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Insights into left-right asymmetric development of chicken ovary at the single-cell level 被引量:1
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作者 Tao Wang Dong Leng +5 位作者 Zhongkun Cai Binlong Chen Jing Li Hua Kui Diyan Li Zhuanjian Li 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2024年第11期1265-1277,共13页
Avian ovaries develop asymmetrically apart from prey birds,with only the left ovary growing more towards functional organ.Here,we analyze over 135,000 cells from chick's left and right ovaries at six distinct embr... Avian ovaries develop asymmetrically apart from prey birds,with only the left ovary growing more towards functional organ.Here,we analyze over 135,000 cells from chick's left and right ovaries at six distinct embryonic developmental stages utilizing single-cell transcriptome sequencing.We delineate gene expression patterns across 15 cell types within these embryo ovaries,revealing side-specific development.The left ovaries exhibit cortex cells,zygotene germ cells,and transcriptional changes unique to the left side.Differential gene expression analysis further identifies specific markers and pathways active in these cell types,highlighting the asymmetry in ovarian development.A fine-scale analysis of the germ cell meiotic transcriptome reveals seven distinct clusters with gene expression patterns specific to various meiotic stages.The study also identifies signaling pathways and intercellular communications,particularly between pre-granulosa and germ cells.Spatial transcriptome analysis shows the asymmetry,demonstrating cortex cells exclusively in the left ovary,modulating neighboring cell types through putative secreted signaling molecules.Overall,this single-cell analysis provides insights into the molecular mechanisms of the asymmetric development of avian ovaries,particularly the significant role of cortex cells in the left ovary. 展开更多
关键词 CHICKEN OVARY Asymmetric development left-right asymmetry Single-cell transcriptome Pre-granulosa Cellular crosstalk
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ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish 被引量:1
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作者 Pengcheng Wang Wenxiang Shi +6 位作者 Sijie Liu Yunjing Shi Xuechao Jiang Fen Li Sun Chen Kun Sun Rang Xu 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2024年第9期934-946,共13页
Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo development.Defects in the process can result in severe organ mispositioning.Coiled-coil domain containin... Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo development.Defects in the process can result in severe organ mispositioning.Coiled-coil domain containing 141(CCDC141)has been previously known as a centrosome-related gene,but its role in left-right(LR)asymmetry has not been characterized.In this study,we utilize the zebrafish model and human exome analysis to elucidate the function of ccdc141 in laterality defects.The knockdown of ccdc141 in zebrafish disrupts early LR signaling pathways,cilia function,and Kupffer's vesicle formation.Unlike ccdc141-knockdown embryos exhibiting aberrant LR patterns,ccdc141-null mutants show no apparent abnormality,suggesting a genetic compensation response effect.In parallel,we observe a marked reduction inα-tubulin acetylation levels in the ccdc141 crispants.The treatment with histone deacetylase(HDAC)inhibitors,particularly the HDAC6 inhibitor,rescues the ccdc141 crispant phenotypes.Furthermore,exome analysis of 70 patients with laterality defects reveals an increased burden of CCDC141 mutations,with in-vivo studies verifying the pathogenicity of the patient mutation CCDC141-R123G.Our findings highlight the critical role of ccdc141 in ciliogenesis and demonstrate that CCDC141 mutations lead to abnormal LR patterns,identifying it as a candidate gene for laterality defects. 展开更多
关键词 left-right axis CILIA WES Laterality defects ZEBRAFISH CCDC141
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Structure analysis of levitation chassis of medium-to-low speed maglev vehicles based on left-right decoupling 被引量:3
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作者 Fang LIU Jinwen DONG Yongzhi JING 《Journal of Modern Transportation》 2012年第2期82-87,共6页
Levitation chassis, as an extremely important component of maglev vehicles, provides functions of transmitting levitation force and steering force, and directly affects the safety performance of the vehicle. Based on ... Levitation chassis, as an extremely important component of maglev vehicles, provides functions of transmitting levitation force and steering force, and directly affects the safety performance of the vehicle. Based on the vertical dynamics model of the levitation chassis, kinetic equations of the model are established, and a simulation program is designed to analyze the structural decoupling function of the chassis, especially under the influence of elastic constraints between the left and right modules, which are exclusively owned by maglev vehicles. A finite element model of the levitation chassis based on left-right decoupling is constructed. Analysis results of the model show that the mechanical properties of the chassis tailored for the vehicle meet the design requirements, and the stiffness and strength is adequate to bear the weight of the whole vehicle. 展开更多
关键词 maglev vehicle levitation chassis DYNAMICS left-right decoupling finite element
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Sentiment Lexicon Construction Based on Improved Left-Right Entropy Algorithm 被引量:1
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作者 YU Shoujian WANG Baoying LU Ting 《Journal of Donghua University(English Edition)》 CAS 2022年第1期65-71,共7页
A novel method of constructing sentiment lexicon of new words(SLNW)is proposed to realize effective Weibo sentiment analysis by integrating existing lexicons of sentiments,lexicons of degree,negation and network.Based... A novel method of constructing sentiment lexicon of new words(SLNW)is proposed to realize effective Weibo sentiment analysis by integrating existing lexicons of sentiments,lexicons of degree,negation and network.Based on left-right entropy and mutual information(MI)neologism discovery algorithms,this new algorithm divides N-gram to obtain strings dynamically instead of relying on fixed sliding window when using Trie as data structure.The sentiment-oriented point mutual information(SO-PMI)algorithm with Laplacian smoothing is used to distinguish sentiment tendency of new words found in the data set to form SLNW by putting new words to basic sentiment lexicon.Experiments show that the sentiment analysis based on SLNW performs better than others.Precision,recall and F-measure are improved in both topic and non-topic Weibo data sets. 展开更多
关键词 sentiment lexicon new word discovery left-right entropy sentiment analysis point mutual information(PMI)
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Higgs and Single Top Associated Production at the LHC in the Left-Right Twin Higgs Model
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作者 蒋兴雨 韩金钟 +1 位作者 杨光 喻纯旭 《Communications in Theoretical Physics》 SCIE CAS CSCD 2017年第4期415-420,共6页
In the framework of the left-right twin Higgs(LRTH) model, we study the Higgs boson and single top quark associated production at the LHC. We investigate the processes pp → thj, pp → thˉb and pp → th W at the 8(14... In the framework of the left-right twin Higgs(LRTH) model, we study the Higgs boson and single top quark associated production at the LHC. We investigate the processes pp → thj, pp → thˉb and pp → th W at the 8(14) Te V LHC and find that the production cross sections of the three processes can be enhanced at different levels. Among them,the production cross section of the process pp → thˉb is enhanced significantly due to the contribution of the new particles predicted by the LRTH model. 展开更多
关键词 Higgs boson top quark left-right twin Higgs model
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Characteristics of Left-Right Spiral Hollow Cylindrical Roller
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作者 Liming Lu Qiping Chen Yujiang Qin 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2015年第2期74-78,共5页
Based on new rolling-sliding compound bearings,the wear between the one-way spiral hollow cylindrical roller and the ribs of the inner and outer ring of rolling-sliding compound bearings is reduced by innovational str... Based on new rolling-sliding compound bearings,the wear between the one-way spiral hollow cylindrical roller and the ribs of the inner and outer ring of rolling-sliding compound bearings is reduced by innovational structural design. A new left-right spiral hollow cylindrical roller is proposed to replace the one-way spiral hollow cylindrical roller. The finite element analysis models of ordinary cylindrical rollers,one-way spiral hollow cylindrical rollers and left-right spiral hollow cylindrical rollers are respectively established by ABAQUS.The axial displacement of their center mass and the stress distribution of left-right spiral hollow cylindrical rollers are compared and analyzed. Theoretical study results show that this new left-right spiral hollow cylindrical roller not only inherits the advantages of one-way spiral hollow cylindrical rollers,but also avoids the axial offset and the serious wear of the one-way spiral hollow cylindrical roller. And the theory research conclusion is verified by the experiment. The left-right spiral hollow cylindrical roller has the advantages to overcome boundary stress concentration like logarithmic convex roller. The rolling-sliding compound bearings equipped with the new rollers can be better to adapt to the impact of vibration load. 展开更多
关键词 left-right spiral hollow cylindrical roller finite element analysis DISPLACEMENT STRESS
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Single Production of Top Quark via e^-γ Collision in Left-Right Twin Higgs Model
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作者 LIU Yao-Bei WANG Xue-Lei +1 位作者 CAO Jun HAN Hong-Mei 《Communications in Theoretical Physics》 SCIE CAS CSCD 2008年第8期445-450,共6页
In the context of the left-right twin Higgs (LRTH) model, we fist study single production of the standard model (SM) top quark via e-γ collisions. We find that the corrections of the LRTH model to the cross secti... In the context of the left-right twin Higgs (LRTH) model, we fist study single production of the standard model (SM) top quark via e-γ collisions. We find that the corrections of the LRTH model to the cross section of the process e-γ→vebt might be observed only for f ≤750 GeV and the heavy top quark mass scale M ≥500 GeV in future high energy linear e^+e^- collider (LC) experiment with the center-of-mass (CM) energy √s = 500 GeV and a yearly integrated luminosity of £ = 100 fb^-1. We also consider single production of the heavy top quark T via e-γ collisions. Our numerical results show that the possible signals of the heavy top quark T might be observed via the decay channel T →Ф^+b→tbb in future LC experiment with √s = 3 TeV and £ = 500 fb^-1. 展开更多
关键词 left-right twin Higgs model free parameter cross section
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Production of Charged Higgs Bosons from Left-Right Twin Higgs Model at TeV Energy e^-γ Colliders
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作者 申杰奋 刘要北 +1 位作者 赵晖 曹军 《Communications in Theoretical Physics》 SCIE CAS CSCD 2010年第10期701-708,共8页
The left-right twin Higgs (LRTH) model predicts the existence of three additional Higgs bosons: one neutral Higgs φo and a pair of charged Higgs bosons φ±. In this paper, we study two pair production process... The left-right twin Higgs (LRTH) model predicts the existence of three additional Higgs bosons: one neutral Higgs φo and a pair of charged Higgs bosons φ±. In this paper, we study two pair production processes of these new particles at the next generation eγ colliders, i.e., e-γ → e-φ+φ- , and e-γ→vRφ-φ0. We find that the production cross section of the process e-γ → e-φ+φ- are at the level of several tens fb, the production cross section of the process e-γ→vRφ-φ0 can reach 0.35 fb with the reasonable parameter values. As long as the charged Higgs bosons are not too heavy, we conclude that these processes might be used to test for the left-right twin Higgs model in future high-energy linear collider experiments. 展开更多
关键词 left-right twin Higgs model charged Higgs boson ILC
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Associated ZH and WH Production in Left-Right Twin Higgs Model at LHC
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作者 张艳菊 鲁公儒 《Communications in Theoretical Physics》 SCIE CAS CSCD 2011年第7期119-124,共6页
At the CERN large hadron collider (LHC), production of the Higgs boson in association with Z or W bosons provides a dramatic experimental signal for detecting the standard model (SM) Higgs boson. In this paper, we... At the CERN large hadron collider (LHC), production of the Higgs boson in association with Z or W bosons provides a dramatic experimental signal for detecting the standard model (SM) Higgs boson. In this paper, we consider the contributions of the left-right twin Higgs (LRTH) model to the processes qq' --~ Z(W)H. Our numerical results show that, in the favorable parameter spaces, the cross sections deviate distinctly from the predictions of the SM. The possible signals of the LRTH model can be detected via these processes at the LHC experiments. 展开更多
关键词 left-right twin Higgs model large hadron collider relation corrections
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Single Production of Charged Gauge Boson W_H^-from Left-Right Twin Higgs Model in Association with Top Quark at LHC
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作者 LIU Yao-Bei WANG Xue-Lei +1 位作者 HAN Hong-Mei CAO Yong-Hua 《Communications in Theoretical Physics》 SCIE CAS CSCD 2008年第4期977-980,共4页
The twin Higgs mechanism has recently been proposed to solve the little hierarchy problem. In the context of the left-right twin Higgs (LRTH) model, we discuss single production of the new charged gauge boson WH^- ,... The twin Higgs mechanism has recently been proposed to solve the little hierarchy problem. In the context of the left-right twin Higgs (LRTH) model, we discuss single production of the new charged gauge boson WH^- , which is predicted by the left-right twin Higgs model, in association with top quark at the CERN Large Hadron Collider (LHC). It is found that, for a typical nonzero value of mass mixing parameter M = 150 GeV in the LRTH model, the production cross section is in the range of 3 ×10^-2 - 6.07×10^3 fb at the LHC. As long as the WH^- is not too heavy, the possible signatures of the heavy charged gauge boson might be detected at the LHC experiments. 展开更多
关键词 left-right twin Higgs model cross section new charged gauge boson
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Left-Right Non-Linear Dynamical Higgs
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作者 Jing Shu Juan Yepes 《Communications in Theoretical Physics》 SCIE CAS CSCD 2016年第12期643-662,共20页
All the possible CP-conserving non-linear operators up to the p^4-order in the Lagrangian expansion are analysed here for the left-right symmetric model in the non-linear electroweak chiral context coupled to a light ... All the possible CP-conserving non-linear operators up to the p^4-order in the Lagrangian expansion are analysed here for the left-right symmetric model in the non-linear electroweak chiral context coupled to a light dynamical Higgs. The low energy effects will be triggered by an emerging new physics field content in the nature, more specifically,from spin-1 resonances sourced by the straightforward extension of the SM local gauge symmetry to the larger local group SU(2)_L × SU(2)_R× U(1)_(B-L). Low energy phenomenology will be altered by integrating out the resonances from the physical spectrum, being manifested through induced corrections onto the left handed operators. Such modifications are weighted by powers of the scales ratio implied by the symmetries of the model and will determine the size of the effective operator basis to be used. The recently observed diboson excess around the invariant mass 1.8 TeV–2 TeV entails a scale suppression that suggests to encode the low energy effects via a much smaller set of effective operators. 展开更多
关键词 left-right model nonlinear invariance CP symmetry SU(2)×SU(2)×U(1) effective Lagrangian Higgs couplings
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LEFT-RIGHT BROWDER LINEAR RELATIONS AND RIESZ PERTURBATIONS
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作者 Teresa ALVAREZ 《Acta Mathematica Scientia》 SCIE CSCD 2017年第5期1437-1452,共16页
A closed linear relation T in a Banach space X is called left(resp. right) Fredholm if it is upper(resp. lower) semi Fredholm and its range(resp. null space) is topologically complemented in X. We say that T is left(r... A closed linear relation T in a Banach space X is called left(resp. right) Fredholm if it is upper(resp. lower) semi Fredholm and its range(resp. null space) is topologically complemented in X. We say that T is left(resp. right) Browder if it is left(resp. right)Fredholm and has a finite ascent(resp. descent). In this paper, we analyze the stability of the left(resp. right) Fredholm and the left(resp. right) Browder linear relations under commuting Riesz operator perturbations. Recent results of Zivkovic et al. to the case of bounded operators are covered. 展开更多
关键词 left and right Fredholm linear relations left and right Browder linear relations Riesz perturbations
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Two Higgs bi-doublet left-right model with spontaneous P and CP violation
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作者 WU YueLiang 1↑ & ZHOU YuFeng2 1 Kavli Institute for Theoretical Physics China, Institute of Theoretical Physics, Chinese Academy of Sci- ences, Beijing 100190, China 2 KEK, Tsukuba, 305-0801, Japan 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2008年第12期1808-1825,共18页
A left-right symmetric model with two Higgs bi-doublet is shown to be a consistent model for both spontaneous P and CP violation. The flavor changing neutral cur- rents can be suppressed by the mechanism of approximat... A left-right symmetric model with two Higgs bi-doublet is shown to be a consistent model for both spontaneous P and CP violation. The flavor changing neutral cur- rents can be suppressed by the mechanism of approximate global U(1) family symmetry. The constraints from neural K meson mass difference ΔmK are calcu- lated and it is demonstrated that a right-handed gauge boson W2 contribution in box-diagrams with mass well below 1 TeV is allowed due to a cancelation caused by a light-charged Higgs boson with a mass range of 150-300 GeV. The W2 con- tribution to εK can be suppressed from an appropriate choice of additional CP phases appearing in the right-handed Cabbibo-Kobayashi-Maskawa matrix. The model is also found to be fully consistent with B0 mass difference ΔmB and the mixing induced CP violation sin2βJ/ψ , which is usually difficult for the model with only one Higgs bi-doublet. The new physics beyond the standard model can be directly searched at the colliders LHC and ILC. 展开更多
关键词 left-right symmetry SPONTANEOUS P and CP VIOLATION TWO HIGGS bi-doublets new physics
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Muon-pair production in the left-right symmetric model at a Z^0-factory
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作者 MAHFOUDH A B 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2010年第11期1975-1980,共6页
The potential for probing the impacts of the left-right symmetric model (LRM) on the process e + e-→μ + μ-at a proposed Z 0-factory is investigated.Under different electron-positron polarization collision modes,we ... The potential for probing the impacts of the left-right symmetric model (LRM) on the process e + e-→μ + μ-at a proposed Z 0-factory is investigated.Under different electron-positron polarization collision modes,we calculate and compare the deviations of various observables in the framework of the LRM from the standard model (SM) predictions,such as the total cross section,the distribution of the transverse momentum of μ-,and the forward-backward charge asymmetry of μ-.In addition,we present the relations between the observables and the LRM parameters.We conclude that it is possible to observe the effects of the LRM on the process e + e-→μ + μ-by using optimal observables and favorable parameters at a Z 0-factory. 展开更多
关键词 Z 0 -factory electron-positron COLLIDER μ-pair production the left-right symmetric model
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Left-right asymmetry for meson production in SIDIS process
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作者 孙博 佘俊 +2 位作者 张冰 冒亚军 马伯强 《Chinese Physics C》 SCIE CAS CSCD 2009年第12期1354-1357,共4页
We analyze the left-right asymmetry in the semi-inclusive deep inelastic scattering (SIDIS) process using a method where no weighting function are used. Considering all flavor of quarks, we reanalyze the π±pro... We analyze the left-right asymmetry in the semi-inclusive deep inelastic scattering (SIDIS) process using a method where no weighting function are used. Considering all flavor of quarks, we reanalyze the π±production and extend our calculation on the K± production. The predictions on HERMES, COMPASS and JLab kinematics with transversely polarized nucleon target are shown in this paper. 展开更多
关键词 semi-inclusive deep inelastic scattering TRANSVERSITY left-right asymmetry
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Pair production of neutral Higgs bosons from the left-right twin Higgs model via γγ collisions
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作者 马威 岳崇兴 张婷婷 《Chinese Physics C》 SCIE CAS CSCD 2011年第4期333-338,共6页
The left-right twin Higgs (LRTH) model predicts the existence of the neutral Higgs bosons (h, φ0), which can be produced in pairs (φ0φ0, hh, φ0h) via γγ collisions at the next generation e+eInternational ... The left-right twin Higgs (LRTH) model predicts the existence of the neutral Higgs bosons (h, φ0), which can be produced in pairs (φ0φ0, hh, φ0h) via γγ collisions at the next generation e+eInternational Linear Collider (ILC). Our numerical results show that the production cross section of the neutral Higgs boson pair φ0φ0 can reach 8.8 fb. The subprocess γγ → φ0φ0 might be used to test the LRTH model in future ILC experiments. 展开更多
关键词 neutral Higgs bosons left-right twin Higgs model γγ collisions
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Single vector-like top partner production in the left-right twin Higgs model at TeV energy eγ colliders
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作者 郭占营 杨光 杨炳方 《Chinese Physics C》 SCIE CAS CSCD 2013年第10期11-14,共4页
The left-right twin Higgs model contains a new vector-like heavy top quark, which mixes with the SM- like top quark. In this work, we studied the single vector-like top partner production via process e-γ→ve Tb at th... The left-right twin Higgs model contains a new vector-like heavy top quark, which mixes with the SM- like top quark. In this work, we studied the single vector-like top partner production via process e-γ→ve Tb at the International Linear Collider. We calculated the production cross section at tree level and displayed the relevant differential distributions. The result shows that there will be 125 events produced each year with s=2 TeV and the integrated luminosity Lint ≈500 fb-1, and the b-quark tagging and the relevant missing energy ET cut will be helpful to detect this new effect. 展开更多
关键词 top partner left-right twin Higgs model production cross section
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Pair production of right-handed neutrinos in the left-right twin Higgs model at ILC and LHC
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作者 LIU YaoBei CAO YongHua 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2011年第8期1398-1404,共7页
In the framework of the left-right twin Higgs model, we study pair production of the right-handed neutrinos at the International Linear Collider (ILC) and the CERN Large Hadron Collider (LHC). Our numerical results sh... In the framework of the left-right twin Higgs model, we study pair production of the right-handed neutrinos at the International Linear Collider (ILC) and the CERN Large Hadron Collider (LHC). Our numerical results show that the production cross section of the process e+e→N N is at the level of several tens fb at the ILC. However, the resonance production cross section can be significantly enhanced to the order of pb. The pair production cross section for the right-handed neutrinos is the level of several hundreds of fb at the LHC. In general, pair production of right-handed neutrinos gives rise to 2l+4j signal without missing energy. As long as the right-handed neutrinos are not too heavy, we conclude that its pair production might be used to test for the left-right twin Higgs model at the future ILC and LHC experiments. 展开更多
关键词 left-right twin Higgs model right-handed neutrino ILC
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Searches for new neutral gauge boson at the Tevatron and LHC in the left-right twin Higgs model
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作者 LIU YaoBei ZHANG WenQing YAN LeiBing 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2012年第5期757-761,共5页
In the framework of the left-right twin Higgs (LRTH) model, we study the possibilities to detect the new Z' boson at the Tevatron and LHC. First, using pp collision data collected by the DO and CDF II detectors, we... In the framework of the left-right twin Higgs (LRTH) model, we study the possibilities to detect the new Z' boson at the Tevatron and LHC. First, using pp collision data collected by the DO and CDF II detectors, we find that the LRTH Z' boson is excluded with masses below 940 GeV. Then we search for signatures of the Z' boson at the LHC from the analysis of some distributions for pp --* It+g- + X, such as the number of events, the differential cross section of the dimuon invariant mass, the distributions of the transverse momentum and the forward-backward charge asymmetry. We do our calculation for two typical values of the LHC center of mass energy (7 and 14 TeV). The numerical results show that, by applying convenient cuts on some of the observables, the dimuon invariant mass and final particle PT distributions can reveal the presence of the heavy neutral gauge boson Z' contribution in the LRTH model. 展开更多
关键词 left-right twin Higgs (LRTH) model new neutral gauge boson LHC
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c-TCD评估不同分级PFO-RLS伴偏头痛患者脑血流动力学变化的价值
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作者 赵慧萍 李晓昶 +1 位作者 万菁菁 崔智飞 《海南医学》 2026年第1期80-84,共5页
目的 探讨经颅多普勒发泡实验(c-TCD)评估不同分级卵圆孔未闭所致的右向左分流(PFO-RLS)伴偏头痛患者的脑血流动力学变化的价值。方法 回顾性选取2022年1月至2024年1月在郑州大学附属郑州中心医院神经内科就诊的100例疑似PFO-RLS伴偏头... 目的 探讨经颅多普勒发泡实验(c-TCD)评估不同分级卵圆孔未闭所致的右向左分流(PFO-RLS)伴偏头痛患者的脑血流动力学变化的价值。方法 回顾性选取2022年1月至2024年1月在郑州大学附属郑州中心医院神经内科就诊的100例疑似PFO-RLS伴偏头痛患者为研究对象,应用c-TCD及经胸超声心动图声学造影(c TTE)诊断患者是否存在PFO导致的右向左分流(PFO-RLS)并根据其分级标准进行分级(0、Ⅰ、Ⅱ、Ⅲ级),对比分析PFO-RLS 0级与PFO-RLSⅠ、Ⅱ、Ⅲ级患者之间脑部血流动力学参数[Valsalva动作(VM)、前后大脑中动脉(MCA)、收缩期峰值血流速度(Vs)、平均血流速度(Vm)、舒张期峰值血流速度(Vd)、阻力指数(RI)和搏动指数(PI)]的差异。以cTTE检查结果为金标准,采用ROC曲线分析,确定c-TCD脑血流动力学参数诊断PFO-RLS的预测价值。结果 100例患者中PFO-RLS阳性68例,其中Ⅰ级22例、Ⅱ级20例、Ⅲ级26例;VM前,Ⅰ~Ⅲ级患者MCA的Vs、Vm、Vd与0级比较差异均无统计学意义(P>0.05),但RI、PI值随患者RLS等级升高而逐步升高,且差异均有统计学意义(P<0.05);VM后,各组MCA的Vs、Vm、Vd均显著下降,RI、PI显著升高,且随患者RLS分级增加,Vs、Vm、Vd显著下降,RI、PI显著升高,差异均有统计学意义(P<0.05);VM后MCA-RI诊断PFO-RLS阳性偏头痛的AUC为0.765(95%CI:0.692~0.856),最佳临界值为RI≥0.70(敏感度为72.30%,特异度为76.50%);VM后MCA-PI诊断PFO-RLS阳性偏头痛的AUC为0.743(95%CI:0.645~0.821),最佳临界值为PI≥1.25(敏感度为78.60%,特异度为68.90%);VM后两者联合诊断PFO-RLS阳性偏头痛的AUC为0.836(95%CI:0.742~0.897),最佳临界值≥0.65(敏感度为77.40%,特异度为79.20%)。结论 不同分级PFO-RLS伴偏头痛患者之间脑血流变化趋势不同,c-TCD可通过监测脑血流动力学参数变化有效评估不同分级PFO-RLS对偏头痛患者的影响,为临床精准诊疗提供依据。 展开更多
关键词 经颅多普勒 发泡实验 卵圆孔未闭 右向左分流 偏头痛 脑血流动力学
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