than that in land or offshore areas,ranging from 0 s^(-1) to 0.006 s^(-1).Moreover,the accuracy of the CDL data is compared to that of ERA5 data in the study area.The results indicate that the zonal wind from ERA5 data significantly deviated from the CDL measurement data,and the overall ERA5 data are substantially weaker than the in-situ observations.Notably,ERA5 underestimates northwestward LLJs.展开更多
Chronic hepatitis B virus(HBV)infection(CHB)is a public health concern worldwide.Current therapies utilizing nucleos(t)ide analogs(NA)have not resulted in a complete cure for CHB.Furthermore,patients on long-term NA t...Chronic hepatitis B virus(HBV)infection(CHB)is a public health concern worldwide.Current therapies utilizing nucleos(t)ide analogs(NA)have not resulted in a complete cure for CHB.Furthermore,patients on long-term NA treatment often develop low-level viremia(LLV).Persistent LLV,in addition to causing the progression of liver disease or hepatocellular carcinoma,may shed light on the current plight of NA therapy.Here,we review the literature on LLV,NA treatment,and various doses of entecavir to find a strategy for improving the efficacy of this antiviral agent.For LLV patients,three therapeutic options are available,switching to another antiviral monotherapy,interferon-αswitching therapy,and continuing monotherapy.In real-world clinical practice,entecavir overdose has been used in antiviral therapy for CHB patients with NA refractory and persistent LLV,which encouraged us to conduct further in-depth literature survey on dosage and duration related entecavir studies.The studies of pharmacodynamics and pharmacokinetics show that entecavir has the maximal selected index for safety,and has great potential in inhibiting HBV replication,in all of the NAs.In the particular section of the drug approval package published by the United States Food and Drug Administration,entecavir doses 2.5-20 mg/d do not increase adverse events,and entecavir doses higher than 1.0 mg/d might improve the antiviral efficacy.The literature survey led us to two suggestions:(1)Increasing entecavir dose to 1.0 mg/d for the treatment of NA naïve patients with HBV DNA>2×106 IU/mL is feasible and would provide better prognosis;and(2)Further research is needed to assess the long-term toxic effects of higher entecavir doses(2.5 and 5.0 mg/d),which may prove beneficial in treating patients with prior NA treatment,partial virological response,or LLV state.展开更多
The diurnal variation of precipitation over the Dabie Mountains(DBM) in eastern China during the 2013 mei-yu season is investigated with forecasts of a regional convection-permitting model. Simulated precipitation is ...The diurnal variation of precipitation over the Dabie Mountains(DBM) in eastern China during the 2013 mei-yu season is investigated with forecasts of a regional convection-permitting model. Simulated precipitation is verified against surface rain-gauge observations. The observed morning precipitation peak on the windward(relative to the prevailing synoptic-scale wind) side of the DBM is reproduced with good spatial and temporal accuracy. The interaction between the DBM and a nocturnal boundary layer low-level jet(BLJ) due to the inertial oscillation mechanism is shown to be responsible for this precipitation peak. The BLJ is aligned with the lower-level southwesterly synoptic-scale flow that carries abundant moisture.The BLJ core is established at around 0200 LST upwind of the mountains. It moves towards the DBM and reaches maximum intensity at about 70 km ahead of the mountains. When the BLJ impinges upon the windward side of the DBM in the early morning, mechanical lifting of moist air leads to condensation and subsequent precipitation.展开更多
Three-month wind profiles, 260 m PM_1 concentrations [i.e., particulate matter(PM) with an aerodynamic diameter ≤1μm], and carrier-to-noise ratio data at two Beijing sites 55 km apart(urban and suburban) were collec...Three-month wind profiles, 260 m PM_1 concentrations [i.e., particulate matter(PM) with an aerodynamic diameter ≤1μm], and carrier-to-noise ratio data at two Beijing sites 55 km apart(urban and suburban) were collected to analyze the characteristics of low-level nocturnal wind and PM in autumn and winter. Three mountain-plain wind events with wind shear were selected for analysis. The measurements indicated that the maximum wind speeds of the northerly weak low-level jet(LLJ) below 320 m at the suburban site were weaker than those at the urban site, and the LLJ heights and depths at the suburban site were lower than those at the urban site. The nocturnal 140 m mean vertical velocities and the variations in vertical velocity at the urban site were larger than those at the suburban site. A nocturnal breeze with a weak LLJ of ～3 m s^(-1) noticeably offset nocturnal PM transport due to southerly flow and convergence within the northern urban area of Beijing. Characteristics of the nocturnal LLJ, such as start-up time, structure, intensity, and duration, were important factors in determining the decrease in the nocturnal horizontal range and site-based low-level variations in PM.展开更多
Two novel thermal cycles based on Brayton cycle and Rankine cycle are proposed, respectively, which integrate the recovery of low-level waste heat and Liquefied Nature Gas （LNG） cold energy utilization for power gen...Two novel thermal cycles based on Brayton cycle and Rankine cycle are proposed, respectively, which integrate the recovery of low-level waste heat and Liquefied Nature Gas （LNG） cold energy utilization for power generation. Cascade utilization of energy is realized in the two thermal cycles, where low-level waste heat,low-temperature exergy and pressure exergy of LNG are utilized efficiently through the system synthesis. The simulations are carried out using the commercial Aspen Plus 10.2, and the results are analyzed. Compared with the conventional Brayton cycle and Rankine cycle, the two novel cycles bring 60.94% and 60% in exergy efficiency, respectively and 53.08% and 52.31% in thermal efficiency, respectively.展开更多
An extremely heavy rainfall event lasting from 17 to 22 July 2021 occurred in Henan Province of China, with accumulated precipitation of more than 1000 mm over a 6-day period that exceeded its mean annual precipitatio...An extremely heavy rainfall event lasting from 17 to 22 July 2021 occurred in Henan Province of China, with accumulated precipitation of more than 1000 mm over a 6-day period that exceeded its mean annual precipitation. The present study examines the roles of persistent low-level jets(LLJs) in maintaining the precipitation using surface station observations and reanalysis datasets. The LLJs triggered strong ascending motions and carried moisture mainly from the outflow of Typhoon In-fa(2021). The varying directions of the LLJs well corresponded to the meridional shifts of the rainfall. The precipitation rate reached a maximum during 20-21 July as the LLJs strengthened and expanded vertically into double LLJs, including synoptic-weather-system-related LLJs(SLLJs) at 850–700 hPa and boundary-layer jets(BLJs)at ~950 hPa. The coupling of the SLLJ and BLJ provided strong mid-and low-level convergence on 20 July, whereas the SLLJ produced mid-level divergence at its entrance that coupled with low-level convergence at the terminus of the BLJ on21 July. The formation mechanisms of the two types of LLJs are further examined. The SLLJs and the low-pressure vortex(or inverted trough) varied synchronously as a whole and were affected by the southwestward movement of the WPSH in the rainiest period. The persistent large total pressure gradient force at low levels also maintained the strength of low-level geostrophic winds, thus sustaining the BLJs on the synoptic scale. The results based on a Du-Rotunno 1D model show that the Blackadar and Holton mechanisms jointly governed the BLJ dynamics on the diurnal scale.展开更多
Low-level radio frequency(LLRF)systems stabilize the electromagnetic field in the RF cavities used for beam acceleration in particle accelerators.Reliable,accurate,and precise detection of RF amplitude and phase is pa...Low-level radio frequency(LLRF)systems stabilize the electromagnetic field in the RF cavities used for beam acceleration in particle accelerators.Reliable,accurate,and precise detection of RF amplitude and phase is particularly important to achieve high field stability for pulsed accelerators of free-electron lasers(FEL).The digital LLRF systems employ analog-to-digital converters to sample the frequency down-converted RF signal and use digital demodulation algorithms to calculate the RF amplitude and phase.Different sampling strategies and demodulation algorithms have been developed for these purposes and are introduced in this paper.This article focuses on advanced topics concerning RF detection,including accurate RF transient measurement,wideband RF detection,and RF detection with an asynchronous trigger,local oscillator,or clock.The analysis is based on the SwissFEL measurements,but the algorithms introduced are general for RF signal detection in particle accelerators.展开更多
Low-level laser therapy(LLLT) may have an effect on the pain associated with orthodontic treatment. The aim of this study was to evaluate the effect of LLLT on pain and somatosensory sensitization induced by orthodont...Low-level laser therapy(LLLT) may have an effect on the pain associated with orthodontic treatment. The aim of this study was to evaluate the effect of LLLT on pain and somatosensory sensitization induced by orthodontic treatment. Forty individuals(12–33 years old; mean ± standard deviations: 20.8 ± 5.9 years) scheduled to receive orthodontic treatment were randomly divided into a laser group(LG) or a placebo group(PG)(1:1). The LG received LLLT(810-nm gallium-aluminium-arsenic diode laser in continuous mode with the power set at 400 mW, 2 J·cm–2) at 0 h, 2 h, 24 h, 4 d, and 7 d after treatment, and the PG received inactive treatment at the same time points. In both groups, the non-treated side served as a control. A numerical rating scale(NRS) of pain, pressure pain thresholds(PPTs), cold detection thresholds(CDTs), warmth detection thresholds(WDTs), cold pain thresholds(CPTs), and heat pain thresholds(HPTs) were tested on both sides at the gingiva and canine tooth and on the hand. The data were analysed by a repeated measures analysis of variance(ANOVA). The NRS pain scores were significantly lower in the LG group(P = 0.01). The CDTs,CPTs, WDTs, HPTs, and PPTs at the gingiva and the PPTs at the canine tooth were significantly less sensitive on the treatment side of the LG compared with that of the PG(P < 0.033). The parameters tested also showed significantly less sensitivity on the nontreatment side of the LG compared to that of the PG(P < 0.043). There were no differences between the groups for any quantitative sensory testing(QST) measures of the hand. The application of LLLT appears to reduce the pain and sensitivity of the tooth and gingiva associated with orthodontic treatment and may have contralateral effects within the trigeminal system but no generalized QST effects. Thus, the present study indicated a significant analgesia effect of LLLT application during orthodontic treatment.Further clinical applications are suggested.展开更多
A statistically-based low-level cloud parameterization scheme is introduced, modified, and applied in the Flexible coupled General Circulation Model (FGCM-O). It is found that the low-level cloud scheme makes improved...A statistically-based low-level cloud parameterization scheme is introduced, modified, and applied in the Flexible coupled General Circulation Model (FGCM-O). It is found that the low-level cloud scheme makes improved simulations of low-level cloud fractions and net surface shortwave radiation fluxes in the subtropical eastern oceans off western coasts in the model. Accompanying the improvement in the net surface shortwave radiation fluxes, the simulated distribution of SSTs is more reasonably asymmetrical about the equator in the tropical eastern Pacific, which suppresses, to some extent, the development of the double ITCZ in the model. Warm SST biases in the ITCZ north of the equator are more realistically reduced, too. But the equatorial cold tongue is strengthened and extends further westward, which reduces the precipitation rate in the western equatorial Pacific but increases it in the ITCZ north of the equator in the far eastern Pacific. It is demonstrated that the low-level cloud-radiation feedback would enhance the cooperative feedback between the equatorial cold tongue and the ITCZ. Based on surface layer heat budget analyses, it is demonstrated that the reduction of SSTs is attributed to both the thermodynamic cooling process modified by the increase of cloud fractions and the oceanic dynamical cooling processes associated with the strengthened surface wind in the eastern equatorial Pacific, but it is mainly attributed to oceanic dynamical cooling processes associated with the strengthening of surface wind in the central and western equatorial Pacific.展开更多
To investigate the effect of low-level occupational benzene exposure on human peripheral blood leukocyte counts of the workers,domestic and foreign published research data on the change of human peripheral blood leuko...To investigate the effect of low-level occupational benzene exposure on human peripheral blood leukocyte counts of the workers,domestic and foreign published research data on the change of human peripheral blood leukocyte counts under low-level occupational benzene exposure from January 1990 to December 2020 were collected and analyzed.According to the literature inclusion and exclusion criteria,18 independent studies from 12 publications were selected for meta-analysis to explore the effect of low-level occupational benzene exposure on human peripheral blood leukocyte counts.The results showed that the peripheral blood leukocyte counts abnormal rates of low-level occupational benzene exposure group were higher than those of the control group,and the difference was statistically significant.Low-level occupational benzene exposure could result in a relatively higher abnormal rate of peripheral blood leukocyte counts in the exposed population,indicating that low-level occupational benzene exposure at workplaces specified by the current benzene occupational exposure limit in China would affect the peripheral blood leukocyte counts of the workers,thus benzene with concentrations under the limit in the ambient air of workplace could be still harmful to the health of the exposed workers.The results of this study could provide a scientific basis for future revision of the benzene occupational exposure limit in China,and could also be a reference for the formulation of environmental standard concerning benzene in China in the future.展开更多
Background: Patients commonly develop postoperative pain after total knee arthroplasty(TKA).Acupuncture-related techniques and low-level laser therapy could be beneficial for pain management for older individuals.Obje...Background: Patients commonly develop postoperative pain after total knee arthroplasty(TKA).Acupuncture-related techniques and low-level laser therapy could be beneficial for pain management for older individuals.Objective: To examine the effect of low-level laser acupuncture(LA) in reducing postoperative pain, painrelated interference in daily life, morphine consumption, and morphine-related side effects in older patients with knee osteoarthritis who underwent TKA.Design, setting, participants and intervention: A single-blind randomized placebo-controlled trial was conducted. Patients(N = 82) were recruited and randomly assigned via a computer-generated list to the LA group or a placebo group. The LA group received low-level laser therapy at Sanyinjiao(SP6), Taixi(KI3),Kunlun(BL60), Fengshi(GB31), Futu(ST32) and Neiguan(PC6) after TKA, while the placebo acupuncture group received the same treatment procedure without laser energy output.Main outcome measures: The primary outcome was postoperative pain intensity, and it was measured at baseline and hours 2, 6, 10, 24, 48 and 72 after TKA. The secondary outcomes, including relative pain,postoperative pain-related interference in daily life and morphine consumption, were measured at hours24, 48 and 72 after TKA.Results: Generalized estimating equations revealed significant between-group differences in pain intensity(P = 0.01), and trend differences in pain intensity for the LA group starting at hours 10 to 72(P < 0.05)and morphine consumption at hours 48 and 72(P < 0.05). The changes in pain-related interference in daily life were significant(P < 0.05) at 72 h, with the exception of the parameters for worst pain, mood,and sleep. Nausea and vomiting side effects from morphine had significant between-group differences at hours 10 and 24(P < 0.05).Conclusion: Low-level LA gradually reduced older patients’ postoperative pain intensity and morphine consumption within the first 72 h after their TKA for osteoarthritis. Low-level LA may have benefits as an adjuvant pain management technique for clinical care.Trial registration: ClinicalTrials.gov registration number NCT03995446.展开更多
Objective To gain a better understanding of gene expression changes in the brain following microwave exposure in mice. This study hopes to reveal mechanisms contributing to microwave-induced learning and memory dysfun...Objective To gain a better understanding of gene expression changes in the brain following microwave exposure in mice. This study hopes to reveal mechanisms contributing to microwave-induced learning and memory dysfunction. Methods Mice were exposed to whole body 2100 MHz microwaves with specific absorption rates (SARs) of 0.45 W/kg, 1.8 W/kg, and 3.6 W/kg for 1 hour daily for 8 weeks. Differentially expressing genes in the brains were screened using high-density oligonucleotide arrays, with genes showing more significant differences further confirmed by RT-PCR. Results The gene chip results demonstrated that 41 genes (0.45 W/kg group), 29 genes (1.8 W/kg group), and 219 genes (3.6 W/kg group) were differentially expressed. GO analysis revealed that these differentially expressed genes were primarily involved in metabolic processes, cellular metabolic processes, regulation of biological processes, macromolecular metabolic processes, biosynthetic processes, cellular protein metabolic processes, transport, developmental processes, cellular component organization, etc. KEGG pathway analysis showed that these genes are mainly involved in pathways related to ribosome, Alzheimer's disease, Parkinson's disease, long-term potentiation, Huntington's disease, and Neurotrophin signaling. Construction of a protein interaction network identified several important regulatory genes including synbindin (sbdn), Crystallin (CryaB), PPP1CA, Ywhaq, Psap, Psmb1, Pcbp2, etc., which play important roles in the processes of learning and memory. Conclusion Long-term, low-level microwave exposure may inhibit learning and memory by affecting protein and energy metabolic processes and signaling pathways relating to neurological functions or diseases.展开更多
The southwesterly low-level jet （LLJ） over southeast China in the summer of 2003 is analyzed in this study. The analysis is based on the National Centers for Environmental Prediction （NCEP） Final （FNL） operation...The southwesterly low-level jet （LLJ） over southeast China in the summer of 2003 is analyzed in this study. The analysis is based on the National Centers for Environmental Prediction （NCEP） Final （FNL） operational global analysis data on 1.0-1.0-degree grids at 6-h intervals. The major criteria for choosing the LLJ ineluded the following： a maximum wind speed equal to or greater than 12.0 m s-1, a wind direction of between 180° and 270°, and the height of wind maximum at 900-700 hPa, not confined to single pressure level. The results show that the LLJs over southeast China dominate at 850 and 800 hPa. These LLJs are closely associated with the topography of this area and tend to locate regions with large terrain gradients, including the northeastern and eastem Yunnan-Guizhou Plateau. Under the influence of mid-latitude westerly winds, the LLJs above 750 hPa move northward to the Yangtze-Huai River Basin. Com- pared to the ten-year （2000-2009） mean climate condi- tions, the LLJs in the warm season of summer 2003 were exceptionally active and strong, as reflected by the posi- tive anomalies of LLJ occurrence numbers and wind speed. In addition, the 2003 LLJs showed strong diurnal variation, especially at pressure levels below 800 hPa. The majority of the LLJs appeared between midnight and the early moming hours （before 8 a.m.）. Finally, the summary of LLJ grid numbers indicates that more than 80% of LLJs in June and July 2003 occurred within the 33-d rainy period. Thus, these LLJs are directly related to the anomalously heavy rainfall in the Yangtze-Huai River Basin.展开更多
This study examines the diversity of low-level jet(LLJ)formation and related physical processes over southern China.A total of 171 LLJ formation events with enhanced daily southwesterlies and early-morning maximum win...This study examines the diversity of low-level jet(LLJ)formation and related physical processes over southern China.A total of 171 LLJ formation events with enhanced daily southwesterlies and early-morning maximum wind speeds were observed during the mei-yu seasons of 1989–2018.The LLJs can be further categorized into four types based on the increases in the daily mean and diurnal amplitude of the low-level winds.Analysis of the synoptic-scale disturbances shows that the two types of LLJ formation(Q1 and Q4),which feature large increases of daily southerly wind components,are mainly induced by west-east dipole patterns of pressure change,in association with the enhanced southwest vortex and/or the western Pacific subtropical high(WPSH).In contrast,the other two types(Q2 and Q3),which feature relatively large increases in their daily westerly components,are related to a northwest-southeast dipole pattern of pressure change due to the mid-latitude trough and the WPSH.We further analyze the considerable variations in the diurnal thermal forcing among the LLJ formation events.The strong(weak)daytime heating of solar radiation leads to relatively large(small)increases in the diurnal amplitude of low-level winds in Q1 and Q2(Q3 and Q4)types.Therefore,different combinations of synopticscale disturbances and diurnal thermal forcings are found to account for the diversity in LLJ formation and associated differences in downstream rainfall patterns.These results help to improve our understanding and prediction of the formation of LLJs.展开更多
The uncertainty of nuclide libraries in the analysis of the gamma spectra of low-and intermediate-level radioactive waste(LILW)using existing methods produces unstable results.To address this problem,a novel spectral ...The uncertainty of nuclide libraries in the analysis of the gamma spectra of low-and intermediate-level radioactive waste(LILW)using existing methods produces unstable results.To address this problem,a novel spectral analysis method is proposed in this study.In this method,overlapping peaks are located using a continuous wavelet transform.An improved quadratic convolution method is proposed to calculate the widths of the peaks and establish a fourth-order filter model to estimate the Compton edge baseline with the overlapping peaks.Combined with the adaptive sensitive nonlinear iterative peak,this method can effectively subtracts the background.Finally,a function describing the peak shape as a filter is used to deconvolve the energy spectrum to achieve accurate qualitative and quantitative analyses of the nuclide without the aid of a nuclide library.Gamma spectrum acquisition experiments for standard point sources of Cs-137 and Eu-152,a segmented gamma scanning experiment for a 200 L standard drum,and a Monte Carlo simulation experiment for triple overlapping peaks using the closest energy of three typical LILW nuclides(Sb-125,Sb-124,and Cs-134)are conducted.The results of the experiments indicate that(1)the novel method and gamma vision(GV)with an accurate nuclide library have the same spectral analysis capability,and the peak area calculation error is less than 4%;(2)compared with the GV,the analysis results of the novel method are more stable;(3)the novel method can be applied to the activity measurement of LILW,and the error of the activity reconstruction at the equivalent radius is 2.4%;and(4)The proposed novel method can quantitatively analyze all nuclides in LILW without a nuclide library.This novel method can improve the accuracy and precision of LILW measurements,provide key technical support for the reasonable disposal of LILW,and ensure the safety of humans and the environment.展开更多
The influence of low_level noise has not been widely noticed. This paper discovered that low_level and low frequency noise(A_weighted equivalent level L eq <45 dB) causes higher probability of subjective annoyance....The influence of low_level noise has not been widely noticed. This paper discovered that low_level and low frequency noise(A_weighted equivalent level L eq <45 dB) causes higher probability of subjective annoyance. The fuzzy mathematic principle was applied to deal with the threshold level of subjective annoyance from noise in this study; there is preferable relationship between the indoor noise and noise annoyance at low frequency noise level. Study indicated at the same centered noise level, the change of annoyance probability is mainly caused by the change of the frequency spectrum characteristic of the indoor noise. Under low noise level environment, without change of the medium_low frequency noise, the slight increase of medium_high frequency noise level with the help of noise sheltering effect can significantly reduce the noise annoyance. This discovery brings a new resolution on how to improve the environmental quality of working or living places. A noise control model is given in this study according to the acoustic analysis.展开更多
基金supported by the National Natural Science Foundation of China(Nos.22076052 and 21976063)China Postdoctoral Science Foundation(No.2018M642850)the Research Funding of Wuhan Polytechnic University(No.2023RZ017).
文摘An efficient catalytic system was developed to remove various organic pollutants by simultaneously using low-level cobalt ions,calcium carbonate micro-particles and peroxymonosulfate(PMS).A simple base-induced precipitation was used to successfully loaded Co-centered reactive sites onto the surface of CaCO_(3)microparticles.Under optimal conditions at 25°C,10 mg/L methylene blue(MB)could be completely degraded within 10 min with 480μg/L Co^(2+),0.4 g/L CaCO_(3)microparticles(or 0.4 g/L Co@CaCO_(3))and 0.1 g/L PMS.The MB degradation followed the pseudo first order kinetics with a rate constant of 0.583 min^(−1),being 8.3,11.5 and 53.0 times that by using Co-OH(0.07 min^(−1)),Co^(2+)(0.044 min^(−1))and CaCO_(3)(0.011 min^(−1))as the catalyst,respectively.It was confirmed that there was a synergistic effect in the catalytic activity between Co species and the CaCO_(3)particles but the major contributor was the highly dispersed Co species.When Co^(2+)-containing simulated electroplating wastewater was used as the Co^(2+)source,not only the added MB was also completely degraded within 5 min in this catalytic system,but also the coexisting heavy metal ions were substantially removed.The presently developed method was applied to simultaneously treat organic wastewater and heavy metals wastewater.The present method was also successfully used to efficiently degrade other organic pollutants including bisphenol A,sulfamethoxazole,rhodamine B,tetrabromobisphenol A,ofloxacin and benzoic acid.A catalytic mechanism was proposed for the PMS activation by Co@CaCO_(3).The surface of CaCO_(3)particles favors the adsorption of Co^(2+).More importantly,the surface of CaCO_(3)particles provides plentiful surface-OH and-CO_(3)^(2+),and these surface groups complex with Co^(2+)to producemore catalytically active species such as surface[CoOH]^(−),resulting in rapid Co^(2+)/Co^(3+)cycling and electron transfer.These interactions cause the observed synergistic effect between Co species and CaCO_(3)particles in PMS activation.Due to good cycle stability,strong anti-interference ability and wide universality,the new method will have broad application prospects.
基金support from the European Union’s Horizon 2020 research and innovation framework program under Grant No.101003590(PolarRES)funding from the Indian Institute of Technology Kharagpur and the Ministry of Education,Government of India。
文摘We show that low-level jets(LLJs)occurred in 11 out of 22 radiosonde profiles in late austral summer over the coastal region of the Amundsen Sea Embayment,with ten of the LLJs directed offshore.The LLJs had core speeds from 9 to 32 m s^(-1),jet core heights from 80 to 800 m,and were associated with strong,low-level temperature inversions.Seven of the observed offshore LLJs were reasonably simulated by the polar-optimized Weather Research and Forecasting(Polar WRF)model,with output from the model subsequently used to elucidate their generation mechanisms.This study shows that one of the offshore LLJs simulated by the Polar WRF was caused by katabatic winds,while the remaining six were caused by the enhancement of katabatic winds by synoptic forcing in response to a low-pressure system over the Bellingshausen Sea,i.e.,the offshore wind component associated with this system plays a crucial role in the enhancement of the katabatic LLJ.Examination of the Polar WRF output further shows that the LLJs extended over large areas of the Amundsen Sea Embayment,resulting in substantially enhanced near-surface wind speeds over both the Thwaites and Pine Island ice shelves,as well as the open ocean over the continental shelf.The wind-driven forcing associated with the LLJs could perhaps have important impacts on the redistribution of snow over the ice shelves significantly,as well as to affecting sea-ice and ocean circulation variability,including the transport of relatively warm water over the continental shelf to the ice shelf cavities and extension basal melting.
基金supported by the National Natural Science Foundation of China(Grant Nos.42122033,42205005,42075006,and 42475002)the Basic Research and Operation Funding of the Chinese Academy of Meteorological Sciences(Grant No.2022Y009)+1 种基金the Key Innovation Team of China Meteorological Administration(CMA2023ZD08)the Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(Grant No.316323005).
文摘This study examines low-level jets(LLJs)across Northeastern China during both warm(June-September)and cold seasons(December-March)from 1957 to 2021,using fifth generation of the European Centre for Medium-Range Weather Forecasts reanalysis data with 25-km resolution.LLJs manifest in two prominent regions,one along the leeward flank of the Da Hinggan Ling Mountains in the cold season and another at the center of Northeastern China in the warm season.The intricate interplay between ambient circulation and terrain shapes LLJ distribution,altitudes,wind directions,diurnal cycles,and seasonal diversities.During the warm season,prevailing southwesterly LLJs are found at 925 hPa,while the cold season features stronger and more frequent northwesterly LLJs at 875 hPa.Analysis of the diurnal patterns reveals distinctive behaviors of LLJs in the cold and warm seasons.During the warm season,the single peak in LLJ occurrence emerges around midnight;conversely,in the cold season,LLJs are most frequent shortly before midnight,with an additional sub-peak in the morning.A momentum budget analysis establishes mechanisms underlying these two distinct diurnal variations.In both seasons,the diurnal variation of LLJs is predominately driven by an inertial oscillation and mountain-valley circulations.However,the sub-peak observed in the cold-season morning arises from the thermodynamic and dynamic interaction between the low-level atmosphere and complex terrain.
基金supported by the National Natural Science Foundation of China(grant no.82273631)the Science and Technology Planning Project of Shenzhen City,Guangdong Province,China(grant no.JCYJ20220531094410024)the Shenzhen Medical Key Discipline Construction Fund,Guangdong Province,China(grant no.SZXK065).
文摘Objective Evidence that long-term exposure to ambient air pollution increases mortality among older adults,particularly those residing in low-level air pollution locations,remains scarce.This study investigated the potential links between long-term low-level air pollution exposure and mortality among Chinese older adults.Methods A population-based study with 317,464 individuals aged≥65 years was conducted in Shenzhen,China during 2018 and 2020.Logistic regression models were used to analyze the associations between long-term exposure to air pollution and all-cause mortality,as the primary outcome,as well as non-accidental,cancer and cardiovascular mortality.Results Significant associations of PM1,PM_(2.5),PM_(10),SO_(2),CO,and O3 exposures with a higher risk of all-cause mortality were found.Adjusted odds ratio(OR)for each 1μg/m^(3) increment was 1.49[95%confidence interval(CI):1.46,1.53]for PM1,1.30(1.27,1.32)for PM_(2.5),1.05(1.04,1.06)for PM_(10),5.84(5.39,6.32)for SO_(2),1.04(1.04,1.05)for CO,and 1.02(1.00,1.03)for O3,respectively.Long-term PM1,PM_(2.5),PM_(10),SO_(2),and CO exposures also elevated the risks of non-accidental,cancer and cardiovascular mortality.Conclusion Long-term low-level air pollution exposure was associated with an increased mortality risk among Chinese older adults.
基金supported by the Taishan Scholars Programs of Shandong Province(No.tsqn201909165)the Global Change and Air-Sea Interaction Program(Nos.GASI-04-QYQH-03,GASI-01-WIND-STwin)the National Natural Science Foundation of China(Nos.41876028,42349910).
文摘In contrast to the Pacific and Atlantic Oceans,the Indian Ocean has lacked in-situ observations of wind profiles over open sea areas for decades.In 2021,a shipborne coherent Doppler lidar(CDL)was used to observe in-situ wind profiles in the eastern tropical Indian Ocean.This equipment successfully captured low-level jets(LLJs)in the region,and their characteristics were thoroughly analyzed.Results reveal that the observed wind speed of LLJs in the eastern Indian Ocean ranges from 6 m s^(-1) to 10 m s^(-1) during the boreal winter and spring seasons,showing a height range of 0.6 to 1 km and two peak times at 0800 and 2000 UTC.This wind shear is weaker than that in land or offshore areas,ranging from 0 s^(-1) to 0.006 s^(-1).Moreover,the accuracy of the CDL data is compared to that of ERA5 data in the study area.The results indicate that the zonal wind from ERA5 data significantly deviated from the CDL measurement data,and the overall ERA5 data are substantially weaker than the in-situ observations.Notably,ERA5 underestimates northwestward LLJs.
文摘Chronic hepatitis B virus(HBV)infection(CHB)is a public health concern worldwide.Current therapies utilizing nucleos(t)ide analogs(NA)have not resulted in a complete cure for CHB.Furthermore,patients on long-term NA treatment often develop low-level viremia(LLV).Persistent LLV,in addition to causing the progression of liver disease or hepatocellular carcinoma,may shed light on the current plight of NA therapy.Here,we review the literature on LLV,NA treatment,and various doses of entecavir to find a strategy for improving the efficacy of this antiviral agent.For LLV patients,three therapeutic options are available,switching to another antiviral monotherapy,interferon-αswitching therapy,and continuing monotherapy.In real-world clinical practice,entecavir overdose has been used in antiviral therapy for CHB patients with NA refractory and persistent LLV,which encouraged us to conduct further in-depth literature survey on dosage and duration related entecavir studies.The studies of pharmacodynamics and pharmacokinetics show that entecavir has the maximal selected index for safety,and has great potential in inhibiting HBV replication,in all of the NAs.In the particular section of the drug approval package published by the United States Food and Drug Administration,entecavir doses 2.5-20 mg/d do not increase adverse events,and entecavir doses higher than 1.0 mg/d might improve the antiviral efficacy.The literature survey led us to two suggestions:(1)Increasing entecavir dose to 1.0 mg/d for the treatment of NA naïve patients with HBV DNA>2×106 IU/mL is feasible and would provide better prognosis;and(2)Further research is needed to assess the long-term toxic effects of higher entecavir doses(2.5 and 5.0 mg/d),which may prove beneficial in treating patients with prior NA treatment,partial virological response,or LLV state.
基金supported by the Special Foundation of the China Meteorological Administration (Grant No.GYHY201506006)supported by the National Science Foundation of China (Grant Nos.41405100,41322032 and 41275031)
文摘The diurnal variation of precipitation over the Dabie Mountains(DBM) in eastern China during the 2013 mei-yu season is investigated with forecasts of a regional convection-permitting model. Simulated precipitation is verified against surface rain-gauge observations. The observed morning precipitation peak on the windward(relative to the prevailing synoptic-scale wind) side of the DBM is reproduced with good spatial and temporal accuracy. The interaction between the DBM and a nocturnal boundary layer low-level jet(BLJ) due to the inertial oscillation mechanism is shown to be responsible for this precipitation peak. The BLJ is aligned with the lower-level southwesterly synoptic-scale flow that carries abundant moisture.The BLJ core is established at around 0200 LST upwind of the mountains. It moves towards the DBM and reaches maximum intensity at about 70 km ahead of the mountains. When the BLJ impinges upon the windward side of the DBM in the early morning, mechanical lifting of moist air leads to condensation and subsequent precipitation.
基金supported by the National Key R&D Program of China (Grant No.2017YFC0209801)the National Natural Science Foundation of China (Grant Nos.41505091,91544221,41675137,41575124 and 41505116)
文摘Three-month wind profiles, 260 m PM_1 concentrations [i.e., particulate matter(PM) with an aerodynamic diameter ≤1μm], and carrier-to-noise ratio data at two Beijing sites 55 km apart(urban and suburban) were collected to analyze the characteristics of low-level nocturnal wind and PM in autumn and winter. Three mountain-plain wind events with wind shear were selected for analysis. The measurements indicated that the maximum wind speeds of the northerly weak low-level jet(LLJ) below 320 m at the suburban site were weaker than those at the urban site, and the LLJ heights and depths at the suburban site were lower than those at the urban site. The nocturnal 140 m mean vertical velocities and the variations in vertical velocity at the urban site were larger than those at the suburban site. A nocturnal breeze with a weak LLJ of ～3 m s^(-1) noticeably offset nocturnal PM transport due to southerly flow and convergence within the northern urban area of Beijing. Characteristics of the nocturnal LLJ, such as start-up time, structure, intensity, and duration, were important factors in determining the decrease in the nocturnal horizontal range and site-based low-level variations in PM.
基金the Science and Technology Foundation of Shaanxi Province (No.2002K08-G9).
文摘Two novel thermal cycles based on Brayton cycle and Rankine cycle are proposed, respectively, which integrate the recovery of low-level waste heat and Liquefied Nature Gas （LNG） cold energy utilization for power generation. Cascade utilization of energy is realized in the two thermal cycles, where low-level waste heat,low-temperature exergy and pressure exergy of LNG are utilized efficiently through the system synthesis. The simulations are carried out using the commercial Aspen Plus 10.2, and the results are analyzed. Compared with the conventional Brayton cycle and Rankine cycle, the two novel cycles bring 60.94% and 60% in exergy efficiency, respectively and 53.08% and 52.31% in thermal efficiency, respectively.
基金supported by Guangdong Major Project of Basic and Applied Basic Research(2020B0301030004)the National Natural Science Foundation of China(Grant Nos.42122033,41875055,and 42075006)Guangzhou Science and Technology Plan Projects(202002030346 and 202002030196).
文摘An extremely heavy rainfall event lasting from 17 to 22 July 2021 occurred in Henan Province of China, with accumulated precipitation of more than 1000 mm over a 6-day period that exceeded its mean annual precipitation. The present study examines the roles of persistent low-level jets(LLJs) in maintaining the precipitation using surface station observations and reanalysis datasets. The LLJs triggered strong ascending motions and carried moisture mainly from the outflow of Typhoon In-fa(2021). The varying directions of the LLJs well corresponded to the meridional shifts of the rainfall. The precipitation rate reached a maximum during 20-21 July as the LLJs strengthened and expanded vertically into double LLJs, including synoptic-weather-system-related LLJs(SLLJs) at 850–700 hPa and boundary-layer jets(BLJs)at ~950 hPa. The coupling of the SLLJ and BLJ provided strong mid-and low-level convergence on 20 July, whereas the SLLJ produced mid-level divergence at its entrance that coupled with low-level convergence at the terminus of the BLJ on21 July. The formation mechanisms of the two types of LLJs are further examined. The SLLJs and the low-pressure vortex(or inverted trough) varied synchronously as a whole and were affected by the southwestward movement of the WPSH in the rainiest period. The persistent large total pressure gradient force at low levels also maintained the strength of low-level geostrophic winds, thus sustaining the BLJs on the synoptic scale. The results based on a Du-Rotunno 1D model show that the Blackadar and Holton mechanisms jointly governed the BLJ dynamics on the diurnal scale.
文摘Low-level radio frequency(LLRF)systems stabilize the electromagnetic field in the RF cavities used for beam acceleration in particle accelerators.Reliable,accurate,and precise detection of RF amplitude and phase is particularly important to achieve high field stability for pulsed accelerators of free-electron lasers(FEL).The digital LLRF systems employ analog-to-digital converters to sample the frequency down-converted RF signal and use digital demodulation algorithms to calculate the RF amplitude and phase.Different sampling strategies and demodulation algorithms have been developed for these purposes and are introduced in this paper.This article focuses on advanced topics concerning RF detection,including accurate RF transient measurement,wideband RF detection,and RF detection with an asynchronous trigger,local oscillator,or clock.The analysis is based on the SwissFEL measurements,but the algorithms introduced are general for RF signal detection in particle accelerators.
基金funded by the Priority Academic Program Development of Jiangsu Higher Education Institution(Grant No.2014-37)the Jiangsu Provincial Health and Family Planning Commission(No.H201535)Orofacial Pain and TMD Research Unit,Institute of Stomatology,Affiliated Hospital of Stomatology,Nanjing Medical University,for their support
文摘Low-level laser therapy(LLLT) may have an effect on the pain associated with orthodontic treatment. The aim of this study was to evaluate the effect of LLLT on pain and somatosensory sensitization induced by orthodontic treatment. Forty individuals(12–33 years old; mean ± standard deviations: 20.8 ± 5.9 years) scheduled to receive orthodontic treatment were randomly divided into a laser group(LG) or a placebo group(PG)(1:1). The LG received LLLT(810-nm gallium-aluminium-arsenic diode laser in continuous mode with the power set at 400 mW, 2 J·cm–2) at 0 h, 2 h, 24 h, 4 d, and 7 d after treatment, and the PG received inactive treatment at the same time points. In both groups, the non-treated side served as a control. A numerical rating scale(NRS) of pain, pressure pain thresholds(PPTs), cold detection thresholds(CDTs), warmth detection thresholds(WDTs), cold pain thresholds(CPTs), and heat pain thresholds(HPTs) were tested on both sides at the gingiva and canine tooth and on the hand. The data were analysed by a repeated measures analysis of variance(ANOVA). The NRS pain scores were significantly lower in the LG group(P = 0.01). The CDTs,CPTs, WDTs, HPTs, and PPTs at the gingiva and the PPTs at the canine tooth were significantly less sensitive on the treatment side of the LG compared with that of the PG(P < 0.033). The parameters tested also showed significantly less sensitivity on the nontreatment side of the LG compared to that of the PG(P < 0.043). There were no differences between the groups for any quantitative sensory testing(QST) measures of the hand. The application of LLLT appears to reduce the pain and sensitivity of the tooth and gingiva associated with orthodontic treatment and may have contralateral effects within the trigeminal system but no generalized QST effects. Thus, the present study indicated a significant analgesia effect of LLLT application during orthodontic treatment.Further clinical applications are suggested.
基金This study was jointly supported by the National Science Foundation of China under Grant No.s40233031 and 40221503the National Key Basic Research Project under Grant No.G200078502.
文摘A statistically-based low-level cloud parameterization scheme is introduced, modified, and applied in the Flexible coupled General Circulation Model (FGCM-O). It is found that the low-level cloud scheme makes improved simulations of low-level cloud fractions and net surface shortwave radiation fluxes in the subtropical eastern oceans off western coasts in the model. Accompanying the improvement in the net surface shortwave radiation fluxes, the simulated distribution of SSTs is more reasonably asymmetrical about the equator in the tropical eastern Pacific, which suppresses, to some extent, the development of the double ITCZ in the model. Warm SST biases in the ITCZ north of the equator are more realistically reduced, too. But the equatorial cold tongue is strengthened and extends further westward, which reduces the precipitation rate in the western equatorial Pacific but increases it in the ITCZ north of the equator in the far eastern Pacific. It is demonstrated that the low-level cloud-radiation feedback would enhance the cooperative feedback between the equatorial cold tongue and the ITCZ. Based on surface layer heat budget analyses, it is demonstrated that the reduction of SSTs is attributed to both the thermodynamic cooling process modified by the increase of cloud fractions and the oceanic dynamical cooling processes associated with the strengthened surface wind in the eastern equatorial Pacific, but it is mainly attributed to oceanic dynamical cooling processes associated with the strengthening of surface wind in the central and western equatorial Pacific.
基金financially supported by the programs from the Beijing Municipal Science and Technology Commission(No.Z181100005418015)the Special Research Project for the National Environmental Protection Public Welfare Industry of China(No.201009032)the Finance Allocation Project of Ministry of Ecology and Environment of China(No.2110105)
文摘To investigate the effect of low-level occupational benzene exposure on human peripheral blood leukocyte counts of the workers,domestic and foreign published research data on the change of human peripheral blood leukocyte counts under low-level occupational benzene exposure from January 1990 to December 2020 were collected and analyzed.According to the literature inclusion and exclusion criteria,18 independent studies from 12 publications were selected for meta-analysis to explore the effect of low-level occupational benzene exposure on human peripheral blood leukocyte counts.The results showed that the peripheral blood leukocyte counts abnormal rates of low-level occupational benzene exposure group were higher than those of the control group,and the difference was statistically significant.Low-level occupational benzene exposure could result in a relatively higher abnormal rate of peripheral blood leukocyte counts in the exposed population,indicating that low-level occupational benzene exposure at workplaces specified by the current benzene occupational exposure limit in China would affect the peripheral blood leukocyte counts of the workers,thus benzene with concentrations under the limit in the ambient air of workplace could be still harmful to the health of the exposed workers.The results of this study could provide a scientific basis for future revision of the benzene occupational exposure limit in China,and could also be a reference for the formulation of environmental standard concerning benzene in China in the future.
文摘Background: Patients commonly develop postoperative pain after total knee arthroplasty(TKA).Acupuncture-related techniques and low-level laser therapy could be beneficial for pain management for older individuals.Objective: To examine the effect of low-level laser acupuncture(LA) in reducing postoperative pain, painrelated interference in daily life, morphine consumption, and morphine-related side effects in older patients with knee osteoarthritis who underwent TKA.Design, setting, participants and intervention: A single-blind randomized placebo-controlled trial was conducted. Patients(N = 82) were recruited and randomly assigned via a computer-generated list to the LA group or a placebo group. The LA group received low-level laser therapy at Sanyinjiao(SP6), Taixi(KI3),Kunlun(BL60), Fengshi(GB31), Futu(ST32) and Neiguan(PC6) after TKA, while the placebo acupuncture group received the same treatment procedure without laser energy output.Main outcome measures: The primary outcome was postoperative pain intensity, and it was measured at baseline and hours 2, 6, 10, 24, 48 and 72 after TKA. The secondary outcomes, including relative pain,postoperative pain-related interference in daily life and morphine consumption, were measured at hours24, 48 and 72 after TKA.Results: Generalized estimating equations revealed significant between-group differences in pain intensity(P = 0.01), and trend differences in pain intensity for the LA group starting at hours 10 to 72(P < 0.05)and morphine consumption at hours 48 and 72(P < 0.05). The changes in pain-related interference in daily life were significant(P < 0.05) at 72 h, with the exception of the parameters for worst pain, mood,and sleep. Nausea and vomiting side effects from morphine had significant between-group differences at hours 10 and 24(P < 0.05).Conclusion: Low-level LA gradually reduced older patients’ postoperative pain intensity and morphine consumption within the first 72 h after their TKA for osteoarthritis. Low-level LA may have benefits as an adjuvant pain management technique for clinical care.Trial registration: ClinicalTrials.gov registration number NCT03995446.
基金supported by the Foundation of Astronaut Research and Training Center of China(No.SN 02-3)
文摘Objective To gain a better understanding of gene expression changes in the brain following microwave exposure in mice. This study hopes to reveal mechanisms contributing to microwave-induced learning and memory dysfunction. Methods Mice were exposed to whole body 2100 MHz microwaves with specific absorption rates (SARs) of 0.45 W/kg, 1.8 W/kg, and 3.6 W/kg for 1 hour daily for 8 weeks. Differentially expressing genes in the brains were screened using high-density oligonucleotide arrays, with genes showing more significant differences further confirmed by RT-PCR. Results The gene chip results demonstrated that 41 genes (0.45 W/kg group), 29 genes (1.8 W/kg group), and 219 genes (3.6 W/kg group) were differentially expressed. GO analysis revealed that these differentially expressed genes were primarily involved in metabolic processes, cellular metabolic processes, regulation of biological processes, macromolecular metabolic processes, biosynthetic processes, cellular protein metabolic processes, transport, developmental processes, cellular component organization, etc. KEGG pathway analysis showed that these genes are mainly involved in pathways related to ribosome, Alzheimer's disease, Parkinson's disease, long-term potentiation, Huntington's disease, and Neurotrophin signaling. Construction of a protein interaction network identified several important regulatory genes including synbindin (sbdn), Crystallin (CryaB), PPP1CA, Ywhaq, Psap, Psmb1, Pcbp2, etc., which play important roles in the processes of learning and memory. Conclusion Long-term, low-level microwave exposure may inhibit learning and memory by affecting protein and energy metabolic processes and signaling pathways relating to neurological functions or diseases.
基金supported by the National Natural Science Foundation of China (Grant No. 40905049)the National High Technology Research and Development Program of China (863 Program, Grant No. 2010AA012304)+1 种基金the China Mete-orological Administration for the R&D Special Fund for Public Welfare Industry (Meteorology) (Grant No. GYHY200906020)the State Key Laboratory of Numerical Modelling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG) State Key Laboratory special fund
文摘The southwesterly low-level jet （LLJ） over southeast China in the summer of 2003 is analyzed in this study. The analysis is based on the National Centers for Environmental Prediction （NCEP） Final （FNL） operational global analysis data on 1.0-1.0-degree grids at 6-h intervals. The major criteria for choosing the LLJ ineluded the following： a maximum wind speed equal to or greater than 12.0 m s-1, a wind direction of between 180° and 270°, and the height of wind maximum at 900-700 hPa, not confined to single pressure level. The results show that the LLJs over southeast China dominate at 850 and 800 hPa. These LLJs are closely associated with the topography of this area and tend to locate regions with large terrain gradients, including the northeastern and eastem Yunnan-Guizhou Plateau. Under the influence of mid-latitude westerly winds, the LLJs above 750 hPa move northward to the Yangtze-Huai River Basin. Com- pared to the ten-year （2000-2009） mean climate condi- tions, the LLJs in the warm season of summer 2003 were exceptionally active and strong, as reflected by the posi- tive anomalies of LLJ occurrence numbers and wind speed. In addition, the 2003 LLJs showed strong diurnal variation, especially at pressure levels below 800 hPa. The majority of the LLJs appeared between midnight and the early moming hours （before 8 a.m.）. Finally, the summary of LLJ grid numbers indicates that more than 80% of LLJs in June and July 2003 occurred within the 33-d rainy period. Thus, these LLJs are directly related to the anomalously heavy rainfall in the Yangtze-Huai River Basin.
基金supported by the Guangdong Major Project of Basic and Applied Basic Research(2020B0301030004)the National Natural Science Foundation of China(Grant Nos.42275002,41875055,and 42122033).
文摘This study examines the diversity of low-level jet(LLJ)formation and related physical processes over southern China.A total of 171 LLJ formation events with enhanced daily southwesterlies and early-morning maximum wind speeds were observed during the mei-yu seasons of 1989–2018.The LLJs can be further categorized into four types based on the increases in the daily mean and diurnal amplitude of the low-level winds.Analysis of the synoptic-scale disturbances shows that the two types of LLJ formation(Q1 and Q4),which feature large increases of daily southerly wind components,are mainly induced by west-east dipole patterns of pressure change,in association with the enhanced southwest vortex and/or the western Pacific subtropical high(WPSH).In contrast,the other two types(Q2 and Q3),which feature relatively large increases in their daily westerly components,are related to a northwest-southeast dipole pattern of pressure change due to the mid-latitude trough and the WPSH.We further analyze the considerable variations in the diurnal thermal forcing among the LLJ formation events.The strong(weak)daytime heating of solar radiation leads to relatively large(small)increases in the diurnal amplitude of low-level winds in Q1 and Q2(Q3 and Q4)types.Therefore,different combinations of synopticscale disturbances and diurnal thermal forcings are found to account for the diversity in LLJ formation and associated differences in downstream rainfall patterns.These results help to improve our understanding and prediction of the formation of LLJs.
基金supported by the National Natural Science Foundation of China(Nos.12205190,11805121)the Science and Technology Commission of Shanghai Municipality(No.21ZR1435400).
文摘The uncertainty of nuclide libraries in the analysis of the gamma spectra of low-and intermediate-level radioactive waste(LILW)using existing methods produces unstable results.To address this problem,a novel spectral analysis method is proposed in this study.In this method,overlapping peaks are located using a continuous wavelet transform.An improved quadratic convolution method is proposed to calculate the widths of the peaks and establish a fourth-order filter model to estimate the Compton edge baseline with the overlapping peaks.Combined with the adaptive sensitive nonlinear iterative peak,this method can effectively subtracts the background.Finally,a function describing the peak shape as a filter is used to deconvolve the energy spectrum to achieve accurate qualitative and quantitative analyses of the nuclide without the aid of a nuclide library.Gamma spectrum acquisition experiments for standard point sources of Cs-137 and Eu-152,a segmented gamma scanning experiment for a 200 L standard drum,and a Monte Carlo simulation experiment for triple overlapping peaks using the closest energy of three typical LILW nuclides(Sb-125,Sb-124,and Cs-134)are conducted.The results of the experiments indicate that(1)the novel method and gamma vision(GV)with an accurate nuclide library have the same spectral analysis capability,and the peak area calculation error is less than 4%;(2)compared with the GV,the analysis results of the novel method are more stable;(3)the novel method can be applied to the activity measurement of LILW,and the error of the activity reconstruction at the equivalent radius is 2.4%;and(4)The proposed novel method can quantitatively analyze all nuclides in LILW without a nuclide library.This novel method can improve the accuracy and precision of LILW measurements,provide key technical support for the reasonable disposal of LILW,and ensure the safety of humans and the environment.
文摘The influence of low_level noise has not been widely noticed. This paper discovered that low_level and low frequency noise(A_weighted equivalent level L eq <45 dB) causes higher probability of subjective annoyance. The fuzzy mathematic principle was applied to deal with the threshold level of subjective annoyance from noise in this study; there is preferable relationship between the indoor noise and noise annoyance at low frequency noise level. Study indicated at the same centered noise level, the change of annoyance probability is mainly caused by the change of the frequency spectrum characteristic of the indoor noise. Under low noise level environment, without change of the medium_low frequency noise, the slight increase of medium_high frequency noise level with the help of noise sheltering effect can significantly reduce the noise annoyance. This discovery brings a new resolution on how to improve the environmental quality of working or living places. A noise control model is given in this study according to the acoustic analysis.
