University campus is the most important place for life, study, activity and experience of contemporary college students. It is helpful for students to survive and develop to create the topic space of campus. Taking th...University campus is the most important place for life, study, activity and experience of contemporary college students. It is helpful for students to survive and develop to create the topic space of campus. Taking the topic space of college campuses in Lishui City of Zhejiang Province as an example, the current situations are analyzed through questionnaire survey and field visit. The results show that uni- versity campus space needs a clear topic; the demands are generally large for the topics of exchange and communication, learning and thinking, sports and leisure in all kinds of space; the creation of these types of topic spaces should focus on the peaceful environment, beautiful scenery, privacy of the space and WlFI coverage.展开更多
The current development of Lishui tourist transport center is introduced,its forming reason and current problems are analyzed,finally its strengthening strategy is proposed.
A new genus and species of nodosaurid dinosaur： Zhejiangosaurus lishuiensis gen. et sp. nov. is erected herein. It is characterized by the sacrum consisting of at least three true sacral vertebrae, 5 caudal dorsal ve...A new genus and species of nodosaurid dinosaur： Zhejiangosaurus lishuiensis gen. et sp. nov. is erected herein. It is characterized by the sacrum consisting of at least three true sacral vertebrae, 5 caudal dorsal vertebrae fused to form the presacral rod, wide divergence of long slender preacetabular process of the ilium from the middle line of the body, and the fourth trochanter located at the femoral mid-length.展开更多
The Lishui Sag, in the East China Sea Shelf Basin, is rich in hydrocarbons, with the major hydrocarbon-bearing layers being the Paleocene Mingyuefeng clastic rocks. Analysis of the implicit geologic background informa...The Lishui Sag, in the East China Sea Shelf Basin, is rich in hydrocarbons, with the major hydrocarbon-bearing layers being the Paleocene Mingyuefeng clastic rocks. Analysis of the implicit geologic background information of these Paleocene clastic rocks using petrological and geochemical methods has significant practical importance. These Paleocene sandstones are mainly lithic arenite, lithic arkose and greywacke, composed of K-feldspar, plagioclase, authigenic clays, silica and carbonates. As continental deposits, Yueguifeng clastic rocks have high aluminosilicate and mafic detritus contents, while the Lingfeng and Mingyuefeng Formations are rich in silica due to an oscillating coastal marine depositional environment. The major element contents of these Paleocene sandstones are low and have a concentrated distribution, indicating that the geochemical composition is non-epigenetic, transformed by sedimentary processes and diagenesis. The Yueguifeng detritus comprises recycled sediments, controlled by moderate weathering and erosion, while the Lingfeng and Mingyuefeng detritus is interpreted as primarily first-cycle materials due to low chemical weathering. In the Late Cretaceous to Early Paleocene, the Pacific Plate began subducting under the Eurasian Plate, causing an orogeny by plate collision and magma eruption due to the melting of subducted oceanic crust. This resulted in the dual tectonic settings of ＂active margin＂ and ＂continental island arc＂ in the East China Sea Shelf Basin. During the Late Paleocene, the Pacific Plate margin migrated eastward along with development of the Philippine Ocean Plate, and the tectonic setting of the Lishui Sag gradually turned into a passive continental margin. Detrital sources included both orogenic continental blocks and continental island arcs, and the parent rocks are primarily felsic volcanic rocks and granites.展开更多
The restoration of the denudation thickness is the basis for quantitatively analyzing the basin burial history,thermal evolution history and hydrocarbon accumulation conditions.The well data is not sufficient to do th...The restoration of the denudation thickness is the basis for quantitatively analyzing the basin burial history,thermal evolution history and hydrocarbon accumulation conditions.The well data is not sufficient to do this in the southern Lishui Sag with only 5 wells,so the new,high-quality three-dimensional(3D)seismic data is essential.The methods employed to determine the eroded thicknesses of key unconformities in the study area are the mudstone acoustic time difference(AC)method,vitrinite reflectance(Ro%)method and stratigraphic trend comparison method.On the basis of the structural evolution,the restoration of the paleogeomorphology is carried out.The results show that the Wenzhou formation(E2 w)in the entire study area has been all denuded.The denudation thickness is in the range of 0–550 m,and decreases gradually from west,thicker than 200 m,to east.The erosion of the upper Lingfeng formation(E1l)are mainly occurred in the N-P-1 structural trap(N-P-1),the N-P-2 structural trap(N-P-2)and the N-P-3 structural trap(N-P-3).Among them,the eroded area in N-P-1(near well S-1)and N-P-2 is 200–230 km^2,and the denudation thickness is 0–600 m,which increases from south to north,even up to 200–400 m in the region around well S-1.In N-P-3,the extent of denudation is 30–50 km^2,and the denudation thickness is 0–400 m.In the early stage of the upper E1 l,one north-south strike slip fault began to develop in the southern study area.Affected by this fault,the southern Lingfeng bulge was offset,forming a gorge,and the eastern and western sides of the concave belt connected to each other.On the basis of the paleo-geomorphological characteristics,it is shown that the sedimentary center of the west subsag began to migrate to the south.展开更多
In this study, the differences in reservoir parameters, such as pore radius, throat radius, and pore-throat ratio, between the east and west subsags of the Lishui Sag are analyzed by using data obtained from a constan...In this study, the differences in reservoir parameters, such as pore radius, throat radius, and pore-throat ratio, between the east and west subsags of the Lishui Sag are analyzed by using data obtained from a constant-rate mercury injection experiment. Furthermore, the quality of the reservoirs in the two subsags is systematically evaluated. Results show that the throat radius of the Lishui west subsag is larger than that of the east subsag, and this parameter has a positive correlation with reservoir quality. However, the pore-throat ratio of the east subsag is larger than that of the west subsag, which has an inverse relationship with reservoir quality. The main reasons for this reservoir difference can be attributed to sedimentation and diagenesis. The sedimentary facies types of the Lishui east subsag are the fan delta, shore lake, shallow lake, and shore shallow lake;their sandstone composition maturity is low;the clay mineral content is high;and the rock has undergone strong diagenesis. Therefore, the physical conditions of the reservoir are poor. However, the sandstones in the Lishui west subsag have weak cementation and compaction, mainly with an intergranular pore structure type, which leads to good connectivity between pores. Therefore, the storage performance and seepage capacity of the Lishui west subsag are better than those of the east subsag;the west subsag is the main area of oil and gas accumulation, as confirmed in the process of exploration and development.展开更多
OBJECTIVE: To investigate a possible mechanism for protective effects of a decoction of the Qinggan Lishui formula(QF) on retinal ganglion cells(RGCs)in a rat model of microbead-induced chronic intraocular hypertensio...OBJECTIVE: To investigate a possible mechanism for protective effects of a decoction of the Qinggan Lishui formula(QF) on retinal ganglion cells(RGCs)in a rat model of microbead-induced chronic intraocular hypertension(COH).METHODS: The COH model was generated by injecting microbeads(superparamagnetic iron oxide)into the anterior chamber of rat eyes. QF was given by intragastric administration(gavage) once daily at a dose of 6.2 g/kg until day 28, following microbead injection. Cholera toxin B subunit(CTB) retrograde labeling and immunohistochemistry were used to evaluate changes in the number of RGCs in the retina. Terminal d UTP nick end labeling(TUNEL) staining was used to assess apoptotic changes in RGCs.RESULTS: Microbead injection induced a steady increase in intraocular pressure(IOP) of rats. Elevated IOP resulted in a progressive reduction in the number of CTB-labeled RGCs, 2-4 weeks after microbead injection. QF administration may moderately reduce IOP in the rat COH model and attenuate reduction of the number of CTB-labeled RGCs in COH rats. Furthermore, elevated IOP resulted in a progressive increase in the number of TUNEL-positive RGCs, 2-4 weeks after microbead injection, suggestive of an increase in the extent of RGC apoptosis.There was a significant reduction in the number of TUNEL-positive signals in QF-treated COH retinas,compared with untreated COH retinas.CONCLUSION: QF decoction may provide a protective effect for RGCs in COH retinas by reducing RGC loss; these effects may be mediated by inhibition of RGC apoptosis.展开更多
Estimation of base level changes in geological records is an important topic for petroleum geologists.Taking the Paleocene Upper Lingfeng Member of Lishui Sag as an example,this paper conducted a base level reconstruc...Estimation of base level changes in geological records is an important topic for petroleum geologists.Taking the Paleocene Upper Lingfeng Member of Lishui Sag as an example,this paper conducted a base level reconstruction based on Basin Filling Modelling(BFM).The reconstruction was processed on the ground of a previously interpreted seismic stratigraphic framework with several assumptions and simplification.The BFM is implemented with a nonlinear diffusion equation solver written in R coding that excels in shallow marine stratigraphic simulation.The modeled results fit the original stratigraphy very well.The BFM is a powerful tool for reconstructing the base level,and is an effective way to check the reasonableness of previous interpretations.Although simulation solutions may not be unique,the BFM still provides us a chance to gain some insights into the mechanism and dynamic details of the stratigraphy of sedimentary basins.展开更多
The East China Sea Shelf Basin generated a series of back-arc basins with thick successions of marine-and terrestrial-facies sediments during Cenozoic.It is enriched with abundant oil and gas resources and is of great...The East China Sea Shelf Basin generated a series of back-arc basins with thick successions of marine-and terrestrial-facies sediments during Cenozoic.It is enriched with abundant oil and gas resources and is of great significance to the petroleum exploration undertakings.Therein,the Lishui Sag formed fan delta,fluvial delta and littoral-to-neritic facies sediments during Paleocene–Eocene,and the research on its sedimentary environment and sediment source was controversial.This study analyzed the paleontological combination characteristics,and conducted a source-to-sink comparative analysis to restore the sedimentary environment and provenance evolution of the Lishui Sag during Paleocene–Eocene based on the integration of detrital zircon U-Pb age spectra patterns with paleontological assemblages.The results indicated that Lishui Sag was dominated by littoral and neritic-facies environment during time corroborated by large abundance of foraminifera,calcareous nannofossils and dinoflagellates.Chronological analysis of detrital zircon U-Pb revealed that there were significant differences in sediment sources between the east and west area of the Lishui Sag.The western area was featured by deeper water depths in the Paleocene–Eocene,and the sediment was characterized by a single Yanshanian peak of zircon U-Pb age spectra,and mainly influenced from Yanshanian magmatic rocks of South China Coast and the surrounding paleo-uplifts.However,its eastern area partly showed Indosinian populations.In particular,the upper Eocene Wenzhou sediments were featured by increasingly plentiful Precambrian zircons in addition to the large Indosinian-Yanshanian peaks,indicating a possible impact from the Yushan Low Uplift to the east.Therefore,it is likely that the eastern Lishui Sag generated large river systems as well as deltas during time.Due to the Yuquan Movement,the Lishui Sag experienced uplifting and exhumation in the late stage of the late Eocene and was not deposited with sediments until Miocene.Featured by transitional-facies depositions of Paleocene–Eocene,the Lishui Sag thus beared significant potential for source rock and oil-gas reservoir accumulation.展开更多
Objective:To investigate the effect of Jianshen Lishui decoction on C-reactive protein and Procalcitonin in patients with acute Cerebral Hemorrhage.Methods:120 patients with acute spontaneous Cerebral Hemorrhage were ...Objective:To investigate the effect of Jianshen Lishui decoction on C-reactive protein and Procalcitonin in patients with acute Cerebral Hemorrhage.Methods:120 patients with acute spontaneous Cerebral Hemorrhage were randomly divided into two groups:Control Group and the Observation Group.The Control Group was treated with routine Western medicine.The Observation Group was treated with Jianshen Lishui decoction on the basis of the Control Group.The observation period was 4 weeks,the changes of nerve function,C-reactive protein and Procalcitonin were observed before treatment and 3d,7d,14d and 4w after treatment.Results:After treatment,the scores of neurologic impairment,C-reactive protein and Procalcitonin decreased gradually with the time of treatment(3d-4w),and the scores of neurologic impairment,C-reactive protein and Procalcitonin decreased gradually,there was no difference in the score of nerve function,C-reactive protein and Procalcitonin between the two groups(P>0.05),the score of nerve function,C-reactive protein and Procalcitonin in the Observation Group were lower than those in the Control Group(P<0.05).Conclusion:Jianshen Lishui decoction can improve the neurological function of patients with acute Cerebral Hemorrhage,reduce the expression of C-reactive protein,Procalcitonin.展开更多
Objective:To explore the mechanism of the action of Huoxue Huayu Lishui prescription on acute ankle joint injury.Methods:Forty-eight SPF rats were randomly divided into blank group,model group,Shujin Huoluo capsule gr...Objective:To explore the mechanism of the action of Huoxue Huayu Lishui prescription on acute ankle joint injury.Methods:Forty-eight SPF rats were randomly divided into blank group,model group,Shujin Huoluo capsule group,low,medium and high dose groups for promoting blood circulation and removing blood stasis.The blank group was not modeled,and the other groups were modeled.Each group of 8 animals,the Shujin Huoluo capsule group was given 0.2g/ml mixed liquid by gavage,and the low,medium and high blood circulation and blood stasis Lishui prescription group was given 1.03g/ml,2.06g/ml,4.12g/ml decoction For the stomach,the normal group was given 1.5ml/100g,once a day for 1 week.The expression of NF-κB P65 and transforming growth factor kinase 1(TAK1)protein in the soft tissue around the ankle joint of rats was detected by sports protein immunoblotting method,and the mRNA expression of NF-κB P65 and TAK1 was detected by PCR technology.Results:One day after modeling,the expressions of P65 and TAK1 mRNA and protein in the model group,the positive drug group,and low,medium and high doses of Huoxue Huayu Lishui Recipe were significantly different from those of the blank control group(P<0.05).After taking the medicine for 7 days,compared with the model group,the expressions of P65 and TAK1 mRNA and protein in the Shujin Huoluo capsule group and the low,medium and high dose Huoxue Huayu Lishui Recipe group were all decreased(P<0.05).After 7 days of taking the medicine,compared with the Shujin Huoxue Capsule group,there was no difference in P65 protein in the low-dose Huoxue Huayu Lishui Recipe group.The expression of P65 protein in the middle and high groups and the Shujin Huoxue Capsule group were all decreased(P<0.05).Compared with the Shujin Huoxue Capsule group,the expressions of TAK1 protein,P65 and TAK1 mRNA in the low,medium,and high groups and the Shujin Huoxue Capsule group were all decreased(P<0.05).The results suggest that Huoxue Huayu Lishui Recipe can inhibit the expression of NF-κB P65 and TAK1 protein in ankle joint injury.Conclusion:Huoxue Huayu Lishui prescription may regulate the expression of NF-κB P65 and TAK1 in ankle joint injury of NF-κB rats,so as to improve the clinical symptoms of local swelling and pain in the ankle joint.展开更多
The objective of this study was to investigate the clinical effect of combination treatment of Chinese medicine Baogan Lishui decoction and western medicine on hepatitis B(Hep B)cirrhosis-related refractory ascites.Th...The objective of this study was to investigate the clinical effect of combination treatment of Chinese medicine Baogan Lishui decoction and western medicine on hepatitis B(Hep B)cirrhosis-related refractory ascites.The control group was given conventional western medicine therapy while the observation group was given same conventional western medicine therapy with additional of Chinese medicine Baogan Lishui decoction.The total effective of clinical treatment on Hep B cirrhosis-related refractory ascites in observation group was higher than that of the control group which was 88.89%compared to 71.11%,respectively,and it was significant different(P<0.05).The combination treatment of Chinese medicine Baogan Lishui decoction and conventional western medicine can significantly increase the treatment effect on Hep B cirrhosis refractory ascites,and thus increases the quality and safety of life.展开更多
Objective To study the clinical efficacy of Wenyang Lishui Formula(WYLSF)in preventing ovarian hyperstimulation syndrome(OHSS)and explore the suitable range of estradiol(E_(2))on the human chorionic gonadotropin(HCG)d...Objective To study the clinical efficacy of Wenyang Lishui Formula(WYLSF)in preventing ovarian hyperstimulation syndrome(OHSS)and explore the suitable range of estradiol(E_(2))on the human chorionic gonadotropin(HCG)day in patients with OHSS using WYLSF.Methods Part Ⅰ:eligible patients at high risk for OHSS undergoing ovulation induction between January and December,2023 were randomized into 2 groups based on the actual treatment.The treatment group received 200 mL WYLSF formula twice daily for 5 days after oocyte retrieval in a combination of lifestyle coaching(LC)intervention including regular diet and exercise,whereas the LC group received LC intervention alone.The incidence of OHSS,OHSS self-assessment scales,changes in E_(2) levels on HCG day and 5 days after oocyte retrieval,ovarian morphology changes,and menstrual recovery were compared between the two groups.Part Ⅱ:patients at high risk for OHSS treated with WYLSF were studied.The optimal E_(2) threshold on the HCG day was determined using the maximum selection test,and a multivariate analysis was adopted to compare the relationship between different E_(2) levels on HCG day and hospitalization rate,incidence of moderate to severe OHSS,and self-assessment scales,to explore the preventive effect of WYLSF on OHSS in patients with varying E_(2) levels.Results A total of 120 patients were included in the Part Ⅰ analysis.The treatment group(60 cases)showed a significant reduction in the incidence,duration,and severity of abdominal distension,as well as the incidence of vomiting compared with the LC group(P<0.05).The post-retrieval E_(2) levels in the treatment group decreased significantly more(P=0.032).Among 1,652 patients treated with WYLSF in the Part Ⅱ,90 patients with≤10092 pmol/L,159 with>31074 pmol/L,and 1,403 in the middle range group were formed based on E_(2) levels on HCG day in Part two analysis.Univariate and regression analyses showed that patients with E_(2) levels>31073 pmol/L had a significantly higher incidence of moderate to severe OHSS compared to those with E_(2) levels≤10092 pmol/L(P<0.05).Conclusions WYLSF can effectively reduce specific symptoms in high-risk OHSS patients after ovulation induction and significantly lower E_(2) levels.It may be more suitable for high-risk OHSS patients with E_(2) levels<31073 pmol/L on HCG day.(Registration No.MR-11-23-032493,https://www.medicalresearch.org.cn/login)展开更多
Objective: The objective of this study was to summarize the research context, hotspots, and the development trend of Huoxue lishui method in ophthalmology in the past decade by reviewing the relevant publications. Mat...Objective: The objective of this study was to summarize the research context, hotspots, and the development trend of Huoxue lishui method in ophthalmology in the past decade by reviewing the relevant publications. Materials and Methods: Relevant publications on the application of Huoxue lishui method in ophthalmology from January 1, 2011, to December 31, 2021, in databases such as CNKI, VIP, and Wanfang were retrieved. The analysis of coauthorship, keyword co-occurrence, keyword clustering, keyword emergence, and keyword timeline map of the publications was done with bibliometrics tools CiteSpace and VOSviewer. Results: A total of 100 publications were included in the analysis. The year 2020 saw the publication of most papers concerning the application of Huoxue lishui method in ophthalmology.High-frequency words are macular edema, Huoxue lishui, diabetic macular edema, Huoxue lishui method, Huoxue lishui formula, and promoting Qi and nourishing Yin. Three research hotspots were identified through keyword clustering analysis. Keyword emergence analysis and keyword timeline map indicated that a combined treatment of Huoxue lishui method and promoting Qi and nourishing Yin and diabetic ophthalmology is predicted to be research frontiers. Conclusions: Through the use of knowledge maps, this article reveals the research status in this field in the past decade and highlights the major directions, research hotspots, and development trends, providing references for further research in this field.展开更多
文摘University campus is the most important place for life, study, activity and experience of contemporary college students. It is helpful for students to survive and develop to create the topic space of campus. Taking the topic space of college campuses in Lishui City of Zhejiang Province as an example, the current situations are analyzed through questionnaire survey and field visit. The results show that uni- versity campus space needs a clear topic; the demands are generally large for the topics of exchange and communication, learning and thinking, sports and leisure in all kinds of space; the creation of these types of topic spaces should focus on the peaceful environment, beautiful scenery, privacy of the space and WlFI coverage.
文摘The current development of Lishui tourist transport center is introduced,its forming reason and current problems are analyzed,finally its strengthening strategy is proposed.
文摘A new genus and species of nodosaurid dinosaur： Zhejiangosaurus lishuiensis gen. et sp. nov. is erected herein. It is characterized by the sacrum consisting of at least three true sacral vertebrae, 5 caudal dorsal vertebrae fused to form the presacral rod, wide divergence of long slender preacetabular process of the ilium from the middle line of the body, and the fourth trochanter located at the femoral mid-length.
基金supported by the Fundamental Research Funds for the Central Universities of Ocean University of China(201413005)a China National Science and Technology Major Project(2011ZX05023003)Shanghai Branch,China National Offshore Oil Co.,Ltd.(CNOOC)
文摘The Lishui Sag, in the East China Sea Shelf Basin, is rich in hydrocarbons, with the major hydrocarbon-bearing layers being the Paleocene Mingyuefeng clastic rocks. Analysis of the implicit geologic background information of these Paleocene clastic rocks using petrological and geochemical methods has significant practical importance. These Paleocene sandstones are mainly lithic arenite, lithic arkose and greywacke, composed of K-feldspar, plagioclase, authigenic clays, silica and carbonates. As continental deposits, Yueguifeng clastic rocks have high aluminosilicate and mafic detritus contents, while the Lingfeng and Mingyuefeng Formations are rich in silica due to an oscillating coastal marine depositional environment. The major element contents of these Paleocene sandstones are low and have a concentrated distribution, indicating that the geochemical composition is non-epigenetic, transformed by sedimentary processes and diagenesis. The Yueguifeng detritus comprises recycled sediments, controlled by moderate weathering and erosion, while the Lingfeng and Mingyuefeng detritus is interpreted as primarily first-cycle materials due to low chemical weathering. In the Late Cretaceous to Early Paleocene, the Pacific Plate began subducting under the Eurasian Plate, causing an orogeny by plate collision and magma eruption due to the melting of subducted oceanic crust. This resulted in the dual tectonic settings of ＂active margin＂ and ＂continental island arc＂ in the East China Sea Shelf Basin. During the Late Paleocene, the Pacific Plate margin migrated eastward along with development of the Philippine Ocean Plate, and the tectonic setting of the Lishui Sag gradually turned into a passive continental margin. Detrital sources included both orogenic continental blocks and continental island arcs, and the parent rocks are primarily felsic volcanic rocks and granites.
基金supported by the National Science and Technology Major Projects(No.2016ZX05027-001-006)
文摘The restoration of the denudation thickness is the basis for quantitatively analyzing the basin burial history,thermal evolution history and hydrocarbon accumulation conditions.The well data is not sufficient to do this in the southern Lishui Sag with only 5 wells,so the new,high-quality three-dimensional(3D)seismic data is essential.The methods employed to determine the eroded thicknesses of key unconformities in the study area are the mudstone acoustic time difference(AC)method,vitrinite reflectance(Ro%)method and stratigraphic trend comparison method.On the basis of the structural evolution,the restoration of the paleogeomorphology is carried out.The results show that the Wenzhou formation(E2 w)in the entire study area has been all denuded.The denudation thickness is in the range of 0–550 m,and decreases gradually from west,thicker than 200 m,to east.The erosion of the upper Lingfeng formation(E1l)are mainly occurred in the N-P-1 structural trap(N-P-1),the N-P-2 structural trap(N-P-2)and the N-P-3 structural trap(N-P-3).Among them,the eroded area in N-P-1(near well S-1)and N-P-2 is 200–230 km^2,and the denudation thickness is 0–600 m,which increases from south to north,even up to 200–400 m in the region around well S-1.In N-P-3,the extent of denudation is 30–50 km^2,and the denudation thickness is 0–400 m.In the early stage of the upper E1 l,one north-south strike slip fault began to develop in the southern study area.Affected by this fault,the southern Lingfeng bulge was offset,forming a gorge,and the eastern and western sides of the concave belt connected to each other.On the basis of the paleo-geomorphological characteristics,it is shown that the sedimentary center of the west subsag began to migrate to the south.
基金supported by the National Natural Science Foundation of China (Nos. 51504143 and 51674156)the SDUST Research Fund (No. 2015DJH101)the Major National R&D Projects of China (No. 2016ZX0 5027-001-006)。
文摘In this study, the differences in reservoir parameters, such as pore radius, throat radius, and pore-throat ratio, between the east and west subsags of the Lishui Sag are analyzed by using data obtained from a constant-rate mercury injection experiment. Furthermore, the quality of the reservoirs in the two subsags is systematically evaluated. Results show that the throat radius of the Lishui west subsag is larger than that of the east subsag, and this parameter has a positive correlation with reservoir quality. However, the pore-throat ratio of the east subsag is larger than that of the west subsag, which has an inverse relationship with reservoir quality. The main reasons for this reservoir difference can be attributed to sedimentation and diagenesis. The sedimentary facies types of the Lishui east subsag are the fan delta, shore lake, shallow lake, and shore shallow lake;their sandstone composition maturity is low;the clay mineral content is high;and the rock has undergone strong diagenesis. Therefore, the physical conditions of the reservoir are poor. However, the sandstones in the Lishui west subsag have weak cementation and compaction, mainly with an intergranular pore structure type, which leads to good connectivity between pores. Therefore, the storage performance and seepage capacity of the Lishui west subsag are better than those of the east subsag;the west subsag is the main area of oil and gas accumulation, as confirmed in the process of exploration and development.
基金Supported by Fan's Ophthalmology Project,Affiliated with the Shanghai Municipal Health and Family Planning Commission(No.ZYSNXD-CC-HPGC-FC-002)Scientific and Technological Research Project of Shanghai Municipal Science and Technology Commission(No.17401970700)Shanghai Research Fund for the Doctoral Program(No.B201712)
文摘OBJECTIVE: To investigate a possible mechanism for protective effects of a decoction of the Qinggan Lishui formula(QF) on retinal ganglion cells(RGCs)in a rat model of microbead-induced chronic intraocular hypertension(COH).METHODS: The COH model was generated by injecting microbeads(superparamagnetic iron oxide)into the anterior chamber of rat eyes. QF was given by intragastric administration(gavage) once daily at a dose of 6.2 g/kg until day 28, following microbead injection. Cholera toxin B subunit(CTB) retrograde labeling and immunohistochemistry were used to evaluate changes in the number of RGCs in the retina. Terminal d UTP nick end labeling(TUNEL) staining was used to assess apoptotic changes in RGCs.RESULTS: Microbead injection induced a steady increase in intraocular pressure(IOP) of rats. Elevated IOP resulted in a progressive reduction in the number of CTB-labeled RGCs, 2-4 weeks after microbead injection. QF administration may moderately reduce IOP in the rat COH model and attenuate reduction of the number of CTB-labeled RGCs in COH rats. Furthermore, elevated IOP resulted in a progressive increase in the number of TUNEL-positive RGCs, 2-4 weeks after microbead injection, suggestive of an increase in the extent of RGC apoptosis.There was a significant reduction in the number of TUNEL-positive signals in QF-treated COH retinas,compared with untreated COH retinas.CONCLUSION: QF decoction may provide a protective effect for RGCs in COH retinas by reducing RGC loss; these effects may be mediated by inhibition of RGC apoptosis.
基金the Initial Fund for Young Scholars of Qingdao University of Science and Technology and the National Natural Science Foundation of China(No.51804325)。
文摘Estimation of base level changes in geological records is an important topic for petroleum geologists.Taking the Paleocene Upper Lingfeng Member of Lishui Sag as an example,this paper conducted a base level reconstruction based on Basin Filling Modelling(BFM).The reconstruction was processed on the ground of a previously interpreted seismic stratigraphic framework with several assumptions and simplification.The BFM is implemented with a nonlinear diffusion equation solver written in R coding that excels in shallow marine stratigraphic simulation.The modeled results fit the original stratigraphy very well.The BFM is a powerful tool for reconstructing the base level,and is an effective way to check the reasonableness of previous interpretations.Although simulation solutions may not be unique,the BFM still provides us a chance to gain some insights into the mechanism and dynamic details of the stratigraphy of sedimentary basins.
基金The National Natural Science Foundation of China under contract Nos 42076066 and 92055203。
文摘The East China Sea Shelf Basin generated a series of back-arc basins with thick successions of marine-and terrestrial-facies sediments during Cenozoic.It is enriched with abundant oil and gas resources and is of great significance to the petroleum exploration undertakings.Therein,the Lishui Sag formed fan delta,fluvial delta and littoral-to-neritic facies sediments during Paleocene–Eocene,and the research on its sedimentary environment and sediment source was controversial.This study analyzed the paleontological combination characteristics,and conducted a source-to-sink comparative analysis to restore the sedimentary environment and provenance evolution of the Lishui Sag during Paleocene–Eocene based on the integration of detrital zircon U-Pb age spectra patterns with paleontological assemblages.The results indicated that Lishui Sag was dominated by littoral and neritic-facies environment during time corroborated by large abundance of foraminifera,calcareous nannofossils and dinoflagellates.Chronological analysis of detrital zircon U-Pb revealed that there were significant differences in sediment sources between the east and west area of the Lishui Sag.The western area was featured by deeper water depths in the Paleocene–Eocene,and the sediment was characterized by a single Yanshanian peak of zircon U-Pb age spectra,and mainly influenced from Yanshanian magmatic rocks of South China Coast and the surrounding paleo-uplifts.However,its eastern area partly showed Indosinian populations.In particular,the upper Eocene Wenzhou sediments were featured by increasingly plentiful Precambrian zircons in addition to the large Indosinian-Yanshanian peaks,indicating a possible impact from the Yushan Low Uplift to the east.Therefore,it is likely that the eastern Lishui Sag generated large river systems as well as deltas during time.Due to the Yuquan Movement,the Lishui Sag experienced uplifting and exhumation in the late stage of the late Eocene and was not deposited with sediments until Miocene.Featured by transitional-facies depositions of Paleocene–Eocene,the Lishui Sag thus beared significant potential for source rock and oil-gas reservoir accumulation.
基金Scientific research project of Guangxi administration of traditional Chinese medicine(No.GZZC2020036)Guangxi education department project for scientific research ability promotion of middle-aged and young teachers(No.2020KY07015)。
文摘Objective:To investigate the effect of Jianshen Lishui decoction on C-reactive protein and Procalcitonin in patients with acute Cerebral Hemorrhage.Methods:120 patients with acute spontaneous Cerebral Hemorrhage were randomly divided into two groups:Control Group and the Observation Group.The Control Group was treated with routine Western medicine.The Observation Group was treated with Jianshen Lishui decoction on the basis of the Control Group.The observation period was 4 weeks,the changes of nerve function,C-reactive protein and Procalcitonin were observed before treatment and 3d,7d,14d and 4w after treatment.Results:After treatment,the scores of neurologic impairment,C-reactive protein and Procalcitonin decreased gradually with the time of treatment(3d-4w),and the scores of neurologic impairment,C-reactive protein and Procalcitonin decreased gradually,there was no difference in the score of nerve function,C-reactive protein and Procalcitonin between the two groups(P>0.05),the score of nerve function,C-reactive protein and Procalcitonin in the Observation Group were lower than those in the Control Group(P<0.05).Conclusion:Jianshen Lishui decoction can improve the neurological function of patients with acute Cerebral Hemorrhage,reduce the expression of C-reactive protein,Procalcitonin.
基金Hunan Provincial Traditional Chinese Medicine Scientific Research Program Project(No.201920)National Natural Science Foundation of China(No.81874476)Hunan Natural Science Foundation Project(No.2018JJ2303)。
文摘Objective:To explore the mechanism of the action of Huoxue Huayu Lishui prescription on acute ankle joint injury.Methods:Forty-eight SPF rats were randomly divided into blank group,model group,Shujin Huoluo capsule group,low,medium and high dose groups for promoting blood circulation and removing blood stasis.The blank group was not modeled,and the other groups were modeled.Each group of 8 animals,the Shujin Huoluo capsule group was given 0.2g/ml mixed liquid by gavage,and the low,medium and high blood circulation and blood stasis Lishui prescription group was given 1.03g/ml,2.06g/ml,4.12g/ml decoction For the stomach,the normal group was given 1.5ml/100g,once a day for 1 week.The expression of NF-κB P65 and transforming growth factor kinase 1(TAK1)protein in the soft tissue around the ankle joint of rats was detected by sports protein immunoblotting method,and the mRNA expression of NF-κB P65 and TAK1 was detected by PCR technology.Results:One day after modeling,the expressions of P65 and TAK1 mRNA and protein in the model group,the positive drug group,and low,medium and high doses of Huoxue Huayu Lishui Recipe were significantly different from those of the blank control group(P<0.05).After taking the medicine for 7 days,compared with the model group,the expressions of P65 and TAK1 mRNA and protein in the Shujin Huoluo capsule group and the low,medium and high dose Huoxue Huayu Lishui Recipe group were all decreased(P<0.05).After 7 days of taking the medicine,compared with the Shujin Huoxue Capsule group,there was no difference in P65 protein in the low-dose Huoxue Huayu Lishui Recipe group.The expression of P65 protein in the middle and high groups and the Shujin Huoxue Capsule group were all decreased(P<0.05).Compared with the Shujin Huoxue Capsule group,the expressions of TAK1 protein,P65 and TAK1 mRNA in the low,medium,and high groups and the Shujin Huoxue Capsule group were all decreased(P<0.05).The results suggest that Huoxue Huayu Lishui Recipe can inhibit the expression of NF-κB P65 and TAK1 protein in ankle joint injury.Conclusion:Huoxue Huayu Lishui prescription may regulate the expression of NF-κB P65 and TAK1 in ankle joint injury of NF-κB rats,so as to improve the clinical symptoms of local swelling and pain in the ankle joint.
文摘The objective of this study was to investigate the clinical effect of combination treatment of Chinese medicine Baogan Lishui decoction and western medicine on hepatitis B(Hep B)cirrhosis-related refractory ascites.The control group was given conventional western medicine therapy while the observation group was given same conventional western medicine therapy with additional of Chinese medicine Baogan Lishui decoction.The total effective of clinical treatment on Hep B cirrhosis-related refractory ascites in observation group was higher than that of the control group which was 88.89%compared to 71.11%,respectively,and it was significant different(P<0.05).The combination treatment of Chinese medicine Baogan Lishui decoction and conventional western medicine can significantly increase the treatment effect on Hep B cirrhosis refractory ascites,and thus increases the quality and safety of life.
基金Supported by the National Natural Science Foundation of China(No.82074193)Youth Fund of the National Natural Science Foundation of China(No.82301962)+2 种基金the Special Grant for Capital Health Research and Development(No.2022-2-4097)Key Clinical Projects of Peking University Third Hospital(No.BYSYZD2024008)Capital Medical Research&Development Fund(No.2024-2-4099)。
文摘Objective To study the clinical efficacy of Wenyang Lishui Formula(WYLSF)in preventing ovarian hyperstimulation syndrome(OHSS)and explore the suitable range of estradiol(E_(2))on the human chorionic gonadotropin(HCG)day in patients with OHSS using WYLSF.Methods Part Ⅰ:eligible patients at high risk for OHSS undergoing ovulation induction between January and December,2023 were randomized into 2 groups based on the actual treatment.The treatment group received 200 mL WYLSF formula twice daily for 5 days after oocyte retrieval in a combination of lifestyle coaching(LC)intervention including regular diet and exercise,whereas the LC group received LC intervention alone.The incidence of OHSS,OHSS self-assessment scales,changes in E_(2) levels on HCG day and 5 days after oocyte retrieval,ovarian morphology changes,and menstrual recovery were compared between the two groups.Part Ⅱ:patients at high risk for OHSS treated with WYLSF were studied.The optimal E_(2) threshold on the HCG day was determined using the maximum selection test,and a multivariate analysis was adopted to compare the relationship between different E_(2) levels on HCG day and hospitalization rate,incidence of moderate to severe OHSS,and self-assessment scales,to explore the preventive effect of WYLSF on OHSS in patients with varying E_(2) levels.Results A total of 120 patients were included in the Part Ⅰ analysis.The treatment group(60 cases)showed a significant reduction in the incidence,duration,and severity of abdominal distension,as well as the incidence of vomiting compared with the LC group(P<0.05).The post-retrieval E_(2) levels in the treatment group decreased significantly more(P=0.032).Among 1,652 patients treated with WYLSF in the Part Ⅱ,90 patients with≤10092 pmol/L,159 with>31074 pmol/L,and 1,403 in the middle range group were formed based on E_(2) levels on HCG day in Part two analysis.Univariate and regression analyses showed that patients with E_(2) levels>31073 pmol/L had a significantly higher incidence of moderate to severe OHSS compared to those with E_(2) levels≤10092 pmol/L(P<0.05).Conclusions WYLSF can effectively reduce specific symptoms in high-risk OHSS patients after ovulation induction and significantly lower E_(2) levels.It may be more suitable for high-risk OHSS patients with E_(2) levels<31073 pmol/L on HCG day.(Registration No.MR-11-23-032493,https://www.medicalresearch.org.cn/login)
文摘Objective: The objective of this study was to summarize the research context, hotspots, and the development trend of Huoxue lishui method in ophthalmology in the past decade by reviewing the relevant publications. Materials and Methods: Relevant publications on the application of Huoxue lishui method in ophthalmology from January 1, 2011, to December 31, 2021, in databases such as CNKI, VIP, and Wanfang were retrieved. The analysis of coauthorship, keyword co-occurrence, keyword clustering, keyword emergence, and keyword timeline map of the publications was done with bibliometrics tools CiteSpace and VOSviewer. Results: A total of 100 publications were included in the analysis. The year 2020 saw the publication of most papers concerning the application of Huoxue lishui method in ophthalmology.High-frequency words are macular edema, Huoxue lishui, diabetic macular edema, Huoxue lishui method, Huoxue lishui formula, and promoting Qi and nourishing Yin. Three research hotspots were identified through keyword clustering analysis. Keyword emergence analysis and keyword timeline map indicated that a combined treatment of Huoxue lishui method and promoting Qi and nourishing Yin and diabetic ophthalmology is predicted to be research frontiers. Conclusions: Through the use of knowledge maps, this article reveals the research status in this field in the past decade and highlights the major directions, research hotspots, and development trends, providing references for further research in this field.
