GLOBAL RE-EMERGENCE OF CHIKUNGUNYA VIRUS AND ESCALATING RISKS FOR CHILDREN According to a World Health Organization briefing in July 2025,chikungunya has been reported in 119 countries,placing an estimated 5.5 million...GLOBAL RE-EMERGENCE OF CHIKUNGUNYA VIRUS AND ESCALATING RISKS FOR CHILDREN According to a World Health Organization briefing in July 2025,chikungunya has been reported in 119 countries,placing an estimated 5.5 million people at risk of infection.1 Recent outbreaks have rapidly expanded across Southeast Asia,the Indian Ocean islands,East Africa,South Asia,and southern China,with locally acquired cases even reported in parts of southern Europe.As vectors such as Aedes albopictus continue to spread globally,the geographic reach of the chikungunya virus(CHIKV)is expected to further expand.In July 2025,a chikungunya outbreak was reported in Foshan,Guangdong Province,China,2 with a rapid spread that echoed patterns previously seen in the Indian Ocean islands and parts of sub-Saharan Africa.While CHIKV infections in children were first described in India and South Asia as early as the 1960s,3 the true impact of the virus on pediatric health has been underestimated.展开更多
Introduction:In late August 2025,a locally transmitted CHIKF outbreak was detected in Licheng District,Quanzhou City,Fujian Province.On September 3,2025,two locally acquired cases without travel history to Licheng Dis...Introduction:In late August 2025,a locally transmitted CHIKF outbreak was detected in Licheng District,Quanzhou City,Fujian Province.On September 3,2025,two locally acquired cases without travel history to Licheng District were reported in the adjacent Nan’an City,Quanzhou City.This study aimed to identify the infection source of the local chikungunya cases in Nan’an City.Methods:Field epidemiological investigations were conducted to collect case-related information and trace the infection source.Aedes mosquito density was monitored in the core epidemic area.Whole-genome amplification and sequencing were performed on chikungunya virus(CHIKV)in the serum samples of the cases.The obtained sequences were aligned with those from GenBank,and a phylogenetic tree was constructed for viral genotypic analysis.Results:Nine days before the onset of the two local cases,an imported chikungunya case from Licheng District had received treatment at Clinic E near their residential area.Whole-genome sequencing revealed complete identity among the CHIKV strains from the two local cases and the one imported case,all belonging to the ECSA genotype.Conclusion:Epidemiological link between the locally acquired CHIKF cases in Nan’an City,Quanzhou and the imported case from Licheng District,Quanzhou.In a previously CHIKV-free nonendemic area with Aedes mosquitoes,secondary local cases may emerge approximately 9 days after the introduction of imported viremic cases.展开更多
基金supported by the National Natural Science Foundation of China(Grant/Award Number:82002130)Beijing Natural Science Foundation(Grant/Award Number:7222059)CAMS Innovation Fund for Medical Sciences(Grant/Award Number:2019-I2M-5-026).
文摘GLOBAL RE-EMERGENCE OF CHIKUNGUNYA VIRUS AND ESCALATING RISKS FOR CHILDREN According to a World Health Organization briefing in July 2025,chikungunya has been reported in 119 countries,placing an estimated 5.5 million people at risk of infection.1 Recent outbreaks have rapidly expanded across Southeast Asia,the Indian Ocean islands,East Africa,South Asia,and southern China,with locally acquired cases even reported in parts of southern Europe.As vectors such as Aedes albopictus continue to spread globally,the geographic reach of the chikungunya virus(CHIKV)is expected to further expand.In July 2025,a chikungunya outbreak was reported in Foshan,Guangdong Province,China,2 with a rapid spread that echoed patterns previously seen in the Indian Ocean islands and parts of sub-Saharan Africa.While CHIKV infections in children were first described in India and South Asia as early as the 1960s,3 the true impact of the virus on pediatric health has been underestimated.
基金Supported by the Fujian Research and Training Grants for Young and Middle-aged Leaders in Healthcare(No.[2023]2839)the Technology Major Project for the Prevention and Control of Emerging,Sudden,and Major Infectious Diseases(2026ZD01908800).
文摘Introduction:In late August 2025,a locally transmitted CHIKF outbreak was detected in Licheng District,Quanzhou City,Fujian Province.On September 3,2025,two locally acquired cases without travel history to Licheng District were reported in the adjacent Nan’an City,Quanzhou City.This study aimed to identify the infection source of the local chikungunya cases in Nan’an City.Methods:Field epidemiological investigations were conducted to collect case-related information and trace the infection source.Aedes mosquito density was monitored in the core epidemic area.Whole-genome amplification and sequencing were performed on chikungunya virus(CHIKV)in the serum samples of the cases.The obtained sequences were aligned with those from GenBank,and a phylogenetic tree was constructed for viral genotypic analysis.Results:Nine days before the onset of the two local cases,an imported chikungunya case from Licheng District had received treatment at Clinic E near their residential area.Whole-genome sequencing revealed complete identity among the CHIKV strains from the two local cases and the one imported case,all belonging to the ECSA genotype.Conclusion:Epidemiological link between the locally acquired CHIKF cases in Nan’an City,Quanzhou and the imported case from Licheng District,Quanzhou.In a previously CHIKV-free nonendemic area with Aedes mosquitoes,secondary local cases may emerge approximately 9 days after the introduction of imported viremic cases.
