Background:In 2021,the American College of Medical Genetics and Genomics(ACMG)recommended reporting actionable genotypes in 73 genes associated with diseases for which preventive or therapeutic measures are available....Background:In 2021,the American College of Medical Genetics and Genomics(ACMG)recommended reporting actionable genotypes in 73 genes associated with diseases for which preventive or therapeutic measures are available.Evaluations of the association of actionable genotypes in these genes with life span are currently lacking.Methods:We assessed the prevalence of coding and splice variants in genes on the ACMG Secondary Findings,version 3.0(ACMG SF v3.0),list in the genomes of 57,933 Icelanders.We assigned pathogenicity to all reviewed variants using reported evidence in the ClinVar database,the frequency of variants,and their associations with disease to create a manually curated set of actionable genotypes(variants).We assessed the relationship between these genotypes and life span and further examined the specific causes of death among carriers.展开更多
In this paper,a class of semilinear parabolic equations with cross coupling of power and exponential functions and large initial values are studied.By constructing and solving ordinary differential equations,the upper...In this paper,a class of semilinear parabolic equations with cross coupling of power and exponential functions and large initial values are studied.By constructing and solving ordinary differential equations,the upper and lower bounds on the solution life span of the equations areobtained.展开更多
The ef fects of salinity on the copepod, A cartia tonsa in terms of daily egg production rate(EPR), hatching success, fecal pellet production rate(FPR), naupliar development time and survival, sex ratio, and total lif...The ef fects of salinity on the copepod, A cartia tonsa in terms of daily egg production rate(EPR), hatching success, fecal pellet production rate(FPR), naupliar development time and survival, sex ratio, and total life span were determined in laboratory conditions through three experiments. In experiment 1, EPR, hatching success, and FPR of individual females were monitored at salinities of 13, 20, 35 and 45 during short-periods(seven consecutive days). Results show EPR was aff ected by salinity with the highest outputs recorded at 20 and 35, respectively, which were considerably higher than those at 13 and 45. Mean FPR was also higher in 35 and 20. In experiment 2, the same parameters were evaluated over total life span of females(long-term study). The best EPR and FPR were observed in 35, which was statistically higher than at 13 and 20. In experiment 3, survival rates of early nauplii until adult stage were lowest at a salinity of 13. The development time increased with increasing of salinity. Female percentage clearly decreased with increasing salinity. Higher female percentages(56.7% and 52.2%, respectively) were signifi cantly observed at two salinities of 13 and 20 compared to that at 35(25%). Total longevity of females was not af fected by salinity increment. Based on our results, for mass culture we recommend that a salinity of 35 be adopted due to higher reproductive performances, better feeding, and faster development of A. tonsa.展开更多
The paper deals with heat equations coupled via exponential nonlinearities. We are interested in the life span （or blow-up time） and obtain the maximal existence time of blow-up solutions. Our proof is based on the ...The paper deals with heat equations coupled via exponential nonlinearities. We are interested in the life span （or blow-up time） and obtain the maximal existence time of blow-up solutions. Our proof is based on the comparison principle and Kaplan＇s method.展开更多
This paper deals with the Cauchy problem for a doubly singular parabolic equation with a weighted source ut=div｜u｜p-2um）＋｜x｜α uq ,（x,t）∈RN×（0,t）,where N ≥ 1, 1 〈 p 〈 2, m 〉 max（0,3 -p/N} satisfyi...This paper deals with the Cauchy problem for a doubly singular parabolic equation with a weighted source ut=div｜u｜p-2um）＋｜x｜α uq ,（x,t）∈RN×（0,t）,where N ≥ 1, 1 〈 p 〈 2, m 〉 max（0,3 -p/N} satisfying 2 〈 p＋m 〈 3, q 〉 1, and（α 〉 N（3 - p - m） - p. We give the secondary critical exponent on the decay asymptotic behavior of an initial value at infinity for the existence and non-existence of global solutions of the Cauchy problem. Moreover, the life span of solutions is also studied.展开更多
In this paper the authors consider Cauchy problem of first order quasilinear hyperbolic and prove that existence of its periodic solutions and estimates of life span of solutions. This results reveals the relationship...In this paper the authors consider Cauchy problem of first order quasilinear hyperbolic and prove that existence of its periodic solutions and estimates of life span of solutions. This results reveals the relationship of dissipation and smoothness of periodic solutions.展开更多
Considering the insulators ageing in a mixture of PVC and dye, set following operating conditions and time to ensure proper operation and perfect safety of industrial installations using insulated conductors. The resu...Considering the insulators ageing in a mixture of PVC and dye, set following operating conditions and time to ensure proper operation and perfect safety of industrial installations using insulated conductors. The results showed that the insulation carried out by the L.C main office was a good quality (on thermal aspect), because the resistance of the insulation is so high (i.e. 3940 Mega Ohms under normal conditions). The results showed a lifespan of 50 years at a temperature of 40°C (close to ambient temperature), plus minus 33 years at a temperature of 70°C;plus minus 22 years at a temperature of 100°C and 12 years at a temperature of 160°C. Furthermore, information on chemical attack, the results showed that PVC cables have poor resistance to sulfuric acid attack (having a pH of 1.5 and a density of 1.84 g/cm<sup>3</sup>). LC/Gecamines is able to produce locally a good quality of electrical cables.展开更多
Drosophila melanogaster mutants with deficient kynurenine (KYN) formation from tryptophan (TRP) have longer life span than wild type flies. Administration of alpha-methyl-TRP and 5-methyl-TRY, the inhibitors of TRP-KY...Drosophila melanogaster mutants with deficient kynurenine (KYN) formation from tryptophan (TRP) have longer life span than wild type flies. Administration of alpha-methyl-TRP and 5-methyl-TRY, the inhibitors of TRP-KYN metabolism, prolonged life span in wild-type flies. Both inhibitors are not available for human use. Berberine, an isoquinoline alkaloid isolated from berberis aristata is known as the herb widely used in traditional Chinese and Indian medicine. Berberin is a strong inhibitor of the enzyme catalyzing TRP conversion into KYN. Considering this particular feature we investigated the effect of berberine on life-and health-span in wild-type Drosophila melanogaster. The results of our study showed that Berberine extended mean, median and maximum life span of female flies. Berberine did not affect the number of pupae of filial generation and decreased their lethality. Berberine increased locomotor activity (vertical climbing). The results of the study suggest that berberine prolongs life- and improves health-span of Drosophila melanogaster. Berberine might be a candidate drug for prevention and treatment of aging and aging-associated medical and psychiatric disorders.展开更多
Dietary γ-amino butyric acid (GABA) has been suggested to decrease systolic blood pressure. This study aimed to ex-amine the effects of dietary GABA on the life span of stroke-prone spontaneously hypertensive rats (S...Dietary γ-amino butyric acid (GABA) has been suggested to decrease systolic blood pressure. This study aimed to ex-amine the effects of dietary GABA on the life span of stroke-prone spontaneously hypertensive rats (SHRSPs). In this study, life span was determined for SHRSPs provided 1% NaCl solution or 0.01% GABA in 1% NaCl solution as drinking water. The life span of the GABA-fed group (76.3 ± 1.65 days) was significantly shorter than that of the control group (81.6 ± 0.88 days). The results of this study may not be applicable to humans. Future studies will be necessary to elucidate the mechanism underlying this phenomenon.展开更多
The paper considers the Cauchy problem with small initial values for semilinear wave equations with weighted nonlinear terms.Similar to Strauss exponent p0(n)which is the positive root of the quadratic equation 1+1/2(...The paper considers the Cauchy problem with small initial values for semilinear wave equations with weighted nonlinear terms.Similar to Strauss exponent p0(n)which is the positive root of the quadratic equation 1+1/2(n+1)p-1/2(n-1)p^(2)=0,we get smaller critical exponents p_(m)(n),p_(m)^(*)(n)and have global existence in time when p>p_(m)(n)or p>p_(m)^(*)(n).In addition,for the blow-up case,the introduction of the spacial weight shows the optimality of new upper and lower bound.展开更多
Objective： To explore the effect and mechanism of ginsenoside Rg3 （Shenyi Capsule, 参一胶囊） on the postoperative life span of patients with non-small cell lung cancer （NSCLC）. Methods： The prospective, randomiz...Objective： To explore the effect and mechanism of ginsenoside Rg3 （Shenyi Capsule, 参一胶囊） on the postoperative life span of patients with non-small cell lung cancer （NSCLC）. Methods： The prospective, randomized, controlled method was adopted. One hundred and thirty- three patients with NSCLC were randomly assigned to 3 groups： Shenyi Capsule group （43 cases）, combined therapy group （Shenyi Capsule plus chemotherapy, 46 cases）, and chemotherapy group （44 cases）. The survival rates, immune function and the correlation between vascular endothelial growth factor （VEGF） expression and clinical effect were analyzed in the three groups. Results： （1） The 1-year survival rate in the Shenyi group, the combined group and the chemotherapy group was 76.7% （33/43）, 82.6% （38/46）, and 79.5% （35/44）, respectively; the 2-year survival rate was 67.4% （29/43）, 71.7% （33/46）, and 70.5% （31/44）, respectively; and the 3-year survival rate was 46.5% （20/43）, 54.3% （25/46）, and 47.7% （21/44）, respectively. There was no significant difference among the 3 groups （P〉0.05）. （2） NK cells were increased to different degrees and the ratio of CD4/CD8 was normal in the Shenyi Capsule group and the combined group, while the ratio of CD4/CD8 was disproportional in the chemotherapy group. （3） In the chemotherapy group, the 3-year survival rate was lower in patients with positive expression of VEGF than in patients with negative expression （37.0% vs 64.7%, χ^2=17.9, P〈0.01）, but no significant statistical difference was shown in the other two groups （53.6% vs 55.6%, P〉0.05; 44.4% vs 50.0%, P〉0.05）. Conclusion： Shenyi Capsule, especially in combination with chemotherapy, can improve the life span of patients with NSCLC after operation. The mechanism might be correlated with improving the immune function and anti-tumor angiogenesis.展开更多
Implications of the differences in leaf life span are still subject to debate in the field of ecophysiology.Since leaf traits associated with these differences may be decisive for determining the distribution of tree ...Implications of the differences in leaf life span are still subject to debate in the field of ecophysiology.Since leaf traits associated with these differences may be decisive for determining the distribution of tree species,this topic is particularly relevant in the context of climate change.This study analyzes the effects of the differences in leaf life span on premature losses of leaf area owing to insect herbivory and to abiotic stress.Loss of leaf area may be an important determinant of total leaf carbon assimilation.Seven Mediterranean tree species,distributed on four sites with different climates were studied.The species exhibited strong differences in leaf life span and in leaf traits,especially leaf mass per unit area.Premature leaf area losses were estimated in response to insect herbivory and summer drought over two years.The results revealed that,despite having older leaf cohorts with more damage,species with longer leaf duration had lower area lost to herbivores and less damage due to accelerated senescence during the summer drought.With respect to the predicted increase in water stress,deciduous species are at a disadvantage due to their high premature loss of leaf area and thus loss of photosynthetic capacity.展开更多
Objective: To explore the mechanism ofintegrated traditional Chinese and Westernmedicine (TCM--WM ) therapy on chronicaplastic anemia (CAA). Methods: The RBClife span of 30 normal human subjects and 30patients with CA...Objective: To explore the mechanism ofintegrated traditional Chinese and Westernmedicine (TCM--WM ) therapy on chronicaplastic anemia (CAA). Methods: The RBClife span of 30 normal human subjects and 30patients with CAA were measured by sir labelled technique before and after TCM--WMtherapy. The morphology and distribution ofRBC membrane protein granules were observed by freeze fracture etching and transmission electron microscope. Results: The halflife of erythrocytes (RBC TI/2)was shortenedin CAA cases and there was a significant difference compared to healthy control (P <0. 01). After therapy, the RBC life span prolonged and approached the normal level. Before treatment, there existed abnormal in morphology, decrease in amount and uneven indistribution of protein granules in protoplasmicface (PF) and extracellular face (EF) of RBCmembrane. After treatment, the protein granules of RBC membrane was improved and approached to control. Conclusions: The morphology, amount, quality and distribution ofRBC membrane protein granule were closelyrelated to its life span. The therapeutic effectof TCM--WM was better than that of WMalone and it had a function both in stabilizingmembrane protein and extending the RBC lifespan.展开更多
It is known that for 1【p【+∞, n=2 or 1【p【（n+2）/（n-2）, n≥3, the elliptic problemhas a unique solution （x） which is radially symmetric and satisfies ’（0）=0, ’（r）【0, （x）～Me<sup>-α|x|<sup>...It is known that for 1【p【+∞, n=2 or 1【p【（n+2）/（n-2）, n≥3, the elliptic problemhas a unique solution （x） which is radially symmetric and satisfies ’（0）=0, ’（r）【0, （x）～Me<sup>-α|x|<sup>2</sup></sup> as |x|→∞. Let u（x, t） be the solution （positive） ofIn Ref. [1| it has been proved that if λ】1, then u（x, t） blows up in finite time. We de-展开更多
The paper concerns Cauchy,problem for one-dimensional hydromagnetic dynamics with dissipative terms. When the dissipation coefficient is equal to zero it is shown that the smooth solutions develop shocks in the finite...The paper concerns Cauchy,problem for one-dimensional hydromagnetic dynamics with dissipative terms. When the dissipation coefficient is equal to zero it is shown that the smooth solutions develop shocks in the finite time if the initial amounts of entropy and magnetic field are smaller than those of sound waves; when it is larger than zero, and the initial amounts of entropyI this dissipation coefficient and the magnetic field in each period are smaller than those of sound Waves, then the smooth solutions blow up in the finite time. Moreover, the life-span of the smooth solution is given.展开更多
In this article, we investigate the lower bound of life-span of classical solutions of the hyperbolic geometry flow equations in several space dimensions with ＂small＂ initial data. We first present some estimates on...In this article, we investigate the lower bound of life-span of classical solutions of the hyperbolic geometry flow equations in several space dimensions with ＂small＂ initial data. We first present some estimates on solutions of linear wave equations in several space variables. Then, we derive a lower bound of the life-span of the classical solutions to the equations with ＂small＂ initial data.展开更多
Owing to the complex environmental conditions, suspension could induce complicated forces on submarine pipelines and even cause vortex-induced vibration, resulting in fatigue damage of pipelines. Through aiming at the...Owing to the complex environmental conditions, suspension could induce complicated forces on submarine pipelines and even cause vortex-induced vibration, resulting in fatigue damage of pipelines. Through aiming at the 28-inch submarine pipeline in the East China Sea, the pipeline was segmented according to the similarity, considering the factors of pipe assembly, typhoon, current, wave and seabed topography. The effects of span length on natural frequency in each section of submarine pipeline were analyzed by finite element model. The maximum safe span length allowed by each pipeline section was verified by fatigue cumulative damage theory, and the fatigue life of each pipeline section were predicted. The results showed that each order natural frequency of the pipeline decreased with the increase of span length. The calculated results of empirical formulas were much smaller than those of the FEM analysis. The increase of the gap between the suspended pipeline and the seabed was beneficial to enhance the fatigue life of the suspended pipeline.展开更多
In the current research,we investigated the impact of gradually increasing inbreeding on the life span and reproductive rate of yellow steppe lemmings,Eolagurus luteus,that reproduced in the Moscow Zoo.The focal capti...In the current research,we investigated the impact of gradually increasing inbreeding on the life span and reproductive rate of yellow steppe lemmings,Eolagurus luteus,that reproduced in the Moscow Zoo.The focal captive colony existed from 2017 to 2021.The studied animals belonged to the second to tenth generations.The founders of the colony were 5 females and 5 males originating from 3 females and 4 males livetrapped in the Zaisan basin(Kazakhstan).The degree of their descendant relatedness progressively increased.The animals intended to be used for reproduction were distributed to pairs with unfamiliar partners.We constructed the pedigree of 177 individuals and calculated their inbreeding coefficients.This parameter varied from O to 0.29,and the maximum values were registered in the lemmings of the seventh to tenth generations.We measured the life span of 61 individuals and used information about the reproduction or its absence in 45 pairs.A substantial decline in individual life span and reproductive parameters in the breeding pairs,along with a progressive increase in the inbreeding coefficients,was registered.The number of delivered litters,born pups,and young lived up to the age of puberty significantly depended on the level of mother inbreeding.The noticeable traits of inbreeding depression in the colony appeared in 2019-2020 when the offspring inbreeding coefficients reached approximately 0.2.Therefore,we assume that if the E.luteus population originates from a relatively small number of noninbred and unfamiliar individuals,then successful reproduction without significant inbreeding depression will continue for several generations of offspring.展开更多
The basement was located at the bottom of the building,which not only affected the quality of the whole construction project but also had special requirements for construction technology and construction requirements....The basement was located at the bottom of the building,which not only affected the quality of the whole construction project but also had special requirements for construction technology and construction requirements.In modern times,with the increasing height of the building,the pressure on the ground has grown,and the demands for basements in construction projects have also steadily increased.With the development of modern technology,various construction techniques for basements emerged within the construction industry.Thus,this paper analyses the type of basement floor construction technologies,highlighting the application of these methods,and points out critical issues to consider.By examining frequent basement leakage problems,the paper proposed several measures to improve the quality if basement construction,aiming to better protect the service life of the building and further improve overall quality,and offering valuable insights for future projects.展开更多
文摘Background:In 2021,the American College of Medical Genetics and Genomics(ACMG)recommended reporting actionable genotypes in 73 genes associated with diseases for which preventive or therapeutic measures are available.Evaluations of the association of actionable genotypes in these genes with life span are currently lacking.Methods:We assessed the prevalence of coding and splice variants in genes on the ACMG Secondary Findings,version 3.0(ACMG SF v3.0),list in the genomes of 57,933 Icelanders.We assigned pathogenicity to all reviewed variants using reported evidence in the ClinVar database,the frequency of variants,and their associations with disease to create a manually curated set of actionable genotypes(variants).We assessed the relationship between these genotypes and life span and further examined the specific causes of death among carriers.
基金Supported by Key Project Funding for Shaanxi Higher Education Teaching Reform Research (23BZ078)Shaanxi Provincial Education Science Planning Project (SGH24Y2782)+4 种基金Shaanxi Provincial Social Science Foundation Program(2024D008)Key Projects of the Second Huang Yanpei Vocational Education Thought Research Planning Project (ZJS2024ZN026)Shaanxi Higher Education Society Key Projects(XGHZ2301)2024 Annual Planning Project of the China Association for Non-Government Education (School Development Category)(CANFZG24095)the Youth Innovation Team of Shaanxi Universities。
文摘In this paper,a class of semilinear parabolic equations with cross coupling of power and exponential functions and large initial values are studied.By constructing and solving ordinary differential equations,the upper and lower bounds on the solution life span of the equations areobtained.
文摘The ef fects of salinity on the copepod, A cartia tonsa in terms of daily egg production rate(EPR), hatching success, fecal pellet production rate(FPR), naupliar development time and survival, sex ratio, and total life span were determined in laboratory conditions through three experiments. In experiment 1, EPR, hatching success, and FPR of individual females were monitored at salinities of 13, 20, 35 and 45 during short-periods(seven consecutive days). Results show EPR was aff ected by salinity with the highest outputs recorded at 20 and 35, respectively, which were considerably higher than those at 13 and 45. Mean FPR was also higher in 35 and 20. In experiment 2, the same parameters were evaluated over total life span of females(long-term study). The best EPR and FPR were observed in 35, which was statistically higher than at 13 and 20. In experiment 3, survival rates of early nauplii until adult stage were lowest at a salinity of 13. The development time increased with increasing of salinity. Female percentage clearly decreased with increasing salinity. Higher female percentages(56.7% and 52.2%, respectively) were signifi cantly observed at two salinities of 13 and 20 compared to that at 35(25%). Total longevity of females was not af fected by salinity increment. Based on our results, for mass culture we recommend that a salinity of 35 be adopted due to higher reproductive performances, better feeding, and faster development of A. tonsa.
基金Supported by the National Natural Science Foundation of China(Grant Nos.1117109211471164)+1 种基金the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.08KJB110005)A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘The paper deals with heat equations coupled via exponential nonlinearities. We are interested in the life span （or blow-up time） and obtain the maximal existence time of blow-up solutions. Our proof is based on the comparison principle and Kaplan＇s method.
基金partially supported by the Doctor Start-up Funding and Natural Science Foundation of Chongqing University of Posts and Telecommunications(A2014-25 and A2014-106)partially supported by Scientific and Technological Research Program of Chongqing Municipal Education Commission(KJ1500403)+3 种基金the Basic and Advanced Research Project of CQCSTC(cstc2015jcyj A00008)partially supported by NSFC(11371384),partially supported by NSFC(11426047)the Basic and Advanced Research Project of CQCSTC(cstc2014jcyj A00040)the Research Fund of Chongqing Technology and Business University(2014-56-11)
文摘This paper deals with the Cauchy problem for a doubly singular parabolic equation with a weighted source ut=div｜u｜p-2um）＋｜x｜α uq ,（x,t）∈RN×（0,t）,where N ≥ 1, 1 〈 p 〈 2, m 〉 max（0,3 -p/N} satisfying 2 〈 p＋m 〈 3, q 〉 1, and（α 〉 N（3 - p - m） - p. We give the secondary critical exponent on the decay asymptotic behavior of an initial value at infinity for the existence and non-existence of global solutions of the Cauchy problem. Moreover, the life span of solutions is also studied.
文摘In this paper the authors consider Cauchy problem of first order quasilinear hyperbolic and prove that existence of its periodic solutions and estimates of life span of solutions. This results reveals the relationship of dissipation and smoothness of periodic solutions.
文摘Considering the insulators ageing in a mixture of PVC and dye, set following operating conditions and time to ensure proper operation and perfect safety of industrial installations using insulated conductors. The results showed that the insulation carried out by the L.C main office was a good quality (on thermal aspect), because the resistance of the insulation is so high (i.e. 3940 Mega Ohms under normal conditions). The results showed a lifespan of 50 years at a temperature of 40°C (close to ambient temperature), plus minus 33 years at a temperature of 70°C;plus minus 22 years at a temperature of 100°C and 12 years at a temperature of 160°C. Furthermore, information on chemical attack, the results showed that PVC cables have poor resistance to sulfuric acid attack (having a pH of 1.5 and a density of 1.84 g/cm<sup>3</sup>). LC/Gecamines is able to produce locally a good quality of electrical cables.
文摘Drosophila melanogaster mutants with deficient kynurenine (KYN) formation from tryptophan (TRP) have longer life span than wild type flies. Administration of alpha-methyl-TRP and 5-methyl-TRY, the inhibitors of TRP-KYN metabolism, prolonged life span in wild-type flies. Both inhibitors are not available for human use. Berberine, an isoquinoline alkaloid isolated from berberis aristata is known as the herb widely used in traditional Chinese and Indian medicine. Berberin is a strong inhibitor of the enzyme catalyzing TRP conversion into KYN. Considering this particular feature we investigated the effect of berberine on life-and health-span in wild-type Drosophila melanogaster. The results of our study showed that Berberine extended mean, median and maximum life span of female flies. Berberine did not affect the number of pupae of filial generation and decreased their lethality. Berberine increased locomotor activity (vertical climbing). The results of the study suggest that berberine prolongs life- and improves health-span of Drosophila melanogaster. Berberine might be a candidate drug for prevention and treatment of aging and aging-associated medical and psychiatric disorders.
文摘Dietary γ-amino butyric acid (GABA) has been suggested to decrease systolic blood pressure. This study aimed to ex-amine the effects of dietary GABA on the life span of stroke-prone spontaneously hypertensive rats (SHRSPs). In this study, life span was determined for SHRSPs provided 1% NaCl solution or 0.01% GABA in 1% NaCl solution as drinking water. The life span of the GABA-fed group (76.3 ± 1.65 days) was significantly shorter than that of the control group (81.6 ± 0.88 days). The results of this study may not be applicable to humans. Future studies will be necessary to elucidate the mechanism underlying this phenomenon.
基金Supported by National Natural Science Foundation (Grant No.71572156)
文摘The paper considers the Cauchy problem with small initial values for semilinear wave equations with weighted nonlinear terms.Similar to Strauss exponent p0(n)which is the positive root of the quadratic equation 1+1/2(n+1)p-1/2(n-1)p^(2)=0,we get smaller critical exponents p_(m)(n),p_(m)^(*)(n)and have global existence in time when p>p_(m)(n)or p>p_(m)^(*)(n).In addition,for the blow-up case,the introduction of the spacial weight shows the optimality of new upper and lower bound.
文摘Objective： To explore the effect and mechanism of ginsenoside Rg3 （Shenyi Capsule, 参一胶囊） on the postoperative life span of patients with non-small cell lung cancer （NSCLC）. Methods： The prospective, randomized, controlled method was adopted. One hundred and thirty- three patients with NSCLC were randomly assigned to 3 groups： Shenyi Capsule group （43 cases）, combined therapy group （Shenyi Capsule plus chemotherapy, 46 cases）, and chemotherapy group （44 cases）. The survival rates, immune function and the correlation between vascular endothelial growth factor （VEGF） expression and clinical effect were analyzed in the three groups. Results： （1） The 1-year survival rate in the Shenyi group, the combined group and the chemotherapy group was 76.7% （33/43）, 82.6% （38/46）, and 79.5% （35/44）, respectively; the 2-year survival rate was 67.4% （29/43）, 71.7% （33/46）, and 70.5% （31/44）, respectively; and the 3-year survival rate was 46.5% （20/43）, 54.3% （25/46）, and 47.7% （21/44）, respectively. There was no significant difference among the 3 groups （P〉0.05）. （2） NK cells were increased to different degrees and the ratio of CD4/CD8 was normal in the Shenyi Capsule group and the combined group, while the ratio of CD4/CD8 was disproportional in the chemotherapy group. （3） In the chemotherapy group, the 3-year survival rate was lower in patients with positive expression of VEGF than in patients with negative expression （37.0% vs 64.7%, χ^2=17.9, P〈0.01）, but no significant statistical difference was shown in the other two groups （53.6% vs 55.6%, P〉0.05; 44.4% vs 50.0%, P〉0.05）. Conclusion： Shenyi Capsule, especially in combination with chemotherapy, can improve the life span of patients with NSCLC after operation. The mechanism might be correlated with improving the immune function and anti-tumor angiogenesis.
基金financial support from the Regional Government of Castilla-León(Project No.SA126G18)。
文摘Implications of the differences in leaf life span are still subject to debate in the field of ecophysiology.Since leaf traits associated with these differences may be decisive for determining the distribution of tree species,this topic is particularly relevant in the context of climate change.This study analyzes the effects of the differences in leaf life span on premature losses of leaf area owing to insect herbivory and to abiotic stress.Loss of leaf area may be an important determinant of total leaf carbon assimilation.Seven Mediterranean tree species,distributed on four sites with different climates were studied.The species exhibited strong differences in leaf life span and in leaf traits,especially leaf mass per unit area.Premature leaf area losses were estimated in response to insect herbivory and summer drought over two years.The results revealed that,despite having older leaf cohorts with more damage,species with longer leaf duration had lower area lost to herbivores and less damage due to accelerated senescence during the summer drought.With respect to the predicted increase in water stress,deciduous species are at a disadvantage due to their high premature loss of leaf area and thus loss of photosynthetic capacity.
文摘Objective: To explore the mechanism ofintegrated traditional Chinese and Westernmedicine (TCM--WM ) therapy on chronicaplastic anemia (CAA). Methods: The RBClife span of 30 normal human subjects and 30patients with CAA were measured by sir labelled technique before and after TCM--WMtherapy. The morphology and distribution ofRBC membrane protein granules were observed by freeze fracture etching and transmission electron microscope. Results: The halflife of erythrocytes (RBC TI/2)was shortenedin CAA cases and there was a significant difference compared to healthy control (P <0. 01). After therapy, the RBC life span prolonged and approached the normal level. Before treatment, there existed abnormal in morphology, decrease in amount and uneven indistribution of protein granules in protoplasmicface (PF) and extracellular face (EF) of RBCmembrane. After treatment, the protein granules of RBC membrane was improved and approached to control. Conclusions: The morphology, amount, quality and distribution ofRBC membrane protein granule were closelyrelated to its life span. The therapeutic effectof TCM--WM was better than that of WMalone and it had a function both in stabilizingmembrane protein and extending the RBC lifespan.
基金Project supported by the National Natural Science Foundation of China.
文摘It is known that for 1【p【+∞, n=2 or 1【p【（n+2）/（n-2）, n≥3, the elliptic problemhas a unique solution （x） which is radially symmetric and satisfies ’（0）=0, ’（r）【0, （x）～Me<sup>-α|x|<sup>2</sup></sup> as |x|→∞. Let u（x, t） be the solution （positive） ofIn Ref. [1| it has been proved that if λ】1, then u（x, t） blows up in finite time. We de-
基金Project supported by the National Natural Science Foundation of China(No. 10571024)the Natural Science Foundation of Henan Province of China (No.200510078005)the Science Foundation of Educational Department of Henan Province of China (No.200511051700)
文摘The paper concerns Cauchy,problem for one-dimensional hydromagnetic dynamics with dissipative terms. When the dissipation coefficient is equal to zero it is shown that the smooth solutions develop shocks in the finite time if the initial amounts of entropy and magnetic field are smaller than those of sound waves; when it is larger than zero, and the initial amounts of entropyI this dissipation coefficient and the magnetic field in each period are smaller than those of sound Waves, then the smooth solutions blow up in the finite time. Moreover, the life-span of the smooth solution is given.
基金supported in part by the NNSF of China(11271323,91330105)the Zhejiang Provincial Natural Science Foundation of China(LZ13A010002)the Henan Provincial Natural Science Foundation of China(152300410226)
文摘In this article, we investigate the lower bound of life-span of classical solutions of the hyperbolic geometry flow equations in several space dimensions with ＂small＂ initial data. We first present some estimates on solutions of linear wave equations in several space variables. Then, we derive a lower bound of the life-span of the classical solutions to the equations with ＂small＂ initial data.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.11802168 and 51575331)project funded by China Postdoctoral Science Foundation(No.2019M661458)
文摘Owing to the complex environmental conditions, suspension could induce complicated forces on submarine pipelines and even cause vortex-induced vibration, resulting in fatigue damage of pipelines. Through aiming at the 28-inch submarine pipeline in the East China Sea, the pipeline was segmented according to the similarity, considering the factors of pipe assembly, typhoon, current, wave and seabed topography. The effects of span length on natural frequency in each section of submarine pipeline were analyzed by finite element model. The maximum safe span length allowed by each pipeline section was verified by fatigue cumulative damage theory, and the fatigue life of each pipeline section were predicted. The results showed that each order natural frequency of the pipeline decreased with the increase of span length. The calculated results of empirical formulas were much smaller than those of the FEM analysis. The increase of the gap between the suspended pipeline and the seabed was beneficial to enhance the fatigue life of the suspended pipeline.
基金carried out within the framework of the theme of a State Assignment of the Severtsov Institute of Ecology and Evolution,Russian Academy of Sciences,"Ecological and Evolutionary Aspects of Animal Behavior and Communication,"project no.AAAA-A18-118042690110-1.
文摘In the current research,we investigated the impact of gradually increasing inbreeding on the life span and reproductive rate of yellow steppe lemmings,Eolagurus luteus,that reproduced in the Moscow Zoo.The focal captive colony existed from 2017 to 2021.The studied animals belonged to the second to tenth generations.The founders of the colony were 5 females and 5 males originating from 3 females and 4 males livetrapped in the Zaisan basin(Kazakhstan).The degree of their descendant relatedness progressively increased.The animals intended to be used for reproduction were distributed to pairs with unfamiliar partners.We constructed the pedigree of 177 individuals and calculated their inbreeding coefficients.This parameter varied from O to 0.29,and the maximum values were registered in the lemmings of the seventh to tenth generations.We measured the life span of 61 individuals and used information about the reproduction or its absence in 45 pairs.A substantial decline in individual life span and reproductive parameters in the breeding pairs,along with a progressive increase in the inbreeding coefficients,was registered.The number of delivered litters,born pups,and young lived up to the age of puberty significantly depended on the level of mother inbreeding.The noticeable traits of inbreeding depression in the colony appeared in 2019-2020 when the offspring inbreeding coefficients reached approximately 0.2.Therefore,we assume that if the E.luteus population originates from a relatively small number of noninbred and unfamiliar individuals,then successful reproduction without significant inbreeding depression will continue for several generations of offspring.
文摘The basement was located at the bottom of the building,which not only affected the quality of the whole construction project but also had special requirements for construction technology and construction requirements.In modern times,with the increasing height of the building,the pressure on the ground has grown,and the demands for basements in construction projects have also steadily increased.With the development of modern technology,various construction techniques for basements emerged within the construction industry.Thus,this paper analyses the type of basement floor construction technologies,highlighting the application of these methods,and points out critical issues to consider.By examining frequent basement leakage problems,the paper proposed several measures to improve the quality if basement construction,aiming to better protect the service life of the building and further improve overall quality,and offering valuable insights for future projects.
