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血清SAA、LP-PLA2、Tau及ChE与脑梗死后血管性认知障碍相关研究 被引量:2
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作者 赵宁博 王昌铭 《标记免疫分析与临床》 2025年第4期792-798,880,共8页
目的探讨淀粉样蛋白A(SAA)、血清脂蛋白相关磷脂酶A2(LP-PLA2)、Tau蛋白及血清胆碱酯酶(ChE)与脑梗死后血管性认知功能障碍(VCI)的关系。方法选择2022年12月至2024年1月在解放军联勤保障部队989医院神经内科住院患者,根据简易智力状态... 目的探讨淀粉样蛋白A(SAA)、血清脂蛋白相关磷脂酶A2(LP-PLA2)、Tau蛋白及血清胆碱酯酶(ChE)与脑梗死后血管性认知功能障碍(VCI)的关系。方法选择2022年12月至2024年1月在解放军联勤保障部队989医院神经内科住院患者,根据简易智力状态检查量表(MMSE)将其分为非VCI组、VCI非痴呆组和VCI痴呆组,选择同时期体检健康者为对照组,对比各组SAA、LP-PLA2、Tau、ChE水平及MMSE,分析探究SAA、LP-PLA2、Tau及ChE水平与MMSE评分相关性,同时分别检测非VCI组、VCI非痴呆组、VCI痴呆组患者发病时、发病后3个月及6个月各血清指标及MMSE评分,分析3组患者血清指标及MMSE评分变化水平。结果各组患者发病时MMSE评分及血清SAA、LP-PLA2、Tau、ChE水平组间比较,差异具有统计学意义。非VCI组患者血清SAA、LP-PLA2、Tau、ChE及MMSE评分在发病时、发病后3个月及6个月3个观察时间点差异具有统计学意义(P<0.001),VCI非痴呆组及VCI痴呆组同样满足(P<0.001)。结论血清SAA、LP-PLA2、Tau水平与脑梗死后发生VCI的风险成正比,ChE水平与发生VCI的风险成反比,具有一定诊断价值,且4者联合诊断效能大于独立血清诊断效能。血清SAA、LP-PLA2、Tau及ChE对脑梗死后发生认知功能障碍具有一定的诊断价值。 展开更多
关键词 脑梗死 血管性认知功能障碍 LP-PLA2 SAA TAU CHE
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Application of Surrogate Modeling in Stochastic Analysis of an Ogee Spillway Structure
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作者 Kaywan Othman Ahmed Nazim Abdul Nariman Rawand Sardar Abdulrahman 《International Journal of Mechanical System Dynamics》 2025年第2期290-311,共22页
This study investigates the hydraulic performance of an Ogee spillway under varying flow rate conditions,gate opening heights,and spillway widths.Numerical simulations using Flow-3D,incorporating the(k-ε)turbulence m... This study investigates the hydraulic performance of an Ogee spillway under varying flow rate conditions,gate opening heights,and spillway widths.Numerical simulations using Flow-3D,incorporating the(k-ε)turbulence model and Large Eddy Simulation(LES),were employed alongside surrogate models using MATLAB codes and LP-TAU to predict flow behavior.The analysis focused on pressure distribution,water velocity,and shear stress variations across seven sensor locations along the spillway.Results indicate that pressure distribution generally decreases with increasing flow rate but rises with greater gate opening height or spillway width.A reduction in gate opening height lowers the pressure in the initial region but increases it downstream.Two negative pressure zones were identified,one at the Ogee curve and another at the downstream sloping section,highlighting potential cavitation risks.Comparisons with experimental data confirmed a strong correlation,with minor discrepancies in specific sensors under varying conditions.The study demonstrates that numerical modeling,particularly using the(k-ε)turbulence model in Flow-3D,effectively assesses the hydraulic performance of controlled Ogee-type spillways. 展开更多
关键词 controlled Ogee-type spillway Flow-3D k-εmodel LES model lp-tau MATLAB
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