Background:Based on a profound awareness of crisis sense,Huai Nan-zi warns people of the importance of being prepared for danger in times of peace by using the principle that Heaven and Earth are ever-changing and nev...Background:Based on a profound awareness of crisis sense,Huai Nan-zi warns people of the importance of being prepared for danger in times of peace by using the principle that Heaven and Earth are ever-changing and never-ending.It also consciously constructs a cosmic life view of the organic,homologous,isomorphic,and harmonious unity of heaven,earth,and man based on human existence and destiny with a rational thinking attitude.The life philosophy of the Huai Nan-zi offers modern people a completely new holistic view of life and medicine.Not only in China,but also in Western countries,studying its medical philosophical ideas helps us better explore the theoretical roots of TCM in the era of globalized medicine.Methods:This paper mainly uses the analysis method of literature review and chinese philosophy intellectual concepts.It employs the I Ching’s image-number logic thinking method to compare images through analogy and the holistic thinking method of the three-talent view of heaven,earth,and human to understand life consciousness.Results:This article mainly interprets medical philosophy in Huai Nan-zi through three aspects:1)The body of Taoism:heaven,earth,and humanity constitute one unity within the body of the universe;2)The spirit of Taoism:keeping the spirit inward,preserving the essence and suppressing the superficial;and 3)The mind of Taoism:the principle of life governed by the dynamics of gain and loss,prosperity and decline.Conclusion:The philosophy of life presented in the Huai Nan-zi ultimately charts a course toward a state of profound theoretical integration.Its“conscious map”does not lead to a fixed destination,but to a continuous and dynamic mode of being–a life of flourishing known in Chinese as yang sheng,the nurturing of life.The destination,therefore,is the journey itself,undertaken with unwavering cosmic awareness and harmony.This ancient text reminds us that a truly healthy life is not a fragmented pursuit of physical fitness,mental peace,or spiritual insight in isolation.Instead,it is the symphony of all three(Taoist body,spirit,and mind),orchestrated by the fundamental principles of the cosmos.By aligning our inner nature with the outer Tao,we transform our existence from a series of reactive struggles into a graceful and spontaneous free flow.In a modern world characterized by fragmentation,overstimulation,and a relentless push against natural rhythms,the Huai Nan-zi’s life consciousness map is more relevant than ever.The philosophy of Huai Nan-zi not only plays a vital role in the construction of the theoretical system of TCM in ancient East life wisdom,but also is worthwhile for Western life sciences to conduct in-depth exploration and discovery in the age of AI.展开更多
BACKGROUND Approximately 30%of patients with head and neck cancer experience adverse effects caused by anxiety and depression.Considering the high prevalence,implementing customized interventions to ease adverse emoti...BACKGROUND Approximately 30%of patients with head and neck cancer experience adverse effects caused by anxiety and depression.Considering the high prevalence,implementing customized interventions to ease adverse emotional states is imperative.AIM To evaluate the efficacy of cognitive behavioral therapy(CBT)-based psychological interventions in improving the psychological well-being and quality of life(QoL)of patients with laryngeal carcinoma.METHODS This study enrolled 120 patients admitted from February 2022 to February 2024.The control group,comprising 50 participants,received standard supportive psychological care,while the research group,consisting 70 participants,underwent CBT-based interventions.Several clinical outcomes were systematically assessed that included postoperative recovery metrics(duration of tracheostomy and nasogastric tube dependence and length of hospitalization),psychological status(Self-Rating Anxiety Scale and Self-Rating Depression Scale),nutritional markers(serum albumin and hemoglobin levels),sleep quality(Self-Rating Scale of Sleep and Athens Insomnia Scale),and QoL(Functional Assessment of Cancer Therapy-Head and Neck).RESULTS The results demonstrated that the research group experienced superior outcomes,with significantly reduced durations of tracheostomy and nasogastric tube dependence,as well as shorter hospital stays,compared with the control group.Additionally,the research group exhibited markedly lower post-intervention Self-Rating Anxiety Scale,Self-Rating Depression Scale,Self-Rating Scale of Sleep,and Athens Insomnia Scale scores,along with minimal but higher change in serum albumin and hemoglobin levels compared with the control group.All five domains of Functional Assessment of Cancer Therapy-Head and Neck showed notable improvements in the research group,exceeding those observed in the control group.CONCLUSION CBT-based psychological support positively affects the mental well-being and QoL of patients with laryngeal carcinoma,highlighting its potential for broader clinical application.展开更多
Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily...Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily involving abnormal development and damage of the dopaminergic system,pose significant public health challenges.Microglia,as the primary immune cells in the brain,are crucial in regulating neuronal circuit development and survival.From the embryonic stage to adulthood,microglia exhibit stage-specific gene expression profiles,transcriptome characteristics,and functional phenotypes,enhancing the susceptibility to early life stress.However,the role of microglia in mediating dopaminergic system disorders under early life stress conditions remains poorly understood.This review presents an up-to-date overview of preclinical studies elucidating the impact of early life stress on microglia,leading to dopaminergic system disorders,along with the underlying mechanisms and therapeutic potential for neurodegenerative and neurodevelopmental conditions.Impaired microglial activity damages dopaminergic neurons by diminishing neurotrophic support(e.g.,insulin-like growth factor-1)and hinders dopaminergic axon growth through defective phagocytosis and synaptic pruning.Furthermore,blunted microglial immunoreactivity suppresses striatal dopaminergic circuit development and reduces neuronal transmission.Furthermore,inflammation and oxidative stress induced by activated microglia can directly damage dopaminergic neurons,inhibiting dopamine synthesis,reuptake,and receptor activity.Enhanced microglial phagocytosis inhibits dopamine axon extension.These long-lasting effects of microglial perturbations may be driven by early life stress–induced epigenetic reprogramming of microglia.Indirectly,early life stress may influence microglial function through various pathways,such as astrocytic activation,the hypothalamic–pituitary–adrenal axis,the gut–brain axis,and maternal immune signaling.Finally,various therapeutic strategies and molecular mechanisms for targeting microglia to restore the dopaminergic system were summarized and discussed.These strategies include classical antidepressants and antipsychotics,antibiotics and anti-inflammatory agents,and herbal-derived medicine.Further investigations combining pharmacological interventions and genetic strategies are essential to elucidate the causal role of microglial phenotypic and functional perturbations in the dopaminergic system disrupted by early life stress.展开更多
To address the challenges posed by tunnel construction in the alpine region,silica fume mixed concrete is commonly used as a construction material.The correlation between silica fume content and the lining life requir...To address the challenges posed by tunnel construction in the alpine region,silica fume mixed concrete is commonly used as a construction material.The correlation between silica fume content and the lining life requires immediate investigation.In view of this phenomenon,the durability of unit lining concrete is predicted by analyzing three key indicators:carbonation depth,relative dynamic elastic modulus,and residual quality.This prediction is achieved by integrating the Entropy Weight Method,Grey theory life prediction model and BP artificial neural networks using data from tests and predictions of these indicators.Then,the Entropy Weight-Grey theory-BP Network Model is compared with other methods to analyze the predicted life.Finally,verify the sci-entificity of this model,and the optimum silica fume content of unit concrete lining is verified.The results showed,1)The addition of silica fume will accelerate the carbonization of unit concrete lining,and slow down the freeze-thaw cycle and sulfate erosion.2)The utilization of artificial neural networks is essential for enhancing the realism of the data,as it emphasizes the significance of silica fume content.3)Silica fume content of 10%results in the longest life and is the most suitable for lining construction.4)A comparison between single-factor and multi-factor predictions indicates that the multi-factor approach yields a longer maximum life.This improvement can be attributed to the inclusion of additional factors,such as freeze-thaw cycles and carbonation,which enhance the predicted life when employing these methods.In conclusion,the Entropy Weight-Grey Theory-BP Network life prediction Model is well-suited for tunnel lining in the alpine sulfate area of northwest China.展开更多
As mining activities expand deeper,deep high-temperature formations seriously threaten the future safe exploitation,while deep geothermal energy has great potential for development.Combining the formation cooling and ...As mining activities expand deeper,deep high-temperature formations seriously threaten the future safe exploitation,while deep geothermal energy has great potential for development.Combining the formation cooling and geothermal mining in mines to establish a thermos-hydraulic coupling numerical model for fractured formation.The study investigates the formation heat transfer behaviour,heat recovery performance and thermal economic benefits influenced during the life cycle.The results show that the accumulation of cold energy during the cold storage phase induces a decline in formation temperature.The heat recovery phase is determined by the extent of the initial cold domain,which contracts inward from the edge and decelerates the heat recovery rate gradually.With groundwater velocity increases,the thermal regulation efficiency gradually increases,the production temperature decreases,while the effective radius and thermal power increase first and then decrease.The injected volume and temperature significantly affect,with higher injection temperatures slowing thermal recovery,and the thermal regulation efficiency is more sensitive to changes in formation permeability and thermal conductivity.The heat extraction performance is positively correlated with all factors.The levelized cost of electricity is estimated at 0.1203$/(kW·h)during the cold storage.During the heat recovery,annual profit is primarily driven by cooling benefits.展开更多
In 1993,the World Bank released a global report on the efficacy of health promotion,introducing the disability-adjusted life years(DALY)as a novel indicator.The DALY,a composite metric incorporating temporal and quali...In 1993,the World Bank released a global report on the efficacy of health promotion,introducing the disability-adjusted life years(DALY)as a novel indicator.The DALY,a composite metric incorporating temporal and qualitative data,is grounded in preferences regarding disability status.This review delineates the algorithm used to calculate the value of the proposed DALY synthetic indicator and elucidates key methodological challenges associated with its application.In contrast to the quality-adjusted life years approach,derived from multi-attribute utility theory,the DALY stands as an independent synthetic indicator that adopts the assumptions of the Time Trade Off utility technique to define Disability Weights.Claiming to rely on no mathematical or economic theory,DALY users appear to have exempted themselves from verifying whether this indicator meets the classical properties required of all indicators,notably content validity,reliability,specificity,and sensitivity.The DALY concept emerged primarily to facilitate comparisons of the health impacts of various diseases globally within the framework of the Global Burden of Disease initiative,leading to numerous publications in international literature.Despite widespread adoption,the DALY synthetic indicator has prompted significant methodological concerns since its inception,manifesting in inconsistent and non-reproducible results.Given the substantial diffusion of the DALY indicator and its critical role in health impact assessments,a reassessment is warranted.This reconsideration is imperative for enhancing the robustness and reliability of public health decisionmaking processes.展开更多
中国语际翻译的历史最早可以追溯到西汉时期,但当时翻译的主要内容都是佛经,直到清朝才出现了第一首被译成中文的英语诗歌——A Psalm of Life。而清朝至今,这首诗已有多个译本。在20世纪70年代,德国学者凯瑟琳娜·赖斯在其著作《...中国语际翻译的历史最早可以追溯到西汉时期,但当时翻译的主要内容都是佛经,直到清朝才出现了第一首被译成中文的英语诗歌——A Psalm of Life。而清朝至今,这首诗已有多个译本。在20世纪70年代,德国学者凯瑟琳娜·赖斯在其著作《翻译批评——潜力与制约》中,提出了以文本类型为导向,结合语言内因素(语言范畴)、语言外因素(语用范畴)和功能因素(功能范畴)的翻译批评模式。因此,基于赖斯的翻译批评模式,文章从文本类型、语言范畴、语用范畴和功能范畴四方面对黄新渠、黄杲炘和黄一宁三人的译本进行对比赏析。通过分析发现,三人的译本基本都再现了原文的内容和风格,句式、节奏上也基本与原文保持一致;而在语义、词汇、语法和文体上,每一译本都有其各自的优点。此外,译本的语用和功能因素也显著影响了翻译策略的选择。展开更多
High-rise housing is being built in increasingly densely populated urban residential areas in Tokyo,Japan.On the other hand,detached houses are built on small,subdivided sites.In urban residential areas where detached...High-rise housing is being built in increasingly densely populated urban residential areas in Tokyo,Japan.On the other hand,detached houses are built on small,subdivided sites.In urban residential areas where detached houses are lined up,many elements related to daily life are located near roadside space and spill out onto the road.This is a distinctive modern urban residential landscape.The purpose of this study is to get closer to the reality of urban residential life.For that,we will consider the characteristics and roles of elements related to daily life that can be observed in many areas around roadside space in an urban residential area lined with detached houses,in urban living environments.This study focuses on the detached residential area of Bunkyo Ward.A field survey will be conducted to investigate the amount of elements related to daily life that can be observed from the road.In addition,we will conduct a questionnaire survey of residents in the survey area regarding their use of and awareness of the roadside space.Finally,we will investigate the relationship between lifestyle factors and urban residential life from both quantitative and qualitative perspectives.展开更多
In this paper Cheng Yanqiu’s personality,manliness and his hobbies are discussed.From the narration of his farming life in the 1940s and his founding of schools his view on life is to be seen.In the latter part of th...In this paper Cheng Yanqiu’s personality,manliness and his hobbies are discussed.From the narration of his farming life in the 1940s and his founding of schools his view on life is to be seen.In the latter part of the paper the artistic achievements of his masterpiece“The Lucky Purse”are explored.展开更多
Engineering systems such as aero-engines have the characteristics of complex structural geometries,diverse material types and variable load spectra,which pose great challenges for predicting the service life of practi...Engineering systems such as aero-engines have the characteristics of complex structural geometries,diverse material types and variable load spectra,which pose great challenges for predicting the service life of practical engineering structures.In this regard,a novel stress fatigue life prediction model applicable to the whole life stage and complex stress states has been developed.The novel model and the widely used total strain life prediction model were used to predict the fatigue life of specimens with various alloys(TC4.TC17,FGH95,GH907.DZ125 and GH4169)and notch geometries(K_(t)=1 and K_(t)=3)as well as stress ratios(R=-1,R=0.1 and R=0.5).The results show that the novel model is applicable to the whole life stage with satisfactory life prediction accuracy,thus having greater potential in engineering applications.Furthermore,the novel model was also applied to predict the fatigue life of the bridge-type pad and plate specimen contact component within±2 dispersion band.展开更多
Background The effectiveness of life skills-based prevention programs to prevent substance addiction has been underexplored in Türkiye,likely in part due to the lack of validated measurement tools developed speci...Background The effectiveness of life skills-based prevention programs to prevent substance addiction has been underexplored in Türkiye,likely in part due to the lack of validated measurement tools developed specifically for that purpose.Therefore,the aim of this study is to develop a tool to measure life skills for middle school students.The present study aims to test the factorial structure,reliability,convergent and discriminant validity,and measurement invariance across gender and age groups of the Green Crescent Life Skills(GCLS)Scale.Methods The study was conducted in Istanbul with two different sample groups.The first sample consisted of 566 and the second sample consisted of 885 middle school students.In the study,exploratory factor analysis(EFA)was applied to the first sample,and confirmatory factor analysis(CFA)was applied to the second sample to test the factorial structure of the scale.Convergent and discriminant validity were examined to provide evidence for construct-based validity.The reliability of the scale was assessed with Cronbach’sα,composite reliability,McDonald’sω,and test-retest.Results The EFA results showed that the scale consisted of four factors(self-awareness,coping with negative emotions,thinking skills,and peer relations).CFA results also confirmed this structure.The results revealed a significant positive correlation(r=0.52,p<0.01)between life skills and avoidance self-efficacy scores,as well as a significant negative correlation(r=−0.53,p<0.01)between life skills and attitude toward drug use scores.Additionally,it was found that measurement invariances based on gender and age groups were provided.It was determined that all sub-dimensions had sufficient reliability levels.Conclusion The findings of this validation study show that the GCLS Scale,which assesses four skills in a self-reported format,is a valid and reliable scale with considerable potential utility in monitoring life skills in Turkish adolescent populations.展开更多
The article contains a list of 14 structured technical sheets on roots, rhizomes or tubers that will serve as guidance in improving the quality of health of people. The used method was through an active search for lit...The article contains a list of 14 structured technical sheets on roots, rhizomes or tubers that will serve as guidance in improving the quality of health of people. The used method was through an active search for literature that brought the observed aspects to the structuring of the technical sheets, i.e., literature that contains data related to composition, active ingredients, interaction (when described in the consulted literature), health condition in which they may be useful in helath care by various health professionals and anyone who may be of interest. The data obtained shows that there is a need for a careful evaluation of the foods (that contain roots, rhizomes, or tubers) used by polymedicated people due to possible interactions and incompatibilities that may exist.展开更多
BACKGROUND Insomnia is a common sleep disorder that negatively impacts quality of life and is frequently comorbid with depression and anxiety.Chronic insomnia affects approximately 15%of the global population,with hig...BACKGROUND Insomnia is a common sleep disorder that negatively impacts quality of life and is frequently comorbid with depression and anxiety.Chronic insomnia affects approximately 15%of the global population,with higher prevalence among females and the elderly.While existing research suggests a bidirectional relationship between insomnia and emotional disorders,the specific impact of insomnia severity on depression,anxiety,and quality of life remains unclear.This study investigates the correlation between insomnia severity and these factors in psychiatric outpatients,hypothesizing that greater insomnia severity is associated with higher levels of depression and anxiety,as well as poorer quality of life.AIM To explore the correlation between insomnia severity and depression,anxiety,and quality of life in primary chronic insomnia patients.METHODS From June to December 2023,345 patients with primary insomnia in Chifeng city were recruited and divided into three groups based on Pittsburgh sleep quality index(PSQI)scores:Mild(n=137),moderate(n=162),and severe(n=46).Demographic data were collected via questionnaires.Self-rating depression scale(SDS),self-rating anxiety scale(SAS),PSQI,and short form 36(SF-36)scores were compared,and Pearson and partial correlation analyses were performed.RESULTS The greater the degree of insomnia,the greater the symptoms of depression and anxiety(P<0.001).The more severe the insomnia,the lower the SF-36 score(excluding body pain),and the difference between the three groups was statist ically significant(P<0.001).Pearson correlation analysis and partial correlation analysis depicted the SDS score and SAS score were apparently positively correlated with the severity of insomnia(P<0.001).Pearson correlation analysis and partial correlation analysis depicted the SF-36 scores were apparently positively correlated with the severity of insomnia(P<0.05).CONCLUSION Depression and anxiety are independent factors influencing insomnia severity in primary chronic insomnia patients.Higher depression/anxiety levels correlate with worse insomnia,impacting quality of life.展开更多
Polymethyl methacrylate(PMMA)has the advantages of good transparency,corrosion resistance and light weight and can be used as the preferred material for pressure-resistant cabins of fully transparent submersibles.In t...Polymethyl methacrylate(PMMA)has the advantages of good transparency,corrosion resistance and light weight and can be used as the preferred material for pressure-resistant cabins of fully transparent submersibles.In this study,based on the fracture mechanics method,a calculation method for estimating the residual fatigue life of a PMMA manned cabin is proposed by improving the small-time scale fatigue crack growth rate model.This improved model is verified by the experimental data of the PMMA material.Then,through the Weibull and Gumbel combined distribution functions,the fatigue load spectrum suitable for the fully transparent manned cabin is fitted according to the dive data.A parametric analysis of the residual fatigue life of the fully transparent manned cabin under various initial crack sizes and dwell time is conducted,yielding valuable results.This study aims to increase the safety of fully transparent pressure-resistant cabins and offer insights for fatigue analysis of underwater structures utilizing PMMA materials.展开更多
Objective This study examines the sequential mediating roles of body pain and self-reported health in the association between sleep duration and self-reported life satisfaction among elderly Chinese adults.Methods Dat...Objective This study examines the sequential mediating roles of body pain and self-reported health in the association between sleep duration and self-reported life satisfaction among elderly Chinese adults.Methods Data from the fifth wave of the China Health and Retirement Longitudinal Survey(CHARLS)were used to analyse the relationships between sleep duration and body pain,self-reported health,and life satisfaction through logistic regression and Restricted Cubic Spline(RCS)analyses.The sequential mediation effects of body pain and self-reported health status were examined via chain mediation analysis.Results Logistic regression analysis showed that sleeping fewer than 6 hours or 6-7 hours was linked to higher risks of body pain,poor health,and dissatisfaction with life compared to sleeping 7-8 hours(all P<0.05).Additionally,those sleeping more than 9 hours also had increased risks of poor health and dissatisfaction with life compared to those sleeping 7-8 hours(all P<0.05).Chain mediation analysis showed that body pain and self-reported health status sequentially mediated 46.15%of the association between sleep duration and life satisfaction.Conclusion Body pain and self-reported health may shape the relationship between sleep duration and life satisfaction in elderly Chinese adults.展开更多
Objective:This study aimed to summarize the quality of life experiences of individuals with physical frailty undergoing hemodialysis or peritoneal dialysis and to identify the difficultiesand resources that enable bet...Objective:This study aimed to summarize the quality of life experiences of individuals with physical frailty undergoing hemodialysis or peritoneal dialysis and to identify the difficultiesand resources that enable better person-centered health care.Methods:The study described is a qualitative meta-synthesis literature review.The search was performed in databases such as CINAHL,Scopus,PubMed,Web of Science,the Cochrane Library,and Cuiden Plus through Medical Subject Headings and free terms.Qualitative and mixed studies were included on individuals undergoing hemodialysis or peritoneal dialysis,18 years of age or older,published in English or Spanish,between January 2013 and January 2024.The Mixed Methods Appraisal Tool was used to assess the methodological quality.The information was analyzed and coded through a socioecological model and the social determinants of health.Results:Fourteen qualitative and two mixed articles were selected.A total of 256 individuals participated in the study.Seventeen themes and 25 sub-themes were identifiedand grouped into two blocks(difficulties and resources).The difficultiesthat stood out were a low tolerance for activities of daily living and physical activity,loss of self-control over life and social roles,and lack of community and public resources.As for the resources,the following was found:the positive meaning of dialysis,the safety offered by close individuals and the healthcare team,the activation of specificprograms,and person-centered policies.Conclusions:The analysis and interpretation of the identifieddifficultiesand resources revealed key elements to consider when designing and implementing health programs for individuals undergoing dialysis.Future research should explore these dimensions in diverse cultural and geographical contexts to enhance generalizability and support health equity.展开更多
Food breakdown during storage and transit greatly adds to worldwide food waste.Biodegradable edible coatings derived from natural sources provide a sustainable method to extend the shelf life and preserve the freshnes...Food breakdown during storage and transit greatly adds to worldwide food waste.Biodegradable edible coatings derived from natural sources provide a sustainable method to extend the shelf life and preserve the freshness of fresh fruit.This study explores the potential of the readily available and nutrient-rich seaweed,Caulerpa lentillifera,as a base material for edible coatings that can enhance the shelf life and maintain the physicochemical properties of fruits and vegetables.Caulerpa lentillifera,a marine macroalga renowned for its unique biochemical composition,presents a promising avenue for developing sustainable bio-coatings to improve the post-harvest quality of fresh produce.Biodegradable edible coatings derived from natural sources provide a sustainable method to extend the shelf life and preserve the freshness of fresh fruit.This study is aimed at exploring the potential of Caulerpa lentillifera,a nutrient-dense green seaweed,as a foundational material for creating edible coatings to enhance the post-harvest quality of fruits and vegetables.Various Caulerpa lentillifera-derived coating formulations were developed and applied to specific fruits and vegetables.The coated samples were maintained under controlled conditions and assessed for alterations in physicochemical parameters,including weight loss,hardness,colour,and microbial proliferation.The optimised coating formulation markedly diminished weight loss,postponed ripening,and maintained firmness and colour relative to uncoated controls.The coating demonstrated promising antibacterial properties,aiding in the extension of shelf life.Coatings derived from Caulerpa lentillifera offer a viable,environmentally sustainable alternative to synthetic preservatives,facilitating the advancement of sustainable food preservation technology.展开更多
This paper critically re-examines the anthropocentric“Goldilocks Zone”paradigm that has dominated the search for extraterrestrial life.As of 2024,more than 5,500 exoplanets have been identified,yet only about 2%are ...This paper critically re-examines the anthropocentric“Goldilocks Zone”paradigm that has dominated the search for extraterrestrial life.As of 2024,more than 5,500 exoplanets have been identified,yet only about 2%are located within the traditionally defined habitable zone(National Aeronautics and Space Administration(NASA)Exoplanet Archive,2024;Kane et al.,2023).Moreover,the discovery of extremophiles-organisms thriving in high-radiation,extreme heat,or vacuum environments-demonstrates that the boundaries of life far exceed Earth-like conditions(Rothschild&Mancinelli,2001).展开更多
BACKGROUND Cardiovascular health(CVH)plays a crucial role in overall health,but its association with metabolic-associated fatty liver disease(MAFLD)remains unclear.AIM To investigate the relationship between CVH,measu...BACKGROUND Cardiovascular health(CVH)plays a crucial role in overall health,but its association with metabolic-associated fatty liver disease(MAFLD)remains unclear.AIM To investigate the relationship between CVH,measured using Life’s Essential 8(LE8)and Life’s Simple 7(LS7),and the prevalence of MAFLD.METHODS This cross-sectional study had a sample of 2234 individuals,representing approximately 120 million individuals in the United States.Baseline parameters were compared between the LE8 and LS7 groups.Logistic regression models were used to evaluate the relationship between LE8,LS7,and MAFLD,while taking into account confounding factors.The investigation employed restricted cubic splines to investigate non-linear associations.Subgroup analyses and sensitivity studies were performed to evaluate the strength and reliability of the results.RESULTS Higher LE8 and LS7 scores were significantly associated with a decreased risk of MAFLD,even after controlling for demographic,socioeconomic,and clinical variables.This association demonstrated a non-linear pattern,with the most dramatic risk reduction observed at higher CVH levels.Individual CVH components,notably healthy behaviors and factors,exhibited strong relationships with MAFLD.Subgroup analyses indicated consistent relationships across several demographics.Sensitivity tests utilizing other MAFLD definitions validated the robustness of the findings.CONCLUSION Higher adherence to CVH criteria,as indicated by LE8 and LS7 scores,is associated with a significantly lower risk of MAFLD.These results emphasize the need to advance CVH to control and avoid MAFLD.展开更多
This study examined the mediating role of job satisfaction in explaining the relationship between work-family conflict and life satisfaction among Turkish academicians.Employing a cross-sectional study design 645 acad...This study examined the mediating role of job satisfaction in explaining the relationship between work-family conflict and life satisfaction among Turkish academicians.Employing a cross-sectional study design 645 academicians aged between 24 and 65(male=45.1%,female=54.9%;professors=12.1%,associate professors=17.7%,assistant professors=28.2%,lecturers=17.8%,research assistants=24.2%;mean age and SD=39.72±8.94)completed the Job Satisfaction Scale,Life Satisfaction Scale,and the Work-Family Conflict Scale.They also self-reported their demographics.The findings from PROCESS MACRO analysis indicated work-family conflict to predict lower job satisfaction among academicians.Those with higher job satisfaction were also self-reported with higher life satisfaction.Lob satisfaction mediated the relationship between the academician’s work family conflict and life satisfaction for higher life satisfaction.The findings of this study indicate a need to implement work-family and life satisfaction measures to enhance job satisfaction among academics.展开更多
基金funded by the National Social Science Foundation project“Research on Chinese Life Wisdom from the Perspective of Creative Transformation and Innovative Development”(22ZDA082).
文摘Background:Based on a profound awareness of crisis sense,Huai Nan-zi warns people of the importance of being prepared for danger in times of peace by using the principle that Heaven and Earth are ever-changing and never-ending.It also consciously constructs a cosmic life view of the organic,homologous,isomorphic,and harmonious unity of heaven,earth,and man based on human existence and destiny with a rational thinking attitude.The life philosophy of the Huai Nan-zi offers modern people a completely new holistic view of life and medicine.Not only in China,but also in Western countries,studying its medical philosophical ideas helps us better explore the theoretical roots of TCM in the era of globalized medicine.Methods:This paper mainly uses the analysis method of literature review and chinese philosophy intellectual concepts.It employs the I Ching’s image-number logic thinking method to compare images through analogy and the holistic thinking method of the three-talent view of heaven,earth,and human to understand life consciousness.Results:This article mainly interprets medical philosophy in Huai Nan-zi through three aspects:1)The body of Taoism:heaven,earth,and humanity constitute one unity within the body of the universe;2)The spirit of Taoism:keeping the spirit inward,preserving the essence and suppressing the superficial;and 3)The mind of Taoism:the principle of life governed by the dynamics of gain and loss,prosperity and decline.Conclusion:The philosophy of life presented in the Huai Nan-zi ultimately charts a course toward a state of profound theoretical integration.Its“conscious map”does not lead to a fixed destination,but to a continuous and dynamic mode of being–a life of flourishing known in Chinese as yang sheng,the nurturing of life.The destination,therefore,is the journey itself,undertaken with unwavering cosmic awareness and harmony.This ancient text reminds us that a truly healthy life is not a fragmented pursuit of physical fitness,mental peace,or spiritual insight in isolation.Instead,it is the symphony of all three(Taoist body,spirit,and mind),orchestrated by the fundamental principles of the cosmos.By aligning our inner nature with the outer Tao,we transform our existence from a series of reactive struggles into a graceful and spontaneous free flow.In a modern world characterized by fragmentation,overstimulation,and a relentless push against natural rhythms,the Huai Nan-zi’s life consciousness map is more relevant than ever.The philosophy of Huai Nan-zi not only plays a vital role in the construction of the theoretical system of TCM in ancient East life wisdom,but also is worthwhile for Western life sciences to conduct in-depth exploration and discovery in the age of AI.
文摘BACKGROUND Approximately 30%of patients with head and neck cancer experience adverse effects caused by anxiety and depression.Considering the high prevalence,implementing customized interventions to ease adverse emotional states is imperative.AIM To evaluate the efficacy of cognitive behavioral therapy(CBT)-based psychological interventions in improving the psychological well-being and quality of life(QoL)of patients with laryngeal carcinoma.METHODS This study enrolled 120 patients admitted from February 2022 to February 2024.The control group,comprising 50 participants,received standard supportive psychological care,while the research group,consisting 70 participants,underwent CBT-based interventions.Several clinical outcomes were systematically assessed that included postoperative recovery metrics(duration of tracheostomy and nasogastric tube dependence and length of hospitalization),psychological status(Self-Rating Anxiety Scale and Self-Rating Depression Scale),nutritional markers(serum albumin and hemoglobin levels),sleep quality(Self-Rating Scale of Sleep and Athens Insomnia Scale),and QoL(Functional Assessment of Cancer Therapy-Head and Neck).RESULTS The results demonstrated that the research group experienced superior outcomes,with significantly reduced durations of tracheostomy and nasogastric tube dependence,as well as shorter hospital stays,compared with the control group.Additionally,the research group exhibited markedly lower post-intervention Self-Rating Anxiety Scale,Self-Rating Depression Scale,Self-Rating Scale of Sleep,and Athens Insomnia Scale scores,along with minimal but higher change in serum albumin and hemoglobin levels compared with the control group.All five domains of Functional Assessment of Cancer Therapy-Head and Neck showed notable improvements in the research group,exceeding those observed in the control group.CONCLUSION CBT-based psychological support positively affects the mental well-being and QoL of patients with laryngeal carcinoma,highlighting its potential for broader clinical application.
基金supported by the National Natural Science Foundation of China,Nos.82304990(to NY),81973748(to JC),82174278(to JC)the National Key R&D Program of China,No.2023YFE0209500(to JC)+4 种基金China Postdoctoral Science Foundation,No.2023M732380(to NY)Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine,No.202102010014(to JC)Huang Zhendong Research Fund for Traditional Chinese Medicine of Jinan University,No.201911(to JC)National Innovation and Entrepreneurship Training Program for Undergraduates in China,No.202310559128(to NY and QM)Innovation and Entrepreneurship Training Program for Undergraduates at Jinan University,Nos.CX24380,CX24381(both to NY and QM)。
文摘Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily involving abnormal development and damage of the dopaminergic system,pose significant public health challenges.Microglia,as the primary immune cells in the brain,are crucial in regulating neuronal circuit development and survival.From the embryonic stage to adulthood,microglia exhibit stage-specific gene expression profiles,transcriptome characteristics,and functional phenotypes,enhancing the susceptibility to early life stress.However,the role of microglia in mediating dopaminergic system disorders under early life stress conditions remains poorly understood.This review presents an up-to-date overview of preclinical studies elucidating the impact of early life stress on microglia,leading to dopaminergic system disorders,along with the underlying mechanisms and therapeutic potential for neurodegenerative and neurodevelopmental conditions.Impaired microglial activity damages dopaminergic neurons by diminishing neurotrophic support(e.g.,insulin-like growth factor-1)and hinders dopaminergic axon growth through defective phagocytosis and synaptic pruning.Furthermore,blunted microglial immunoreactivity suppresses striatal dopaminergic circuit development and reduces neuronal transmission.Furthermore,inflammation and oxidative stress induced by activated microglia can directly damage dopaminergic neurons,inhibiting dopamine synthesis,reuptake,and receptor activity.Enhanced microglial phagocytosis inhibits dopamine axon extension.These long-lasting effects of microglial perturbations may be driven by early life stress–induced epigenetic reprogramming of microglia.Indirectly,early life stress may influence microglial function through various pathways,such as astrocytic activation,the hypothalamic–pituitary–adrenal axis,the gut–brain axis,and maternal immune signaling.Finally,various therapeutic strategies and molecular mechanisms for targeting microglia to restore the dopaminergic system were summarized and discussed.These strategies include classical antidepressants and antipsychotics,antibiotics and anti-inflammatory agents,and herbal-derived medicine.Further investigations combining pharmacological interventions and genetic strategies are essential to elucidate the causal role of microglial phenotypic and functional perturbations in the dopaminergic system disrupted by early life stress.
基金funded by the Technology Funding Scheme of China Construction Second Engineering Bureau LTD(2020ZX150002)the National Natural Science Foundation Project of China(12262018).
文摘To address the challenges posed by tunnel construction in the alpine region,silica fume mixed concrete is commonly used as a construction material.The correlation between silica fume content and the lining life requires immediate investigation.In view of this phenomenon,the durability of unit lining concrete is predicted by analyzing three key indicators:carbonation depth,relative dynamic elastic modulus,and residual quality.This prediction is achieved by integrating the Entropy Weight Method,Grey theory life prediction model and BP artificial neural networks using data from tests and predictions of these indicators.Then,the Entropy Weight-Grey theory-BP Network Model is compared with other methods to analyze the predicted life.Finally,verify the sci-entificity of this model,and the optimum silica fume content of unit concrete lining is verified.The results showed,1)The addition of silica fume will accelerate the carbonization of unit concrete lining,and slow down the freeze-thaw cycle and sulfate erosion.2)The utilization of artificial neural networks is essential for enhancing the realism of the data,as it emphasizes the significance of silica fume content.3)Silica fume content of 10%results in the longest life and is the most suitable for lining construction.4)A comparison between single-factor and multi-factor predictions indicates that the multi-factor approach yields a longer maximum life.This improvement can be attributed to the inclusion of additional factors,such as freeze-thaw cycles and carbonation,which enhance the predicted life when employing these methods.In conclusion,the Entropy Weight-Grey Theory-BP Network life prediction Model is well-suited for tunnel lining in the alpine sulfate area of northwest China.
基金financial support from the National Natural Science Foundation of China(Nos.52434006,52374151,and 51927808)。
文摘As mining activities expand deeper,deep high-temperature formations seriously threaten the future safe exploitation,while deep geothermal energy has great potential for development.Combining the formation cooling and geothermal mining in mines to establish a thermos-hydraulic coupling numerical model for fractured formation.The study investigates the formation heat transfer behaviour,heat recovery performance and thermal economic benefits influenced during the life cycle.The results show that the accumulation of cold energy during the cold storage phase induces a decline in formation temperature.The heat recovery phase is determined by the extent of the initial cold domain,which contracts inward from the edge and decelerates the heat recovery rate gradually.With groundwater velocity increases,the thermal regulation efficiency gradually increases,the production temperature decreases,while the effective radius and thermal power increase first and then decrease.The injected volume and temperature significantly affect,with higher injection temperatures slowing thermal recovery,and the thermal regulation efficiency is more sensitive to changes in formation permeability and thermal conductivity.The heat extraction performance is positively correlated with all factors.The levelized cost of electricity is estimated at 0.1203$/(kW·h)during the cold storage.During the heat recovery,annual profit is primarily driven by cooling benefits.
文摘In 1993,the World Bank released a global report on the efficacy of health promotion,introducing the disability-adjusted life years(DALY)as a novel indicator.The DALY,a composite metric incorporating temporal and qualitative data,is grounded in preferences regarding disability status.This review delineates the algorithm used to calculate the value of the proposed DALY synthetic indicator and elucidates key methodological challenges associated with its application.In contrast to the quality-adjusted life years approach,derived from multi-attribute utility theory,the DALY stands as an independent synthetic indicator that adopts the assumptions of the Time Trade Off utility technique to define Disability Weights.Claiming to rely on no mathematical or economic theory,DALY users appear to have exempted themselves from verifying whether this indicator meets the classical properties required of all indicators,notably content validity,reliability,specificity,and sensitivity.The DALY concept emerged primarily to facilitate comparisons of the health impacts of various diseases globally within the framework of the Global Burden of Disease initiative,leading to numerous publications in international literature.Despite widespread adoption,the DALY synthetic indicator has prompted significant methodological concerns since its inception,manifesting in inconsistent and non-reproducible results.Given the substantial diffusion of the DALY indicator and its critical role in health impact assessments,a reassessment is warranted.This reconsideration is imperative for enhancing the robustness and reliability of public health decisionmaking processes.
文摘中国语际翻译的历史最早可以追溯到西汉时期,但当时翻译的主要内容都是佛经,直到清朝才出现了第一首被译成中文的英语诗歌——A Psalm of Life。而清朝至今,这首诗已有多个译本。在20世纪70年代,德国学者凯瑟琳娜·赖斯在其著作《翻译批评——潜力与制约》中,提出了以文本类型为导向,结合语言内因素(语言范畴)、语言外因素(语用范畴)和功能因素(功能范畴)的翻译批评模式。因此,基于赖斯的翻译批评模式,文章从文本类型、语言范畴、语用范畴和功能范畴四方面对黄新渠、黄杲炘和黄一宁三人的译本进行对比赏析。通过分析发现,三人的译本基本都再现了原文的内容和风格,句式、节奏上也基本与原文保持一致;而在语义、词汇、语法和文体上,每一译本都有其各自的优点。此外,译本的语用和功能因素也显著影响了翻译策略的选择。
文摘High-rise housing is being built in increasingly densely populated urban residential areas in Tokyo,Japan.On the other hand,detached houses are built on small,subdivided sites.In urban residential areas where detached houses are lined up,many elements related to daily life are located near roadside space and spill out onto the road.This is a distinctive modern urban residential landscape.The purpose of this study is to get closer to the reality of urban residential life.For that,we will consider the characteristics and roles of elements related to daily life that can be observed in many areas around roadside space in an urban residential area lined with detached houses,in urban living environments.This study focuses on the detached residential area of Bunkyo Ward.A field survey will be conducted to investigate the amount of elements related to daily life that can be observed from the road.In addition,we will conduct a questionnaire survey of residents in the survey area regarding their use of and awareness of the roadside space.Finally,we will investigate the relationship between lifestyle factors and urban residential life from both quantitative and qualitative perspectives.
文摘In this paper Cheng Yanqiu’s personality,manliness and his hobbies are discussed.From the narration of his farming life in the 1940s and his founding of schools his view on life is to be seen.In the latter part of the paper the artistic achievements of his masterpiece“The Lucky Purse”are explored.
基金funded by the National Natural Science Foundation of China(Nos.12202030,12472208)the National Science and Technology Major Project,China(No.J2019-IV-0012-0080)+3 种基金the Foundation of State Key Laboratory of Structural Analysis,Optimization and CAE Software for Industrial Equipment,China(No.GZ24122)the Foundation of the Opening Project of State Key Laboratory of Advanced Ceramics,China(No.SKL202408SIC)the Foundation of the State Key Laboratory for Strength and Vibration of Mechanical Structures,China(No.SV2024-KF-14)We also thank the equipment support from the Analysis&Testing Center in Beihang University.
文摘Engineering systems such as aero-engines have the characteristics of complex structural geometries,diverse material types and variable load spectra,which pose great challenges for predicting the service life of practical engineering structures.In this regard,a novel stress fatigue life prediction model applicable to the whole life stage and complex stress states has been developed.The novel model and the widely used total strain life prediction model were used to predict the fatigue life of specimens with various alloys(TC4.TC17,FGH95,GH907.DZ125 and GH4169)and notch geometries(K_(t)=1 and K_(t)=3)as well as stress ratios(R=-1,R=0.1 and R=0.5).The results show that the novel model is applicable to the whole life stage with satisfactory life prediction accuracy,thus having greater potential in engineering applications.Furthermore,the novel model was also applied to predict the fatigue life of the bridge-type pad and plate specimen contact component within±2 dispersion band.
基金supported by the Turkish Green Crescent Society under Grant[41402653-160-6/333].
文摘Background The effectiveness of life skills-based prevention programs to prevent substance addiction has been underexplored in Türkiye,likely in part due to the lack of validated measurement tools developed specifically for that purpose.Therefore,the aim of this study is to develop a tool to measure life skills for middle school students.The present study aims to test the factorial structure,reliability,convergent and discriminant validity,and measurement invariance across gender and age groups of the Green Crescent Life Skills(GCLS)Scale.Methods The study was conducted in Istanbul with two different sample groups.The first sample consisted of 566 and the second sample consisted of 885 middle school students.In the study,exploratory factor analysis(EFA)was applied to the first sample,and confirmatory factor analysis(CFA)was applied to the second sample to test the factorial structure of the scale.Convergent and discriminant validity were examined to provide evidence for construct-based validity.The reliability of the scale was assessed with Cronbach’sα,composite reliability,McDonald’sω,and test-retest.Results The EFA results showed that the scale consisted of four factors(self-awareness,coping with negative emotions,thinking skills,and peer relations).CFA results also confirmed this structure.The results revealed a significant positive correlation(r=0.52,p<0.01)between life skills and avoidance self-efficacy scores,as well as a significant negative correlation(r=−0.53,p<0.01)between life skills and attitude toward drug use scores.Additionally,it was found that measurement invariances based on gender and age groups were provided.It was determined that all sub-dimensions had sufficient reliability levels.Conclusion The findings of this validation study show that the GCLS Scale,which assesses four skills in a self-reported format,is a valid and reliable scale with considerable potential utility in monitoring life skills in Turkish adolescent populations.
文摘The article contains a list of 14 structured technical sheets on roots, rhizomes or tubers that will serve as guidance in improving the quality of health of people. The used method was through an active search for literature that brought the observed aspects to the structuring of the technical sheets, i.e., literature that contains data related to composition, active ingredients, interaction (when described in the consulted literature), health condition in which they may be useful in helath care by various health professionals and anyone who may be of interest. The data obtained shows that there is a need for a careful evaluation of the foods (that contain roots, rhizomes, or tubers) used by polymedicated people due to possible interactions and incompatibilities that may exist.
文摘BACKGROUND Insomnia is a common sleep disorder that negatively impacts quality of life and is frequently comorbid with depression and anxiety.Chronic insomnia affects approximately 15%of the global population,with higher prevalence among females and the elderly.While existing research suggests a bidirectional relationship between insomnia and emotional disorders,the specific impact of insomnia severity on depression,anxiety,and quality of life remains unclear.This study investigates the correlation between insomnia severity and these factors in psychiatric outpatients,hypothesizing that greater insomnia severity is associated with higher levels of depression and anxiety,as well as poorer quality of life.AIM To explore the correlation between insomnia severity and depression,anxiety,and quality of life in primary chronic insomnia patients.METHODS From June to December 2023,345 patients with primary insomnia in Chifeng city were recruited and divided into three groups based on Pittsburgh sleep quality index(PSQI)scores:Mild(n=137),moderate(n=162),and severe(n=46).Demographic data were collected via questionnaires.Self-rating depression scale(SDS),self-rating anxiety scale(SAS),PSQI,and short form 36(SF-36)scores were compared,and Pearson and partial correlation analyses were performed.RESULTS The greater the degree of insomnia,the greater the symptoms of depression and anxiety(P<0.001).The more severe the insomnia,the lower the SF-36 score(excluding body pain),and the difference between the three groups was statist ically significant(P<0.001).Pearson correlation analysis and partial correlation analysis depicted the SDS score and SAS score were apparently positively correlated with the severity of insomnia(P<0.001).Pearson correlation analysis and partial correlation analysis depicted the SF-36 scores were apparently positively correlated with the severity of insomnia(P<0.05).CONCLUSION Depression and anxiety are independent factors influencing insomnia severity in primary chronic insomnia patients.Higher depression/anxiety levels correlate with worse insomnia,impacting quality of life.
基金supported by the National Key Research and Development Program of China(Grant No.2021YFC2800600)the National Natural Science Foundation of China(Grant No.52071203).
文摘Polymethyl methacrylate(PMMA)has the advantages of good transparency,corrosion resistance and light weight and can be used as the preferred material for pressure-resistant cabins of fully transparent submersibles.In this study,based on the fracture mechanics method,a calculation method for estimating the residual fatigue life of a PMMA manned cabin is proposed by improving the small-time scale fatigue crack growth rate model.This improved model is verified by the experimental data of the PMMA material.Then,through the Weibull and Gumbel combined distribution functions,the fatigue load spectrum suitable for the fully transparent manned cabin is fitted according to the dive data.A parametric analysis of the residual fatigue life of the fully transparent manned cabin under various initial crack sizes and dwell time is conducted,yielding valuable results.This study aims to increase the safety of fully transparent pressure-resistant cabins and offer insights for fatigue analysis of underwater structures utilizing PMMA materials.
基金supported by This work was supported by the Ministry of Science and Technology of the People’s Republic of China(STI2030-Major Projects2021ZD0201900)。
文摘Objective This study examines the sequential mediating roles of body pain and self-reported health in the association between sleep duration and self-reported life satisfaction among elderly Chinese adults.Methods Data from the fifth wave of the China Health and Retirement Longitudinal Survey(CHARLS)were used to analyse the relationships between sleep duration and body pain,self-reported health,and life satisfaction through logistic regression and Restricted Cubic Spline(RCS)analyses.The sequential mediation effects of body pain and self-reported health status were examined via chain mediation analysis.Results Logistic regression analysis showed that sleeping fewer than 6 hours or 6-7 hours was linked to higher risks of body pain,poor health,and dissatisfaction with life compared to sleeping 7-8 hours(all P<0.05).Additionally,those sleeping more than 9 hours also had increased risks of poor health and dissatisfaction with life compared to those sleeping 7-8 hours(all P<0.05).Chain mediation analysis showed that body pain and self-reported health status sequentially mediated 46.15%of the association between sleep duration and life satisfaction.Conclusion Body pain and self-reported health may shape the relationship between sleep duration and life satisfaction in elderly Chinese adults.
文摘Objective:This study aimed to summarize the quality of life experiences of individuals with physical frailty undergoing hemodialysis or peritoneal dialysis and to identify the difficultiesand resources that enable better person-centered health care.Methods:The study described is a qualitative meta-synthesis literature review.The search was performed in databases such as CINAHL,Scopus,PubMed,Web of Science,the Cochrane Library,and Cuiden Plus through Medical Subject Headings and free terms.Qualitative and mixed studies were included on individuals undergoing hemodialysis or peritoneal dialysis,18 years of age or older,published in English or Spanish,between January 2013 and January 2024.The Mixed Methods Appraisal Tool was used to assess the methodological quality.The information was analyzed and coded through a socioecological model and the social determinants of health.Results:Fourteen qualitative and two mixed articles were selected.A total of 256 individuals participated in the study.Seventeen themes and 25 sub-themes were identifiedand grouped into two blocks(difficulties and resources).The difficultiesthat stood out were a low tolerance for activities of daily living and physical activity,loss of self-control over life and social roles,and lack of community and public resources.As for the resources,the following was found:the positive meaning of dialysis,the safety offered by close individuals and the healthcare team,the activation of specificprograms,and person-centered policies.Conclusions:The analysis and interpretation of the identifieddifficultiesand resources revealed key elements to consider when designing and implementing health programs for individuals undergoing dialysis.Future research should explore these dimensions in diverse cultural and geographical contexts to enhance generalizability and support health equity.
文摘Food breakdown during storage and transit greatly adds to worldwide food waste.Biodegradable edible coatings derived from natural sources provide a sustainable method to extend the shelf life and preserve the freshness of fresh fruit.This study explores the potential of the readily available and nutrient-rich seaweed,Caulerpa lentillifera,as a base material for edible coatings that can enhance the shelf life and maintain the physicochemical properties of fruits and vegetables.Caulerpa lentillifera,a marine macroalga renowned for its unique biochemical composition,presents a promising avenue for developing sustainable bio-coatings to improve the post-harvest quality of fresh produce.Biodegradable edible coatings derived from natural sources provide a sustainable method to extend the shelf life and preserve the freshness of fresh fruit.This study is aimed at exploring the potential of Caulerpa lentillifera,a nutrient-dense green seaweed,as a foundational material for creating edible coatings to enhance the post-harvest quality of fruits and vegetables.Various Caulerpa lentillifera-derived coating formulations were developed and applied to specific fruits and vegetables.The coated samples were maintained under controlled conditions and assessed for alterations in physicochemical parameters,including weight loss,hardness,colour,and microbial proliferation.The optimised coating formulation markedly diminished weight loss,postponed ripening,and maintained firmness and colour relative to uncoated controls.The coating demonstrated promising antibacterial properties,aiding in the extension of shelf life.Coatings derived from Caulerpa lentillifera offer a viable,environmentally sustainable alternative to synthetic preservatives,facilitating the advancement of sustainable food preservation technology.
文摘This paper critically re-examines the anthropocentric“Goldilocks Zone”paradigm that has dominated the search for extraterrestrial life.As of 2024,more than 5,500 exoplanets have been identified,yet only about 2%are located within the traditionally defined habitable zone(National Aeronautics and Space Administration(NASA)Exoplanet Archive,2024;Kane et al.,2023).Moreover,the discovery of extremophiles-organisms thriving in high-radiation,extreme heat,or vacuum environments-demonstrates that the boundaries of life far exceed Earth-like conditions(Rothschild&Mancinelli,2001).
基金Supported by The Science Foundation of 925th Hospital,No.2023[3]and No.2022[3/4]The Guizhou Provincial Health Commission Science and Technology Fund,No.gzwkj2023-135。
文摘BACKGROUND Cardiovascular health(CVH)plays a crucial role in overall health,but its association with metabolic-associated fatty liver disease(MAFLD)remains unclear.AIM To investigate the relationship between CVH,measured using Life’s Essential 8(LE8)and Life’s Simple 7(LS7),and the prevalence of MAFLD.METHODS This cross-sectional study had a sample of 2234 individuals,representing approximately 120 million individuals in the United States.Baseline parameters were compared between the LE8 and LS7 groups.Logistic regression models were used to evaluate the relationship between LE8,LS7,and MAFLD,while taking into account confounding factors.The investigation employed restricted cubic splines to investigate non-linear associations.Subgroup analyses and sensitivity studies were performed to evaluate the strength and reliability of the results.RESULTS Higher LE8 and LS7 scores were significantly associated with a decreased risk of MAFLD,even after controlling for demographic,socioeconomic,and clinical variables.This association demonstrated a non-linear pattern,with the most dramatic risk reduction observed at higher CVH levels.Individual CVH components,notably healthy behaviors and factors,exhibited strong relationships with MAFLD.Subgroup analyses indicated consistent relationships across several demographics.Sensitivity tests utilizing other MAFLD definitions validated the robustness of the findings.CONCLUSION Higher adherence to CVH criteria,as indicated by LE8 and LS7 scores,is associated with a significantly lower risk of MAFLD.These results emphasize the need to advance CVH to control and avoid MAFLD.
文摘This study examined the mediating role of job satisfaction in explaining the relationship between work-family conflict and life satisfaction among Turkish academicians.Employing a cross-sectional study design 645 academicians aged between 24 and 65(male=45.1%,female=54.9%;professors=12.1%,associate professors=17.7%,assistant professors=28.2%,lecturers=17.8%,research assistants=24.2%;mean age and SD=39.72±8.94)completed the Job Satisfaction Scale,Life Satisfaction Scale,and the Work-Family Conflict Scale.They also self-reported their demographics.The findings from PROCESS MACRO analysis indicated work-family conflict to predict lower job satisfaction among academicians.Those with higher job satisfaction were also self-reported with higher life satisfaction.Lob satisfaction mediated the relationship between the academician’s work family conflict and life satisfaction for higher life satisfaction.The findings of this study indicate a need to implement work-family and life satisfaction measures to enhance job satisfaction among academics.
