Nonfused ring electron acceptors(NFREAs)have attracted much attention due to their concise synthetic routes and low cost.However,developing high-performance NFREAs with simple structure remains a great challenge.In th...Nonfused ring electron acceptors(NFREAs)have attracted much attention due to their concise synthetic routes and low cost.However,developing high-performance NFREAs with simple structure remains a great challenge.In this work,a simple building block(POBT)with noncovalently conformational locks(No CLs)was designed and synthesized.Single-crystal X-ray study indicated the presence of S…O NOCLs in POBT,thus enabling it to possess a coplanar conformation comparable to that of fused-ring CPT.Two novel NFREAs based on CPT and POBT were developed,namely TT-CPT and TT-POBT,respectively.Besides,TT-POBT possessed a smaller Stokes shift and a reduced reorganization energy compared with TT-CPT,indicating the introduction of S…O No CLs can enhance the molecular rigidity even if simplifying the molecular structure.As a result,the TT-POBT-based PSC device afforded an impressive power conversion efficiency of 11.15%,much higher than that of TT-CPT counterpart(7.03%),mainly resulting from the tighterπ-πstacking,improved and balanced charge transport,and more favorable film morphology.This work demonstrates the potential of the simple building block POBT with No CLs towards constructing low-cost and highperformance NFREAs.展开更多
Multifunctional alarm door locks developed and produced by the Shanghai Huxi Special Locks Factory are a product combining a safety lock with an alarm device and bell. All the technical data of the product have been e...Multifunctional alarm door locks developed and produced by the Shanghai Huxi Special Locks Factory are a product combining a safety lock with an alarm device and bell. All the technical data of the product have been examined and tested by the quality inspection展开更多
A comprehensive investigation was performed for repairing the different types of cracks appearing on the surface or inside the concrete lining at various depths.The mate- rial properties used in grouting and two metho...A comprehensive investigation was performed for repairing the different types of cracks appearing on the surface or inside the concrete lining at various depths.The mate- rial properties used in grouting and two methods for crack repair were discussed in details, and consequently reliable repair measures were proposed and implemented.It is a better choice to adopt the hole-drilling method for the relatively regular crack.The grouting pres- sure should not be too high and it is generally between 0.4～0.6 MPa.For the second time grouting,the pressure maybe increased to 0.8 MPa.Other method is the pasting nozzles method which is more suitable for irregular cracks such as cracks with intensive density and crossing cracks.Its grouting pressure is generally between 0.6～1.0 MPa.The in-situ tests in Three Gorges Project demonstrate favorably the feasibility and applicability of the proposed methods for crack repair within the lining concrete.展开更多
Permanent magnetic locks are a new high tech product manufactured by the Datang Industrial Corporation, Ltd. in the Jinan High Tech Development Zone. Instead of using mechanical springs, permanent magnetic locks featu...Permanent magnetic locks are a new high tech product manufactured by the Datang Industrial Corporation, Ltd. in the Jinan High Tech Development Zone. Instead of using mechanical springs, permanent magnetic locks feature alternating and equidifferent mono and multiple magnetic codes. The locks contain millions of codes. With no key hole or gears, permanent magnetic locks cannot be opened by a master key. The locks are damage proof, shock proof and drill proof, and easy to use. Permanent magnetic locks are used for safes, cars, motorcycles and bicycles.展开更多
Jindie (Golden Butterfly) Brand door locks are supergrade multifunctional locks developed by the Beijing City Building Locks Factory using imported advanced technology and equipment. Featuring security, reliability an...Jindie (Golden Butterfly) Brand door locks are supergrade multifunctional locks developed by the Beijing City Building Locks Factory using imported advanced technology and equipment. Featuring security, reliability and convenience, the products enjoy a good reputation in domestic and word markets. They include double, plug and ball-type locks, decorative locks and industrial locks. There are 36 varieties under five categories. The factory can also offer Jindie Brand electrical tools including hand and punch drills, automatic drills, rivet guns, electric scissors, stone cutting machines and diamond saw blades. The Beijing City Building Material Import and Export Corporation is sales agent for the products.展开更多
A lock solution composed of gentamicin sulfate(5 mg/mL) and ethylenediaminetetraacetic acid disodium salt(EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports...A lock solution composed of gentamicin sulfate(5 mg/mL) and ethylenediaminetetraacetic acid disodium salt(EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports(TIVAP). In this study, fabrication, conditioning and sterilization processes of antimicrobial lock solution(ALS) were detailed and completed by a stability study. Stability of ALS was conducted for12 months in vial(25 °C 7 2 °C, 60% 7 5% relative humidity(RH), and at 40 °C 7 2 °C, RH 75% 7 5%)and for 24 h and 72 h in TIVAP(40 °C 7 2 °C, RH 75% 7 5%). A stability indicating HPLC assay with UV detection for simultaneous quantification of gentamicin sulfate and EDTA-Na2 was developed. ALS was assayed by ion-pairing high performance liquid chromatography(HPLC) needing gentamicin derivatization, EDTA-Na2 metallocomplexation of samples and gradient mobile phase. HPLC methods to separate four gentamicin components and EDTA-Na2 were validated. Efficiency of sterility procedure and conditioning of ALS was confirmed by bacterial endotoxins and sterility tests. Physicochemical stability of ALS was determined by visual inspection, osmolality, pH, and sub-visible particle counting. Results confirmed that the stability of ALS in vials was maintained for 12 months and 24 h and 72 h in TIVAP.展开更多
Silt deposition occurs in the downstream approach channel of the tidal lock as in a closed channel or excavated dock basin. It is often difficult to calculate or predict siltation because of complex flow and sediment ...Silt deposition occurs in the downstream approach channel of the tidal lock as in a closed channel or excavated dock basin. It is often difficult to calculate or predict siltation because of complex flow and sediment conditions and many other affecting factors. In this paper, the characteristics of flow movement in the approach channel (including its mouth) of the tidal lock are analyzed, the basic laws of sediment movement and siltation mechanism are investigated, the conditions for three types of siltation (circumfluence siltation, density flow siltation and slow flow siltation) are discussed, and corresponding calculating formulas are proposed. A practical example shows that the difference between measured and calculated results is small, indicating that the present calculating methods could be used in design and management of practical engineering projects.展开更多
This paper introduces a multi-granularity locking model (MGL) for concurrency control in object-oriented database system briefiy, and presents a MGL model formally. Four lockingscheduling algorithms for MGL are propos...This paper introduces a multi-granularity locking model (MGL) for concurrency control in object-oriented database system briefiy, and presents a MGL model formally. Four lockingscheduling algorithms for MGL are proposed in the paper. The ideas of single queue scheduling(SQS) and dual queue scheduling (DQS) are proposed and the algorithm and the performance evaluation for these two scheduling are presented in some paper. This paper describes a new idea of thescheduling for MGL, compatible requests first (CRF). Combining the new idea with SQS and DQS,we propose two new scheduling algorithms called CRFS and CRFD. After describing the simulationmodel, this paper illustrates the comparisons of the performance among these four algorithms. Asshown in the experiments, DQS has better performance than SQS, CRFD is better than DQS, CRFSperforms better than SQS, and CRFS is the best one of these four scheduling algorithms.展开更多
A flexible polydentate bis(amidine)ligand LH_(2),LH_(2)={CH_(2)NH(tBu)CvN-2-(6-MePy)}_(2),operates as a molecular lock for various coinage metal fragments and forms the dinuclear complexes[LH_(2)(MCl)_(2)],M=Cu(1),Au(...A flexible polydentate bis(amidine)ligand LH_(2),LH_(2)={CH_(2)NH(tBu)CvN-2-(6-MePy)}_(2),operates as a molecular lock for various coinage metal fragments and forms the dinuclear complexes[LH_(2)(MCl)_(2)],M=Cu(1),Au(2),the coordination polymer[{(LH_(2))_(2)(py)_(2)(AgCl)_(3)}(py)_(3)]_(n)(3),and the dimesityl-digold complex[LH_(2)(AuMes)_(2)](4)by formal insertion of MR fragments(M=Cu,Ag,Au;R=Cl,Mes)into the N–H⋯N hydrogen bonds of LH_(2)in yields of 43–95%.Complexes 1,2,and 4 adopt C_(2)-symmetrical structures in the solid state featuring two interconnected 11-membered rings that are locked by two intramolecular N–H⋯R–M hydrogen bonds.QTAIM analyses of the computational geometry-optimized structures 1a,2a,and 4a reveal 13,11,and 22 additional bond critical points,respectively,all of which are related to weak intramolecular attractive interactions,predominantly representing dispersion forces,contributing to the conformational stabilization of the C_(2)-symmetrical stereoisomers in the solid state.Variable-temperature ^(1)H NMR spectroscopy in combination with DFT calculations indicate a dynamic conformational interconversion between two C_(2)-symmetrical ground state structures in solution(ΔG_(c)^(‡)=11.1–13.8 kcal mol^(-1)),which is accompanied by the formation of an intermediate possessing Cᵢsymmetry that retains the hydrogen bonds.展开更多
Highly planar conformation is considered to be one of the most important properties for high performance organic semiconductors. Among all kinds strategies for designing highly performing materials, noncovalent confor...Highly planar conformation is considered to be one of the most important properties for high performance organic semiconductors. Among all kinds strategies for designing highly performing materials, noncovalent conformational locks （NCLs） have been widely used to increase the planarity and rigidity for x-conjugated systems. This review summarizes π-conjugated small molecules and polymers by employing various NCLs for controlling molecular conformation in the past two years. The optoelectronic properties of the conjugated materials, together with their applications on organic field-effect transistors （OFETs） and organic photovoltaics （OPVs） are discussed. Besides, the outlook and challenges in this field are also presented. It is obvious that NCLs play an important role in the design and synthesis of high-performance organic semiconductors.展开更多
Comprehensive Summary By employing thiazole and 4-chlorothiazole as the A′units,two A-D-A′-D-A type nonfused-ring electron acceptors(NFREAs)Tz-H and Tz-Cl were designed and synthesized.Replacing thiazole in Tz-H wit...Comprehensive Summary By employing thiazole and 4-chlorothiazole as the A′units,two A-D-A′-D-A type nonfused-ring electron acceptors(NFREAs)Tz-H and Tz-Cl were designed and synthesized.Replacing thiazole in Tz-H with 4-chlorothiazole can not only remarkably shorten the synthetic route through C—H direct arylation but also enhance molecular planarity with the simultaneous incorporation of S…N and S…Cl noncovalently conformational locks(NoCLs).The photovoltaic devices based on PM6:Tz-Cl exhibited a power conversion efficiency as high as 11.10%,much higher than that of PM6:Tz-H(6.41%),mainly due to more efficient exciton dissociation,better and more balanced carrier mobility,less charge recombination,and more favorable morphology.These findings demonstrate the great potential of NoCLs in achieving low-cost and high-performance NFREAs.展开更多
Highly matched and precisely locked to the absorption lines of rubidium(Rb)atoms,780 nm lasers play a crucial role in fields such as quantum computing,precision measurements,and high-sensitivity sensing,with clear req...Highly matched and precisely locked to the absorption lines of rubidium(Rb)atoms,780 nm lasers play a crucial role in fields such as quantum computing,precision measurements,and high-sensitivity sensing,with clear requirements for strong coherence and fast tunability.In this paper,based on the self-injection locking and ultra-high quality factor whispering gallery mode(WGM)cavity,a 780 nm narrow linewidth(23.8 kHz)tunable laser with a single longitudinal mode output is verified.More importantly,benefiting from the optimized combined coupling coefficient K and via the lithium niobate electro-optic effect,the laser frequency detuning is ef⁃fectively improved,with the experimental tuning range reaching 110 pm and the tuning efficiency of 6.4 pm/V.This work provides a high-performance design solution for fast-tunable narrow-linewidth lasers for applications in the near-infrared range,which is expected to play an essential role in the future.展开更多
By employing the asymmetric end-group engineering,an asymmetric nonfused-ring electron acceptor(NFREA)was designed and synthesized.Compared with the symmetric analogs(NoCA-17 and NoCA-18),NoCA-19 possesses broader lig...By employing the asymmetric end-group engineering,an asymmetric nonfused-ring electron acceptor(NFREA)was designed and synthesized.Compared with the symmetric analogs(NoCA-17 and NoCA-18),NoCA-19 possesses broader light absorption range,more coplanarπ-conjugated backbone,and appropriate crystallinity according to the experimental and theoretical results.The organic solar cells based on J52:NoCA-19 exhibited a power conversion efficiency as high as 12.26%,which is much higher than those of J52:NoCA-17(9.50%)and J52:NoCA-18(11.77%),mainly due to more efficient exciton dissociation,better and balanced charge mobility,suppressed recombination loss,shorter charge extraction time,longer charge carrier lifetimes,and more favorable blend film morphology.These findings demonstrate the great potential of asymmetric end-group engineering in exploring low-cost and high-performance NFREAs.展开更多
Yogyakarta was struck by a devastating Mw6.3 earthquake,which intensified awareness about the seismic hazards in the region.This study investigates the kinematic slip rate and seismogenic depth of the northern segment...Yogyakarta was struck by a devastating Mw6.3 earthquake,which intensified awareness about the seismic hazards in the region.This study investigates the kinematic slip rate and seismogenic depth of the northern segment of Opak Fault and an unmapped fault known as Ngalang Fault in Yogyakarta,utilizing Global Navigation Satellite System(GNSS)data collected between 2019 and 2023.By deploying a network of 12 GNSS stations alongside continuous observations from the InaCORS network,we perfo rmed a detailed geodetic analysis to discern current defo rmation patterns.To quantify the slip rate,we established a frame of reference using the Sundaland Block's rotational parameters and applied the Euler pole angular velocity to transform daily GNSS solutions acco rdingly.The findings reveal significant left-lateral strike-slip motion in the northern segment of Opak Fault,with a slip rate averaging 3 mm/yr and a locking depth of 2.1 km in Northern Segment,whereas the slip rate averages 1.1 mm/yr and the locking depth is estimated at 1 km in the Ngalang Fault,indicating active geological movements that may influence future seismicity.展开更多
Conventional locking/release mechanisms often face challenges in aircraft wing separation processes,such as excessive impact loads and insufficient synchronization.These may cause structural damage to the airframe or ...Conventional locking/release mechanisms often face challenges in aircraft wing separation processes,such as excessive impact loads and insufficient synchronization.These may cause structural damage to the airframe or attitude instability,seriously compromising mission reliability.To address this engineering challenge,this paper proposes a multi-point low-impact locking/release mechanism based on the mobility model and energy conversion strategy.Through establishing a DOF constraint framework system,this paper systematically analyzes the energy transfer and conversion characteristics during the wing separation process,reveals the generation mechanism of impact loads,and conducts research on low-impact design based on energy conversion strategy.Building on this foundation,a single-point locking/release mechanism employing parallel trapezoidal key shaft structure was designed,which increases frictional contact time and reduces the energy release rate,thereby achieving low-impact characteristics.The mechanism's performance was validated through physical prototype development and systematic functional testing(including unlocking force,synchronization,and impact tests).Experimental results demonstrate:(1)Under 14 kN preload condition,the maximum unlocking force was only 92.54 N,showing a linear relationship with preload that satisfies the"strong-connection/weak-unlock"design requirement;(2)Wing separation was completed within 46 ms,with synchronization time difference among three separation mechanisms stably controlled within 12-14 ms,proving rapid and reliable operation;(3)The unlocking impact acceleration ranged between 26 and 73 g,below the 100 g design limit,confirming the effectiveness of the energy conversion strategy.The proposed low-impact locking/release mechanism design method based on energy conversion strategy resolves the traditional challenges of high impact and synchronization deficiencies.The synergistic optimization mechanism of"structural load reduction and performance improvement"provides a highly reliable technical solution for wing separable mechanisms while offering novel design insights for wing connection/separation systems engineering.展开更多
Hypersonic morphing vehicle(HMV)can reconfigure aerodynamic geometries in real time,adapting to diverse needs like multi-mission profiles and wide-speed-range flight,spanwise morphing and sweep angle variation are rep...Hypersonic morphing vehicle(HMV)can reconfigure aerodynamic geometries in real time,adapting to diverse needs like multi-mission profiles and wide-speed-range flight,spanwise morphing and sweep angle variation are representative large-scale wing reconfiguration modes.To meet the HMV's need for an increased lift and a lift to drag ratio during hypersonic maneuverability and cruise or reentry equilibrium glide,this paper proposes an innovative single-DOF coupled morphing-wing system.We then systematically analyze its open-loop kinematics and closed-loop connectivity constraints,and the proposed system integrates three functional modules:the preset locking/release mechanism,the coupled morphing-wing mechanism,and the integrated wing locking with active stiffness control mechanism.Experimental validation confirms stable,continuous morphing under simulated aerodynamic loads.The experimental results indicate:(i)SMA actuators exhibit response times ranging from 18 s to 160 s,providing sufficient force output for wing unlocking;(ii)The integrated wing locking with active stiffness control mechanism effectively secures wing positions while eliminating airframe clearance via SMA actuation,improving the first-order natural frequency by more than 17%;(iii)The distributed aerodynamic loading system enables precise multi-stage follow-up loading during morphing,with the coupled morphing wing maintaining stable,continuous operation under 0-3500 N normal loads and 110-140 N axial force.The proposed single-DOF coupled morphing mechanism not only simplifies and improves structural efficiency but also demonstrates superior performance in locking control,stiffness enhancement,and aerodynamic responsiveness.This establishes a foundational framework for the design of future intelligent morphing configurations and the implementation of flight control systems.展开更多
In this work,the Hierarchical Quadrature Element Method(HQEM)formulation of geometrically exact shells is proposed and applied for geometrically nonlinear analyses of both isotropic and laminated shells.The stress res...In this work,the Hierarchical Quadrature Element Method(HQEM)formulation of geometrically exact shells is proposed and applied for geometrically nonlinear analyses of both isotropic and laminated shells.The stress resultant formulation is developed within the HQEM framework,consequently significantly simplifying the computations of residual force and stiffness matrix.The present formulation inherently avoids shear and membrane locking,benefiting from its high-order approximation property.Furthermore,HQEM’s independent nodal distribution capability conveniently supports local p-refinement and flexibly facilitates mesh generation in various structural configurations through the combination of quadrilateral and triangular elements.Remarkably,in lateral buckling analysis,the HQEM outperforms the weak-form quadrilateral element(QEM)in accuracy with identical nodal degrees of freedom(three displacements and two rotations).Under high-load nonlinear response,the QEM exhibits a maximum relative deviation of approximately 9.5%from the reference,while the HQEM remains closely aligned with the benchmark results.In addition,for the cantilever beam under tip moment,HQEM produces virtually no out-of-plane deviation,compared to a slight deviation of 0.00001 with QEM,confirming its superior numerical reliability.In summary,the method demonstrates high accuracy,superior convergence,and robustness in handling large rotations and complex post-buckling behaviors across a series of benchmark problems.展开更多
Synchronous reluctance motors(SynRM)are widely employed in industrial applications due to their high robustness,low cost,and absence of permanent magnets.In recent years,significant research efforts have focused on im...Synchronous reluctance motors(SynRM)are widely employed in industrial applications due to their high robustness,low cost,and absence of permanent magnets.In recent years,significant research efforts have focused on improving the controllability and efficiency of SynRM.Accurate rotor position information is essential for the controller to generate appropriate current and voltage references corresponding to the desired speed and load torque.Shaft-mounted position sensors are generally undesirable because of their high cost,sensitivity to harsh operating conditions,maintenance requirements,and reduced reliability in environments characterized by high vibration.Consequently,sensorless control techniques that estimate rotor position using measured stator currents and voltages have attracted increasing attention.However,magnetic saturation,parameter nonlinearities,and cross-coupling effects significantly degrade position estimation accuracy and may compromise the stability of sensorless SynRM drives.In this paper,a nonlinear SynRM model is developed using finite element analysis(FEA)to accurately capture magnetic saturation and cross-coupling effects,thereby providing a precise representation of the machine’s electromagnetic behavior under varying load and flux conditions.A series of magnetostatic FEA simulations is performed.To reduce computational complexity,only one motor pole is analyzed by applying anti-periodic boundary conditions along the domain sides and enforcing a zero magnetic vector potential on the external stator boundary.Nonlinear iron material properties are modeled using the appropriate B-H curve.The simulations are carried out by imposing d-and q-axis current components and computing the corresponding flux linkages and electromagnetic torque.Based on these results,both apparent and incremental inductances are extracted and incorporated into the control algorithm.An advanced fictitious flux linkage method combined with a phase-locked loop(PLL)is employed for accurate rotor position estimation.Simulation results confirm that the proposed sensorless control strategy ensures stable operation and high position estimation accuracy over the entire speed range.展开更多
Zhang Yan's neighborhood in central Beijing is a safe one—at least that was what she thought when she went to bed as usual one evening,leaving her front door unlocked.
基金the National Natural Science Foundation of China(Nos.52103352,51925306 and 52120105006)National Key R&D Program of China(No.2018FYA 0305800)+3 种基金Key Research Program of Chinese Academy of Sciences(No.XDPB08-2)the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB28000000)the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2022165)the Fundamental Research Funds for the Central Universities.
文摘Nonfused ring electron acceptors(NFREAs)have attracted much attention due to their concise synthetic routes and low cost.However,developing high-performance NFREAs with simple structure remains a great challenge.In this work,a simple building block(POBT)with noncovalently conformational locks(No CLs)was designed and synthesized.Single-crystal X-ray study indicated the presence of S…O NOCLs in POBT,thus enabling it to possess a coplanar conformation comparable to that of fused-ring CPT.Two novel NFREAs based on CPT and POBT were developed,namely TT-CPT and TT-POBT,respectively.Besides,TT-POBT possessed a smaller Stokes shift and a reduced reorganization energy compared with TT-CPT,indicating the introduction of S…O No CLs can enhance the molecular rigidity even if simplifying the molecular structure.As a result,the TT-POBT-based PSC device afforded an impressive power conversion efficiency of 11.15%,much higher than that of TT-CPT counterpart(7.03%),mainly resulting from the tighterπ-πstacking,improved and balanced charge transport,and more favorable film morphology.This work demonstrates the potential of the simple building block POBT with No CLs towards constructing low-cost and highperformance NFREAs.
文摘Multifunctional alarm door locks developed and produced by the Shanghai Huxi Special Locks Factory are a product combining a safety lock with an alarm device and bell. All the technical data of the product have been examined and tested by the quality inspection
基金the National Natural Science Foundation of China(10602049)
文摘A comprehensive investigation was performed for repairing the different types of cracks appearing on the surface or inside the concrete lining at various depths.The mate- rial properties used in grouting and two methods for crack repair were discussed in details, and consequently reliable repair measures were proposed and implemented.It is a better choice to adopt the hole-drilling method for the relatively regular crack.The grouting pres- sure should not be too high and it is generally between 0.4～0.6 MPa.For the second time grouting,the pressure maybe increased to 0.8 MPa.Other method is the pasting nozzles method which is more suitable for irregular cracks such as cracks with intensive density and crossing cracks.Its grouting pressure is generally between 0.6～1.0 MPa.The in-situ tests in Three Gorges Project demonstrate favorably the feasibility and applicability of the proposed methods for crack repair within the lining concrete.
文摘Permanent magnetic locks are a new high tech product manufactured by the Datang Industrial Corporation, Ltd. in the Jinan High Tech Development Zone. Instead of using mechanical springs, permanent magnetic locks feature alternating and equidifferent mono and multiple magnetic codes. The locks contain millions of codes. With no key hole or gears, permanent magnetic locks cannot be opened by a master key. The locks are damage proof, shock proof and drill proof, and easy to use. Permanent magnetic locks are used for safes, cars, motorcycles and bicycles.
文摘Jindie (Golden Butterfly) Brand door locks are supergrade multifunctional locks developed by the Beijing City Building Locks Factory using imported advanced technology and equipment. Featuring security, reliability and convenience, the products enjoy a good reputation in domestic and word markets. They include double, plug and ball-type locks, decorative locks and industrial locks. There are 36 varieties under five categories. The factory can also offer Jindie Brand electrical tools including hand and punch drills, automatic drills, rivet guns, electric scissors, stone cutting machines and diamond saw blades. The Beijing City Building Material Import and Export Corporation is sales agent for the products.
基金supported by Centre de Recherche Translationnelle de I'Institut Pasteur, grant Number S- PI15007-02Asupported by the French Government's Investissement d'Avenir program:Laboratoire d'Excellence ‘Integrative Biology of Emerging Infectious Diseases’ (grant no. ANR-10-LABX62-IBEID.)+1 种基金the Fondation pour la Recherche Médicale (grant no. DEQ. 20140329508)the Center for Translational Science of the Institut Pasteur (S-PI15007-02A)
文摘A lock solution composed of gentamicin sulfate(5 mg/mL) and ethylenediaminetetraacetic acid disodium salt(EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports(TIVAP). In this study, fabrication, conditioning and sterilization processes of antimicrobial lock solution(ALS) were detailed and completed by a stability study. Stability of ALS was conducted for12 months in vial(25 °C 7 2 °C, 60% 7 5% relative humidity(RH), and at 40 °C 7 2 °C, RH 75% 7 5%)and for 24 h and 72 h in TIVAP(40 °C 7 2 °C, RH 75% 7 5%). A stability indicating HPLC assay with UV detection for simultaneous quantification of gentamicin sulfate and EDTA-Na2 was developed. ALS was assayed by ion-pairing high performance liquid chromatography(HPLC) needing gentamicin derivatization, EDTA-Na2 metallocomplexation of samples and gradient mobile phase. HPLC methods to separate four gentamicin components and EDTA-Na2 were validated. Efficiency of sterility procedure and conditioning of ALS was confirmed by bacterial endotoxins and sterility tests. Physicochemical stability of ALS was determined by visual inspection, osmolality, pH, and sub-visible particle counting. Results confirmed that the stability of ALS in vials was maintained for 12 months and 24 h and 72 h in TIVAP.
文摘Silt deposition occurs in the downstream approach channel of the tidal lock as in a closed channel or excavated dock basin. It is often difficult to calculate or predict siltation because of complex flow and sediment conditions and many other affecting factors. In this paper, the characteristics of flow movement in the approach channel (including its mouth) of the tidal lock are analyzed, the basic laws of sediment movement and siltation mechanism are investigated, the conditions for three types of siltation (circumfluence siltation, density flow siltation and slow flow siltation) are discussed, and corresponding calculating formulas are proposed. A practical example shows that the difference between measured and calculated results is small, indicating that the present calculating methods could be used in design and management of practical engineering projects.
文摘This paper introduces a multi-granularity locking model (MGL) for concurrency control in object-oriented database system briefiy, and presents a MGL model formally. Four lockingscheduling algorithms for MGL are proposed in the paper. The ideas of single queue scheduling(SQS) and dual queue scheduling (DQS) are proposed and the algorithm and the performance evaluation for these two scheduling are presented in some paper. This paper describes a new idea of thescheduling for MGL, compatible requests first (CRF). Combining the new idea with SQS and DQS,we propose two new scheduling algorithms called CRFS and CRFD. After describing the simulationmodel, this paper illustrates the comparisons of the performance among these four algorithms. Asshown in the experiments, DQS has better performance than SQS, CRFD is better than DQS, CRFSperforms better than SQS, and CRFS is the best one of these four scheduling algorithms.
基金supported by the U.S.Department of Energy,Office of Energy Sciences Materials Sciences Division,under contract DE-AC02-05CH11231support for providing computing resources by the Advanced Computer Services at Kennesaw State University+1 种基金support by the Department of Chemistry and Biochemistry(New Faculty Startup Fund(#08020)as well as the College of Sciences and Mathematics(CSM)at Kennesaw State University(CSM Research Stimulus Program)by Aditya Birla Carbon(Birla Carbon Scholarship for O.U.T.)is acknowledged.This material is based upon work supported by the US National Science Foundation under grant CHE-1800332.
文摘A flexible polydentate bis(amidine)ligand LH_(2),LH_(2)={CH_(2)NH(tBu)CvN-2-(6-MePy)}_(2),operates as a molecular lock for various coinage metal fragments and forms the dinuclear complexes[LH_(2)(MCl)_(2)],M=Cu(1),Au(2),the coordination polymer[{(LH_(2))_(2)(py)_(2)(AgCl)_(3)}(py)_(3)]_(n)(3),and the dimesityl-digold complex[LH_(2)(AuMes)_(2)](4)by formal insertion of MR fragments(M=Cu,Ag,Au;R=Cl,Mes)into the N–H⋯N hydrogen bonds of LH_(2)in yields of 43–95%.Complexes 1,2,and 4 adopt C_(2)-symmetrical structures in the solid state featuring two interconnected 11-membered rings that are locked by two intramolecular N–H⋯R–M hydrogen bonds.QTAIM analyses of the computational geometry-optimized structures 1a,2a,and 4a reveal 13,11,and 22 additional bond critical points,respectively,all of which are related to weak intramolecular attractive interactions,predominantly representing dispersion forces,contributing to the conformational stabilization of the C_(2)-symmetrical stereoisomers in the solid state.Variable-temperature ^(1)H NMR spectroscopy in combination with DFT calculations indicate a dynamic conformational interconversion between two C_(2)-symmetrical ground state structures in solution(ΔG_(c)^(‡)=11.1–13.8 kcal mol^(-1)),which is accompanied by the formation of an intermediate possessing Cᵢsymmetry that retains the hydrogen bonds.
基金supported by the National Natural Science Foundation of China (21774130, 21574135)Beijing Municipal Natural Science Foundation (2162043)+2 种基金the Key Research Program of Frontier Science, Chinese Academy of Sciences (QYZDB-SSW-JSC046)Key Research Program of the Chinese Academy of Sciences (XDPB08-2)One Hundred Talents Program of Chinese Academy of Sciences, and University of Chinese Academy of Sciences
文摘Highly planar conformation is considered to be one of the most important properties for high performance organic semiconductors. Among all kinds strategies for designing highly performing materials, noncovalent conformational locks （NCLs） have been widely used to increase the planarity and rigidity for x-conjugated systems. This review summarizes π-conjugated small molecules and polymers by employing various NCLs for controlling molecular conformation in the past two years. The optoelectronic properties of the conjugated materials, together with their applications on organic field-effect transistors （OFETs） and organic photovoltaics （OPVs） are discussed. Besides, the outlook and challenges in this field are also presented. It is obvious that NCLs play an important role in the design and synthesis of high-performance organic semiconductors.
基金the National Natural Science Foundation of China((52120105006,52103352,and 51925306)National Key R&D Program of China(2018FYA 0305800)+3 种基金Key Research Program of Chinese Academy of Sciences(XDPB08-2)the Strategic Priority Research Program of Chinese Academy of Sciences(XDB28000000)the Youth Innovation Promotion Association of Chinese Academy of Sciences(2022165)the Fundamental Research Funds for the Central Universities.DFT results described in this report were obtained from the National Supercomputing Center in Shenzhen(Shenzhen CloudComputing Center).
文摘Comprehensive Summary By employing thiazole and 4-chlorothiazole as the A′units,two A-D-A′-D-A type nonfused-ring electron acceptors(NFREAs)Tz-H and Tz-Cl were designed and synthesized.Replacing thiazole in Tz-H with 4-chlorothiazole can not only remarkably shorten the synthetic route through C—H direct arylation but also enhance molecular planarity with the simultaneous incorporation of S…N and S…Cl noncovalently conformational locks(NoCLs).The photovoltaic devices based on PM6:Tz-Cl exhibited a power conversion efficiency as high as 11.10%,much higher than that of PM6:Tz-H(6.41%),mainly due to more efficient exciton dissociation,better and more balanced carrier mobility,less charge recombination,and more favorable morphology.These findings demonstrate the great potential of NoCLs in achieving low-cost and high-performance NFREAs.
基金Supported by the General Program of National Natural Science Foundation of China(62373331)the Joint Funds of the National Natural Science Foundation of China(U21A20141)+1 种基金the Innovative Research Group Project of the National Natural Science Foundation of China(51821003)the Natural Science Foundation of Shanxi Province(202403021211095).
文摘Highly matched and precisely locked to the absorption lines of rubidium(Rb)atoms,780 nm lasers play a crucial role in fields such as quantum computing,precision measurements,and high-sensitivity sensing,with clear requirements for strong coherence and fast tunability.In this paper,based on the self-injection locking and ultra-high quality factor whispering gallery mode(WGM)cavity,a 780 nm narrow linewidth(23.8 kHz)tunable laser with a single longitudinal mode output is verified.More importantly,benefiting from the optimized combined coupling coefficient K and via the lithium niobate electro-optic effect,the laser frequency detuning is ef⁃fectively improved,with the experimental tuning range reaching 110 pm and the tuning efficiency of 6.4 pm/V.This work provides a high-performance design solution for fast-tunable narrow-linewidth lasers for applications in the near-infrared range,which is expected to play an essential role in the future.
基金the financial support fromtheNSFC(21975055,U2001222,52103352,52120105006,and 51925306)National Key R&D Program of China(2018FYA 0305800)+2 种基金Key Research Program of Chinese Academy of Sciences(XDPB08-2)the Youth Innovation Promotion Association of Chinese Academy of Sciences(2022165)the Fundamental Research Funds for the Central Universities.DFT results described in this article were obtained from the National Supercomputing Centre in Shenzhen(Shenzhen Cloud Computing Centre).
文摘By employing the asymmetric end-group engineering,an asymmetric nonfused-ring electron acceptor(NFREA)was designed and synthesized.Compared with the symmetric analogs(NoCA-17 and NoCA-18),NoCA-19 possesses broader light absorption range,more coplanarπ-conjugated backbone,and appropriate crystallinity according to the experimental and theoretical results.The organic solar cells based on J52:NoCA-19 exhibited a power conversion efficiency as high as 12.26%,which is much higher than those of J52:NoCA-17(9.50%)and J52:NoCA-18(11.77%),mainly due to more efficient exciton dissociation,better and balanced charge mobility,suppressed recombination loss,shorter charge extraction time,longer charge carrier lifetimes,and more favorable blend film morphology.These findings demonstrate the great potential of asymmetric end-group engineering in exploring low-cost and high-performance NFREAs.
基金funded by the Department of Geodetic Engineering,Faculty of Engineering,Universitas Gadjah Mada。
文摘Yogyakarta was struck by a devastating Mw6.3 earthquake,which intensified awareness about the seismic hazards in the region.This study investigates the kinematic slip rate and seismogenic depth of the northern segment of Opak Fault and an unmapped fault known as Ngalang Fault in Yogyakarta,utilizing Global Navigation Satellite System(GNSS)data collected between 2019 and 2023.By deploying a network of 12 GNSS stations alongside continuous observations from the InaCORS network,we perfo rmed a detailed geodetic analysis to discern current defo rmation patterns.To quantify the slip rate,we established a frame of reference using the Sundaland Block's rotational parameters and applied the Euler pole angular velocity to transform daily GNSS solutions acco rdingly.The findings reveal significant left-lateral strike-slip motion in the northern segment of Opak Fault,with a slip rate averaging 3 mm/yr and a locking depth of 2.1 km in Northern Segment,whereas the slip rate averages 1.1 mm/yr and the locking depth is estimated at 1 km in the Ngalang Fault,indicating active geological movements that may influence future seismicity.
文摘Conventional locking/release mechanisms often face challenges in aircraft wing separation processes,such as excessive impact loads and insufficient synchronization.These may cause structural damage to the airframe or attitude instability,seriously compromising mission reliability.To address this engineering challenge,this paper proposes a multi-point low-impact locking/release mechanism based on the mobility model and energy conversion strategy.Through establishing a DOF constraint framework system,this paper systematically analyzes the energy transfer and conversion characteristics during the wing separation process,reveals the generation mechanism of impact loads,and conducts research on low-impact design based on energy conversion strategy.Building on this foundation,a single-point locking/release mechanism employing parallel trapezoidal key shaft structure was designed,which increases frictional contact time and reduces the energy release rate,thereby achieving low-impact characteristics.The mechanism's performance was validated through physical prototype development and systematic functional testing(including unlocking force,synchronization,and impact tests).Experimental results demonstrate:(1)Under 14 kN preload condition,the maximum unlocking force was only 92.54 N,showing a linear relationship with preload that satisfies the"strong-connection/weak-unlock"design requirement;(2)Wing separation was completed within 46 ms,with synchronization time difference among three separation mechanisms stably controlled within 12-14 ms,proving rapid and reliable operation;(3)The unlocking impact acceleration ranged between 26 and 73 g,below the 100 g design limit,confirming the effectiveness of the energy conversion strategy.The proposed low-impact locking/release mechanism design method based on energy conversion strategy resolves the traditional challenges of high impact and synchronization deficiencies.The synergistic optimization mechanism of"structural load reduction and performance improvement"provides a highly reliable technical solution for wing separable mechanisms while offering novel design insights for wing connection/separation systems engineering.
基金supported by the National Natural Science Foundation of China(Grant No.52405257)the China Postdoctoral Science Foundation(Grant No.2024M764201).
文摘Hypersonic morphing vehicle(HMV)can reconfigure aerodynamic geometries in real time,adapting to diverse needs like multi-mission profiles and wide-speed-range flight,spanwise morphing and sweep angle variation are representative large-scale wing reconfiguration modes.To meet the HMV's need for an increased lift and a lift to drag ratio during hypersonic maneuverability and cruise or reentry equilibrium glide,this paper proposes an innovative single-DOF coupled morphing-wing system.We then systematically analyze its open-loop kinematics and closed-loop connectivity constraints,and the proposed system integrates three functional modules:the preset locking/release mechanism,the coupled morphing-wing mechanism,and the integrated wing locking with active stiffness control mechanism.Experimental validation confirms stable,continuous morphing under simulated aerodynamic loads.The experimental results indicate:(i)SMA actuators exhibit response times ranging from 18 s to 160 s,providing sufficient force output for wing unlocking;(ii)The integrated wing locking with active stiffness control mechanism effectively secures wing positions while eliminating airframe clearance via SMA actuation,improving the first-order natural frequency by more than 17%;(iii)The distributed aerodynamic loading system enables precise multi-stage follow-up loading during morphing,with the coupled morphing wing maintaining stable,continuous operation under 0-3500 N normal loads and 110-140 N axial force.The proposed single-DOF coupled morphing mechanism not only simplifies and improves structural efficiency but also demonstrates superior performance in locking control,stiffness enhancement,and aerodynamic responsiveness.This establishes a foundational framework for the design of future intelligent morphing configurations and the implementation of flight control systems.
基金supported by the National Natural Science Foundation of China(Grant Nos.12472194,12002018,11972004,11772031,11402015).
文摘In this work,the Hierarchical Quadrature Element Method(HQEM)formulation of geometrically exact shells is proposed and applied for geometrically nonlinear analyses of both isotropic and laminated shells.The stress resultant formulation is developed within the HQEM framework,consequently significantly simplifying the computations of residual force and stiffness matrix.The present formulation inherently avoids shear and membrane locking,benefiting from its high-order approximation property.Furthermore,HQEM’s independent nodal distribution capability conveniently supports local p-refinement and flexibly facilitates mesh generation in various structural configurations through the combination of quadrilateral and triangular elements.Remarkably,in lateral buckling analysis,the HQEM outperforms the weak-form quadrilateral element(QEM)in accuracy with identical nodal degrees of freedom(three displacements and two rotations).Under high-load nonlinear response,the QEM exhibits a maximum relative deviation of approximately 9.5%from the reference,while the HQEM remains closely aligned with the benchmark results.In addition,for the cantilever beam under tip moment,HQEM produces virtually no out-of-plane deviation,compared to a slight deviation of 0.00001 with QEM,confirming its superior numerical reliability.In summary,the method demonstrates high accuracy,superior convergence,and robustness in handling large rotations and complex post-buckling behaviors across a series of benchmark problems.
文摘Synchronous reluctance motors(SynRM)are widely employed in industrial applications due to their high robustness,low cost,and absence of permanent magnets.In recent years,significant research efforts have focused on improving the controllability and efficiency of SynRM.Accurate rotor position information is essential for the controller to generate appropriate current and voltage references corresponding to the desired speed and load torque.Shaft-mounted position sensors are generally undesirable because of their high cost,sensitivity to harsh operating conditions,maintenance requirements,and reduced reliability in environments characterized by high vibration.Consequently,sensorless control techniques that estimate rotor position using measured stator currents and voltages have attracted increasing attention.However,magnetic saturation,parameter nonlinearities,and cross-coupling effects significantly degrade position estimation accuracy and may compromise the stability of sensorless SynRM drives.In this paper,a nonlinear SynRM model is developed using finite element analysis(FEA)to accurately capture magnetic saturation and cross-coupling effects,thereby providing a precise representation of the machine’s electromagnetic behavior under varying load and flux conditions.A series of magnetostatic FEA simulations is performed.To reduce computational complexity,only one motor pole is analyzed by applying anti-periodic boundary conditions along the domain sides and enforcing a zero magnetic vector potential on the external stator boundary.Nonlinear iron material properties are modeled using the appropriate B-H curve.The simulations are carried out by imposing d-and q-axis current components and computing the corresponding flux linkages and electromagnetic torque.Based on these results,both apparent and incremental inductances are extracted and incorporated into the control algorithm.An advanced fictitious flux linkage method combined with a phase-locked loop(PLL)is employed for accurate rotor position estimation.Simulation results confirm that the proposed sensorless control strategy ensures stable operation and high position estimation accuracy over the entire speed range.
文摘Zhang Yan's neighborhood in central Beijing is a safe one—at least that was what she thought when she went to bed as usual one evening,leaving her front door unlocked.
