Objective:To investigate the antilithiatic effect of the whole Leea macrophylla(L macrophylla) Roxb(Leeaeeae) ethanol extract in ediylene glycol-induced urolithiasis model of rats.Methods: Forty two seven weeks old ma...Objective:To investigate the antilithiatic effect of the whole Leea macrophylla(L macrophylla) Roxb(Leeaeeae) ethanol extract in ediylene glycol-induced urolithiasis model of rats.Methods: Forty two seven weeks old male wistar albino rats were randomly divided into two major groups namely:preventive(n=18) and therapeutic(n=24).Preventive group was further subdivided into 3 groups of 6 rats namely:preventive control(PC),preventive lithiatic control(PLC) and preventive lithiatic L.macrophylla(PLLM).Similarly,therapeutic group was also subdivided into 4 groups of 6 rats namely:therapeutic control(TC),therapeutic lithiatic control(TLC).therapeutic lithitatic L macrophylla(TLLM) and therapeutic lithiatic cystone(TLCYS).The lithiasis was induced by 0.75%(v/v) ethylene glycol in the drinking water of all groups except the PC and TC groups.The urinary ionic parameters such as calcium,inorganic phosphate,oxalate,magnesium & creatinine and renal morphology were altered by ediylene glycol,which were partially recovered by 14 d preventive and almost fully recovered by 28 d therapeutic intervention trials with L macrophylla extract(500 mg/kg BW daily).Results:Significant difference on recovery was observed between preventive and dierapeutic interventional trials.Anti-urolithiatic effect of cystone was significantly(P【0.001) higher than extracts.L macrophylla extract was found nontoxic in the acute toxicity test.Conclusions:The results of this study demonstrated very promising antiurolithiatic effect of L.macrophylla extract with preventive and therapeutic treatments in this experimental condition.展开更多
We aimed at reporting the chemical constituents and antimicrobial activities of Leea aequata L.,a traditional folk medicine used in Myanmar for the treatment of wounds and skin diseases.A new neolignan,(7S,8R)-9′-O-a...We aimed at reporting the chemical constituents and antimicrobial activities of Leea aequata L.,a traditional folk medicine used in Myanmar for the treatment of wounds and skin diseases.A new neolignan,(7S,8R)-9′-O-acetylcedrusin(1),a new lactam,(3S,4S)-4-chloro-3-hydroxypiperidin-2-one(2),along with 21 known compounds,including fve lignans(3-7),four favonoid glycosides(8-11),and others(12-23),were isolated from the ethanoic extract of the aerial parts of L.aequata.The structures of the new compounds were determined by NMR,MS,and ECD spectra.For all the antimicrobial tests of the 23 compounds,only 3,4,5-trihydroxybenzoic acid ethyl ester(17)showed weak inhibitory activities against Escherichia coli and Salmonella enterica subsp.enterica.展开更多
Herbal drug therapy is the most trusted system of medicine in countries like India,where people strongly believe in Ayurveda as herbs are the part of rural Indian lifestyle.Most of the diseases which have no medicine ...Herbal drug therapy is the most trusted system of medicine in countries like India,where people strongly believe in Ayurveda as herbs are the part of rural Indian lifestyle.Most of the diseases which have no medicine in allopathic system can be cured successfully by using traditional medicines.Leea indica,a traditional Chinese medicinal plant is the sole member of the family Leeaceae,which is closely related to the economically important grape family,Vitaceae.It is widely distributed from Southern Asia to Northern Oceania.The plant parts are enriched with various bioactive compounds such as gallic acid,quercitrin,β-amyrin,β-sitosterol and lupeol,etc.Traditionally,it is used to treat itchy skin,fever,diarrhea,and body aches.The current review attempts to encompass the available literature on Leea indica with respect to its phytochemistry,traditional uses and gist of its various pharmacological activities.展开更多
The chemical constituents of essential oil from leaves of Leea longifolia Merr.were analyzed by the capillary GC-MS method.In the essential oil,28 compounds were identified,which accounted for 99.99 % of total content...The chemical constituents of essential oil from leaves of Leea longifolia Merr.were analyzed by the capillary GC-MS method.In the essential oil,28 compounds were identified,which accounted for 99.99 % of total content of the essential oil.The main chemical constituents were phenol(15.72 %),n-hexadecanoic acid(11.25 %),phenylethyl alcohol(8.25 %),octadec-9-enoic acid(7.96 %),2,3-dihydro-benzofuran(6.20 %),pentatriacontane(5.90 %),etc.展开更多
文摘Objective:To investigate the antilithiatic effect of the whole Leea macrophylla(L macrophylla) Roxb(Leeaeeae) ethanol extract in ediylene glycol-induced urolithiasis model of rats.Methods: Forty two seven weeks old male wistar albino rats were randomly divided into two major groups namely:preventive(n=18) and therapeutic(n=24).Preventive group was further subdivided into 3 groups of 6 rats namely:preventive control(PC),preventive lithiatic control(PLC) and preventive lithiatic L.macrophylla(PLLM).Similarly,therapeutic group was also subdivided into 4 groups of 6 rats namely:therapeutic control(TC),therapeutic lithiatic control(TLC).therapeutic lithitatic L macrophylla(TLLM) and therapeutic lithiatic cystone(TLCYS).The lithiasis was induced by 0.75%(v/v) ethylene glycol in the drinking water of all groups except the PC and TC groups.The urinary ionic parameters such as calcium,inorganic phosphate,oxalate,magnesium & creatinine and renal morphology were altered by ediylene glycol,which were partially recovered by 14 d preventive and almost fully recovered by 28 d therapeutic intervention trials with L macrophylla extract(500 mg/kg BW daily).Results:Significant difference on recovery was observed between preventive and dierapeutic interventional trials.Anti-urolithiatic effect of cystone was significantly(P【0.001) higher than extracts.L macrophylla extract was found nontoxic in the acute toxicity test.Conclusions:The results of this study demonstrated very promising antiurolithiatic effect of L.macrophylla extract with preventive and therapeutic treatments in this experimental condition.
基金supported by the Southeast Asia Biodiversity Research Institute,Chinese Academy of Sciences(Grant Nos.2015CASEABRIRG001 and Y4ZK111B01)the International Partnership Program of Chinese Academy of Sciences(153631KYSB20160004).
文摘We aimed at reporting the chemical constituents and antimicrobial activities of Leea aequata L.,a traditional folk medicine used in Myanmar for the treatment of wounds and skin diseases.A new neolignan,(7S,8R)-9′-O-acetylcedrusin(1),a new lactam,(3S,4S)-4-chloro-3-hydroxypiperidin-2-one(2),along with 21 known compounds,including fve lignans(3-7),four favonoid glycosides(8-11),and others(12-23),were isolated from the ethanoic extract of the aerial parts of L.aequata.The structures of the new compounds were determined by NMR,MS,and ECD spectra.For all the antimicrobial tests of the 23 compounds,only 3,4,5-trihydroxybenzoic acid ethyl ester(17)showed weak inhibitory activities against Escherichia coli and Salmonella enterica subsp.enterica.
文摘Herbal drug therapy is the most trusted system of medicine in countries like India,where people strongly believe in Ayurveda as herbs are the part of rural Indian lifestyle.Most of the diseases which have no medicine in allopathic system can be cured successfully by using traditional medicines.Leea indica,a traditional Chinese medicinal plant is the sole member of the family Leeaceae,which is closely related to the economically important grape family,Vitaceae.It is widely distributed from Southern Asia to Northern Oceania.The plant parts are enriched with various bioactive compounds such as gallic acid,quercitrin,β-amyrin,β-sitosterol and lupeol,etc.Traditionally,it is used to treat itchy skin,fever,diarrhea,and body aches.The current review attempts to encompass the available literature on Leea indica with respect to its phytochemistry,traditional uses and gist of its various pharmacological activities.
文摘The chemical constituents of essential oil from leaves of Leea longifolia Merr.were analyzed by the capillary GC-MS method.In the essential oil,28 compounds were identified,which accounted for 99.99 % of total content of the essential oil.The main chemical constituents were phenol(15.72 %),n-hexadecanoic acid(11.25 %),phenylethyl alcohol(8.25 %),octadec-9-enoic acid(7.96 %),2,3-dihydro-benzofuran(6.20 %),pentatriacontane(5.90 %),etc.
