Studies have indicated that night lights interfere with the circadian rhythm in the human body and threaten human health. Our previous studies indicated that continuous light exposure severely damages the reproductive...Studies have indicated that night lights interfere with the circadian rhythm in the human body and threaten human health. Our previous studies indicated that continuous light exposure severely damages the reproductive endocrine system of female rats resembles polycystic ovary syndrome in women. In this study, we used the continuous measurement method to observe changes in the basal physiological indicators of female rats in an abnormal light exposure environment. Our study results indicated that in female rats: 1) the body temperature first continuously and gradually increased followed by a gradually decrease;2) the increase in body weight slowed down at the late stage of the experimental process;3) the random blood glucose level increased, and the fasting serum insulin level decreased;and 4) the serum C-reactive protein level increased. Our study investigated for the first time the correlation between the duration of continuous light exposure in female rats and the continuously measured basal physiological indicators and preliminarily discussed the effect of continuous light exposure on female basal metabolism and the possible inflammation mechanism. We propose that long-term continuous exposure to night lights in females severely damages their immune and metabolic systems.展开更多
During autologous bone marrow graft in treatment of malignant diseases, it is critical to purge malignant cells from the marrow. In the present study, the sensitivity to photodynamic inactivation of 3 leukemic cell li...During autologous bone marrow graft in treatment of malignant diseases, it is critical to purge malignant cells from the marrow. In the present study, the sensitivity to photodynamic inactivation of 3 leukemic cell lines was compared with their counterpart normal hematopoietic cells. After mouse leukemic L1210 cells were treated with a preparation of hematoporphyrin derivatives, YHpD, 10 μg/ml for 1 hr. and irradiated with blacklight (peak wavelength 395 nm, light intensity 0.6 mW/cm2) for 5 minutes, the survival rate of clonogenic cells decreased to <10%, while that of bone marrow granulocyte macrophage progenitor cells (CFU-GM) in DBA/2 mice remained at nearly normal level (>80%). Similar results were obtained when human leukemic HL-60 cells were compared with human CFU-GM and mouse leukemic L615 cells with CFU-GM in 615 strain mice. It is suggested that hematoporphyrin photoradiation may be useful for Iselectively killing leukemic cells in bone marrow.展开更多
Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss.Ferroptosis has been demonstrated to be associated with retinal deg...Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss.Ferroptosis has been demonstrated to be associated with retinal degenerative diseases.However,the molecular mechanisms underlying ferroptosis and photoreceptor cell death in age-related macular degeneration remain largely unexplored.Bioinformatics and biochemical analyses in this study revealed xC^(–),solute carrier family 7 member 11-regulated ferroptosis as the predominant pathological process of photoreceptor cell degeneration in a light-induced dry age-related macular degeneration mouse model.This process involves the nuclear factor-erythroid factor 2-related factor 2-solute carrier family 7 member 11-glutathione peroxidase 4 signaling pathway,through which cystine depletion,iron ion accumulation,and enhanced lipid peroxidation ultimately lead to photoreceptor cell death and subsequent visual function impairment.We demonstrated that solute carrier family 7 member 11 overexpression blocked this process by inhibiting oxidative stress in vitro and in vivo.Conversely,solute carrier family 7 member 11 knockdown or the solute carrier family 7 member 11 inhibitor sulfasalazine and ferroptosis-inducing agent erastin aggravated H_(2)O_(2)-induced ferroptosis of 661W cells.These findings indicate solute carrier family 7 member 11 may be a potential therapeutic target for patients with retinal degenerative diseases including age-related macular degeneration.展开更多
In museum design and operation,daylight is typically discouraged due to high risk of damaging the display objects.However,past studies in high-latitude regions have shown the possibility to apply daylight in museums,s...In museum design and operation,daylight is typically discouraged due to high risk of damaging the display objects.However,past studies in high-latitude regions have shown the possibility to apply daylight in museums,so long as it is carefully planned,and the display objects are not from the category of high responsive materials.In the tropical region,the influence of daylighting on light exposure on museum objects is still unknown.This study therefore aims to assess and mitigate the impact of annual daylight exposure on objects with low responsive materials in a tropical daylit museum building.Annual daylight modelling and simulation are performed to achieve the objective,followed with Morris sensitivity analysis and Mahalanobis distance classifier to optimise the outcome.It is found that either WWR or glazing transmissivity gives the greatest influence on the performance indicators.Based on the proposed optimisation algorithm,it is possible to determine the optimum solutions satisfying the performance indicators target,for a certain opening type.Overall,the contribution of this study is the proposed computational modelling and simulation methods to mitigate the exposure risk while optimising daylight as a renewable energy source.展开更多
The purpose of this study is to examine how daylight exposure affects the health and well-being of office workers.Sleep actigraphy and health and well-being related survey data were the main dependent variables in thi...The purpose of this study is to examine how daylight exposure affects the health and well-being of office workers.Sleep actigraphy and health and well-being related survey data were the main dependent variables in this study.Research samples were composed of participants from the United States and South Korea,each set of workers divided into those having daylight at their workplaces and those without.Fifty participants in total wore for two weeks actiwatches equipped with light sensors to measure sleep quality and exposure to ambient light levels.Additional health and well-being measurements were taken using well established survey instruments such as the SF-36 for general and mental health,and the Pittsburg Sleep Quality Index(PSQI)for sleep.In order to estimate the levels of daylight participants were exposed to,computer simulation was used to generate the total annual daylight levels in each participant’s office.Our results seem to indicate that working in daylit office spaces would lead to higher sleep quality and higher scores of the health and well-being scales compared to those who do not work under daylight conditions.Our findings indicate that it is important to provide and maintain significant daylight levels at the workplace.Consequently,in terms of architectural design,building orientation,building dimensions,and the size and height of windows should be taken into consideration to optimize or maximize daylight exposure.展开更多
Red-fleshed fruits are valued for their vibrant color and high anthocyanin content.Pre-harvest fruit bagging enhances fruit peel pigmentation,but its effect on flesh coloration remains poorly characterized.This study ...Red-fleshed fruits are valued for their vibrant color and high anthocyanin content.Pre-harvest fruit bagging enhances fruit peel pigmentation,but its effect on flesh coloration remains poorly characterized.This study revealed that removing bags from‘Gengcunyangtao’red-fleshed peach fruits triggers the rapid and uniform accumulation of anthocyanins in the flesh,resulting in anthocyanin levels that exceed those in unbagged fruits.The exposure to light after bag removal triggered significant increases in anthocyanin levels within 24 h.This was accompanied by the rapid upregulation of light-responsive and flavonoid biosynthetic gene expression levels within 6 h.A metabolomic analysis indicated that anthocyanin precursors,especially p-coumaric acid,accumulated before bag removal,thereby increasing substrate availability for rapid anthocyanin synthesis.On the basis of a weighted gene co-expression network analysis,MYB transcription factors,anthocyanin transporters,glutathione S-transferase,and multidrug and toxic compound extrusion(MATE)were identified as key regulators that coordinate precursor storage along with light-induced transcriptional activation.Notably,PpMYB4 binds to the promoter of PpGSTF14 and activates its expression,thereby promoting anthocyanin accumulation.The study findings elucidated the temporal coordination of metabolic priming and light-responsive transcriptional regulation driving rapid anthocyanin biosynthesis,with possible implications for improving peach fruit flesh coloration.展开更多
The purpose of this article is to summarize the methods most commonly used to measure time spent outdoors and provide a comprehensive review of time and activity recording methods with the aim of encouraging the devel...The purpose of this article is to summarize the methods most commonly used to measure time spent outdoors and provide a comprehensive review of time and activity recording methods with the aim of encouraging the development of new methods. PubMed, Embase and the Cochrane Library were searched from Jan. 1st, 1990 to Aug. 31th, 2017. Studies including the following specific terms： “outdoor”, “outside”, “outdoor activity”, “outside activity”, “outdoor time”, “outside time”, and “outdoor AND measurement of time spent outdoors” were considered for this review. In total, three kinds of outdoor time measurements were discussed. Questionnaires have the longest history and are the most thoroughly revised instruments for assessing time spent outdoors, but recall bias is their most substantial drawback. Global positioning system （GPS） tracking can distinguish between indoor and outdoor locations, but its utility is limited due to several factors such as subject compatibility. Light exposure measurement devices are newly emerging, but all of these devices require good subject cooperation. Further efforts and exploration are needed to develop better methods and new tools to record exposure to the outdoors in real time. Moreover, inventing a new device by combining two or more types of devices mentioned above and using the latest technology of en ergy supplementation and autoswitching may make the best use of the advantages and bypass the disadvantages of each tool.展开更多
The earliest stages of plant succession on severely disturbed sites usually follow highly unpredictable trajectories. However, in the Popocatépetl volcano area(50 km SE of Mexico City),the development of physiogn...The earliest stages of plant succession on severely disturbed sites usually follow highly unpredictable trajectories. However, in the Popocatépetl volcano area(50 km SE of Mexico City),the development of physiognomically distinct primary plant communities suggests the occurrence of various successional trajectories only 10 years after the onset of colonization of a temperate forest on lahars. To characterize plant communities and determine the environmental factors that drive the differences observed between plant communities and their successional trajectories, we monitored 64 circular sample plots(3.14 m2) from 2002 to 2011. We examined the plant communities' composition and structure in terms of their species richness and abundance, plant cover, and maximum stem height,and recorded 13 environmental factors related to the volcanic deposit characteristics, microclimate, soil,flow dynamics and gravitational processes. A cluster analysis of the species abundance data showed that,by 2011, six plant community types(CT's) had established, including grasslands, and open, dense and very dense shrub lands. As these communities developed over the same period of time and within the same overall ecosystem, then these plant community types were interpreted as different stages of the same successional trajectory. Two sequential main stages that drive regeneration were identified from this successional trajectory: a) the first four years are characterized by a steady increase in species richness and physiognomic development(plant size and coverage), mostly dominated by Baccharis conferta, Eupatorium glabratum and Senecio barbajohannis; b) from the sixth year onwards, a continued increase in the abundance of those same species led to the development of the dense shrubland communities.Differences in the availability of soil resources and disturbances linked to recent lahar flows were the main factors accounting for such differences.展开更多
Lateralization of cognitive functions influences a large number of fitness-related behaviors and shows,in most species,substantial variation in strength and direction.Laboratory works and field data have suggested tha...Lateralization of cognitive functions influences a large number of fitness-related behaviors and shows,in most species,substantial variation in strength and direction.Laboratory works and field data have suggested that this variation is often due to adaptive phenotypic plasticity.Strong lateralization should be favored in some ecological conditions,for example,under high risk of predation.For anuran tadpoles,the presence of cover affects predation risk,with tadpoles being more exposed to predators in environments with reduced cover.We tested the hypothesis that the amount of cover experienced early in life affects lateralization in the edible frog,Pelophylax escu-lentus,tadpoles.We exposed embryos and larvae to high or low vegetation cover environments.For half of the subjects,the treatment was constant whereas the remaining subjects were switched to the opposite treatment after hatching.In agreement with the theoretical expectation,tadpoles exposed to low vegetation cover for the entire development were more lateralized and showed a stronger alignment in directionality of lateralization compared with tadpoles exposed to high vege-tation cover.This indicates a possible role of natural variation in vegetation abundance and deve卜opmental plasticity as determinants of between-population and between-individual differences in lateralization.We also found that shifting from high to low vegetation cover treatments and vice versa disrupted lateralization alignment,suggesting that developmental trajectories for this trait are determined at the embryonic stage and need environmental stability to be fully expressed.展开更多
Light is an important external factor that affects human circadian rhythms.This study aimed to explore the effects of different dimensions of diurnal light exposure on the physiological circadian phase shift(CPS)of th...Light is an important external factor that affects human circadian rhythms.This study aimed to explore the effects of different dimensions of diurnal light exposure on the physiological circadian phase shift(CPS)of the human body.A strict light exposure experiment with different timing schemes(8:00-12:00,13:00-17:00,18:00-22:00),durations(4 h,8 h)and effective circadian stimulus levels(circadian stimulus:0.35,0.55)was performed in an enclosed laboratory.Fourteen participants,including seven males and seven females,with a mean age of 24.29±2.43(mean±standard deviation),participated in this experiment and experienced all six lighting schemes.The results showed that both time factor(F_(3,40)=29.079,p<0.001,the power of the sample size=0.98)and circadian stimulus levels(T_(20)=−2.415,p=0.025,the power of sample size=0.76)sig-nificantly affect the CPS.On this basis,a diurnal circadian lighting accumulation(DCLA)-CPS model was proposed in the form of the Boltzmann function,and was validated by experimental data with high correlation(R^(2)=0.9320,RSS=0.1184),which provides strong support for rationally arranging the light level at different times of the day.展开更多
文摘Studies have indicated that night lights interfere with the circadian rhythm in the human body and threaten human health. Our previous studies indicated that continuous light exposure severely damages the reproductive endocrine system of female rats resembles polycystic ovary syndrome in women. In this study, we used the continuous measurement method to observe changes in the basal physiological indicators of female rats in an abnormal light exposure environment. Our study results indicated that in female rats: 1) the body temperature first continuously and gradually increased followed by a gradually decrease;2) the increase in body weight slowed down at the late stage of the experimental process;3) the random blood glucose level increased, and the fasting serum insulin level decreased;and 4) the serum C-reactive protein level increased. Our study investigated for the first time the correlation between the duration of continuous light exposure in female rats and the continuously measured basal physiological indicators and preliminarily discussed the effect of continuous light exposure on female basal metabolism and the possible inflammation mechanism. We propose that long-term continuous exposure to night lights in females severely damages their immune and metabolic systems.
文摘During autologous bone marrow graft in treatment of malignant diseases, it is critical to purge malignant cells from the marrow. In the present study, the sensitivity to photodynamic inactivation of 3 leukemic cell lines was compared with their counterpart normal hematopoietic cells. After mouse leukemic L1210 cells were treated with a preparation of hematoporphyrin derivatives, YHpD, 10 μg/ml for 1 hr. and irradiated with blacklight (peak wavelength 395 nm, light intensity 0.6 mW/cm2) for 5 minutes, the survival rate of clonogenic cells decreased to <10%, while that of bone marrow granulocyte macrophage progenitor cells (CFU-GM) in DBA/2 mice remained at nearly normal level (>80%). Similar results were obtained when human leukemic HL-60 cells were compared with human CFU-GM and mouse leukemic L615 cells with CFU-GM in 615 strain mice. It is suggested that hematoporphyrin photoradiation may be useful for Iselectively killing leukemic cells in bone marrow.
基金supported by the National Natural Science Foundation of China,Nos.82171076(to XS)and U22A20311(to XS),82101168(to TL)Shanghai Science and technology Innovation Action Plan,No.23Y11901300(to JS)+1 种基金Science and Technology Commission of Shanghai Municipality,No.21ZR1451500(to TL)Shanghai Pujiang Program,No.22PJ1412200(to BY)。
文摘Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss.Ferroptosis has been demonstrated to be associated with retinal degenerative diseases.However,the molecular mechanisms underlying ferroptosis and photoreceptor cell death in age-related macular degeneration remain largely unexplored.Bioinformatics and biochemical analyses in this study revealed xC^(–),solute carrier family 7 member 11-regulated ferroptosis as the predominant pathological process of photoreceptor cell degeneration in a light-induced dry age-related macular degeneration mouse model.This process involves the nuclear factor-erythroid factor 2-related factor 2-solute carrier family 7 member 11-glutathione peroxidase 4 signaling pathway,through which cystine depletion,iron ion accumulation,and enhanced lipid peroxidation ultimately lead to photoreceptor cell death and subsequent visual function impairment.We demonstrated that solute carrier family 7 member 11 overexpression blocked this process by inhibiting oxidative stress in vitro and in vivo.Conversely,solute carrier family 7 member 11 knockdown or the solute carrier family 7 member 11 inhibitor sulfasalazine and ferroptosis-inducing agent erastin aggravated H_(2)O_(2)-induced ferroptosis of 661W cells.These findings indicate solute carrier family 7 member 11 may be a potential therapeutic target for patients with retinal degenerative diseases including age-related macular degeneration.
基金supported by the Ministry of Education,Culture,Research,and Technology of the Republic of Indonesia,through the PDUPT 2021 Research Program.
文摘In museum design and operation,daylight is typically discouraged due to high risk of damaging the display objects.However,past studies in high-latitude regions have shown the possibility to apply daylight in museums,so long as it is carefully planned,and the display objects are not from the category of high responsive materials.In the tropical region,the influence of daylighting on light exposure on museum objects is still unknown.This study therefore aims to assess and mitigate the impact of annual daylight exposure on objects with low responsive materials in a tropical daylit museum building.Annual daylight modelling and simulation are performed to achieve the objective,followed with Morris sensitivity analysis and Mahalanobis distance classifier to optimise the outcome.It is found that either WWR or glazing transmissivity gives the greatest influence on the performance indicators.Based on the proposed optimisation algorithm,it is possible to determine the optimum solutions satisfying the performance indicators target,for a certain opening type.Overall,the contribution of this study is the proposed computational modelling and simulation methods to mitigate the exposure risk while optimising daylight as a renewable energy source.
文摘The purpose of this study is to examine how daylight exposure affects the health and well-being of office workers.Sleep actigraphy and health and well-being related survey data were the main dependent variables in this study.Research samples were composed of participants from the United States and South Korea,each set of workers divided into those having daylight at their workplaces and those without.Fifty participants in total wore for two weeks actiwatches equipped with light sensors to measure sleep quality and exposure to ambient light levels.Additional health and well-being measurements were taken using well established survey instruments such as the SF-36 for general and mental health,and the Pittsburg Sleep Quality Index(PSQI)for sleep.In order to estimate the levels of daylight participants were exposed to,computer simulation was used to generate the total annual daylight levels in each participant’s office.Our results seem to indicate that working in daylit office spaces would lead to higher sleep quality and higher scores of the health and well-being scales compared to those who do not work under daylight conditions.Our findings indicate that it is important to provide and maintain significant daylight levels at the workplace.Consequently,in terms of architectural design,building orientation,building dimensions,and the size and height of windows should be taken into consideration to optimize or maximize daylight exposure.
基金supported by the Key Scientific and Technological Grant of Zhejiang for Breeding New Agricultural Varieties(Grant No.2021C12066-4)Huzhou Agricultural Science and Technology Innovation Team Project(Grant No.2022HN01).
文摘Red-fleshed fruits are valued for their vibrant color and high anthocyanin content.Pre-harvest fruit bagging enhances fruit peel pigmentation,but its effect on flesh coloration remains poorly characterized.This study revealed that removing bags from‘Gengcunyangtao’red-fleshed peach fruits triggers the rapid and uniform accumulation of anthocyanins in the flesh,resulting in anthocyanin levels that exceed those in unbagged fruits.The exposure to light after bag removal triggered significant increases in anthocyanin levels within 24 h.This was accompanied by the rapid upregulation of light-responsive and flavonoid biosynthetic gene expression levels within 6 h.A metabolomic analysis indicated that anthocyanin precursors,especially p-coumaric acid,accumulated before bag removal,thereby increasing substrate availability for rapid anthocyanin synthesis.On the basis of a weighted gene co-expression network analysis,MYB transcription factors,anthocyanin transporters,glutathione S-transferase,and multidrug and toxic compound extrusion(MATE)were identified as key regulators that coordinate precursor storage along with light-induced transcriptional activation.Notably,PpMYB4 binds to the promoter of PpGSTF14 and activates its expression,thereby promoting anthocyanin accumulation.The study findings elucidated the temporal coordination of metabolic priming and light-responsive transcriptional regulation driving rapid anthocyanin biosynthesis,with possible implications for improving peach fruit flesh coloration.
基金Supported by the National Natural Science Foundation of China for Young Staff(No.81402695)the Key Discipline of Public Health-Eye Health in Shanghai(No.15GWZK0601)
文摘The purpose of this article is to summarize the methods most commonly used to measure time spent outdoors and provide a comprehensive review of time and activity recording methods with the aim of encouraging the development of new methods. PubMed, Embase and the Cochrane Library were searched from Jan. 1st, 1990 to Aug. 31th, 2017. Studies including the following specific terms： “outdoor”, “outside”, “outdoor activity”, “outside activity”, “outdoor time”, “outside time”, and “outdoor AND measurement of time spent outdoors” were considered for this review. In total, three kinds of outdoor time measurements were discussed. Questionnaires have the longest history and are the most thoroughly revised instruments for assessing time spent outdoors, but recall bias is their most substantial drawback. Global positioning system （GPS） tracking can distinguish between indoor and outdoor locations, but its utility is limited due to several factors such as subject compatibility. Light exposure measurement devices are newly emerging, but all of these devices require good subject cooperation. Further efforts and exploration are needed to develop better methods and new tools to record exposure to the outdoors in real time. Moreover, inventing a new device by combining two or more types of devices mentioned above and using the latest technology of en ergy supplementation and autoswitching may make the best use of the advantages and bypass the disadvantages of each tool.
基金supported by National Autonomous University of Mexico(DGAPAPAPIIT,Research Proyect-IN301414)Ministerio de Educación y Ciencia,Espana(Research Proyect CGL2006-01983/BTE)+1 种基金Ministerio de Ciencia e Innovación,Espana(Research Proyect CGL200907434)Ministerio de Economía y Competitividad,Espana(Research Project CGL2012-35858)
文摘The earliest stages of plant succession on severely disturbed sites usually follow highly unpredictable trajectories. However, in the Popocatépetl volcano area(50 km SE of Mexico City),the development of physiognomically distinct primary plant communities suggests the occurrence of various successional trajectories only 10 years after the onset of colonization of a temperate forest on lahars. To characterize plant communities and determine the environmental factors that drive the differences observed between plant communities and their successional trajectories, we monitored 64 circular sample plots(3.14 m2) from 2002 to 2011. We examined the plant communities' composition and structure in terms of their species richness and abundance, plant cover, and maximum stem height,and recorded 13 environmental factors related to the volcanic deposit characteristics, microclimate, soil,flow dynamics and gravitational processes. A cluster analysis of the species abundance data showed that,by 2011, six plant community types(CT's) had established, including grasslands, and open, dense and very dense shrub lands. As these communities developed over the same period of time and within the same overall ecosystem, then these plant community types were interpreted as different stages of the same successional trajectory. Two sequential main stages that drive regeneration were identified from this successional trajectory: a) the first four years are characterized by a steady increase in species richness and physiognomic development(plant size and coverage), mostly dominated by Baccharis conferta, Eupatorium glabratum and Senecio barbajohannis; b) from the sixth year onwards, a continued increase in the abundance of those same species led to the development of the dense shrubland communities.Differences in the availability of soil resources and disturbances linked to recent lahar flows were the main factors accounting for such differences.
文摘Lateralization of cognitive functions influences a large number of fitness-related behaviors and shows,in most species,substantial variation in strength and direction.Laboratory works and field data have suggested that this variation is often due to adaptive phenotypic plasticity.Strong lateralization should be favored in some ecological conditions,for example,under high risk of predation.For anuran tadpoles,the presence of cover affects predation risk,with tadpoles being more exposed to predators in environments with reduced cover.We tested the hypothesis that the amount of cover experienced early in life affects lateralization in the edible frog,Pelophylax escu-lentus,tadpoles.We exposed embryos and larvae to high or low vegetation cover environments.For half of the subjects,the treatment was constant whereas the remaining subjects were switched to the opposite treatment after hatching.In agreement with the theoretical expectation,tadpoles exposed to low vegetation cover for the entire development were more lateralized and showed a stronger alignment in directionality of lateralization compared with tadpoles exposed to high vege-tation cover.This indicates a possible role of natural variation in vegetation abundance and deve卜opmental plasticity as determinants of between-population and between-individual differences in lateralization.We also found that shifting from high to low vegetation cover treatments and vice versa disrupted lateralization alignment,suggesting that developmental trajectories for this trait are determined at the embryonic stage and need environmental stability to be fully expressed.
基金funded by the National Key R&D Program of China(Project No.2017YFB0403700)the Shanghai Municipal Science and Technology Major Project(Grant No.2017SHZDZX01).
文摘Light is an important external factor that affects human circadian rhythms.This study aimed to explore the effects of different dimensions of diurnal light exposure on the physiological circadian phase shift(CPS)of the human body.A strict light exposure experiment with different timing schemes(8:00-12:00,13:00-17:00,18:00-22:00),durations(4 h,8 h)and effective circadian stimulus levels(circadian stimulus:0.35,0.55)was performed in an enclosed laboratory.Fourteen participants,including seven males and seven females,with a mean age of 24.29±2.43(mean±standard deviation),participated in this experiment and experienced all six lighting schemes.The results showed that both time factor(F_(3,40)=29.079,p<0.001,the power of the sample size=0.98)and circadian stimulus levels(T_(20)=−2.415,p=0.025,the power of sample size=0.76)sig-nificantly affect the CPS.On this basis,a diurnal circadian lighting accumulation(DCLA)-CPS model was proposed in the form of the Boltzmann function,and was validated by experimental data with high correlation(R^(2)=0.9320,RSS=0.1184),which provides strong support for rationally arranging the light level at different times of the day.
