Objective Telomere length is a key aging biomarker,but its sex-specific impact on individualized life expectancy remains uncertain.This study explores sex differences in leukocyte telomere length(LTL)and individualize...Objective Telomere length is a key aging biomarker,but its sex-specific impact on individualized life expectancy remains uncertain.This study explores sex differences in leukocyte telomere length(LTL)and individualized expected years of life lost(YLL).Methods A prospective cohort of 445,399 participants(203,731 males and 241,668 females)from the UK Biobank was analyzed.LTL values were log-transformed,and YLL was calculated using life tables.Multiple linear regression was applied to examine sex-specific associations.Results In males,each standard deviation(S.D.)increase in LTL was linked to a 0.965-year decrease in YLL(95%CI:–1.025,–0.900;P<0.001).In females,longer LTL was related to a 0.102-year increase in YLL(95%CI:0.057,0.146;P<0.001).Among postmenopausal females,LTL showed a protective effect similar to that in males(0.387-year decrease,95%CI:−0.446,–0.328;P<0.001),while premenopausal females exhibited a detrimental association(0.705-year increase,95%CI:0.625,0.785;P<0.001).Comparable trends were observed across major aging-related diseases,pointing to a consistent biological pattern.Conclusion The influence of LTL on life expectancy varies significantly by sex,with protective associations seen in males and postmenopausal females.This suggests hormonal involvement in telomere dynamics.The results support integrating sex-specific perspectives into aging and telomere research and clinical practice.展开更多
Introduction: Indicators of maternal health are often used to evaluate the social development and overall health of a population, as well as the accessibility of health services. Among these indicators, the Potential ...Introduction: Indicators of maternal health are often used to evaluate the social development and overall health of a population, as well as the accessibility of health services. Among these indicators, the Potential Years of Life Lost, which is associated with maternal deaths, is useful for the definition of priorities, monitoring, evaluation, and intervention, identifying the highest risk groups. Objective: To analyze the Potential Years of Life Lost by maternal death in Santa Catarina in 2000 and 2014. Method: An Ecological study with exploratory spatial analysis was conducted with data obtained from the Information System on Mortality and Live Births. Results: In the Information System, 35 maternal deaths in the year 2000 were identified and 24 in 2014. The total estimated years of life lost were 845 years in 2000 and 780 years in 2014, dominated by direct obstetric causes. In 2000, women who died lost, on average, 39.8 years of life;and 41.5 years in 2014. Conclusion: The spatial pattern observed in 2000 highlights areas of high risk in different regions of Santa Catarina. The greatest loss of years occurred in younger women, confirming the need to prevent and control maternal mortality and review strategies for compliance with public policies in the State.展开更多
The magnitude of the overall prevalence and racial disparity in induced abortion suggests that it is a major influence on the demographic and socioeconomic composition of the population of the United States (US). Howe...The magnitude of the overall prevalence and racial disparity in induced abortion suggests that it is a major influence on the demographic and socioeconomic composition of the population of the United States (US). However, the years of potential lives averted by induced abortion have not been systematically studied. We applied race-specific intra-uterine death estimates to the induced abortions occurring to non-Hispanic (NH) white and non-Hispanic (NH) black women in the US state of North Carolina in 2008. The resultant estimate of births averted by induced abortion was used to project years of potential life lost. All-cause detailed mortality data were used to compare induced abortion with other contributing causes of years of potential life lost before age 75 (YPLL 75). For NH whites, induced abortions in 2008 contributed 59% of total YPLL 75, and 1.5 times the total YPLL 75 from all other causes combined. For NH blacks, induced abortions in 2008 contributed 76% of total YPLL 75 and 3.2 times the total YPLL 75 from all other causes combined. Induced abortion is the overwhelmingly predominant contributing cause of preventable potential lives lost in the North Carolina population, and NH blacks are disproportionately affected.展开更多
Background:Colorectal cancer(CRC)is the fourth cause of cancer death in China.We aimed to provide national and subnational estimates and changes of CRC premature mortality burden during 2005–2020.Methods:Data from mu...Background:Colorectal cancer(CRC)is the fourth cause of cancer death in China.We aimed to provide national and subnational estimates and changes of CRC premature mortality burden during 2005–2020.Methods:Data from multi-source on the basis of the national surveillance mortality system were used to estimate mortality and years of life lost(YLL)of CRC in the Chinese population during 2005–2020.Estimates were generated and compared for 31 provincial-level administrative divisions in China.Results:Estimated CRC deaths increased from 111.41 thousand in 2005 to 178.02 thousand in 2020;age-standardized mortality rate decreased from 10.01 per 100,000 in 2005 to 9.68 per 100,000 in 2020.Substantial reduction in CRC premature mortality burden,as measured by age-standardized YLL rate,was observed with a reduction of 10.20%nationwide.Marked differences were observed in the geographical patterns of provincial units,and they appeared to be obvious in areas with higher economic development.Population aging was the dominant driver which contributed to the increase in CRC deaths,followed by population growth and age-specific mortality change.Conclusions:Substantial discrepancies were observed in the premature mortality burden of CRC across China.Targeted considerations were needed to promote a healthy lifestyle,expand cost-effective CRC early screening and diagnosis,and improve medical treatment to reduce CRC mortality among high-risk populations and regions with inadequate healthcare resources.展开更多
Purpose： Traffic injuries are among the leading causes of mortality and morbidity worldwide. Pedestrians have been considered as a high-risk group among road users, especially in middle- or low-income communities. Th...Purpose： Traffic injuries are among the leading causes of mortality and morbidity worldwide. Pedestrians have been considered as a high-risk group among road users, especially in middle- or low-income communities. This study attempted to determine the burden of pedestrians＇ fatalities in Fars, the southern province of Iran using years of life lost （YLL） approach. Methods： The data used in this study were retrieved from Fars Forensic Medicine Organization database on pedestrian traffic accidents. The YLL from 2009 to 2013 was estimated using the method presented by World Health organization. Some epidemiological characteristics of pedestrians＇ fatalities were analyzed by SPSS. Results： Although YLL among 1000 male pedestrians decreased from 2.5 in 2009 to 1.5 in 2013, it increased from 0.9 to 2.1 among 1000 females during the same period. Higher proportion of death was found in female, illiterate, and married pedestrians {p 〈 0.001 ）. In addition, mortality was higher in pedestrians living the cities, during daytime, at home, and in hospitals （p 〈 0.001 ）. Conclusion： Consistent with the global trends, burden of pedestrian accidents in Fats was also excep- tionally high. Considering the national and cultural aspects of different countries, improving the safety of pedestrians demands a multi-dimensional approach with interventional factors concerning policies, rules, pedestrians, motor vehicles and environmental conditions taken into consideration.展开更多
Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and q...Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics.展开更多
目的分析2012—2023年重庆市老年人自杀死亡率与死亡疾病负担变化趋势,为开展有针对性的干预提供建议。方法利用重庆市2012—2023年死因监测数据中根本死因为自杀(《国际疾病与相关健康问题统计分类第10版》编码:X60~X84、Y87)的60岁及...目的分析2012—2023年重庆市老年人自杀死亡率与死亡疾病负担变化趋势,为开展有针对性的干预提供建议。方法利用重庆市2012—2023年死因监测数据中根本死因为自杀(《国际疾病与相关健康问题统计分类第10版》编码:X60~X84、Y87)的60岁及以上老年人死亡个案,分析死亡率、标化死亡率、早死寿命损失年(years of life lost,YLL)率、平均寿命损失年(average years of life lost,AYLL)及不同死因构成比,比较不同性别和地区死亡率,率的趋势变化采用年度变化百分比(annual percent of change,APC)和平均年度变化百分比(average annual percent of change,AAPC)进行分析。结果2012—2023年60岁及以上老年人自杀死亡率与标化死亡率总体呈下降的趋势,分别以年均3.54%与4.02%下降,变化趋势均有统计学意义(P<0.05)。2012—2016年自杀死亡率以年均4.53%上升,2016—2021年以年均8.91%下降,变化趋势均有统计学意义(P<0.05)。仅2020年与2022年男性自杀死亡率高于女性(P<0.05)。2012—2023年男性自杀死亡率与标化死亡率分别以年均2.86%和3.44%下降,女性分别以年均4.21%和4.69%下降,变化趋势均有统计学意义(P<0.05)。农村地区老年人历年自杀死亡率均高于城市地区,差异均有统计学意义(P<0.05)。2012—2023年城市地区老年人自杀死亡率与标化死亡率均保持相对平稳的水平(P>0.05),而农村地区老年人自杀死亡率与标化死亡率分别以年均3.44%与4.02%下降(P<0.05)。60岁及以上老年人自杀导致的YLL率与AYLL分别由2012年的3.03‰与18.54年下降至2023年的2.26‰与17.50年,AAPC分别为-4.02%与-0.60%,变化趋势均有统计学意义(P<0.05)。比较历年不同自杀方式构成发现,杀虫剂中毒死亡占比呈下降的趋势,而悬吊死亡、从高处跳下、淹溺占比均呈上升的趋势(P<0.05)。结论重庆市60岁及以上老年人自杀死亡率较高,疾病负担较重,总体呈下降的趋势,应重视老年人自杀的早期识别与干预。展开更多
目的分析1992—2021年我国血吸虫病疾病负担变化趋势、预测2022—2030年我国血吸虫病疾病负担,为我国血吸虫病消除工作提供参考。方法从全球疾病负担研究(global burden of disease,GBD)数据库中获取1992—2021年我国、全球及不同社会...目的分析1992—2021年我国血吸虫病疾病负担变化趋势、预测2022—2030年我国血吸虫病疾病负担,为我国血吸虫病消除工作提供参考。方法从全球疾病负担研究(global burden of disease,GBD)数据库中获取1992—2021年我国、全球及不同社会人口学指数(socio-demographic index,SDI)地区人群血吸虫病患病率、年龄标化患病率、伤残调整寿命年(disability adjusted life year,DALYs)率、年龄标化DALYs率及归因于血吸虫感染的贫血伤残损失寿命年(years lost due to disability,YLDs)率、归因于血吸虫感染的贫血年龄标化YLDs率,计算各指标估计年度变化百分比(estimated annual percentage change,EAPC)及其95%可信区间(confidence Interval,CI)以分析疾病负担变化趋势。采用年龄-时期-队列(age-period-cohort,APC)模型分析1992—2021年我国人群血吸虫病患病率随年龄、时期和出生队列的变化趋势,采用贝叶斯年龄-时期-队列(Bayesian age-period-cohort,BAPC)模型预测2022—2030年我国血吸虫病疾病负担。结果2021年,我国人群血吸虫病年龄标化患病率为761.32/10万、年龄标化DALYs率为5.55/10万、归因于血吸虫感染的贫血年龄标化YLDs率为0.38/10万,均低于全球水平(分别为1914.30/10万、21.90/10万、3.36/10万)及中SDI地区(1413.61/10万、12.10/10万、1.93/10万)、低-中SDI地区(分别为2461.03/10万、26.81/10万、4.48/10万)和低SDI地区(分别为5832.77/10万、94.48/10万、10.65/10万),但高于高SDI地区(分别为59.47/10万、0.49/10万、0.05/10万)和高-中SDI地区(分别为123.11/10万、1.20/10万、0.12/10万)。2021年,我国男性人群血吸虫病患病率(820.79/10万)、DALYs率(5.86/10万)均高于女性人群(分别为697.96/10万、5.23/10万);女性人群归因于血吸虫感染的贫血YLDs率(0.66/10万)高于男性(0.12/10万);不同性别人群血吸虫病患病率高峰均为30~34岁组,男性、女性人群血吸虫病DALYs率高峰分别为15~19岁与20~24岁。与不同SDI地区人群比较,1992—2021年我国人群血吸虫病年龄标化患病率下降速度中等[EAPC=-1.51%,95%CI:(-1.65%,-1.38%)],年龄标化DALYs率[EAPC=-3.61%,95%CI:(-3.90%,-3.33%)]与归因于血吸虫感染的贫血年龄标化YLDs率[EAPC=-4.16%,95%CI:(-4.38%,-3.94%)]下降速度均最快。APC模型建模结果显示,1992—2021年我国人群血吸虫病患病率变化具有年龄、时期和队列效应,随年龄增长先上升后下降、随时期递进和出生队列推移均下降。BAPC模型预测显示,2022—2030年我国人群血吸虫病年龄标化患病率、年龄标化DALYs率和归因于血吸虫感染的贫血年龄标化YLDs率均呈下降趋势,2030年分别为722.72/10万[95%CI:(538.74/10万,906.68/10万)]、5.19/10万[95%CI:(3.54/10万,6.84/10万)]和0.30/10万[95%CI:(0.21/10万,0.39/10万)]。结论1992—2021年我国血吸虫病疾病负担呈下降趋势,预测2022—2030年我国血吸虫病疾病负担亦呈下降趋势。年龄、时期和队列均对人群血吸虫病患病率存在影响,需结合流行现状和防控需求精准开展消除血吸虫病工作。展开更多
目的分析2012—2023年重庆市老年人跌倒死亡率与疾病负担变化趋势,为开展有针对性地干预提供建议。方法利用2012—2023年死因监测数据中根本死因为跌倒(ICD-10:W00-W19)的死亡个案,采用SPSS 26.0统计软件分析死亡率、标化死亡率、早死...目的分析2012—2023年重庆市老年人跌倒死亡率与疾病负担变化趋势,为开展有针对性地干预提供建议。方法利用2012—2023年死因监测数据中根本死因为跌倒(ICD-10:W00-W19)的死亡个案,采用SPSS 26.0统计软件分析死亡率、标化死亡率、早死导致寿命损失年(years of life lost,YLL)率、平均寿命损失年(average years of life lost,AYLL)及不同死因构成比,死亡率的比较采用χ^(2)检验,率的趋势变化采用平均年度变化百分比(average annual percent of change,AAPC)表示。结果重庆市老年人跌倒死亡率与标化死亡率分别由2012年的30.74/10万、31.60/10万上升到2023年的52.95/10万、44.36/10万,AAPC分别为5.27%与3.09%,变化趋势差异均有统计学意义(P<0.05)。跌倒死亡率均是男性高于女性,差异均有统计学意义(P<0.05)。2012—2019年除了2016年外均是城市老年人跌倒死亡率高于农村地区,2019年后农村地区老年人跌倒死亡率高于城市地区,差异均有统计学意义(P<0.05)。重庆市跌倒导致的YLL率由2012年的4.68‰上升到2023年的7.18‰,AAPC为4.24%,变化趋势差异有统计学意义(P<0.05)。跌倒导致的AYLL由2012年的15.23年下降到13.56年,AAPC为-1.18%,变化趋势差异有统计学意义(P<0.05)。结论重庆市老年跌倒死亡率高于全国平均水平,并呈上升趋势,应重视老年人跌倒的综合干预。展开更多
Burden of disease research plays a pivotal role in global and national health policy by quantifying the impact of illnesses, injuries, and risk factors on populations. Through metrics such as disabilityadjusted life y...Burden of disease research plays a pivotal role in global and national health policy by quantifying the impact of illnesses, injuries, and risk factors on populations. Through metrics such as disabilityadjusted life years (DALYs), years of life lost (YLLs),and years lived with disability (YLDs), it provides a comprehensive assessment of health loss, enabling evidence-based decision-making[1].展开更多
[目的]分析2017—2022年四川省户籍居民恶性肿瘤死亡情况及潜在寿命损失。[方法]死亡数据源自中国疾病预防控制信息系统人口死亡信息登记管理系统,收集2017—2022年四川省31个国家级死因监测点户籍居民死亡登记报告资料,使用SAS 9.4、Jo...[目的]分析2017—2022年四川省户籍居民恶性肿瘤死亡情况及潜在寿命损失。[方法]死亡数据源自中国疾病预防控制信息系统人口死亡信息登记管理系统,收集2017—2022年四川省31个国家级死因监测点户籍居民死亡登记报告资料,使用SAS 9.4、Joinpoint 4.9.1.0软件计算恶性肿瘤死亡率、标化死亡率、年度变化百分比、潜在寿命损失年(potential years of life lost,PYLL)及潜在寿命损失率(potential years of life lost rate,PYLLR)。[结果] 2017—2022年四川省恶性肿瘤死亡率为169.32/10万,标化死亡率为111.26/10万,总人群及分性别恶性肿瘤死亡率均呈显著上升趋势(P均<0.05);恶性肿瘤死因顺位前5位分别是肺癌、肝癌、食管癌、胃癌、结直肠癌。前10位恶性肿瘤死因中肺癌、结直肠癌、胰腺癌、女性乳腺癌、前列腺癌及唇口腔和咽恶性肿瘤死亡率均有明显上升趋势(P均<0.05)。2017—2022年四川省恶性肿瘤所致PYLL合计为1 520 175.00人年,PYLLR为13.98‰。[结论]四川省恶性肿瘤死亡率呈上升趋势,肺癌和消化道恶性肿瘤是造成人群寿命损失的主要恶性肿瘤,应加强重点癌症的早诊早治,降低癌症死亡率。展开更多
基金supported by the National Natural Science Foundation of China(82192903,82192904)the National Science and Technology Major Projects of China(2023ZD0510103)。
文摘Objective Telomere length is a key aging biomarker,but its sex-specific impact on individualized life expectancy remains uncertain.This study explores sex differences in leukocyte telomere length(LTL)and individualized expected years of life lost(YLL).Methods A prospective cohort of 445,399 participants(203,731 males and 241,668 females)from the UK Biobank was analyzed.LTL values were log-transformed,and YLL was calculated using life tables.Multiple linear regression was applied to examine sex-specific associations.Results In males,each standard deviation(S.D.)increase in LTL was linked to a 0.965-year decrease in YLL(95%CI:–1.025,–0.900;P<0.001).In females,longer LTL was related to a 0.102-year increase in YLL(95%CI:0.057,0.146;P<0.001).Among postmenopausal females,LTL showed a protective effect similar to that in males(0.387-year decrease,95%CI:−0.446,–0.328;P<0.001),while premenopausal females exhibited a detrimental association(0.705-year increase,95%CI:0.625,0.785;P<0.001).Comparable trends were observed across major aging-related diseases,pointing to a consistent biological pattern.Conclusion The influence of LTL on life expectancy varies significantly by sex,with protective associations seen in males and postmenopausal females.This suggests hormonal involvement in telomere dynamics.The results support integrating sex-specific perspectives into aging and telomere research and clinical practice.
基金financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nível Superior-Brasil(CAPES)-Finance Code 001.
文摘Introduction: Indicators of maternal health are often used to evaluate the social development and overall health of a population, as well as the accessibility of health services. Among these indicators, the Potential Years of Life Lost, which is associated with maternal deaths, is useful for the definition of priorities, monitoring, evaluation, and intervention, identifying the highest risk groups. Objective: To analyze the Potential Years of Life Lost by maternal death in Santa Catarina in 2000 and 2014. Method: An Ecological study with exploratory spatial analysis was conducted with data obtained from the Information System on Mortality and Live Births. Results: In the Information System, 35 maternal deaths in the year 2000 were identified and 24 in 2014. The total estimated years of life lost were 845 years in 2000 and 780 years in 2014, dominated by direct obstetric causes. In 2000, women who died lost, on average, 39.8 years of life;and 41.5 years in 2014. Conclusion: The spatial pattern observed in 2000 highlights areas of high risk in different regions of Santa Catarina. The greatest loss of years occurred in younger women, confirming the need to prevent and control maternal mortality and review strategies for compliance with public policies in the State.
文摘The magnitude of the overall prevalence and racial disparity in induced abortion suggests that it is a major influence on the demographic and socioeconomic composition of the population of the United States (US). However, the years of potential lives averted by induced abortion have not been systematically studied. We applied race-specific intra-uterine death estimates to the induced abortions occurring to non-Hispanic (NH) white and non-Hispanic (NH) black women in the US state of North Carolina in 2008. The resultant estimate of births averted by induced abortion was used to project years of potential life lost. All-cause detailed mortality data were used to compare induced abortion with other contributing causes of years of potential life lost before age 75 (YPLL 75). For NH whites, induced abortions in 2008 contributed 59% of total YPLL 75, and 1.5 times the total YPLL 75 from all other causes combined. For NH blacks, induced abortions in 2008 contributed 76% of total YPLL 75 and 3.2 times the total YPLL 75 from all other causes combined. Induced abortion is the overwhelmingly predominant contributing cause of preventable potential lives lost in the North Carolina population, and NH blacks are disproportionately affected.
基金the National Key Research&Development Program of the Ministry of Science and Technology of the People’s Republic of China(No.2018YFC1315301)Taikang Yicai Public Health and Epidemic Control Fund.
文摘Background:Colorectal cancer(CRC)is the fourth cause of cancer death in China.We aimed to provide national and subnational estimates and changes of CRC premature mortality burden during 2005–2020.Methods:Data from multi-source on the basis of the national surveillance mortality system were used to estimate mortality and years of life lost(YLL)of CRC in the Chinese population during 2005–2020.Estimates were generated and compared for 31 provincial-level administrative divisions in China.Results:Estimated CRC deaths increased from 111.41 thousand in 2005 to 178.02 thousand in 2020;age-standardized mortality rate decreased from 10.01 per 100,000 in 2005 to 9.68 per 100,000 in 2020.Substantial reduction in CRC premature mortality burden,as measured by age-standardized YLL rate,was observed with a reduction of 10.20%nationwide.Marked differences were observed in the geographical patterns of provincial units,and they appeared to be obvious in areas with higher economic development.Population aging was the dominant driver which contributed to the increase in CRC deaths,followed by population growth and age-specific mortality change.Conclusions:Substantial discrepancies were observed in the premature mortality burden of CRC across China.Targeted considerations were needed to promote a healthy lifestyle,expand cost-effective CRC early screening and diagnosis,and improve medical treatment to reduce CRC mortality among high-risk populations and regions with inadequate healthcare resources.
文摘Purpose： Traffic injuries are among the leading causes of mortality and morbidity worldwide. Pedestrians have been considered as a high-risk group among road users, especially in middle- or low-income communities. This study attempted to determine the burden of pedestrians＇ fatalities in Fars, the southern province of Iran using years of life lost （YLL） approach. Methods： The data used in this study were retrieved from Fars Forensic Medicine Organization database on pedestrian traffic accidents. The YLL from 2009 to 2013 was estimated using the method presented by World Health organization. Some epidemiological characteristics of pedestrians＇ fatalities were analyzed by SPSS. Results： Although YLL among 1000 male pedestrians decreased from 2.5 in 2009 to 1.5 in 2013, it increased from 0.9 to 2.1 among 1000 females during the same period. Higher proportion of death was found in female, illiterate, and married pedestrians {p 〈 0.001 ）. In addition, mortality was higher in pedestrians living the cities, during daytime, at home, and in hospitals （p 〈 0.001 ）. Conclusion： Consistent with the global trends, burden of pedestrian accidents in Fats was also excep- tionally high. Considering the national and cultural aspects of different countries, improving the safety of pedestrians demands a multi-dimensional approach with interventional factors concerning policies, rules, pedestrians, motor vehicles and environmental conditions taken into consideration.
基金We thank Professor Antonio Gasparrini for providing assistance during statistical analysis.This work was supported by the National Key Research and Development Program of China(2018YFA0606200)Guangzhou Science and Technology Project(201704020194)+3 种基金and the Guangdong Health Innovation Platform.The funders were not involved in the research and preparation of the article,including study designcollection,analysis,and interpretation of datawriting of the articleand the decision to submit it for publication.
文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics.
文摘目的分析2012—2023年重庆市老年人自杀死亡率与死亡疾病负担变化趋势,为开展有针对性的干预提供建议。方法利用重庆市2012—2023年死因监测数据中根本死因为自杀(《国际疾病与相关健康问题统计分类第10版》编码:X60~X84、Y87)的60岁及以上老年人死亡个案,分析死亡率、标化死亡率、早死寿命损失年(years of life lost,YLL)率、平均寿命损失年(average years of life lost,AYLL)及不同死因构成比,比较不同性别和地区死亡率,率的趋势变化采用年度变化百分比(annual percent of change,APC)和平均年度变化百分比(average annual percent of change,AAPC)进行分析。结果2012—2023年60岁及以上老年人自杀死亡率与标化死亡率总体呈下降的趋势,分别以年均3.54%与4.02%下降,变化趋势均有统计学意义(P<0.05)。2012—2016年自杀死亡率以年均4.53%上升,2016—2021年以年均8.91%下降,变化趋势均有统计学意义(P<0.05)。仅2020年与2022年男性自杀死亡率高于女性(P<0.05)。2012—2023年男性自杀死亡率与标化死亡率分别以年均2.86%和3.44%下降,女性分别以年均4.21%和4.69%下降,变化趋势均有统计学意义(P<0.05)。农村地区老年人历年自杀死亡率均高于城市地区,差异均有统计学意义(P<0.05)。2012—2023年城市地区老年人自杀死亡率与标化死亡率均保持相对平稳的水平(P>0.05),而农村地区老年人自杀死亡率与标化死亡率分别以年均3.44%与4.02%下降(P<0.05)。60岁及以上老年人自杀导致的YLL率与AYLL分别由2012年的3.03‰与18.54年下降至2023年的2.26‰与17.50年,AAPC分别为-4.02%与-0.60%,变化趋势均有统计学意义(P<0.05)。比较历年不同自杀方式构成发现,杀虫剂中毒死亡占比呈下降的趋势,而悬吊死亡、从高处跳下、淹溺占比均呈上升的趋势(P<0.05)。结论重庆市60岁及以上老年人自杀死亡率较高,疾病负担较重,总体呈下降的趋势,应重视老年人自杀的早期识别与干预。
文摘目的分析1992—2021年我国血吸虫病疾病负担变化趋势、预测2022—2030年我国血吸虫病疾病负担,为我国血吸虫病消除工作提供参考。方法从全球疾病负担研究(global burden of disease,GBD)数据库中获取1992—2021年我国、全球及不同社会人口学指数(socio-demographic index,SDI)地区人群血吸虫病患病率、年龄标化患病率、伤残调整寿命年(disability adjusted life year,DALYs)率、年龄标化DALYs率及归因于血吸虫感染的贫血伤残损失寿命年(years lost due to disability,YLDs)率、归因于血吸虫感染的贫血年龄标化YLDs率,计算各指标估计年度变化百分比(estimated annual percentage change,EAPC)及其95%可信区间(confidence Interval,CI)以分析疾病负担变化趋势。采用年龄-时期-队列(age-period-cohort,APC)模型分析1992—2021年我国人群血吸虫病患病率随年龄、时期和出生队列的变化趋势,采用贝叶斯年龄-时期-队列(Bayesian age-period-cohort,BAPC)模型预测2022—2030年我国血吸虫病疾病负担。结果2021年,我国人群血吸虫病年龄标化患病率为761.32/10万、年龄标化DALYs率为5.55/10万、归因于血吸虫感染的贫血年龄标化YLDs率为0.38/10万,均低于全球水平(分别为1914.30/10万、21.90/10万、3.36/10万)及中SDI地区(1413.61/10万、12.10/10万、1.93/10万)、低-中SDI地区(分别为2461.03/10万、26.81/10万、4.48/10万)和低SDI地区(分别为5832.77/10万、94.48/10万、10.65/10万),但高于高SDI地区(分别为59.47/10万、0.49/10万、0.05/10万)和高-中SDI地区(分别为123.11/10万、1.20/10万、0.12/10万)。2021年,我国男性人群血吸虫病患病率(820.79/10万)、DALYs率(5.86/10万)均高于女性人群(分别为697.96/10万、5.23/10万);女性人群归因于血吸虫感染的贫血YLDs率(0.66/10万)高于男性(0.12/10万);不同性别人群血吸虫病患病率高峰均为30~34岁组,男性、女性人群血吸虫病DALYs率高峰分别为15~19岁与20~24岁。与不同SDI地区人群比较,1992—2021年我国人群血吸虫病年龄标化患病率下降速度中等[EAPC=-1.51%,95%CI:(-1.65%,-1.38%)],年龄标化DALYs率[EAPC=-3.61%,95%CI:(-3.90%,-3.33%)]与归因于血吸虫感染的贫血年龄标化YLDs率[EAPC=-4.16%,95%CI:(-4.38%,-3.94%)]下降速度均最快。APC模型建模结果显示,1992—2021年我国人群血吸虫病患病率变化具有年龄、时期和队列效应,随年龄增长先上升后下降、随时期递进和出生队列推移均下降。BAPC模型预测显示,2022—2030年我国人群血吸虫病年龄标化患病率、年龄标化DALYs率和归因于血吸虫感染的贫血年龄标化YLDs率均呈下降趋势,2030年分别为722.72/10万[95%CI:(538.74/10万,906.68/10万)]、5.19/10万[95%CI:(3.54/10万,6.84/10万)]和0.30/10万[95%CI:(0.21/10万,0.39/10万)]。结论1992—2021年我国血吸虫病疾病负担呈下降趋势,预测2022—2030年我国血吸虫病疾病负担亦呈下降趋势。年龄、时期和队列均对人群血吸虫病患病率存在影响,需结合流行现状和防控需求精准开展消除血吸虫病工作。
文摘目的分析2012—2023年重庆市老年人跌倒死亡率与疾病负担变化趋势,为开展有针对性地干预提供建议。方法利用2012—2023年死因监测数据中根本死因为跌倒(ICD-10:W00-W19)的死亡个案,采用SPSS 26.0统计软件分析死亡率、标化死亡率、早死导致寿命损失年(years of life lost,YLL)率、平均寿命损失年(average years of life lost,AYLL)及不同死因构成比,死亡率的比较采用χ^(2)检验,率的趋势变化采用平均年度变化百分比(average annual percent of change,AAPC)表示。结果重庆市老年人跌倒死亡率与标化死亡率分别由2012年的30.74/10万、31.60/10万上升到2023年的52.95/10万、44.36/10万,AAPC分别为5.27%与3.09%,变化趋势差异均有统计学意义(P<0.05)。跌倒死亡率均是男性高于女性,差异均有统计学意义(P<0.05)。2012—2019年除了2016年外均是城市老年人跌倒死亡率高于农村地区,2019年后农村地区老年人跌倒死亡率高于城市地区,差异均有统计学意义(P<0.05)。重庆市跌倒导致的YLL率由2012年的4.68‰上升到2023年的7.18‰,AAPC为4.24%,变化趋势差异有统计学意义(P<0.05)。跌倒导致的AYLL由2012年的15.23年下降到13.56年,AAPC为-1.18%,变化趋势差异有统计学意义(P<0.05)。结论重庆市老年跌倒死亡率高于全国平均水平,并呈上升趋势,应重视老年人跌倒的综合干预。
文摘Burden of disease research plays a pivotal role in global and national health policy by quantifying the impact of illnesses, injuries, and risk factors on populations. Through metrics such as disabilityadjusted life years (DALYs), years of life lost (YLLs),and years lived with disability (YLDs), it provides a comprehensive assessment of health loss, enabling evidence-based decision-making[1].
文摘[目的]分析2017—2022年四川省户籍居民恶性肿瘤死亡情况及潜在寿命损失。[方法]死亡数据源自中国疾病预防控制信息系统人口死亡信息登记管理系统,收集2017—2022年四川省31个国家级死因监测点户籍居民死亡登记报告资料,使用SAS 9.4、Joinpoint 4.9.1.0软件计算恶性肿瘤死亡率、标化死亡率、年度变化百分比、潜在寿命损失年(potential years of life lost,PYLL)及潜在寿命损失率(potential years of life lost rate,PYLLR)。[结果] 2017—2022年四川省恶性肿瘤死亡率为169.32/10万,标化死亡率为111.26/10万,总人群及分性别恶性肿瘤死亡率均呈显著上升趋势(P均<0.05);恶性肿瘤死因顺位前5位分别是肺癌、肝癌、食管癌、胃癌、结直肠癌。前10位恶性肿瘤死因中肺癌、结直肠癌、胰腺癌、女性乳腺癌、前列腺癌及唇口腔和咽恶性肿瘤死亡率均有明显上升趋势(P均<0.05)。2017—2022年四川省恶性肿瘤所致PYLL合计为1 520 175.00人年,PYLLR为13.98‰。[结论]四川省恶性肿瘤死亡率呈上升趋势,肺癌和消化道恶性肿瘤是造成人群寿命损失的主要恶性肿瘤,应加强重点癌症的早诊早治,降低癌症死亡率。
