Background: To examine the differences in prevalence of respiratory distress syndrome, early-onset sepsis and jaundice, between late preterm infants versus term infants in Ecuadorian newborns. Methods: Study design: E...Background: To examine the differences in prevalence of respiratory distress syndrome, early-onset sepsis and jaundice, between late preterm infants versus term infants in Ecuadorian newborns. Methods: Study design: Epidemiological, observational, and cross-sectional, with two cohorts of patients. Settings: IESS Quito Sur Hospital at Quito, Ecuador, from February to April of 2020. Participants: This study included 204 newborns, 102 preterm infants, 102 term infants. Results: There are significant differences between late preterm infants and term infants, with a p-value of 0.000 in the prevalence of early sepsis, 70.59% vs. 35.29%. In respiratory distress syndrome between late and term premature infants, significant differences were observed with a p-value of 0.000, the proportion being 55.58% vs. 24.51% respectively. The prevalence of jaundice is higher in term infants with a p value of 0.002, 72.55%, versus 51.96% in late preterm infants, and the mean value of bilirubins in mg/dL was higher in term infants 14.32 versus 12.33 in late preterm infants;this difference is statistically significant with a p value of 0.004. Admission to the NICU is more frequent in late preterm infants with a p-value of 0.000, being 42.16% for late preterm infants vs. 7.84% in term infants;the mean of the hospital days with p-value 0.005, was higher in late preterm infants 4.97 days vs. 3.55 days for term newborns. Conclusion: Due to the conditions of their immaturity, late preterm infants are 2.86 times more likely to present early sepsis than full-term newborns. It is shown that late preterm infants are 2.69 times more likely to have respiratory distress syndrome compared to term infants, therefore, late preterm infants have a longer hospital stay of 4.97 days versus 3.55 days in term infants. Jaundice and mean bilirubin levels are higher in term infants due to blood group incompatibility and insufficient breastfeeding.展开更多
Objective To investigate the current enteral feeding practices in hospitalized late preterm infants in the Beijing area of China. Methods A multi-center, cross-sectional study was conducted. Infants born after 34 week...Objective To investigate the current enteral feeding practices in hospitalized late preterm infants in the Beijing area of China. Methods A multi-center, cross-sectional study was conducted. Infants born after 34 weeks and before 37 weeks of gestation were enrolled from 25 hospitals in the Beijing area of China from October 2015 to October 2017. Data on enteral feeding practices were collected and analyzed. Results A total of 1,463 late preterm infants were enrolled, with a mean gestational age（GA） of 35.6（34.9, 36.1） weeks. The percentage of exclusive breastfeeding was 4.5% at the initiation of enteral feeding but increased to 14.4% at discharge. When human milk was not available, most infants（46.1%） were fed with preterm infant formula. The rate of exclusive human milk feeding in infants born at 34 weeks gestation was higher than at discharge（21.1% of infants born at 34 weeks＇ GA versus 12.1% of infants born at 35 weeks＇ GA versus 12.3% of infants born at 36 weeks＇ GA, P 〈 0.001）. Only 28.4% of late preterm infants achieved full enteral feeding at discharge, and only 19.2% achieved 120 kcal/（kg·d） by enteral feeding at discharge. Importantly, 40.5% of infants did not regain the birth weight at discharge. Conclusion Enteral feeding support of late preterm infants has not been standardized to achieve optimal growth. Moreover, the human milk feeding rate was low, and many late preterm infants did not achieve the goal of enteral feeding and failed to regain birth weight at the time of discharge. More aggressive enteral feedings protocols are needed to promote human milk feeding and optimize growth for late preterm infants.展开更多
Motor development at late preterm infants has significant importance as it composes the picture of the severe evidences of motor impairments or other developmental difficulties. Early detection is crucial as early int...Motor development at late preterm infants has significant importance as it composes the picture of the severe evidences of motor impairments or other developmental difficulties. Early detection is crucial as early intervention is the unique immediate solution option to catch up the developmental milestones. Method: Α systematic search for scientific articles of the decade 2010-2020 investigating the motor profile of late preterm infants was conducted. Results: The search identified 9 studies, many of which highlighted the risk of motor and developmental delays even at 36 months of age. Conclusions: The stability of motor and developmental delays indicates the need of further investigation at a later age and intervention to avoid possible academic difficulties.展开更多
Objective: We aimed to compare the perinatal outcomes in late preterm spontaneous and indicated birth neonates. Methods: We studied 289 late preterm births, classified as either aspontaneous late preterm birth (sLPTB)...Objective: We aimed to compare the perinatal outcomes in late preterm spontaneous and indicated birth neonates. Methods: We studied 289 late preterm births, classified as either aspontaneous late preterm birth (sLPTB) group (preterm labor with intact membranes and preterm premature rupture of membranes) or an indicated late preterm birth (iLPTB) group (hypertensive disorder in pregnancy, placental causes, and maternal diseases), according to the delivery indication. We then compared the maternal and neonatal characteristics and perinatal outcomes, including the Apgar score, admission to the neonatal intensive care unit (NICU) or special care nursery (SCN), duration of NICU stay, and the rate of composite morbidity (antibiotic use, hypoglycemia, hypocalcemia, hyperbilirubinemia requiring phototherapy, respiratory support, and respiratory distress syndrome). Results: A total of 198 neonates were in the sLPTB group and 91 were in the iLPTB group. In spite of greater gestational age at the time of delivery in the iLPTB group, the mean birth weight was lower than that in the sLPTB group. Additionally, the iLPTB group showed lower Apgar scores, and higher rates of NICU or SCN admission, respiratory support, and hypoglycemia, but there was no difference in the rate of composite morbidity between the two groups. Conclusion: iLPTB neonates had lower birth weights despite greater gestational age than those in the sLPTB group, but there was no difference in the rate of composite morbidity between the two groups.展开更多
Purpose: To investigate the relationship between preterm delivery and developmental outcomes in children born at 34 - 36 weeks of gestation (late preterm period). Methods: This study reviewed the cases of singleton la...Purpose: To investigate the relationship between preterm delivery and developmental outcomes in children born at 34 - 36 weeks of gestation (late preterm period). Methods: This study reviewed the cases of singleton late preterm children and full-term (38 - 40 weeks of gestation) children born at Showa University Hospital. The developmental outcomes at 3 years of age were assessed based on the results of questionnaires sent to the families by mail. In addition, the incidence of developmental delays was compared between the late preterm and full-term children. In the full-term control group, perinatal characteristics (neonatal gender, Apgar score, Cesarean delivery, birth weight < 10th percentile, birth weight < 3rd percentile) were matched with those of the late preterm cases. We compared categorical variables using Fisher’s exact test. For variables with a non-normal distribution, Welch’s t-test was applied. A p-value of <0.05 was considered to be statistically significant. Results: The rate of return of the questionnaires was 25.9% (121) among the cases and 25.8% (163) among the controls. The frequency of developmental delays was 6.6% among the cases, compared with 4.3% among the controls. Conclusions: Matching the perinatal characteristics of the subjects, the frequency of developmental delays was similar between the two groups.展开更多
Background and Objectives:Feeding intolerance(FI)is a common problem in late preterm infants(34 weeks≤gestational age<37 weeks).This study aimed to evaluate the efficacy and safety of phentolamine combined with B ...Background and Objectives:Feeding intolerance(FI)is a common problem in late preterm infants(34 weeks≤gestational age<37 weeks).This study aimed to evaluate the efficacy and safety of phentolamine combined with B vitamins in treating FI in late preterm infants and to explore its effects on gastrointestinal symptoms,inflammation and complications.Methods and Study Design:We randomly assigned 118 late preterm infants with FI to a treatment group(n=56)or a control group(n=62).The treatment group received intravenous phentolamine and intramuscular B vitamins,whereas the control group received basic treatment only.We measured the time of disappearance of gastrointestinal symptoms,the time of basal attainment,the time of hospitalisation,the incidence of complications,the concentrations of inflammatory markers and the overall effective rate of treatment.Results:The treatment group had a shorter duration of gastrointestinal symptoms than did the control group(p<0.01).The treatment group also had lower concentrations of inflammatory markers and a higher overall effective rate than did the control group(p<0.05).There was no difference between the two groups in the time of hospitalisation,basal attainment,weight recovery and the incidence of complications(p>0.05).Conclusions:Phentolamine and B vitamins can reduce gastrointestinal symptoms and inflammation in late preterm infants with FI but do not affect the occurrence of complications.展开更多
目的 探究不同喂养方式与矫正月龄0~5月龄晚期早产儿(出生胎龄34~36周)生长发育的关系。方法 采用多阶段分层随机抽样,于2018年2月—2020年1月在华东、华北、华中、华南、西南、西北和东北7个区域共计28个调查点开展抽样调查,共纳入矫...目的 探究不同喂养方式与矫正月龄0~5月龄晚期早产儿(出生胎龄34~36周)生长发育的关系。方法 采用多阶段分层随机抽样,于2018年2月—2020年1月在华东、华北、华中、华南、西南、西北和东北7个区域共计28个调查点开展抽样调查,共纳入矫正月龄0~5月龄纯母乳喂养晚期早产儿48例和添加配方奶喂养晚期早产儿53例。由调查员采用自制问卷面对面调查早产儿母亲或其它主要监护人,收集婴儿基本特征和喂养情况等信息,测量婴儿的身长、体重和头围数据。以纯母乳喂养晚期早产儿的矫正月龄和性别为匹配变量,通过倾向性评分匹配0~5月龄纯母乳喂养足月儿48例作为参照,评估不同喂养方式晚期早产儿与纯母乳喂养足月儿生长发育的差异。采用Z评分和体重增长速率评价婴儿生长发育状况,采用方差分析比较3组婴儿的生长发育情况,采用多重线性回归调整潜在混杂因素后分析喂养方式对晚期早产儿生长发育的影响。结果 矫正月龄0~5月龄纯母乳喂养晚期早产儿与添加配方奶喂养晚期早产儿的年龄别身长Z评分(length for age Z-score, LAZ)、年龄别体重Z评分(weight for age Z-score, WAZ)、身长别体重Z评分(weight for length Z-score, WLZ)、年龄别体质指数Z评分(body mass index for age Z-score, BAZ)以及体重增长速率差异无统计学意义(P>0.05);纯母乳喂养晚期早产儿与纯母乳喂养足月儿的LAZ、WAZ、WLZ、BAZ以及体重增长速率差异无统计学意义(P>0.05);但添加配方奶喂养晚期早产儿的WAZ和年龄别头围Z评分(head circumference for age Z-score, HCZ)分别比纯母乳喂养足月儿高0.41(P=0.03)和0.44(P=0.02),两组间LAZ、WLZ、BAZ和体重增长速率差异无统计学意义(P>0.05)。结论 矫正月龄0~5月龄纯母乳喂养晚期早产儿的生长发育与纯母乳喂养足月儿相似,添加配方奶喂养促进晚期早产儿体重增加,而非身长增长。展开更多
文摘Background: To examine the differences in prevalence of respiratory distress syndrome, early-onset sepsis and jaundice, between late preterm infants versus term infants in Ecuadorian newborns. Methods: Study design: Epidemiological, observational, and cross-sectional, with two cohorts of patients. Settings: IESS Quito Sur Hospital at Quito, Ecuador, from February to April of 2020. Participants: This study included 204 newborns, 102 preterm infants, 102 term infants. Results: There are significant differences between late preterm infants and term infants, with a p-value of 0.000 in the prevalence of early sepsis, 70.59% vs. 35.29%. In respiratory distress syndrome between late and term premature infants, significant differences were observed with a p-value of 0.000, the proportion being 55.58% vs. 24.51% respectively. The prevalence of jaundice is higher in term infants with a p value of 0.002, 72.55%, versus 51.96% in late preterm infants, and the mean value of bilirubins in mg/dL was higher in term infants 14.32 versus 12.33 in late preterm infants;this difference is statistically significant with a p value of 0.004. Admission to the NICU is more frequent in late preterm infants with a p-value of 0.000, being 42.16% for late preterm infants vs. 7.84% in term infants;the mean of the hospital days with p-value 0.005, was higher in late preterm infants 4.97 days vs. 3.55 days for term newborns. Conclusion: Due to the conditions of their immaturity, late preterm infants are 2.86 times more likely to present early sepsis than full-term newborns. It is shown that late preterm infants are 2.69 times more likely to have respiratory distress syndrome compared to term infants, therefore, late preterm infants have a longer hospital stay of 4.97 days versus 3.55 days in term infants. Jaundice and mean bilirubin levels are higher in term infants due to blood group incompatibility and insufficient breastfeeding.
基金supported by Science and Technology Project of Beijing Health and Family Planning Commission[2016001]the CAMS Initiative for Innovative Medicine[2016-12M-1-008]
文摘Objective To investigate the current enteral feeding practices in hospitalized late preterm infants in the Beijing area of China. Methods A multi-center, cross-sectional study was conducted. Infants born after 34 weeks and before 37 weeks of gestation were enrolled from 25 hospitals in the Beijing area of China from October 2015 to October 2017. Data on enteral feeding practices were collected and analyzed. Results A total of 1,463 late preterm infants were enrolled, with a mean gestational age（GA） of 35.6（34.9, 36.1） weeks. The percentage of exclusive breastfeeding was 4.5% at the initiation of enteral feeding but increased to 14.4% at discharge. When human milk was not available, most infants（46.1%） were fed with preterm infant formula. The rate of exclusive human milk feeding in infants born at 34 weeks gestation was higher than at discharge（21.1% of infants born at 34 weeks＇ GA versus 12.1% of infants born at 35 weeks＇ GA versus 12.3% of infants born at 36 weeks＇ GA, P 〈 0.001）. Only 28.4% of late preterm infants achieved full enteral feeding at discharge, and only 19.2% achieved 120 kcal/（kg·d） by enteral feeding at discharge. Importantly, 40.5% of infants did not regain the birth weight at discharge. Conclusion Enteral feeding support of late preterm infants has not been standardized to achieve optimal growth. Moreover, the human milk feeding rate was low, and many late preterm infants did not achieve the goal of enteral feeding and failed to regain birth weight at the time of discharge. More aggressive enteral feedings protocols are needed to promote human milk feeding and optimize growth for late preterm infants.
文摘Motor development at late preterm infants has significant importance as it composes the picture of the severe evidences of motor impairments or other developmental difficulties. Early detection is crucial as early intervention is the unique immediate solution option to catch up the developmental milestones. Method: Α systematic search for scientific articles of the decade 2010-2020 investigating the motor profile of late preterm infants was conducted. Results: The search identified 9 studies, many of which highlighted the risk of motor and developmental delays even at 36 months of age. Conclusions: The stability of motor and developmental delays indicates the need of further investigation at a later age and intervention to avoid possible academic difficulties.
文摘Objective: We aimed to compare the perinatal outcomes in late preterm spontaneous and indicated birth neonates. Methods: We studied 289 late preterm births, classified as either aspontaneous late preterm birth (sLPTB) group (preterm labor with intact membranes and preterm premature rupture of membranes) or an indicated late preterm birth (iLPTB) group (hypertensive disorder in pregnancy, placental causes, and maternal diseases), according to the delivery indication. We then compared the maternal and neonatal characteristics and perinatal outcomes, including the Apgar score, admission to the neonatal intensive care unit (NICU) or special care nursery (SCN), duration of NICU stay, and the rate of composite morbidity (antibiotic use, hypoglycemia, hypocalcemia, hyperbilirubinemia requiring phototherapy, respiratory support, and respiratory distress syndrome). Results: A total of 198 neonates were in the sLPTB group and 91 were in the iLPTB group. In spite of greater gestational age at the time of delivery in the iLPTB group, the mean birth weight was lower than that in the sLPTB group. Additionally, the iLPTB group showed lower Apgar scores, and higher rates of NICU or SCN admission, respiratory support, and hypoglycemia, but there was no difference in the rate of composite morbidity between the two groups. Conclusion: iLPTB neonates had lower birth weights despite greater gestational age than those in the sLPTB group, but there was no difference in the rate of composite morbidity between the two groups.
文摘Purpose: To investigate the relationship between preterm delivery and developmental outcomes in children born at 34 - 36 weeks of gestation (late preterm period). Methods: This study reviewed the cases of singleton late preterm children and full-term (38 - 40 weeks of gestation) children born at Showa University Hospital. The developmental outcomes at 3 years of age were assessed based on the results of questionnaires sent to the families by mail. In addition, the incidence of developmental delays was compared between the late preterm and full-term children. In the full-term control group, perinatal characteristics (neonatal gender, Apgar score, Cesarean delivery, birth weight < 10th percentile, birth weight < 3rd percentile) were matched with those of the late preterm cases. We compared categorical variables using Fisher’s exact test. For variables with a non-normal distribution, Welch’s t-test was applied. A p-value of <0.05 was considered to be statistically significant. Results: The rate of return of the questionnaires was 25.9% (121) among the cases and 25.8% (163) among the controls. The frequency of developmental delays was 6.6% among the cases, compared with 4.3% among the controls. Conclusions: Matching the perinatal characteristics of the subjects, the frequency of developmental delays was similar between the two groups.
基金Baoding Science and Technology Plan Project(Project No.2241ZF259).
文摘Background and Objectives:Feeding intolerance(FI)is a common problem in late preterm infants(34 weeks≤gestational age<37 weeks).This study aimed to evaluate the efficacy and safety of phentolamine combined with B vitamins in treating FI in late preterm infants and to explore its effects on gastrointestinal symptoms,inflammation and complications.Methods and Study Design:We randomly assigned 118 late preterm infants with FI to a treatment group(n=56)or a control group(n=62).The treatment group received intravenous phentolamine and intramuscular B vitamins,whereas the control group received basic treatment only.We measured the time of disappearance of gastrointestinal symptoms,the time of basal attainment,the time of hospitalisation,the incidence of complications,the concentrations of inflammatory markers and the overall effective rate of treatment.Results:The treatment group had a shorter duration of gastrointestinal symptoms than did the control group(p<0.01).The treatment group also had lower concentrations of inflammatory markers and a higher overall effective rate than did the control group(p<0.05).There was no difference between the two groups in the time of hospitalisation,basal attainment,weight recovery and the incidence of complications(p>0.05).Conclusions:Phentolamine and B vitamins can reduce gastrointestinal symptoms and inflammation in late preterm infants with FI but do not affect the occurrence of complications.
文摘目的 探究不同喂养方式与矫正月龄0~5月龄晚期早产儿(出生胎龄34~36周)生长发育的关系。方法 采用多阶段分层随机抽样,于2018年2月—2020年1月在华东、华北、华中、华南、西南、西北和东北7个区域共计28个调查点开展抽样调查,共纳入矫正月龄0~5月龄纯母乳喂养晚期早产儿48例和添加配方奶喂养晚期早产儿53例。由调查员采用自制问卷面对面调查早产儿母亲或其它主要监护人,收集婴儿基本特征和喂养情况等信息,测量婴儿的身长、体重和头围数据。以纯母乳喂养晚期早产儿的矫正月龄和性别为匹配变量,通过倾向性评分匹配0~5月龄纯母乳喂养足月儿48例作为参照,评估不同喂养方式晚期早产儿与纯母乳喂养足月儿生长发育的差异。采用Z评分和体重增长速率评价婴儿生长发育状况,采用方差分析比较3组婴儿的生长发育情况,采用多重线性回归调整潜在混杂因素后分析喂养方式对晚期早产儿生长发育的影响。结果 矫正月龄0~5月龄纯母乳喂养晚期早产儿与添加配方奶喂养晚期早产儿的年龄别身长Z评分(length for age Z-score, LAZ)、年龄别体重Z评分(weight for age Z-score, WAZ)、身长别体重Z评分(weight for length Z-score, WLZ)、年龄别体质指数Z评分(body mass index for age Z-score, BAZ)以及体重增长速率差异无统计学意义(P>0.05);纯母乳喂养晚期早产儿与纯母乳喂养足月儿的LAZ、WAZ、WLZ、BAZ以及体重增长速率差异无统计学意义(P>0.05);但添加配方奶喂养晚期早产儿的WAZ和年龄别头围Z评分(head circumference for age Z-score, HCZ)分别比纯母乳喂养足月儿高0.41(P=0.03)和0.44(P=0.02),两组间LAZ、WLZ、BAZ和体重增长速率差异无统计学意义(P>0.05)。结论 矫正月龄0~5月龄纯母乳喂养晚期早产儿的生长发育与纯母乳喂养足月儿相似,添加配方奶喂养促进晚期早产儿体重增加,而非身长增长。
