期刊文献+
共找到4篇文章
< 1 >
每页显示 20 50 100
氯化锂-匹罗卡品致大鼠急性癫痫模型 被引量:9
1
作者 高旭光 冯体良 王军 《中国血液流变学杂志》 CAS 2003年第4期308-309,312,共3页
目的 建立氯化锂 匹罗卡品化学诱导的大鼠急性癫痫模型。方法 雄性Wistar大鼠 55只 ,随机分为生理盐水对照组、地西泮组和致痫组。氯化锂腹腔注射后 10~ 10h后给予匹罗卡品。结果 生理盐水对照组大鼠均为 0级发作 ,地西泮组中 8只... 目的 建立氯化锂 匹罗卡品化学诱导的大鼠急性癫痫模型。方法 雄性Wistar大鼠 55只 ,随机分为生理盐水对照组、地西泮组和致痫组。氯化锂腹腔注射后 10~ 10h后给予匹罗卡品。结果 生理盐水对照组大鼠均为 0级发作 ,地西泮组中 8只大鼠为 0级发作 ,2只出现Ⅰ级发作 ;致痫组均达到Ⅲ级以上的痫性发作 ,其中Ⅲ级 2只 (2 / 3 5) ,Ⅳ级 3只 (3 / 3 5) ,Ⅴ级 3 0只 (3 0 / 3 5)。致痫组大鼠在匹罗卡品腹注射后 10~ 90min内全部出现急性痫性发作。结论 氯化锂 匹罗卡品诱导的大鼠急性癫痫模型具有制作方便、致痫成功率高和动物死亡率低等特点 。 展开更多
关键词 氯化锂 匹罗卡品 大鼠 急性癫痫模型
暂未订购
Genesis and soil environmental implications of intact in-situ rhizoliths in dunes of the Badain Jaran Desert,northwestern China
2
作者 Qingfeng Sun Kazem Zamanian +3 位作者 Arnaud Huguet Omid Bayat Hong Wang Hanan SBadawy 《Acta Geochimica》 EI CAS CSCD 2022年第5期811-822,共12页
Desert rhizoliths are generally found as weathered,broken and scattered samples on dune field surface,but rarely insitu in their initial states buried under the soil of desert in the Badain Jaran Desert,northwest Chin... Desert rhizoliths are generally found as weathered,broken and scattered samples on dune field surface,but rarely insitu in their initial states buried under the soil of desert in the Badain Jaran Desert,northwest China.This study off ers an assessment of the morphological,mineralogical,and chemical properties of intact and in-situ rhizoliths found in soils of swales and depressions among dune chains.The characteristics of these rare and precious objects were assessed using optical polarizing microscopy,cathodoluminescence,scanning electronic microscopy,radiocarbon dating,and stable isotopic analyses,providing the opportunity for discussion of the rhizolith formation mechanisms and associated environmental conditions.Field and laboratory investigations showed that the in-situ intact rhizoliths were formed only in the places where Artemisia shrubs are living,and the remaining root relicts within rhizoliths belong to this species.The spatial distribution of rhizoliths also suggested that low topographic positions on a landscape provided soil moisture,and redox environments favored rhizolith formation.A semi-closed redox environment in the subsoil at swales and depressions,where water is always present,along with the sandy soil texture,facilitated fast water percolation to deeper depths and condensation.Such a soil environment not only provides water for Artemisia growth,but also for the weathering of minerals such as felspars and calcite from primary carbonates,and for the decomposition of root relicts.Furthermore,harsh climatic conditions,such as strong winds and solar radiation,led to water evaporation through dead root channels and triggered the calcification along the root relicts.The entrapped lithogenic carbonates and to a lesser extent the decomposition of Artemisia roots provided the carbon sources for the rhizoliths formation,while the weathering of soil minerals,particularly feldspars and carbonates,was the main source of Ca.Rhizoliths in the Badain Jaran desert formed relatively quickly,probably over a few soil drying episodes.This led to the entrapment of a large quantity of lithogenic carbonates(more than 90%of carbon)within rhizolith cement.The re-dissolution of the entrapped lithogenic carbonates in rhizolith tubes should be taken into account in the paleoenvironmental interpretation ofC ages,the latter suggesting that rhizoliths formed during the Holocene(~2053 years cal BP,based on root organic relicts). 展开更多
关键词 Rhizoliths CALCIFICATION leptic regosols Artemisia roots Decomposition Soil moisture
在线阅读 下载PDF
非典型抗精神病药治疗少儿双相情感障碍 被引量:4
3
作者 陈宪生 《现代诊断与治疗》 CAS 2007年第5期298-299,共2页
综述了近年来国外应用非典型抗精神病药物治疗儿童及少年双相情感障碍的研究进展。
关键词 非典型精神病药物 双相情感障碍 少童 少年
暂未订购
离子通道与遗传性癫痫 被引量:8
4
作者 孔玮晶 姜玉武 《中国实用儿科杂志》 CSCD 北大核心 2015年第7期481-487,共7页
按照国际抗癫痫联盟(ILAE)的病因学分类,遗传性癫痫是一类由已知或推测的基因缺陷所直接导致的疾病,癫痫发作是其核心症状。目前已发现的参与人类癫痫发病的基因绝大多数是离子通道编码基因,包括电压门控离子通道(钾、钠、钙离子通道亚... 按照国际抗癫痫联盟(ILAE)的病因学分类,遗传性癫痫是一类由已知或推测的基因缺陷所直接导致的疾病,癫痫发作是其核心症状。目前已发现的参与人类癫痫发病的基因绝大多数是离子通道编码基因,包括电压门控离子通道(钾、钠、钙离子通道亚单位等)以及配体门控离子通道[烟碱型乙酰胆碱受体、γ-氨基丁酸(GABA)受体亚单位等]。随着二代测序技术发展,越来越多的离子通道基因突变在不同临床表型谱的癫痫患者中被检测出来,了解离子通道基因缺陷在癫痫致病中的作用,不仅有助于癫痫致病机制的研究,也为癫痫个体化的精准医疗提供依据。 展开更多
关键词 癫痫 遗传性 离子通道 突变 抗癫痫药物
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部