16 ADT carboxylate esters were prepared by means of esterification and these compounds were expected to increase the bioavailability of 4-hydroxyanehole trithione.In vivo studies showed that ADT concentration of 3a in...16 ADT carboxylate esters were prepared by means of esterification and these compounds were expected to increase the bioavailability of 4-hydroxyanehole trithione.In vivo studies showed that ADT concentration of 3a in plasma was much higher than that of ATT during 120 min.Compound 3a could reach blood peak values of ADT at 660.6 ng/mL which was about 14 times of that by ATT.Additionally,the acute toxicity assay indicated high safety of compound 3a that the maximum tolerated dose was no less than 3.25 g/kg.展开更多
[Objectives] To study the material foundation of liposoluble constituents from buds,flowers and fruits of Millettia speciosa Champ.and provide a reference for the development of flowers and fruits of Millettia specios...[Objectives] To study the material foundation of liposoluble constituents from buds,flowers and fruits of Millettia speciosa Champ.and provide a reference for the development of flowers and fruits of Millettia speciosa Champ.[Methods]The liposoluble constituents were extracted from buds,flowers and fruits of Millettia speciosa by Soxhlet extraction and solvent extraction method,and analyzed by GC-MS.[Results]24 compounds were identified from the liposoluble constituents of buds,accounting for 88. 31 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 52. 00%) and alcohols compounds( 17. 46%); 29 compounds were identified from the liposoluble constituents of flowers,accounting for 91. 38 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 60. 64%) and alcohols compounds( 17. 17%); 32 compounds were identified from the liposoluble constituents of fruits,accounting for 80. 01 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 32. 56%),phenyl and its derivatives compounds( 22. 46%) and fatty acids compounds( 12. 54%). 6 compounds were common in buds,flowers and fruits. [Conclusions] Although there were some differences in liposoluble constituents from flowers,fruits,leaves and roots of Millettia speciosa Champ.,the different parts of Millettia speciosa Champ. had development value.展开更多
[Objectives]This paper aimed to analyze the liposoluble components in seeds of different bitter gourd germplasms.[Methods]Taking 3 bitter gourd germplasms from different sources as materials,the composition and relati...[Objectives]This paper aimed to analyze the liposoluble components in seeds of different bitter gourd germplasms.[Methods]Taking 3 bitter gourd germplasms from different sources as materials,the composition and relative contents of liposoluble components in the seeds were analyzed using gas chromatography-mass spectrometry(GC-MS).[Results]A total of 22,18 and 18 compounds were detected from Papua,Y7 and Y108,respectively,accounting for 38.63%,90.20%and 92.53%of the total liposoluble components.Among them,eight liposoluble components were unique to Papua,and two liposoluble components were unique to Y108.The composition and relative contents of liposoluble components differ among different bitter gourd germplasms.The main chemical components wereγ-tocopherol,vitamin E,andβ-tocopherol.The content ofγ-tocopherol was high in the three germplasms,accounting for 8.885%,20.090%and 20.314%,respectively.[Conclusions]This study can lay the foundation for breeding functional bitter gourd varieties.展开更多
[Objectives] To study the liposoluble constituents and their antimicrobial activity from the flowers of Calotropis gigantea.[Methods]The liposoluble constituents from the flowers of Calotropis gigantea were analyzed b...[Objectives] To study the liposoluble constituents and their antimicrobial activity from the flowers of Calotropis gigantea.[Methods]The liposoluble constituents from the flowers of Calotropis gigantea were analyzed by gas chromatography-mass spectrometry(GCMS) method and their relative content was determined by area normalization method; and their antimicrobial activity against 2 pathogens was tested by agar disc diffusion method. [Results]31 compounds were separated and identified,amounting to 85. 14% of the total constituents,27 compounds were reported for the first time in the study of the liposoluble constituents from Calotropis gigantea. The results indicated that the liposoluble constituents from the flowers of Calotropis gigantea exhibited weak antimicrobial activity against Staphylococcus aureus and Canidia albicans. [Conclusions] The research results provided scientific foundation for exploitation and utilization of Calotropis gigantea.展开更多
[Objectives] To effectively develop Calotropis gigantea resources and find the biological active constituents with medicinal value.[Methods]The liposoluble constituents from C. gigantea roots were studied by GC-MS for...[Objectives] To effectively develop Calotropis gigantea resources and find the biological active constituents with medicinal value.[Methods]The liposoluble constituents from C. gigantea roots were studied by GC-MS for the first time. [Results] 62 constituents were separated and identified from C. gigantea roots,amounting to 60. 43% of the total constituents,α-amyrin( 4. 18%),ethyl palmitate( 3. 49%),1,7-dimethyl-naphthalene( 3. 06%) were the main liposoluble constituents. [Conclusions] Cardiac glycoside was mainly found in methanol extracts and not detected in liposoluble constituents by extraction of petroleum ether. However,the present study found another component of low toxicity—naphthalene and its derivatives.展开更多
Clinical studies have associated the consumption of tiger nuts(Cyperus esculentus L.),and its derivates,with improved macular health,due to the presence of certain liposoluble compounds with antioxidant activity,espec...Clinical studies have associated the consumption of tiger nuts(Cyperus esculentus L.),and its derivates,with improved macular health,due to the presence of certain liposoluble compounds with antioxidant activity,especially to lutein and zeaxanthin.However,the benefits derived from ingestion of tiger nut products may vary depending on the release of these compounds from the food matrix to the digestive fluids and their eventual bioabsorption.Therefore,this study aims at evaluating the influence of the food matrix on the liberation and final bioaccessibility of bioactive compounds with positive impact on macular health in different tiger nut products(flour,oil,and milk with and without added sucrose).The in vitro digestibility of macronutrients and the release of vitamin E,lutein,zeaxanthin,β-carotene,and total polyphenols of tiger nut products was studied.In addition,the antioxidant activity of the bioaccessible fraction was determined by ABTS,DPPH and FRAP assays.Results showed that tiger nut milk resulted in the greatest proteolysis and total polyphenols bioaccessibility.Moreover,flour can contribute to hypoglycaemia and,alongside oil,were the best sources of carotenoids and vitamin E.Gastrointestinal digestion increased the antioxidant activity of milk,but the addition of sucrose decreased this effect.The food matrix was a highly relevant factor protecting or hindering the digestion and release of bioactive compounds in the digestive environment.Thus,tiger nut products are presented as ingredients with great potential to develop functional foods oriented to macular health.展开更多
文摘16 ADT carboxylate esters were prepared by means of esterification and these compounds were expected to increase the bioavailability of 4-hydroxyanehole trithione.In vivo studies showed that ADT concentration of 3a in plasma was much higher than that of ATT during 120 min.Compound 3a could reach blood peak values of ADT at 660.6 ng/mL which was about 14 times of that by ATT.Additionally,the acute toxicity assay indicated high safety of compound 3a that the maximum tolerated dose was no less than 3.25 g/kg.
基金Supported by Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences(1630-032017051)Tropical Crop Germplasm Resources Protection Project of the Ministry of Agriculture(16RZZY-101)
文摘[Objectives] To study the material foundation of liposoluble constituents from buds,flowers and fruits of Millettia speciosa Champ.and provide a reference for the development of flowers and fruits of Millettia speciosa Champ.[Methods]The liposoluble constituents were extracted from buds,flowers and fruits of Millettia speciosa by Soxhlet extraction and solvent extraction method,and analyzed by GC-MS.[Results]24 compounds were identified from the liposoluble constituents of buds,accounting for 88. 31 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 52. 00%) and alcohols compounds( 17. 46%); 29 compounds were identified from the liposoluble constituents of flowers,accounting for 91. 38 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 60. 64%) and alcohols compounds( 17. 17%); 32 compounds were identified from the liposoluble constituents of fruits,accounting for 80. 01 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 32. 56%),phenyl and its derivatives compounds( 22. 46%) and fatty acids compounds( 12. 54%). 6 compounds were common in buds,flowers and fruits. [Conclusions] Although there were some differences in liposoluble constituents from flowers,fruits,leaves and roots of Millettia speciosa Champ.,the different parts of Millettia speciosa Champ. had development value.
基金Supported by National Natural Science Foundation of China(31601758)
文摘[Objectives]This paper aimed to analyze the liposoluble components in seeds of different bitter gourd germplasms.[Methods]Taking 3 bitter gourd germplasms from different sources as materials,the composition and relative contents of liposoluble components in the seeds were analyzed using gas chromatography-mass spectrometry(GC-MS).[Results]A total of 22,18 and 18 compounds were detected from Papua,Y7 and Y108,respectively,accounting for 38.63%,90.20%and 92.53%of the total liposoluble components.Among them,eight liposoluble components were unique to Papua,and two liposoluble components were unique to Y108.The composition and relative contents of liposoluble components differ among different bitter gourd germplasms.The main chemical components wereγ-tocopherol,vitamin E,andβ-tocopherol.The content ofγ-tocopherol was high in the three germplasms,accounting for 8.885%,20.090%and 20.314%,respectively.[Conclusions]This study can lay the foundation for breeding functional bitter gourd varieties.
基金Supported by National Natural Science Foundation of Hainan China(20168368)Agro-scientific Research in the Public Interest(201303117)
文摘[Objectives] To study the liposoluble constituents and their antimicrobial activity from the flowers of Calotropis gigantea.[Methods]The liposoluble constituents from the flowers of Calotropis gigantea were analyzed by gas chromatography-mass spectrometry(GCMS) method and their relative content was determined by area normalization method; and their antimicrobial activity against 2 pathogens was tested by agar disc diffusion method. [Results]31 compounds were separated and identified,amounting to 85. 14% of the total constituents,27 compounds were reported for the first time in the study of the liposoluble constituents from Calotropis gigantea. The results indicated that the liposoluble constituents from the flowers of Calotropis gigantea exhibited weak antimicrobial activity against Staphylococcus aureus and Canidia albicans. [Conclusions] The research results provided scientific foundation for exploitation and utilization of Calotropis gigantea.
基金Supported by National Natural Science Foundation of Hainan China(20168368)Species Resources(Tropical Crops)Conservation Project of the Ministry of Agriculture(151721301354052012)
文摘[Objectives] To effectively develop Calotropis gigantea resources and find the biological active constituents with medicinal value.[Methods]The liposoluble constituents from C. gigantea roots were studied by GC-MS for the first time. [Results] 62 constituents were separated and identified from C. gigantea roots,amounting to 60. 43% of the total constituents,α-amyrin( 4. 18%),ethyl palmitate( 3. 49%),1,7-dimethyl-naphthalene( 3. 06%) were the main liposoluble constituents. [Conclusions] Cardiac glycoside was mainly found in methanol extracts and not detected in liposoluble constituents by extraction of petroleum ether. However,the present study found another component of low toxicity—naphthalene and its derivatives.
基金support from the Universitat Politecnica de Valencia(UPV)and Fundacio per al Foment de la Investigacio Sanitaria i Biomedica de la Comunitat Valenciana(FISABIO)through the Project FOOD4VISION under Grant POLISABIO 2019,A04.Funding for open access charge:CRUE-Universitat Politecnica de Valencia.
文摘Clinical studies have associated the consumption of tiger nuts(Cyperus esculentus L.),and its derivates,with improved macular health,due to the presence of certain liposoluble compounds with antioxidant activity,especially to lutein and zeaxanthin.However,the benefits derived from ingestion of tiger nut products may vary depending on the release of these compounds from the food matrix to the digestive fluids and their eventual bioabsorption.Therefore,this study aims at evaluating the influence of the food matrix on the liberation and final bioaccessibility of bioactive compounds with positive impact on macular health in different tiger nut products(flour,oil,and milk with and without added sucrose).The in vitro digestibility of macronutrients and the release of vitamin E,lutein,zeaxanthin,β-carotene,and total polyphenols of tiger nut products was studied.In addition,the antioxidant activity of the bioaccessible fraction was determined by ABTS,DPPH and FRAP assays.Results showed that tiger nut milk resulted in the greatest proteolysis and total polyphenols bioaccessibility.Moreover,flour can contribute to hypoglycaemia and,alongside oil,were the best sources of carotenoids and vitamin E.Gastrointestinal digestion increased the antioxidant activity of milk,but the addition of sucrose decreased this effect.The food matrix was a highly relevant factor protecting or hindering the digestion and release of bioactive compounds in the digestive environment.Thus,tiger nut products are presented as ingredients with great potential to develop functional foods oriented to macular health.
