Sporadic or late-onset Alzheimer’s disease(LOAD)occurs in 1 of 10 people over 65 years of age and comprises 95%of all AD patients.Unlike early-onset AD,which is caused by defined single gene mutations,the mechanisms ...Sporadic or late-onset Alzheimer’s disease(LOAD)occurs in 1 of 10 people over 65 years of age and comprises 95%of all AD patients.Unlike early-onset AD,which is caused by defined single gene mutations,the mechanisms and events underlying risk for LOAD are not fully understood and no substantial disease-modifying interventions are currently available.Age is the most prominent risk factor for LOAD,and interacting age-related and LOAD-associated factors contribute to its pathogenesis.Among these factors are changes in bioenergetic cell functions,which metabolize substrates and produce energy stored in adenosine triphosphate.展开更多
Dear Editor,Sleep deprivation and loss can have detrimental effects on brain function.Among common patterns of sleep loss are delayed sleep onset(early night sleep loss,EL)and premature awakening(late night sleep loss...Dear Editor,Sleep deprivation and loss can have detrimental effects on brain function.Among common patterns of sleep loss are delayed sleep onset(early night sleep loss,EL)and premature awakening(late night sleep loss,LL).Here,we investigated the distinct impacts of EL and LL on resting-state brain activity.A total of 100 healthy students from several universities in Beijing were recruited and randomly assigned to one of three groups:EL,LL,or full sleep(FS).Restingstate functional magnetic resonance imaging(rs-fMRI)scans were conducted following the sleep manipulations.Compared to the FS group,the LL group showed abnormal low-frequency fluctuation(fALFF)in the prefrontal cortex and insula.展开更多
The Longshan orogenic belt is located in the southwestern margin of Ordos Basin at the junction zone between the Western Qinling and Northern Qilian orogenic belt.Voluminous Early Paleozoic magmatism in this area is o...The Longshan orogenic belt is located in the southwestern margin of Ordos Basin at the junction zone between the Western Qinling and Northern Qilian orogenic belt.Voluminous Early Paleozoic magmatism in this area is of key significance for determining the Early Paleozoic tectonic evolution and deep crust-mantle structure.Previous studies mainly focused on the Paleozoic granites;the coeval mafic rocks in this area are still poorly understood.A set of Late Silurian intraplate tholeiitic basalts has been discovered in Longshan area,providing key evidence for the mantle source and deep geodynamic background in this area.The Late Silurian Angou basalt has similar geochemical features as intraplate tholeiitic basalt,with high Na_(2)O/K_(2)O ratios(5.22-8.25),enriched in large ion lithophile elements and LREE.In combination with their relatively evolved Sr-Nd isotopic composition[^(87)Sr/^(86)Sr(i)=0.7128-0.7140;ε_(Nd)(t)=-5.55 to-3.40],it is suggested that it originated from decompression melting of metasomatized enriched mantle in extensional setting.These results indicate that the mantle source in the junction zone of the West Qinling-North Qilian orogenic belt evolved from depleted to enriched with the continuation of Proto-Tethys subduction from the Cambrian to the Silurian.These results are of great significance to understanding the genesis of contemporaneous granite and the crust-mantle interaction in the junction zone between the Western Qinling and Northern Qilian orogenic belt.展开更多
The Zongwulong Shan-Qinghai Nanshan tectonic belt of the northern Xizang Plateau experienced a protracted tectonica history,including the openings and closures of the Proto-and Paleo-Tethyan Oceans.Although the tecton...The Zongwulong Shan-Qinghai Nanshan tectonic belt of the northern Xizang Plateau experienced a protracted tectonica history,including the openings and closures of the Proto-and Paleo-Tethyan Oceans.Although the tectonic belt has been extensively studied,details regarding the tectonic processes involved in its development remain controversial.To better constrain the tectonic processes of this tectonic belt,we conducted detailed field geological mapping,zircon U-Pb geochronology,and whole-rock geochemical and Sr-Nd isotopic analyses.Our results show that intrusive rocks in the tectonic belt crystallized in ca.292-233 Ma,perhaps in an arc/subduction setting.Geochemical and Sr-Nd isotopic data suggest that Early Permian-Late Triassic ultramaficintermediate intrusions were sourced from the enriched mantle,whereas intermediate-acidic rocks were sourced from mixed crust-mantle.We present the tectonic model that involves:(1)Early Devonian-Early Permian intracontinental extension occurred in the northern margin of the Qaidam continent(ca.416-292 Ma);(2)Early Permian-Late Triassic northward subduction of the Paleo-Tethyan Ocean resulted in arc magmatism(ca.292-233 Ma);and(3)subsequent Late Triassic intracontinental extension(ca.233-215 Ma).Our results suggest that the Late Paleozoic-Early Mesozoic development of the Zongwulong Shan-Qinghai Nanshan was related to the opening,subduction,and slab retreat of the Paleo-Tethyan Ocean,which has key implications for the tectonic evolution of the northern Tibetan Plateau.展开更多
The Late Cretaceous Jiepailing granitoids,located at the central Nanling Range in South China,are closely associated with significant Sn-Li-Be-F polymetallic metallogeny.The Jiepailing granitoids mainly consist of gra...The Late Cretaceous Jiepailing granitoids,located at the central Nanling Range in South China,are closely associated with significant Sn-Li-Be-F polymetallic metallogeny.The Jiepailing granitoids mainly consist of granitic porphyry and zinnwaldite granite.The two granitoids have an A-type affinity,showing elevated Rb/Sr ratios and significant depletions in Ba,Sr and P.Integrated zircon and monazite U-Pb dating results suggest that granitic porphyry and zinnwaldite granite were emplaced at~89 Ma and~94 Ma,respectively.The low Ce^(4+)/Ce^(3+)ratios of the Jiepailing granitoids,together with significant negative Eu anomalies of the zircons,indicate that their formation occurred under conditions of reduced oxygen fugacity.Through the analysis of zircon Hf-O and whole-rock Nd isotopes,it has been determined that both stages of the Jiepailing granitoids originated in the lower-middle Mesoproterozoic crustal basement[ε_(Nd)(t)=−5.33 to−4.96,t^(C)_(DM)(Nd)=1289-1234 Ma,ε_(Hf)(t)=−4.13 to+2.22,t^(C)_(DM)(Hf)=1418-1015 Ma andδ^(18)O_(Zrc)=6.33‰-7.72‰],with the involvement of mantle-derived materials.Both granitic porphyry and zinnwaldite granite exhibit elevated concentrations of fluorine(F),with the positive correlation between F and Sn emphasizing the crucial role of high F sources in tin mineralization.Drawing upon the study of the Late Cretaceous magma systems in southern Hunan and through comparison with the mineralized granites observed in coastal regions during the Late Cretaceous,a genetic model for the mineralized granites in the Nanling region is developed.When the Paleo-Pacific Plate retreated to the coastal region,the continental crust in southern China underwent extensional thinning and asthenospheric upwelling due to gravitational collapse.Such processes resulted in the partial melting of the middle-lower crustal metamorphic sedimentary basement and the subsequent formation of F-rich granitic magmas,related to tin mineralization.展开更多
Excellent progress has been made in the last few decades in the cure rates of pediatric malignancies,with more than 80%of children with cancer who have access to contemporary treatment being cured.However,the therapie...Excellent progress has been made in the last few decades in the cure rates of pediatric malignancies,with more than 80%of children with cancer who have access to contemporary treatment being cured.However,the therapies responsible for this survival can also produce adverse physical and psychological long-term outcomes,referred to as late effects,which appear months to years after the completion of cancer treatment.Research has shown that 60%to 90%of childhood cancer survivors(CCSs)develop one or more chronic health conditions,and 20%to 80%of survivors experience severe or life-threatening complications during adulthood.Therefore,understanding the late side effects of such treatments is important to improve the health and quality of life of the growing population of CCSs.展开更多
A relatively well-preserved rodent fossil,including its incisors,cheek teeth,and postcranial skeleton,was collected from the Baiyin Obo in Siziwang Banner,Nei Mongol.A multifaceted research approach was undertaken in ...A relatively well-preserved rodent fossil,including its incisors,cheek teeth,and postcranial skeleton,was collected from the Baiyin Obo in Siziwang Banner,Nei Mongol.A multifaceted research approach was undertaken in this study to conduct a comprehensive analysis on the newly discovered specimen.Based on a morphological comparison,the new specimen was identified as Hulgana cf.H.ertnia within the Ischyromyidae family.Incisive enamel microstructure analysis revealed the typical pauciserial enamel structure of Hulgana.Bone histological analysis indicates that the specimen represents a juvenile individual,which is consistent with the ontogenetic stage indicated by dental developmental stage and wear pattern.The application of geometric morphometrics to the calcaneus and bone histology of the femur and phalanx further substantiates the taxonomic classification of Hulgana as a terrestrial and cursorial rodent,exhibiting a degree of fossorial ability.This classification is analogous to that of certain extant cricetids and ground squirrels.展开更多
The Ordovician-Silurian transition was marked by extensive volcanic activity globally.In South China,intensive volcanism was documented by abundant ash layers in strata,but the origins and tectonic settings of these a...The Ordovician-Silurian transition was marked by extensive volcanic activity globally.In South China,intensive volcanism was documented by abundant ash layers in strata,but the origins and tectonic settings of these ashes remain controversial.This study presents the stratigraphic distribution of volcanic ash layers,zircon trace element and Hf isotope data from the Wanhe Section in the southwestern Yangtze Shelf,providing insights into the tectonic setting and the origin of the parent magmas.The results suggest that volcanic ashes in the southwestern Yangtze Shelf primarily originated from arc magmatism in the Wuyi-Yunkai Orogen,with a mixed source from mantle and crust.The findings corroborate the hypothesis that the Late Ordovician–Silurian Wuyi-Yunkai Orogen in South China represents a collisional orogenic belt.展开更多
In the rice–rapeseed cropping system in the Yangtze River Basin,late rapeseed sowing increases lodging.To identify the mechanisms of reduced lodging resistance,a two-year field experiment compared four rapeseed culti...In the rice–rapeseed cropping system in the Yangtze River Basin,late rapeseed sowing increases lodging.To identify the mechanisms of reduced lodging resistance,a two-year field experiment compared four rapeseed cultivars with differing lodging resistances under normal and late sowing.Rapid stem elongation during bolting in late-sown rapeseed reduced stem plumpness,vascular bundle development,and lignin accumulation,weakening lodging resistance.Slowing stem elongation and promoting vascular bundle formation and lignin synthesis could increase lodging resistance in late-sown rapeseed.展开更多
This study presents LA–ICP–MS U–Pb dating and whole-rock geochemical analyses of the Late Triassic Gangshan harzburgite in the Qingyuan area,with the aim of elucidating its petrogenesis and further constraining the...This study presents LA–ICP–MS U–Pb dating and whole-rock geochemical analyses of the Late Triassic Gangshan harzburgite in the Qingyuan area,with the aim of elucidating its petrogenesis and further constraining the early Mesozoic tectonic evolution of the eastern segment of the northern margin of the North China Block(NCB).Zircons from the harzburgites exhibit typical oscillatory growth zoning or striped absorp-tion in cathodoluminescence images.U–Pb analyses of zircons yield ages ranging from 2525 Ma to 225 Ma,with two youngest ages(225±7 Ma)indicating that the harzburgites were formed during Late Triassic.Geochemical analyses of the Gangshan harzburgites show that the rocks have low concentrations of SiO_(2)(42.38%–42.85%)and Al_(2)O_(3)(3.31%–3.33%),along with high concentrations of MgO(41.32%–41.76%),Cr(4856×10^(-6)–5191×10^(-6))and Ni(1942×10^(-6)–2041×10^(-6)).They also display low REE abundances(∑REE=4.38×10^(-6)–4.69×10^(-6))and flat REE patterns with low(La/Yb)_(N) ratios(1.24–1.56)and slightly po-sitive Eu anomalies(δEu=1.13–1.16).These features suggest that the Gangshan harzburgites are cumulates of basaltic magma derived from the depleted lithospheric mantle.Combined with previous studies,these Late Triassic mafic–ultramafic rocks,together with coeval granitoids in adjacent regions,constitute a typical bimodal association,suggesting that they formed in a post-orogenic extensional environment after the final closure of the Paleo-Asian Ocean.展开更多
The origins of peloidal micrites in reefal limestone are not yet well understood.Moscovian microbial reefs with abundant peloidal micrites from Guizhou,South China,provide an opportunity to study the peloids and their...The origins of peloidal micrites in reefal limestone are not yet well understood.Moscovian microbial reefs with abundant peloidal micrites from Guizhou,South China,provide an opportunity to study the peloids and their geological significance for this time interval.Three types of peloids are differentiated:microbial,lithic,and bioclastic peloids.Microbial peloids that are well-sorted and may form in situ by microbial activities.The poorly sorted lithic peloids are derived from erosion and redeposition of the micrite matrix caused by the bottom turbulence induced by periodic storms.Bioclastic peloids are completely micritized fragments of hard parts and shells.Microbial boring and encrustations promote the processes of micritization.Microbial peloids commonly develop in zones with low or normal energy levels,and contribute to the construction and stabilization of the framework.In contrast,the occurrence of lithic peloids reflects that the reefs are destroyed by bottom turbulence during growth.It is suggested that the microbial reefs were deposited under a dynamic balance between constructional versus destructive processes.By comparative analysis,the peloids as microbial in origin play a key role in the growth and stabilization of bioconstructions during Carboniferous,which should be paid more attention in the studies of Carboniferous buildups.展开更多
High-Mg andesite/diorite(HMA)is useful for identifying subduction-related processes in orogenic belts,including the identification of ophiolites formed in suprasubduction zone(SSZ)environments.The E'rentaolegai hi...High-Mg andesite/diorite(HMA)is useful for identifying subduction-related processes in orogenic belts,including the identification of ophiolites formed in suprasubduction zone(SSZ)environments.The E'rentaolegai high-Mg diorite from the Diyanmiao ophiolite in central Inner Mongolia,North China,has been investigated revealing low-K tholeiitic-calc-alkaline characteristics and have SiO_(2)contents of 53.44-54.92 wt%,MgO contents of 8.44-9.54 wt%,and Mg~#of 54.35-57.60,with variable Fe_(2)O_(3)(7.51-8.61 wt%),Al_(2)O_(3)(11.95-15.09 wt%),and Na_(2)O(3.42-3.94 wt%)contents,low K_(2)O(0.34-0.97 wt%),TiO_(2)(0.35-0.67 wt%),and P2O5(0.12-0.15 wt%)contents,and high Ni(43-193 ppm)and Cr(189-556 ppm)contents.Samples collected have low total rare earth element(REE)contents(30.58-77.80 ppm),with flat or slightly right-dipping REE patterns(La_(N)/Yb_(N)=2.19-3.11)and a lack of pronounced Eu anomalies.The samples are also enriched in large-ion lithophile elements(LILEs,e.g.,K,Rb,Ba,U,and Sr)and depleted in high field strength elements(e.g.,Ta,Nb,Ti,and P).The E'rentaolegai high-Mg diorite has characteristics typical of HMA,and are similar to those of sanukites from the Setouchi Arc in SW Japan.They also display high positiveε_(Nd)(t)values(+6.32 to+7.80),comparable to the values of their host rocks.Petrogenetic analyses suggest that the E'rentaolegai HMA was probably formed by the interaction of partial melts and aqueous fluids from subducted sediments with mantle peridotite.Zircon U-Pb dating reveals that the high-Mg diorite crystallized at 313.6±2.4 Ma,i.e.,late Carboniferous.Combining our data with the temporal and spatial distribution of the Diyanmiao SSZ-type ophiolite,we propose that the eastern Paleo-Asian Ocean had not closed by the late Carboniferous,but intra-oceanic subduction was ongoing.A new model of the initiation of subduction in the eastern PAO during the late Paleozoic.展开更多
BACKGROUND In the treatment of rectal cancer,a temporary loop ileostomy(TLI)is created after low anterior resection to protect bowel function in the postoperative period.Dehydration and kidney failure are significant ...BACKGROUND In the treatment of rectal cancer,a temporary loop ileostomy(TLI)is created after low anterior resection to protect bowel function in the postoperative period.Dehydration and kidney failure are significant potential complications in loop ileostomies.Compared to late closure(3-6 months),early closure(10-14 days)of the TLI may facilitate faster patient recovery and shorter hospital stays.AIM To compare early and late closure of TLIs and demonstrate that early stoma closure can be performed without increasing morbidity.METHODS This study included patients who underwent TLI for rectal cancer,with data collected prospectively between June 2016 and October 2024 and analyzed retrospectively.Patients whose stomas were closed in the late period(3-6 months)between June 2016 and October 2022(group A)were compared with those who underwent early closure(10-14 days)between October 2022 and 2024(group B),with the primary outcome being complication rate and the secondary outcome being quality of life.RESULTS A total of 270 TLIs were created(70.9%).Of these,120(44.4%)were closed in the late period(group A),and 150(55.6%)were closed in the early period(group B).There was no statistically significant difference between group A and group B in terms of demographic and clinicopathological characteristics(P>0.05).Perioperative(anesthesia management,operative time,blood loss,surgical technique)and postoperative findings(anastomotic leak,infection)were similar between the two groups and were not statistically significant(P>0.05).There were no statistically significant differences in complication rates as the primary outcome between the two groups.Quality of life as a secondary outcome was significantly higher in the early closure group(P<0.05).CONCLUSION No statistically significant difference was found between early and late loop ileostomy closure in terms of perioperative and postoperative morbidity.Early closure accelerated patients’psychological and social recovery.展开更多
The late Carboniferous to early Permian period is renowned for extensive coal formation and frequent paleowildfires.Nonetheless,the nature and distribution of these wildfires varied significantly over time.In an effor...The late Carboniferous to early Permian period is renowned for extensive coal formation and frequent paleowildfires.Nonetheless,the nature and distribution of these wildfires varied significantly over time.In an effort to elucidate the patterns of paleowildfires during the late Paleozoic Ice Age and to probe into the controlling mechanisms of paleowildfires under icehouse conditions,a comprehensive analysis was performed on coal samples from the Taiyuan and Shanxi formations within the Dacheng coalfield of Hebei Province,North China.The dataset was augmented with global inertinite data from the late Carboniferous to early Permian periods and was compared to paleowildfire patterns from the Pliocene to Holocene epochs.The results show that paleowildfires in the Dacheng coalfield of North China transitioned from moderate-scale,low-intensity surface fires to large-scale,relatively high-intensity ground fires.Globally,the distribution of paleowildfires shifted from Euramerica to Gondwana,Cathaysia,and Angara from 300 Ma to 290 Ma,accompanied by a corresponding increase in inertinite content.This spatial and temporal variation in wildfire activity appears to have been strongly influenced by paleoclimate and atmospheric conditions.At 300 Ma,cooler and wetter paleoclimate,coupled with relatively low atmospheric pO_(2) levels,likely contributed to a reduced incidence of paleowildfires.In contrast,at 290 Ma,warmer paleoclimate,higher atmospheric pO_(2) levels,and the flourishing mires in Gondwana,Cathaysia,and Angara were conducive to more intense paleowildfires.This pattern is further supported by the comparison to more recent icehouse periods.Similar to the late Carboniferous–early Permian period,wildfire activity increased from the Pliocene to the Holocene,highlighting the critical role of climatic conditions in driving wildfire proliferation under icehouse conditions.However,the Pleistocene to Holocene wildfires were less intense than those of the late Carboniferous–early Permian,suggesting that atmospheric oxygen concentrations played a key role in modulating the evolution of the fire systems over geological timescales.These findings underscore the complex interplay between climate,atmospheric composition,and vegetation in shaping wildfire dynamics across Earth’s history.展开更多
High-resolution,continuous Late Holocene lacustrine records are scarce in the Qaidam Basin,but is of especially important for our understanding the future climate variability in the western China.Here,we use grain siz...High-resolution,continuous Late Holocene lacustrine records are scarce in the Qaidam Basin,but is of especially important for our understanding the future climate variability in the western China.Here,we use grain size,element content and XRD-identified data from the Lake Hurleg in the eastern Qaidam Basin to present the Late Holocene climate variability,which have been temporally constrained using 210Pb-,137Cs-and AMS 14C dating.Our records demonstrate that decreased precipitation climate occurred at~800–1000 yr and~1300–1800 yr intervals,and increased precipitation occurred at~354–800 yr,~1000–1300 yr and~1800 yr to the present.The results show that the Qaidam Basin has undergone a process of warming and humidification since the Industrial Revolution,which is consistent with the meteorological records.The climate in the northeastern Qaidam Basin is dominated by the Asian Monsoon.展开更多
文摘Sporadic or late-onset Alzheimer’s disease(LOAD)occurs in 1 of 10 people over 65 years of age and comprises 95%of all AD patients.Unlike early-onset AD,which is caused by defined single gene mutations,the mechanisms and events underlying risk for LOAD are not fully understood and no substantial disease-modifying interventions are currently available.Age is the most prominent risk factor for LOAD,and interacting age-related and LOAD-associated factors contribute to its pathogenesis.Among these factors are changes in bioenergetic cell functions,which metabolize substrates and produce energy stored in adenosine triphosphate.
基金supported by the STI2030-Major Projects(2021ZD0202100,2021ZD0200801,and 2021ZD0201900)the National Natural Science Foundation of China(82130040,82288101).
文摘Dear Editor,Sleep deprivation and loss can have detrimental effects on brain function.Among common patterns of sleep loss are delayed sleep onset(early night sleep loss,EL)and premature awakening(late night sleep loss,LL).Here,we investigated the distinct impacts of EL and LL on resting-state brain activity.A total of 100 healthy students from several universities in Beijing were recruited and randomly assigned to one of three groups:EL,LL,or full sleep(FS).Restingstate functional magnetic resonance imaging(rs-fMRI)scans were conducted following the sleep manipulations.Compared to the FS group,the LL group showed abnormal low-frequency fluctuation(fALFF)in the prefrontal cortex and insula.
基金supported by the National Natural Science Foundation of China(42172010,42372071,41102037)。
文摘The Longshan orogenic belt is located in the southwestern margin of Ordos Basin at the junction zone between the Western Qinling and Northern Qilian orogenic belt.Voluminous Early Paleozoic magmatism in this area is of key significance for determining the Early Paleozoic tectonic evolution and deep crust-mantle structure.Previous studies mainly focused on the Paleozoic granites;the coeval mafic rocks in this area are still poorly understood.A set of Late Silurian intraplate tholeiitic basalts has been discovered in Longshan area,providing key evidence for the mantle source and deep geodynamic background in this area.The Late Silurian Angou basalt has similar geochemical features as intraplate tholeiitic basalt,with high Na_(2)O/K_(2)O ratios(5.22-8.25),enriched in large ion lithophile elements and LREE.In combination with their relatively evolved Sr-Nd isotopic composition[^(87)Sr/^(86)Sr(i)=0.7128-0.7140;ε_(Nd)(t)=-5.55 to-3.40],it is suggested that it originated from decompression melting of metasomatized enriched mantle in extensional setting.These results indicate that the mantle source in the junction zone of the West Qinling-North Qilian orogenic belt evolved from depleted to enriched with the continuation of Proto-Tethys subduction from the Cambrian to the Silurian.These results are of great significance to understanding the genesis of contemporaneous granite and the crust-mantle interaction in the junction zone between the Western Qinling and Northern Qilian orogenic belt.
基金supported by the National Natural Science Foundation of China(No.42372256)the Basic Science Center for Tibetan Plateau Earth System(No.41988101)the Second Tibetan Plateau Scientific Expedition and Research Program(No.2019QZKK0708)。
文摘The Zongwulong Shan-Qinghai Nanshan tectonic belt of the northern Xizang Plateau experienced a protracted tectonica history,including the openings and closures of the Proto-and Paleo-Tethyan Oceans.Although the tectonic belt has been extensively studied,details regarding the tectonic processes involved in its development remain controversial.To better constrain the tectonic processes of this tectonic belt,we conducted detailed field geological mapping,zircon U-Pb geochronology,and whole-rock geochemical and Sr-Nd isotopic analyses.Our results show that intrusive rocks in the tectonic belt crystallized in ca.292-233 Ma,perhaps in an arc/subduction setting.Geochemical and Sr-Nd isotopic data suggest that Early Permian-Late Triassic ultramaficintermediate intrusions were sourced from the enriched mantle,whereas intermediate-acidic rocks were sourced from mixed crust-mantle.We present the tectonic model that involves:(1)Early Devonian-Early Permian intracontinental extension occurred in the northern margin of the Qaidam continent(ca.416-292 Ma);(2)Early Permian-Late Triassic northward subduction of the Paleo-Tethyan Ocean resulted in arc magmatism(ca.292-233 Ma);and(3)subsequent Late Triassic intracontinental extension(ca.233-215 Ma).Our results suggest that the Late Paleozoic-Early Mesozoic development of the Zongwulong Shan-Qinghai Nanshan was related to the opening,subduction,and slab retreat of the Paleo-Tethyan Ocean,which has key implications for the tectonic evolution of the northern Tibetan Plateau.
基金financially supported by the National Natural Science Foundation of China(Grant No.42303073).
文摘The Late Cretaceous Jiepailing granitoids,located at the central Nanling Range in South China,are closely associated with significant Sn-Li-Be-F polymetallic metallogeny.The Jiepailing granitoids mainly consist of granitic porphyry and zinnwaldite granite.The two granitoids have an A-type affinity,showing elevated Rb/Sr ratios and significant depletions in Ba,Sr and P.Integrated zircon and monazite U-Pb dating results suggest that granitic porphyry and zinnwaldite granite were emplaced at~89 Ma and~94 Ma,respectively.The low Ce^(4+)/Ce^(3+)ratios of the Jiepailing granitoids,together with significant negative Eu anomalies of the zircons,indicate that their formation occurred under conditions of reduced oxygen fugacity.Through the analysis of zircon Hf-O and whole-rock Nd isotopes,it has been determined that both stages of the Jiepailing granitoids originated in the lower-middle Mesoproterozoic crustal basement[ε_(Nd)(t)=−5.33 to−4.96,t^(C)_(DM)(Nd)=1289-1234 Ma,ε_(Hf)(t)=−4.13 to+2.22,t^(C)_(DM)(Hf)=1418-1015 Ma andδ^(18)O_(Zrc)=6.33‰-7.72‰],with the involvement of mantle-derived materials.Both granitic porphyry and zinnwaldite granite exhibit elevated concentrations of fluorine(F),with the positive correlation between F and Sn emphasizing the crucial role of high F sources in tin mineralization.Drawing upon the study of the Late Cretaceous magma systems in southern Hunan and through comparison with the mineralized granites observed in coastal regions during the Late Cretaceous,a genetic model for the mineralized granites in the Nanling region is developed.When the Paleo-Pacific Plate retreated to the coastal region,the continental crust in southern China underwent extensional thinning and asthenospheric upwelling due to gravitational collapse.Such processes resulted in the partial melting of the middle-lower crustal metamorphic sedimentary basement and the subsequent formation of F-rich granitic magmas,related to tin mineralization.
文摘Excellent progress has been made in the last few decades in the cure rates of pediatric malignancies,with more than 80%of children with cancer who have access to contemporary treatment being cured.However,the therapies responsible for this survival can also produce adverse physical and psychological long-term outcomes,referred to as late effects,which appear months to years after the completion of cancer treatment.Research has shown that 60%to 90%of childhood cancer survivors(CCSs)develop one or more chronic health conditions,and 20%to 80%of survivors experience severe or life-threatening complications during adulthood.Therefore,understanding the late side effects of such treatments is important to improve the health and quality of life of the growing population of CCSs.
文摘A relatively well-preserved rodent fossil,including its incisors,cheek teeth,and postcranial skeleton,was collected from the Baiyin Obo in Siziwang Banner,Nei Mongol.A multifaceted research approach was undertaken in this study to conduct a comprehensive analysis on the newly discovered specimen.Based on a morphological comparison,the new specimen was identified as Hulgana cf.H.ertnia within the Ischyromyidae family.Incisive enamel microstructure analysis revealed the typical pauciserial enamel structure of Hulgana.Bone histological analysis indicates that the specimen represents a juvenile individual,which is consistent with the ontogenetic stage indicated by dental developmental stage and wear pattern.The application of geometric morphometrics to the calcaneus and bone histology of the femur and phalanx further substantiates the taxonomic classification of Hulgana as a terrestrial and cursorial rodent,exhibiting a degree of fossorial ability.This classification is analogous to that of certain extant cricetids and ground squirrels.
基金funded by the National Natural Science Foundation of China(Nos.42222209 and 42488201)the State Scholarship Fund.
文摘The Ordovician-Silurian transition was marked by extensive volcanic activity globally.In South China,intensive volcanism was documented by abundant ash layers in strata,but the origins and tectonic settings of these ashes remain controversial.This study presents the stratigraphic distribution of volcanic ash layers,zircon trace element and Hf isotope data from the Wanhe Section in the southwestern Yangtze Shelf,providing insights into the tectonic setting and the origin of the parent magmas.The results suggest that volcanic ashes in the southwestern Yangtze Shelf primarily originated from arc magmatism in the Wuyi-Yunkai Orogen,with a mixed source from mantle and crust.The findings corroborate the hypothesis that the Late Ordovician–Silurian Wuyi-Yunkai Orogen in South China represents a collisional orogenic belt.
基金financially supported by the National Key Research and Development Program of China(2024YFD2300303).
文摘In the rice–rapeseed cropping system in the Yangtze River Basin,late rapeseed sowing increases lodging.To identify the mechanisms of reduced lodging resistance,a two-year field experiment compared four rapeseed cultivars with differing lodging resistances under normal and late sowing.Rapid stem elongation during bolting in late-sown rapeseed reduced stem plumpness,vascular bundle development,and lignin accumulation,weakening lodging resistance.Slowing stem elongation and promoting vascular bundle formation and lignin synthesis could increase lodging resistance in late-sown rapeseed.
基金Supported by projects of the National Natural Science Foundation of China(Nos.42372063,41722204).
文摘This study presents LA–ICP–MS U–Pb dating and whole-rock geochemical analyses of the Late Triassic Gangshan harzburgite in the Qingyuan area,with the aim of elucidating its petrogenesis and further constraining the early Mesozoic tectonic evolution of the eastern segment of the northern margin of the North China Block(NCB).Zircons from the harzburgites exhibit typical oscillatory growth zoning or striped absorp-tion in cathodoluminescence images.U–Pb analyses of zircons yield ages ranging from 2525 Ma to 225 Ma,with two youngest ages(225±7 Ma)indicating that the harzburgites were formed during Late Triassic.Geochemical analyses of the Gangshan harzburgites show that the rocks have low concentrations of SiO_(2)(42.38%–42.85%)and Al_(2)O_(3)(3.31%–3.33%),along with high concentrations of MgO(41.32%–41.76%),Cr(4856×10^(-6)–5191×10^(-6))and Ni(1942×10^(-6)–2041×10^(-6)).They also display low REE abundances(∑REE=4.38×10^(-6)–4.69×10^(-6))and flat REE patterns with low(La/Yb)_(N) ratios(1.24–1.56)and slightly po-sitive Eu anomalies(δEu=1.13–1.16).These features suggest that the Gangshan harzburgites are cumulates of basaltic magma derived from the depleted lithospheric mantle.Combined with previous studies,these Late Triassic mafic–ultramafic rocks,together with coeval granitoids in adjacent regions,constitute a typical bimodal association,suggesting that they formed in a post-orogenic extensional environment after the final closure of the Paleo-Asian Ocean.
基金supported by the National Natural Science Foundation of China(Grant Nos.42272008 and 41972002).
文摘The origins of peloidal micrites in reefal limestone are not yet well understood.Moscovian microbial reefs with abundant peloidal micrites from Guizhou,South China,provide an opportunity to study the peloids and their geological significance for this time interval.Three types of peloids are differentiated:microbial,lithic,and bioclastic peloids.Microbial peloids that are well-sorted and may form in situ by microbial activities.The poorly sorted lithic peloids are derived from erosion and redeposition of the micrite matrix caused by the bottom turbulence induced by periodic storms.Bioclastic peloids are completely micritized fragments of hard parts and shells.Microbial boring and encrustations promote the processes of micritization.Microbial peloids commonly develop in zones with low or normal energy levels,and contribute to the construction and stabilization of the framework.In contrast,the occurrence of lithic peloids reflects that the reefs are destroyed by bottom turbulence during growth.It is suggested that the microbial reefs were deposited under a dynamic balance between constructional versus destructive processes.By comparative analysis,the peloids as microbial in origin play a key role in the growth and stabilization of bioconstructions during Carboniferous,which should be paid more attention in the studies of Carboniferous buildups.
基金supported by the Ministry of Science and Technology of the People’s Republic of China(Grant No.2022FY101704)the National Natural Science Foundation of China(Grant No.41972061)+1 种基金Science and Technology Innovation Team of Hebei GEO University(30801071)the China Geological Survey(Grant Nos.1212011120701 and 1212011120711)。
文摘High-Mg andesite/diorite(HMA)is useful for identifying subduction-related processes in orogenic belts,including the identification of ophiolites formed in suprasubduction zone(SSZ)environments.The E'rentaolegai high-Mg diorite from the Diyanmiao ophiolite in central Inner Mongolia,North China,has been investigated revealing low-K tholeiitic-calc-alkaline characteristics and have SiO_(2)contents of 53.44-54.92 wt%,MgO contents of 8.44-9.54 wt%,and Mg~#of 54.35-57.60,with variable Fe_(2)O_(3)(7.51-8.61 wt%),Al_(2)O_(3)(11.95-15.09 wt%),and Na_(2)O(3.42-3.94 wt%)contents,low K_(2)O(0.34-0.97 wt%),TiO_(2)(0.35-0.67 wt%),and P2O5(0.12-0.15 wt%)contents,and high Ni(43-193 ppm)and Cr(189-556 ppm)contents.Samples collected have low total rare earth element(REE)contents(30.58-77.80 ppm),with flat or slightly right-dipping REE patterns(La_(N)/Yb_(N)=2.19-3.11)and a lack of pronounced Eu anomalies.The samples are also enriched in large-ion lithophile elements(LILEs,e.g.,K,Rb,Ba,U,and Sr)and depleted in high field strength elements(e.g.,Ta,Nb,Ti,and P).The E'rentaolegai high-Mg diorite has characteristics typical of HMA,and are similar to those of sanukites from the Setouchi Arc in SW Japan.They also display high positiveε_(Nd)(t)values(+6.32 to+7.80),comparable to the values of their host rocks.Petrogenetic analyses suggest that the E'rentaolegai HMA was probably formed by the interaction of partial melts and aqueous fluids from subducted sediments with mantle peridotite.Zircon U-Pb dating reveals that the high-Mg diorite crystallized at 313.6±2.4 Ma,i.e.,late Carboniferous.Combining our data with the temporal and spatial distribution of the Diyanmiao SSZ-type ophiolite,we propose that the eastern Paleo-Asian Ocean had not closed by the late Carboniferous,but intra-oceanic subduction was ongoing.A new model of the initiation of subduction in the eastern PAO during the late Paleozoic.
文摘BACKGROUND In the treatment of rectal cancer,a temporary loop ileostomy(TLI)is created after low anterior resection to protect bowel function in the postoperative period.Dehydration and kidney failure are significant potential complications in loop ileostomies.Compared to late closure(3-6 months),early closure(10-14 days)of the TLI may facilitate faster patient recovery and shorter hospital stays.AIM To compare early and late closure of TLIs and demonstrate that early stoma closure can be performed without increasing morbidity.METHODS This study included patients who underwent TLI for rectal cancer,with data collected prospectively between June 2016 and October 2024 and analyzed retrospectively.Patients whose stomas were closed in the late period(3-6 months)between June 2016 and October 2022(group A)were compared with those who underwent early closure(10-14 days)between October 2022 and 2024(group B),with the primary outcome being complication rate and the secondary outcome being quality of life.RESULTS A total of 270 TLIs were created(70.9%).Of these,120(44.4%)were closed in the late period(group A),and 150(55.6%)were closed in the early period(group B).There was no statistically significant difference between group A and group B in terms of demographic and clinicopathological characteristics(P>0.05).Perioperative(anesthesia management,operative time,blood loss,surgical technique)and postoperative findings(anastomotic leak,infection)were similar between the two groups and were not statistically significant(P>0.05).There were no statistically significant differences in complication rates as the primary outcome between the two groups.Quality of life as a secondary outcome was significantly higher in the early closure group(P<0.05).CONCLUSION No statistically significant difference was found between early and late loop ileostomy closure in terms of perioperative and postoperative morbidity.Early closure accelerated patients’psychological and social recovery.
基金supported by the National Natural Science Foundation of China(Grant No.42302205 and No.42002128)the Fundamental Research Funding Project of Liaoning Education Department(Grant No.LJKMZ20220692)the Open Fund of State Key Laboratory of Coal Resources and Safe Mining(Grant No.SKLCRSM22KFA07 and No.SKLCRSM20KFA02).
文摘The late Carboniferous to early Permian period is renowned for extensive coal formation and frequent paleowildfires.Nonetheless,the nature and distribution of these wildfires varied significantly over time.In an effort to elucidate the patterns of paleowildfires during the late Paleozoic Ice Age and to probe into the controlling mechanisms of paleowildfires under icehouse conditions,a comprehensive analysis was performed on coal samples from the Taiyuan and Shanxi formations within the Dacheng coalfield of Hebei Province,North China.The dataset was augmented with global inertinite data from the late Carboniferous to early Permian periods and was compared to paleowildfire patterns from the Pliocene to Holocene epochs.The results show that paleowildfires in the Dacheng coalfield of North China transitioned from moderate-scale,low-intensity surface fires to large-scale,relatively high-intensity ground fires.Globally,the distribution of paleowildfires shifted from Euramerica to Gondwana,Cathaysia,and Angara from 300 Ma to 290 Ma,accompanied by a corresponding increase in inertinite content.This spatial and temporal variation in wildfire activity appears to have been strongly influenced by paleoclimate and atmospheric conditions.At 300 Ma,cooler and wetter paleoclimate,coupled with relatively low atmospheric pO_(2) levels,likely contributed to a reduced incidence of paleowildfires.In contrast,at 290 Ma,warmer paleoclimate,higher atmospheric pO_(2) levels,and the flourishing mires in Gondwana,Cathaysia,and Angara were conducive to more intense paleowildfires.This pattern is further supported by the comparison to more recent icehouse periods.Similar to the late Carboniferous–early Permian period,wildfire activity increased from the Pliocene to the Holocene,highlighting the critical role of climatic conditions in driving wildfire proliferation under icehouse conditions.However,the Pleistocene to Holocene wildfires were less intense than those of the late Carboniferous–early Permian,suggesting that atmospheric oxygen concentrations played a key role in modulating the evolution of the fire systems over geological timescales.These findings underscore the complex interplay between climate,atmospheric composition,and vegetation in shaping wildfire dynamics across Earth’s history.
基金supported by the National Natural Science Foundation of China(No.41401059)Science and Technology Plan Project of Qinghai Province(2022-ZJ-732)West Light Foundation of Chinese Academy of Sciences(No.Y510091019)。
文摘High-resolution,continuous Late Holocene lacustrine records are scarce in the Qaidam Basin,but is of especially important for our understanding the future climate variability in the western China.Here,we use grain size,element content and XRD-identified data from the Lake Hurleg in the eastern Qaidam Basin to present the Late Holocene climate variability,which have been temporally constrained using 210Pb-,137Cs-and AMS 14C dating.Our records demonstrate that decreased precipitation climate occurred at~800–1000 yr and~1300–1800 yr intervals,and increased precipitation occurred at~354–800 yr,~1000–1300 yr and~1800 yr to the present.The results show that the Qaidam Basin has undergone a process of warming and humidification since the Industrial Revolution,which is consistent with the meteorological records.The climate in the northeastern Qaidam Basin is dominated by the Asian Monsoon.
