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Construction of a Marketing System for Leveled Mathematics Readers from a User-Oriented Perspective: A Strategy Optimization Study Based on the 4V Marketing Model
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作者 Zhaoyong Ouyang Guanlin Liu 《Proceedings of Business and Economic Studies》 2025年第5期39-44,共6页
In the context of the continuous deepening of the“Double Reduction”policy and the growing demand for quality education,leveled mathematics readers,as an emerging form of publishing that integrates subject education ... In the context of the continuous deepening of the“Double Reduction”policy and the growing demand for quality education,leveled mathematics readers,as an emerging form of publishing that integrates subject education and reading experience,face challenges such as unclear leveling logic,insufficient functional support,and weak user engagement.This paper introduces the 4V marketing theory and constructs an analytical framework from four dimensions:differentiation,functionality,added value,and resonance.Two representative products,“Climbing Mathematics”and“Spark Mathematics,”are selected for a typical case comparison to identify their strengths and weaknesses in content design,service systems,and brand operation,and to extract transferable strategic elements.The study finds that the user-value-oriented strategy based on the 4V model can effectively address the core issues in the market promotion and user relationship building of leveled mathematics readers,providing practical paths and theoretical support for educational publishing institutions to achieve product innovation and brand upgrading in this niche field. 展开更多
关键词 4V marketing theory leveled mathematics readers Educational publishing Typical case analysis Marketing strategy
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A Special Report of Visit to Director Zhang Xiaolu of Department of Science &Technology and Environmental Protection, the State Power Corporation of China──Top Leveled Enterprise Must Possess Top Leveled Science & Technology Innovation Ability
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《Electricity》 2000年第2期30-36,共7页
关键词 A Special Report of Visit to Director Zhang Xiaolu of Innovation Department of Science Power Corporation of China Technology Innovation Ability Technology and Environmental Protection Top leveled Enterprise Must Possess Top leveled Science the State ZHANG
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基于Level Set方法的HG-80钢晶粒长大模型的建模与仿真
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作者 刘铭阳 陈学文 +5 位作者 周正 毛怡然 徐栋栋 李强 易浩 周旭东 《材料热处理学报》 北大核心 2025年第6期162-170,共9页
为了准确预测HG-80钢的晶粒长大过程并调控其微观组织,在900~1200℃的保温温度和10~1200s的保温时间条件下,采用Gleeble-1500D型热模拟机对其进行等温保温实验,分析其晶粒长大过程,并基于实验数据建立了Burke-Turnbull晶粒长大动力学模... 为了准确预测HG-80钢的晶粒长大过程并调控其微观组织,在900~1200℃的保温温度和10~1200s的保温时间条件下,采用Gleeble-1500D型热模拟机对其进行等温保温实验,分析其晶粒长大过程,并基于实验数据建立了Burke-Turnbull晶粒长大动力学模型。通过二次开发将计算所得的Burke-Turnbull模型参数导入DIGIMU■软件中,从晶粒尺寸分布、晶粒生长动力学和晶粒拓扑结构等方面,基于Level Set方法建立了描述HG-80钢的晶粒长大模型并通过DIGIMU■软件进行仿真计算。结果表明:随着保温时间的增加,实验钢的晶粒尺寸明显增大,晶粒生长速率逐渐减小,呈抛物线状增长;为了验证Burke-Turnbull模型的准确性,将平均晶粒尺寸的模型预测值与实验值进行对比,相关系数R为0.991,表明该模型的准确性较高;通过Level Set方法仿真计算得出的晶粒形貌与实验结果吻合良好,证明该模型能有效预测不同热处理条件下HG-80钢的晶粒长大过程。 展开更多
关键词 HG-80钢 Level Set方法 晶粒长大 Burke-Turnbull模型
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Early Opportunities for Onshore and Offshore CCUS Deployment in the Chinese Cement Industry 被引量:3
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作者 Jing-Li Fan Yifan Mao +1 位作者 Kai Li Xian Zhang 《Engineering》 2025年第3期348-362,共15页
The promotion of deep decarbonization in the cement industry is crucial for mitigating global climate change,a key component of which is carbon capture,utilization,and storage(CCUS)technology.Despite its importance,th... The promotion of deep decarbonization in the cement industry is crucial for mitigating global climate change,a key component of which is carbon capture,utilization,and storage(CCUS)technology.Despite its importance,there is a lack of empirical assessments of early opportunities for CCUS implementation in the cement sector.In this study,a comprehensive onshore and offshore source–sink matching optimization assessment framework for CCUS retrofitting in the cement industry,called the SSM-Cement framework,is proposed.The framework comprises four main modules:the cement plant suitability screening module,the storage site assessment module,the source–sink matching optimization model module,and the economic assessment module.By applying this framework to China,919 candidates are initially screened from 1132 existing cement plants.Further,603 CCUS-ready cement plants are identified,and are found to achieve a cumulative emission reduction of 18.5 Gt CO_(2) from 2030 to 2060 by meeting the CCUS feasibility conditions for constructing both onshore and offshore CO_(2) transportation routes.The levelized cost of cement(LCOC)is found to range from 30 to 96(mean 73)USD·(t cement)^(-1),while the levelized carbon avoidance cost(LCAC)ranges from^(-5) to 140(mean 88)USD·(t CO_(2))^(-1).The northeastern and northwestern regions of China are considered priority areas for CCUS implementation,with the LCAC concentrated in the range of 35 to 70 USD·(t CO_(2))^(-1).In addition to onshore storage of 15.8 Gt CO_(2) from 2030 to 2060,offshore storage would contribute 2.7 Gt of decarbonization for coastal cement plants,with comparable LCACs around 90 USD·(t CO_(2))^(-1). 展开更多
关键词 Cement industry Carbon capture utilization and storage Levelized cost of cement Source-sink matching Offshore storage continental shale oil
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The Electric Vehicle Surge:Effective Solutions for Charging Challenges with Advanced Converter Technologies 被引量:1
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作者 Rajanand Patnaik Narasipuram Md M.Pasha +1 位作者 Saleha Tabassum Amit Singh Tandon 《Energy Engineering》 2025年第2期431-469,共39页
The global adoption of Electric Vehicles(EVs)is on the rise due to their advanced features,with projections indicating they will soon dominate the private vehicle market.However,improper management of EV charging can ... The global adoption of Electric Vehicles(EVs)is on the rise due to their advanced features,with projections indicating they will soon dominate the private vehicle market.However,improper management of EV charging can lead to significant issues.This paper reviews the development of high-power,reliable charging solutions by examining the converter topologies used in rectifiers and converters that transfer electricity from the grid to EV batteries.It covers technical details,ongoing developments,and challenges related to these topologies and control strategies.The integration of rapid charging stations has introduced various Power Quality(PQ)issues,such as voltage fluctuations,harmonic distortion,and supra-harmonics,which are discussed in detail.The paper also highlights the benefits of controlled EV charging and discharging,including voltage and frequency regulation,reactive power compensation,and improved power quality.Efficient energy management and control strategies are crucial for optimizing EV battery charging within microgrids to meet increasing demand.Charging stations must adhere to specific converter topologies,control strategies,and industry standards to function correctly.The paper explores microgrid architectures and control strategies that integrate EVs,energy storage units(ESUs),and Renewable Energy Sources(RES)to enhance performance at charging points.It emphasizes the importance of various RES-connected architectures and the latest power converter topologies.Additionally,the paper provides a comparative analysis of microgrid-based charging station architectures,focusing on energy management,control strategies,and charging converter controls.The goal is to offer insights into future research directions in EV charging systems,including architectural considerations,control factors,and their respective advantages and disadvantages. 展开更多
关键词 Electric vehicles CONVERTERS RECTIFIERS power and voltage levels efficiency supra-harmonics
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Smoke and NO_(x)emission characteristics of in-use construction machinery base on substantial field measurement:A case study in Beijing,China 被引量:1
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作者 Huawei Yi Yangyang Cui +7 位作者 Lijun Zhu Yan Shen Han Li Guanghan Huang Linzhen Qu Dongdong Guo Lei Nie Yifeng Xue 《Journal of Environmental Sciences》 2025年第3期386-393,共8页
To understand the smoke level and NO_(x)emission characteristics of in-use construction machinery in Beijing,we selected 905 construction machines in Beijing from August 2022 to April 2023 to monitor the emission leve... To understand the smoke level and NO_(x)emission characteristics of in-use construction machinery in Beijing,we selected 905 construction machines in Beijing from August 2022 to April 2023 to monitor the emission level of smoke and NO_(x).The exhaust smoke level and excessive emission situation of different machinery types were identified,and their NO_(x)emission levels were monitored according to the free acceleration method.We investigated the correlation of NO_(x)and smoke emission,and proposed suggestions for controlling pollution discharge from construction machinery in the future.The results show that the exhaust smoke level was 0–2.62 m^(−1),followed a log-normal distribution(μ=-1.73,δ=1.09,R^(2)=0.99),with a 5.64%exceedance rate.Differenceswere observed amongmachinery types,with low-power engine forklifts showing higher smoke levels.The NO_(x)emission range was 71–1516 ppm,followed a normal distribution(μ=565.54,δ=309.51,R^(2)=0.83).Differences among machinery types were relatively small.Engine rated net power had the most significant impact on NO_(x)emissions.Thus,NO_(x)emissions from construction machinery need further attention.Furthermore,we found a weak negative correlation(p<0.05)between the emission level of smoke and NO_(x),that is the synergic emission reduction effect is poor,emphasizing the need for NO_(x)emission limits.In the future,the oversight in Beijing should prioritize phasing out ChinaⅠand ChinaⅡmachinery,and monitor emissions from highpower engine ChinaⅢmachinery. 展开更多
关键词 Fuel-oil construction machinery SMOKE NO_(x) Emission level Regulatory suggestion
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Enhanced electrode-level diagnostics for lithium-ion battery degradation using physics-informed neural networks 被引量:1
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作者 Rui Xiong Yinghao He +2 位作者 Yue Sun Yanbo Jia Weixiang Shen 《Journal of Energy Chemistry》 2025年第5期618-627,共10页
For the diagnostics and health management of lithium-ion batteries,numerous models have been developed to understand their degradation characteristics.These models typically fall into two categories:data-driven models... For the diagnostics and health management of lithium-ion batteries,numerous models have been developed to understand their degradation characteristics.These models typically fall into two categories:data-driven models and physical models,each offering unique advantages but also facing limitations.Physics-informed neural networks(PINNs)provide a robust framework to integrate data-driven models with physical principles,ensuring consistency with underlying physics while enabling generalization across diverse operational conditions.This study introduces a PINN-based approach to reconstruct open circuit voltage(OCV)curves and estimate key ageing parameters at both the cell and electrode levels.These parameters include available capacity,electrode capacities,and lithium inventory capacity.The proposed method integrates OCV reconstruction models as functional components into convolutional neural networks(CNNs)and is validated using a public dataset.The results reveal that the estimated ageing parameters closely align with those obtained through offline OCV tests,with errors in reconstructed OCV curves remaining within 15 mV.This demonstrates the ability of the method to deliver fast and accurate degradation diagnostics at the electrode level,advancing the potential for precise and efficient battery health management. 展开更多
关键词 Lithium-ion batteries Electrode level Ageing diagnosis Physics-informed neural network Convolutional neural networks
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Low-profile,low sidelobe array antenna with ultrawide beam coverage for UAV communication 被引量:1
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作者 Mei LI Zhiliang SHANG +2 位作者 Lin PU Ming-Chun TANG Lei ZHU 《Chinese Journal of Aeronautics》 2025年第1期444-454,共11页
This paper presents a design method to implement an antenna array characterized by ultra-wide beam coverage,low profile,and low Sidelobe Level(SLL)for the application of Unmanned Aerial Vehicle(UAV)air-to-ground commu... This paper presents a design method to implement an antenna array characterized by ultra-wide beam coverage,low profile,and low Sidelobe Level(SLL)for the application of Unmanned Aerial Vehicle(UAV)air-to-ground communication.The array consists of ten broadside-radiating,ultrawide-beamwidth elements that are cascaded by a central-symmetry series-fed network with tapered currents following Dolph-Chebyshev distribution to provide low SLL.First,an innovative design of end-fire Huygens source antenna that is compatible with metal ground is presented.A low-profile,half-mode Microstrip Patch Antenna(MPA)is utilized to serve as the magnetic dipole and a monopole is utilized to serves as the electric dipole,constructing the compact,end-fire,grounded Huygens source antenna.Then,two opposite-oriented end-fire Huygens source antennas are seamlessly integrated into a single antenna element in the form of monopole-loaded MPA to accomplish the ultrawide,broadside-radiating beam.Particular consideration has been applied into the design of series-fed network as well as antenna element to compensate the adverse coupling effects between elements on the radiation performance.Experiment indicates an ultrawide Half-Power Beamwidth(HPBW)of 161°and a low SLL of-25 dB with a high gain of 12 d Bi under a single-layer configuration.The concurrent ultrawide beamwidth and low SLL make it particularly attractive for applications of UAV air-to-ground communication. 展开更多
关键词 Array antenna Broad beam Fan beam Low sidelobe level Chebyshev synthesis UAV communication
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Recent advances in interfacial engineering for high-efficiency perovskite photovoltaics 被引量:1
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作者 Zhijie Wang Cheng Gong +4 位作者 Cong Zhang Chenxu Zhao Tzu-Sen Su Haiyun Li Hong Zhang 《DeCarbon》 2025年第2期10-23,共14页
Through strategies such as process optimization,solvent selection,and component tuning,the crystallization of perovskite materials has been effectively controlled,enabling perovskite solar cells(PSCs)to achieve over 2... Through strategies such as process optimization,solvent selection,and component tuning,the crystallization of perovskite materials has been effectively controlled,enabling perovskite solar cells(PSCs)to achieve over 25%power conversion efficiency(PCE).However,as PCE continues to improve,interfacial issues within the devices have emerged as critical bottlenecks,hindering further performance enhancements.Recently,interfacial engineering has driven transformative progress,pushing PCEs to nearly 27%.Building upon these developments,this review first summarizes the pivotal role of interfacial modifications in elevating device performance and then,as a starting point,provides a comprehensive overview of recent advancements in normal,inverted,and tandem structure devices.Finally,based on the current progress of PSCs,preliminary perspectives on future directions are presented. 展开更多
关键词 Perovskite solar cells Interfacial engineering Defect passivation Energy level alignment Ion migration Device stability
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Effect of hospital-community-home collaborative health management on symptoms,cognition,anxiety,and depression in high-risk individuals for stroke 被引量:1
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作者 Jing Wang Chen-Xi Zhao +5 位作者 Jin Tian Yan-Ru Li Kai-Fang Ma Rui Du Meng-Kun Li Rui Hu 《World Journal of Psychiatry》 2025年第3期78-87,共10页
BACKGROUND Effective health management for high-risk stroke populations is essential.The hospital-community-home(HCH)collaborative health management(CHM)model leverages resources from hospitals,communities,and familie... BACKGROUND Effective health management for high-risk stroke populations is essential.The hospital-community-home(HCH)collaborative health management(CHM)model leverages resources from hospitals,communities,and families.By integrating patient information across these three domains,it facilitates the delivery of tailored guidance,health risk assessments,and three-in-one health education.AIM To explore the effects of the HCH-CHM model on stroke risk reduction in highrisk populations.METHODS In total,110 high-risk stroke patients screened in the community from January 2019 to January 2023 were enrolled,with 52 patients in the control group receiving routine health education and 58 in the observation group receiving HCH-CHM model interventions based on routine health education.Stroke awareness scores,health behavior levels,medication adherence,blood pressure,serum biochemical markers(systolic/diastolic blood pressure,total cholesterol,and triglyceride),and psychological measures(self-rating anxiety/depression scale)were evaluated and compared between groups.RESULTS The observation group showed statistically significant improvements in stroke awareness scores and health behavior levels compared to the control group(P<0.05),with notable enhancements in lifestyle and dietary habits(P<0.05)and reductions in postintervention systolic blood pressure,diastolic blood pressure,total cholesterol,triglyceride,self-rating anxiety scale,and self-rating depression scale scores(P<0.05).CONCLUSION The HCH-CHM model had a significant positive effect on high-risk stroke populations,effectively increasing disease awareness,improving health behavior and medication adherence,and appropriately ameliorating blood pressure,serum biochemical marker levels,and negative psychological symptoms. 展开更多
关键词 Hospital-community-home-collaborative health management model High-risk populations for stroke Stroke awareness score Health behavior level Hospital-community-home
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Characteristics and outcomes of trauma patients with unplanned intensive care unit admissions:Bounce backs and upgrades comparison 被引量:1
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作者 Alexander A Fokin Joanna Wycech Knight +4 位作者 Phoebe K Gallagher Justin Fengyuan Xie Kyler C Brinton Madison E Tharp Ivan Puente 《World Journal of Critical Care Medicine》 2025年第2期105-120,共16页
BACKGROUND The need for an emergency upgrade of a hospitalized trauma patient from the floor to the trauma intensive care unit(ICU)is an unanticipated event with possible life-threatening consequences.Unplanned ICU ad... BACKGROUND The need for an emergency upgrade of a hospitalized trauma patient from the floor to the trauma intensive care unit(ICU)is an unanticipated event with possible life-threatening consequences.Unplanned ICU admissions are associated with increased morbidity and mortality and are an indicator of trauma service quality.Two different types of unplanned ICU admissions include upgrades(patients admitted to the floor then moved to the ICU)and bounce backs(patients admitted to the ICU,discharged to the floor,and then readmitted to the ICU).Previous studies have shown that geriatric trauma patients are at higher risk for unfavorable outcomes.AIM To analyze the characteristics,management and outcomes of trauma patients who had an unplanned ICU admission during their hospitalization.METHODS This institutional review board approved,retrospective cohort study examined 203 adult trauma patients with unplanned ICU admission at an urban level 1 trauma center over a six-year period(2017-2023).This included 134 upgrades and 69 bounce backs.Analyzed variables included:(1)Age;(2)Sex;(3)Comorbidities;(4)Mechanism of injury(MOI);(5)Injury severity score(ISS);(6)Glasgow Coma Scale(GCS);(7)Type of injury;(8)Transfusions;(9)Consultations;(10)Timing and reason for unplanned admission;(11)Intubations;(12)Surgical interventions;(13)ICU and hospital lengths of stay;and(14)Mortality.RESULTS Unplanned ICU admissions comprised 4.2%of total ICU admissions.Main MOI was falls.Mean age was 70.7 years,ISS was 12.8 and GCS was 13.9.Main injuries were traumatic brain injury(37.4%)and thoracic injury(21.7%),and main reason for unplanned ICU admission was respiratory complication(39.4%).The 47.3%underwent a surgical procedure and 46.8%were intubated.Average timing for unplanned ICU admission was 2.9 days.Bounce backs occurred half as often as upgrades,however had higher rates of transfusions(63.8%vs 40.3%,P=0.002),consultations(4.8 vs 3.0,P<0.001),intubations(63.8%vs 38.1%%,P=0.001),longer ICU lengths of stay(13.2 days vs 6.4 days,P<0.001)and hospital lengths of stay(26.7 days vs 13.0 days,P<0.001).Mortality was 25.6%among unplanned ICU admissions,31.9%among geriatric unplanned ICU admissions and 11.9%among all trauma ICU patients.CONCLUSION Unplanned ICU admissions constituted 4.2%of total ICU admissions.Respiratory complications were the main cause of unplanned ICU admissions.Bounce backs occurred half as often as upgrades,but were associated with worse outcomes. 展开更多
关键词 Unplanned intensive care unit admissions Trauma intensive care unit Bounce backs Upgrades Level 1 trauma center Geriatric trauma patients Quality of care indicator
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A 100-degree lithospheric magnetic field model constructed using MSS-1,Swarm-A,and CHAMP satellite data 被引量:1
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作者 JiaXuan Zhang Yan Feng +3 位作者 Pan Zhang YuXuan Lin XinWu Li Ya Huang 《Earth and Planetary Physics》 2025年第3期667-676,共10页
By combining data from the Challenging Minisatellite Payload(CHAMP),Swarm-A,and newest Macao Science Satellite-1(MSS-1) missions,we constructed a lithospheric magnetic field model up to spherical harmonic degree N = 1... By combining data from the Challenging Minisatellite Payload(CHAMP),Swarm-A,and newest Macao Science Satellite-1(MSS-1) missions,we constructed a lithospheric magnetic field model up to spherical harmonic degree N = 100.To isolate the lithospheric magnetic field signals,we utilized the latest CHAOS-8(CHAMP,Φrsted,and SAC-C 8) model and MGFM(Multisource Geomagnetic Field Model) to remove nonlithospheric sources,including the core field,magnetospheric field,ocean tidal field,and ocean circulation field.Subsequently,orbit-by-orbit processing was applied to both scalar and vector data,such as spherical harmonic high-pass filtering,singular spectrum analysis,and line leveling,to suppress noise and residual signals along the satellite tracks.With an orbital inclination of only 41°,MSS-1 effectively captures fine-scale lithospheric magnetic field signals in mid-to low-latitude regions.Its data exhibit a root mean square error of only 0.77 nT relative to the final model,confirming the high quality and utility of lithospheric field modeling.The resulting model exhibits excellent consistency with the MF7(Magnetic Field Model 7),maintaining a high correlation up to N = 90 and still exceeding 0.65 at N = 100.These results demonstrate the reliability and value of MSS-1 data in global lithospheric magnetic field modeling. 展开更多
关键词 lithospheric magnetic field Macao Science Satellite-1(MSS-1) line leveling Magnetic Field Model 7(MF7) singular spectrum analysis
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An Approximation Method for Singular Trudinger-Moser Inequality
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作者 ZHU Maochun XU Wenyan JIANG Rou 《应用数学》 北大核心 2025年第1期64-70,共7页
In this paper,we construct a power type functional which is the approximation functional of the Singular Trudinger-Moser functional.Moreover,we obtain the concentration level of the functional and show it converges to... In this paper,we construct a power type functional which is the approximation functional of the Singular Trudinger-Moser functional.Moreover,we obtain the concentration level of the functional and show it converges to the concentration level of singular Trudinger-Moser functional on the unit ball. 展开更多
关键词 Singular Trudinger-Moser inequality Approximation functional Concentration level
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Impact of community public health care on treatment effect,health cognition,and self-management in patients with type 2 diabetes
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作者 Hong Shi Chun Liu Hong-Yan Luo 《World Journal of Clinical Cases》 SCIE 2025年第5期22-29,共8页
BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T... BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease progression.AIM To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with T2DM.METHODS One hundred patients with T2DM were selected as the research subjects.The patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table method.The conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing group.The rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two groups.RESULTS The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P<0.05).Before care,there was no significant difference in fasting blood glucose or 2-h postprandial blood glucose between the two groups of patients(P>0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(P<0.05).Compared with the scores before care,the cognitive level score for diabetes and self-management ability score improved after care in both groups.The cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than that of the conventional nursing group(98%vs 86%,P<0.05).CONCLUSION Community public health care based on conventional care of T2DM can achieve better blood sugar control,and improve patients’health cognitive level and self-management ability. 展开更多
关键词 Community public health care Type 2 diabetes Blood sugar control Self-management ability Cognition level
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Intervention effect and mechanism of Compound Herba Gueldenstaedtiae in a mouse model of breast hyperplasia
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作者 Wu Yilin Tian Hongying +8 位作者 Sun Jiale Jiao Jiajia Zhao Zihan Shao Jinhuan Zhao Kaiyue Zhou Min Li Qian Li Zexin Yue Changwu 《中国组织工程研究》 北大核心 2026年第17期4377-4389,共13页
BACKGROUND:Breast hyperplasia is a common benign breast disease mainly caused by endocrine disorders,manifested as abnormal hyperplasia of breast tissue.In recent years,traditional Chinese medicine compounds and probi... BACKGROUND:Breast hyperplasia is a common benign breast disease mainly caused by endocrine disorders,manifested as abnormal hyperplasia of breast tissue.In recent years,traditional Chinese medicine compounds and probiotics have shown good potential in regulating the endocrine system and improving the intestinal microecology,providing new ideas for the treatment of breast hyperplasia.OBJECTIVE:To explore the effects and mechanisms of traditional Chinese medicine compounds and fermented probiotic compounds on breast hyperplasia in mice,providing new theoretical and experimental bases for the clinical treatment and prevention of breast hyperplasia.METHODS:(1)Network pharmacology tools were used to predict the anti-breast-hyperplasia activity of Herba Gueldenstaedtiae(Euphorbia humifusa),as well as its potential targets and signaling pathways.The databases included:TCMSP,OMIM,GeneCards database,UniProt website,Venny2.1.0 website,Metascape,HERB website,and STRING database,all of which are open-access databases.Network pharmacology can predict and screen key information such as the targets corresponding to the active ingredients of traditional Chinese medicine,disease targets,and action pathways through network analysis and computer-system analysis.Therefore,it has been increasingly widely used in the research of traditional Chinese medicine.(2)A breast hyperplasia model was induced in mice by injecting estrogen and progesterone.Mice in the normal blank group were injected intraperitoneally with normal saline every day.Mice in the model group and drugadministration groups were injected intraperitoneally with estradiol benzoate injection at a concentration of 0.5 mg/kg every day for 25 days.From the 26th day,the injection of estradiol benzoate injection was stopped.Mice in the normal blank group were injected intramuscularly with normal saline every day,and mice in the model group and drug-administration groups were injected intramuscularly with progesterone injection at a concentration of 5 mg/kg for 5 days.After the model was established,each group was given drugs respectively.The normal blank group and the model group were gavaged with 0.2 mL/d of normal saline;the positive blank group(Xiaozheng Pill group)was gavaged with an aqueous solution of Xiaozheng Pill at 0.9 mg/g;the low-,medium-and high-dose groups of Compound Herba Gueldenstaedtiae were gavaged with an aqueous solution of the compound medicine at 0.75,1.5,and 3.0 mg/(g·d)respectively;the low-,medium-and high-dose groups of traditional Chinese medicine-bacteria fermentation were gavaged with an aqueous solution of the compound medicine at 0.75,1.5,and 3.0 mg/(g·d)respectively.The administration was continuous for 30 days.RESULTS AND CONCLUSION:(1)The results of network pharmacology research showed that the Compound Herba Gueldenstaedtiae(Euphorbia humifusa)contained 46 active ingredients,which were related to 1213 potential targets.After comparison with 588 known breast-hyperplasia targets,it was speculated that 50 of these targets might be related to the direct effect of the compound on breast hyperplasia.(2)After drug intervention,there was no significant change in the high-dose group of Compound Herba Gueldenstaedtiae compared with the normal blank group.The liver indicators of the other intervention groups all significantly decreased(P<0.05).(3)In terms of kidney and uterine indicators,the medium-dose group of Compound Herba Gueldenstaedtiae decreased significantly compared with the normal blank group(P<0.05).In terms of the uterine index,the model group increased significantly compared with the normal blank group(P<0.01).(4)After 1-month drug treatment,the number of lobules and acini in the breast tissue of the Xiaozheng Pill group,the low,medium,and high-dose group of Compound Herba Gueldenstaedtiae,the low,medium,and highdose groups of traditional Chinese medicine-bacteria fermentation decreased,and the duct openings narrowed.With the increase of drug dose,diffuse hyperplasia of breast tissue was significantly improved.(5)The ELISA results showed that compared with the model group,the estrogen level was lower in the medium-dose group of traditional Chinese medicine-bacteria fermentation after the intervention(P<0.05).In addition,the follicle-stimulating hormone level in the low-dose group of Compound Herba Gueldenstaedtiae was lower than that of the model group(P<0.05).(6)The intervention in the mouse model led to changes in the abundance of short chain fatty acids and intestinal flora in all groups.To conclude,the Compound Herba Gueldenstaedtiae and its probiotic fermentation products significantly improved mammary gland hyperplasia in mice by regulating hormone levels,improving the structure of the gut microbiota,and increasing the content of shortchain fatty acids,providing new ideas and potential sources of drugs for the treatment of breast hyperplasia. 展开更多
关键词 Herba Gueldenstaedtiae traditional Chinese medicine compound mice with breast hyperplasia microbial fermentation gut microbiota network pharmacology short-chain fatty acids hormone levels inflammatory response endocrine disorders
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Mineralization at Different Structural Levels in the Crust
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作者 LI Saisai ZHANG Hongrui HOU Zengqian 《Acta Geologica Sinica(English Edition)》 2025年第4期1042-1058,共17页
Metallogenic research on structural levels can reveal vertical patterns of mineralization and facilitate the deep exploration of economic minerals.However,research focusing on the correlation between structural levels... Metallogenic research on structural levels can reveal vertical patterns of mineralization and facilitate the deep exploration of economic minerals.However,research focusing on the correlation between structural levels and mineralization remains limited.In this study,we summarize the deformation patterns and associated mineral deposits observed at different crustal levels(i.e.,surface,shallow,middle,and deep structural levels,corresponding to depths of<2,2-8,8-15,and>15 km,respectively).Furthermore,we examine the genetic association between structural levels and metallogenesis,demonstrating that distinct structural levels are linked to specific types of mineralization.Key factors that vary across crustal levels include temperature,pressure,and fluid circulation.Ore-forming processes involve interactions between structures and fluids under varying temperatures and pressures.Structural levels influence mineralization by controlling the temperatures,pressures,and deformation mechanisms that drive the activation,migration,and enrichment of ore-forming materials. 展开更多
关键词 deformation MINERALIZATION structural control structural level crustal level
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Could Glacier Geoengineering Freeze Sea Level Rise?
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作者 Mitch Leslie 《Engineering》 2025年第2期12-14,共3页
The Thwaites Glacier in western Antarctica(Fig. 1) keeps glaciologists and climate scientists awake at night. The 120 kmwide glacier loses about 45 billion tonnes of ice each year, accounting for about 4% of global se... The Thwaites Glacier in western Antarctica(Fig. 1) keeps glaciologists and climate scientists awake at night. The 120 kmwide glacier loses about 45 billion tonnes of ice each year, accounting for about 4% of global sea level rise [1]. If it melted completely, sea levels would climb 65 cm, and follow-on effects could lead to a 3 m increase [2]. But if some scientists' vision becomes reality, in 10–15 years construction crews will sail into the Amundsen Sea off Antarctica to begin building an 80 km long underwater curtain that will shield the glacier from the warm currents that are accelerating its decline [3]. 展开更多
关键词 glaciologists glacier geoengineering sea level rise ice loss global sea level rise Thwaites Glacier thwaites glacier climate scientists
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A review of photovoltaic/thermal(PV/T)incorporation in the hydrogen production process
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作者 Hussein A.Kazem Miqdam T.Chaichan +4 位作者 Ali H.A.Al-Waeli K.Sopian Waheeb E.Alnaser Lawrence Kazmerski Naser W.Alnaser 《Global Energy Interconnection》 2025年第3期363-393,共31页
Integrating the photovoltaic/thermal(PV/T)system in green hydrogen production is an improvement in sustainable energy technologies.In PV/T systems,solar energy is converted into electricity and thermal energy simultan... Integrating the photovoltaic/thermal(PV/T)system in green hydrogen production is an improvement in sustainable energy technologies.In PV/T systems,solar energy is converted into electricity and thermal energy simultaneously using hot water or air together with electricity.This dual use saves a significant amount of energy and officially fights greenhouse gases.Different cooling techniques have been proposed in the literature for improving the overall performance of the PV/T systems;employing different types of agents including nanofluids and phase change materials.Hydrogen is the lightest and most abundant element in the universe and has later turned into a flexible energy carrier for transportation and other industrial applications.Issues,including the processes of Hydrogen manufacturing,preservation as well as some risks act as barriers.This paper provides an analysis of several recent publications on the efficiency of using PV/T technology in the process of green hydrogen production and indicates the potential for its increased efficiency as compared to conventional systems that rely on fossil fuels.Due to the effective integration of solar energy,the PV/T system can play an important role in the reduction of the levelized cost of hydrogen(LCOH)and hence play an important part in reducing the economic calculations of the decarbonized energy system. 展开更多
关键词 PV/T Green hydrogen PRODUCTION Liquification Technology readiness levels Levelized cost of hydrogen
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Effect of minimum and maximum electrical stimulation levels on sound field thresholds,and speech perception in children using the Advanced Bionics Cochlear Implant
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作者 Muthuselvi Thangaraj Ravikumar Arunachalam +1 位作者 Madhuri Gore Ajith Kumar Uppunda 《Journal of Otology》 2025年第3期170-175,共6页
BackgroundIt's crucial to study the effect of changes in thresholds(T)and most comfortable levels(M)on behavioral measurements in young children using cochlear implants.This would help the clinician with the optim... BackgroundIt's crucial to study the effect of changes in thresholds(T)and most comfortable levels(M)on behavioral measurements in young children using cochlear implants.This would help the clinician with the optimization and validation of programming parameters.ObjectiveThe study has attempted to describe the changes in behavioral responses with modification of T and M levels.MethodsTwenty-five participants in the age range 5 to 12 years using HR90K/HiFocus1J or HR90KAdvantage/HiFocus1J with Harmony speech processors participated in the study.A decrease in T levels,a rise in T levels,or a decrease in M levels in the everyday program were used to create experimental programs.Sound field thresholds and speech perception were measured at 50 dBHL for three experimental and everyday programs.ConclusionThe results indicated that only reductions of M levels resulted in significantly(p<0.01)poor aided thresholds and speech perception.On the other hand,variation in T levels did not have significant changes in either sound field thresholds or speech perception.The results highlight that M levels must be correctly established in order to prevent decreased speech perception and audibility. 展开更多
关键词 T levels M levels sound field threshold speech perception
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Design and testing of a liftable chassis for rice harvester
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作者 YANG Ke LI Ju +3 位作者 CHEN Yu LI Hao AO Yu LEI Xiaolong 《智能化农业装备学报(中英文)》 2025年第1期59-70,共12页
During the operation of the rice combine harvester,the fuselage tilts due to the tilt and unevenness of the ground affect its maneuverability and operational reliability.Aiming at the problem of leveling due to the ti... During the operation of the rice combine harvester,the fuselage tilts due to the tilt and unevenness of the ground affect its maneuverability and operational reliability.Aiming at the problem of leveling due to the tilt of the field surface,this research developed an innovative dual-parallelogram chassis lifting mechanism for rice harvesters designed a hydraulic system to adjust the chassis height by extending the cylinder.Using Adams simulation software,a detailed model of the lifting chassis was constructed to analyze its performance,revealing a direct correlation between the hydraulic cylinder extension and chassis elevation.Notably,the mechanism could achieve leveling on slopes with inclination angles of up to 7.5°.Comprehensive evaluations of the liftable chassis system were conducted under both static and dynamic conditions.In the static tests,the system exhibited the capacity for comprehensive or unilateral auto-leveling contingent upon the tilt,with leveling times and angular variations confined to 3.6 s and±0.4°,respectively.In dynamic tests conducted on sloped fields and paddy soils,the system reduced post-leveling mean tilt angles and standard deviations remained below 1.2°and 0.6°,respectively.These results demonstrated a substantial improvement in the stability and reliability of the chassis during operations.This research provides valuable insights into the design and optimization of automatic leveling mechanisms and structural innovations for harvester chassis. 展开更多
关键词 rice combine harvester chassis lifting mechanism hydraulic leveling leveling time
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