To the Editor：We read with tremendous interest the paper by Del Fabbroet al. [1]. In this thorough article, the authors meticulously underlinethe advantages of a modified j-shaped incision for the simultaneoustreatme...To the Editor：We read with tremendous interest the paper by Del Fabbroet al. [1]. In this thorough article, the authors meticulously underlinethe advantages of a modified j-shaped incision for the simultaneoustreatment of difficult liver colorectal metastases （CRM） and right-lung CRM, reporting their experience in a cohort of 11 patients.展开更多
As a kind of well-known edible mushroom,the medicinal values of Agaricus blazei Murill also have been well acknowledged.There is no efficient treatment strategy for multiple organ dysfunction syndrome (MODS) so far,a ...As a kind of well-known edible mushroom,the medicinal values of Agaricus blazei Murill also have been well acknowledged.There is no efficient treatment strategy for multiple organ dysfunction syndrome (MODS) so far,a crucial cause of clinical death.The present work was designed to evaluate the beneficially protective effects of Agaricus blazei Murill polysaccharides (ABMP) on liver and lung against zymosan (ZY)-induced MODS related damages.The MODS mice were successfully established by given one-time injection of zymosan solution (500 mg/kg) intraperitoneally.The in vivo results demonstrated that ABMP could improve the 10-day survival rate,ease abnormal physiological behavior and alleviate tissues oxidative stress in MODS mice.Besides,ABMP showed potential effects on attenuating the functional impairments of liver and lung.Meanwhile,ABMP effectively inhibited the activation of NF-κB signaling pathway and reduced the expressions of inflammatory cytokines,including TNF-α,IL-1β,IL-6,COX-2 and PGE-2.Additionally,the structural characterizations showed that the significant function of ABMP was possibly related with the β-pyranose configuration with a triple-helical structure composing of glucose mainly with the proper molecular weights of 12.26 kDa.These findings demonstrated that ABMP exhibited potential protections against liver and lung damages in the ZY-induced MODS mice,providing more theoretical basis and reference significance for the exploration of biological activity of A.blazei Murill.展开更多
The Author Reply：We thank Dr. Sucameli et al. for the interest toward our article[1] and for the opportunity for further discussing on this issue,providing a case report of single metastastic fore sites in the livera...The Author Reply：We thank Dr. Sucameli et al. for the interest toward our article[1] and for the opportunity for further discussing on this issue,providing a case report of single metastastic fore sites in the liverand lung both treated in a minimal access fashion. However, giventhe interest of the authors insight, it appears misleading when related to that discussed in our report which was clearly referred toother patients＇ profiles. Indeed, they described a case with a singleperipheral nodule in the right lung and a single liver metastasesin segment 5. This uncommon situation （less than 2% of patientsaccording to the LiverMetSurvey registry [2]）, is obviouslya more than reasonable indication for a mini-invasive approach.However, our patients received surgery for complex oncological involvementof the liver： as described, this means large and/or multiplelesions, in contact or invading the hepatic veins at caval confluence.For such conditions we have introduced original surgicalapproaches [3,4]： in such conditions we would select a J-shapedthoracophrenolaparotomy for the liver per se [5]. This incision forsuch complex conditions other than allowing the liver clearance in a single operation rather than in staged approach [6], allows justin case the removal of lung nodules. Therefore, we thank again theauthors for their interest to our report, and furthermore we congratulatefor the original management of the shared clinical case.However, the condition recalled by the authors is related to a scenariooncologically and surgically at the opposite side of that discussedin our paper and for that somehow suggesting a comparisonis misleading.展开更多
文摘To the Editor：We read with tremendous interest the paper by Del Fabbroet al. [1]. In this thorough article, the authors meticulously underlinethe advantages of a modified j-shaped incision for the simultaneoustreatment of difficult liver colorectal metastases （CRM） and right-lung CRM, reporting their experience in a cohort of 11 patients.
基金supported by grants from Mushroom Technology System of Shandong Province(SDAIT-07-05)China Postdoctoral Science Foundation funded project(2019M660163).
文摘As a kind of well-known edible mushroom,the medicinal values of Agaricus blazei Murill also have been well acknowledged.There is no efficient treatment strategy for multiple organ dysfunction syndrome (MODS) so far,a crucial cause of clinical death.The present work was designed to evaluate the beneficially protective effects of Agaricus blazei Murill polysaccharides (ABMP) on liver and lung against zymosan (ZY)-induced MODS related damages.The MODS mice were successfully established by given one-time injection of zymosan solution (500 mg/kg) intraperitoneally.The in vivo results demonstrated that ABMP could improve the 10-day survival rate,ease abnormal physiological behavior and alleviate tissues oxidative stress in MODS mice.Besides,ABMP showed potential effects on attenuating the functional impairments of liver and lung.Meanwhile,ABMP effectively inhibited the activation of NF-κB signaling pathway and reduced the expressions of inflammatory cytokines,including TNF-α,IL-1β,IL-6,COX-2 and PGE-2.Additionally,the structural characterizations showed that the significant function of ABMP was possibly related with the β-pyranose configuration with a triple-helical structure composing of glucose mainly with the proper molecular weights of 12.26 kDa.These findings demonstrated that ABMP exhibited potential protections against liver and lung damages in the ZY-induced MODS mice,providing more theoretical basis and reference significance for the exploration of biological activity of A.blazei Murill.
文摘The Author Reply：We thank Dr. Sucameli et al. for the interest toward our article[1] and for the opportunity for further discussing on this issue,providing a case report of single metastastic fore sites in the liverand lung both treated in a minimal access fashion. However, giventhe interest of the authors insight, it appears misleading when related to that discussed in our report which was clearly referred toother patients＇ profiles. Indeed, they described a case with a singleperipheral nodule in the right lung and a single liver metastasesin segment 5. This uncommon situation （less than 2% of patientsaccording to the LiverMetSurvey registry [2]）, is obviouslya more than reasonable indication for a mini-invasive approach.However, our patients received surgery for complex oncological involvementof the liver： as described, this means large and/or multiplelesions, in contact or invading the hepatic veins at caval confluence.For such conditions we have introduced original surgicalapproaches [3,4]： in such conditions we would select a J-shapedthoracophrenolaparotomy for the liver per se [5]. This incision forsuch complex conditions other than allowing the liver clearance in a single operation rather than in staged approach [6], allows justin case the removal of lung nodules. Therefore, we thank again theauthors for their interest to our report, and furthermore we congratulatefor the original management of the shared clinical case.However, the condition recalled by the authors is related to a scenariooncologically and surgically at the opposite side of that discussedin our paper and for that somehow suggesting a comparisonis misleading.
