Objective: to analyze the clinical efficacy of etacridine combined with mifepristone (MFP) in the treatment of induced labor during middle pregnancy. Methods: from May 2015 to April 2020, 50 patients with midterm preg...Objective: to analyze the clinical efficacy of etacridine combined with mifepristone (MFP) in the treatment of induced labor during middle pregnancy. Methods: from May 2015 to April 2020, 50 patients with midterm pregnancy during labor induction period in our hospital were selected. The digital table was randomly divided into two groups with 25 cases in each group. Treatment was given to patients from a single drug group. The etazidine-bound group was treated with etazidine, acridine combined with MFP. The time, success rate, and incidence of complications were compared between the two groups from the start of dosing to embryo excretion. Results: the duration from initial administration to embryo expulsion in combination group was 36.21±2.45h shorter than that in single drug group, 56.13±5.01h, P < 0.05. The combined power was 100.00% higher than that of the single drug group (76.00%, P < 0.05). There were no serious complications in the two groups, including 2 cases of low fever in the monotherapy group and 3 cases of mild diarrhea and nausea in the combination group (P > 0.05). Conclusion: the clinical effect of ethacridine combined with MFP in the treatment of induced labor in the second trimester is better than ethacridine, which can improve the success rate and shorten the time of induced labor, with high safety.展开更多
A laboratory experiment was conducted inside a wind wave tank to investigate the wave induced turbulence. In this experiment, the wave surface elevation and velocity beneath the water surface were measured simultaneou...A laboratory experiment was conducted inside a wind wave tank to investigate the wave induced turbulence. In this experiment, the wave surface elevation and velocity beneath the water surface were measured simultaneously to investigate the relation between the wave status and wave induced turbulence. The profile of the turbulent dissipation rate and Reynolds stress were calculated using experimental data. The effect of the wave status on turbulence is investigated with regard to the wind wave, swell, and mixed wave conditions. It was depicted that the turbulence decreased with increasing depth from the water surface and that the turbulence that was induced by a wave with larger wavelength and wave height is much stronger for the same wave status. Finally, we observed that the wind wave is more effective in activating the wave induced turbulence.展开更多
Background: Induction of labor is the stimulation of the uterus to initiate the labor process whether by administering oxytocin, prostaglandin or reputing the membrane [1]. It was realized that the number of induction...Background: Induction of labor is the stimulation of the uterus to initiate the labor process whether by administering oxytocin, prostaglandin or reputing the membrane [1]. It was realized that the number of induction of labor patients was thought to be increasing in comparison with the spontaneous labor patients. Therefore, the complications of induced labor were higher. A detailed analysis was needed to confirm that. Objective: The aim of the study is to analyze the outcomes between spontaneous versus induced labor. Materials and Methods: A retrospective analysis was conducted at our tertiary care university hospital, in the period from December 2015 to December 2016 when 311 women were divided into two groups: group 1, women who had spontaneous labor (n = 106) compared with group 2, women who were labor induced (n = 205). Complications of pregnancy, delivery type, tear, episiotomy, blood transfusion and instruments used were analyzed retrospectively. Results: The mean ± SD of baseline characteristics, like age, height, weight, BMI and hemoglobin level for all study samples was 28.59 ± 5.95 years, 1.58 ± 0.06 m, 71.77 ± 13.42 kg, 28.59 ± 5.89 kg/m2 and 11.08 ± 1.45 g/dl respectively. A statistically significant difference was noticed in the duration of labor between spontaneous and induced labor (95% CI: 9.194 - 152.130;p-value 0.004 and OR: 0.239). There was no significant difference in complications, delivery type (Spontaneous Vaginal Delivery (SVD) or other), blood transfusion, and instrument used between women who had spontaneous labor versus induced labor. However, significant differences in tear (95% CI: 4.354 - 0.996;p-value 0.035) and episiotomy (95% CI: 0.928 - 0.224;p-value 0.028) were found between the two groups. In conclusion, the induced labor was found to be associated with high incidence of duration of labor, tear and episiotomy. Patients should always be counseled when there it is an option between the two delivery types.展开更多
Misoprostol (Cytotec, Pfizer) is a prostaglandin E1 analogue widely used in labor induction. Understanding of potential risks of misoprostol in labor induction is lacking as the drug is used off-label in most countrie...Misoprostol (Cytotec, Pfizer) is a prostaglandin E1 analogue widely used in labor induction. Understanding of potential risks of misoprostol in labor induction is lacking as the drug is used off-label in most countries. A 35-year-old G3P2 woman with post-date pregnancy at 40 + 3 weeks was induced using titrated oral misoprostol. Following delivery, post-partum hemorrhage was noted and, upon discovery of a uterine wall rupture due to congenital weakness of the myometrium, emergency abdominal total hysterectomy was conducted. Following surgery, the patient made a full recovery and was discharged. The main contraindications for misoprostol in labor induction are a scarred uterus or multipara greater than 4. Uterine wall weakness should be considered as a potential contraindication. Extreme vigilance is required in use of misoprostol for labor induction.展开更多
The dynamic response of two flexible model risers in tandem arrangement immersed in a stepped current was analyzed. The risers, with an external diameter of 20 mm and a total length of 6200 mm, had an aspect ratio of ...The dynamic response of two flexible model risers in tandem arrangement immersed in a stepped current was analyzed. The risers, with an external diameter of 20 mm and a total length of 6200 mm, had an aspect ratio of 310. They were hinged to the support structure at the center-to-center distances away 3-12 times the external diameter. The top 1200 mm was exposed to a uniform current at a speed which was up to 0.9 m/s（the Reynolds number was 18000） and the rest in still water. The dynamic responses, which were obtained through the Fiber Bragg Grating strain gauges mounted on the surface, were analyzed by studying the cross-flow amplitudes and modal weights. The cross-flow vibration were observed up to the third mode, and the modal transformation from the second mode to the third mode was clearly observed. The experiment confirmed that the typical vortex-induced vibration（VIV） had occurred on the up-stream riser. But for the down-stream riser, the main excitation mechanism was wake-induced vibration（WIV）. The modal transformation of WIV was more complex than that of VIV, which might be helpful for other researchers to study the interference effect.展开更多
Determination of the chemical composition of cement and ratio values of clinker plays an important role in cement plants as part of the optimal process control and product quality evaluation. In the present paper, a l...Determination of the chemical composition of cement and ratio values of clinker plays an important role in cement plants as part of the optimal process control and product quality evaluation. In the present paper, a laboratory laser-induced breakdown spectroscopy （LIBS） apparatus mainly comprising a sealed optical module and an analysis chamber has been designed for possible application in cement plants for on-site quality analysis of cement. Emphasis is placed on the structure and operation of the LIBS apparatus, the sealed optical path, the temperature controlled spectrometer, the sample holder, the proper calibration model established for minimizing the matrix effects, and a correction method proposed for overcoming the ＇drift＇ obstacle. Good agreement has been found between the laboratory measurement results from the LIBS method and those from the traditional method. The absolute measurement errors presented here for oxides analysis are within 0.5%, while those of ratio values are in the range of 0.02 to 0.05. According to the obtained results, this laboratory LIBS apparatus is capable of performing reliable and accurate, composition and proximate analysis of cement and is suitable for application in cement plants.展开更多
Radiation-induced reduction of chromium（Ⅵ）（Cr（Ⅵ） by ,γ-irradiation was studied with an initial concentration of 42 mg/L in aqueous solutions. Several factors which might affect the reduction of Cr（Ⅵ） to Cr...Radiation-induced reduction of chromium（Ⅵ）（Cr（Ⅵ） by ,γ-irradiation was studied with an initial concentration of 42 mg/L in aqueous solutions. Several factors which might affect the reduction of Cr（Ⅵ） to Cr（Ⅲ） were examined, pH of aqueous solution affects the reduction efficiency significantly. Acidic condition of aqueous solution accelerates the process. At pH 2, a reduction of 86.2% was achieved with the absorbed dose of 15 kGy, while, with the same dose, at pH 5 and 7, the reduction ofCr （Ⅵ） were only 36.3% and 22.2%, respectively. Ethanol （0.1% in V：V） and sodium carbonate （1 mmol/L） were added into the solution respectively as relatively non-toxic hydroxyl radical scavengers. Reduction rate increased greatly in the presence of ethanol at each pH. Reduction efficiency of Cr（Ⅵ） was enhanced in neutral condition with the addition of sodium carbonate, however, no enhancement was found in acidic condition. The reduction of Cr（Ⅵ） was restrained when the solution was saturated with oxygen; however, the restraint was not significant.展开更多
In the context of the coordinated pursuit of"carbon peak and neutrality"objectives,alongside the strategy to establish a robust agricultural nation,the economic and social development of rural areas is under...In the context of the coordinated pursuit of"carbon peak and neutrality"objectives,alongside the strategy to establish a robust agricultural nation,the economic and social development of rural areas is undergoing a profound paradigm shift.The traditional rural division of labor pattern,which depends on tangible factors such as land,labor,and capital,has increasingly encountered developmental challenges characterized by diminishing marginal returns and a detrimental cycle of internal competition.The new quality productive force,centered on data,algorithms,green technologies,bioengineering,and clean energy,offers a potential pathway for the rural division of labor system to overcome the"low-level equilibrium".This force is characterized by attributes such as non-exclusivity,replicability,network collaboration,and ecological compatibility.This paper develops a three-dimensional collaborative analytical framework encompassing"technology,institution,and culture".It systematically elucidates the internal logic by which new quality productive forces drive the transformation of the rural division of labor from"quantitative factor matching"to"qualitative structural reorganization"through three principal mechanisms:technology embedding,institutional reconstruction,and cultural coupling.Furthermore,the study proposes corresponding policy recommendations,thereby offering theoretical insights to support the modernization of China s agriculture and rural areas,as well as the development of a strong agricultural country.展开更多
Diplodia tip blight,caused by Diplodia sapinea,is a global pine necrotic disease causing heavy economic losses to the pine industry.Chemical control,its main current management,easily induces pathogen resistance and e...Diplodia tip blight,caused by Diplodia sapinea,is a global pine necrotic disease causing heavy economic losses to the pine industry.Chemical control,its main current management,easily induces pathogen resistance and environmental pollution,which biological control avoids.This study investigated juniper essential oil’s efficacy against the disease on Mongolian Scots pine(Pinus sylvestris var.mongolica)and its induced resistance mechanisms via pot experiments,physiological assays(defense enzyme activities,resistant substances)and metabolomic sequencing(secondary metabolites).Results showed varied efficacy:three foliar sprays of 10μL mL^(-1) oil achieved the best control phenylalanine ammonia-lyase(PAL),polyphenol oxidase(82.9%).The 20μL mL^(-1) treatment significantly increased(PPO)activities,and contents of lignin,flavonoids and total phenolics.Metabolomic analysis showed 326 upregulated and 527 downregulated different metabolites in essential oilinduced and pathogen-inoculated pines,compared to 483 upregulated and 277 downregulated metabolites in noninduced but inoculated pines.The differentially expressed metabolites in treated pines were primarily enriched in pathways related to amino acid metabolism and plant secondary metabolite biosynthesis,with notably increased expression levels of ferulic acid,scopoletin,pipecolic acid,D-proline,and DL-arginine.Therefore,juniper essential oil protects against D.sapinea by inducing systemic acquired resistance in Mongolian Scots pine.In conclusion,juniper essential oil controls D.sapinea by inducing systemic acquired resistance(SAR)in Mongolian Scots pine,clarifying the molecular mechanism and supporting biological control of the disease.展开更多
While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model...While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model incorporating rate-and-state friction laws to investigate fault reactivation mechanisms during early-stage CO_(2)injection.The competing effects of pore pressure diffusion and fluid pressurization are systematically investigated,considering three key factors:permeability variations within fault damage zones,normal stress variation coefficients,and injection parameters.Numerical simulations reveal that slower CO_(2)migration causes limited pressure perturbation(<0.3 MPa over 15 d)compared to single-phase fluid injection.Fluid pressurization enhances fault strength and delays reactivation,though this stabilizing effect diminishes in low-permeability damage zones.Highly permeable damage zones promote larger rupture areas despite strengthening from pressurization,as reduced effective stress accelerates failure.Paradoxically,while fluid pressurization increases fault strength,it simultaneously elevates seismic risk through amplified stress drops during slip events.Temporal analysis shows that fluid pressurization dominates initial fault response,while sustained pore pressure diffusion ultimately drives reactivation.Increased normal stress variation coefficients and injection rates accelerate localized rupture initiation but restrict propagation due to non-critically stressed states.This discrepancy demonstrates that regions with positive Coulomb failure stress changes do not correlate well with actual slip zones.These findings highlight the critical interplay between transient pressurization effects and progressive pressure diffusion during early CO_(2)injection phases,providing crucial insights for seismic risk management in CO_(2)storage projects.展开更多
Accurate phenological information is essential for measuring ecosystem dynamics and carbon uptake.Southwest China is one of the country's largest terrestrial carbon sink regions and plays a crucial role in carbon ...Accurate phenological information is essential for measuring ecosystem dynamics and carbon uptake.Southwest China is one of the country's largest terrestrial carbon sink regions and plays a crucial role in carbon peaking and neutrality.However,its complex terrain,fragile ecosystem,and variable climate challenge carbon sink stability.Vegetation phenology significantly impacts carbon absorption and release,making accurate phenological data essential for understanding carbon sequestration dynamics.The widespread distribution of evergreen forests and their weak seasonal variation in canopy introduce significant uncertainties in extracting phenology using traditional remote sensing information in this region.These limitations can lead to inaccurate assessments of carbon sink dynamics.Therefore,precise phenology extraction and analysis are vital for improving ecosystem dynamics and the carbon cycle in Southwest China.Firstly,we employed different ways to evaluate the ability of solar-induced chlorophyll fluorescence(SIF)and traditional remote sensing information to extract phenology.Secondly,based on SIF,we analyzed the spatial and temporal changes in the start of the growing season(SOS),the end of the growing season(EOS),and the length of the growing season(LOS)from 2001 to 2020.Finally,we systematically analyzed the response of SOS and EOS to five preseason climatic factors.The results showed that(1)SIF outperformed traditional remote sensing information in extracting phenology.(2)Vegetation phenology exhibited significant spatial heterogeneity.Moreover,SOS,EOS,and LOS showed trends of advancement,delay,and extension both overall and across all vegetation types.(3)Precipitation was the main factor influencing SOS,while surface downward solar radiation and mean temperature were the main factors affecting EOS,and the phenology of different vegetation types showed a great difference in response to preseason climate factors.These findings improve our understanding of vegetation phenology and its dynamics over Southwest China.展开更多
CO_(2)utilization powered by sustainable energy offers a promising route to mitigate carbon emissions while producing value-added chemicals[1].Among these pathways,CO_(2)hydrogenation is especially attractive because ...CO_(2)utilization powered by sustainable energy offers a promising route to mitigate carbon emissions while producing value-added chemicals[1].Among these pathways,CO_(2)hydrogenation is especially attractive because it integrates renewable H 2 with carbon resources,which have achieved notable success in producing methanol,CO,etc.[2,3].展开更多
Microbially induced calcium carbonate precipitation(MICP)is an eco-friendly technology for soil improvement.Although numerous experiments have been conducted to solidify sand foundations using MICP,the mechanisms by w...Microbially induced calcium carbonate precipitation(MICP)is an eco-friendly technology for soil improvement.Although numerous experiments have been conducted to solidify sand foundations using MICP,the mechanisms by which grain interfacial morphologies influencethe MICP process remain unclear.This study utilized 3D-printed flowcells with different boundary morphologies to investigate the effects of interfacial morphologies on the MICP process.CaCO_(3)precipitation characteristics were investigated through microscopic observation and image quantificationanalysis.The results indicate that low flowvelocities near the interface promote bacterial accumulation due to reduced hydrodynamic shear forces.Rough interfaces,compared to smooth ones,enhance bacterial adsorption owing to the larger regions of low flowvelocity,increased surface area,and the formation of local eddies,which promote greater CaCO_(3)precipitation.Compared to the regions away from the interface,a higher abundance of small CaCO_(3)crystals is observed near the interface because of the high urease activity from bacteria and the reduced shear-induced entrainment due to the low flowvelocity.Besides,larger crystals also preferentially precipitate in proximity to interfaces as the low flowvelocity enhances crystal growth according to the particle attachment theory.The presence of rough interfaces further reduces flowvelocities,leading to the precipitation of larger and more densely packed CaCO_(3)crystals.Therefore,rough interfaces promote the microbially induced calcium carbonate precipitation.This work is expected to enhance the understanding of microbially induced calcium carbonate precipitation characteristics on solid surfaces such as soil grains and contribute to the optimization of MICP applications.展开更多
Previous research has demonstrated the feasibility of repairing nerve defects through acellular allogeneic nerve grafting with bone marrow mesenchymal stem cells.However,adult tissue–derived mesenchymal stem cells en...Previous research has demonstrated the feasibility of repairing nerve defects through acellular allogeneic nerve grafting with bone marrow mesenchymal stem cells.However,adult tissue–derived mesenchymal stem cells encounter various obstacles,including limited tissue sources,invasive acquisition methods,cellular heterogeneity,purification challenges,cellular senescence,and diminished pluripotency and proliferation over successive passages.In this study,we used induced pluripotent stem cell-derived mesenchymal stem cells,known for their self-renewal capacity,multilineage differentiation potential,and immunomodulatory characteristics.We used induced pluripotent stem cell-derived mesenchymal stem cells in conjunction with acellular nerve allografts to address a 10 mm-long defect in a rat model of sciatic nerve injury.Our findings reveal that induced pluripotent stem cell-derived mesenchymal stem cells exhibit survival for up to 17 days in a rat model of peripheral nerve injury with acellular nerve allograft transplantation.Furthermore,the combination of acellular nerve allograft and induced pluripotent stem cell-derived mesenchymal stem cells significantly accelerates the regeneration of injured axons and improves behavioral function recovery in rats.Additionally,our in vivo and in vitro experiments indicate that induced pluripotent stem cell-derived mesenchymal stem cells play a pivotal role in promoting neovascularization.Collectively,our results suggest the potential of acellular nerve allografts with induced pluripotent stem cell-derived mesenchymal stem cells to augment nerve regeneration in rats,offering promising therapeutic strategies for clinical translation.展开更多
Concerns about the long-term safety and efficacy of glibenclamide(GLIB),a type 2 diabetes mellitus(T2DM)treatment,have been reported[1].Recent evidence indicates the gut microbiota composition significantly affects ho...Concerns about the long-term safety and efficacy of glibenclamide(GLIB),a type 2 diabetes mellitus(T2DM)treatment,have been reported[1].Recent evidence indicates the gut microbiota composition significantly affects host glucose metabolism and drugbioavailability,increasingthe efficacy of T2DM therapy[2].In this context,probiotic-drug coadministration,an emerging adjunct approach for treating metabolic diseases,improves therapeutic outcomes and ameliorates side effects[3].展开更多
In recent years,the obstetrics department has advocated vaginal delivery to reduce the rate of cesarean sections.However,in clinical practice,pregnant women are prone to anxiety before childbirth,making it difficult t...In recent years,the obstetrics department has advocated vaginal delivery to reduce the rate of cesarean sections.However,in clinical practice,pregnant women are prone to anxiety before childbirth,making it difficult to perform a vaginal trial delivery smoothly.The combined approach of ADIET communication and delivery rehearsal for vaginal trial delivery can provide a reference for reducing prenatal anxiety,shortening labor duration,facilitating a smooth delivery,and ensuring the safety of both mothers and babies.AIM To analyze the effect of AIDET communication combined with labor rehearsal on vaginal trial delivery.METHODS A study conducted between January 2023 and December 2023 included 200 vaginal trials.Women were randomly assigned to an observation group(100 women),which received ADIET communication plus delivery intervention,and a control group(100 women),which received routine communication plus delivery intervention.This study aimed to compare antenatal anxiety status as measured using the Maternal Anxiety Scale,labor duration,delivery efficacy as assessed using the simplified Chinese version of the Childbirth Self-Efficacy Inventory,and delivery outcomes.RESULTS After the intervention,the observation group had a lower Maternal Anxiety Scale score and higher Childbirth Self-Efficacy Inventory score(P<0.05)than the control group(P<0.05),whereas the observation group had higher natural delivery,cesarean delivery,vaginal delivery,and neonatal asphyxia rates(P<0.05).CONCLUSION For women undergoing vaginal trial delivery,a combination of AIDET communication and delivery rehearsal can relieve prenatal anxiety,enhance delivery efficiency,shorten labor duration,and somewhat improve delivery outcomes.展开更多
In the era of digital capitalism with the explosion of data and information,human society will be greatly affected by digital capital,and all walks of life will be included in the chain of information-based labor prod...In the era of digital capitalism with the explosion of data and information,human society will be greatly affected by digital capital,and all walks of life will be included in the chain of information-based labor production,giving rise to a new type of labor form called“digital labor”.This paper discusses the alienation of digital labor in the context of digital capitalism,take Marx’s theory of alienated labor as the perspective,and analyze the fourfold alienation of digital labor in terms of producing products,labor process,self-realization of laborers,and social relations by combing the historical development of digital labor.Based on the above analysis,the article proposes the logical and practical paths to crack the alienation of digital labor:improve media literacy and thinking discernment,make full use of the positive effects of digital technology,and strengthen the governance of digital platforms,in order to build a fairer and more shared digital labor environment,and to realize the self-emancipation of laborers and the healthy development of the digital economy.展开更多
Labor provisions have become a fundamental trade rule in regional and bilateral trade agreements.Although China’s legislation on pilot Free Trade Zones includes content related to labor protection,it primarily aligns...Labor provisions have become a fundamental trade rule in regional and bilateral trade agreements.Although China’s legislation on pilot Free Trade Zones includes content related to labor protection,it primarily aligns with labor indicators in“Doing Business”,the assessment of business situations issued by the World Bank.It differs from the labor rights protection focus emphasized in trade agreements.The latest strategic documents issued by the State Council of China have addressed this issue to fully achieve the goal of aligning Free Trade Zones with high-standard trade agreements.Building on the development of Free Trade Zone legislation and domestic labor law governance,China should proactively explore a tailored approach to labor provisions in Free Trade Agreements.In this approach,it should explicitly define the“baseline”and“ceiling”for labor provisions during negotiations and,within this framework,establish benchmarks for labor rights protection,enforcement mechanisms,and cross-border regulatory mechanisms suited to the specific conditions of the agreement parties.展开更多
BACKGROUND The discovery of induced pluripotent stem cells revolutionized regenerative medicine,providing a source for generating induced pluripotent stem cell-derived mesenchymal stem cells(iMSCs).AIM To evaluate and...BACKGROUND The discovery of induced pluripotent stem cells revolutionized regenerative medicine,providing a source for generating induced pluripotent stem cell-derived mesenchymal stem cells(iMSCs).AIM To evaluate and compare five iMSC differentiation protocols,assessing their efficiency,phenotypic characteristics,and functional properties relative to primary mesenchymal stem cells(MSCs).METHODS Five iMSC differentiation protocols were assessed:SB431542-based differentiation(iMSC1,iMSC3),an iMatrix-free method(iMSC2),growth factor supplementation(iMSC4),and embryoid body formation with retinoic acid(EB-iMSC).iMSC identity was confirmed according to the International Society for Cell&Gene Therapy 2006 criteria,requiring expression of surface markers(CD105,CD73,CD90)and absence of pluripotency markers.Functional assays were conducted to evaluate differentiation potential(osteogenic and adipogenic),proliferation,mitochondrial function,reactive oxygen species,senescence,and migration.RESULTS All iMSC types expressed MSC markers and lacked pluripotency markers.EBiMSC and iMSC2 showed enhanced osteogenesis(runt-related transcription factor 2;P≤0.01 and P≤0.0001,respectively),while adipogenic potential was reduced in iMSC2(Adipsin;P≤0.01)and EB-iMSC(Adipsin and peroxisome proliferatoractivated receptor gamma;P≤0.0001 and P≤0.01,respectively).Proliferation was comparable or superior to bone marrow MSCs,except in iMSC1,with iMSC4 showing the highest rate(MTT assay;P values ranged from 0.01 to 0.001).Despite reduced mitochondrial health in iMSC3 and iMSC4(P≤0.001),reactive oxygen species levels were lower in all iMSCs(P values ranged from 0.001 to 0.0001),and senescence was significantly reduced in all iMSCs with the exception of iMSC1(P values ranged from 0.01 to 0.0001).Migration was most reduced in iMSC4(P≤0.001 at 24 hours and P≤0.0001 at 48 hours).CONCLUSION While all protocols generated functional iMSCs,variations in differentiation,proliferation,and function emphasize the impact of protocol selection.These findings contribute to optimizing iMSC generation for research and clinical applications.展开更多
文摘Objective: to analyze the clinical efficacy of etacridine combined with mifepristone (MFP) in the treatment of induced labor during middle pregnancy. Methods: from May 2015 to April 2020, 50 patients with midterm pregnancy during labor induction period in our hospital were selected. The digital table was randomly divided into two groups with 25 cases in each group. Treatment was given to patients from a single drug group. The etazidine-bound group was treated with etazidine, acridine combined with MFP. The time, success rate, and incidence of complications were compared between the two groups from the start of dosing to embryo excretion. Results: the duration from initial administration to embryo expulsion in combination group was 36.21±2.45h shorter than that in single drug group, 56.13±5.01h, P < 0.05. The combined power was 100.00% higher than that of the single drug group (76.00%, P < 0.05). There were no serious complications in the two groups, including 2 cases of low fever in the monotherapy group and 3 cases of mild diarrhea and nausea in the combination group (P > 0.05). Conclusion: the clinical effect of ethacridine combined with MFP in the treatment of induced labor in the second trimester is better than ethacridine, which can improve the success rate and shorten the time of induced labor, with high safety.
基金supported by the National Natural Science Foundation of China(No.41276010)the Ministry of Education of China(No.20130132130002)
文摘A laboratory experiment was conducted inside a wind wave tank to investigate the wave induced turbulence. In this experiment, the wave surface elevation and velocity beneath the water surface were measured simultaneously to investigate the relation between the wave status and wave induced turbulence. The profile of the turbulent dissipation rate and Reynolds stress were calculated using experimental data. The effect of the wave status on turbulence is investigated with regard to the wind wave, swell, and mixed wave conditions. It was depicted that the turbulence decreased with increasing depth from the water surface and that the turbulence that was induced by a wave with larger wavelength and wave height is much stronger for the same wave status. Finally, we observed that the wind wave is more effective in activating the wave induced turbulence.
文摘Background: Induction of labor is the stimulation of the uterus to initiate the labor process whether by administering oxytocin, prostaglandin or reputing the membrane [1]. It was realized that the number of induction of labor patients was thought to be increasing in comparison with the spontaneous labor patients. Therefore, the complications of induced labor were higher. A detailed analysis was needed to confirm that. Objective: The aim of the study is to analyze the outcomes between spontaneous versus induced labor. Materials and Methods: A retrospective analysis was conducted at our tertiary care university hospital, in the period from December 2015 to December 2016 when 311 women were divided into two groups: group 1, women who had spontaneous labor (n = 106) compared with group 2, women who were labor induced (n = 205). Complications of pregnancy, delivery type, tear, episiotomy, blood transfusion and instruments used were analyzed retrospectively. Results: The mean ± SD of baseline characteristics, like age, height, weight, BMI and hemoglobin level for all study samples was 28.59 ± 5.95 years, 1.58 ± 0.06 m, 71.77 ± 13.42 kg, 28.59 ± 5.89 kg/m2 and 11.08 ± 1.45 g/dl respectively. A statistically significant difference was noticed in the duration of labor between spontaneous and induced labor (95% CI: 9.194 - 152.130;p-value 0.004 and OR: 0.239). There was no significant difference in complications, delivery type (Spontaneous Vaginal Delivery (SVD) or other), blood transfusion, and instrument used between women who had spontaneous labor versus induced labor. However, significant differences in tear (95% CI: 4.354 - 0.996;p-value 0.035) and episiotomy (95% CI: 0.928 - 0.224;p-value 0.028) were found between the two groups. In conclusion, the induced labor was found to be associated with high incidence of duration of labor, tear and episiotomy. Patients should always be counseled when there it is an option between the two delivery types.
文摘Misoprostol (Cytotec, Pfizer) is a prostaglandin E1 analogue widely used in labor induction. Understanding of potential risks of misoprostol in labor induction is lacking as the drug is used off-label in most countries. A 35-year-old G3P2 woman with post-date pregnancy at 40 + 3 weeks was induced using titrated oral misoprostol. Following delivery, post-partum hemorrhage was noted and, upon discovery of a uterine wall rupture due to congenital weakness of the myometrium, emergency abdominal total hysterectomy was conducted. Following surgery, the patient made a full recovery and was discharged. The main contraindications for misoprostol in labor induction are a scarred uterus or multipara greater than 4. Uterine wall weakness should be considered as a potential contraindication. Extreme vigilance is required in use of misoprostol for labor induction.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.51279187 and 41174157)the Fundamental Research Funds for the Central Universities(Grant No.201262005)
文摘The dynamic response of two flexible model risers in tandem arrangement immersed in a stepped current was analyzed. The risers, with an external diameter of 20 mm and a total length of 6200 mm, had an aspect ratio of 310. They were hinged to the support structure at the center-to-center distances away 3-12 times the external diameter. The top 1200 mm was exposed to a uniform current at a speed which was up to 0.9 m/s（the Reynolds number was 18000） and the rest in still water. The dynamic responses, which were obtained through the Fiber Bragg Grating strain gauges mounted on the surface, were analyzed by studying the cross-flow amplitudes and modal weights. The cross-flow vibration were observed up to the third mode, and the modal transformation from the second mode to the third mode was clearly observed. The experiment confirmed that the typical vortex-induced vibration（VIV） had occurred on the up-stream riser. But for the down-stream riser, the main excitation mechanism was wake-induced vibration（WIV）. The modal transformation of WIV was more complex than that of VIV, which might be helpful for other researchers to study the interference effect.
基金supported by National Natural Science Foundation of China(Nos.61127017,61378047,61205216,61178009,61108030,61475093,and 61275213)the National Key Technology R&D Program of China(No.2013BAC14B01)+2 种基金the 973 Program of China(No.2012CB921603)the Shanxi Natural Science Foundation,China(Nos.2013021004-1,2012021022-1)the Shanxi Scholarship Council of China(Nos.2013-011 and 2013-01)
文摘Determination of the chemical composition of cement and ratio values of clinker plays an important role in cement plants as part of the optimal process control and product quality evaluation. In the present paper, a laboratory laser-induced breakdown spectroscopy （LIBS） apparatus mainly comprising a sealed optical module and an analysis chamber has been designed for possible application in cement plants for on-site quality analysis of cement. Emphasis is placed on the structure and operation of the LIBS apparatus, the sealed optical path, the temperature controlled spectrometer, the sample holder, the proper calibration model established for minimizing the matrix effects, and a correction method proposed for overcoming the ＇drift＇ obstacle. Good agreement has been found between the laboratory measurement results from the LIBS method and those from the traditional method. The absolute measurement errors presented here for oxides analysis are within 0.5%, while those of ratio values are in the range of 0.02 to 0.05. According to the obtained results, this laboratory LIBS apparatus is capable of performing reliable and accurate, composition and proximate analysis of cement and is suitable for application in cement plants.
文摘Radiation-induced reduction of chromium（Ⅵ）（Cr（Ⅵ） by ,γ-irradiation was studied with an initial concentration of 42 mg/L in aqueous solutions. Several factors which might affect the reduction of Cr（Ⅵ） to Cr（Ⅲ） were examined, pH of aqueous solution affects the reduction efficiency significantly. Acidic condition of aqueous solution accelerates the process. At pH 2, a reduction of 86.2% was achieved with the absorbed dose of 15 kGy, while, with the same dose, at pH 5 and 7, the reduction ofCr （Ⅵ） were only 36.3% and 22.2%, respectively. Ethanol （0.1% in V：V） and sodium carbonate （1 mmol/L） were added into the solution respectively as relatively non-toxic hydroxyl radical scavengers. Reduction rate increased greatly in the presence of ethanol at each pH. Reduction efficiency of Cr（Ⅵ） was enhanced in neutral condition with the addition of sodium carbonate, however, no enhancement was found in acidic condition. The reduction of Cr（Ⅵ） was restrained when the solution was saturated with oxygen; however, the restraint was not significant.
基金supported by the National Key R&D Program of China(2023YFA1406200)the National Natural Science Foundation of China(T2521005,12174144,12474009,12174146,and 124B2059)the Special Construction Project Fund for Shan-dong Province Taishan Scholars.
文摘Multifunctional optical responsive materials have grown increasingly pivotal in addressingthe escalating demands of sensing,detection,and anti-counterfeiting applications[1,2].These materials exhibit distinct visible optical variations upon exposure to external stimuli,such as pressure,temperature,light,solvents,pH fluctuations,or mechanical force.Fluorescent sensing and anti-counterfeiting technologies leveraging these optical responses have emerged as highly promising solutions.
基金Supported by Key Project of Jiangsu Education Science Planning"Research on the Structural Adjustment of Higher Education in Jiangsu in the Context of High-Quality Economic Development"(B/2021/01/67).
文摘In the context of the coordinated pursuit of"carbon peak and neutrality"objectives,alongside the strategy to establish a robust agricultural nation,the economic and social development of rural areas is undergoing a profound paradigm shift.The traditional rural division of labor pattern,which depends on tangible factors such as land,labor,and capital,has increasingly encountered developmental challenges characterized by diminishing marginal returns and a detrimental cycle of internal competition.The new quality productive force,centered on data,algorithms,green technologies,bioengineering,and clean energy,offers a potential pathway for the rural division of labor system to overcome the"low-level equilibrium".This force is characterized by attributes such as non-exclusivity,replicability,network collaboration,and ecological compatibility.This paper develops a three-dimensional collaborative analytical framework encompassing"technology,institution,and culture".It systematically elucidates the internal logic by which new quality productive forces drive the transformation of the rural division of labor from"quantitative factor matching"to"qualitative structural reorganization"through three principal mechanisms:technology embedding,institutional reconstruction,and cultural coupling.Furthermore,the study proposes corresponding policy recommendations,thereby offering theoretical insights to support the modernization of China s agriculture and rural areas,as well as the development of a strong agricultural country.
基金supported by the National Key R&D Program of China(2022YFD1401005).
文摘Diplodia tip blight,caused by Diplodia sapinea,is a global pine necrotic disease causing heavy economic losses to the pine industry.Chemical control,its main current management,easily induces pathogen resistance and environmental pollution,which biological control avoids.This study investigated juniper essential oil’s efficacy against the disease on Mongolian Scots pine(Pinus sylvestris var.mongolica)and its induced resistance mechanisms via pot experiments,physiological assays(defense enzyme activities,resistant substances)and metabolomic sequencing(secondary metabolites).Results showed varied efficacy:three foliar sprays of 10μL mL^(-1) oil achieved the best control phenylalanine ammonia-lyase(PAL),polyphenol oxidase(82.9%).The 20μL mL^(-1) treatment significantly increased(PPO)activities,and contents of lignin,flavonoids and total phenolics.Metabolomic analysis showed 326 upregulated and 527 downregulated different metabolites in essential oilinduced and pathogen-inoculated pines,compared to 483 upregulated and 277 downregulated metabolites in noninduced but inoculated pines.The differentially expressed metabolites in treated pines were primarily enriched in pathways related to amino acid metabolism and plant secondary metabolite biosynthesis,with notably increased expression levels of ferulic acid,scopoletin,pipecolic acid,D-proline,and DL-arginine.Therefore,juniper essential oil protects against D.sapinea by inducing systemic acquired resistance in Mongolian Scots pine.In conclusion,juniper essential oil controls D.sapinea by inducing systemic acquired resistance(SAR)in Mongolian Scots pine,clarifying the molecular mechanism and supporting biological control of the disease.
基金funded by Joint Funds of the National Natural Science Foundation of China(Grant No.U23A20671)the Major Project of Inner Mongolia Science and Technology(Grant No.2021ZD0034)the Creative Groups of Natural Science Foundation of Hubei Province,China(Grant No.2021CFA030).
文摘While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model incorporating rate-and-state friction laws to investigate fault reactivation mechanisms during early-stage CO_(2)injection.The competing effects of pore pressure diffusion and fluid pressurization are systematically investigated,considering three key factors:permeability variations within fault damage zones,normal stress variation coefficients,and injection parameters.Numerical simulations reveal that slower CO_(2)migration causes limited pressure perturbation(<0.3 MPa over 15 d)compared to single-phase fluid injection.Fluid pressurization enhances fault strength and delays reactivation,though this stabilizing effect diminishes in low-permeability damage zones.Highly permeable damage zones promote larger rupture areas despite strengthening from pressurization,as reduced effective stress accelerates failure.Paradoxically,while fluid pressurization increases fault strength,it simultaneously elevates seismic risk through amplified stress drops during slip events.Temporal analysis shows that fluid pressurization dominates initial fault response,while sustained pore pressure diffusion ultimately drives reactivation.Increased normal stress variation coefficients and injection rates accelerate localized rupture initiation but restrict propagation due to non-critically stressed states.This discrepancy demonstrates that regions with positive Coulomb failure stress changes do not correlate well with actual slip zones.These findings highlight the critical interplay between transient pressurization effects and progressive pressure diffusion during early CO_(2)injection phases,providing crucial insights for seismic risk management in CO_(2)storage projects.
基金supported by the National Natural Science Foundation of China[Grant NO.42401465 and 42401464]Yunnan Fundamental Research Projects[Grant NO.202501AT070343,202401AU070169 and 202401CF070161]+1 种基金Natural Science Fund of Kunming University of Science and Technology(KKZ3202421125)Yunnan Provincial Talent Project“High-level Talent Training Support Plan”[YNWR-QNBJ-2020-031]。
文摘Accurate phenological information is essential for measuring ecosystem dynamics and carbon uptake.Southwest China is one of the country's largest terrestrial carbon sink regions and plays a crucial role in carbon peaking and neutrality.However,its complex terrain,fragile ecosystem,and variable climate challenge carbon sink stability.Vegetation phenology significantly impacts carbon absorption and release,making accurate phenological data essential for understanding carbon sequestration dynamics.The widespread distribution of evergreen forests and their weak seasonal variation in canopy introduce significant uncertainties in extracting phenology using traditional remote sensing information in this region.These limitations can lead to inaccurate assessments of carbon sink dynamics.Therefore,precise phenology extraction and analysis are vital for improving ecosystem dynamics and the carbon cycle in Southwest China.Firstly,we employed different ways to evaluate the ability of solar-induced chlorophyll fluorescence(SIF)and traditional remote sensing information to extract phenology.Secondly,based on SIF,we analyzed the spatial and temporal changes in the start of the growing season(SOS),the end of the growing season(EOS),and the length of the growing season(LOS)from 2001 to 2020.Finally,we systematically analyzed the response of SOS and EOS to five preseason climatic factors.The results showed that(1)SIF outperformed traditional remote sensing information in extracting phenology.(2)Vegetation phenology exhibited significant spatial heterogeneity.Moreover,SOS,EOS,and LOS showed trends of advancement,delay,and extension both overall and across all vegetation types.(3)Precipitation was the main factor influencing SOS,while surface downward solar radiation and mean temperature were the main factors affecting EOS,and the phenology of different vegetation types showed a great difference in response to preseason climate factors.These findings improve our understanding of vegetation phenology and its dynamics over Southwest China.
文摘CO_(2)utilization powered by sustainable energy offers a promising route to mitigate carbon emissions while producing value-added chemicals[1].Among these pathways,CO_(2)hydrogenation is especially attractive because it integrates renewable H 2 with carbon resources,which have achieved notable success in producing methanol,CO,etc.[2,3].
基金supported by the National Key Research and Development Program of China(Grant No.2023YFC3707900)National Natural Science Foundation of China(Grant No.42230710,42525201)Key task project for joint research and development of the Yangtze River Delta Science and Technology Innovation Community(Grant No.2022CSJGG1200).
文摘Microbially induced calcium carbonate precipitation(MICP)is an eco-friendly technology for soil improvement.Although numerous experiments have been conducted to solidify sand foundations using MICP,the mechanisms by which grain interfacial morphologies influencethe MICP process remain unclear.This study utilized 3D-printed flowcells with different boundary morphologies to investigate the effects of interfacial morphologies on the MICP process.CaCO_(3)precipitation characteristics were investigated through microscopic observation and image quantificationanalysis.The results indicate that low flowvelocities near the interface promote bacterial accumulation due to reduced hydrodynamic shear forces.Rough interfaces,compared to smooth ones,enhance bacterial adsorption owing to the larger regions of low flowvelocity,increased surface area,and the formation of local eddies,which promote greater CaCO_(3)precipitation.Compared to the regions away from the interface,a higher abundance of small CaCO_(3)crystals is observed near the interface because of the high urease activity from bacteria and the reduced shear-induced entrainment due to the low flowvelocity.Besides,larger crystals also preferentially precipitate in proximity to interfaces as the low flowvelocity enhances crystal growth according to the particle attachment theory.The presence of rough interfaces further reduces flowvelocities,leading to the precipitation of larger and more densely packed CaCO_(3)crystals.Therefore,rough interfaces promote the microbially induced calcium carbonate precipitation.This work is expected to enhance the understanding of microbially induced calcium carbonate precipitation characteristics on solid surfaces such as soil grains and contribute to the optimization of MICP applications.
基金supported by the National Natural Science Foundation of China,No.32171356(to YW)Self-Support Research Projects of Shihezi University,No.ZZZC2021105(to WJ)+1 种基金Capital Medical University Natural Science Cultivation Fund,No.PYZ23044(to FQM)Beijing Municipal Natural Science Foundation,No.7244410(to JHD)。
文摘Previous research has demonstrated the feasibility of repairing nerve defects through acellular allogeneic nerve grafting with bone marrow mesenchymal stem cells.However,adult tissue–derived mesenchymal stem cells encounter various obstacles,including limited tissue sources,invasive acquisition methods,cellular heterogeneity,purification challenges,cellular senescence,and diminished pluripotency and proliferation over successive passages.In this study,we used induced pluripotent stem cell-derived mesenchymal stem cells,known for their self-renewal capacity,multilineage differentiation potential,and immunomodulatory characteristics.We used induced pluripotent stem cell-derived mesenchymal stem cells in conjunction with acellular nerve allografts to address a 10 mm-long defect in a rat model of sciatic nerve injury.Our findings reveal that induced pluripotent stem cell-derived mesenchymal stem cells exhibit survival for up to 17 days in a rat model of peripheral nerve injury with acellular nerve allograft transplantation.Furthermore,the combination of acellular nerve allograft and induced pluripotent stem cell-derived mesenchymal stem cells significantly accelerates the regeneration of injured axons and improves behavioral function recovery in rats.Additionally,our in vivo and in vitro experiments indicate that induced pluripotent stem cell-derived mesenchymal stem cells play a pivotal role in promoting neovascularization.Collectively,our results suggest the potential of acellular nerve allografts with induced pluripotent stem cell-derived mesenchymal stem cells to augment nerve regeneration in rats,offering promising therapeutic strategies for clinical translation.
基金supported by the National Natural Science Foundation of China(32525049).
文摘Concerns about the long-term safety and efficacy of glibenclamide(GLIB),a type 2 diabetes mellitus(T2DM)treatment,have been reported[1].Recent evidence indicates the gut microbiota composition significantly affects host glucose metabolism and drugbioavailability,increasingthe efficacy of T2DM therapy[2].In this context,probiotic-drug coadministration,an emerging adjunct approach for treating metabolic diseases,improves therapeutic outcomes and ameliorates side effects[3].
文摘In recent years,the obstetrics department has advocated vaginal delivery to reduce the rate of cesarean sections.However,in clinical practice,pregnant women are prone to anxiety before childbirth,making it difficult to perform a vaginal trial delivery smoothly.The combined approach of ADIET communication and delivery rehearsal for vaginal trial delivery can provide a reference for reducing prenatal anxiety,shortening labor duration,facilitating a smooth delivery,and ensuring the safety of both mothers and babies.AIM To analyze the effect of AIDET communication combined with labor rehearsal on vaginal trial delivery.METHODS A study conducted between January 2023 and December 2023 included 200 vaginal trials.Women were randomly assigned to an observation group(100 women),which received ADIET communication plus delivery intervention,and a control group(100 women),which received routine communication plus delivery intervention.This study aimed to compare antenatal anxiety status as measured using the Maternal Anxiety Scale,labor duration,delivery efficacy as assessed using the simplified Chinese version of the Childbirth Self-Efficacy Inventory,and delivery outcomes.RESULTS After the intervention,the observation group had a lower Maternal Anxiety Scale score and higher Childbirth Self-Efficacy Inventory score(P<0.05)than the control group(P<0.05),whereas the observation group had higher natural delivery,cesarean delivery,vaginal delivery,and neonatal asphyxia rates(P<0.05).CONCLUSION For women undergoing vaginal trial delivery,a combination of AIDET communication and delivery rehearsal can relieve prenatal anxiety,enhance delivery efficiency,shorten labor duration,and somewhat improve delivery outcomes.
文摘In the era of digital capitalism with the explosion of data and information,human society will be greatly affected by digital capital,and all walks of life will be included in the chain of information-based labor production,giving rise to a new type of labor form called“digital labor”.This paper discusses the alienation of digital labor in the context of digital capitalism,take Marx’s theory of alienated labor as the perspective,and analyze the fourfold alienation of digital labor in terms of producing products,labor process,self-realization of laborers,and social relations by combing the historical development of digital labor.Based on the above analysis,the article proposes the logical and practical paths to crack the alienation of digital labor:improve media literacy and thinking discernment,make full use of the positive effects of digital technology,and strengthen the governance of digital platforms,in order to build a fairer and more shared digital labor environment,and to realize the self-emancipation of laborers and the healthy development of the digital economy.
基金result of the“Research on ESG Supply Chain Governance and Labor Rights Protection”(Project Number SUFE-ESG-20250315)a general subject project of the Fullgoal Institute for ESG Research,SUFE in 2025.
文摘Labor provisions have become a fundamental trade rule in regional and bilateral trade agreements.Although China’s legislation on pilot Free Trade Zones includes content related to labor protection,it primarily aligns with labor indicators in“Doing Business”,the assessment of business situations issued by the World Bank.It differs from the labor rights protection focus emphasized in trade agreements.The latest strategic documents issued by the State Council of China have addressed this issue to fully achieve the goal of aligning Free Trade Zones with high-standard trade agreements.Building on the development of Free Trade Zone legislation and domestic labor law governance,China should proactively explore a tailored approach to labor provisions in Free Trade Agreements.In this approach,it should explicitly define the“baseline”and“ceiling”for labor provisions during negotiations and,within this framework,establish benchmarks for labor rights protection,enforcement mechanisms,and cross-border regulatory mechanisms suited to the specific conditions of the agreement parties.
文摘BACKGROUND The discovery of induced pluripotent stem cells revolutionized regenerative medicine,providing a source for generating induced pluripotent stem cell-derived mesenchymal stem cells(iMSCs).AIM To evaluate and compare five iMSC differentiation protocols,assessing their efficiency,phenotypic characteristics,and functional properties relative to primary mesenchymal stem cells(MSCs).METHODS Five iMSC differentiation protocols were assessed:SB431542-based differentiation(iMSC1,iMSC3),an iMatrix-free method(iMSC2),growth factor supplementation(iMSC4),and embryoid body formation with retinoic acid(EB-iMSC).iMSC identity was confirmed according to the International Society for Cell&Gene Therapy 2006 criteria,requiring expression of surface markers(CD105,CD73,CD90)and absence of pluripotency markers.Functional assays were conducted to evaluate differentiation potential(osteogenic and adipogenic),proliferation,mitochondrial function,reactive oxygen species,senescence,and migration.RESULTS All iMSC types expressed MSC markers and lacked pluripotency markers.EBiMSC and iMSC2 showed enhanced osteogenesis(runt-related transcription factor 2;P≤0.01 and P≤0.0001,respectively),while adipogenic potential was reduced in iMSC2(Adipsin;P≤0.01)and EB-iMSC(Adipsin and peroxisome proliferatoractivated receptor gamma;P≤0.0001 and P≤0.01,respectively).Proliferation was comparable or superior to bone marrow MSCs,except in iMSC1,with iMSC4 showing the highest rate(MTT assay;P values ranged from 0.01 to 0.001).Despite reduced mitochondrial health in iMSC3 and iMSC4(P≤0.001),reactive oxygen species levels were lower in all iMSCs(P values ranged from 0.001 to 0.0001),and senescence was significantly reduced in all iMSCs with the exception of iMSC1(P values ranged from 0.01 to 0.0001).Migration was most reduced in iMSC4(P≤0.001 at 24 hours and P≤0.0001 at 48 hours).CONCLUSION While all protocols generated functional iMSCs,variations in differentiation,proliferation,and function emphasize the impact of protocol selection.These findings contribute to optimizing iMSC generation for research and clinical applications.
