针对Wav2Lip模型计算量大,推理速度慢,在一些对实时性要求较高或算力较为有限的应用场景中可能难以满足预期效果等问题,论文提出了基于全局通道数剪枝的方法,选用了三种不同剪枝比例,对Wav2Lip模型进行了全局通道数剪枝并对比。实验结...针对Wav2Lip模型计算量大,推理速度慢,在一些对实时性要求较高或算力较为有限的应用场景中可能难以满足预期效果等问题,论文提出了基于全局通道数剪枝的方法,选用了三种不同剪枝比例,对Wav2Lip模型进行了全局通道数剪枝并对比。实验结果表明,论文提出的全局通道数剪枝方案成功地:1) 提升了推理速度;2) 减小了模型体积;3) 保持或提升了所生成图像的效果。该方案在降低计算成本的同时,能够实现高效且稳定的推理性能。In response to the issues of high computational complexity, slow inference speed, and potential difficulty in achieving expected results in some application scenarios that require high real-time performance or limited computing power for the Wav2Lip model, the paper proposes a method based on global channel pruning, using three different pruning ratios to perform global channel pruning on the Wav2Lip model and compare them, the experimental results show that the global channel pruning scheme proposed in the paper successfully: 1) improves inference speed;2) Reduced the size of the model;3) Maintained or improved the effect of the generated image. This solution can achieve efficient and stable inference performance while reducing computational costs.展开更多
This study used non-invasive evaluation methods measured six skin physiological parameters of the lower lip in 180 subjects,including moisture content,transepidermal water loss(TEWL),smoothness(SESM),scaliness of the ...This study used non-invasive evaluation methods measured six skin physiological parameters of the lower lip in 180 subjects,including moisture content,transepidermal water loss(TEWL),smoothness(SESM),scaliness of the skin(SESC),wrinkles(SEW),and red area of the lip skin,and compared the effects of 6 groups of lip balms(no-additive group,marine oligosaccharides group,ceramides group,glycyrrhizinic acid group,allantoin group,and mixed group;30 each)on the skin physiological parameters of dry,flaking,and cracked lip subjects.The results showed that the lip mositure content of the subjects in the marine oligosaccharide group,glycyrrhetinic acid group,and allantoin group increased significantly by 44.40%,42.84%and 58.08%after 7 days of lip balm(P<0.05).The TEWL in the ceramide group and the allantoin group was significantly reduced by 21.83%and 24.72%,respectively,after 7 days of lip paste use(P<0.05).The lip skin smoothness values of subjects in the glycyrrhizic acid group and the allantoin group were significantly reduced by 18.76%and 14.97%,respectively,after 28 days of lip balm application(P<0.05).The lip skin scaling indices of subjects in the marine oligosaccharide group,the ceramides group,and the allantoin group were significantly reduced by 33.77%,42.69%,and 38.07%,respectively,after 28 days of lip balm application(P<0.05).The wrinkle parameters of the lip skin of the subjects in the marine oligosaccharide,glycyrrhizinic acid and allantoin groups were significantly reduced by 23.06%,23.29%and 25.98%,respectively,after 28 days of lip balm application(P<0.05).And the area of the red zone of the lip skin of the subjects in the allantoin group was significantly reduced by 4.27%,after 28 days of lip balm application(P<0.05).Combining the effects of the four active ingredients on the secretion of hyaluronic acid(moisturizing effect)and inflammatory factor(IL-6)in HSF cells,it suggests that marine oligosaccharides and allantoin have a perfect impact on enhancing the water content of the skin on the lips of the subjects,and further improve the symptoms of flaking and wrinkles on the lips of the subjects.The ceramide and allantoin can repair the skin barrier well and have a good effect on the chapped and flaky lips of the subjects.After 28 days of using lip balm,the water content of lips in the mixed group increased,the skin barrier was repaired and became smoother,and the wrinkles,scale index,and red zone value were reduced,which could well relieve chronic lip inflammation and lay a foundation for developing lip products for the treatment of chronic cheilitis.展开更多
Background: In developing countries, charity cleft surgical mission is always operated by sporadic surgical teams without systematic follow up and quality assurance. In the past few decades, many mission projects have...Background: In developing countries, charity cleft surgical mission is always operated by sporadic surgical teams without systematic follow up and quality assurance. In the past few decades, many mission projects have been held regularly in China. The purpose of this audit was a retrospective analysis of a 9-year cleft lip and palate charity project operated in a tertiary hospital in China Shenzhen Area to evaluate perioperative and postoperative complications. Nevertheless, understanding the risk profile is essential for establishing a sustainable in-house cleft service in Shenzhen. Methods: A detailed analysis of hospital centralized record in the The University of Hong Kong-Shenzhen Hospital (HKUSZH) was reviewed since the first charity project held in 2015. The parameters of this audit were focused on perioperative complications including anesthesia related problems, early postoperative complications in patients who underwent primary or secondary cleft surgeries. A total of 430 consecutive admitted cases of 311 non-syndromic cleft lip & palate patients were enrolled into the charity project from June 2015 to July 2024. The main anesthesia related complications that occurred during general anesthesia were respiratory tract problems, while intraoperative complication was excessive bleeding, so as wound local infection and reaction were the main early postoperative complications. Results: In our 9-year clinical audit of 430 cleft lip and palate charity surgeries in Shenzhen, we observed no mortalities and a anesthesia-related complication rate of 1.16%. Specific intraoperative complications included excessive bleeding, while early postoperative issues were dominated by wound infections. The fistula rate of 18.7% post palate repair and the average hospital stay of 3.71 days complete the profile of our surgical outcomes. These data underscore the project’s efficacy and offer a reference for international cleft missions aiming for safe and efficient surgical care. Conclusions: This study provides a thorough data review of the complications in the past 9 years charity missions for cleft lip and palate surgery in a well-structured hospital infrastructure and logistic support by local surgical team. There were no perioperative or postoperative death during the study period and the overall short-term complication rate was low. Therefore, it could be a reference model for other international cleft mission in developing country for a safe and efficient service in future.展开更多
Background Lip reading uses lip images for visual speech recognition.Deep-learning-based lip reading has greatly improved performance in current datasets;however,most existing research ignores the significance of shor...Background Lip reading uses lip images for visual speech recognition.Deep-learning-based lip reading has greatly improved performance in current datasets;however,most existing research ignores the significance of short-term temporal dependencies of lip-shape variations between adjacent frames,which leaves space for further improvement in feature extraction.Methods This article presents a spatiotemporal feature fusion network(STDNet)that compensates for the deficiencies of current lip-reading approaches in short-term temporal dependency modeling.Specifically,to distinguish more similar and intricate content,STDNet adds a temporal feature extraction branch based on a 3D-CNN,which enhances the learning of dynamic lip movements in adjacent frames while not affecting spatial feature extraction.In particular,we designed a local–temporal block,which aggregates interframe differences,strengthening the relationship between various local lip regions through multiscale convolution.We incorporated the squeeze-and-excitation mechanism into the Global-Temporal Block,which processes a single frame as an independent unitto learn temporal variations across the entire lip region more effectively.Furthermore,attention pooling was introduced to highlight meaningful frames containing key semantic information for the target word.Results Experimental results demonstrated STDNet's superior performance on the LRW and LRW-1000,achieving word-level recognition accuracies of 90.2% and 53.56%,respectively.Extensive ablation experiments verified the rationality and effectiveness of its modules.Conclusions The proposed model effectively addresses short-term temporal dependency limitations in lip reading,and improves the temporal robustness of the model against variable-length sequences.These advancements validate the importance of explicit short-term dynamics modeling for practical lip-reading systems.展开更多
Microwave thermochemotherapy(MTC)has been applied to treat lip squamous cell carcinoma(LSCC),but a deeper understanding of its therapeutic mechanisms and molecular biology is needed.To address this,we used single-cell...Microwave thermochemotherapy(MTC)has been applied to treat lip squamous cell carcinoma(LSCC),but a deeper understanding of its therapeutic mechanisms and molecular biology is needed.To address this,we used single-cell transcriptomics(scRNA-seq)and spatial transcriptomics(ST)to highlight the pivotal role of tumor-associated neutrophils(TANs)among tumor-infiltrating immune cells and their therapeutic response to MTC.MNDA+TANs with anti-tumor activity(N1-phenotype)are found to be abundantly infiltrated by MTC with benefit of increased blood perfusion,and these TANs are characterized by enhanced cytotoxicity,ameliorated hypoxia,and upregulated IL1B,activating T&NK cells and fibroblasts via IL1B-IL1R.In this highly anti-tumor immunogenic and hypoxia-reversed microenvironment under MTC,fibroblasts accumulated in the tumor front(TF)can recruit N1-TANs via CXCL2-CXCR2 and clear N2-TANs(pro-tumor phenotype)via CXCL12-CXCR4,which results in the aggregation of N1-TANs and extracellular matrix(ECM)deposition.In addition,we construct an N1-TANs marker,MX2,which positively correlates with better prognosis in LSCC patients,and employ deep learning techniques to predict expression of MX2 from hematoxylin-eosin(H&E)-stained images so as to conveniently guide decision making in clinical practice.Collectively,our findings demonstrate that the N1-TANs/fibroblasts defense wall formed in response to MTC effectively combat LSCC.展开更多
文摘针对Wav2Lip模型计算量大,推理速度慢,在一些对实时性要求较高或算力较为有限的应用场景中可能难以满足预期效果等问题,论文提出了基于全局通道数剪枝的方法,选用了三种不同剪枝比例,对Wav2Lip模型进行了全局通道数剪枝并对比。实验结果表明,论文提出的全局通道数剪枝方案成功地:1) 提升了推理速度;2) 减小了模型体积;3) 保持或提升了所生成图像的效果。该方案在降低计算成本的同时,能够实现高效且稳定的推理性能。In response to the issues of high computational complexity, slow inference speed, and potential difficulty in achieving expected results in some application scenarios that require high real-time performance or limited computing power for the Wav2Lip model, the paper proposes a method based on global channel pruning, using three different pruning ratios to perform global channel pruning on the Wav2Lip model and compare them, the experimental results show that the global channel pruning scheme proposed in the paper successfully: 1) improves inference speed;2) Reduced the size of the model;3) Maintained or improved the effect of the generated image. This solution can achieve efficient and stable inference performance while reducing computational costs.
文摘This study used non-invasive evaluation methods measured six skin physiological parameters of the lower lip in 180 subjects,including moisture content,transepidermal water loss(TEWL),smoothness(SESM),scaliness of the skin(SESC),wrinkles(SEW),and red area of the lip skin,and compared the effects of 6 groups of lip balms(no-additive group,marine oligosaccharides group,ceramides group,glycyrrhizinic acid group,allantoin group,and mixed group;30 each)on the skin physiological parameters of dry,flaking,and cracked lip subjects.The results showed that the lip mositure content of the subjects in the marine oligosaccharide group,glycyrrhetinic acid group,and allantoin group increased significantly by 44.40%,42.84%and 58.08%after 7 days of lip balm(P<0.05).The TEWL in the ceramide group and the allantoin group was significantly reduced by 21.83%and 24.72%,respectively,after 7 days of lip paste use(P<0.05).The lip skin smoothness values of subjects in the glycyrrhizic acid group and the allantoin group were significantly reduced by 18.76%and 14.97%,respectively,after 28 days of lip balm application(P<0.05).The lip skin scaling indices of subjects in the marine oligosaccharide group,the ceramides group,and the allantoin group were significantly reduced by 33.77%,42.69%,and 38.07%,respectively,after 28 days of lip balm application(P<0.05).The wrinkle parameters of the lip skin of the subjects in the marine oligosaccharide,glycyrrhizinic acid and allantoin groups were significantly reduced by 23.06%,23.29%and 25.98%,respectively,after 28 days of lip balm application(P<0.05).And the area of the red zone of the lip skin of the subjects in the allantoin group was significantly reduced by 4.27%,after 28 days of lip balm application(P<0.05).Combining the effects of the four active ingredients on the secretion of hyaluronic acid(moisturizing effect)and inflammatory factor(IL-6)in HSF cells,it suggests that marine oligosaccharides and allantoin have a perfect impact on enhancing the water content of the skin on the lips of the subjects,and further improve the symptoms of flaking and wrinkles on the lips of the subjects.The ceramide and allantoin can repair the skin barrier well and have a good effect on the chapped and flaky lips of the subjects.After 28 days of using lip balm,the water content of lips in the mixed group increased,the skin barrier was repaired and became smoother,and the wrinkles,scale index,and red zone value were reduced,which could well relieve chronic lip inflammation and lay a foundation for developing lip products for the treatment of chronic cheilitis.
文摘Background: In developing countries, charity cleft surgical mission is always operated by sporadic surgical teams without systematic follow up and quality assurance. In the past few decades, many mission projects have been held regularly in China. The purpose of this audit was a retrospective analysis of a 9-year cleft lip and palate charity project operated in a tertiary hospital in China Shenzhen Area to evaluate perioperative and postoperative complications. Nevertheless, understanding the risk profile is essential for establishing a sustainable in-house cleft service in Shenzhen. Methods: A detailed analysis of hospital centralized record in the The University of Hong Kong-Shenzhen Hospital (HKUSZH) was reviewed since the first charity project held in 2015. The parameters of this audit were focused on perioperative complications including anesthesia related problems, early postoperative complications in patients who underwent primary or secondary cleft surgeries. A total of 430 consecutive admitted cases of 311 non-syndromic cleft lip & palate patients were enrolled into the charity project from June 2015 to July 2024. The main anesthesia related complications that occurred during general anesthesia were respiratory tract problems, while intraoperative complication was excessive bleeding, so as wound local infection and reaction were the main early postoperative complications. Results: In our 9-year clinical audit of 430 cleft lip and palate charity surgeries in Shenzhen, we observed no mortalities and a anesthesia-related complication rate of 1.16%. Specific intraoperative complications included excessive bleeding, while early postoperative issues were dominated by wound infections. The fistula rate of 18.7% post palate repair and the average hospital stay of 3.71 days complete the profile of our surgical outcomes. These data underscore the project’s efficacy and offer a reference for international cleft missions aiming for safe and efficient surgical care. Conclusions: This study provides a thorough data review of the complications in the past 9 years charity missions for cleft lip and palate surgery in a well-structured hospital infrastructure and logistic support by local surgical team. There were no perioperative or postoperative death during the study period and the overall short-term complication rate was low. Therefore, it could be a reference model for other international cleft mission in developing country for a safe and efficient service in future.
基金Supported by the National Key Research and Development Program of China(2023YFC3306201)the National Natural Science Foundation of China(61772125)the Fundamental Research Funds for the Central Universities(N2317004).
文摘Background Lip reading uses lip images for visual speech recognition.Deep-learning-based lip reading has greatly improved performance in current datasets;however,most existing research ignores the significance of short-term temporal dependencies of lip-shape variations between adjacent frames,which leaves space for further improvement in feature extraction.Methods This article presents a spatiotemporal feature fusion network(STDNet)that compensates for the deficiencies of current lip-reading approaches in short-term temporal dependency modeling.Specifically,to distinguish more similar and intricate content,STDNet adds a temporal feature extraction branch based on a 3D-CNN,which enhances the learning of dynamic lip movements in adjacent frames while not affecting spatial feature extraction.In particular,we designed a local–temporal block,which aggregates interframe differences,strengthening the relationship between various local lip regions through multiscale convolution.We incorporated the squeeze-and-excitation mechanism into the Global-Temporal Block,which processes a single frame as an independent unitto learn temporal variations across the entire lip region more effectively.Furthermore,attention pooling was introduced to highlight meaningful frames containing key semantic information for the target word.Results Experimental results demonstrated STDNet's superior performance on the LRW and LRW-1000,achieving word-level recognition accuracies of 90.2% and 53.56%,respectively.Extensive ablation experiments verified the rationality and effectiveness of its modules.Conclusions The proposed model effectively addresses short-term temporal dependency limitations in lip reading,and improves the temporal robustness of the model against variable-length sequences.These advancements validate the importance of explicit short-term dynamics modeling for practical lip-reading systems.
基金supported by National Natural Science Foundation of China grants(Nos.82173326 and 82473058)Key Research and Development Project of Sichuan Province(Nos.2024YFFK0374 and 2024YFFK0198)Interdisciplinary Innovation Project of West China College of Stomatology,Sichuan University(RD-03-202004).
文摘Microwave thermochemotherapy(MTC)has been applied to treat lip squamous cell carcinoma(LSCC),but a deeper understanding of its therapeutic mechanisms and molecular biology is needed.To address this,we used single-cell transcriptomics(scRNA-seq)and spatial transcriptomics(ST)to highlight the pivotal role of tumor-associated neutrophils(TANs)among tumor-infiltrating immune cells and their therapeutic response to MTC.MNDA+TANs with anti-tumor activity(N1-phenotype)are found to be abundantly infiltrated by MTC with benefit of increased blood perfusion,and these TANs are characterized by enhanced cytotoxicity,ameliorated hypoxia,and upregulated IL1B,activating T&NK cells and fibroblasts via IL1B-IL1R.In this highly anti-tumor immunogenic and hypoxia-reversed microenvironment under MTC,fibroblasts accumulated in the tumor front(TF)can recruit N1-TANs via CXCL2-CXCR2 and clear N2-TANs(pro-tumor phenotype)via CXCL12-CXCR4,which results in the aggregation of N1-TANs and extracellular matrix(ECM)deposition.In addition,we construct an N1-TANs marker,MX2,which positively correlates with better prognosis in LSCC patients,and employ deep learning techniques to predict expression of MX2 from hematoxylin-eosin(H&E)-stained images so as to conveniently guide decision making in clinical practice.Collectively,our findings demonstrate that the N1-TANs/fibroblasts defense wall formed in response to MTC effectively combat LSCC.
