The development of depression is directly correlated with the concentration of 5-hydroxytryptophan(5-HTP).It has been demonstrated that Lactobacillus increases 5-HTP secretion,however,it is unclear how this elevated 5...The development of depression is directly correlated with the concentration of 5-hydroxytryptophan(5-HTP).It has been demonstrated that Lactobacillus increases 5-HTP secretion,however,it is unclear how this elevated 5-HTP secretion results in antidepressant benefits.Mice exposed to chronic unpredictable mild stress(CUMS)were administered L.pentosus LPQ1 by gavage for 35 days.According to our findings,CUMS-exposed mice showed an improvement in body weight when treated with L.pentosus LPQ1.Furthermore,we discovered that in mice given CUMS,L.pentosus LPQ1 raised neurotransmitter levels and decreased behavior resembling depression.Also,L.pentosus LPQ1 upregulated hippocampal 5-HT1A,phosphorylated cyclic adenosine monophosphate responsive element binding protein(p-CREB)/CREB,brain-derived neurotrophic factor(BDNF),and phosphorylated tropomyosin kinase B(p-TrκB/TrκB)expression of CUMS-exposed mice.Additionally,L.pentosus LPQ1 is associated with an increase in the number of helpful bacteria in the gut microbiota,including Unclassified-f-Lachnospiracea,Lachnospiraceae-NK4A136-group,Eubacterium_xylanophilum_group.In summary,L.pentosus LPQ1 attenuated CUMS-induced depression by restoring 5-HTP-related 5-HT1A-CREB-BDNF-TrκB signaling.Interestingly,the improvement of depressive-like behavior by L.pentosus LPQ1 is also related to the improvement of gut microbiota dysbiosis.According to our research,L.pentosus LPQ1 may be a useful therapeutic alternative for depressed people.展开更多
基金supported by Yu Yang(Faculty of Psychology,Southwest University)supported by the Major Science and Technology Special Projects in Tibet Autonomous Region(XZ202201ZD0001N)+3 种基金University Innovation Research Group in Chongqing(CXQT21007)Key Construction Disciplines of Traditional Chinese Medicine in Chongqing(2021–4322190044)Sichuan Province Key Research and Development Program(2024YFHZ0077)Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202300204).
文摘The development of depression is directly correlated with the concentration of 5-hydroxytryptophan(5-HTP).It has been demonstrated that Lactobacillus increases 5-HTP secretion,however,it is unclear how this elevated 5-HTP secretion results in antidepressant benefits.Mice exposed to chronic unpredictable mild stress(CUMS)were administered L.pentosus LPQ1 by gavage for 35 days.According to our findings,CUMS-exposed mice showed an improvement in body weight when treated with L.pentosus LPQ1.Furthermore,we discovered that in mice given CUMS,L.pentosus LPQ1 raised neurotransmitter levels and decreased behavior resembling depression.Also,L.pentosus LPQ1 upregulated hippocampal 5-HT1A,phosphorylated cyclic adenosine monophosphate responsive element binding protein(p-CREB)/CREB,brain-derived neurotrophic factor(BDNF),and phosphorylated tropomyosin kinase B(p-TrκB/TrκB)expression of CUMS-exposed mice.Additionally,L.pentosus LPQ1 is associated with an increase in the number of helpful bacteria in the gut microbiota,including Unclassified-f-Lachnospiracea,Lachnospiraceae-NK4A136-group,Eubacterium_xylanophilum_group.In summary,L.pentosus LPQ1 attenuated CUMS-induced depression by restoring 5-HTP-related 5-HT1A-CREB-BDNF-TrκB signaling.Interestingly,the improvement of depressive-like behavior by L.pentosus LPQ1 is also related to the improvement of gut microbiota dysbiosis.According to our research,L.pentosus LPQ1 may be a useful therapeutic alternative for depressed people.
