Hydatid disease,caused by the Echinococcus granulosus parasite,is traditionally associated with liver and lung involvement.However,recent years have seen an increase in cases with atypical localizations,such as the ki...Hydatid disease,caused by the Echinococcus granulosus parasite,is traditionally associated with liver and lung involvement.However,recent years have seen an increase in cases with atypical localizations,such as the kidneys,thyroid,soft tissues,and bones.The study by Celik et al presents a series of five clinical cases where hydatid cysts were found in these rare anatomical regions,challenging conventional diagnostic and therapeutic approaches.The paper emphasizes the importance of differential diagnosis,as these cases can mimic other conditions,such as cancer,abscesses,or cysts.Advanced imaging techniques,such as com-puted tomography,magnetic resonance imaging,and ultrasound,play a crucial role in accurate diagnosis and help avoid misdiagnosis.The study demonstrates that early diagnosis and appropriate treatment of echinococosis in atypical localiz-ations are critical for preventing complications like cyst rupture and secondary infections.The use of albendazole and surgical intervention,especially in combi-nation with modern imaging techniques,yields good outcomes in these patients.However,several unanswered questions remain:What are the precise criteria for selecting the optimal treatment method in each case?What is the long-term effect-iveness of different approaches?Do patients with hydatid cysts in atypical lo-cations require additional monitoring and preventive treatment to avoid recu-rrence?Addressing these questions requires further research,and a multidisci-plinary approach involving radiologists,surgeons,and infectious disease spe-cialists is essential to optimize diagnosis and treatment.Early and accurate diagnostic methods based on differential diagnosis play a key role in improving treatment outcomes and reducing morbidity.展开更多
BACKGROUND Hydatid cyst disease,caused by Echinococcus granulosus,primarily affects the liver and lungs,but it can also develop in rare locations such as the kidneys,thyroid,subcutaneous tissues,bones,and the mediasti...BACKGROUND Hydatid cyst disease,caused by Echinococcus granulosus,primarily affects the liver and lungs,but it can also develop in rare locations such as the kidneys,thyroid,subcutaneous tissues,bones,and the mediastinum.These atypical presentations often pose diagnostic challenges,as they can mimic benign and malignant pathologies,leading to potential misdiagnoses and inappropriate treatments.Early and accurate detection of hydatid cysts in uncommon sites is crucial for optimal patient management.CASE SUMMARY This case report series presents five patients with hydatid cysts located in atypical anatomical regions:The kidney,lumbar subcutaneous tissue,gluteal soft tissue,posterior mediastinum,and thyroid gland.The patients exhibited diverse clinical symptoms,including hematuria,palpable masses,localized pain,and chronic cough.Diagnosis was confirmed through a combination of imaging techniquesultrasound,computed tomography,and magnetic resonance imaging-along with serological testing.All cases were managed with antiparasitic therapy(albendazole),and in selected cases,surgical excision was performed to prevent complications such as cyst rupture or secondary infections.Post-treatment follow-up demonstrated complete resolution or stable cystic lesions,with no signs of recurrence.CONCLUSION Recognizing hydatid cysts in atypical locations is essential to avoid misdiagnosis and ensure appropriate treatment strategies.Radiological imaging plays a key role in distinguishing hydatid cysts from other cystic and neoplastic conditions,while serological tests can aid in confirmation,particularly in endemic regions.A multidisciplinary approach,integrating radiology,clinical evaluation,and surgical expertise,is critical for effective diagnosis and management.This report highlights the need for increased awareness of extrapulmonary and extravisceral hydatid disease,emphasizing its significance in differential diagnosis and clinical practice.展开更多
Protein kinase Cδ(PKCδ)is a member of the PKC family,and its implications have been reported in various biological and cancerous processes,including cell proliferation,cell death,tumor suppression,and tumor progress...Protein kinase Cδ(PKCδ)is a member of the PKC family,and its implications have been reported in various biological and cancerous processes,including cell proliferation,cell death,tumor suppression,and tumor progression.In liver cancer cells,accumulating reports show the bi-functional regulation of PKCδin cell death and survival.PKCδfunction is defined by various factors,such as phosphorylation,catalytic domain cleavage,and subcellular localization.PKCδhas multiple intracellular distribution patterns,ranging from the cytosol to the nucleus.We recently found a unique extracellular localization of PKCδin liver cancer and its growth factor-like function in liver cancer cells.In this review,we first discuss the structural features of PKCδand then focus on the functional diversity of PKCδbased on its subcellular localization,such as the nucleus,cell surface,and extracellular space.These findings improve our knowledge of PKCδinvolvement in the progression of liver cancer.展开更多
All-sky infrared radiance data assimilation has been challenging,due to nonlinear features and complex error statistics.Covariance localization,which is essential for an ensemble Kalman filter applied to high-dimensio...All-sky infrared radiance data assimilation has been challenging,due to nonlinear features and complex error statistics.Covariance localization,which is essential for an ensemble Kalman filter applied to high-dimensional geophysical systems,needs to consider the characteristics of all-sky radiances.To effectively extract information from all-sky radiances that are sensitive to clouds,two adaptive localizations are proposed here.Compared to the previously proposed global group filter(GGF-FS)that adaptively estimates localization lengthscales based on sample correlations,one simultaneously takes the vertical location and localization lengthscales into account(GGF-VS),and the other further considers the impacts of cloud top pressure and brightness temperature on the adaptive localization parameters(GGF-VLS).Both GGF-VS and GGF-VLS have broader vertical localization lengthscales and better capture the TC structure than GGF-FS,and GGF-VLS has larger variations of localization parameters than GGF-VS.Data assimilation experiments for assimilating all-sky infrared radiances confirm that GGF-VS has smaller errors of state variables than GGF-FS,and GGF-VLS further reduces the errors compared to GGF-FS and GGF-VS.Moreover,the more detailed adaptive localization parameters are beneficial for the TC intensity forecast.GGF-VS and GGF-VLS produce smaller errors and ensemble spread for the minimum sea level pressure and maximum wind speed than GGF-FS.GGF-VLS further improves the TC intensity forecast than GGF-VS,and both produce more coherent TC structures that are favored for intensified TC than GGF-FS,including the stronger warm core,more moisture at low levels,and enhanced primary and secondary circulations.展开更多
Let(B,E,s)be an extriangulated category and S be an extension closed subcategory of B.In this article,we prove that the Gabriel-Zisman localization B/S can be realized as an ideal quotient inside B when S satisfies so...Let(B,E,s)be an extriangulated category and S be an extension closed subcategory of B.In this article,we prove that the Gabriel-Zisman localization B/S can be realized as an ideal quotient inside B when S satisfies some mild conditions.The ideal quotient is an extriangulated category.We show that the equivalence between the ideal quotient and the localization preserves the extriangulated category structure.We also discuss the relations of our results with Hovey twin cotorsion pairs and Verdier quotients.展开更多
基于国际比较的地方空间规划的范围和工具研究An International Comparison of the Scope and Instruments of Local Spatial Planning源自:The TownPlanning Review,2024,95(2):197-217作者:MaciejJNowak,StefanieDühr,Sergio Pe&...基于国际比较的地方空间规划的范围和工具研究An International Comparison of the Scope and Instruments of Local Spatial Planning源自:The TownPlanning Review,2024,95(2):197-217作者:MaciejJNowak,StefanieDühr,Sergio Peña,et al.推荐:申明锐,南京大学建筑与城市规划学院。shenmingr@nju.edu.cn.展开更多
Graphene has great potential for enhancing light−matter interactions in a two-dimensional regime due to surface plasmons with low loss and strong light confinement.Further utilization of graphene in nanophotonics reli...Graphene has great potential for enhancing light−matter interactions in a two-dimensional regime due to surface plasmons with low loss and strong light confinement.Further utilization of graphene in nanophotonics relies on the precise control of light localization properties.Here,we demonstrate the tailoring of electromagnetic field localizations in the mid-infrared region by precisely shaping the graphene into nanostructures with different geometries.We generalize the phenomenological cavity model and employ nanoimaging techniques to quantitatively calculate and experimentally visualize the two-dimensional electromagnetic field distributions within the nanostructures,which indicate that the electromagnetic field can be shaped into specific patterns depending on the shapes and sizes of the nanostructures.Furthermore,we show that the light localization performance can be further improved by reducing the sizes of the nanostructures,where a lateral confinement of λ0/180 of the incidence light can be achieved.The electromagnetic field localizations within a nanostructure with a specific geometry can also be modulated by chemical doping.Our strategies can,in principle,be generalized to other two-dimensional materials,therefore providing new degrees of freedom for designing nanophotonic components capable of tailoring two-dimensional light confinement over a broad wavelength range.展开更多
Visible and infrared(RGB-IR)fusion object detection plays an important role in security,disaster relief,etc.In recent years,deep-learning-based RGB-IR fusion detection methods have been developing rapidly,but still st...Visible and infrared(RGB-IR)fusion object detection plays an important role in security,disaster relief,etc.In recent years,deep-learning-based RGB-IR fusion detection methods have been developing rapidly,but still struggle to deal with the complex and changing scenarios captured by drones,mainly due to two reasons:(A)RGB-IR fusion detectors are susceptible to inferior inputs that degrade performance and stability.(B)RGB-IR fusion detectors are susceptible to redundant features that reduce accuracy and efficiency.In this paper,an innovative RGB-IR fusion detection framework based on global-local feature optimization,named GLFDet,is proposed to improve the detection performance and efficiency of drone-captured objects.The key components of GLFDet include a Global Feature Optimization(GFO)module,a Local Feature Optimization(LFO)module and a Channel Separation Fusion(CSF)module.Specifically,GFO calculates the information content of the input image from the frequency domain and optimizes the features holistically.Then,LFO dynamically selects high-value features and filters out low-value features before fusion,which significantly improves the efficiency of fusion.Finally,CSF fuses the RGB and IR features across the corresponding channels,which avoids the rearrangement of the channel relationships and enhances the model stability.Extensive experimental results show that the proposed method achieves the best performance on three popular RGB-IR datasets Drone Vehicle,VEDAI,and LLVIP.In addition,GLFDet is more lightweight than other comparable models,making it more appealing to edge devices such as drones.The code is available at https://github.com/lao chen330/GLFDet.展开更多
High-performance deep-blue emitters that meet the BT.2020 standard proposed by the International Telecommunication Union(ITU)for organic light-emitting diodes(OLEDs)remain highly limited.In this work,four deep-blue em...High-performance deep-blue emitters that meet the BT.2020 standard proposed by the International Telecommunication Union(ITU)for organic light-emitting diodes(OLEDs)remain highly limited.In this work,four deep-blue emitters,PP1M,PP2M,PP3M,and PP4M,are designed and synthesized by connecting methylsubstituted biphenyl groups with classical hot exciton building block of phenanthreneimidazole.The introduction of methyl groups contributes to increase the molecular torsion angle and widen the energy gaps for the four compounds.Through appropriate modulation of substitution site,PP3M achieves the highest photoluminescence quantum yield of 85.3%in neat film.As a result,the PP3M-based device exhibits deep-blue light with external quantum efficiency of 7.2%and suppressed efficiency roll-off.The device also shows a small full width at half maximum of 53 nm and the CIE coordinates locate at(0.16,0.04),meeting well with the BT.2020 standard.The high exciton utilization efficiency is primarily ascribed to the hot exciton pathway.This study provides a reliable insight for the design of efficient deep-blue OLEDs with high color purity.展开更多
The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of ris...The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of risk substances(including local anesthetics,LAs)in cosmetics,which has been successfully applied in the analysis of actual samples.This work aims to develop a more convenient high performance liquid chromatography triple quadrupole mass spectrometry(HPLC-QQQ-MS/MS)method for the quantitative determination of LAs.Samples were ultrasonically extracted with methanol,separated on an Agilent Poroshell 120 EC-C18 column(2.1 mm×100 mm,2.7μm),and eluted with a gradient mobile phase consisting of 0.1%formic acid aqueous solution and methanol.Quantification was performed using the external standard method.The results show that all 23 LAs are effectively separated within 12 minutes,with good linearity in the corresponding concentration ranges and the correlation coefficients all greater than 0.99.The limits of detection(LOD)range from 0.0025 to 0.05μg/g,and the limits of quantification(LOQ)range from 0.01 to 0.1μg/g.The average recoveries of the 23 LAs in 5 blank cosmetic matrices are 80.68%-117.57%,with the relative standard deviations(RSDs)less than 5.98%.This method has good precision and high accuracy,and is suitable for the determination of LAs in 5 cosmetic matrices.展开更多
Background and Objectives:The perception of sound in the vertical plane supports spatial hearing by enabling listeners to detect sources located above and below.Sounds originating from both the front and back elevatio...Background and Objectives:The perception of sound in the vertical plane supports spatial hearing by enabling listeners to detect sources located above and below.Sounds originating from both the front and back elevations along the mid-sagittal plane further contribute to a three-dimensional auditory experience.This study aimed to characterize the variability in vertical sound localization abilities among normal-hearing(NH)individuals using spatialized audio.Materials and Methods:Fifty-one NH participants(aged 18 to 35 years)completed three vertical localization tasks under headphones as part of a single-group,within-subject experimental study.These tasks included two-plane identification:(1)top-down localization,(2)front-back localization,and one discrimination task in the front plane.Hierarchical Cluster Analysis(HCA)was employed to identify distinct patterns in spatial localization profiles specific to the vertical-median plane.Fisher's Discriminant Function Analysis(FDA)was used to validate the accuracy of HCA and estimate classification error.Results:HCA revealed three distinct listener clusters:(1)cluster 1 with good performance across all three tasks,(2)cluster 2 with selective impairment in top-bottom identification,and(3)cluster 3 with selective deficits in front-back identification.FDA validated group membership of the clusters identified by the HCA,with a prediction accuracy of 98%.Conclusions:Individuals with clinically NH exhibited three distinct vertical localization profiles:uniform performers,those impaired in top-bottom identification,and those impaired in front-back identification.These profiles may be linked to the interplay between acoustic and non-acoustic perceptual factors.展开更多
Amylose content(AC)is a key determinant of rice eating and cooking quality(ECQ).Lower AC is generally associated with improved palatability and is therefore a desirable trait in rice breeding;however,effective manipul...Amylose content(AC)is a key determinant of rice eating and cooking quality(ECQ).Lower AC is generally associated with improved palatability and is therefore a desirable trait in rice breeding;however,effective manipulation of AC remains a challenge.In this study,we identified AC6,a novel endosperm-specific early nodulin-like(ENODL)gene,belonging to a 32-member ENODL family.Using CRISPR/Cas9 technology,we generated an ac6 knockout allele,which exhibited a significant decrease in AC and produced improved ECQ without compromising grain appearance or yield.Subcellular localization analysis demonstrated that AC6 is a plastid-localized protein that likely regulates AC by interacting with the Waxy(Wx)protein.Moreover,expression of starch metabolism-related genes was markedly altered in developing ac6 endosperm.Our study highlights AC6 as a novel target gene for engineering rice germplasm with enhanced ECQ.展开更多
Heart disease remains a leading cause of mortality worldwide,emphasizing the urgent need for reliable and interpretable predictive models to support early diagnosis and timely intervention.However,existing Deep Learni...Heart disease remains a leading cause of mortality worldwide,emphasizing the urgent need for reliable and interpretable predictive models to support early diagnosis and timely intervention.However,existing Deep Learning(DL)approaches often face several limitations,including inefficient feature extraction,class imbalance,suboptimal classification performance,and limited interpretability,which collectively hinder their deployment in clinical settings.To address these challenges,we propose a novel DL framework for heart disease prediction that integrates a comprehensive preprocessing pipeline with an advanced classification architecture.The preprocessing stage involves label encoding and feature scaling.To address the issue of class imbalance inherent in the personal key indicators of the heart disease dataset,the localized random affine shadowsampling technique is employed,which enhances minority class representation while minimizing overfitting.At the core of the framework lies the Deep Residual Network(DeepResNet),which employs hierarchical residual transformations to facilitate efficient feature extraction and capture complex,non-linear relationships in the data.Experimental results demonstrate that the proposed model significantly outperforms existing techniques,achieving improvements of 3.26%in accuracy,3.16%in area under the receiver operating characteristics,1.09%in recall,and 1.07%in F1-score.Furthermore,robustness is validated using 10-fold crossvalidation,confirming the model’s generalizability across diverse data distributions.Moreover,model interpretability is ensured through the integration of Shapley additive explanations and local interpretable model-agnostic explanations,offering valuable insights into the contribution of individual features to model predictions.Overall,the proposed DL framework presents a robust,interpretable,and clinically applicable solution for heart disease prediction.展开更多
The application potential of tuning two-dimensional materials(2DMs)characteristics through strain engineering for wearable and flexible devices has been widely recognized.However,the challenges lie in achieving accura...The application potential of tuning two-dimensional materials(2DMs)characteristics through strain engineering for wearable and flexible devices has been widely recognized.However,the challenges lie in achieving accurate deterministic positioning,spatial modulation,controllable magnitude,and permanent nanostrains.Herein,motivated by the skin swelling caused by mosquito bites,a technique utilizing the heated nanotip in atomic force microscopy for thermomechanical nanoindentation is demonstrated.This method enables precise positioning of localized nanostrain and regulation of bandgap in tungsten diselenide(WSe_(2))/molybdenum disulfide(MoS_(2))heterobilayer transferred onto a flexible polymethyl methacrylate film.The magnitude of strain in the WSe_(2)/MoS_(2) heterobilayer can be controlled by adjusting the parameters of nanoindentation,leading to a spatially modulated average strain of up to 2.5%on the ring-shaped expansion structure(RES).The local bandgap of the WSe_(2)/MoS_(2) heterobilayer is spatially regulated through three distinct regions.In particular,the RES exhibits the largest extent of bandgap modulation,accompanied by a significant change of~12 meV.The nanostrain significantly enhances the photoresponse speed of the photodetector device.For instance,under illumination from a 405 nm wavelength-laser,the rise time and fall time are reduced by 75%and 87.52%,respectively,compared to the device without strain.Similarly,under illumination from a 532 nm wavelength-laser,the rise time and fall time are reduced by 66.67%and 80.60%,respectively.These findings demonstrate that the proposed method serves as a versatile way for improving the photoresponse of optoelectronic devices based on 2DMs.展开更多
Local residents,artists,and entrepreneurs who converge on Haikou’s historical Qilou Street are contributing to a new chapter in the story of Hainan’s opening-up.MORE than 100 years ago,the area alongQilou(Sotto Port...Local residents,artists,and entrepreneurs who converge on Haikou’s historical Qilou Street are contributing to a new chapter in the story of Hainan’s opening-up.MORE than 100 years ago,the area alongQilou(Sotto Portico)Street in Haikou,capital of Hainan Province,served asthe embarkation point for Hainanesesetting out on their maritime voyages to seek greener pastures.展开更多
BACKGROUND Data comparing the outcomes of hepatocellular carcinoma(HCC)ablation by multibipolar radiofrequency ablation(mbp-RFA)and microwave ablation(MWA)are lacking.This study compares safety and efficacy of the two...BACKGROUND Data comparing the outcomes of hepatocellular carcinoma(HCC)ablation by multibipolar radiofrequency ablation(mbp-RFA)and microwave ablation(MWA)are lacking.This study compares safety and efficacy of the two techniques in treatment-naive HCC.AIM To compare the risk of local tumor progression(LTP)according to the technique;secondary endpoints included technique efficacy rate at one-month,overall survival and major complication rate.METHODS A bi-institutional retrospective analysis of patients undergoing treatment-naive HCC ablation by either technique was performed.Inverse probability of treatment weighting was used to compare the two groups.Mixed effects multivariate Cox regression was applied to identify risk factors for LTP.RESULTS A total of 362 patients(mean age,66.1±6.2 years,308 men)were included,of which 242(323 tumors)treated by mbp-RFA and 120(168 tumors)by MWA.After a median follow-up of 27 months,cumulative LTP was 11.4%after mbp-RFA and 25.2%after MWA.Independent risk factors for LTP at multivariate analysis were MWA(hazard ratio=2.85,P<0.001)and tumor size(hazard ratio=1.08,P<0.001).Two-year LTP-free survival was higher after mbp-RFA than MWA regardless of size(<3 cm:96%vs 87.1%,P<0.01;≥3 cm:87.5%vs 74%,P=0.04).Technique efficacy rate was higher after mbp-RFA(94.1%vs 87.5%,P=0.01).No difference was observed in major complication rate(9.5%vs 7.5%,P=0.59),nor 5-year overall survival(63.6%vs 58.3%,P=0.33).CONCLUSION Mbp-RFA leads to better local tumor control of treatment-naïve HCC than MWA regardless of tumor size and has better primary efficacy,while maintaining a comparable safety profile.展开更多
This paper proposes a tamper detection technique for semi-fragile watermarking using Quantizationbased Discrete Cosine Transform(DCT)for tamper localization.In this study,the proposed embedding strategy is investigate...This paper proposes a tamper detection technique for semi-fragile watermarking using Quantizationbased Discrete Cosine Transform(DCT)for tamper localization.In this study,the proposed embedding strategy is investigated by experimental tests over the diagonal order of the DCT coefficients.The cover image is divided into non-overlapping blocks of size 8×8 pixels.The DCT is applied to each block,and the coefficients are arranged using a zig-zag pattern within the block.In this study,the low-frequency coefficients are selected to examine the impact of the imperceptibility score and tamper detection accuracy.High accuracy of tamper detection can be achieved by checking the surrounding blocks to determine whether the corresponding block has been tampered with.The proposed tamper detection is tested under various malicious,incidental,and hybrid attacks(both incidental and malicious attacks).The experimental results demonstrate that the proposed technique achieves a Peak-Signal-to-Noise Ratio(PSNR)value of 41.2318 dB,an average Structural Similarity Index Measure(SSIM)value of 0.9768.The proposed scheme is also evaluated against malicious attacks such as copy-move,object deletion,object manipulation,and collage attacks.The proposed scheme can detect the malicious attack localization under various tampering rates.In addition,the proposed scheme can still detect tampered pixels under a hybrid attack,such as a combination ofmalicious and incidental attacks,with an average accuracy of 96.44%.展开更多
Despite remarkable advances in nanomedicine,localized delivery of advanced cancer therapeutics remains underexploited.Advanced therapies based on biopharmaceuticals,immunotherapy,or gene therapy have revolutionized on...Despite remarkable advances in nanomedicine,localized delivery of advanced cancer therapeutics remains underexploited.Advanced therapies based on biopharmaceuticals,immunotherapy,or gene therapy have revolutionized oncology.Yet,their systemic administration is often associated with limitations such as poor sitespecific accumulation,instability,and systemic toxicity.Hydrogels/macrogels offer the ability to encapsulate,protect,and release biomolecules in situ with sustained and stimulus-responsive profiles,addressing key translational gaps.This review provides a focused synthesis of the last five years of hydrogel-based research for cancer therapy,with emphasis on peptides,antibodies,immunotherapeutic agents,and gene delivery systems.We discuss design principles,release mechanisms,and clinical translation challenges,highlighting structure-function relationships and comparative performance across therapeutic classes.By integrating mechanistic insights with recent breakthroughs,we outline how next-generation hydrogels can synergize with personalized medicine and combination therapies to redefine localized cancer treatment.This work explores the fundamental aspects and provides examples of hydrogel-based delivery for the advanced treatment of cancer.The review summarizes the dynamic landscape of hydrogel research of the last 5 years,showcasing their potential systems for the precise delivery of biomolecules.Specifically,we explore the multidimensional role of hydrogels in the sustained and localized release of antibodies,immunotherapeutic agents,and genes as next-generation platforms for localized cancer treatment.This review aims to critically evaluate the mechanisms and applications of these systems in order to assess their potential to transform medical interventions and advance patient care.展开更多
Localized high-concentration electrolytes(LHCEs)are considered as promising electrolyte candidates to resolve technical issues of metal batteries owing to their unique interfacial properties and solvation structures.H...Localized high-concentration electrolytes(LHCEs)are considered as promising electrolyte candidates to resolve technical issues of metal batteries owing to their unique interfacial properties and solvation structures.Herein,we propose a self-assembly chemical strategy into the LCHEs induced by ordered nanostructure of zwitterionic co-solutes for highly efficient and ultrastable zinc(Zn)metal batteries.Through the systematic screening of six zwitterionic compounds,3-(decyldimethylammonio)propanesulfonate salt(C_(10))with the decyl chain and zwitterions was determined as an optimum to construct quasi-spherical aggregates with a periodic length of 3.77 nm,as confirmed by comprehensive synchronous small-angle X-ray scattering,Guinier,pair distance distribution function,Porod,and other spectroscopic characterizations and molecular dynamic simulation.In particularly,this self-assembled structure in electrolyte environments was attributed to increasing the proportion of both contact and aggregated ion pairs for the formation of LHCEs as well as to providing fast and selective Zn^(2+)conducting channels and uniform solid electrolyte interfaces for facilitated charge transfer kinetics.Moreover,the preferential adsorption of the self-assembled C_(10)on the Zn(002)surface modulated the electrical double layer to suppress hydrogen evolution and corrosion reactions.Consequently,the Zn‖Zn symmetric cells in Zn(OTf)_(2)/C_(10)electrolytes showed long-term plating/stripping behaviors over 2800 h at 1 mA cm^(-2)and 1 mAh cm^(-2)as well as over 1200 h even at 5 mA cm^(-2)and 5 mAh cm^(-2)with a very high depth of discharge of 42.7%.Furthermore,the ZnllVO_(2)/CNT full cells in Zn(OTf)_(2)/C_(10)electrolytes delivered a record-high capacity of 8.10 mAh cm^(-2)at an ultrahigh cathode mass loading of 50 mg cm^(-2)after 150 cycles.展开更多
文摘Hydatid disease,caused by the Echinococcus granulosus parasite,is traditionally associated with liver and lung involvement.However,recent years have seen an increase in cases with atypical localizations,such as the kidneys,thyroid,soft tissues,and bones.The study by Celik et al presents a series of five clinical cases where hydatid cysts were found in these rare anatomical regions,challenging conventional diagnostic and therapeutic approaches.The paper emphasizes the importance of differential diagnosis,as these cases can mimic other conditions,such as cancer,abscesses,or cysts.Advanced imaging techniques,such as com-puted tomography,magnetic resonance imaging,and ultrasound,play a crucial role in accurate diagnosis and help avoid misdiagnosis.The study demonstrates that early diagnosis and appropriate treatment of echinococosis in atypical localiz-ations are critical for preventing complications like cyst rupture and secondary infections.The use of albendazole and surgical intervention,especially in combi-nation with modern imaging techniques,yields good outcomes in these patients.However,several unanswered questions remain:What are the precise criteria for selecting the optimal treatment method in each case?What is the long-term effect-iveness of different approaches?Do patients with hydatid cysts in atypical lo-cations require additional monitoring and preventive treatment to avoid recu-rrence?Addressing these questions requires further research,and a multidisci-plinary approach involving radiologists,surgeons,and infectious disease spe-cialists is essential to optimize diagnosis and treatment.Early and accurate diagnostic methods based on differential diagnosis play a key role in improving treatment outcomes and reducing morbidity.
文摘BACKGROUND Hydatid cyst disease,caused by Echinococcus granulosus,primarily affects the liver and lungs,but it can also develop in rare locations such as the kidneys,thyroid,subcutaneous tissues,bones,and the mediastinum.These atypical presentations often pose diagnostic challenges,as they can mimic benign and malignant pathologies,leading to potential misdiagnoses and inappropriate treatments.Early and accurate detection of hydatid cysts in uncommon sites is crucial for optimal patient management.CASE SUMMARY This case report series presents five patients with hydatid cysts located in atypical anatomical regions:The kidney,lumbar subcutaneous tissue,gluteal soft tissue,posterior mediastinum,and thyroid gland.The patients exhibited diverse clinical symptoms,including hematuria,palpable masses,localized pain,and chronic cough.Diagnosis was confirmed through a combination of imaging techniquesultrasound,computed tomography,and magnetic resonance imaging-along with serological testing.All cases were managed with antiparasitic therapy(albendazole),and in selected cases,surgical excision was performed to prevent complications such as cyst rupture or secondary infections.Post-treatment follow-up demonstrated complete resolution or stable cystic lesions,with no signs of recurrence.CONCLUSION Recognizing hydatid cysts in atypical locations is essential to avoid misdiagnosis and ensure appropriate treatment strategies.Radiological imaging plays a key role in distinguishing hydatid cysts from other cystic and neoplastic conditions,while serological tests can aid in confirmation,particularly in endemic regions.A multidisciplinary approach,integrating radiology,clinical evaluation,and surgical expertise,is critical for effective diagnosis and management.This report highlights the need for increased awareness of extrapulmonary and extravisceral hydatid disease,emphasizing its significance in differential diagnosis and clinical practice.
基金Supported by the Japan Society for the Promotion of Science,KAKENHI Grant,No.19H03519,16K18434,and 18K15253 to Yamada K,No.17H03584,18K19484,and 20H03519 to Yoshida KAMED under Grant No.A326TS to Yamada K+1 种基金The Jikei University Graduate Research Fund to Yamada Kand the Science Research Promotion Fund to Yoshida K.
文摘Protein kinase Cδ(PKCδ)is a member of the PKC family,and its implications have been reported in various biological and cancerous processes,including cell proliferation,cell death,tumor suppression,and tumor progression.In liver cancer cells,accumulating reports show the bi-functional regulation of PKCδin cell death and survival.PKCδfunction is defined by various factors,such as phosphorylation,catalytic domain cleavage,and subcellular localization.PKCδhas multiple intracellular distribution patterns,ranging from the cytosol to the nucleus.We recently found a unique extracellular localization of PKCδin liver cancer and its growth factor-like function in liver cancer cells.In this review,we first discuss the structural features of PKCδand then focus on the functional diversity of PKCδbased on its subcellular localization,such as the nucleus,cell surface,and extracellular space.These findings improve our knowledge of PKCδinvolvement in the progression of liver cancer.
基金supported by the National Natural Science Foundation of China(Grant No.42450168)the Science and Technology Innovation Project of Laoshan Laboratory(Grant No.LSKJ202203303)+2 种基金the Science and Technology Project of State Grid Zhejiang Electric Power Engineering Research Institute(Grant No.5211DS25000L)the Fundamental Research Funds for the Central Universities-Cemac“Geo X”Interdisciplinary Program(Grant No.020714380207)the Fund for Postgraduate Research and Practice Innovation Program of Jiangsu Province(Grant No.KYCX22_0114)。
文摘All-sky infrared radiance data assimilation has been challenging,due to nonlinear features and complex error statistics.Covariance localization,which is essential for an ensemble Kalman filter applied to high-dimensional geophysical systems,needs to consider the characteristics of all-sky radiances.To effectively extract information from all-sky radiances that are sensitive to clouds,two adaptive localizations are proposed here.Compared to the previously proposed global group filter(GGF-FS)that adaptively estimates localization lengthscales based on sample correlations,one simultaneously takes the vertical location and localization lengthscales into account(GGF-VS),and the other further considers the impacts of cloud top pressure and brightness temperature on the adaptive localization parameters(GGF-VLS).Both GGF-VS and GGF-VLS have broader vertical localization lengthscales and better capture the TC structure than GGF-FS,and GGF-VLS has larger variations of localization parameters than GGF-VS.Data assimilation experiments for assimilating all-sky infrared radiances confirm that GGF-VS has smaller errors of state variables than GGF-FS,and GGF-VLS further reduces the errors compared to GGF-FS and GGF-VS.Moreover,the more detailed adaptive localization parameters are beneficial for the TC intensity forecast.GGF-VS and GGF-VLS produce smaller errors and ensemble spread for the minimum sea level pressure and maximum wind speed than GGF-FS.GGF-VLS further improves the TC intensity forecast than GGF-VS,and both produce more coherent TC structures that are favored for intensified TC than GGF-FS,including the stronger warm core,more moisture at low levels,and enhanced primary and secondary circulations.
基金supported by National Natural Science Foundation of China(Grant No.12171397)Panyue Zhou was supported by National Natural Science Foundation of China(Grant No.12371034)the Hunan Provincial Natural Science Foundation of China(Grant No.2023JJ30008)。
文摘Let(B,E,s)be an extriangulated category and S be an extension closed subcategory of B.In this article,we prove that the Gabriel-Zisman localization B/S can be realized as an ideal quotient inside B when S satisfies some mild conditions.The ideal quotient is an extriangulated category.We show that the equivalence between the ideal quotient and the localization preserves the extriangulated category structure.We also discuss the relations of our results with Hovey twin cotorsion pairs and Verdier quotients.
文摘基于国际比较的地方空间规划的范围和工具研究An International Comparison of the Scope and Instruments of Local Spatial Planning源自:The TownPlanning Review,2024,95(2):197-217作者:MaciejJNowak,StefanieDühr,Sergio Peña,et al.推荐:申明锐,南京大学建筑与城市规划学院。shenmingr@nju.edu.cn.
基金supported by the National Natural Science Foundation of China(Grant Nos.51290271,11474364 and 51290273)the National Key Basic Research Program of China(Grant Nos.2013CB933601 and 2013YQ12034506)the Guangdong Natural Science Funds for Distinguished Young Scholars(Grant No.2014A030306017)。
文摘Graphene has great potential for enhancing light−matter interactions in a two-dimensional regime due to surface plasmons with low loss and strong light confinement.Further utilization of graphene in nanophotonics relies on the precise control of light localization properties.Here,we demonstrate the tailoring of electromagnetic field localizations in the mid-infrared region by precisely shaping the graphene into nanostructures with different geometries.We generalize the phenomenological cavity model and employ nanoimaging techniques to quantitatively calculate and experimentally visualize the two-dimensional electromagnetic field distributions within the nanostructures,which indicate that the electromagnetic field can be shaped into specific patterns depending on the shapes and sizes of the nanostructures.Furthermore,we show that the light localization performance can be further improved by reducing the sizes of the nanostructures,where a lateral confinement of λ0/180 of the incidence light can be achieved.The electromagnetic field localizations within a nanostructure with a specific geometry can also be modulated by chemical doping.Our strategies can,in principle,be generalized to other two-dimensional materials,therefore providing new degrees of freedom for designing nanophotonic components capable of tailoring two-dimensional light confinement over a broad wavelength range.
基金supported by the National Natural Science Foundation of China(No.62276204)the Fundamental Research Funds for the Central Universities,China(No.YJSJ24011)+1 种基金the Natural Science Basic Research Program of Shaanxi,China(Nos.2022JM-340 and 2023-JC-QN-0710)the China Postdoctoral Science Foundation(Nos.2020T130494 and 2018M633470)。
文摘Visible and infrared(RGB-IR)fusion object detection plays an important role in security,disaster relief,etc.In recent years,deep-learning-based RGB-IR fusion detection methods have been developing rapidly,but still struggle to deal with the complex and changing scenarios captured by drones,mainly due to two reasons:(A)RGB-IR fusion detectors are susceptible to inferior inputs that degrade performance and stability.(B)RGB-IR fusion detectors are susceptible to redundant features that reduce accuracy and efficiency.In this paper,an innovative RGB-IR fusion detection framework based on global-local feature optimization,named GLFDet,is proposed to improve the detection performance and efficiency of drone-captured objects.The key components of GLFDet include a Global Feature Optimization(GFO)module,a Local Feature Optimization(LFO)module and a Channel Separation Fusion(CSF)module.Specifically,GFO calculates the information content of the input image from the frequency domain and optimizes the features holistically.Then,LFO dynamically selects high-value features and filters out low-value features before fusion,which significantly improves the efficiency of fusion.Finally,CSF fuses the RGB and IR features across the corresponding channels,which avoids the rearrangement of the channel relationships and enhances the model stability.Extensive experimental results show that the proposed method achieves the best performance on three popular RGB-IR datasets Drone Vehicle,VEDAI,and LLVIP.In addition,GLFDet is more lightweight than other comparable models,making it more appealing to edge devices such as drones.The code is available at https://github.com/lao chen330/GLFDet.
文摘High-performance deep-blue emitters that meet the BT.2020 standard proposed by the International Telecommunication Union(ITU)for organic light-emitting diodes(OLEDs)remain highly limited.In this work,four deep-blue emitters,PP1M,PP2M,PP3M,and PP4M,are designed and synthesized by connecting methylsubstituted biphenyl groups with classical hot exciton building block of phenanthreneimidazole.The introduction of methyl groups contributes to increase the molecular torsion angle and widen the energy gaps for the four compounds.Through appropriate modulation of substitution site,PP3M achieves the highest photoluminescence quantum yield of 85.3%in neat film.As a result,the PP3M-based device exhibits deep-blue light with external quantum efficiency of 7.2%and suppressed efficiency roll-off.The device also shows a small full width at half maximum of 53 nm and the CIE coordinates locate at(0.16,0.04),meeting well with the BT.2020 standard.The high exciton utilization efficiency is primarily ascribed to the hot exciton pathway.This study provides a reliable insight for the design of efficient deep-blue OLEDs with high color purity.
文摘The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of risk substances(including local anesthetics,LAs)in cosmetics,which has been successfully applied in the analysis of actual samples.This work aims to develop a more convenient high performance liquid chromatography triple quadrupole mass spectrometry(HPLC-QQQ-MS/MS)method for the quantitative determination of LAs.Samples were ultrasonically extracted with methanol,separated on an Agilent Poroshell 120 EC-C18 column(2.1 mm×100 mm,2.7μm),and eluted with a gradient mobile phase consisting of 0.1%formic acid aqueous solution and methanol.Quantification was performed using the external standard method.The results show that all 23 LAs are effectively separated within 12 minutes,with good linearity in the corresponding concentration ranges and the correlation coefficients all greater than 0.99.The limits of detection(LOD)range from 0.0025 to 0.05μg/g,and the limits of quantification(LOQ)range from 0.01 to 0.1μg/g.The average recoveries of the 23 LAs in 5 blank cosmetic matrices are 80.68%-117.57%,with the relative standard deviations(RSDs)less than 5.98%.This method has good precision and high accuracy,and is suitable for the determination of LAs in 5 cosmetic matrices.
文摘Background and Objectives:The perception of sound in the vertical plane supports spatial hearing by enabling listeners to detect sources located above and below.Sounds originating from both the front and back elevations along the mid-sagittal plane further contribute to a three-dimensional auditory experience.This study aimed to characterize the variability in vertical sound localization abilities among normal-hearing(NH)individuals using spatialized audio.Materials and Methods:Fifty-one NH participants(aged 18 to 35 years)completed three vertical localization tasks under headphones as part of a single-group,within-subject experimental study.These tasks included two-plane identification:(1)top-down localization,(2)front-back localization,and one discrimination task in the front plane.Hierarchical Cluster Analysis(HCA)was employed to identify distinct patterns in spatial localization profiles specific to the vertical-median plane.Fisher's Discriminant Function Analysis(FDA)was used to validate the accuracy of HCA and estimate classification error.Results:HCA revealed three distinct listener clusters:(1)cluster 1 with good performance across all three tasks,(2)cluster 2 with selective impairment in top-bottom identification,and(3)cluster 3 with selective deficits in front-back identification.FDA validated group membership of the clusters identified by the HCA,with a prediction accuracy of 98%.Conclusions:Individuals with clinically NH exhibited three distinct vertical localization profiles:uniform performers,those impaired in top-bottom identification,and those impaired in front-back identification.These profiles may be linked to the interplay between acoustic and non-acoustic perceptual factors.
基金supported by the Government of Jiangsu Province,China(Grant Nos.23KJA210001,BE2023331,KYCX21_3247,and BE2021334)the National Natural Science Foundation of China(Grant Nos.31971914 and 32472072).
文摘Amylose content(AC)is a key determinant of rice eating and cooking quality(ECQ).Lower AC is generally associated with improved palatability and is therefore a desirable trait in rice breeding;however,effective manipulation of AC remains a challenge.In this study,we identified AC6,a novel endosperm-specific early nodulin-like(ENODL)gene,belonging to a 32-member ENODL family.Using CRISPR/Cas9 technology,we generated an ac6 knockout allele,which exhibited a significant decrease in AC and produced improved ECQ without compromising grain appearance or yield.Subcellular localization analysis demonstrated that AC6 is a plastid-localized protein that likely regulates AC by interacting with the Waxy(Wx)protein.Moreover,expression of starch metabolism-related genes was markedly altered in developing ac6 endosperm.Our study highlights AC6 as a novel target gene for engineering rice germplasm with enhanced ECQ.
基金funded by Ongoing Research Funding Program for Project number(ORF-2025-648),King Saud University,Riyadh,Saudi Arabia.
文摘Heart disease remains a leading cause of mortality worldwide,emphasizing the urgent need for reliable and interpretable predictive models to support early diagnosis and timely intervention.However,existing Deep Learning(DL)approaches often face several limitations,including inefficient feature extraction,class imbalance,suboptimal classification performance,and limited interpretability,which collectively hinder their deployment in clinical settings.To address these challenges,we propose a novel DL framework for heart disease prediction that integrates a comprehensive preprocessing pipeline with an advanced classification architecture.The preprocessing stage involves label encoding and feature scaling.To address the issue of class imbalance inherent in the personal key indicators of the heart disease dataset,the localized random affine shadowsampling technique is employed,which enhances minority class representation while minimizing overfitting.At the core of the framework lies the Deep Residual Network(DeepResNet),which employs hierarchical residual transformations to facilitate efficient feature extraction and capture complex,non-linear relationships in the data.Experimental results demonstrate that the proposed model significantly outperforms existing techniques,achieving improvements of 3.26%in accuracy,3.16%in area under the receiver operating characteristics,1.09%in recall,and 1.07%in F1-score.Furthermore,robustness is validated using 10-fold crossvalidation,confirming the model’s generalizability across diverse data distributions.Moreover,model interpretability is ensured through the integration of Shapley additive explanations and local interpretable model-agnostic explanations,offering valuable insights into the contribution of individual features to model predictions.Overall,the proposed DL framework presents a robust,interpretable,and clinically applicable solution for heart disease prediction.
基金financial supports of the National Natural Science Foundation of China(52222512)。
文摘The application potential of tuning two-dimensional materials(2DMs)characteristics through strain engineering for wearable and flexible devices has been widely recognized.However,the challenges lie in achieving accurate deterministic positioning,spatial modulation,controllable magnitude,and permanent nanostrains.Herein,motivated by the skin swelling caused by mosquito bites,a technique utilizing the heated nanotip in atomic force microscopy for thermomechanical nanoindentation is demonstrated.This method enables precise positioning of localized nanostrain and regulation of bandgap in tungsten diselenide(WSe_(2))/molybdenum disulfide(MoS_(2))heterobilayer transferred onto a flexible polymethyl methacrylate film.The magnitude of strain in the WSe_(2)/MoS_(2) heterobilayer can be controlled by adjusting the parameters of nanoindentation,leading to a spatially modulated average strain of up to 2.5%on the ring-shaped expansion structure(RES).The local bandgap of the WSe_(2)/MoS_(2) heterobilayer is spatially regulated through three distinct regions.In particular,the RES exhibits the largest extent of bandgap modulation,accompanied by a significant change of~12 meV.The nanostrain significantly enhances the photoresponse speed of the photodetector device.For instance,under illumination from a 405 nm wavelength-laser,the rise time and fall time are reduced by 75%and 87.52%,respectively,compared to the device without strain.Similarly,under illumination from a 532 nm wavelength-laser,the rise time and fall time are reduced by 66.67%and 80.60%,respectively.These findings demonstrate that the proposed method serves as a versatile way for improving the photoresponse of optoelectronic devices based on 2DMs.
文摘Local residents,artists,and entrepreneurs who converge on Haikou’s historical Qilou Street are contributing to a new chapter in the story of Hainan’s opening-up.MORE than 100 years ago,the area alongQilou(Sotto Portico)Street in Haikou,capital of Hainan Province,served asthe embarkation point for Hainanesesetting out on their maritime voyages to seek greener pastures.
文摘BACKGROUND Data comparing the outcomes of hepatocellular carcinoma(HCC)ablation by multibipolar radiofrequency ablation(mbp-RFA)and microwave ablation(MWA)are lacking.This study compares safety and efficacy of the two techniques in treatment-naive HCC.AIM To compare the risk of local tumor progression(LTP)according to the technique;secondary endpoints included technique efficacy rate at one-month,overall survival and major complication rate.METHODS A bi-institutional retrospective analysis of patients undergoing treatment-naive HCC ablation by either technique was performed.Inverse probability of treatment weighting was used to compare the two groups.Mixed effects multivariate Cox regression was applied to identify risk factors for LTP.RESULTS A total of 362 patients(mean age,66.1±6.2 years,308 men)were included,of which 242(323 tumors)treated by mbp-RFA and 120(168 tumors)by MWA.After a median follow-up of 27 months,cumulative LTP was 11.4%after mbp-RFA and 25.2%after MWA.Independent risk factors for LTP at multivariate analysis were MWA(hazard ratio=2.85,P<0.001)and tumor size(hazard ratio=1.08,P<0.001).Two-year LTP-free survival was higher after mbp-RFA than MWA regardless of size(<3 cm:96%vs 87.1%,P<0.01;≥3 cm:87.5%vs 74%,P=0.04).Technique efficacy rate was higher after mbp-RFA(94.1%vs 87.5%,P=0.01).No difference was observed in major complication rate(9.5%vs 7.5%,P=0.59),nor 5-year overall survival(63.6%vs 58.3%,P=0.33).CONCLUSION Mbp-RFA leads to better local tumor control of treatment-naïve HCC than MWA regardless of tumor size and has better primary efficacy,while maintaining a comparable safety profile.
基金funded by Ministry of Higher Education Malaysia through Universiti Malaysia Pahang Al-Sultan Abdullah under Internal Research Grant(RDU233003).
文摘This paper proposes a tamper detection technique for semi-fragile watermarking using Quantizationbased Discrete Cosine Transform(DCT)for tamper localization.In this study,the proposed embedding strategy is investigated by experimental tests over the diagonal order of the DCT coefficients.The cover image is divided into non-overlapping blocks of size 8×8 pixels.The DCT is applied to each block,and the coefficients are arranged using a zig-zag pattern within the block.In this study,the low-frequency coefficients are selected to examine the impact of the imperceptibility score and tamper detection accuracy.High accuracy of tamper detection can be achieved by checking the surrounding blocks to determine whether the corresponding block has been tampered with.The proposed tamper detection is tested under various malicious,incidental,and hybrid attacks(both incidental and malicious attacks).The experimental results demonstrate that the proposed technique achieves a Peak-Signal-to-Noise Ratio(PSNR)value of 41.2318 dB,an average Structural Similarity Index Measure(SSIM)value of 0.9768.The proposed scheme is also evaluated against malicious attacks such as copy-move,object deletion,object manipulation,and collage attacks.The proposed scheme can detect the malicious attack localization under various tampering rates.In addition,the proposed scheme can still detect tampered pixels under a hybrid attack,such as a combination ofmalicious and incidental attacks,with an average accuracy of 96.44%.
基金supported by the Vall d’Hebron Research Institute(PI23/01345)the Networking Research Centre on Bioengineering,Biomaterials,and Nanomedicine(CIBER-BBN),which is financed by the Instituto de Salud Carlos III(ISCIII)with assistance from the European Regional Development Fund(ERDF)+4 种基金supported by ANID FONDECYT REGULAR(Chile)through project No.1250634,and FOVI230019 granted to Esteban Duran-LaraDiana Rafael was supported by Marie Skłodowska-Curie Actions(MSCA-PF ID 101107735),“La Caixa Foundation”(LCF/BQ/PR24/12050008),and ISCIII(PI24/00745)Fernanda Andrade was granted by the Fundación Científica de la Asociación Española Contra el Cáncer(FCAECC Refs.INVES211530DASI and SNRGS247164DASI)“La Caixa Foundation”(HR24-00927).Júlia German-Cortés was granted by the 791 FAECC(PRDBA258393GERM)The authors also thank the denomination of Consolidated group from Generalitat de Catalunya(2021 SGR 01173)granted to the CB-DDT group。
文摘Despite remarkable advances in nanomedicine,localized delivery of advanced cancer therapeutics remains underexploited.Advanced therapies based on biopharmaceuticals,immunotherapy,or gene therapy have revolutionized oncology.Yet,their systemic administration is often associated with limitations such as poor sitespecific accumulation,instability,and systemic toxicity.Hydrogels/macrogels offer the ability to encapsulate,protect,and release biomolecules in situ with sustained and stimulus-responsive profiles,addressing key translational gaps.This review provides a focused synthesis of the last five years of hydrogel-based research for cancer therapy,with emphasis on peptides,antibodies,immunotherapeutic agents,and gene delivery systems.We discuss design principles,release mechanisms,and clinical translation challenges,highlighting structure-function relationships and comparative performance across therapeutic classes.By integrating mechanistic insights with recent breakthroughs,we outline how next-generation hydrogels can synergize with personalized medicine and combination therapies to redefine localized cancer treatment.This work explores the fundamental aspects and provides examples of hydrogel-based delivery for the advanced treatment of cancer.The review summarizes the dynamic landscape of hydrogel research of the last 5 years,showcasing their potential systems for the precise delivery of biomolecules.Specifically,we explore the multidimensional role of hydrogels in the sustained and localized release of antibodies,immunotherapeutic agents,and genes as next-generation platforms for localized cancer treatment.This review aims to critically evaluate the mechanisms and applications of these systems in order to assess their potential to transform medical interventions and advance patient care.
基金financially supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(No.NRF-2020R1A3B2079803 and No.RS-2024-00453815),Republic of Korea。
文摘Localized high-concentration electrolytes(LHCEs)are considered as promising electrolyte candidates to resolve technical issues of metal batteries owing to their unique interfacial properties and solvation structures.Herein,we propose a self-assembly chemical strategy into the LCHEs induced by ordered nanostructure of zwitterionic co-solutes for highly efficient and ultrastable zinc(Zn)metal batteries.Through the systematic screening of six zwitterionic compounds,3-(decyldimethylammonio)propanesulfonate salt(C_(10))with the decyl chain and zwitterions was determined as an optimum to construct quasi-spherical aggregates with a periodic length of 3.77 nm,as confirmed by comprehensive synchronous small-angle X-ray scattering,Guinier,pair distance distribution function,Porod,and other spectroscopic characterizations and molecular dynamic simulation.In particularly,this self-assembled structure in electrolyte environments was attributed to increasing the proportion of both contact and aggregated ion pairs for the formation of LHCEs as well as to providing fast and selective Zn^(2+)conducting channels and uniform solid electrolyte interfaces for facilitated charge transfer kinetics.Moreover,the preferential adsorption of the self-assembled C_(10)on the Zn(002)surface modulated the electrical double layer to suppress hydrogen evolution and corrosion reactions.Consequently,the Zn‖Zn symmetric cells in Zn(OTf)_(2)/C_(10)electrolytes showed long-term plating/stripping behaviors over 2800 h at 1 mA cm^(-2)and 1 mAh cm^(-2)as well as over 1200 h even at 5 mA cm^(-2)and 5 mAh cm^(-2)with a very high depth of discharge of 42.7%.Furthermore,the ZnllVO_(2)/CNT full cells in Zn(OTf)_(2)/C_(10)electrolytes delivered a record-high capacity of 8.10 mAh cm^(-2)at an ultrahigh cathode mass loading of 50 mg cm^(-2)after 150 cycles.
