Avian ovaries develop asymmetrically apart from prey birds,with only the left ovary growing more towards functional organ.Here,we analyze over 135,000 cells from chick's left and right ovaries at six distinct embr...Avian ovaries develop asymmetrically apart from prey birds,with only the left ovary growing more towards functional organ.Here,we analyze over 135,000 cells from chick's left and right ovaries at six distinct embryonic developmental stages utilizing single-cell transcriptome sequencing.We delineate gene expression patterns across 15 cell types within these embryo ovaries,revealing side-specific development.The left ovaries exhibit cortex cells,zygotene germ cells,and transcriptional changes unique to the left side.Differential gene expression analysis further identifies specific markers and pathways active in these cell types,highlighting the asymmetry in ovarian development.A fine-scale analysis of the germ cell meiotic transcriptome reveals seven distinct clusters with gene expression patterns specific to various meiotic stages.The study also identifies signaling pathways and intercellular communications,particularly between pre-granulosa and germ cells.Spatial transcriptome analysis shows the asymmetry,demonstrating cortex cells exclusively in the left ovary,modulating neighboring cell types through putative secreted signaling molecules.Overall,this single-cell analysis provides insights into the molecular mechanisms of the asymmetric development of avian ovaries,particularly the significant role of cortex cells in the left ovary.展开更多
Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo development.Defects in the process can result in severe organ mispositioning.Coiled-coil domain containin...Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo development.Defects in the process can result in severe organ mispositioning.Coiled-coil domain containing 141(CCDC141)has been previously known as a centrosome-related gene,but its role in left-right(LR)asymmetry has not been characterized.In this study,we utilize the zebrafish model and human exome analysis to elucidate the function of ccdc141 in laterality defects.The knockdown of ccdc141 in zebrafish disrupts early LR signaling pathways,cilia function,and Kupffer's vesicle formation.Unlike ccdc141-knockdown embryos exhibiting aberrant LR patterns,ccdc141-null mutants show no apparent abnormality,suggesting a genetic compensation response effect.In parallel,we observe a marked reduction inα-tubulin acetylation levels in the ccdc141 crispants.The treatment with histone deacetylase(HDAC)inhibitors,particularly the HDAC6 inhibitor,rescues the ccdc141 crispant phenotypes.Furthermore,exome analysis of 70 patients with laterality defects reveals an increased burden of CCDC141 mutations,with in-vivo studies verifying the pathogenicity of the patient mutation CCDC141-R123G.Our findings highlight the critical role of ccdc141 in ciliogenesis and demonstrate that CCDC141 mutations lead to abnormal LR patterns,identifying it as a candidate gene for laterality defects.展开更多
Levitation chassis, as an extremely important component of maglev vehicles, provides functions of transmitting levitation force and steering force, and directly affects the safety performance of the vehicle. Based on ...Levitation chassis, as an extremely important component of maglev vehicles, provides functions of transmitting levitation force and steering force, and directly affects the safety performance of the vehicle. Based on the vertical dynamics model of the levitation chassis, kinetic equations of the model are established, and a simulation program is designed to analyze the structural decoupling function of the chassis, especially under the influence of elastic constraints between the left and right modules, which are exclusively owned by maglev vehicles. A finite element model of the levitation chassis based on left-right decoupling is constructed. Analysis results of the model show that the mechanical properties of the chassis tailored for the vehicle meet the design requirements, and the stiffness and strength is adequate to bear the weight of the whole vehicle.展开更多
A novel method of constructing sentiment lexicon of new words(SLNW)is proposed to realize effective Weibo sentiment analysis by integrating existing lexicons of sentiments,lexicons of degree,negation and network.Based...A novel method of constructing sentiment lexicon of new words(SLNW)is proposed to realize effective Weibo sentiment analysis by integrating existing lexicons of sentiments,lexicons of degree,negation and network.Based on left-right entropy and mutual information(MI)neologism discovery algorithms,this new algorithm divides N-gram to obtain strings dynamically instead of relying on fixed sliding window when using Trie as data structure.The sentiment-oriented point mutual information(SO-PMI)algorithm with Laplacian smoothing is used to distinguish sentiment tendency of new words found in the data set to form SLNW by putting new words to basic sentiment lexicon.Experiments show that the sentiment analysis based on SLNW performs better than others.Precision,recall and F-measure are improved in both topic and non-topic Weibo data sets.展开更多
In the framework of the left-right twin Higgs(LRTH) model, we study the Higgs boson and single top quark associated production at the LHC. We investigate the processes pp → thj, pp → thˉb and pp → th W at the 8(14...In the framework of the left-right twin Higgs(LRTH) model, we study the Higgs boson and single top quark associated production at the LHC. We investigate the processes pp → thj, pp → thˉb and pp → th W at the 8(14) Te V LHC and find that the production cross sections of the three processes can be enhanced at different levels. Among them,the production cross section of the process pp → thˉb is enhanced significantly due to the contribution of the new particles predicted by the LRTH model.展开更多
Based on new rolling-sliding compound bearings,the wear between the one-way spiral hollow cylindrical roller and the ribs of the inner and outer ring of rolling-sliding compound bearings is reduced by innovational str...Based on new rolling-sliding compound bearings,the wear between the one-way spiral hollow cylindrical roller and the ribs of the inner and outer ring of rolling-sliding compound bearings is reduced by innovational structural design. A new left-right spiral hollow cylindrical roller is proposed to replace the one-way spiral hollow cylindrical roller. The finite element analysis models of ordinary cylindrical rollers,one-way spiral hollow cylindrical rollers and left-right spiral hollow cylindrical rollers are respectively established by ABAQUS.The axial displacement of their center mass and the stress distribution of left-right spiral hollow cylindrical rollers are compared and analyzed. Theoretical study results show that this new left-right spiral hollow cylindrical roller not only inherits the advantages of one-way spiral hollow cylindrical rollers,but also avoids the axial offset and the serious wear of the one-way spiral hollow cylindrical roller. And the theory research conclusion is verified by the experiment. The left-right spiral hollow cylindrical roller has the advantages to overcome boundary stress concentration like logarithmic convex roller. The rolling-sliding compound bearings equipped with the new rollers can be better to adapt to the impact of vibration load.展开更多
In the context of the left-right twin Higgs （LRTH） model, we fist study single production of the standard model （SM） top quark via e-γ collisions. We find that the corrections of the LRTH model to the cross secti...In the context of the left-right twin Higgs （LRTH） model, we fist study single production of the standard model （SM） top quark via e-γ collisions. We find that the corrections of the LRTH model to the cross section of the process e-γ→vebt might be observed only for f ≤750 GeV and the heavy top quark mass scale M ≥500 GeV in future high energy linear e^＋e^- collider （LC） experiment with the center-of-mass （CM） energy √s = 500 GeV and a yearly integrated luminosity of ￡ = 100 fb^-1. We also consider single production of the heavy top quark T via e-γ collisions. Our numerical results show that the possible signals of the heavy top quark T might be observed via the decay channel T →Ф^＋b→tbb in future LC experiment with √s = 3 TeV and ￡ = 500 fb^-1.展开更多
The left-right twin Higgs （LRTH） model predicts the existence of three additional Higgs bosons： one neutral Higgs φo and a pair of charged Higgs bosons φ±. In this paper, we study two pair production process...The left-right twin Higgs （LRTH） model predicts the existence of three additional Higgs bosons： one neutral Higgs φo and a pair of charged Higgs bosons φ±. In this paper, we study two pair production processes of these new particles at the next generation eγ colliders, i.e., e-γ → e-φ＋φ- , and e-γ→vRφ-φ0. We find that the production cross section of the process e-γ → e-φ＋φ- are at the level of several tens fb, the production cross section of the process e-γ→vRφ-φ0 can reach 0.35 fb with the reasonable parameter values. As long as the charged Higgs bosons are not too heavy, we conclude that these processes might be used to test for the left-right twin Higgs model in future high-energy linear collider experiments.展开更多
At the CERN large hadron collider （LHC）, production of the Higgs boson in association with Z or W bosons provides a dramatic experimental signal for detecting the standard model （SM） Higgs boson. In this paper, we...At the CERN large hadron collider （LHC）, production of the Higgs boson in association with Z or W bosons provides a dramatic experimental signal for detecting the standard model （SM） Higgs boson. In this paper, we consider the contributions of the left-right twin Higgs （LRTH） model to the processes qq＇ --~ Z（W）H. Our numerical results show that, in the favorable parameter spaces, the cross sections deviate distinctly from the predictions of the SM. The possible signals of the LRTH model can be detected via these processes at the LHC experiments.展开更多
The twin Higgs mechanism has recently been proposed to solve the little hierarchy problem. In the context of the left-right twin Higgs （LRTH） model, we discuss single production of the new charged gauge boson WH^- ,...The twin Higgs mechanism has recently been proposed to solve the little hierarchy problem. In the context of the left-right twin Higgs （LRTH） model, we discuss single production of the new charged gauge boson WH^- , which is predicted by the left-right twin Higgs model, in association with top quark at the CERN Large Hadron Collider （LHC）. It is found that, for a typical nonzero value of mass mixing parameter M = 150 GeV in the LRTH model, the production cross section is in the range of 3 ×10^-2 - 6.07×10^3 fb at the LHC. As long as the WH^- is not too heavy, the possible signatures of the heavy charged gauge boson might be detected at the LHC experiments.展开更多
All the possible CP-conserving non-linear operators up to the p^4-order in the Lagrangian expansion are analysed here for the left-right symmetric model in the non-linear electroweak chiral context coupled to a light ...All the possible CP-conserving non-linear operators up to the p^4-order in the Lagrangian expansion are analysed here for the left-right symmetric model in the non-linear electroweak chiral context coupled to a light dynamical Higgs. The low energy effects will be triggered by an emerging new physics field content in the nature, more specifically,from spin-1 resonances sourced by the straightforward extension of the SM local gauge symmetry to the larger local group SU(2)_L × SU(2)_R× U(1)_(B-L). Low energy phenomenology will be altered by integrating out the resonances from the physical spectrum, being manifested through induced corrections onto the left handed operators. Such modifications are weighted by powers of the scales ratio implied by the symmetries of the model and will determine the size of the effective operator basis to be used. The recently observed diboson excess around the invariant mass 1.8 TeV–2 TeV entails a scale suppression that suggests to encode the low energy effects via a much smaller set of effective operators.展开更多
A closed linear relation T in a Banach space X is called left(resp. right) Fredholm if it is upper(resp. lower) semi Fredholm and its range(resp. null space) is topologically complemented in X. We say that T is left(r...A closed linear relation T in a Banach space X is called left(resp. right) Fredholm if it is upper(resp. lower) semi Fredholm and its range(resp. null space) is topologically complemented in X. We say that T is left(resp. right) Browder if it is left(resp. right)Fredholm and has a finite ascent(resp. descent). In this paper, we analyze the stability of the left(resp. right) Fredholm and the left(resp. right) Browder linear relations under commuting Riesz operator perturbations. Recent results of Zivkovic et al. to the case of bounded operators are covered.展开更多
探讨不同激发方式在右心声学造影(agitated saline contrast echocardiography,ASCE)诊断卵圆孔未闭(patent foramen ovale,PFO)合并右向左分流(right to left shunt,RLS)中的作用。纳入2023年1月—2024年6月于川北医学院附属医院心内...探讨不同激发方式在右心声学造影(agitated saline contrast echocardiography,ASCE)诊断卵圆孔未闭(patent foramen ovale,PFO)合并右向左分流(right to left shunt,RLS)中的作用。纳入2023年1月—2024年6月于川北医学院附属医院心内科就诊的328例疑似PFO患者,采用咳嗽、改良蹲立动作、束臂试验及联合激发,以经食管超声(TEE)为金标准,比较不同方式的诊断效能。结果显示,束臂试验对中-大量RLS的检出率(45.8%)高于咳嗽(28.9%)和改良蹲立动作(35.4%);二阶法中咳嗽+束臂试验的检出率最高(52.1%),三阶法的检出率(54.3%)未显著提升但稳定性更佳;束臂试验及三阶法的AUC分别为0.842和0.891,显著优于单一激发。研究发现,束臂试验及联合激发可提高PFO-RLS检出率,推荐将其作为个体化联合方案以优化诊断效能。展开更多
基金funded by the Natural Science Foundation of Sichuan Province(2022NSFSC1767)the National Natural Science Foundation of China(32360828)。
文摘Avian ovaries develop asymmetrically apart from prey birds,with only the left ovary growing more towards functional organ.Here,we analyze over 135,000 cells from chick's left and right ovaries at six distinct embryonic developmental stages utilizing single-cell transcriptome sequencing.We delineate gene expression patterns across 15 cell types within these embryo ovaries,revealing side-specific development.The left ovaries exhibit cortex cells,zygotene germ cells,and transcriptional changes unique to the left side.Differential gene expression analysis further identifies specific markers and pathways active in these cell types,highlighting the asymmetry in ovarian development.A fine-scale analysis of the germ cell meiotic transcriptome reveals seven distinct clusters with gene expression patterns specific to various meiotic stages.The study also identifies signaling pathways and intercellular communications,particularly between pre-granulosa and germ cells.Spatial transcriptome analysis shows the asymmetry,demonstrating cortex cells exclusively in the left ovary,modulating neighboring cell types through putative secreted signaling molecules.Overall,this single-cell analysis provides insights into the molecular mechanisms of the asymmetric development of avian ovaries,particularly the significant role of cortex cells in the left ovary.
基金supported by the National Natural Science Foundation of China(81970264).
文摘Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo development.Defects in the process can result in severe organ mispositioning.Coiled-coil domain containing 141(CCDC141)has been previously known as a centrosome-related gene,but its role in left-right(LR)asymmetry has not been characterized.In this study,we utilize the zebrafish model and human exome analysis to elucidate the function of ccdc141 in laterality defects.The knockdown of ccdc141 in zebrafish disrupts early LR signaling pathways,cilia function,and Kupffer's vesicle formation.Unlike ccdc141-knockdown embryos exhibiting aberrant LR patterns,ccdc141-null mutants show no apparent abnormality,suggesting a genetic compensation response effect.In parallel,we observe a marked reduction inα-tubulin acetylation levels in the ccdc141 crispants.The treatment with histone deacetylase(HDAC)inhibitors,particularly the HDAC6 inhibitor,rescues the ccdc141 crispant phenotypes.Furthermore,exome analysis of 70 patients with laterality defects reveals an increased burden of CCDC141 mutations,with in-vivo studies verifying the pathogenicity of the patient mutation CCDC141-R123G.Our findings highlight the critical role of ccdc141 in ciliogenesis and demonstrate that CCDC141 mutations lead to abnormal LR patterns,identifying it as a candidate gene for laterality defects.
基金supported by the National Natural Science Foundation of China (No. 51175442)the Fundamental Research Funds for the Central Universities (SWJTU12CX040)
文摘Levitation chassis, as an extremely important component of maglev vehicles, provides functions of transmitting levitation force and steering force, and directly affects the safety performance of the vehicle. Based on the vertical dynamics model of the levitation chassis, kinetic equations of the model are established, and a simulation program is designed to analyze the structural decoupling function of the chassis, especially under the influence of elastic constraints between the left and right modules, which are exclusively owned by maglev vehicles. A finite element model of the levitation chassis based on left-right decoupling is constructed. Analysis results of the model show that the mechanical properties of the chassis tailored for the vehicle meet the design requirements, and the stiffness and strength is adequate to bear the weight of the whole vehicle.
基金Natural Science Foundation of Shanghai,China(No.18ZR1401200)Special Fund for Innovation and Development of Shanghai Industrial Internet,China(No.2019-GYHLW-01004)。
文摘A novel method of constructing sentiment lexicon of new words(SLNW)is proposed to realize effective Weibo sentiment analysis by integrating existing lexicons of sentiments,lexicons of degree,negation and network.Based on left-right entropy and mutual information(MI)neologism discovery algorithms,this new algorithm divides N-gram to obtain strings dynamically instead of relying on fixed sliding window when using Trie as data structure.The sentiment-oriented point mutual information(SO-PMI)algorithm with Laplacian smoothing is used to distinguish sentiment tendency of new words found in the data set to form SLNW by putting new words to basic sentiment lexicon.Experiments show that the sentiment analysis based on SLNW performs better than others.Precision,recall and F-measure are improved in both topic and non-topic Weibo data sets.
基金Supported by the National Natural Science Foundation of China under Grant No.U1404113the Aid Project for the Mainstay Young Teachers in Henan Provincial Institutions of Higher Education of China under Grant Nos.2016GGJS-135,2014GGJS-283Colleges and Universities in Henan Province Key Scientific Research Project for 2016(16B140002)
文摘In the framework of the left-right twin Higgs(LRTH) model, we study the Higgs boson and single top quark associated production at the LHC. We investigate the processes pp → thj, pp → thˉb and pp → th W at the 8(14) Te V LHC and find that the production cross sections of the three processes can be enhanced at different levels. Among them,the production cross section of the process pp → thˉb is enhanced significantly due to the contribution of the new particles predicted by the LRTH model.
基金Sponsored by the National Natural Science Foundation of China(Grant No.51065009)the Science Foundation of Jiangxi Province Education Department of China(Grant No.GJJ14392GJJ14360)
文摘Based on new rolling-sliding compound bearings,the wear between the one-way spiral hollow cylindrical roller and the ribs of the inner and outer ring of rolling-sliding compound bearings is reduced by innovational structural design. A new left-right spiral hollow cylindrical roller is proposed to replace the one-way spiral hollow cylindrical roller. The finite element analysis models of ordinary cylindrical rollers,one-way spiral hollow cylindrical rollers and left-right spiral hollow cylindrical rollers are respectively established by ABAQUS.The axial displacement of their center mass and the stress distribution of left-right spiral hollow cylindrical rollers are compared and analyzed. Theoretical study results show that this new left-right spiral hollow cylindrical roller not only inherits the advantages of one-way spiral hollow cylindrical rollers,but also avoids the axial offset and the serious wear of the one-way spiral hollow cylindrical roller. And the theory research conclusion is verified by the experiment. The left-right spiral hollow cylindrical roller has the advantages to overcome boundary stress concentration like logarithmic convex roller. The rolling-sliding compound bearings equipped with the new rollers can be better to adapt to the impact of vibration load.
基金supported by National Natural Science Foundation of China under Grant No.10775039
文摘In the context of the left-right twin Higgs （LRTH） model, we fist study single production of the standard model （SM） top quark via e-γ collisions. We find that the corrections of the LRTH model to the cross section of the process e-γ→vebt might be observed only for f ≤750 GeV and the heavy top quark mass scale M ≥500 GeV in future high energy linear e^＋e^- collider （LC） experiment with the center-of-mass （CM） energy √s = 500 GeV and a yearly integrated luminosity of ￡ = 100 fb^-1. We also consider single production of the heavy top quark T via e-γ collisions. Our numerical results show that the possible signals of the heavy top quark T might be observed via the decay channel T →Ф^＋b→tbb in future LC experiment with √s = 3 TeV and ￡ = 500 fb^-1.
基金Supported in Part by the National Natural Science Foundation of China under Grant No.10775039 the Foundation of He'nan Educational Committee under Grant No.2009B140003
文摘The left-right twin Higgs （LRTH） model predicts the existence of three additional Higgs bosons： one neutral Higgs φo and a pair of charged Higgs bosons φ±. In this paper, we study two pair production processes of these new particles at the next generation eγ colliders, i.e., e-γ → e-φ＋φ- , and e-γ→vRφ-φ0. We find that the production cross section of the process e-γ → e-φ＋φ- are at the level of several tens fb, the production cross section of the process e-γ→vRφ-φ0 can reach 0.35 fb with the reasonable parameter values. As long as the charged Higgs bosons are not too heavy, we conclude that these processes might be used to test for the left-right twin Higgs model in future high-energy linear collider experiments.
基金Supported by the National Natural Science Foundation of China under Grant Nos. 10975047 and 10979008
文摘At the CERN large hadron collider （LHC）, production of the Higgs boson in association with Z or W bosons provides a dramatic experimental signal for detecting the standard model （SM） Higgs boson. In this paper, we consider the contributions of the left-right twin Higgs （LRTH） model to the processes qq＇ --~ Z（W）H. Our numerical results show that, in the favorable parameter spaces, the cross sections deviate distinctly from the predictions of the SM. The possible signals of the LRTH model can be detected via these processes at the LHC experiments.
基金The project supported by National Natural Science Foundation of China under Grant Nos.10775039 and 10575029
文摘The twin Higgs mechanism has recently been proposed to solve the little hierarchy problem. In the context of the left-right twin Higgs （LRTH） model, we discuss single production of the new charged gauge boson WH^- , which is predicted by the left-right twin Higgs model, in association with top quark at the CERN Large Hadron Collider （LHC）. It is found that, for a typical nonzero value of mass mixing parameter M = 150 GeV in the LRTH model, the production cross section is in the range of 3 ×10^-2 - 6.07×10^3 fb at the LHC. As long as the WH^- is not too heavy, the possible signatures of the heavy charged gauge boson might be detected at the LHC experiments.
基金KITPC financial support during the completion of this work
文摘All the possible CP-conserving non-linear operators up to the p^4-order in the Lagrangian expansion are analysed here for the left-right symmetric model in the non-linear electroweak chiral context coupled to a light dynamical Higgs. The low energy effects will be triggered by an emerging new physics field content in the nature, more specifically,from spin-1 resonances sourced by the straightforward extension of the SM local gauge symmetry to the larger local group SU(2)_L × SU(2)_R× U(1)_(B-L). Low energy phenomenology will be altered by integrating out the resonances from the physical spectrum, being manifested through induced corrections onto the left handed operators. Such modifications are weighted by powers of the scales ratio implied by the symmetries of the model and will determine the size of the effective operator basis to be used. The recently observed diboson excess around the invariant mass 1.8 TeV–2 TeV entails a scale suppression that suggests to encode the low energy effects via a much smaller set of effective operators.
文摘A closed linear relation T in a Banach space X is called left(resp. right) Fredholm if it is upper(resp. lower) semi Fredholm and its range(resp. null space) is topologically complemented in X. We say that T is left(resp. right) Browder if it is left(resp. right)Fredholm and has a finite ascent(resp. descent). In this paper, we analyze the stability of the left(resp. right) Fredholm and the left(resp. right) Browder linear relations under commuting Riesz operator perturbations. Recent results of Zivkovic et al. to the case of bounded operators are covered.
文摘探讨不同激发方式在右心声学造影(agitated saline contrast echocardiography,ASCE)诊断卵圆孔未闭(patent foramen ovale,PFO)合并右向左分流(right to left shunt,RLS)中的作用。纳入2023年1月—2024年6月于川北医学院附属医院心内科就诊的328例疑似PFO患者,采用咳嗽、改良蹲立动作、束臂试验及联合激发,以经食管超声(TEE)为金标准,比较不同方式的诊断效能。结果显示,束臂试验对中-大量RLS的检出率(45.8%)高于咳嗽(28.9%)和改良蹲立动作(35.4%);二阶法中咳嗽+束臂试验的检出率最高(52.1%),三阶法的检出率(54.3%)未显著提升但稳定性更佳;束臂试验及三阶法的AUC分别为0.842和0.891,显著优于单一激发。研究发现,束臂试验及联合激发可提高PFO-RLS检出率,推荐将其作为个体化联合方案以优化诊断效能。
