Longchang Industry Co.,,Ltd.of petroleum pipeline is one.of the standardized largeshare-system enterprises earliest organized and es-talblished in the onshore petroleum trade in China.It is the first to breakthrough t...Longchang Industry Co.,,Ltd.of petroleum pipeline is one.of the standardized largeshare-system enterprises earliest organized and es-talblished in the onshore petroleum trade in China.It is the first to breakthrough the usual practice of drawing a dividend in each fiscal year.It implement-ed to draw dividend semi-annually in March of this year,and every shareholder received a payback of 10%.In the late year,16 enterprises were estab-lished through the modes of whole-funded,joint-funded and shared-in at home and abroad,among them there being four China-Foreign jointly funded enterprises attracting foreign funds of 3 million US dollars,and eight enterprises with high and new technologies were set up in Langfang Development Zone so that the Longchang Industry Park was founded.Some enterprises have been successively put into operation,and have attained obvious eco-nomic benefit.展开更多
目的:观察癃畅颗粒对前列腺增生细胞增殖和凋亡及相关因子的影响。方法:将雄性Wistar大鼠100只,严格遵循随机分组的原则随机分为正常组、模型组、癃畅颗粒高、中、低剂量组,各20只。模型组、癃畅颗粒高、中、低剂量组给予前列腺增生模...目的:观察癃畅颗粒对前列腺增生细胞增殖和凋亡及相关因子的影响。方法:将雄性Wistar大鼠100只,严格遵循随机分组的原则随机分为正常组、模型组、癃畅颗粒高、中、低剂量组,各20只。模型组、癃畅颗粒高、中、低剂量组给予前列腺增生模型复制。正常组:普通饲养,按1 m L/100 g体重给予生理盐水灌胃,日1次,连续30 d;模型组从去势第8天起,按1 m L/100 g体重给予生理盐水灌胃,日1次,连续30 d;癃畅颗粒低、中、高剂量组:从去势第8天起,按1 m L/100 g体重分别给予低(100 mg/m L)、中(200 mg/m L)、高浓度(300 mg/m L)灌胃,日1次,连续30 d。观察前列腺组织前列腺湿重和前列腺指数、前列腺细胞增殖指数和凋亡指数、VEGF、IGF-1 m RNA、Bcl-2和Bax表达变化。结果:与正常组比较,模型组和癃畅颗粒高、中、低剂量组前列腺湿重和前列腺指数明显升高,有统计学意义(P<0.05);与模型组比较,癃畅颗粒中、高剂量组大鼠的前列腺湿重和前列腺指数显著下降,有统计学意义(P<0.05)。与正常组比较,模型组大鼠和癃畅颗粒高、中、低剂量组前列腺增生细胞的凋亡指数明显升高,有统计学意义(P<0.05),而增殖指数没有显著性差异(P>0.05);与模型组比较,癃畅颗粒高、中、低剂量组大鼠前列腺增生细胞的凋亡指数明显升高,有统计学意义(P<0.05),而增殖指数没有显著性差异(P>0.05),与正常组大鼠前列腺组织中上皮细胞层Bcl-2蛋白阳性表达比较,模型组和癃畅颗粒高、中、低剂量组,有统计学意义(P<0.05),模型组表达最强,高剂量组最弱,与正常组接近,模型组和癃畅颗粒高、中、低剂量组Bcl-2蛋白阳性表达比较,有统计学意义(P<0.05)。与正常组上皮细胞层Bax蛋白阳性表达比较,模型组和癃畅颗粒低剂量组,有统计学意义(P<0.05),与模型组上皮细胞层Bax蛋白阳性表达比较,癃畅颗粒高、中剂量组,有统计学意义(P<0.05)。与正常组VEGF表达相比,模型组和癃畅颗粒高、中、低剂量组升高最为显著,有统计学意义(P<0.05);与模型组相比,癃畅颗粒高、中、低剂量VEGF表达降低,有统计学意义(P<0.05)。与正常组IGF-1 m RNA表达相比,模型组和癃畅颗粒高、中、低剂量组升高最为显著,有统计学意义(P<0.05);与模型组相比,癃畅颗粒高、中剂量IGF-1 m RNA表达降低,有统计学意义(P<0.05)。结论:癃畅颗粒可以有效下降前列腺湿重和前列腺指数,降低VEGF、IGF-1m RNA、Bcl-2和提高Bax表达,促进前列腺细胞凋亡。展开更多
文摘Longchang Industry Co.,,Ltd.of petroleum pipeline is one.of the standardized largeshare-system enterprises earliest organized and es-talblished in the onshore petroleum trade in China.It is the first to breakthrough the usual practice of drawing a dividend in each fiscal year.It implement-ed to draw dividend semi-annually in March of this year,and every shareholder received a payback of 10%.In the late year,16 enterprises were estab-lished through the modes of whole-funded,joint-funded and shared-in at home and abroad,among them there being four China-Foreign jointly funded enterprises attracting foreign funds of 3 million US dollars,and eight enterprises with high and new technologies were set up in Langfang Development Zone so that the Longchang Industry Park was founded.Some enterprises have been successively put into operation,and have attained obvious eco-nomic benefit.
文摘目的:观察癃畅颗粒对前列腺增生细胞增殖和凋亡及相关因子的影响。方法:将雄性Wistar大鼠100只,严格遵循随机分组的原则随机分为正常组、模型组、癃畅颗粒高、中、低剂量组,各20只。模型组、癃畅颗粒高、中、低剂量组给予前列腺增生模型复制。正常组:普通饲养,按1 m L/100 g体重给予生理盐水灌胃,日1次,连续30 d;模型组从去势第8天起,按1 m L/100 g体重给予生理盐水灌胃,日1次,连续30 d;癃畅颗粒低、中、高剂量组:从去势第8天起,按1 m L/100 g体重分别给予低(100 mg/m L)、中(200 mg/m L)、高浓度(300 mg/m L)灌胃,日1次,连续30 d。观察前列腺组织前列腺湿重和前列腺指数、前列腺细胞增殖指数和凋亡指数、VEGF、IGF-1 m RNA、Bcl-2和Bax表达变化。结果:与正常组比较,模型组和癃畅颗粒高、中、低剂量组前列腺湿重和前列腺指数明显升高,有统计学意义(P<0.05);与模型组比较,癃畅颗粒中、高剂量组大鼠的前列腺湿重和前列腺指数显著下降,有统计学意义(P<0.05)。与正常组比较,模型组大鼠和癃畅颗粒高、中、低剂量组前列腺增生细胞的凋亡指数明显升高,有统计学意义(P<0.05),而增殖指数没有显著性差异(P>0.05);与模型组比较,癃畅颗粒高、中、低剂量组大鼠前列腺增生细胞的凋亡指数明显升高,有统计学意义(P<0.05),而增殖指数没有显著性差异(P>0.05),与正常组大鼠前列腺组织中上皮细胞层Bcl-2蛋白阳性表达比较,模型组和癃畅颗粒高、中、低剂量组,有统计学意义(P<0.05),模型组表达最强,高剂量组最弱,与正常组接近,模型组和癃畅颗粒高、中、低剂量组Bcl-2蛋白阳性表达比较,有统计学意义(P<0.05)。与正常组上皮细胞层Bax蛋白阳性表达比较,模型组和癃畅颗粒低剂量组,有统计学意义(P<0.05),与模型组上皮细胞层Bax蛋白阳性表达比较,癃畅颗粒高、中剂量组,有统计学意义(P<0.05)。与正常组VEGF表达相比,模型组和癃畅颗粒高、中、低剂量组升高最为显著,有统计学意义(P<0.05);与模型组相比,癃畅颗粒高、中、低剂量VEGF表达降低,有统计学意义(P<0.05)。与正常组IGF-1 m RNA表达相比,模型组和癃畅颗粒高、中、低剂量组升高最为显著,有统计学意义(P<0.05);与模型组相比,癃畅颗粒高、中剂量IGF-1 m RNA表达降低,有统计学意义(P<0.05)。结论:癃畅颗粒可以有效下降前列腺湿重和前列腺指数,降低VEGF、IGF-1m RNA、Bcl-2和提高Bax表达,促进前列腺细胞凋亡。
