We present and discuss deep high resolution images taken with the ESO NTT as well as spectra taken with the ESO VLT in the field of the BL Lac object PKS 0537 441. We could neither detect the host galaxy nor a galaxy ...We present and discuss deep high resolution images taken with the ESO NTT as well as spectra taken with the ESO VLT in the field of the BL Lac object PKS 0537 441. We could neither detect the host galaxy nor a galaxy along the line of sight to the BL Lac as claimed from previous observations. We found 4 nearby companion galaxies which could be a splitted and magnified image of a distant background galaxy. Our VLT spectra, however, rule out this possibility. All 4 companions have similar redshifts as the BL Lac and may (at least in part) trigger the enormous activity in this source. PKS 0537 441 might be located in a galaxy cluster as rich as Abell 1. Alternatively, the BL Lac could also be located in the outskirts of a galaxy cluster or even be projected on a large scale structure as indicated by spectra of 30 galaxies in the field. Either lensing hypothesis (lens or being lensed) is considerably weakened by our observations.展开更多
From 2011 to 2021,LAMOST has released a total of 76,167 quasar data.We try to search for gravitationally lensed QSOs by limiting coordinate differences and redshift differences of these QSOs.The name,brightness,spectr...From 2011 to 2021,LAMOST has released a total of 76,167 quasar data.We try to search for gravitationally lensed QSOs by limiting coordinate differences and redshift differences of these QSOs.The name,brightness,spectrum,photometry and other information of each QSO will be visually checked carefully.Special attention should be paid to check whether there are groups of galaxies,gravitationally lensed arcs,Einstein crosses,or Einstein rings near the QSOs.Through careful selection,we select LAMOST J160603.01+290050.8(A)and LAMOST J160602.81+290048.7(B)as a candidate and perform an initial analysis.Components A and B are336 apart and they display blue during photometric observations.The redshift values of components A and B are0.2%different,their Gaia_g values are 1.3%different,and their ugriz values are 1.0%or less different.For the spectra covering from 3690 to 9100?,the emission lines of C II,Mg,Hγ,OⅢ,and Hβare present for both components A and B and the ratio of flux(B)to flux(A)from LAMOST is basically a constant,around 2.2.However,no galaxies have been found between components A and B.Inada et al.identified them as binary quasars.But we accidentally find a galaxy group near components A and B.If the center of dark matter in the galaxy group is at the center between components A and B,components A and B are probably gravitationally lensed QSOs.We estimate that the Einstein mass is 1.46×10^(11)M_⊙and the total mass of the lens is1.34×10^(13)M_⊙.The deflection angle is 197 at positions A and B and the velocity dispersion is 261 km s^(-1).Theoretically,this candidate could be a pair of fold images of a strong lensing system by a galaxy group,and we will investigate the possibility when the redshifts of nearby galaxies are available.展开更多
After a brief reminder of the mechanism of gravitational lensing of ex- tended sources, the particular case of the host galaxy of QSO RXJ0911, a high red-shift （z - 2.8） quadruply imaged quasar, is explored. The non...After a brief reminder of the mechanism of gravitational lensing of ex- tended sources, the particular case of the host galaxy of QSO RXJ0911, a high red-shift （z - 2.8） quadruply imaged quasar, is explored. The non linearity of the problem, together with the proximity of the source to a cusp of the lens inner caustic, has impor-tant consequences on the dependence of the image appearance on the size and shape of the source. Their expected main features and their interpretation in terms of source extension and shape are investigated in a spirit of simplicity and in preparation for the analysis of high sensitivity and spatial resolution images that will soon be within reach with the completion of the Atacama Large Millimeter/submillimeter Array （ALMA）. In particular, the information on source size carded by relative image brightness is dis-cussed. Extension of the results to other types of quadruply imaged quasars is briefly considered.展开更多
We study the statistics of large-separation multiply-imaged quasars lensed by clusters of galaxies. In particular, we examine how the observed brightest cluster galaxies （BCGs） affect the predicted numbers of wide-s...We study the statistics of large-separation multiply-imaged quasars lensed by clusters of galaxies. In particular, we examine how the observed brightest cluster galaxies （BCGs） affect the predicted numbers of wide-separation lenses. We model the lens as an NFW-profiled dark matter halo with a truncated singular isothermal sphere to represent the BCG in its center. We mainly make predictions for the Sloan Digital Sky Survey Quasar Lens Search （SQLS） sample from the Data Release 5 （DRS） in two standard ACDM cosmological models： a model with matter density ΩM = 0.3 and δ8 = 0.9, as is usually adopted in the literature （ACDM1）, and a model suggested by the WMAP seven-year （WMAPT） data with ΩM = 0.266 and δ8 = 0.801. We also study the lensing properties for the WMAP3 cosmology in order to compare with the previous work. We find that BCGs in the centers of clusters significantly enhance the lensing efficiency by a factor of 2 - 3 compared with that of NFW-profiled pure dark matter halos. In addition, the dependence of mass ratios of BCGs to their host halos on the host halo masses reduces the lensing rate by - 20% from assuming a constant ratio as in previous studies, but considering the evolution of this ratio with redshift out to z - 1 would reduce it by - 3%. Moreover, we predict that the numbers of lensed quasars with image separations larger than 10″ in the statistical sample of SQLS from DR5 are 1.22 and 0.47, respectively for ACDM1 and WMAP7 and 0.73 and 0.33 for separations between 10″ and 20″, which are consistent with the only observed cluster lens with such a large separation in the complete SQLS sample.展开更多
Strong lensing time delay measurement is a promising method to address the Hubble tension,offering a completely independent approach compared with both the cosmic microwave background analysis and the local distance l...Strong lensing time delay measurement is a promising method to address the Hubble tension,offering a completely independent approach compared with both the cosmic microwave background analysis and the local distance ladder.As a third-party examination of the Hubble tension,this method provides a unique perspective.Strongly lensed quasar(gl QSO)systems have demonstrated significant potential in tackling this issue,achieving an impressive 2%accuracy level.However,advancing to 1%or sub-percent accuracy is challenging due to several intrinsic limitations of gl QSOs.Fortunately,strongly lensed supernovae(gl SNe)offer a more robust solution,thanks to their characteristic light curve,significant brightness variations,and additional advantages.The Muztagh-Ata 1.93 m Synergy Telescope(MOST)is an exceptional instrument for monitoring strong lensing time delays.In this study,we simulate the follow-up multi-band light curve monitoring for gl SNe Ia systems,which are expected to be firstly discovered by the Chinese Survey Space Telescope(CSST).The simulation employs the W7 model,integrating strong lensing and microlensing effects.Our results show that with 300 s×9 exposures in each epoch,2 quadruple-image systems and14 double-image systems are observable by MOST each year.MOST can achieve a signal-to-noise ratio(SNR)of approximately 50 for the brightest images of gl SNe Ia,while even the faintest images maintain an SNR of at least 7.Using a standard SNe Ia light curve template for fitting,we measured the time delays.With a 2-d cadence,MOST achieves a relative time delay error of less than 4.9%,with the bias typically remaining below 0.57%.Finally,we performed a Hubble parameter estimation.For a typical gl SNe Ia system,the H0error is about±1.8 km s^(-1)Mpc^(-1).This result is comparable or even better than those from LSST.This study highlights the capability of MOST to significantly advance the precision of time delay measurements,offering a promising path toward resolving the Hubble tension.展开更多
The Macquart relation and time-delay cosmography are now two promising ways to fast radio burst(FRB)cosmology.In this work,we propose a joint method that combines strongly lensed and unlensed FRBs for improving cosmol...The Macquart relation and time-delay cosmography are now two promising ways to fast radio burst(FRB)cosmology.In this work,we propose a joint method that combines strongly lensed and unlensed FRBs for improving cosmological parameter estimation using simulated FRB data from the future sensitive coherent all-sky monitor survey,which is expected to detect a large number of FRBs including galaxy-galaxy strongly lensed events.We find that using a detectable sample of 100000 localized FRBs including 40 lensed events can simultaneously constrain the Hubble constant and the equation of state of dark energy,with high precision of ε(H_(0))=0.4% and ε(w)=4.5% in the simplest dynamical dark energy model.The joint analysis of unlensed and lensed FRBs significantly improves the constraint on H_(0),which could be more effective than combining either the unlensed FRBs with future gravitational wave(GW)standard sirens or the lensed FRBs with CMB.Furthermore,combining the full FRB sample with the CMB+BAO+SNe data yields σ(H_(0))=0.29 km s^(-1)Mpc^(-1),σ(w_(0))=0.046,and σ(w_(a))=0.15 in the two-parameter dynamical dark energy model,which outperforms the results from the CMB+BAO+SNe+GW data.This reinforces the cosmological implications of a multi-wavelength observational strategy in optical and radio bands.We conclude that the future FRB observations will shed light on the nature of dark energy and also the Hubble tension if enough events with long-duration lensing are incorporated.展开更多
The Hubble constant H0,a key parameter quantifying the present expansion rate of the universe,remains a subject of significant debate due to the persistent tension between early-and late-universe measurements.Strong g...The Hubble constant H0,a key parameter quantifying the present expansion rate of the universe,remains a subject of significant debate due to the persistent tension between early-and late-universe measurements.Strong gravitational lensing(SGL) time delays provide an independent avenue to constrain H0.In this paper,we utilize seven SGL systems from the TDCOSMO sample to constrain H_(0),employing the model-independent approaches:deep neural networks(DNN),Gaussian process(GP),polynomial fitting(polyfit) and Padé approximant(PA).Using these methods,we reconstruct unanchored luminosity distances from the Pantheon+SNe Ia dataset and obtain H_(0)=72.3_(-3.6)^(+3.8)km s^(-1)Mpc^(-1),H_(0)=72.4_(-1.7)^(+1.6)km s^(-1)Mpc^(-1),H0=70.7_(-3.1)^(+3.0)km s^(-1)Mpc^(-1)and H0=74.0_(-2.7)^(+2.7)km s^(-1)Mpc^(-1),respectively.These estimates are consistent within 1σ level and align with local distance ladder results.Notably,the GP method achieves uncertainties that are half those of the DNN approach,whereas the DNN method offers more reliable confidence intervals in reconstruction at high redshifts.Our findings underscore the potential of these methodologies to refine constraints on H_(0) and contribute to resolving the Hubble tension with future advancements.展开更多
A novel fabrication method for lensed fiber array has been proposed utilizing UV-curable fluorinated polymer, whose refractive index is matched to fused silica. The structure is composed of three segments; single mode...A novel fabrication method for lensed fiber array has been proposed utilizing UV-curable fluorinated polymer, whose refractive index is matched to fused silica. The structure is composed of three segments; single mode fiber, coreless silica fiber and UV-curable polymer lens-tip. Flexible control of the curvature of lens-tip was realized by control of deposited volume of the liquid polymer and free-space interconnection performances are characterized.展开更多
AIM:To compare the visual outcomes between bilateral implantation of Tecnis ZXR00 extended depth-of-focus(EDOF)intraocular lenses(IOLs)and mixed implantation of Tecnis ZXR00(EDOF)with Tecnis ZMB00(bifocal)IOLs.METHODS...AIM:To compare the visual outcomes between bilateral implantation of Tecnis ZXR00 extended depth-of-focus(EDOF)intraocular lenses(IOLs)and mixed implantation of Tecnis ZXR00(EDOF)with Tecnis ZMB00(bifocal)IOLs.METHODS:This postoperative cross-sectional study enrolled patients who underwent phacoemulsification combined with IOL implantation.Patients were divided into two groups:the bilateral ZXR00 group(ZXR00-only group)and the mixed IOL group(ZXR00+ZMB00 group).Primary outcome measures included uncorrected and corrected distance visual acuity(UDVA,CDVA),uncorrected and distance-corrected near visual acuity(UNVA,DCNVA),uncorrected and distance-corrected intermediate visual acuity(UIVA,DCIVA),and defocus curves.Secondary outcome measures were visual quality,spectacle independence,patient satisfaction,photic phenomena,and stereopsis.RESULTS:A total of 47 patients(94 eyes)were included,with 26 patients(11 males,15 females)in the ZXR00-only group(mean age:62.73±7.24y)and 21 patients(7 males,14 females)in the mixed group(mean age:65.71±9.16y).There was no statistically significant difference in age between the two groups(P=0.218).The mixed group showed significantly better binocular DCNVA compared to the ZXR00-only group(P=0.002).Defocus curve analysis revealed that the mixed group exhibited superior performance at−2.5 to−4.0 D but inferior performance at−0.5 and−1.5 D.Near stereoacuity was significantly poorer in the mixed group(Randot:5.589±0.744 vs 6.240±0.394 ln arcsec;Contour:4.966±0.973 vs 5.740±0.833 ln arcsec;both P<0.01).Both groups achieved high levels of spectacle independence and patient satisfaction,with no significant differences in photic phenomena or questionnaire scores.CONCLUSION:Mixed implantation of EDOF and bifocal IOLs improve near visual acuity but may compromise near stereopsis.This approach provides a viable option for patients prioritizing near vision;however,caution is recommended for individuals requiring fine stereoscopic vision for daily or professional tasks.展开更多
MXene-based smart contact lenses demonstrate a cutting-edge advancement in wearable ophthalmic technology,combining real-time biosensing,therapeutic capabilities,and user comfort in a single platform.These devices tak...MXene-based smart contact lenses demonstrate a cutting-edge advancement in wearable ophthalmic technology,combining real-time biosensing,therapeutic capabilities,and user comfort in a single platform.These devices take the advantage of the exceptional electrical conductivity,mechanical flexibility,and biocompatibility of two-dimensional MXenes to enable noninvasive,tear-based monitoring of key physiological markers such as intraocular pressure and glucose levels.Recent developments focus on the integration of transparent MXene films into the conventional lens materials,allowing multifunctional performance including photothermal therapy,antimicrobial and anti-inflammation protection,and dehydration resistance.These innovations offer promising strategies for ocular disease management and eye protection.In addition to their multifunctionality,improvements in MXene synthesis and device engineering have enhanced the stability,transparency,and wearability of these lenses.Despite these advances,challenges remain in long-term biostability,scalable production,and integration with wireless communication systems.This review summarizes the current progress,key challenges,and future directions of MXene-based smart contact lenses,highlighting their transformative potential in next-generation digital healthcare and ophthalmic care.展开更多
AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 group...AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.展开更多
AIM:To investigate age-related differences in the irislens angle(ILA)among patients with age-related cortical cataracts and elucidate the impact of age on lens stability.METHODS:A prospective observational study was c...AIM:To investigate age-related differences in the irislens angle(ILA)among patients with age-related cortical cataracts and elucidate the impact of age on lens stability.METHODS:A prospective observational study was conducted on patients with age-related cortical cataracts scheduled for phacoemulsification surgery.Preoperative ultrasound biomicroscopy(UBM)images were collected and analyzed.Initially,patients were stratified into two age groups:<60y and≥60y,with no significant intergroup differences in sex or eye laterality.For further analysis,participants were subdivided into three age strata:<60y,60-75y,and>75y.The ILA was measured in four quadrants(superior,inferior,nasal,and temporal).Intergroup differences in ILA were compared,and correlations between age and ILA parameters were analyzed using statistical methods.RESULTS:The sample data were categorized into three groups according to age,<60y(113 patients;55.8%female),60–75y(245 patients;61.0%female),and>75y(70 patients;50.2%female).The superior quadrant ILA increased progressively with age stratification(P=0.02),and the maximum ILA difference(ΔILA)was significantly higher in patients over 75y(P<0.01).Simple linear regression analysis demonstrated a positive correlation between age and ILA in the superior(Y=7.487+0.096X,R=0.191,P<0.001)and temporal(Y=10.254+0.052X,R=0.104,P=0.032)quadrants.Additionally,the mean ILA across all quadrants(ILAmean)andΔILA were positively correlated with age(ILAmean:Y=9.721+0.055X,R=0.138,P=0.004;ΔILA:Y=3.267+0.044X,R=0.006,P<0.05).CONCLUSION:In patients with age-related cortical cataracts,ILA increases with age,particularly in the superior and temporal quadrants,suggesting that advanced age is associated with greater lens deviation and decreased lens stability.UBM imaging can effectively evaluate the status of the zonule and lens stability,providing crucial evidence for personalized surgical planning based on patients’age.展开更多
AIM:To investigate the long-term outcomes in acute primary angle closure(APAC)patients treated with lens extraction(LE)surgery and to identify risk factors for glaucomatous optic neuropathy(GON).METHODS:In this longit...AIM:To investigate the long-term outcomes in acute primary angle closure(APAC)patients treated with lens extraction(LE)surgery and to identify risk factors for glaucomatous optic neuropathy(GON).METHODS:In this longitudinal observational study,detailed medical histories of APAC patients and comprehensive ophthalmic examinations at final followup were collected.Logistic regression analysis was performed to identify predictors of blindness.Univariate and multivariate linear regression analyses were conducted to determine risk factors associated with visual outcomes.RESULTS:This study included 39 affected eyes of 31 subjects(26 females)with an average age of 74.1±8.0y.At 6.7±4.2y after APAC attack,2(5.7%)eyes had bestcorrected visual acuity(VA)worse than 3/60.Advanced glaucomatous visual field loss was observed in 15(39.5%)affected eyes and 5(25.0%)fellow eyes.Nine affected eyes(23.7%)had GON,and 11(28.9%)were blind.Six(15.4%)affected eyes and 2(9.1%)fellow eyes had suspicious progression.A significantly higher blindness rate in factory workers compared to office workers.Logistic regression identified that worse VA at attack(OR 10.568,95%CI 1.288-86.695;P=0.028)and worse early postoperative VA(OR 13.214,95%CI 1.157-150.881;P=0.038)were risk factors for blindness.Multivariate regression showed that longer duration of elevated intraocular pressure(P=0.004)and worse early postoperative VA(P=0.009)were associated with worse visual outcomes.CONCLUSION:Despite LE surgery,some APAC patients experience continued visual function deterioration.Lifelong monitoring is necessary.Target pressure and progression rates should be re-evaluated during follow-up.展开更多
The cosmic distance relation(DDR) associates the angular diameters distance(DA) and luminosity distance(DL) by a simple formula,i.e.,DL=(1+z)2 DA.The strongly lensed gravitational waves(GWs) provide a unique way to me...The cosmic distance relation(DDR) associates the angular diameters distance(DA) and luminosity distance(DL) by a simple formula,i.e.,DL=(1+z)2 DA.The strongly lensed gravitational waves(GWs) provide a unique way to measure DA and DL simultaneously to the GW source,hence they can be used as probes to test DDR.In this study,we investigated the use of strongly lensed GW events from the future Einstein Telescope to test DDR.We assumed the possible deviation of DDR as(1+z)2 DA/DL=η(z),and considered two different parametrizations of η(z),namely,η1(z)=1+η0 z and η2(z)=1+η0 z/(1+z).Numerical simulations showed that,with about 100 strongly lensed GW events observed by ET,the parameter η0 was constrained at 1.3% and 3% levels for the first and second parametrizations,respectively.展开更多
We propose a new method to test the cosmic distance duality relation using the strongly lensed gravitational waves.The simultaneous observation of the image positions,relative time delay between different images,redsh...We propose a new method to test the cosmic distance duality relation using the strongly lensed gravitational waves.The simultaneous observation of the image positions,relative time delay between different images,redshift measurements of the lens and the source,together with the mass modelling of the lens galaxy,provide the angular diameter distance to the gravitational wave source.On the other hand,the luminosity distance to the source can be obtained from the observation of the gravitational wave signals.To our knowledge this is the first time a method is proposed to simultaneously measure the angular diameter distance and the luminosity distance from the same source.Hence,the strongly lensed gravitational waves provide a unique method to test the cosmic distance duality relation.With the construction of the third generation gravitational detectors such as the Einstein Telescope,it will be possible to test the cosmic distance duality relation with an accuracy of a few percent.展开更多
The possible variation of the electromagnetic fine structure constant, αe, at cosmological scales has aroused great interest in recent years. Strongly lensed gravitational waves（GWs） and their electromagnetic count...The possible variation of the electromagnetic fine structure constant, αe, at cosmological scales has aroused great interest in recent years. Strongly lensed gravitational waves（GWs） and their electromagnetic counterparts could be used to test this variation. Under the assumption that the speed of a photon can be modified,whereas the speed of a GW is the same as predicted by general relativity, and they both propagate in a flat FriedmanRobertson-Walker universe, we investigated the difference in time delays of the images and derived the upper bound of the variation of αe. For a typical lensing system in the standard cosmological models, we obtained B cosθ 1.85×10^（-5）,where B is the dipolar amplitude and θ is the angle between observation and the preferred direction. Our result is consistent with the most up-to-date observations on αe. In addition, the observations of strongly lensed GWs and their electromagnetic counterparts could be used to test which types of alternative theories of gravity can account for the variation of α_e.展开更多
The immune system is involved in many age-related pathological changes,also plays an important role in tissue regeneration after injury.But no immune involvement has been discussed regarding cataract since it is presu...The immune system is involved in many age-related pathological changes,also plays an important role in tissue regeneration after injury.But no immune involvement has been discussed regarding cataract since it is presumed that lens has no source of immune cells as an avascular zone.Latest research has challenged the longstanding view of the lens as an immune-privileged tissue,revealing the presence of resident immune cells and active immune responses within the lens.Thus,we summarized the immune involvement in maintaining lens homeostasis,which may be a deleterious role in the induction of lens opacification if inappropriately activated.Furthermore,bioengineer-based immunomodulatory therapies to fine-tune the micro immune environment within lens may be future strategies for in situ lens regeneration,as a novel treatment for cataract.展开更多
AIM:To compare the clinical outcomes of extended depth-of-focus intraocular lenses(EDOF IOLs)using either micromonovision implantation or mixed implantation of EDOF and diffractive bifocal IOLs.METHODS:This retrospect...AIM:To compare the clinical outcomes of extended depth-of-focus intraocular lenses(EDOF IOLs)using either micromonovision implantation or mixed implantation of EDOF and diffractive bifocal IOLs.METHODS:This retrospective clinical trial included 130 patients(260 eyes),who were divided into two groups.Group RR comprised 70 patients(140 eyes)bilaterally implanted with ZXR00 IOLs(Tecnis ZXR00,where one target was-0.5 D to-0.75 D and the other was 0 to-0.25 D).Group RM comprised 60 patients(120 eyes)unilaterally implanted with both ZXR00 and ZMB00 IOLs(Tecnis ZMB00,0 to-0.25 D).Postoperative outcomes were compared after 3 mo,including visual acuity,defocus curves,stereoacuity,modulation transfer functions(MTFs),higher-order aberrations,and Visual Function-14(VF-14)questionnaire responses.RESULTS:Group RR had superior bilateral intermediate vision,while the group RM had superior bilateral near vision(both P<0.05).Group RM also exhibited superior MTFs and reduced higher-order aberrations(both P<0.05).Stereoacuity and VF-14 questionnaire results showed no statistically significant difference between groups(P>0.05).CONCLUSION:The implantation of micromonovision has significantly improved near vision.IOLs and their collocation can be customized according to individual patient needs to achieve precise treatment and provide cataract patients with high-quality vision.展开更多
Objective To compare the efficacy of toric implantable collamer lens(Toric-ICL)and femtosecond laser-assisted in situ keratomileusis(FS-LASIK)for myopia correction in patients with moderate to high myopia complicated ...Objective To compare the efficacy of toric implantable collamer lens(Toric-ICL)and femtosecond laser-assisted in situ keratomileusis(FS-LASIK)for myopia correction in patients with moderate to high myopia complicated with astigmatism.Methods We retrospectively collected data from 64 patients(aged 18-42 years)with moderate to high myopia complicated with astigmatism(128 eyes)undergoing either Toric-ICL(28 patients/56 eyes)or FS-LASIK(36 patients/72 eyes)at our department between January,2019 and December,2020.The changes of uncorrected distance visual acuity(UCVA),spherical equivalent(SE),mean astigmatism correction index(CI),corneal endothelial cell density(ECD)and intraocular pressure(IOP)following the procedures were compared between the two groups.Results In FS-LASIK group,all the eyes(72/72)achieved an UCVA≥1.0,similar to the rate in Toric-ICL group(55/56 eyes;P=0.2374).The postoperative SE was also comparable between FS-LASIK and Toric-ICL groups[0.43±0.06 D(range:-1.0 to 1.50 D)vs 0.38±0.05 D(range:-0.75 to 1.00 D);P=0.56].The mean astigmatism CI was significantly higher in FS-LASIK group than in Toric-ICL group(0.8561 vs 0.7176;P<0.0001),and 88.89%of the eyes in FS-LASIK group and 69.64%in Toric-ICL group had postoperative astigmatism≤0.50 D.No significant changes were observed in postoperative corneal ECD in FS-LASIK group,whereas ECD decreased significantly after the procedure in Toric-ICL group(P=0.0057).The patients undergoing Toric-ICL exhibited no significant changes of postoperative IOP,but the patients receiving FS-LASIK had significantly reduced IOP after the procedure(P<0.001).Conclusion Although the patients included in Toric-ICL group had higher myopia and astigmatism,Toric-ICL still showed better predictability and efficacy for astigmatic correction in Toric-ICL group.Toric-ICL is an effective and safe equivalent of FS-LASIK for correcting moderate myopia but can be more advantageous for correcting high myopia with astigmatism.展开更多
Objective:To evaluate the performance of orthokeratology(ortho-k)lens reordering using software-designed system,so as to determine the feasibility of ortho-k lens reordering without discontinuing lens wear.Methods:Thi...Objective:To evaluate the performance of orthokeratology(ortho-k)lens reordering using software-designed system,so as to determine the feasibility of ortho-k lens reordering without discontinuing lens wear.Methods:This study is a retrospective analysis of data of ortho-k lens wearers who had a history of short-term discontinuation of lens wear.A total of 94 individuals aged over 8 years with spherical equivalent refraction ranging from-0.50 to-6.50 diopters were included.The corneal topography data at baseline(before ortho-k)and after lens wear discontinuation(cessation of ortho-k treatment)were imported separately into the lens-design software,along with corresponding refraction data.Subsequently,corneal and lens parameters were generated and compared.Intraclass correlation coefficients(ICC)were calculated,and Bland and Altman analyses were conducted.Results:All 94 children were involved in the retrospective analysis.Compared with baseline data,there was a high level of consistency between Rwo(without discontinuation)and Rwith(with discontinuation),with an ICC of 0.96(P<0.001).Furthermore,the comparison of lens parameters generated by the Easyfit software between baseline and after short-term discontinuation showed a high degree of consistency,with all of the ICC values exceeding 0.90.Similar results were obtained using the WAVE software,as both ICC values and Bland-Altman plots demonstrated a high level of consistency in lens parameters between two conditions(nearly all data points fell within the 95%LoAs).Conclusions:It is feasible to directly reorder new ortho-k lenses using software fitting approaches.However,further investigations are necessary to validate their practicability in a clinical setting.展开更多
文摘We present and discuss deep high resolution images taken with the ESO NTT as well as spectra taken with the ESO VLT in the field of the BL Lac object PKS 0537 441. We could neither detect the host galaxy nor a galaxy along the line of sight to the BL Lac as claimed from previous observations. We found 4 nearby companion galaxies which could be a splitted and magnified image of a distant background galaxy. Our VLT spectra, however, rule out this possibility. All 4 companions have similar redshifts as the BL Lac and may (at least in part) trigger the enormous activity in this source. PKS 0537 441 might be located in a galaxy cluster as rich as Abell 1. Alternatively, the BL Lac could also be located in the outskirts of a galaxy cluster or even be projected on a large scale structure as indicated by spectra of 30 galaxies in the field. Either lensing hypothesis (lens or being lensed) is considerably weakened by our observations.
基金provided by the National Development and Reform Commissionthe support of the National Natural Science Foundation of China(NSFC,11803004)+2 种基金Yunnan Province Youth Talent Project(2019182)the support by NSFC through grant No.12203011Yunnan provincial Department of Science and Technology through grant No.202101BA070001-261。
文摘From 2011 to 2021,LAMOST has released a total of 76,167 quasar data.We try to search for gravitationally lensed QSOs by limiting coordinate differences and redshift differences of these QSOs.The name,brightness,spectrum,photometry and other information of each QSO will be visually checked carefully.Special attention should be paid to check whether there are groups of galaxies,gravitationally lensed arcs,Einstein crosses,or Einstein rings near the QSOs.Through careful selection,we select LAMOST J160603.01+290050.8(A)and LAMOST J160602.81+290048.7(B)as a candidate and perform an initial analysis.Components A and B are336 apart and they display blue during photometric observations.The redshift values of components A and B are0.2%different,their Gaia_g values are 1.3%different,and their ugriz values are 1.0%or less different.For the spectra covering from 3690 to 9100?,the emission lines of C II,Mg,Hγ,OⅢ,and Hβare present for both components A and B and the ratio of flux(B)to flux(A)from LAMOST is basically a constant,around 2.2.However,no galaxies have been found between components A and B.Inada et al.identified them as binary quasars.But we accidentally find a galaxy group near components A and B.If the center of dark matter in the galaxy group is at the center between components A and B,components A and B are probably gravitationally lensed QSOs.We estimate that the Einstein mass is 1.46×10^(11)M_⊙and the total mass of the lens is1.34×10^(13)M_⊙.The deflection angle is 197 at positions A and B and the velocity dispersion is 261 km s^(-1).Theoretically,this candidate could be a pair of fold images of a strong lensing system by a galaxy group,and we will investigate the possibility when the redshifts of nearby galaxies are available.
基金support from the Institute for Nuclear Science and Technology, National Foundation for Science and Technology Development (NAFOSTED)the World Laboratory, the French CNRS, the French Embassy in Hanoi, Rencontres du Vietnam and Odon Vallet fellowships
文摘After a brief reminder of the mechanism of gravitational lensing of ex- tended sources, the particular case of the host galaxy of QSO RXJ0911, a high red-shift （z - 2.8） quadruply imaged quasar, is explored. The non linearity of the problem, together with the proximity of the source to a cusp of the lens inner caustic, has impor-tant consequences on the dependence of the image appearance on the size and shape of the source. Their expected main features and their interpretation in terms of source extension and shape are investigated in a spirit of simplicity and in preparation for the analysis of high sensitivity and spatial resolution images that will soon be within reach with the completion of the Atacama Large Millimeter/submillimeter Array （ALMA）. In particular, the information on source size carded by relative image brightness is dis-cussed. Extension of the results to other types of quadruply imaged quasars is briefly considered.
基金supported by the National Natural Science Foundation of China(Grant No. 11073023)the National Basic Research Program of China (973 ProgramGrant No.2009CB24901)
文摘We study the statistics of large-separation multiply-imaged quasars lensed by clusters of galaxies. In particular, we examine how the observed brightest cluster galaxies （BCGs） affect the predicted numbers of wide-separation lenses. We model the lens as an NFW-profiled dark matter halo with a truncated singular isothermal sphere to represent the BCG in its center. We mainly make predictions for the Sloan Digital Sky Survey Quasar Lens Search （SQLS） sample from the Data Release 5 （DRS） in two standard ACDM cosmological models： a model with matter density ΩM = 0.3 and δ8 = 0.9, as is usually adopted in the literature （ACDM1）, and a model suggested by the WMAP seven-year （WMAPT） data with ΩM = 0.266 and δ8 = 0.801. We also study the lensing properties for the WMAP3 cosmology in order to compare with the previous work. We find that BCGs in the centers of clusters significantly enhance the lensing efficiency by a factor of 2 - 3 compared with that of NFW-profiled pure dark matter halos. In addition, the dependence of mass ratios of BCGs to their host halos on the host halo masses reduces the lensing rate by - 20% from assuming a constant ratio as in previous studies, but considering the evolution of this ratio with redshift out to z - 1 would reduce it by - 3%. Moreover, we predict that the numbers of lensed quasars with image separations larger than 10″ in the statistical sample of SQLS from DR5 are 1.22 and 0.47, respectively for ACDM1 and WMAP7 and 0.73 and 0.33 for separations between 10″ and 20″, which are consistent with the only observed cluster lens with such a large separation in the complete SQLS sample.
基金supported by the National Natural Science Foundation of China(Grant Nos.12333001,61234003,61434004,and 61504141)the CAS Interdisciplinary Project(Grant No.KJZD-EW-L11-04)+1 种基金support from the China Postdoctoral Science Foundation(Grant No.GZC20232990)the National Natural Science Foundation of China(Grant No.12403104)。
文摘Strong lensing time delay measurement is a promising method to address the Hubble tension,offering a completely independent approach compared with both the cosmic microwave background analysis and the local distance ladder.As a third-party examination of the Hubble tension,this method provides a unique perspective.Strongly lensed quasar(gl QSO)systems have demonstrated significant potential in tackling this issue,achieving an impressive 2%accuracy level.However,advancing to 1%or sub-percent accuracy is challenging due to several intrinsic limitations of gl QSOs.Fortunately,strongly lensed supernovae(gl SNe)offer a more robust solution,thanks to their characteristic light curve,significant brightness variations,and additional advantages.The Muztagh-Ata 1.93 m Synergy Telescope(MOST)is an exceptional instrument for monitoring strong lensing time delays.In this study,we simulate the follow-up multi-band light curve monitoring for gl SNe Ia systems,which are expected to be firstly discovered by the Chinese Survey Space Telescope(CSST).The simulation employs the W7 model,integrating strong lensing and microlensing effects.Our results show that with 300 s×9 exposures in each epoch,2 quadruple-image systems and14 double-image systems are observable by MOST each year.MOST can achieve a signal-to-noise ratio(SNR)of approximately 50 for the brightest images of gl SNe Ia,while even the faintest images maintain an SNR of at least 7.Using a standard SNe Ia light curve template for fitting,we measured the time delays.With a 2-d cadence,MOST achieves a relative time delay error of less than 4.9%,with the bias typically remaining below 0.57%.Finally,we performed a Hubble parameter estimation.For a typical gl SNe Ia system,the H0error is about±1.8 km s^(-1)Mpc^(-1).This result is comparable or even better than those from LSST.This study highlights the capability of MOST to significantly advance the precision of time delay measurements,offering a promising path toward resolving the Hubble tension.
基金supported by the National SKA Program of China(Grant Nos.2022SKA0110200,and 2022SKA0110203)the National Natural Science Foundation of China(Grant Nos.12473001,11975072,11835009,and 11875102)the National 111 Project(Grant No.B16009)。
文摘The Macquart relation and time-delay cosmography are now two promising ways to fast radio burst(FRB)cosmology.In this work,we propose a joint method that combines strongly lensed and unlensed FRBs for improving cosmological parameter estimation using simulated FRB data from the future sensitive coherent all-sky monitor survey,which is expected to detect a large number of FRBs including galaxy-galaxy strongly lensed events.We find that using a detectable sample of 100000 localized FRBs including 40 lensed events can simultaneously constrain the Hubble constant and the equation of state of dark energy,with high precision of ε(H_(0))=0.4% and ε(w)=4.5% in the simplest dynamical dark energy model.The joint analysis of unlensed and lensed FRBs significantly improves the constraint on H_(0),which could be more effective than combining either the unlensed FRBs with future gravitational wave(GW)standard sirens or the lensed FRBs with CMB.Furthermore,combining the full FRB sample with the CMB+BAO+SNe data yields σ(H_(0))=0.29 km s^(-1)Mpc^(-1),σ(w_(0))=0.046,and σ(w_(a))=0.15 in the two-parameter dynamical dark energy model,which outperforms the results from the CMB+BAO+SNe+GW data.This reinforces the cosmological implications of a multi-wavelength observational strategy in optical and radio bands.We conclude that the future FRB observations will shed light on the nature of dark energy and also the Hubble tension if enough events with long-duration lensing are incorporated.
文摘The Hubble constant H0,a key parameter quantifying the present expansion rate of the universe,remains a subject of significant debate due to the persistent tension between early-and late-universe measurements.Strong gravitational lensing(SGL) time delays provide an independent avenue to constrain H0.In this paper,we utilize seven SGL systems from the TDCOSMO sample to constrain H_(0),employing the model-independent approaches:deep neural networks(DNN),Gaussian process(GP),polynomial fitting(polyfit) and Padé approximant(PA).Using these methods,we reconstruct unanchored luminosity distances from the Pantheon+SNe Ia dataset and obtain H_(0)=72.3_(-3.6)^(+3.8)km s^(-1)Mpc^(-1),H_(0)=72.4_(-1.7)^(+1.6)km s^(-1)Mpc^(-1),H0=70.7_(-3.1)^(+3.0)km s^(-1)Mpc^(-1)and H0=74.0_(-2.7)^(+2.7)km s^(-1)Mpc^(-1),respectively.These estimates are consistent within 1σ level and align with local distance ladder results.Notably,the GP method achieves uncertainties that are half those of the DNN approach,whereas the DNN method offers more reliable confidence intervals in reconstruction at high redshifts.Our findings underscore the potential of these methodologies to refine constraints on H_(0) and contribute to resolving the Hubble tension with future advancements.
文摘A novel fabrication method for lensed fiber array has been proposed utilizing UV-curable fluorinated polymer, whose refractive index is matched to fused silica. The structure is composed of three segments; single mode fiber, coreless silica fiber and UV-curable polymer lens-tip. Flexible control of the curvature of lens-tip was realized by control of deposited volume of the liquid polymer and free-space interconnection performances are characterized.
文摘AIM:To compare the visual outcomes between bilateral implantation of Tecnis ZXR00 extended depth-of-focus(EDOF)intraocular lenses(IOLs)and mixed implantation of Tecnis ZXR00(EDOF)with Tecnis ZMB00(bifocal)IOLs.METHODS:This postoperative cross-sectional study enrolled patients who underwent phacoemulsification combined with IOL implantation.Patients were divided into two groups:the bilateral ZXR00 group(ZXR00-only group)and the mixed IOL group(ZXR00+ZMB00 group).Primary outcome measures included uncorrected and corrected distance visual acuity(UDVA,CDVA),uncorrected and distance-corrected near visual acuity(UNVA,DCNVA),uncorrected and distance-corrected intermediate visual acuity(UIVA,DCIVA),and defocus curves.Secondary outcome measures were visual quality,spectacle independence,patient satisfaction,photic phenomena,and stereopsis.RESULTS:A total of 47 patients(94 eyes)were included,with 26 patients(11 males,15 females)in the ZXR00-only group(mean age:62.73±7.24y)and 21 patients(7 males,14 females)in the mixed group(mean age:65.71±9.16y).There was no statistically significant difference in age between the two groups(P=0.218).The mixed group showed significantly better binocular DCNVA compared to the ZXR00-only group(P=0.002).Defocus curve analysis revealed that the mixed group exhibited superior performance at−2.5 to−4.0 D but inferior performance at−0.5 and−1.5 D.Near stereoacuity was significantly poorer in the mixed group(Randot:5.589±0.744 vs 6.240±0.394 ln arcsec;Contour:4.966±0.973 vs 5.740±0.833 ln arcsec;both P<0.01).Both groups achieved high levels of spectacle independence and patient satisfaction,with no significant differences in photic phenomena or questionnaire scores.CONCLUSION:Mixed implantation of EDOF and bifocal IOLs improve near visual acuity but may compromise near stereopsis.This approach provides a viable option for patients prioritizing near vision;however,caution is recommended for individuals requiring fine stereoscopic vision for daily or professional tasks.
文摘MXene-based smart contact lenses demonstrate a cutting-edge advancement in wearable ophthalmic technology,combining real-time biosensing,therapeutic capabilities,and user comfort in a single platform.These devices take the advantage of the exceptional electrical conductivity,mechanical flexibility,and biocompatibility of two-dimensional MXenes to enable noninvasive,tear-based monitoring of key physiological markers such as intraocular pressure and glucose levels.Recent developments focus on the integration of transparent MXene films into the conventional lens materials,allowing multifunctional performance including photothermal therapy,antimicrobial and anti-inflammation protection,and dehydration resistance.These innovations offer promising strategies for ocular disease management and eye protection.In addition to their multifunctionality,improvements in MXene synthesis and device engineering have enhanced the stability,transparency,and wearability of these lenses.Despite these advances,challenges remain in long-term biostability,scalable production,and integration with wireless communication systems.This review summarizes the current progress,key challenges,and future directions of MXene-based smart contact lenses,highlighting their transformative potential in next-generation digital healthcare and ophthalmic care.
基金Supported by the Zhejiang Medical Health Science and Technology Project(No.2021KY217)the Basic Public Welfare Research Project of Wenzhou Municipal Science and Technology Bureau(No.2024Y1221).
文摘AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.
文摘AIM:To investigate age-related differences in the irislens angle(ILA)among patients with age-related cortical cataracts and elucidate the impact of age on lens stability.METHODS:A prospective observational study was conducted on patients with age-related cortical cataracts scheduled for phacoemulsification surgery.Preoperative ultrasound biomicroscopy(UBM)images were collected and analyzed.Initially,patients were stratified into two age groups:<60y and≥60y,with no significant intergroup differences in sex or eye laterality.For further analysis,participants were subdivided into three age strata:<60y,60-75y,and>75y.The ILA was measured in four quadrants(superior,inferior,nasal,and temporal).Intergroup differences in ILA were compared,and correlations between age and ILA parameters were analyzed using statistical methods.RESULTS:The sample data were categorized into three groups according to age,<60y(113 patients;55.8%female),60–75y(245 patients;61.0%female),and>75y(70 patients;50.2%female).The superior quadrant ILA increased progressively with age stratification(P=0.02),and the maximum ILA difference(ΔILA)was significantly higher in patients over 75y(P<0.01).Simple linear regression analysis demonstrated a positive correlation between age and ILA in the superior(Y=7.487+0.096X,R=0.191,P<0.001)and temporal(Y=10.254+0.052X,R=0.104,P=0.032)quadrants.Additionally,the mean ILA across all quadrants(ILAmean)andΔILA were positively correlated with age(ILAmean:Y=9.721+0.055X,R=0.138,P=0.004;ΔILA:Y=3.267+0.044X,R=0.006,P<0.05).CONCLUSION:In patients with age-related cortical cataracts,ILA increases with age,particularly in the superior and temporal quadrants,suggesting that advanced age is associated with greater lens deviation and decreased lens stability.UBM imaging can effectively evaluate the status of the zonule and lens stability,providing crucial evidence for personalized surgical planning based on patients’age.
文摘AIM:To investigate the long-term outcomes in acute primary angle closure(APAC)patients treated with lens extraction(LE)surgery and to identify risk factors for glaucomatous optic neuropathy(GON).METHODS:In this longitudinal observational study,detailed medical histories of APAC patients and comprehensive ophthalmic examinations at final followup were collected.Logistic regression analysis was performed to identify predictors of blindness.Univariate and multivariate linear regression analyses were conducted to determine risk factors associated with visual outcomes.RESULTS:This study included 39 affected eyes of 31 subjects(26 females)with an average age of 74.1±8.0y.At 6.7±4.2y after APAC attack,2(5.7%)eyes had bestcorrected visual acuity(VA)worse than 3/60.Advanced glaucomatous visual field loss was observed in 15(39.5%)affected eyes and 5(25.0%)fellow eyes.Nine affected eyes(23.7%)had GON,and 11(28.9%)were blind.Six(15.4%)affected eyes and 2(9.1%)fellow eyes had suspicious progression.A significantly higher blindness rate in factory workers compared to office workers.Logistic regression identified that worse VA at attack(OR 10.568,95%CI 1.288-86.695;P=0.028)and worse early postoperative VA(OR 13.214,95%CI 1.157-150.881;P=0.038)were risk factors for blindness.Multivariate regression showed that longer duration of elevated intraocular pressure(P=0.004)and worse early postoperative VA(P=0.009)were associated with worse visual outcomes.CONCLUSION:Despite LE surgery,some APAC patients experience continued visual function deterioration.Lifelong monitoring is necessary.Target pressure and progression rates should be re-evaluated during follow-up.
基金Supported by the National Natural Science Fund of China(11603005,11775038,11947406)。
文摘The cosmic distance relation(DDR) associates the angular diameters distance(DA) and luminosity distance(DL) by a simple formula,i.e.,DL=(1+z)2 DA.The strongly lensed gravitational waves(GWs) provide a unique way to measure DA and DL simultaneously to the GW source,hence they can be used as probes to test DDR.In this study,we investigated the use of strongly lensed GW events from the future Einstein Telescope to test DDR.We assumed the possible deviation of DDR as(1+z)2 DA/DL=η(z),and considered two different parametrizations of η(z),namely,η1(z)=1+η0 z and η2(z)=1+η0 z/(1+z).Numerical simulations showed that,with about 100 strongly lensed GW events observed by ET,the parameter η0 was constrained at 1.3% and 3% levels for the first and second parametrizations,respectively.
基金Supported by the National Natural Science Fund of China(11603005 and 11775038)。
文摘We propose a new method to test the cosmic distance duality relation using the strongly lensed gravitational waves.The simultaneous observation of the image positions,relative time delay between different images,redshift measurements of the lens and the source,together with the mass modelling of the lens galaxy,provide the angular diameter distance to the gravitational wave source.On the other hand,the luminosity distance to the source can be obtained from the observation of the gravitational wave signals.To our knowledge this is the first time a method is proposed to simultaneously measure the angular diameter distance and the luminosity distance from the same source.Hence,the strongly lensed gravitational waves provide a unique method to test the cosmic distance duality relation.With the construction of the third generation gravitational detectors such as the Einstein Telescope,it will be possible to test the cosmic distance duality relation with an accuracy of a few percent.
基金Supported by the National Natural Science Fund of China(11775038,11603005,11647307)
文摘The possible variation of the electromagnetic fine structure constant, αe, at cosmological scales has aroused great interest in recent years. Strongly lensed gravitational waves（GWs） and their electromagnetic counterparts could be used to test this variation. Under the assumption that the speed of a photon can be modified,whereas the speed of a GW is the same as predicted by general relativity, and they both propagate in a flat FriedmanRobertson-Walker universe, we investigated the difference in time delays of the images and derived the upper bound of the variation of αe. For a typical lensing system in the standard cosmological models, we obtained B cosθ 1.85×10^（-5）,where B is the dipolar amplitude and θ is the angle between observation and the preferred direction. Our result is consistent with the most up-to-date observations on αe. In addition, the observations of strongly lensed GWs and their electromagnetic counterparts could be used to test which types of alternative theories of gravity can account for the variation of α_e.
基金Supported by the National Natural Science Foundation of China(No.82271063No.82471054)Central Guidance for Local Scientific and Technological Development Funding Projects(No.2024ZY01057).
文摘The immune system is involved in many age-related pathological changes,also plays an important role in tissue regeneration after injury.But no immune involvement has been discussed regarding cataract since it is presumed that lens has no source of immune cells as an avascular zone.Latest research has challenged the longstanding view of the lens as an immune-privileged tissue,revealing the presence of resident immune cells and active immune responses within the lens.Thus,we summarized the immune involvement in maintaining lens homeostasis,which may be a deleterious role in the induction of lens opacification if inappropriately activated.Furthermore,bioengineer-based immunomodulatory therapies to fine-tune the micro immune environment within lens may be future strategies for in situ lens regeneration,as a novel treatment for cataract.
文摘AIM:To compare the clinical outcomes of extended depth-of-focus intraocular lenses(EDOF IOLs)using either micromonovision implantation or mixed implantation of EDOF and diffractive bifocal IOLs.METHODS:This retrospective clinical trial included 130 patients(260 eyes),who were divided into two groups.Group RR comprised 70 patients(140 eyes)bilaterally implanted with ZXR00 IOLs(Tecnis ZXR00,where one target was-0.5 D to-0.75 D and the other was 0 to-0.25 D).Group RM comprised 60 patients(120 eyes)unilaterally implanted with both ZXR00 and ZMB00 IOLs(Tecnis ZMB00,0 to-0.25 D).Postoperative outcomes were compared after 3 mo,including visual acuity,defocus curves,stereoacuity,modulation transfer functions(MTFs),higher-order aberrations,and Visual Function-14(VF-14)questionnaire responses.RESULTS:Group RR had superior bilateral intermediate vision,while the group RM had superior bilateral near vision(both P<0.05).Group RM also exhibited superior MTFs and reduced higher-order aberrations(both P<0.05).Stereoacuity and VF-14 questionnaire results showed no statistically significant difference between groups(P>0.05).CONCLUSION:The implantation of micromonovision has significantly improved near vision.IOLs and their collocation can be customized according to individual patient needs to achieve precise treatment and provide cataract patients with high-quality vision.
文摘Objective To compare the efficacy of toric implantable collamer lens(Toric-ICL)and femtosecond laser-assisted in situ keratomileusis(FS-LASIK)for myopia correction in patients with moderate to high myopia complicated with astigmatism.Methods We retrospectively collected data from 64 patients(aged 18-42 years)with moderate to high myopia complicated with astigmatism(128 eyes)undergoing either Toric-ICL(28 patients/56 eyes)or FS-LASIK(36 patients/72 eyes)at our department between January,2019 and December,2020.The changes of uncorrected distance visual acuity(UCVA),spherical equivalent(SE),mean astigmatism correction index(CI),corneal endothelial cell density(ECD)and intraocular pressure(IOP)following the procedures were compared between the two groups.Results In FS-LASIK group,all the eyes(72/72)achieved an UCVA≥1.0,similar to the rate in Toric-ICL group(55/56 eyes;P=0.2374).The postoperative SE was also comparable between FS-LASIK and Toric-ICL groups[0.43±0.06 D(range:-1.0 to 1.50 D)vs 0.38±0.05 D(range:-0.75 to 1.00 D);P=0.56].The mean astigmatism CI was significantly higher in FS-LASIK group than in Toric-ICL group(0.8561 vs 0.7176;P<0.0001),and 88.89%of the eyes in FS-LASIK group and 69.64%in Toric-ICL group had postoperative astigmatism≤0.50 D.No significant changes were observed in postoperative corneal ECD in FS-LASIK group,whereas ECD decreased significantly after the procedure in Toric-ICL group(P=0.0057).The patients undergoing Toric-ICL exhibited no significant changes of postoperative IOP,but the patients receiving FS-LASIK had significantly reduced IOP after the procedure(P<0.001).Conclusion Although the patients included in Toric-ICL group had higher myopia and astigmatism,Toric-ICL still showed better predictability and efficacy for astigmatic correction in Toric-ICL group.Toric-ICL is an effective and safe equivalent of FS-LASIK for correcting moderate myopia but can be more advantageous for correcting high myopia with astigmatism.
基金supported by the National Natural Science Foundation of China(82371089).
文摘Objective:To evaluate the performance of orthokeratology(ortho-k)lens reordering using software-designed system,so as to determine the feasibility of ortho-k lens reordering without discontinuing lens wear.Methods:This study is a retrospective analysis of data of ortho-k lens wearers who had a history of short-term discontinuation of lens wear.A total of 94 individuals aged over 8 years with spherical equivalent refraction ranging from-0.50 to-6.50 diopters were included.The corneal topography data at baseline(before ortho-k)and after lens wear discontinuation(cessation of ortho-k treatment)were imported separately into the lens-design software,along with corresponding refraction data.Subsequently,corneal and lens parameters were generated and compared.Intraclass correlation coefficients(ICC)were calculated,and Bland and Altman analyses were conducted.Results:All 94 children were involved in the retrospective analysis.Compared with baseline data,there was a high level of consistency between Rwo(without discontinuation)and Rwith(with discontinuation),with an ICC of 0.96(P<0.001).Furthermore,the comparison of lens parameters generated by the Easyfit software between baseline and after short-term discontinuation showed a high degree of consistency,with all of the ICC values exceeding 0.90.Similar results were obtained using the WAVE software,as both ICC values and Bland-Altman plots demonstrated a high level of consistency in lens parameters between two conditions(nearly all data points fell within the 95%LoAs).Conclusions:It is feasible to directly reorder new ortho-k lenses using software fitting approaches.However,further investigations are necessary to validate their practicability in a clinical setting.
