Objective： To explore the brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening post-traumatic stress disorder（PTSD）.Methods： According to random number table m...Objective： To explore the brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening post-traumatic stress disorder（PTSD）.Methods： According to random number table method, 60 SD rats were randomly divided into blank group, model group, grabbing group, paroxetine group and acupuncture group. Except for the blank group, all the rats were established into PTSD models through electric shock and incarceration, with model replication for 7 days in total. The rats were given gavage, acupuncture intervention and grabbing fixation 1 h before modeling, with 6 days as 1 course of treatment. Grabbing treatment was performed for 2 courses, with 12 days in total. After modeling, functional near-infrared spectroscopy（fNIRS） system was adopted to collect and record the changes of concentration of Oxy-Hb, Deoxy-Hb and Total-Hb during 3 min in related brain regions of rats in each group after treatment for 5 consecutive days, and the brain function was evaluated.Results： According to the comparison of the time series of blood-oxygen concentration, there were significant differences between model group and blank group as well as grabbing group and blank group（P〈0.01, P〈0.01）, no significant difference was found between model group and grabbing group（P〈0.05）; there were significant differences between paroxetine group and grabbing group as well as acupuncture group and grabbing group（P〈0.05, P〈0.05）, no significant difference was found between paroxetine group and acupuncture group（P〈0.05）.Conclusion： ＂Liver-soothing and mind-regulating＂ acupuncture manipulation has a benign regulatory effect on the blood-oxygen concentration in cerebral cortex of PTSD rats, which may be the important brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening PTSD.展开更多
Objective To observe the efficacy of Shugan Tiaoshen(liver-soothing and mind-regulating)needling method in the treatment of patients with postherpetic neuralgia(PHN).Methods A total of 66 patients with PHN were random...Objective To observe the efficacy of Shugan Tiaoshen(liver-soothing and mind-regulating)needling method in the treatment of patients with postherpetic neuralgia(PHN).Methods A total of 66 patients with PHN were randomly divided into acupuncture group and control group,33 cases in each one,by the random number table method.The acupuncture group received Shugan Tiaoshen needling method plus gabapentin,whereas the control group received the oral administration of gabapentin and sham acupuncture.Numerical Rating Scale(NRS),State-Trait Anxiety Inventory(STAI)and Pittsburgh Sleep Quality Index(PSQI)were used to evaluate the pain condition,anxiety symptom and sleep quality.The effective rate and adverse events were also evaluated and recorded during the treatment.Results After eight weeks of treatment,the NRS scores of the two groups were significantly lower than those before treatment(P<0.05)at all time points,with statistically significant difference between the groups(P<0.05).The scores of STAI and PSQI of the acupuncture group were significantly lower than the scores before treatment(P<0.05).The scores of STAI for anxiety symptom and PSQI of the acupuncture group were significantly lower than the control group(P<0.05),and the effective rate of the acupuncture group was significantly higher than that of the control group(P<0.05).The incidence of adverse reactions in the acupuncture group was significantly lower than that in the control group(P<0.05).Conclusion Shugan Tiaoshen needling method showed satisfactory efficacy in treating PHN,and could alleviate the pain,relieve the anxiety symptoms,promote sleep,and reduce the adverse reactions of gabapentin in patients with PHN.展开更多
The pattern of disharmony between the liver and stomach is widely observed in patients with digestive diseases,such as gastroesophageal reflux disease,chronic gastritis,and functional dyspepsia,etc.In order to gain a ...The pattern of disharmony between the liver and stomach is widely observed in patients with digestive diseases,such as gastroesophageal reflux disease,chronic gastritis,and functional dyspepsia,etc.In order to gain a full and systematic understanding of this pattern,we reviewed the functions and physiological characteristics of the liver and stomach and the liver-stomach relationship.In this review,we discuss the pathogenesis and identification of the pattern,as well as the commonly used classical formulas for its treatment,including Left Metal Pill (Zuojin Wan) and Bupleurum Liver-Soothing Powder (Chaihu Shugan San).Besides,we provide two examples of clinical modifications of these formulas in the treatment of chronic gastritis and gastroesophageal reflux disease in this article.It should be noted that in clinical practice,these formulas should be used flexibly,and modified in accordance to the specific condition of the patient.展开更多
基金Supported by Regional fund project of 2014 National Natural Science Foundation of China:814607442013 Gansu Provincial Natural Science Foundation:1308RJZA150~~
文摘Objective： To explore the brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening post-traumatic stress disorder（PTSD）.Methods： According to random number table method, 60 SD rats were randomly divided into blank group, model group, grabbing group, paroxetine group and acupuncture group. Except for the blank group, all the rats were established into PTSD models through electric shock and incarceration, with model replication for 7 days in total. The rats were given gavage, acupuncture intervention and grabbing fixation 1 h before modeling, with 6 days as 1 course of treatment. Grabbing treatment was performed for 2 courses, with 12 days in total. After modeling, functional near-infrared spectroscopy（fNIRS） system was adopted to collect and record the changes of concentration of Oxy-Hb, Deoxy-Hb and Total-Hb during 3 min in related brain regions of rats in each group after treatment for 5 consecutive days, and the brain function was evaluated.Results： According to the comparison of the time series of blood-oxygen concentration, there were significant differences between model group and blank group as well as grabbing group and blank group（P〈0.01, P〈0.01）, no significant difference was found between model group and grabbing group（P〈0.05）; there were significant differences between paroxetine group and grabbing group as well as acupuncture group and grabbing group（P〈0.05, P〈0.05）, no significant difference was found between paroxetine group and acupuncture group（P〈0.05）.Conclusion： ＂Liver-soothing and mind-regulating＂ acupuncture manipulation has a benign regulatory effect on the blood-oxygen concentration in cerebral cortex of PTSD rats, which may be the important brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening PTSD.
基金Supported by the project on the management of TCM in Guangdong Province:No.20231213Key Construction Project of TCM Discipline of Guangdong Pharmaceutical University:No.2022-8.
文摘Objective To observe the efficacy of Shugan Tiaoshen(liver-soothing and mind-regulating)needling method in the treatment of patients with postherpetic neuralgia(PHN).Methods A total of 66 patients with PHN were randomly divided into acupuncture group and control group,33 cases in each one,by the random number table method.The acupuncture group received Shugan Tiaoshen needling method plus gabapentin,whereas the control group received the oral administration of gabapentin and sham acupuncture.Numerical Rating Scale(NRS),State-Trait Anxiety Inventory(STAI)and Pittsburgh Sleep Quality Index(PSQI)were used to evaluate the pain condition,anxiety symptom and sleep quality.The effective rate and adverse events were also evaluated and recorded during the treatment.Results After eight weeks of treatment,the NRS scores of the two groups were significantly lower than those before treatment(P<0.05)at all time points,with statistically significant difference between the groups(P<0.05).The scores of STAI and PSQI of the acupuncture group were significantly lower than the scores before treatment(P<0.05).The scores of STAI for anxiety symptom and PSQI of the acupuncture group were significantly lower than the control group(P<0.05),and the effective rate of the acupuncture group was significantly higher than that of the control group(P<0.05).The incidence of adverse reactions in the acupuncture group was significantly lower than that in the control group(P<0.05).Conclusion Shugan Tiaoshen needling method showed satisfactory efficacy in treating PHN,and could alleviate the pain,relieve the anxiety symptoms,promote sleep,and reduce the adverse reactions of gabapentin in patients with PHN.
文摘The pattern of disharmony between the liver and stomach is widely observed in patients with digestive diseases,such as gastroesophageal reflux disease,chronic gastritis,and functional dyspepsia,etc.In order to gain a full and systematic understanding of this pattern,we reviewed the functions and physiological characteristics of the liver and stomach and the liver-stomach relationship.In this review,we discuss the pathogenesis and identification of the pattern,as well as the commonly used classical formulas for its treatment,including Left Metal Pill (Zuojin Wan) and Bupleurum Liver-Soothing Powder (Chaihu Shugan San).Besides,we provide two examples of clinical modifications of these formulas in the treatment of chronic gastritis and gastroesophageal reflux disease in this article.It should be noted that in clinical practice,these formulas should be used flexibly,and modified in accordance to the specific condition of the patient.
