OBJECTIVE:To investigate the efficacy and safety of Angong Jiangya pill(AGJY,安宫降压丸)in the treatment of grade 2 hypertension with liver-fire hyperactivity syndrome.METHODS:This multicenter,randomized,double-blind,...OBJECTIVE:To investigate the efficacy and safety of Angong Jiangya pill(AGJY,安宫降压丸)in the treatment of grade 2 hypertension with liver-fire hyperactivity syndrome.METHODS:This multicenter,randomized,double-blind,placebo-controlled trial was conducted in eight medical institutions.Eligible patients with grade 2 hypertension were randomly allocated to receive AGJY or a placebo for 12 weeks.The primary outcome was the change in blood pressure(BP).The secondary outcomes were BP compliance rate,Traditional Chinese Medicine(TCM)symptoms,and Duchenne Hypertension Quality of Life Scale score.RESULTS:Data were analyzed for 117 participants in the AGJY group and 118 participants in the placebo group.After 12 weeks of treatment,AGJY compared with placebo resulted in a higher and significant reduction in systolic/diastolic BP(-15.58±10.16/-9.72±7.41 vs-8.13±8.28/-4.86±5.68 mm Hg,P<0.0001,<0.0001,respectively).BP compliance rate(31.86%vs 19.13%,P=0.027)was significantly higher in the AGJY group than in the placebo group.The AGJY group showed a significant reduction in TCM symptom score compared with the placebo group(10.82±2.03 vs 7.83±1.24,P<0.0001).Single TCM syndrome clinical control rates of the primary symptoms(dizziness,headache,and irritability)were superior in the AGJY group(71.95%,94.62%,72.53%,respectively)compared with the placebo group(48.39%,68.00%,30.52%,respectively).Scores on the Duchenne Hypertension Quality of Life Scale showed a significant increase in the AGJY group compared with the placebo group(30.65±21.06 vs 9.96±10.72,P=0.000).No serious adverse events occurred.CONCLUSION:AGJY demonstrated efficacy in lowering BP,increasing the rate of BP compliance,and improving TCM symptoms and quality of life in patients with grade 2 hypertension liver-fire hyperactivity syndrome.However,further in-depth studies are required to determine the mechanism of TCM in treating hypertension.展开更多
Objective: To compare the antihypertensive effects of tuina at Taichong (LR 3), Neiguan (PC 6) and Qiaogong (Extra) to screen the best tuina protocol for primary hypertension due to liver-fire flaming-up. Methods: A t...Objective: To compare the antihypertensive effects of tuina at Taichong (LR 3), Neiguan (PC 6) and Qiaogong (Extra) to screen the best tuina protocol for primary hypertension due to liver-fire flaming-up. Methods: A total of 102 patients with primary hypertension due to liver-fire flaming-up were randomly divided into a Taichong (LR 3) group, a Neiguan (PC 6) group and a Qiaogong (Extra) group according to the random number table, with 34 cases in each group. Patients in the three groups received 4-week tuina treatment with the corresponding acupoint respectively. The blood pressure was recorded by ben chtop mercury sphygmoma no meter before tuina, immediately after tuina treatment, 30 min and 60 min after tuina treatment with the patient in a supine position in a quiet treatment room. The total effective rate was observed. Results: The systolic and diastolic blood pressures of the three groups all decreased after treatment (all P<0.05). The decrease of systolic and diastolic blood pressure at different time points after treatment in the Qiaogong (Extra) group and the Taichong (LR 3) group were better than those in the Neiguan (PC 6) group (all P<0.05). Qiaogong (Extra) group had the highest total effective rate though there was no statistical differenee in the total effective rate among the three groups (P>0.05). Con elusion: Treati ng primary hypertensi on due to liver-fire flami ng-up with tuina at Taich ong (LR 3), Neigua n (PC 6) and Qiaogong (Extra) can reduce systolic and diastolic blood pressure respectively, among which Qiaogong (Extra) has the highest total effective rate.展开更多
Objective: To construct gene co-occurrence network of hypertension and liver-fire hyperactivity syndrome, to investigate the biological basis of hypertension and liver-fire hyperactivity syndrome and the characteristi...Objective: To construct gene co-occurrence network of hypertension and liver-fire hyperactivity syndrome, to investigate the biological basis of hypertension and liver-fire hyperactivity syndrome and the characteristics of the molecular network from gene level.Materials and Methods: Applying Gen CLip 2.0 online platform to retrieve the up-to-date literature referred to essential hypertension from PubMed database, cluster the abnormal expression of essential hypertension-related genes and analyze their function, combining Kyoto encyclopedia of genes and genomes-pathway analysis to investigate the closely related genes and the signaling molecules.Based on the genes closely related to hypertension, standard diagnostic symptoms of liver-fire hyperactivity were used as keywords to conduct hypertension liver-fire hyperactivity-related gene cluster analysis.Results: The top 1000 genes of essential hypertension were retrieved from GenCLip 2.0 online platform, which mainly clustered in the regulation of ambulatory blood pressure, regulation of renin-angiotensin-aldosterone system(RAAS), and sympathetic nervous system activity, as well as endothelial dysfunction; the closely related genes of hypertension with liver-fire hyperactivity are related to RAAS, gene REN, angiotensin converting enzyme, angiotensinogen, and cytochrome P450 family CYP2D6.Conclusion: A combination of literature mining and data mining can construct the gene network of hypertension and the syndrome-related genes, which provides a new method for the study of the biological basis of hypertension from the genetic level.展开更多
Objective To observe the clinical efficacy of acupuncture with twirling reducing method for tinnitus of excessive liver-fire type.Methods One hundred and one patients with tinnitus of excessive liver-fire type were ra...Objective To observe the clinical efficacy of acupuncture with twirling reducing method for tinnitus of excessive liver-fire type.Methods One hundred and one patients with tinnitus of excessive liver-fire type were randomly divided into a twirling reducing method group(35 cases),a needle retaining group(33 cases)and展开更多
目的探究半夏白术天麻汤联合李氏砭法虎符铜砭刮痧治疗老年肝火亢盛型高血压性眩晕(HV)的疗效。方法将2023年5月至2024年5月衡水市中医医院收治的100例老年肝火亢盛型HV患者纳入前瞻性研究,用随机数字表法将患者分为对照组(n=50)和研究...目的探究半夏白术天麻汤联合李氏砭法虎符铜砭刮痧治疗老年肝火亢盛型高血压性眩晕(HV)的疗效。方法将2023年5月至2024年5月衡水市中医医院收治的100例老年肝火亢盛型HV患者纳入前瞻性研究,用随机数字表法将患者分为对照组(n=50)和研究组(n=50)。对照组接受常规西药治疗,研究组采用常规西药+半夏白术天麻汤+李氏砭法虎符铜砭刮痧治疗,两组均持续治疗4周。比较两组的临床疗效,治疗前、治疗4周后的中医证候积分、血液流变学[红细胞聚集指数(EAI)、血小板最大聚集率(MPAR)及全血高切黏度(HBV)]及血压变异性[24 h平均收缩压(24 h mSBP)、24 h平均舒张压(24 h mDBP)、日间舒张压标准差(dDSD)、日间收缩压标准差(dSSD)、夜间舒张压标准差(nDSD)及夜间收缩压标准差(nSSD)]指标,并记录两组不良反应发生情况。结果研究组的总有效率为92.00%,显著高于对照组(76.00%),差异有统计学意义(P<0.05)。治疗4周后,两组中医证候积分均较治疗前显著下降,且研究组的眩晕、头痛目胀、易怒急躁、口苦咽干、目赤、便秘评分分别为(0.98±0.22)、(1.17±0.16)、(0.89±0.15)、(0.79±0.10)、(0.76±0.11)、(0.80±0.14)分,均显著低于对照组[(1.65±0.26)、(1.84±0.20)、(1.67±0.32)、(1.27±0.23)、(1.23±0.19)、(1.33±0.20)分],差异均有统计学意义(P<0.05)。治疗4周后,两组的ARBC、MPAR和HBV均较治疗前显著下降,且研究组的ARBC、MPAR和HBV分别为(2.56±0.57)%、(53.19±8.57)%、(5.22±0.61)mPa·s,均显著低于对照组[(3.57±0.65)%、(62.08±9.14)%、(5.79±0.67)mPa·s],差异均有统计学意义(P<0.05)。治疗4周后,两组的血压变异性指标均较治疗前显著下降,且研究组的24 h mSBP、24 h mDBP、dDSD、dSSD、nDSD和nSSD分别为(115.32±20.14)、(70.41±8.92)、(7.19±0.90)、(11.44±2.13)、(7.33±0.85)、(11.15±2.23)mmHg(1 mmHg=0.133 kpa),均显著低于对照组[(126.05±21.10)、(78.37±8.75)、(8.35±0.96)、(13.18±2.25)、(8.42±0.91)、(13.79±2.41)mmHg],差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论半夏白术天麻汤联合李氏砭法虎符铜砭刮痧治疗老年肝火亢盛型HV的疗效良好,可有效改善临床症状和血流动力学,显著降低血压及血压变异性。展开更多
基金the Program of Discipline Backbone of high-level Public Health Talents of Beijing Municipal Health Commission:Epidemiological Survey of Acute Myocardial Infarction Inpatients in Hospital of Traditional Chinese Medicine in Beijing Area(Discipline backbone-02-25)Beijing Municipal Hospital Administration Green Seedling Talent Project:Study on Characteristics of Clinical Syndromes,Status of Traditional Chinese Medicine Treatment and Prognosis of Patients with Chronic Heart Failure in Traditional Chinese Medicine Regional Health Service Center(QML20231006)。
文摘OBJECTIVE:To investigate the efficacy and safety of Angong Jiangya pill(AGJY,安宫降压丸)in the treatment of grade 2 hypertension with liver-fire hyperactivity syndrome.METHODS:This multicenter,randomized,double-blind,placebo-controlled trial was conducted in eight medical institutions.Eligible patients with grade 2 hypertension were randomly allocated to receive AGJY or a placebo for 12 weeks.The primary outcome was the change in blood pressure(BP).The secondary outcomes were BP compliance rate,Traditional Chinese Medicine(TCM)symptoms,and Duchenne Hypertension Quality of Life Scale score.RESULTS:Data were analyzed for 117 participants in the AGJY group and 118 participants in the placebo group.After 12 weeks of treatment,AGJY compared with placebo resulted in a higher and significant reduction in systolic/diastolic BP(-15.58±10.16/-9.72±7.41 vs-8.13±8.28/-4.86±5.68 mm Hg,P<0.0001,<0.0001,respectively).BP compliance rate(31.86%vs 19.13%,P=0.027)was significantly higher in the AGJY group than in the placebo group.The AGJY group showed a significant reduction in TCM symptom score compared with the placebo group(10.82±2.03 vs 7.83±1.24,P<0.0001).Single TCM syndrome clinical control rates of the primary symptoms(dizziness,headache,and irritability)were superior in the AGJY group(71.95%,94.62%,72.53%,respectively)compared with the placebo group(48.39%,68.00%,30.52%,respectively).Scores on the Duchenne Hypertension Quality of Life Scale showed a significant increase in the AGJY group compared with the placebo group(30.65±21.06 vs 9.96±10.72,P=0.000).No serious adverse events occurred.CONCLUSION:AGJY demonstrated efficacy in lowering BP,increasing the rate of BP compliance,and improving TCM symptoms and quality of life in patients with grade 2 hypertension liver-fire hyperactivity syndrome.However,further in-depth studies are required to determine the mechanism of TCM in treating hypertension.
文摘Objective: To compare the antihypertensive effects of tuina at Taichong (LR 3), Neiguan (PC 6) and Qiaogong (Extra) to screen the best tuina protocol for primary hypertension due to liver-fire flaming-up. Methods: A total of 102 patients with primary hypertension due to liver-fire flaming-up were randomly divided into a Taichong (LR 3) group, a Neiguan (PC 6) group and a Qiaogong (Extra) group according to the random number table, with 34 cases in each group. Patients in the three groups received 4-week tuina treatment with the corresponding acupoint respectively. The blood pressure was recorded by ben chtop mercury sphygmoma no meter before tuina, immediately after tuina treatment, 30 min and 60 min after tuina treatment with the patient in a supine position in a quiet treatment room. The total effective rate was observed. Results: The systolic and diastolic blood pressures of the three groups all decreased after treatment (all P<0.05). The decrease of systolic and diastolic blood pressure at different time points after treatment in the Qiaogong (Extra) group and the Taichong (LR 3) group were better than those in the Neiguan (PC 6) group (all P<0.05). Qiaogong (Extra) group had the highest total effective rate though there was no statistical differenee in the total effective rate among the three groups (P>0.05). Con elusion: Treati ng primary hypertensi on due to liver-fire flami ng-up with tuina at Taich ong (LR 3), Neigua n (PC 6) and Qiaogong (Extra) can reduce systolic and diastolic blood pressure respectively, among which Qiaogong (Extra) has the highest total effective rate.
基金supported by the National Natural Science Foundation of China (81503382), (81603499), (81473521)the National Basic Research Program of China (973 Program) under Grant No.2011CB505106scientific research project of Beijing University of Chinese Medicine (2015-JYB-JSMS036) and (2018-JYB-XJQ009)
文摘Objective: To construct gene co-occurrence network of hypertension and liver-fire hyperactivity syndrome, to investigate the biological basis of hypertension and liver-fire hyperactivity syndrome and the characteristics of the molecular network from gene level.Materials and Methods: Applying Gen CLip 2.0 online platform to retrieve the up-to-date literature referred to essential hypertension from PubMed database, cluster the abnormal expression of essential hypertension-related genes and analyze their function, combining Kyoto encyclopedia of genes and genomes-pathway analysis to investigate the closely related genes and the signaling molecules.Based on the genes closely related to hypertension, standard diagnostic symptoms of liver-fire hyperactivity were used as keywords to conduct hypertension liver-fire hyperactivity-related gene cluster analysis.Results: The top 1000 genes of essential hypertension were retrieved from GenCLip 2.0 online platform, which mainly clustered in the regulation of ambulatory blood pressure, regulation of renin-angiotensin-aldosterone system(RAAS), and sympathetic nervous system activity, as well as endothelial dysfunction; the closely related genes of hypertension with liver-fire hyperactivity are related to RAAS, gene REN, angiotensin converting enzyme, angiotensinogen, and cytochrome P450 family CYP2D6.Conclusion: A combination of literature mining and data mining can construct the gene network of hypertension and the syndrome-related genes, which provides a new method for the study of the biological basis of hypertension from the genetic level.
文摘Objective To observe the clinical efficacy of acupuncture with twirling reducing method for tinnitus of excessive liver-fire type.Methods One hundred and one patients with tinnitus of excessive liver-fire type were randomly divided into a twirling reducing method group(35 cases),a needle retaining group(33 cases)and
文摘目的探究半夏白术天麻汤联合李氏砭法虎符铜砭刮痧治疗老年肝火亢盛型高血压性眩晕(HV)的疗效。方法将2023年5月至2024年5月衡水市中医医院收治的100例老年肝火亢盛型HV患者纳入前瞻性研究,用随机数字表法将患者分为对照组(n=50)和研究组(n=50)。对照组接受常规西药治疗,研究组采用常规西药+半夏白术天麻汤+李氏砭法虎符铜砭刮痧治疗,两组均持续治疗4周。比较两组的临床疗效,治疗前、治疗4周后的中医证候积分、血液流变学[红细胞聚集指数(EAI)、血小板最大聚集率(MPAR)及全血高切黏度(HBV)]及血压变异性[24 h平均收缩压(24 h mSBP)、24 h平均舒张压(24 h mDBP)、日间舒张压标准差(dDSD)、日间收缩压标准差(dSSD)、夜间舒张压标准差(nDSD)及夜间收缩压标准差(nSSD)]指标,并记录两组不良反应发生情况。结果研究组的总有效率为92.00%,显著高于对照组(76.00%),差异有统计学意义(P<0.05)。治疗4周后,两组中医证候积分均较治疗前显著下降,且研究组的眩晕、头痛目胀、易怒急躁、口苦咽干、目赤、便秘评分分别为(0.98±0.22)、(1.17±0.16)、(0.89±0.15)、(0.79±0.10)、(0.76±0.11)、(0.80±0.14)分,均显著低于对照组[(1.65±0.26)、(1.84±0.20)、(1.67±0.32)、(1.27±0.23)、(1.23±0.19)、(1.33±0.20)分],差异均有统计学意义(P<0.05)。治疗4周后,两组的ARBC、MPAR和HBV均较治疗前显著下降,且研究组的ARBC、MPAR和HBV分别为(2.56±0.57)%、(53.19±8.57)%、(5.22±0.61)mPa·s,均显著低于对照组[(3.57±0.65)%、(62.08±9.14)%、(5.79±0.67)mPa·s],差异均有统计学意义(P<0.05)。治疗4周后,两组的血压变异性指标均较治疗前显著下降,且研究组的24 h mSBP、24 h mDBP、dDSD、dSSD、nDSD和nSSD分别为(115.32±20.14)、(70.41±8.92)、(7.19±0.90)、(11.44±2.13)、(7.33±0.85)、(11.15±2.23)mmHg(1 mmHg=0.133 kpa),均显著低于对照组[(126.05±21.10)、(78.37±8.75)、(8.35±0.96)、(13.18±2.25)、(8.42±0.91)、(13.79±2.41)mmHg],差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论半夏白术天麻汤联合李氏砭法虎符铜砭刮痧治疗老年肝火亢盛型HV的疗效良好,可有效改善临床症状和血流动力学,显著降低血压及血压变异性。
