Objective:After percutaneous kyphoplasty(PKP),patients with pathological vertebral fractures of thoracolumbar metastases often have Qi and blood deficiency syndrome and hidden blood loss,resulting in postoperative deb...Objective:After percutaneous kyphoplasty(PKP),patients with pathological vertebral fractures of thoracolumbar metastases often have Qi and blood deficiency syndrome and hidden blood loss,resulting in postoperative debilitation syndrome.This study aimed to evaluate the clinical efficacy and mechanism of Shenqi Hexue Decoction on early postoperative recovery of such patients.Methods:36 Patients were randomly divided into an experimental group(Shenqi Hexue Decoction+conventional treatment)and a control group(conventional treatment).The changes of hemoglobin(HB),Karnofsky functional status(KPS)score,and TCM syndrome score on the 1st,4th,and 7th day after operation were observed.Results:The HB value of the experimental group was significantly higher than that of the control group on the 4th and 7th days after operation(p<0.01),and the maximum decline value of HB decreased by 42.1%(p<0.001);The improvement rate of KPS score in the experimental group was 94.4%on the 7th day after operation,which was significantly better than 66.7%in the control group(p<0.05).The total effective rate of TCM syndrome efficacy was 94.4%in the experimental group and 72.2%in the control group(p<0.05);No drug-related serious adverse reactions were found.Conclusion:Shenqi Hexue decoction can effectively improve the anemia state and activity ability of patients with Qi blood deficiency syndrome in the early stage after PKP,and its possible mechanism involves multi-target regulation such as hematopoietic regulation,microcirculation improvement and inflammation inhibition,with good safety.展开更多
BACKGROUND Gastric cancer is a major global health issue,and the perioperative period critic-ally influences patient outcomes.The different effects of sevoflurane inhalation anesthesia and propofol total intravenous a...BACKGROUND Gastric cancer is a major global health issue,and the perioperative period critic-ally influences patient outcomes.The different effects of sevoflurane inhalation anesthesia and propofol total intravenous anesthesia on intraoperative stability,postoperative complications,and long-term oncologic outcomes in patients with gastric cancer undergoing radical gastrectomy remain unclear.AIM To compare the effects of sevoflurane inhalation anesthesia and propofol total in-travenous anesthesia on clinical outcomes,including intraoperative indicators,postoperative complications,adverse effects,pain scores,and survival.METHODS This single-center retrospective cohort study included 204 patients who underw-ent radical gastrectomy for gastric cancer from February 2019 to December 2022.Patients were assigned to either the sevoflurane group(n=103)or the propofol group(n=101)based on intraoperative anesthetic regimen.Standardized protoc-ols for anesthesia management,intraoperative monitoring,and postoperative analgesia were applied.Baseline characteristics;intraoperative metrics;adverse events;complications;Visual Analog Scale(VAS)scores at 2,4,6,24,and 48 hours;and survival outcomes were retrospectively collected.Group comparisons were performed usingχ2 for categorical variables,t test for continuous variables,RESULTS Baseline demographic and clinical characteristics were similar between groups.No significant differences were observed in intraoperative indicators or most 30-day postoperative outcomes,including length of stay,emergency department visits,and readmission rates.The propofol group showed elevated mean VAS pain score at 24 hours postoperatively,but no differences were found at other time points.The propofol group also had significantly higher postoperative nausea incidence and transiently higher systolic/diastolic blood pressure and heart rate at the time of incision than the sevoflurane group.No significant differences were seen in overall rates or severity of postoperative complications,intraoperative adverse events,or in overall survival and progression-free survival.CONCLUSION In patients undergoing radical gastrectomy for gastric cancer,sevoflurane and propofol anesthesia demonstrated similar profiles regarding intraoperative safety,postoperative complications,adverse events,postoperative pain,and long-term survival.The selection of anesthesia can be personalized without significantly affecting periop-erative or oncologic outcomes.展开更多
Background Adult Fulminant myocarditis(FM)is the more serious form of acute myocarditis,and extracorporeal membrane oxygenation(ECMO)is an effective adjunction that helps to maintain circulation while providing adequa...Background Adult Fulminant myocarditis(FM)is the more serious form of acute myocarditis,and extracorporeal membrane oxygenation(ECMO)is an effective adjunction that helps to maintain circulation while providing adequate treatment.The blood supply of vital organs is guaranteed,which helps patients to survive the acute attack and improves the survival rate of FM.Methods In this study,50 clinical data of adult FM patients received in our hospital from July 2018 to July 2023 were collected for retrospective analysis.According to different treatment methods,they were divided into ECMO group(n=25)and non-ECMO group(n=25).After 14 days of treatment,the level of left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),creatine kinase isoenzymes(CK-MB),cardiac troponinⅠ(cTnⅠ)and brain natriuretic peptide(BNP),and the incidence of complications were compared between the two groups.Results Before treatment,there was no significant difference in cardiac function between the two groups(P>0.05).After 14 days of treatment,ECMO group showed greater decline than non-ECMO group in LVESD and LVEDD,and LVEF was higher than that in the non-ECMO group(P<0.05).The level of CK-MB,cTnⅠ and BNP in ECMO group were lower than those in non-ECMO(P<0.05).The overall incidence of complications was 8% in the ECMO group,which was lower than 32% in the non-ECMO group(P<0.05).Conclusions The early efficacy of ECMO treatment in adult patients with FM is considerable,which is conducive to improving the cardiac function of patients and preventing complications.展开更多
BACKGROUND： Conventional methods （such as occlusion therapy, fine manipulation, complementary, and alternative medicine） take effects slowly, are time and labor consuming, and have uncertain curative effects in the...BACKGROUND： Conventional methods （such as occlusion therapy, fine manipulation, complementary, and alternative medicine） take effects slowly, are time and labor consuming, and have uncertain curative effects in the treatment of amblyopia. Perceptual learning, a new method for treating amblyopia, improves the ability to process signals from the cerebral optic nerve system by specific visual stimulation and visual learning, as well as activation of the visual signal pathway utilizing brain nervous system plasticity. OBJECTIVE： This study investigated and evaluated the curative effects of perceptual learning, which can directionally increase brain plasticity, on the treatment of amblyopia in children. The relationship between curative effect and time was also analyzed. DESIGN： A self-control experiment. SETTING： Visual Science and Optometry Center, People＇s Hospital of Guangxi Zhuang Autonomous Region. PARTICIPANTS： A total of 125 amblyopic children （250 amblyopic eyes）, 73 males, 52 females, averaging （6±2） years of age, received treatment at the Visual Science and Optometry Center, People＇s Hospital of Guangxi Zhuang Autonomous Region between September 2006 and February 2007 and were recruited for this study. All children presented with no structural disease of the eyeballs. Written informed consent for therapeutic regiments was obtained from each child＇s parent. The protocol received approval from the Hospital＇s Ethics Committee. METHODS： Visual function was tested with a perceptual learning system （Research Center for Human Health and Development of Sun Yat-sen University, National Engineering Technique Research Center for Medical Care Implement） for visual noise, position noise, contour discrimination, contrast sensitivity, grating stereogram, and random-dot fusion. These tests helped to evaluate the efficiency of visual information processing of these children, and to determine the degree of defects of the optic nerve cells and the connections of visual cortical neurons. According to results of visual function tests, individualized treatment was adopted for each amblyopia patient using perceptual learning system. One course of treatment lasted one month, and treatment was performed twice every day with two training procedures （each training procedure lasted for ten minutes）. There was a ten-minute time interval between the two training procedures. The training treatment was performed in a quiet and dark environment. Visual acuity and recovery of visual function were tested every month. Original training procedure was continued or adjusted according to the results of visual function. MAIN OUTCOME MEASURES： Visual function change; relationship of curative effects and curative time. RESULTS： A total of 125 amblyopia children were included in the final analysis. The total efficiency of perceptual learning for treating amblyopia in children was 75.2%. Visual acuity began to greatly increase 3 months after treatment （P 〈 0.05）. Visual acuity was best corrected from 0.60 ± 0.23 before treatment to 0.86 ± 0.26 after treatment （P 〈 0.05）. The mean time to reach improved levels with curative effects was （2.82 ± 1.30） months, and to reach a basically cured level was （2.87 ±1.40） months. Percentage of improved visual acuity was the highest [98% （39/40）] in children that received 3 months of treatment and the lowest [55% （31/56）] in children that received 1 month of treatment （P 〈 0.05）. The percentage of basically cured levels with curative effects increased with length of learning time and was the greatest in children that received 4 months of treatment [67% （31/46）, P 〈 0.05]. CONCLUSION： Perceptual learning rapidly and remarkably improves visual function of amblyopia children; however, the curative effects are first apparent two and three months after intervention.展开更多
The anti-fungus mechanisms and curative effects of cinnamon oil and pogostemon oil complexes to wards intestinal Candida infections were investigat ed.We measured the minimal inhibitory concentra tion(MIC) values of t...The anti-fungus mechanisms and curative effects of cinnamon oil and pogostemon oil complexes to wards intestinal Candida infections were investigat ed.We measured the minimal inhibitory concentra tion(MIC) values of the complexes against Candida using proportionally-diluted test-tube medium and examined the evolution of the morphology and structures of Candida albicans using scanning electronic microscopy(SEM) and transmission elec tronic microscopy(TEM).We found that the aver age MIC values of the complexes against the fung were 0.064 mg/mL(cinnamon oil),0.032 mg/mL(pogostemon oil) for Candida albicans,0.129 mg/mL(cinnamon oil),0.064 mg/mL(pogostemon oil for Candida tropicalis,and 0.129 mg/mL(cinnamon oil),0.064 mg/mL(pogostemon oil),for Candida krusei.SEM examination over a 24-48 h period showed that the morphology of Candida albicans cells changed significantly.Irregular hollows ap peared on the surfaces,inside organelles were destroyed and the cells burst after treatment.TEM examination over a 48-72 h period indicated that the cell walls were damaged,organelles were destroyed and most cytoplasms became empty bubbles.Sixty intestinal Candida-infected patients were treated with a capsule containing cinnamon and pogostemon oil.The curative ratio was 71.67%(43/60),and the improvement ratio was 28.33%(17/60),giving a to talratio of 100%.Thus,the cinnamonoil and pogostemon oil complexes had strong anti-funguseffectsag ainst Candida albicans,Candidatropicalis,and Candidakrusei.They impacted the morphology and sub-micro structures of the fungus within48-72h,and eventually denatured and killed the cells.The complexes have also shown considerable curative effects to intestinal Candida infections.展开更多
Beating-acupuncture therapy is developed by Li Xutang, Director of the Section of TCM in the Jingdezhen Municipal First Hospital. Amng the 100 cases in the beating-acupuncture group, 85 cases were cured and 11 cases i...Beating-acupuncture therapy is developed by Li Xutang, Director of the Section of TCM in the Jingdezhen Municipal First Hospital. Amng the 100 cases in the beating-acupuncture group, 85 cases were cured and 11 cases improved, the cure rate was 85 %; Of the 50 cases in the filiform needle acupuncture group, 25 cases were cured and 23 improved, the cure rate was 50 %. There was a statis-tically significant difference(P<0.01 ) between the two grdrips. It is indicated that the curative effect of beating-acupuncture on cervical spondylopathy is obviously superior to that of fili form-needle acupuncture, which provides a new therapy without traumatic pain for clinical treatment of cervical spondylopathy,展开更多
In order to investigate the relationship between concentration of methimazole(MMTand clinical curative efficacy,the concentration of MMI in Plasma and thyroid tissue was measuredin 26 patients with Graves' disease...In order to investigate the relationship between concentration of methimazole(MMTand clinical curative efficacy,the concentration of MMI in Plasma and thyroid tissue was measuredin 26 patients with Graves' disease by HPLC,meanwhile their T-lymphocyte subsets,thyroid autoimmune antibodies and serum immunoglobulin were also measured.The results showed: ① The plasmaand intrathyroid concentrations of MMI of recovery group were much higher than those of unrecovery group(P<0.001).② The hardness of thyroid had a significant effect on the concentration ofMMI in thyroid.③Plasma concentration of MMI in the patients with no or 1￣2-degree enlargement of thyroid was much higher than that in the patients with 3-degree enlargement of thyroid(P<0.001). In addition, the plasma concentration of MMI in the subjects with soft thyroid was mudhigher than that in those with hard thyroid(P<0.001).Our study demonstrated that MMI playeda role in the immune supression of thyroid autoimmune antibodies and the immune regulation of Tand B-lymphocytes.Effective MMI concentration in the plasma and intrathyroid is the key of thesuccessful clinical treatment and correlates with the size and hardness of thyroid.展开更多
Objective:To evaluate the curative effect of"Cold-Dampness Epidemic Prescription(寒湿疫方)"on the main symptoms of quarantined people in community based on real-world research data,and to provide scientific ...Objective:To evaluate the curative effect of"Cold-Dampness Epidemic Prescription(寒湿疫方)"on the main symptoms of quarantined people in community based on real-world research data,and to provide scientific basis for Chinese medicine to fight Coronavirus disease 2019 under the"Wuchang Model".Methods:From February 4,2020 to March 5,2020,the data of community quarantined people who only took"Cold-Dampness Epidemic Prescription(寒湿疫方)"under the management of"Wuchang Model"were collected,and the demographic characteristics,basic diseases,distribution of sick people,treatment process,disappearance time of eight clinical symptoms,adverse reactions and clinical outcomes of patients were statistically analyzed.Results:A total of 951 quarantined people in COVID-19 community were included,including 440 males(46.27%)and 511 females(53.73%),the oldest was 89 years old,the youngest was 2 years old,and the average age was 43.34 years old;Among the quarantined population in the community,there were 141 cases diagnosed by CDC(14.83%),CDC excluded 810 cases(85.17%);106 cases of CDC were diagnosed as COVID-19,accounting for 47.96%of the self-reported cases,and 311 cases(32.70%)had previous medical history;696(73.19%)had no obvious symptoms,and 255(26.81%)developed fever,fatigue,cough,sputum,shortness of breath,loss of appetite,diarrhea and mood,of which 187(19.66%)had cough symptoms,followed by sputum coughing(14.30%)and fever(13.56%).Conclusion:"Cold-Dampness Epidemic Prescription(寒湿疫方)"is effective in treating the clinical symptoms of COVID-19 without obvious adverse reactions.展开更多
Objective:To investigate the curative effect of Rhizoma Imperata in the treatment of patients with community-acquired pneumonia and its influence on inflammatory factors related to TLR4/NF-κB signaling pathway,so as ...Objective:To investigate the curative effect of Rhizoma Imperata in the treatment of patients with community-acquired pneumonia and its influence on inflammatory factors related to TLR4/NF-κB signaling pathway,so as to seek new drugs for the treatment of community-acquired pneumonia.Methods:120 patients with community-acquired pneumonia who were treated in Department of respiratory medicine,the First Affiliated Hospital of Hainan Medical College from November 2019 to September 2020 were collected and randomly divided into control group and experimental group,with 60 patients in each group.The control group was given cefuroxime sodium injection,and the experimental group was given cefuroxime sodium injection+Baimao root decoction.The levels of high-sensitivity C-reactive protein(CRP)and the level of serum CRP in the two groups before and after treatment were compared Objective To observe the expression of procalcitonin(PCT),IL-6,IL-8,TNF-αand TLR4/NF-κB mRNA levels,and to observe the effect of Radix Imperata Rubra on community-acquired pneumonia.Results:The fever,cough,expectoration subsided time and chest CT inflammation absorption time of the experimental group were shorter than those of the control group,the difference was statistically significant(P<0.05);the total effective rate of the experimental group(96.67%)was higher than that of the control group(85%),the difference was statistically significant(P<0.05);after treatment,the serum CRP,PCT,IL-6,IL-8,TNF-αin the two groups were lower than before,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05),There was statistical significance(P<0.05);after treatment,TLR4/NF-κB mRNA of the two groups were decreased,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion:In the treatment of cap,Rhizoma Imperata can reduce the levels of CRP,PCT,IL-6,IL-8 and TNF-α.The mechanism is related to inhibiting the activation of TLR4/NF-κB signaling pathway,so as to reduce the release of inflammatory factors and improve clinical symptoms.展开更多
BACKGROUND In the field of clinical intestinal preparation,compound polyethylene glycol electrolyte solution(SF-PEG)is a commonly used intestinal cleaner.However,practice has shown that using only a single polyethylen...BACKGROUND In the field of clinical intestinal preparation,compound polyethylene glycol electrolyte solution(SF-PEG)is a commonly used intestinal cleaner.However,practice has shown that using only a single polyethylene glycol formulation often fails to achieve the desired intestinal preparation effect.Linalotide has a unique mechanism of action,which can effectively enhance the secretion of small intestinal fluid and promote intestinal peristalsis.The combination of linaclotide and SF-PEG may provide a better solution for intestinal preparation and improve the quality of intestinal cleaning.Therefore,exploring the application value and clinical efficacy of linaclotide capsules combined with SF-PEG in intestinal preparation is of great clinical significance.AIM To explore the effects of the combination of linaclotide capsules and SF-PEG,including its efficacy in intestinal preparation and patient tolerance.METHODS To investigate the differences in the effectiveness of different bowel preparation plans in colonoscopy,this article conducted a comprehensive and detailed retrospective analysis of the medical records of patients who underwent colonoscopy from January 2023 to December 2023.In this study,116 patients were accurately divided into three groups based on the different intestinal preparation drugs used before colonoscopy.Among them,group A consisted of 29 patients who underwent intestinal preparation using 3 liters of SF-PEG combined with linaclotide;group B consists of 50 patients who underwent intestinal preparation using 3 liters of SF-PEG;group C consisted of 37 patients who underwent intestinal preparation using a combination of 2-liter SF-PEC and linaclotide.Subsequently,this article evaluated the quality of intestinal preparation in these three groups of patients,using the Boston bowel preparation scale(BBPS)as a quantitative indicator,while comparing multiple indicators such as intestinal preparation completion rate and detection of positive lesions,providing a strong basis for optimizing clinical intestinal preparation plans.RESULTS No statistically significant differences were found in BBPS scores(7.75±1.23,7.69±1.14,and 7.66±1.31;P=0.240),bowel preparation completion rates(96.55%,90.00%,and 97.30%;P=0.293),adenoma detection rates(20.69%,38.00%,and 32.43%;P=0.281),polyp detection rates(34.48%,50.00%,37.84%;P=0.326),insertion time(6.03±4.34,6.12±3.60,and 5.33±2.42;P=0.584),and patient satisfaction rates(89.66%,84.00%,and 97.30%;P=0.398)among the three groups.However,statistically significant differences were observed in withdrawal time(7.45±2.91,9.02±3.54,and 6.86±2.66;P=0.027)and adverse reaction rates(6.90%,20.00%,and 2.70%;P=0.029)among the three groups.Multiple comparisons showed that group C had significantly lower withdrawal time and adverse reaction rates than group B(P=0.013,P=0.016).CONCLUSION Linaclotide capsules show a trend in improving bowel preparation quality and reducing the dosage of SF-PEG.展开更多
BACKGROUND Gastrointestinal(GI)dysfunction is common after laparoscopic radical gastrectomy for gastric cancer and affects rehabilitation.While conventional treatments can alleviate symptoms to a certain extent,they o...BACKGROUND Gastrointestinal(GI)dysfunction is common after laparoscopic radical gastrectomy for gastric cancer and affects rehabilitation.While conventional treatments can alleviate symptoms to a certain extent,they often fail to fully address the issue of insufficient GI motility.The GI motility therapeutic apparatus promotes dynamic recovery by simulating GI electric waves,whereas acupuncture regulates zang-fu qi movement,both offering effective interventions.However,there are few clinical studies investigating the combined use of GI motility therapy and acupuncture to promote GI function recovery in patients after GI laparoscopic radical surgery.AIM To evaluate the effects of combining GI motility therapy devices with acupuncture on GI function in patients undergoing radical laparoscopic surgery.METHODS This retrospective study included 196 patients who underwent radical GI endoscopic surgery at the Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center),School of Medicine,Tongji University,from June 2022 to May 2024.Patients were classified into a normal group(conventional treatment,n=96)and an integrated group(conventional+GI motility therapy device+acupuncture,n=100).The effects on GI function,hormone levels preand post-treatment,GI symptoms,immune function,adverse reactions,and patient satisfaction in both groups were assessed.RESULTS Compared with the normal group,the integrated group demonstrated significantly better overall effectiveness(93.00%vs 84.3%;P<0.05)and shorter durations for first exhaust,feeding,defecation,and hospital stay(P<0.05).Post-treatment,the integrated group had lower gastrin and GI symptom rating scale scores and higher motilin,vasoactive intestinal peptide,and immune marker(CD3+,CD4+,CD4+/CD8+,and natural killer cells)levels(P<0.05).The integrated group,compared to the normal group,also reported fewer adverse reactions(5.00%vs 14.58%)and higher patient satisfaction(97.00%vs 84.38%),both statistically significant(P<0.05).CONCLUSION The combination of a GI motility therapy device and acupuncture promotes GI function recovery after radical gastrectomy,regulates GI hormones and immune function,and is safe and effective.展开更多
BACKGROUND Long-term use of proton pump inhibitors(PPIs)has been associated with poten-tial adverse effects,including an increased risk of gastric cancer.Despite wide-spread use awareness of these risks among physicia...BACKGROUND Long-term use of proton pump inhibitors(PPIs)has been associated with poten-tial adverse effects,including an increased risk of gastric cancer.Despite wide-spread use awareness of these risks among physicians varies considerably.Under-standing physicians’perceptions and prescribing behaviors is critical to impro-ving patient safety and promoting evidence-based practices.This study aimed to assess the level of awareness and risk perception among gastroenterologists and non-gastroenterologists regarding prolonged PPI use and its association with gastric malignancy.AIM To assess physicians’awareness of gastric cancer risk associated with long-term PPI use and compare perceptions between specialties.METHODS A cross-sectional observational study was conducted among 33 physicians(15 gastroenterologists and 18 non-gastroenterologists)in Israel.Participants com-pleted a structured questionnaire evaluating knowledge,attitudes,and prescri-bing behaviors related to PPI use.Data were analyzed using descriptive statistics and nonparametric tests to assess differences between groups and correlation patterns.Ethical approval and informed consent were obtained.RESULTS Gastroenterologists demonstrated significantly higher awareness of the potential gastric cancer risks linked to prolonged PPI use(mean awareness score:6.9±1.2)compared with non-gastroenterologists(4.1±1.3,P<0.01).Despite their awa-reness 80%of gastroenterologists reported frequent long-term prescribing.Non-parametric correlation analysis revealed associations between specialty,know-ledge level,and prescribing habits.Several misconceptions about cancer risk mechanisms were identified across specialties.CONCLUSION Physician awareness regarding gastric cancer risk of long-term PPI use remains inconsistent,especially among non-specialists,emphasizing the need for targeted educational programs and clearer prescribing guidelines.展开更多
Objective: to investigate the clinical application value of trimetazidine and Danhong injection, observe its application in the treatment of patients with angina pectoris, and analyze its feasibility and effectiveness...Objective: to investigate the clinical application value of trimetazidine and Danhong injection, observe its application in the treatment of patients with angina pectoris, and analyze its feasibility and effectiveness. Methods: 60 patients with angina pectoris from January 2019 to June 2020 were included in this study. After the patients were judged to meet the inclusion criteria, they were treated in groups and studied simultaneously. The study aimed at Danhong injection combined with trimetazidine treatment (30 cases in the observation group) and trimetazidine treatment alone (30 cases in the control group), and observed the treatment efficiency and angina pectoris status of each group after group treatment, and compared the two groups after statistical analysis. Results: the score of angina related progress in the observation group showed a very prominent advantage over that in the control group. Therefore, the treatment method in the observation group had higher clinical feasibility. The statistical method of data packet processing showed P < 0.05, and the test results were significant. Conclusion: Danhong injection combined with trimetazidine is more effective in the treatment of angina pectoris, which can better control the patient's disease development and is worthy of clinical promotion.展开更多
基金the Guo Wei Expert Work station,Yunnan Province(202305AF-150151).
文摘Objective:After percutaneous kyphoplasty(PKP),patients with pathological vertebral fractures of thoracolumbar metastases often have Qi and blood deficiency syndrome and hidden blood loss,resulting in postoperative debilitation syndrome.This study aimed to evaluate the clinical efficacy and mechanism of Shenqi Hexue Decoction on early postoperative recovery of such patients.Methods:36 Patients were randomly divided into an experimental group(Shenqi Hexue Decoction+conventional treatment)and a control group(conventional treatment).The changes of hemoglobin(HB),Karnofsky functional status(KPS)score,and TCM syndrome score on the 1st,4th,and 7th day after operation were observed.Results:The HB value of the experimental group was significantly higher than that of the control group on the 4th and 7th days after operation(p<0.01),and the maximum decline value of HB decreased by 42.1%(p<0.001);The improvement rate of KPS score in the experimental group was 94.4%on the 7th day after operation,which was significantly better than 66.7%in the control group(p<0.05).The total effective rate of TCM syndrome efficacy was 94.4%in the experimental group and 72.2%in the control group(p<0.05);No drug-related serious adverse reactions were found.Conclusion:Shenqi Hexue decoction can effectively improve the anemia state and activity ability of patients with Qi blood deficiency syndrome in the early stage after PKP,and its possible mechanism involves multi-target regulation such as hematopoietic regulation,microcirculation improvement and inflammation inhibition,with good safety.
文摘BACKGROUND Gastric cancer is a major global health issue,and the perioperative period critic-ally influences patient outcomes.The different effects of sevoflurane inhalation anesthesia and propofol total intravenous anesthesia on intraoperative stability,postoperative complications,and long-term oncologic outcomes in patients with gastric cancer undergoing radical gastrectomy remain unclear.AIM To compare the effects of sevoflurane inhalation anesthesia and propofol total in-travenous anesthesia on clinical outcomes,including intraoperative indicators,postoperative complications,adverse effects,pain scores,and survival.METHODS This single-center retrospective cohort study included 204 patients who underw-ent radical gastrectomy for gastric cancer from February 2019 to December 2022.Patients were assigned to either the sevoflurane group(n=103)or the propofol group(n=101)based on intraoperative anesthetic regimen.Standardized protoc-ols for anesthesia management,intraoperative monitoring,and postoperative analgesia were applied.Baseline characteristics;intraoperative metrics;adverse events;complications;Visual Analog Scale(VAS)scores at 2,4,6,24,and 48 hours;and survival outcomes were retrospectively collected.Group comparisons were performed usingχ2 for categorical variables,t test for continuous variables,RESULTS Baseline demographic and clinical characteristics were similar between groups.No significant differences were observed in intraoperative indicators or most 30-day postoperative outcomes,including length of stay,emergency department visits,and readmission rates.The propofol group showed elevated mean VAS pain score at 24 hours postoperatively,but no differences were found at other time points.The propofol group also had significantly higher postoperative nausea incidence and transiently higher systolic/diastolic blood pressure and heart rate at the time of incision than the sevoflurane group.No significant differences were seen in overall rates or severity of postoperative complications,intraoperative adverse events,or in overall survival and progression-free survival.CONCLUSION In patients undergoing radical gastrectomy for gastric cancer,sevoflurane and propofol anesthesia demonstrated similar profiles regarding intraoperative safety,postoperative complications,adverse events,postoperative pain,and long-term survival.The selection of anesthesia can be personalized without significantly affecting periop-erative or oncologic outcomes.
基金supported by the Natural Science Foundation of Hunan Province,China(No.2021JJ40505/No.2021JJ30619/No.2020JJ8002)the Scientific Research Project of Hunan Provincial Health Commission(No.202210004450)。
文摘Background Adult Fulminant myocarditis(FM)is the more serious form of acute myocarditis,and extracorporeal membrane oxygenation(ECMO)is an effective adjunction that helps to maintain circulation while providing adequate treatment.The blood supply of vital organs is guaranteed,which helps patients to survive the acute attack and improves the survival rate of FM.Methods In this study,50 clinical data of adult FM patients received in our hospital from July 2018 to July 2023 were collected for retrospective analysis.According to different treatment methods,they were divided into ECMO group(n=25)and non-ECMO group(n=25).After 14 days of treatment,the level of left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),creatine kinase isoenzymes(CK-MB),cardiac troponinⅠ(cTnⅠ)and brain natriuretic peptide(BNP),and the incidence of complications were compared between the two groups.Results Before treatment,there was no significant difference in cardiac function between the two groups(P>0.05).After 14 days of treatment,ECMO group showed greater decline than non-ECMO group in LVESD and LVEDD,and LVEF was higher than that in the non-ECMO group(P<0.05).The level of CK-MB,cTnⅠ and BNP in ECMO group were lower than those in non-ECMO(P<0.05).The overall incidence of complications was 8% in the ECMO group,which was lower than 32% in the non-ECMO group(P<0.05).Conclusions The early efficacy of ECMO treatment in adult patients with FM is considerable,which is conducive to improving the cardiac function of patients and preventing complications.
基金Grant from Major Scientific Research Program of Medical Treatment and Public Health of Guangxi Zhuang Autonomous Region, No.200730
文摘BACKGROUND： Conventional methods （such as occlusion therapy, fine manipulation, complementary, and alternative medicine） take effects slowly, are time and labor consuming, and have uncertain curative effects in the treatment of amblyopia. Perceptual learning, a new method for treating amblyopia, improves the ability to process signals from the cerebral optic nerve system by specific visual stimulation and visual learning, as well as activation of the visual signal pathway utilizing brain nervous system plasticity. OBJECTIVE： This study investigated and evaluated the curative effects of perceptual learning, which can directionally increase brain plasticity, on the treatment of amblyopia in children. The relationship between curative effect and time was also analyzed. DESIGN： A self-control experiment. SETTING： Visual Science and Optometry Center, People＇s Hospital of Guangxi Zhuang Autonomous Region. PARTICIPANTS： A total of 125 amblyopic children （250 amblyopic eyes）, 73 males, 52 females, averaging （6±2） years of age, received treatment at the Visual Science and Optometry Center, People＇s Hospital of Guangxi Zhuang Autonomous Region between September 2006 and February 2007 and were recruited for this study. All children presented with no structural disease of the eyeballs. Written informed consent for therapeutic regiments was obtained from each child＇s parent. The protocol received approval from the Hospital＇s Ethics Committee. METHODS： Visual function was tested with a perceptual learning system （Research Center for Human Health and Development of Sun Yat-sen University, National Engineering Technique Research Center for Medical Care Implement） for visual noise, position noise, contour discrimination, contrast sensitivity, grating stereogram, and random-dot fusion. These tests helped to evaluate the efficiency of visual information processing of these children, and to determine the degree of defects of the optic nerve cells and the connections of visual cortical neurons. According to results of visual function tests, individualized treatment was adopted for each amblyopia patient using perceptual learning system. One course of treatment lasted one month, and treatment was performed twice every day with two training procedures （each training procedure lasted for ten minutes）. There was a ten-minute time interval between the two training procedures. The training treatment was performed in a quiet and dark environment. Visual acuity and recovery of visual function were tested every month. Original training procedure was continued or adjusted according to the results of visual function. MAIN OUTCOME MEASURES： Visual function change; relationship of curative effects and curative time. RESULTS： A total of 125 amblyopia children were included in the final analysis. The total efficiency of perceptual learning for treating amblyopia in children was 75.2%. Visual acuity began to greatly increase 3 months after treatment （P 〈 0.05）. Visual acuity was best corrected from 0.60 ± 0.23 before treatment to 0.86 ± 0.26 after treatment （P 〈 0.05）. The mean time to reach improved levels with curative effects was （2.82 ± 1.30） months, and to reach a basically cured level was （2.87 ±1.40） months. Percentage of improved visual acuity was the highest [98% （39/40）] in children that received 3 months of treatment and the lowest [55% （31/56）] in children that received 1 month of treatment （P 〈 0.05）. The percentage of basically cured levels with curative effects increased with length of learning time and was the greatest in children that received 4 months of treatment [67% （31/46）, P 〈 0.05]. CONCLUSION： Perceptual learning rapidly and remarkably improves visual function of amblyopia children; however, the curative effects are first apparent two and three months after intervention.
文摘The anti-fungus mechanisms and curative effects of cinnamon oil and pogostemon oil complexes to wards intestinal Candida infections were investigat ed.We measured the minimal inhibitory concentra tion(MIC) values of the complexes against Candida using proportionally-diluted test-tube medium and examined the evolution of the morphology and structures of Candida albicans using scanning electronic microscopy(SEM) and transmission elec tronic microscopy(TEM).We found that the aver age MIC values of the complexes against the fung were 0.064 mg/mL(cinnamon oil),0.032 mg/mL(pogostemon oil) for Candida albicans,0.129 mg/mL(cinnamon oil),0.064 mg/mL(pogostemon oil for Candida tropicalis,and 0.129 mg/mL(cinnamon oil),0.064 mg/mL(pogostemon oil),for Candida krusei.SEM examination over a 24-48 h period showed that the morphology of Candida albicans cells changed significantly.Irregular hollows ap peared on the surfaces,inside organelles were destroyed and the cells burst after treatment.TEM examination over a 48-72 h period indicated that the cell walls were damaged,organelles were destroyed and most cytoplasms became empty bubbles.Sixty intestinal Candida-infected patients were treated with a capsule containing cinnamon and pogostemon oil.The curative ratio was 71.67%(43/60),and the improvement ratio was 28.33%(17/60),giving a to talratio of 100%.Thus,the cinnamonoil and pogostemon oil complexes had strong anti-funguseffectsag ainst Candida albicans,Candidatropicalis,and Candidakrusei.They impacted the morphology and sub-micro structures of the fungus within48-72h,and eventually denatured and killed the cells.The complexes have also shown considerable curative effects to intestinal Candida infections.
文摘Beating-acupuncture therapy is developed by Li Xutang, Director of the Section of TCM in the Jingdezhen Municipal First Hospital. Amng the 100 cases in the beating-acupuncture group, 85 cases were cured and 11 cases improved, the cure rate was 85 %; Of the 50 cases in the filiform needle acupuncture group, 25 cases were cured and 23 improved, the cure rate was 50 %. There was a statis-tically significant difference(P<0.01 ) between the two grdrips. It is indicated that the curative effect of beating-acupuncture on cervical spondylopathy is obviously superior to that of fili form-needle acupuncture, which provides a new therapy without traumatic pain for clinical treatment of cervical spondylopathy,
文摘In order to investigate the relationship between concentration of methimazole(MMTand clinical curative efficacy,the concentration of MMI in Plasma and thyroid tissue was measuredin 26 patients with Graves' disease by HPLC,meanwhile their T-lymphocyte subsets,thyroid autoimmune antibodies and serum immunoglobulin were also measured.The results showed: ① The plasmaand intrathyroid concentrations of MMI of recovery group were much higher than those of unrecovery group(P<0.001).② The hardness of thyroid had a significant effect on the concentration ofMMI in thyroid.③Plasma concentration of MMI in the patients with no or 1￣2-degree enlargement of thyroid was much higher than that in the patients with 3-degree enlargement of thyroid(P<0.001). In addition, the plasma concentration of MMI in the subjects with soft thyroid was mudhigher than that in those with hard thyroid(P<0.001).Our study demonstrated that MMI playeda role in the immune supression of thyroid autoimmune antibodies and the immune regulation of Tand B-lymphocytes.Effective MMI concentration in the plasma and intrathyroid is the key of thesuccessful clinical treatment and correlates with the size and hardness of thyroid.
基金The National Key Research and Development Plan"Public Safety Risk Prevention and Control and Emergency Technical Equipment"Key Project"Clinical Evaluation Research on Chinese Medicine Intervention in COVID-19 Recovery Period"(2020YFC0845000)。
文摘Objective:To evaluate the curative effect of"Cold-Dampness Epidemic Prescription(寒湿疫方)"on the main symptoms of quarantined people in community based on real-world research data,and to provide scientific basis for Chinese medicine to fight Coronavirus disease 2019 under the"Wuchang Model".Methods:From February 4,2020 to March 5,2020,the data of community quarantined people who only took"Cold-Dampness Epidemic Prescription(寒湿疫方)"under the management of"Wuchang Model"were collected,and the demographic characteristics,basic diseases,distribution of sick people,treatment process,disappearance time of eight clinical symptoms,adverse reactions and clinical outcomes of patients were statistically analyzed.Results:A total of 951 quarantined people in COVID-19 community were included,including 440 males(46.27%)and 511 females(53.73%),the oldest was 89 years old,the youngest was 2 years old,and the average age was 43.34 years old;Among the quarantined population in the community,there were 141 cases diagnosed by CDC(14.83%),CDC excluded 810 cases(85.17%);106 cases of CDC were diagnosed as COVID-19,accounting for 47.96%of the self-reported cases,and 311 cases(32.70%)had previous medical history;696(73.19%)had no obvious symptoms,and 255(26.81%)developed fever,fatigue,cough,sputum,shortness of breath,loss of appetite,diarrhea and mood,of which 187(19.66%)had cough symptoms,followed by sputum coughing(14.30%)and fever(13.56%).Conclusion:"Cold-Dampness Epidemic Prescription(寒湿疫方)"is effective in treating the clinical symptoms of COVID-19 without obvious adverse reactions.
基金National Natural Science Foundation of China(No.81660010,31660329,8191101552)。
文摘Objective:To investigate the curative effect of Rhizoma Imperata in the treatment of patients with community-acquired pneumonia and its influence on inflammatory factors related to TLR4/NF-κB signaling pathway,so as to seek new drugs for the treatment of community-acquired pneumonia.Methods:120 patients with community-acquired pneumonia who were treated in Department of respiratory medicine,the First Affiliated Hospital of Hainan Medical College from November 2019 to September 2020 were collected and randomly divided into control group and experimental group,with 60 patients in each group.The control group was given cefuroxime sodium injection,and the experimental group was given cefuroxime sodium injection+Baimao root decoction.The levels of high-sensitivity C-reactive protein(CRP)and the level of serum CRP in the two groups before and after treatment were compared Objective To observe the expression of procalcitonin(PCT),IL-6,IL-8,TNF-αand TLR4/NF-κB mRNA levels,and to observe the effect of Radix Imperata Rubra on community-acquired pneumonia.Results:The fever,cough,expectoration subsided time and chest CT inflammation absorption time of the experimental group were shorter than those of the control group,the difference was statistically significant(P<0.05);the total effective rate of the experimental group(96.67%)was higher than that of the control group(85%),the difference was statistically significant(P<0.05);after treatment,the serum CRP,PCT,IL-6,IL-8,TNF-αin the two groups were lower than before,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05),There was statistical significance(P<0.05);after treatment,TLR4/NF-κB mRNA of the two groups were decreased,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion:In the treatment of cap,Rhizoma Imperata can reduce the levels of CRP,PCT,IL-6,IL-8 and TNF-α.The mechanism is related to inhibiting the activation of TLR4/NF-κB signaling pathway,so as to reduce the release of inflammatory factors and improve clinical symptoms.
基金Supported by the Science and Technology Program of Rui’an,No.MS2023030.
文摘BACKGROUND In the field of clinical intestinal preparation,compound polyethylene glycol electrolyte solution(SF-PEG)is a commonly used intestinal cleaner.However,practice has shown that using only a single polyethylene glycol formulation often fails to achieve the desired intestinal preparation effect.Linalotide has a unique mechanism of action,which can effectively enhance the secretion of small intestinal fluid and promote intestinal peristalsis.The combination of linaclotide and SF-PEG may provide a better solution for intestinal preparation and improve the quality of intestinal cleaning.Therefore,exploring the application value and clinical efficacy of linaclotide capsules combined with SF-PEG in intestinal preparation is of great clinical significance.AIM To explore the effects of the combination of linaclotide capsules and SF-PEG,including its efficacy in intestinal preparation and patient tolerance.METHODS To investigate the differences in the effectiveness of different bowel preparation plans in colonoscopy,this article conducted a comprehensive and detailed retrospective analysis of the medical records of patients who underwent colonoscopy from January 2023 to December 2023.In this study,116 patients were accurately divided into three groups based on the different intestinal preparation drugs used before colonoscopy.Among them,group A consisted of 29 patients who underwent intestinal preparation using 3 liters of SF-PEG combined with linaclotide;group B consists of 50 patients who underwent intestinal preparation using 3 liters of SF-PEG;group C consisted of 37 patients who underwent intestinal preparation using a combination of 2-liter SF-PEC and linaclotide.Subsequently,this article evaluated the quality of intestinal preparation in these three groups of patients,using the Boston bowel preparation scale(BBPS)as a quantitative indicator,while comparing multiple indicators such as intestinal preparation completion rate and detection of positive lesions,providing a strong basis for optimizing clinical intestinal preparation plans.RESULTS No statistically significant differences were found in BBPS scores(7.75±1.23,7.69±1.14,and 7.66±1.31;P=0.240),bowel preparation completion rates(96.55%,90.00%,and 97.30%;P=0.293),adenoma detection rates(20.69%,38.00%,and 32.43%;P=0.281),polyp detection rates(34.48%,50.00%,37.84%;P=0.326),insertion time(6.03±4.34,6.12±3.60,and 5.33±2.42;P=0.584),and patient satisfaction rates(89.66%,84.00%,and 97.30%;P=0.398)among the three groups.However,statistically significant differences were observed in withdrawal time(7.45±2.91,9.02±3.54,and 6.86±2.66;P=0.027)and adverse reaction rates(6.90%,20.00%,and 2.70%;P=0.029)among the three groups.Multiple comparisons showed that group C had significantly lower withdrawal time and adverse reaction rates than group B(P=0.013,P=0.016).CONCLUSION Linaclotide capsules show a trend in improving bowel preparation quality and reducing the dosage of SF-PEG.
基金Supported by Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center),Key Project within the Hospital,No.2024CRZD007Shanghai Municipal Health Commission,2024-2025 Traditional Chinese Medicine Research Project,No.2024QN063.
文摘BACKGROUND Gastrointestinal(GI)dysfunction is common after laparoscopic radical gastrectomy for gastric cancer and affects rehabilitation.While conventional treatments can alleviate symptoms to a certain extent,they often fail to fully address the issue of insufficient GI motility.The GI motility therapeutic apparatus promotes dynamic recovery by simulating GI electric waves,whereas acupuncture regulates zang-fu qi movement,both offering effective interventions.However,there are few clinical studies investigating the combined use of GI motility therapy and acupuncture to promote GI function recovery in patients after GI laparoscopic radical surgery.AIM To evaluate the effects of combining GI motility therapy devices with acupuncture on GI function in patients undergoing radical laparoscopic surgery.METHODS This retrospective study included 196 patients who underwent radical GI endoscopic surgery at the Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center),School of Medicine,Tongji University,from June 2022 to May 2024.Patients were classified into a normal group(conventional treatment,n=96)and an integrated group(conventional+GI motility therapy device+acupuncture,n=100).The effects on GI function,hormone levels preand post-treatment,GI symptoms,immune function,adverse reactions,and patient satisfaction in both groups were assessed.RESULTS Compared with the normal group,the integrated group demonstrated significantly better overall effectiveness(93.00%vs 84.3%;P<0.05)and shorter durations for first exhaust,feeding,defecation,and hospital stay(P<0.05).Post-treatment,the integrated group had lower gastrin and GI symptom rating scale scores and higher motilin,vasoactive intestinal peptide,and immune marker(CD3+,CD4+,CD4+/CD8+,and natural killer cells)levels(P<0.05).The integrated group,compared to the normal group,also reported fewer adverse reactions(5.00%vs 14.58%)and higher patient satisfaction(97.00%vs 84.38%),both statistically significant(P<0.05).CONCLUSION The combination of a GI motility therapy device and acupuncture promotes GI function recovery after radical gastrectomy,regulates GI hormones and immune function,and is safe and effective.
文摘BACKGROUND Long-term use of proton pump inhibitors(PPIs)has been associated with poten-tial adverse effects,including an increased risk of gastric cancer.Despite wide-spread use awareness of these risks among physicians varies considerably.Under-standing physicians’perceptions and prescribing behaviors is critical to impro-ving patient safety and promoting evidence-based practices.This study aimed to assess the level of awareness and risk perception among gastroenterologists and non-gastroenterologists regarding prolonged PPI use and its association with gastric malignancy.AIM To assess physicians’awareness of gastric cancer risk associated with long-term PPI use and compare perceptions between specialties.METHODS A cross-sectional observational study was conducted among 33 physicians(15 gastroenterologists and 18 non-gastroenterologists)in Israel.Participants com-pleted a structured questionnaire evaluating knowledge,attitudes,and prescri-bing behaviors related to PPI use.Data were analyzed using descriptive statistics and nonparametric tests to assess differences between groups and correlation patterns.Ethical approval and informed consent were obtained.RESULTS Gastroenterologists demonstrated significantly higher awareness of the potential gastric cancer risks linked to prolonged PPI use(mean awareness score:6.9±1.2)compared with non-gastroenterologists(4.1±1.3,P<0.01).Despite their awa-reness 80%of gastroenterologists reported frequent long-term prescribing.Non-parametric correlation analysis revealed associations between specialty,know-ledge level,and prescribing habits.Several misconceptions about cancer risk mechanisms were identified across specialties.CONCLUSION Physician awareness regarding gastric cancer risk of long-term PPI use remains inconsistent,especially among non-specialists,emphasizing the need for targeted educational programs and clearer prescribing guidelines.
文摘Objective: to investigate the clinical application value of trimetazidine and Danhong injection, observe its application in the treatment of patients with angina pectoris, and analyze its feasibility and effectiveness. Methods: 60 patients with angina pectoris from January 2019 to June 2020 were included in this study. After the patients were judged to meet the inclusion criteria, they were treated in groups and studied simultaneously. The study aimed at Danhong injection combined with trimetazidine treatment (30 cases in the observation group) and trimetazidine treatment alone (30 cases in the control group), and observed the treatment efficiency and angina pectoris status of each group after group treatment, and compared the two groups after statistical analysis. Results: the score of angina related progress in the observation group showed a very prominent advantage over that in the control group. Therefore, the treatment method in the observation group had higher clinical feasibility. The statistical method of data packet processing showed P < 0.05, and the test results were significant. Conclusion: Danhong injection combined with trimetazidine is more effective in the treatment of angina pectoris, which can better control the patient's disease development and is worthy of clinical promotion.
