平整机轧制力的预报对轧制过程的优化控制有着重要意义。针对平整机轧制力预测精度不高的问题,提出采用Re LU(Rectified Linear Units)激活函数的神经网络模型来预报平整机的轧制力。在对数据进行主成分分析后,得到影响轧制力的主要因素...平整机轧制力的预报对轧制过程的优化控制有着重要意义。针对平整机轧制力预测精度不高的问题,提出采用Re LU(Rectified Linear Units)激活函数的神经网络模型来预报平整机的轧制力。在对数据进行主成分分析后,得到影响轧制力的主要因素,并将其作为神经网络的输入层,将平整机轧制力作为输出层,通过使用Python语言编程进行实验,对神经网络模型隐层的相关参数及算法进行单一变量筛选,建立了保证轧制力预报精度最高的神经网络模型。实验结果表明,通过调整隐层层数、神经元数、传播算法、正则化方法,该模型能够将预测误差控制在10%以内,且该实验方法能够对不同输入参数下的平整机轧制力进行精确预报。展开更多
A "leaky gut" may be the cutting edge for the passage of toxins, antigens or bacteria into the body, and may play a pathogenic role in advanced liver cirrhosis and its complications. Plasma endotoxin levels ...A "leaky gut" may be the cutting edge for the passage of toxins, antigens or bacteria into the body, and may play a pathogenic role in advanced liver cirrhosis and its complications. Plasma endotoxin levels have been admitted as a surrogate marker of bacterial translocation and close relations of endotoxemia to hyperdynamic circulation, portal hypertension, renal, cardiac, pulmonary and coagulation disturbances have been reported. Bacterial overgrowth, increased intestinal permeability, failure to inactivate endotoxin,activated innate immunity are all likely to play a role in the pathological states of bacterial translocation. Therapeutic approach by management of the gut-liver axis by antibiotics, probiotics, synbiotics, prebiotics and their combinations may improve the clinical course of cirrhotic patients. Special concern should be paid on anti-endotoxin treatment. Adequate management of the gut-liver axis may be effective for prevention of liver cirrhosis itself by inhibiting the progression of fibrosis.展开更多
Gut flora and bacterial translocation (BT) play important roles in the pathogenesis of chronic liver disease, including cirrhosis and its complications. Intestinal bacterial overgrowth and increased bacterial transloc...Gut flora and bacterial translocation (BT) play important roles in the pathogenesis of chronic liver disease, including cirrhosis and its complications. Intestinal bacterial overgrowth and increased bacterial translocation of gut flora from the intestinal lumen predispose patients to bacterial infections, major complications and also play a role in the pathogenesis of chronic liver disorders. Levels of bacterial lipopolysaccharide, a component of gram-negative bacteria, are increased in the portal and/or systemic circulation in several types of chronic liver disease. Impaired gut epithelial integrity due to alterations in tight junction proteins may be the pathological mechanism underlying bacterial translocation. Preclinical and clinical studies over the last decade have suggested a role for BT in the pathogenesis of nonalcoholic steatohepatitis (NASH). Bacterial overgrowth, immune dysfunction, alteration of the luminal factors, and altered intestinal permeability are all involved in the pathogenesis of NASH and its complications. A better understanding of the cell-specific recognition and intracellular signaling events involved in sensing gut-derived microbes will help in the development of means to achieve an optimal balance in the gut-liver axis and ameliorate liver diseases. These may suggest new targets for potential therapeutic interventions for the treatment of NASH. Here, we review some of the mechanisms connecting BT and NASH and potential therapeutic developments.展开更多
Palaeoskapha sichuanensis gen. et sp. nov. of Menispermaceae is described here for the first time based on a well preserved fossil fruit. The specimen was found in the Relu Formation of western Sichuan, West China. Th...Palaeoskapha sichuanensis gen. et sp. nov. of Menispermaceae is described here for the first time based on a well preserved fossil fruit. The specimen was found in the Relu Formation of western Sichuan, West China. The specimen, straight, boat-shaped endocarp with large ventral condyle, clearly belongs to the tribe Tinosporeae. The wide aperture of the double condyle, combined with a whole shape not deeply invaginated, indicates a genus different from what was already known to science for this tribe. This fossil widens the distribution of the tribe during Eocene from North America and Europe to Asia, where it was formerly unknown.展开更多
Western diet(rich in highly refined sugar and fat)can induce a range of metabolic dysfunctions in animals and humans,including neuroinflammation and cognitive function decline.Neuroinflammation and cognitive impairmen...Western diet(rich in highly refined sugar and fat)can induce a range of metabolic dysfunctions in animals and humans,including neuroinflammation and cognitive function decline.Neuroinflammation and cognitive impairment,two critical pathological characteristics of Alzheimer’s disease,have been closely associated with microbial alteration via the gut-brain axis.Thus,the present study aimed to investigate the influence of 2-O-β-D-glucopyranosyl-L-ascorbic acid(AA-2βG)isolated from the fruits of Lycium barbarum on preventing the high-fructose diet(HFrD)induced neuroinflammation in mice.It was found that AA-2βG prevented HFr D-induced cognitive deficits.AA-2βG also predominantly enhanced the gut barrier integrity,decreased lipopolysaccharide entry into the circulation,which subsequently countered the activation of glial cells and neuroinflammatory response.These beneficial effects were transmissible by horizontal fecal microbiome transplantation,transferring from AA-2βG fed mice to HFr D fed mice.Additionally,AA-2βG exerted neuroprotective effects involving the enrichment of Lactobacillus and Akkermansia,potentially beneficial intestinal bacteria.The present study provided the evidence that AA-2βG could improve indices of cognition and neuroinflammmation via modulating gut dybiosis and preventing leaky gut.As a potential functional food ingredient,AA-2βG may be applied to attenuate neuroinflammation associated with Western-style diets.展开更多
We propose a single-beam leaky-wave antenna(LWA) with a wide-scanning angle and a high-scanning rate based on spoof surface plasmon polariton(SSPP) in this paper. The SSPP transmission line(TL) is etched with periodic...We propose a single-beam leaky-wave antenna(LWA) with a wide-scanning angle and a high-scanning rate based on spoof surface plasmon polariton(SSPP) in this paper. The SSPP transmission line(TL) is etched with periodically arranged circular patches, which converts the slow-wave mode into the fast-wave region for radiation. The proposed LWA is designed, fabricated, and tested. The simulated results imply that the proposed LWA not only achieves a high radiation efficiency of about 81.4%, and a high scanning rate of 12.12, but also has a large scanning angle of 176° over a narrow operation bandwidth of 8.3-9.6 GHz(for |S_(11)| <-10 dB). In addition, the simulated average gain of the LWA can reach as high as 10.9 d Bi. The measured scanning angle range is 175° in the operation band of 8.2-9.6 GHz, and the measured average gain is 10.6 dBi. The experimental results are consistent with the simulation, validating its performance. An antenna with high radiation efficiency, wide scanning angle range, and high scanning rate has great potential for application in radar and wireless communication systems.展开更多
Internet access is becoming even more heterogeneous, including different wireless backhauling links, with Ka-band satellites as a possible alternative. Since communication path is unknown a priori, adoption of PEP sol...Internet access is becoming even more heterogeneous, including different wireless backhauling links, with Ka-band satellites as a possible alternative. Since communication path is unknown a priori, adoption of PEP solutions to optimize TCP performance over satellite is discouraged to allow dynamic network reconfigurations. To opposite, an endto-end TCP performance evaluation on such a challenging scenario, with possible large latency and transmission losses, is herein considered of paramount importance. Several TCP variants exist to tackle different aspects of communication networks. In Linux, the different TCP congestion control schemes differ from the theoretical formulations and RFC specifications, introducing a varying set of optimizations and options. This aspect makes difficult to identify a standard/reference TCP version for the proposed scenario, while testing with the real protocol stacks is deemed necessary to obtain consistent results. In addition, an innovative end-to-end TCP, namely TCP Wave, is introduced to replace the traditional window-based transmission with a burst-based strategy, representing a valid alternative to Linux TCP. To offer a fair, realistic and comprehensive evaluation, we configured a simulation setup where different Linux TCPs can be run within ns-3 network simulator and compared with TCP Wave.展开更多
The laminar flow through a leaky tube is investigated, and the momentum and conservation of energy equations are solved analytically. By using the Hagen-Poiseuille velocity profile and defining unknown functions for t...The laminar flow through a leaky tube is investigated, and the momentum and conservation of energy equations are solved analytically. By using the Hagen-Poiseuille velocity profile and defining unknown functions for the axial and radial velocity compo- nents, the pressure and mass transfer equations are obtained, and their profiles are plotted according to different parameters. The results indicate that the axial velocity, the radial velocity, the mass transfer parameter, and the pressure in the tube decrease as the fluid moves along the tube.展开更多
文摘平整机轧制力的预报对轧制过程的优化控制有着重要意义。针对平整机轧制力预测精度不高的问题,提出采用Re LU(Rectified Linear Units)激活函数的神经网络模型来预报平整机的轧制力。在对数据进行主成分分析后,得到影响轧制力的主要因素,并将其作为神经网络的输入层,将平整机轧制力作为输出层,通过使用Python语言编程进行实验,对神经网络模型隐层的相关参数及算法进行单一变量筛选,建立了保证轧制力预报精度最高的神经网络模型。实验结果表明,通过调整隐层层数、神经元数、传播算法、正则化方法,该模型能够将预测误差控制在10%以内,且该实验方法能够对不同输入参数下的平整机轧制力进行精确预报。
文摘A "leaky gut" may be the cutting edge for the passage of toxins, antigens or bacteria into the body, and may play a pathogenic role in advanced liver cirrhosis and its complications. Plasma endotoxin levels have been admitted as a surrogate marker of bacterial translocation and close relations of endotoxemia to hyperdynamic circulation, portal hypertension, renal, cardiac, pulmonary and coagulation disturbances have been reported. Bacterial overgrowth, increased intestinal permeability, failure to inactivate endotoxin,activated innate immunity are all likely to play a role in the pathological states of bacterial translocation. Therapeutic approach by management of the gut-liver axis by antibiotics, probiotics, synbiotics, prebiotics and their combinations may improve the clinical course of cirrhotic patients. Special concern should be paid on anti-endotoxin treatment. Adequate management of the gut-liver axis may be effective for prevention of liver cirrhosis itself by inhibiting the progression of fibrosis.
基金Supported by Immuron, Nasvax, Plantylight, Desert Labs,Teva Pharmaceutical and ENZO Biochem
文摘Gut flora and bacterial translocation (BT) play important roles in the pathogenesis of chronic liver disease, including cirrhosis and its complications. Intestinal bacterial overgrowth and increased bacterial translocation of gut flora from the intestinal lumen predispose patients to bacterial infections, major complications and also play a role in the pathogenesis of chronic liver disorders. Levels of bacterial lipopolysaccharide, a component of gram-negative bacteria, are increased in the portal and/or systemic circulation in several types of chronic liver disease. Impaired gut epithelial integrity due to alterations in tight junction proteins may be the pathological mechanism underlying bacterial translocation. Preclinical and clinical studies over the last decade have suggested a role for BT in the pathogenesis of nonalcoholic steatohepatitis (NASH). Bacterial overgrowth, immune dysfunction, alteration of the luminal factors, and altered intestinal permeability are all involved in the pathogenesis of NASH and its complications. A better understanding of the cell-specific recognition and intracellular signaling events involved in sensing gut-derived microbes will help in the development of means to achieve an optimal balance in the gut-liver axis and ameliorate liver diseases. These may suggest new targets for potential therapeutic interventions for the treatment of NASH. Here, we review some of the mechanisms connecting BT and NASH and potential therapeutic developments.
文摘Palaeoskapha sichuanensis gen. et sp. nov. of Menispermaceae is described here for the first time based on a well preserved fossil fruit. The specimen was found in the Relu Formation of western Sichuan, West China. The specimen, straight, boat-shaped endocarp with large ventral condyle, clearly belongs to the tribe Tinosporeae. The wide aperture of the double condyle, combined with a whole shape not deeply invaginated, indicates a genus different from what was already known to science for this tribe. This fossil widens the distribution of the tribe during Eocene from North America and Europe to Asia, where it was formerly unknown.
基金the financial support from the Key Research and Development Program of Ningxia Hui Autonomous Region of China(2021BEF02008)the National Natural Science Foundation of China(32272330)the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘Western diet(rich in highly refined sugar and fat)can induce a range of metabolic dysfunctions in animals and humans,including neuroinflammation and cognitive function decline.Neuroinflammation and cognitive impairment,two critical pathological characteristics of Alzheimer’s disease,have been closely associated with microbial alteration via the gut-brain axis.Thus,the present study aimed to investigate the influence of 2-O-β-D-glucopyranosyl-L-ascorbic acid(AA-2βG)isolated from the fruits of Lycium barbarum on preventing the high-fructose diet(HFrD)induced neuroinflammation in mice.It was found that AA-2βG prevented HFr D-induced cognitive deficits.AA-2βG also predominantly enhanced the gut barrier integrity,decreased lipopolysaccharide entry into the circulation,which subsequently countered the activation of glial cells and neuroinflammatory response.These beneficial effects were transmissible by horizontal fecal microbiome transplantation,transferring from AA-2βG fed mice to HFr D fed mice.Additionally,AA-2βG exerted neuroprotective effects involving the enrichment of Lactobacillus and Akkermansia,potentially beneficial intestinal bacteria.The present study provided the evidence that AA-2βG could improve indices of cognition and neuroinflammmation via modulating gut dybiosis and preventing leaky gut.As a potential functional food ingredient,AA-2βG may be applied to attenuate neuroinflammation associated with Western-style diets.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 62171460 and 61801508)the Natural Science Basic Research Program of Shaanxi Province, China (Grant Nos. 2020JM-350, 20200108, 20210110, and 2020022)the Postdoctoral Innovative Talents Support Program of China (Grant Nos. BX20180375, 2019M653960, and 2021T140111)。
文摘We propose a single-beam leaky-wave antenna(LWA) with a wide-scanning angle and a high-scanning rate based on spoof surface plasmon polariton(SSPP) in this paper. The SSPP transmission line(TL) is etched with periodically arranged circular patches, which converts the slow-wave mode into the fast-wave region for radiation. The proposed LWA is designed, fabricated, and tested. The simulated results imply that the proposed LWA not only achieves a high radiation efficiency of about 81.4%, and a high scanning rate of 12.12, but also has a large scanning angle of 176° over a narrow operation bandwidth of 8.3-9.6 GHz(for |S_(11)| <-10 dB). In addition, the simulated average gain of the LWA can reach as high as 10.9 d Bi. The measured scanning angle range is 175° in the operation band of 8.2-9.6 GHz, and the measured average gain is 10.6 dBi. The experimental results are consistent with the simulation, validating its performance. An antenna with high radiation efficiency, wide scanning angle range, and high scanning rate has great potential for application in radar and wireless communication systems.
文摘Internet access is becoming even more heterogeneous, including different wireless backhauling links, with Ka-band satellites as a possible alternative. Since communication path is unknown a priori, adoption of PEP solutions to optimize TCP performance over satellite is discouraged to allow dynamic network reconfigurations. To opposite, an endto-end TCP performance evaluation on such a challenging scenario, with possible large latency and transmission losses, is herein considered of paramount importance. Several TCP variants exist to tackle different aspects of communication networks. In Linux, the different TCP congestion control schemes differ from the theoretical formulations and RFC specifications, introducing a varying set of optimizations and options. This aspect makes difficult to identify a standard/reference TCP version for the proposed scenario, while testing with the real protocol stacks is deemed necessary to obtain consistent results. In addition, an innovative end-to-end TCP, namely TCP Wave, is introduced to replace the traditional window-based transmission with a burst-based strategy, representing a valid alternative to Linux TCP. To offer a fair, realistic and comprehensive evaluation, we configured a simulation setup where different Linux TCPs can be run within ns-3 network simulator and compared with TCP Wave.
文摘The laminar flow through a leaky tube is investigated, and the momentum and conservation of energy equations are solved analytically. By using the Hagen-Poiseuille velocity profile and defining unknown functions for the axial and radial velocity compo- nents, the pressure and mass transfer equations are obtained, and their profiles are plotted according to different parameters. The results indicate that the axial velocity, the radial velocity, the mass transfer parameter, and the pressure in the tube decrease as the fluid moves along the tube.
