As a biopic focusing on the people’s writer Liu Qing,the movie Liu Qing shows the creative process of Liu Qing’s rooting in the countryside and sharing the fate of peasants through the fusion of realist aesthetics a...As a biopic focusing on the people’s writer Liu Qing,the movie Liu Qing shows the creative process of Liu Qing’s rooting in the countryside and sharing the fate of peasants through the fusion of realist aesthetics and poetic expression.Contemporary writer’s biography movie is almost blank in the domestic movie history due to its special subject matter.The creation of Liu Qing required balancing the tension between historical truth,artistic aesthetics,and policy scrutiny.By deconstructing the multiple identities of the writer,reconstructing the logic of vernacular narrative,and exploring the innovation of melodramatic genre,the director has created the image of a people’s writer rooted in the earth.Combining the perspective of director Tian Bo,this article discusses how to construct a writer’s image on the screen with both depth of thought and humanistic temperature,and reveals the revelation of Liu Qing’s spirit to contemporary literary creation.展开更多
On 18 December 2024,Liu Hongcai,Vice-President of CAFIU met with Seiji Yamamoto,Director General of the Broad National Alliance for Independence,Peace and Democracy of Japan.The two sides exchanged views on China-Japa...On 18 December 2024,Liu Hongcai,Vice-President of CAFIU met with Seiji Yamamoto,Director General of the Broad National Alliance for Independence,Peace and Democracy of Japan.The two sides exchanged views on China-Japan relations,people-to-people exchanges and cooperation between the two organisations.展开更多
Premature ovarian failure(POF)is a prevalent gynecological disorder with significant implications for the physical and mental well-being of affected individuals.Liu Wei Di Huang Wan(LWDHW),a Chinese herbal compound,ha...Premature ovarian failure(POF)is a prevalent gynecological disorder with significant implications for the physical and mental well-being of affected individuals.Liu Wei Di Huang Wan(LWDHW),a Chinese herbal compound,has demonstrated efficacy in alleviating the effects of POF.However,the underlying mechanism of action of LWDHW remains unclear.This study aimed to elucidate the potential molecular mechanism of LWDHW in treating POF using network pharmacology and molecular docking techniques.The active ingredients of LWDHW were initially screened through the TCMSP platform.At the same time,the relevant target genes associated with POF were identified using databases such as Disgenet,TTD,Drugbank,Gene Cards,OMIM,and Pharm GKB.Data analysis was conducted using the R language,Cytoscape,and STRING to construct and analyze the traditional Chinese medicine(TCM)regulatory network and protein-protein interaction(PPI)network maps.Subsequently,GO and KEGG enrichment analyses were performed using the R language.Finally,molecular docking was carried out between the protein receptors of the core genes and the corresponding small-molecule ligands.The study revealed 49 components and 189 predicted targets(after de-duplication)of LWDHW,along with 4524 targets(after de-duplication)associated with POF.Through comparative analysis,163 potential genes were identified as common targets of LWDHW and POF,participating in biological processes such as response to chemical substances,molecular function regulation,and signaling receptor binding.Key biological pathways implicated included the MAPK signaling pathway,IL-17 signaling pathway,and HIF-1 signaling pathway,among others.Molecular docking results demonstrated a robust binding ability between the core genes of LWDHW and their corresponding ingredients.In conclusion,this comprehensive analysis provided insights into the potential molecular mechanisms of LWDHW in treating POF.The identified common targets and associated pathways contributed to our understanding of how LWDHW exerted its therapeutic effects,paving the way for further research and clinical applications.It is worth noting that future studies with experimental validation and clinical trials are essential to confirm these findings and establish the safety and efficacy of LWDHW in the treatment of POF.展开更多
利用三阶混沌系统构造了一种新的微弱信号检测系统——类Liu系统,对类Liu系统进行了深度的理论分析.类Liu系统中,当输入待测信号幅值大于某临界值时,系统可达到平衡点S0,S0中系统变量x平衡于摄动力信号,系统变量y,z收敛于零态,且S0对应...利用三阶混沌系统构造了一种新的微弱信号检测系统——类Liu系统,对类Liu系统进行了深度的理论分析.类Liu系统中,当输入待测信号幅值大于某临界值时,系统可达到平衡点S0,S0中系统变量x平衡于摄动力信号,系统变量y,z收敛于零态,且S0对应的Lyapunov指数小于零.通过Matlab仿真、Multisim电路仿真以及实际电路证明了类Liu系统的周期态收敛性及广域检测性,解决了传统Duffing系统进行微弱信号检测时周期态不收敛、只能进行窄域检测等问题,同时谱级信噪比范围仍可达-46.57 d B.类Liu系统采用了全新的设计理念,具有较高的实用价值,对未来海洋物联网中的水声通信有一定参考价值.展开更多
文摘As a biopic focusing on the people’s writer Liu Qing,the movie Liu Qing shows the creative process of Liu Qing’s rooting in the countryside and sharing the fate of peasants through the fusion of realist aesthetics and poetic expression.Contemporary writer’s biography movie is almost blank in the domestic movie history due to its special subject matter.The creation of Liu Qing required balancing the tension between historical truth,artistic aesthetics,and policy scrutiny.By deconstructing the multiple identities of the writer,reconstructing the logic of vernacular narrative,and exploring the innovation of melodramatic genre,the director has created the image of a people’s writer rooted in the earth.Combining the perspective of director Tian Bo,this article discusses how to construct a writer’s image on the screen with both depth of thought and humanistic temperature,and reveals the revelation of Liu Qing’s spirit to contemporary literary creation.
文摘On 18 December 2024,Liu Hongcai,Vice-President of CAFIU met with Seiji Yamamoto,Director General of the Broad National Alliance for Independence,Peace and Democracy of Japan.The two sides exchanged views on China-Japan relations,people-to-people exchanges and cooperation between the two organisations.
基金Science and Technology Commission Joint Traditional Chinese Medicine Project of Chongqing,China(Grant No.2023MSXM166)。
文摘Premature ovarian failure(POF)is a prevalent gynecological disorder with significant implications for the physical and mental well-being of affected individuals.Liu Wei Di Huang Wan(LWDHW),a Chinese herbal compound,has demonstrated efficacy in alleviating the effects of POF.However,the underlying mechanism of action of LWDHW remains unclear.This study aimed to elucidate the potential molecular mechanism of LWDHW in treating POF using network pharmacology and molecular docking techniques.The active ingredients of LWDHW were initially screened through the TCMSP platform.At the same time,the relevant target genes associated with POF were identified using databases such as Disgenet,TTD,Drugbank,Gene Cards,OMIM,and Pharm GKB.Data analysis was conducted using the R language,Cytoscape,and STRING to construct and analyze the traditional Chinese medicine(TCM)regulatory network and protein-protein interaction(PPI)network maps.Subsequently,GO and KEGG enrichment analyses were performed using the R language.Finally,molecular docking was carried out between the protein receptors of the core genes and the corresponding small-molecule ligands.The study revealed 49 components and 189 predicted targets(after de-duplication)of LWDHW,along with 4524 targets(after de-duplication)associated with POF.Through comparative analysis,163 potential genes were identified as common targets of LWDHW and POF,participating in biological processes such as response to chemical substances,molecular function regulation,and signaling receptor binding.Key biological pathways implicated included the MAPK signaling pathway,IL-17 signaling pathway,and HIF-1 signaling pathway,among others.Molecular docking results demonstrated a robust binding ability between the core genes of LWDHW and their corresponding ingredients.In conclusion,this comprehensive analysis provided insights into the potential molecular mechanisms of LWDHW in treating POF.The identified common targets and associated pathways contributed to our understanding of how LWDHW exerted its therapeutic effects,paving the way for further research and clinical applications.It is worth noting that future studies with experimental validation and clinical trials are essential to confirm these findings and establish the safety and efficacy of LWDHW in the treatment of POF.
文摘利用三阶混沌系统构造了一种新的微弱信号检测系统——类Liu系统,对类Liu系统进行了深度的理论分析.类Liu系统中,当输入待测信号幅值大于某临界值时,系统可达到平衡点S0,S0中系统变量x平衡于摄动力信号,系统变量y,z收敛于零态,且S0对应的Lyapunov指数小于零.通过Matlab仿真、Multisim电路仿真以及实际电路证明了类Liu系统的周期态收敛性及广域检测性,解决了传统Duffing系统进行微弱信号检测时周期态不收敛、只能进行窄域检测等问题,同时谱级信噪比范围仍可达-46.57 d B.类Liu系统采用了全新的设计理念,具有较高的实用价值,对未来海洋物联网中的水声通信有一定参考价值.
