Objective: Urinary incontinence (UI) impacts all aspects of life activities. This study aims to characterize change in mobility within the community utilizing the Life Space Assessment (LSA) questionnaire in women und...Objective: Urinary incontinence (UI) impacts all aspects of life activities. This study aims to characterize change in mobility within the community utilizing the Life Space Assessment (LSA) questionnaire in women undergoing non-surgical UI treatment. Methods: This prospective cohort study, performed from July 2007 to March 2009, followed women seeking non-surgical UI treatment from an outpatient tertiary-care clinic and assessed their mobility and symptoms using LSA, Urogenital Distress Inventory (UDI-6), and Incontinence Impact Questionnaire (IIQ-7) at baseline and 2, 6, and 12 months post-treatment. Estimated Percent Improvement (EPI) and Patient Satisfaction Question (PSQ) were obtained post-treatment. The women were treated with multi-component behavioral and/or pharmacologic therapies, and we hypothesized that LSA would improve with treatment. Repeated measures analysis with Tukey’s HSD and backwards selection linear regression model were performed. Results: 70 ambulatory, community-dwelling women, aged 65 years or older, seeking non-surgical care for UI were recruited. LSA score decreased from baseline to 2 months (mean ± SD;63 ± 29 to 56 ± 28, p < 0.001) and was sustained at 6 and 12 months (54 ± 28, 54 ± 28). UDI scores improved from 36 ± 23 to 25 ± 24, p < 0.001, at 2 months, and improvement persisted at 6 and 12 months (22 ± 22, 21 ± 24). Improvements in UDI and patient perceived improvement in UI were not associated with LSA change. Age, race, and depression impacted LSA, which decreased 1-point for each additional year of age (p = 0.004), 6-points for each point higher on the Geriatric Depression Scale (GDS) (p = 0.002), and 6-point for African American race (p = 0.048). Conclusion: Decreased mobility represented by LSA was related to age, depression, and race, but not UI symptom improvement.展开更多
The remaining useful life(RUL) prediction of mechanical products has been widely studied for online system performance reliability, device remanufacturing, and product safety(safety awareness and safety improvement). ...The remaining useful life(RUL) prediction of mechanical products has been widely studied for online system performance reliability, device remanufacturing, and product safety(safety awareness and safety improvement). These studies incorporated many di erent models, algorithms, and techniques for modeling and assessment. In this paper, methods of RUL assessment are summarized and expounded upon using two major methods: physics model based and data driven based methods. The advantages and disadvantages of each of these methods are deliberated and compared as well. Due to the intricacy of failure mechanism in system, and di culty in physics degradation observation, RUL assessment based on observations of performance variables turns into a science in evaluating the degradation. A modeling method from control systems, the state space model(SSM), as a first order hidden Markov, is presented. In the context of non-linear and non-Gaussian systems, the SSM methodology is capable of performing remaining life assessment by using Bayesian estimation(sequential Monte Carlo). Being e ective for non-linear and non-Gaussian dynamics, the methodology can perform the assessment recursively online for applications in CBM(condition based maintenance), PHM(prognostics and health management), remanufacturing, and system performance reliability. Finally, the discussion raises concerns regarding online sensing data for SSM modeling and assessment of RUL.展开更多
With the human space exploration activities,space life science is an emerging interdisciplinary and it covers a wide range of research.Based on our country's manned space station and recoverable satellite science ...With the human space exploration activities,space life science is an emerging interdisciplinary and it covers a wide range of research.Based on our country's manned space station and recoverable satellite science experimental platform,the development of space life science research is very important to acquire new knowledge or new innovation in technology,to give further services to the human space exploration activities,to improve the national economic and social development.Based on present situation,both theoretical and applied researches were continuously performed in2015.Here,we review and summarize the researches on space life sciences which were contributed by Chinese scientists.展开更多
In the past two years,China’s space life science has made great progress.Space biomedical and life science programs have carried out ground-based research for the first batch of projects,and are preparing to carry ou...In the past two years,China’s space life science has made great progress.Space biomedical and life science programs have carried out ground-based research for the first batch of projects,and are preparing to carry out space-based experiments along with the construction of China’s space station.And space life science payload of the space station completed the development of positive samples.Thus,with the development of lunar exploration and Mars exploration projects,astrobiology research has also made a lot of basic achievements.On the basis of summarizing the development of space life science in China,this paper mainly introduces the important progress of payload technology and life science research.展开更多
With the further advancement of China’s major manned spaceflight project,the national space laboratory was successfully built.China has also made considerable progress and breakthroughs in the field of space life sci...With the further advancement of China’s major manned spaceflight project,the national space laboratory was successfully built.China has also made considerable progress and breakthroughs in the field of space life sciences.This paper reviews the related biological effects under space flight conditions,mainly including epigenetic effects,skeleton remodeling and peripheral body fluid circulation effects,as well as the research and application of space life science related biotechnology in the field of microbial culture and biological regeneration life support system.展开更多
With the human space exploration activities, space life science is an emerging interdiscipline,which covers a wide range of researches. Based on our country's manned space station and recoverable satellite science...With the human space exploration activities, space life science is an emerging interdiscipline,which covers a wide range of researches. Based on our country's manned space station and recoverable satellite science experimental platform, the development of space life science research is very important to acquire new knowledge or new technological innovation, to give further services to the human space exploration activities,to improve the national economic and social development. Both ground-based and flight applied studies were continuously performed in the previous 2 years. Here, we review and summarize the researches on space life sciences contributed by Chinese scientists.展开更多
In the past two years,space life sciences research in China is characterized by a tendency toward integration of scientific and engineering resources in preparing and implementing advanced space programs.In the field ...In the past two years,space life sciences research in China is characterized by a tendency toward integration of scientific and engineering resources in preparing and implementing advanced space programs.In the field of operational medicine,we carried out an international cooperated Head-Down Bed Rest(HDBR) experiment and investigated the effects of Chinese herbs compounds on astronaut's physiological functions.The effect of microgravity and its mechanisms were further studied from the level of physiology and biology.At the same time,state-level platform for ground and space experiment was established.展开更多
In the past two years, space life science research in China is characterized by a wide area of basic researches for providing foundation for the future China Space Station. The effect of microgravity and radiation was...In the past two years, space life science research in China is characterized by a wide area of basic researches for providing foundation for the future China Space Station. The effect of microgravity and radiation was further studied from physiology phenomena to the level of bio-molecule mechanisms. Chinese space life science is maturing in a new era of comprehensive development.Here, we review and summarize researches on space life sciences which were contributed by Chinese scientists.展开更多
Manned spacecraft pose challenges in terms of extremely high safety and reliability, and with the growth of system complexity and longer on-orbit operation time, the traditional management mode, such as monitoring the...Manned spacecraft pose challenges in terms of extremely high safety and reliability, and with the growth of system complexity and longer on-orbit operation time, the traditional management mode, such as monitoring the threshold of parameter passively, is difficult to meet the required safety standards. Predictive maintenance, which analyzes the system heath trend and estimates remaining useful life(RUL) to establish maintenance strategies ahead of time before failure occurs, is a new mode to approach maintenance tasks. Here, a predictive maintenance strategy for complex manned spacecraft is proposed based on the remaining useful life estimation technique. Firstly, a health index is established based on an abundance of telemetry data, reflecting the system's current health state. Secondly, we map the health index to the remaining useful life through system degradation modelling, taking into consideration both the system's stochastic deterioration and uncertainty. The maintenance and management strategies are then made based on the calculated distribution of RUL time. Finally, a case study on Chinese space station energy system predictive maintenance is presented.展开更多
The key to failure prevention for aero-engine lies in performance prediction and the exhaust gas temperature margin(EGTM)is used as the most important degradation parameter to obtain the operating performance of the a...The key to failure prevention for aero-engine lies in performance prediction and the exhaust gas temperature margin(EGTM)is used as the most important degradation parameter to obtain the operating performance of the aero-engine.Because of the complex environment interference,EGTM always has strong randomness,and the state space based degradation model can identify the noisy observation from the true degradation state,which is more close to the actual situations.Therefore,a state space model based on EGTM is established to describe the degradation path and predict the remaining useful life(RUL).As one of the most effective methods for both linear state estimation and parameter estimation,Kalman filter(KF)is applied.Firstly,with EGTM degradation data,state space model approach is used to set up a state space model for aero-engine.Secondly,RUL of aero-engine is analyzed,and expected RUL and distribution of RUL are determined.Finally,the sate space model and KF algorithm are applied to an example of CFM-56aero-engine.The expected RUL is predicted,and corresponding probability density distribution(PDF)and cumulative distribution function(CDF)are given.The result indicates that the accuracy of RUL prediction reaches 7.76%ahead 580 flight cycles(FC),which is more accurate than linear regression,and therefore shows the validity and rationality of the proposed method.展开更多
文摘Objective: Urinary incontinence (UI) impacts all aspects of life activities. This study aims to characterize change in mobility within the community utilizing the Life Space Assessment (LSA) questionnaire in women undergoing non-surgical UI treatment. Methods: This prospective cohort study, performed from July 2007 to March 2009, followed women seeking non-surgical UI treatment from an outpatient tertiary-care clinic and assessed their mobility and symptoms using LSA, Urogenital Distress Inventory (UDI-6), and Incontinence Impact Questionnaire (IIQ-7) at baseline and 2, 6, and 12 months post-treatment. Estimated Percent Improvement (EPI) and Patient Satisfaction Question (PSQ) were obtained post-treatment. The women were treated with multi-component behavioral and/or pharmacologic therapies, and we hypothesized that LSA would improve with treatment. Repeated measures analysis with Tukey’s HSD and backwards selection linear regression model were performed. Results: 70 ambulatory, community-dwelling women, aged 65 years or older, seeking non-surgical care for UI were recruited. LSA score decreased from baseline to 2 months (mean ± SD;63 ± 29 to 56 ± 28, p < 0.001) and was sustained at 6 and 12 months (54 ± 28, 54 ± 28). UDI scores improved from 36 ± 23 to 25 ± 24, p < 0.001, at 2 months, and improvement persisted at 6 and 12 months (22 ± 22, 21 ± 24). Improvements in UDI and patient perceived improvement in UI were not associated with LSA change. Age, race, and depression impacted LSA, which decreased 1-point for each additional year of age (p = 0.004), 6-points for each point higher on the Geriatric Depression Scale (GDS) (p = 0.002), and 6-point for African American race (p = 0.048). Conclusion: Decreased mobility represented by LSA was related to age, depression, and race, but not UI symptom improvement.
基金Supported by Fundamental Research Funds for the Central Universities of China(Grant No.DUT17GF214)
文摘The remaining useful life(RUL) prediction of mechanical products has been widely studied for online system performance reliability, device remanufacturing, and product safety(safety awareness and safety improvement). These studies incorporated many di erent models, algorithms, and techniques for modeling and assessment. In this paper, methods of RUL assessment are summarized and expounded upon using two major methods: physics model based and data driven based methods. The advantages and disadvantages of each of these methods are deliberated and compared as well. Due to the intricacy of failure mechanism in system, and di culty in physics degradation observation, RUL assessment based on observations of performance variables turns into a science in evaluating the degradation. A modeling method from control systems, the state space model(SSM), as a first order hidden Markov, is presented. In the context of non-linear and non-Gaussian systems, the SSM methodology is capable of performing remaining life assessment by using Bayesian estimation(sequential Monte Carlo). Being e ective for non-linear and non-Gaussian dynamics, the methodology can perform the assessment recursively online for applications in CBM(condition based maintenance), PHM(prognostics and health management), remanufacturing, and system performance reliability. Finally, the discussion raises concerns regarding online sensing data for SSM modeling and assessment of RUL.
文摘With the human space exploration activities,space life science is an emerging interdisciplinary and it covers a wide range of research.Based on our country's manned space station and recoverable satellite science experimental platform,the development of space life science research is very important to acquire new knowledge or new innovation in technology,to give further services to the human space exploration activities,to improve the national economic and social development.Based on present situation,both theoretical and applied researches were continuously performed in2015.Here,we review and summarize the researches on space life sciences which were contributed by Chinese scientists.
基金Supported by Space Medical Experiment Project of China Manned Space Program(HYZHXM02003)。
文摘In the past two years,China’s space life science has made great progress.Space biomedical and life science programs have carried out ground-based research for the first batch of projects,and are preparing to carry out space-based experiments along with the construction of China’s space station.And space life science payload of the space station completed the development of positive samples.Thus,with the development of lunar exploration and Mars exploration projects,astrobiology research has also made a lot of basic achievements.On the basis of summarizing the development of space life science in China,this paper mainly introduces the important progress of payload technology and life science research.
文摘With the further advancement of China’s major manned spaceflight project,the national space laboratory was successfully built.China has also made considerable progress and breakthroughs in the field of space life sciences.This paper reviews the related biological effects under space flight conditions,mainly including epigenetic effects,skeleton remodeling and peripheral body fluid circulation effects,as well as the research and application of space life science related biotechnology in the field of microbial culture and biological regeneration life support system.
文摘With the human space exploration activities, space life science is an emerging interdiscipline,which covers a wide range of researches. Based on our country's manned space station and recoverable satellite science experimental platform, the development of space life science research is very important to acquire new knowledge or new technological innovation, to give further services to the human space exploration activities,to improve the national economic and social development. Both ground-based and flight applied studies were continuously performed in the previous 2 years. Here, we review and summarize the researches on space life sciences contributed by Chinese scientists.
文摘In the past two years,space life sciences research in China is characterized by a tendency toward integration of scientific and engineering resources in preparing and implementing advanced space programs.In the field of operational medicine,we carried out an international cooperated Head-Down Bed Rest(HDBR) experiment and investigated the effects of Chinese herbs compounds on astronaut's physiological functions.The effect of microgravity and its mechanisms were further studied from the level of physiology and biology.At the same time,state-level platform for ground and space experiment was established.
文摘In the past two years, space life science research in China is characterized by a wide area of basic researches for providing foundation for the future China Space Station. The effect of microgravity and radiation was further studied from physiology phenomena to the level of bio-molecule mechanisms. Chinese space life science is maturing in a new era of comprehensive development.Here, we review and summarize researches on space life sciences which were contributed by Chinese scientists.
文摘Manned spacecraft pose challenges in terms of extremely high safety and reliability, and with the growth of system complexity and longer on-orbit operation time, the traditional management mode, such as monitoring the threshold of parameter passively, is difficult to meet the required safety standards. Predictive maintenance, which analyzes the system heath trend and estimates remaining useful life(RUL) to establish maintenance strategies ahead of time before failure occurs, is a new mode to approach maintenance tasks. Here, a predictive maintenance strategy for complex manned spacecraft is proposed based on the remaining useful life estimation technique. Firstly, a health index is established based on an abundance of telemetry data, reflecting the system's current health state. Secondly, we map the health index to the remaining useful life through system degradation modelling, taking into consideration both the system's stochastic deterioration and uncertainty. The maintenance and management strategies are then made based on the calculated distribution of RUL time. Finally, a case study on Chinese space station energy system predictive maintenance is presented.
文摘The key to failure prevention for aero-engine lies in performance prediction and the exhaust gas temperature margin(EGTM)is used as the most important degradation parameter to obtain the operating performance of the aero-engine.Because of the complex environment interference,EGTM always has strong randomness,and the state space based degradation model can identify the noisy observation from the true degradation state,which is more close to the actual situations.Therefore,a state space model based on EGTM is established to describe the degradation path and predict the remaining useful life(RUL).As one of the most effective methods for both linear state estimation and parameter estimation,Kalman filter(KF)is applied.Firstly,with EGTM degradation data,state space model approach is used to set up a state space model for aero-engine.Secondly,RUL of aero-engine is analyzed,and expected RUL and distribution of RUL are determined.Finally,the sate space model and KF algorithm are applied to an example of CFM-56aero-engine.The expected RUL is predicted,and corresponding probability density distribution(PDF)and cumulative distribution function(CDF)are given.The result indicates that the accuracy of RUL prediction reaches 7.76%ahead 580 flight cycles(FC),which is more accurate than linear regression,and therefore shows the validity and rationality of the proposed method.
