目的 研究妊娠期糖尿病(GDM)患者血清C-C基序趋化因子配体2(CCL2)、脂质运载蛋白-2(LCN2)水平与糖脂代谢及胰岛素抵抗的相关性。方法 回顾性选取2021年6月至2023年6月在苏州大学附属张家港医院确诊的98例GDM患者作为病例组,选择同期来院...目的 研究妊娠期糖尿病(GDM)患者血清C-C基序趋化因子配体2(CCL2)、脂质运载蛋白-2(LCN2)水平与糖脂代谢及胰岛素抵抗的相关性。方法 回顾性选取2021年6月至2023年6月在苏州大学附属张家港医院确诊的98例GDM患者作为病例组,选择同期来院的98名健康妊娠孕妇作为对照组。收集两组孕妇的一般临床资料[孕周、孕次、孕前身体质量指数(BMI)、收缩压、舒张压、总胆固醇、甘油三酯、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、餐后1 h血糖(1 h PG)、餐后2 h血糖(2 h PG)、空腹胰岛素(FINS)、糖化血红蛋白(GHb)、稳态模型评估胰岛素抵抗指数(HOMA-IR)];比较对照组和病例组血清CCL2和LCN2表达水平;采用多因素Logistic回归分析对影响GDM的因素进行分析;采用Pearson相关性分析对血清CCL2和LCN2与糖脂代谢及胰岛素抵抗相关指标的相关性进行分析;采用受试者操作特征(ROC)曲线分析血清标志物CCL2、LCN2对GDM患者的诊断价值。结果 两组孕妇的年龄、孕周、孕次等比较,差异均无统计学意义(P > 0.05)。病例组的甘油三酯、总胆固醇、LDL-C、FBG、1 h PG、2 h PG、GHb、FINS、HOMA-IR均显著高于对照组,HDL-C显著低于对照组,差异均有统计学意义(P<0.05)。病例组的血清CCL2、LCN2水平分别为(32.46±6.87)、(23.61±6.26) pg/mL,均显著高于对照组[(26.31±4.37)、(16.78±4.34) pg/m L],差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,血清LDL-C、FINS、甘油三酯、总胆固醇、HOMA-IR、CCL2、LCN2均为GDM的危险因素(P<0.05),而HDL-C是GDM的保护因素(P<0.05)。Pearson相关性分析结果显示,血清CCL2、LCN2水平与FBG、1 h PG、2 h PG、FINS、LDL-C、Hb Alc、甘油三酯、总胆固醇、HOMA-IR均呈正相关(P<0.05),与HDL-C呈负相关(P<0.05)。血清CCL2、LCN2二者联合诊断GDM患者的曲线下面积(AUC)最高,显著高于CCL2、LCN2单独诊断(P<0.05)。结论 GDM患者血清中CCL2和LCN2的表达水平均明显升高,二者与糖脂代谢紊乱和胰岛素抵抗存在密切关联,可作为临床诊断GDM的指标。展开更多
Lipocalin-2(LCN2)is a member of the lipocalin superfamily with multiple functions and can participate in the transport of a variety of small lipophilic ligands in vivo.LCN2 is significantly expressed in various tumors...Lipocalin-2(LCN2)is a member of the lipocalin superfamily with multiple functions and can participate in the transport of a variety of small lipophilic ligands in vivo.LCN2 is significantly expressed in various tumors and plays an important role in regulating tumor cell proliferation,invasion,and metastasis.The specific actions of LCN2 in tumors may vary depending on the particular type of cancer involved.In this review,we provide an extensive overview of the transcriptional and post-transcriptional regulation of LCN2 in health and disease.Furthermore,we summarize the impact of LCN2 dysregulation in a broad range of tumors.Lastly,we examine the mechanisms of action of LCN2 during tumorigenesis,progression,and metastasis.Understanding the complex relationships between LCN2 and tumor development,progression,and metastasis is vital for advancing our knowledge of cancer biology,developing biomarkers for diagnosis and clinical decision-making,and creating therapeutic strategies to improve the management of patients with cancer.展开更多
文摘目的 研究妊娠期糖尿病(GDM)患者血清C-C基序趋化因子配体2(CCL2)、脂质运载蛋白-2(LCN2)水平与糖脂代谢及胰岛素抵抗的相关性。方法 回顾性选取2021年6月至2023年6月在苏州大学附属张家港医院确诊的98例GDM患者作为病例组,选择同期来院的98名健康妊娠孕妇作为对照组。收集两组孕妇的一般临床资料[孕周、孕次、孕前身体质量指数(BMI)、收缩压、舒张压、总胆固醇、甘油三酯、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、餐后1 h血糖(1 h PG)、餐后2 h血糖(2 h PG)、空腹胰岛素(FINS)、糖化血红蛋白(GHb)、稳态模型评估胰岛素抵抗指数(HOMA-IR)];比较对照组和病例组血清CCL2和LCN2表达水平;采用多因素Logistic回归分析对影响GDM的因素进行分析;采用Pearson相关性分析对血清CCL2和LCN2与糖脂代谢及胰岛素抵抗相关指标的相关性进行分析;采用受试者操作特征(ROC)曲线分析血清标志物CCL2、LCN2对GDM患者的诊断价值。结果 两组孕妇的年龄、孕周、孕次等比较,差异均无统计学意义(P > 0.05)。病例组的甘油三酯、总胆固醇、LDL-C、FBG、1 h PG、2 h PG、GHb、FINS、HOMA-IR均显著高于对照组,HDL-C显著低于对照组,差异均有统计学意义(P<0.05)。病例组的血清CCL2、LCN2水平分别为(32.46±6.87)、(23.61±6.26) pg/mL,均显著高于对照组[(26.31±4.37)、(16.78±4.34) pg/m L],差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,血清LDL-C、FINS、甘油三酯、总胆固醇、HOMA-IR、CCL2、LCN2均为GDM的危险因素(P<0.05),而HDL-C是GDM的保护因素(P<0.05)。Pearson相关性分析结果显示,血清CCL2、LCN2水平与FBG、1 h PG、2 h PG、FINS、LDL-C、Hb Alc、甘油三酯、总胆固醇、HOMA-IR均呈正相关(P<0.05),与HDL-C呈负相关(P<0.05)。血清CCL2、LCN2二者联合诊断GDM患者的曲线下面积(AUC)最高,显著高于CCL2、LCN2单独诊断(P<0.05)。结论 GDM患者血清中CCL2和LCN2的表达水平均明显升高,二者与糖脂代谢紊乱和胰岛素抵抗存在密切关联,可作为临床诊断GDM的指标。
基金supported by the Program for Science Technology and Innovation Committee of Shenzhen(2021N062-JCYJ20210324115408023)Guangdong High-Level Hospital Construction Fund,Shenzhen High-Level Hospital Construction Fund。
文摘Lipocalin-2(LCN2)is a member of the lipocalin superfamily with multiple functions and can participate in the transport of a variety of small lipophilic ligands in vivo.LCN2 is significantly expressed in various tumors and plays an important role in regulating tumor cell proliferation,invasion,and metastasis.The specific actions of LCN2 in tumors may vary depending on the particular type of cancer involved.In this review,we provide an extensive overview of the transcriptional and post-transcriptional regulation of LCN2 in health and disease.Furthermore,we summarize the impact of LCN2 dysregulation in a broad range of tumors.Lastly,we examine the mechanisms of action of LCN2 during tumorigenesis,progression,and metastasis.Understanding the complex relationships between LCN2 and tumor development,progression,and metastasis is vital for advancing our knowledge of cancer biology,developing biomarkers for diagnosis and clinical decision-making,and creating therapeutic strategies to improve the management of patients with cancer.
