Apowerful swing, the swish of a titanium club and the sweet crisp smackas it connects with a white dimpled ball. Golf, the sport associated with money,business deals and all the finer things in life.And in an age wher...Apowerful swing, the swish of a titanium club and the sweet crisp smackas it connects with a white dimpled ball. Golf, the sport associated with money,business deals and all the finer things in life.And in an age where any competitive展开更多
Scan here for complete Guangzhou listings Want to see all restaurants,hotels and more in Guangzhou?Check out www.thatsmags.com or download our app by seanning the QR code here.
Scan here for complete Guangzhou listings Want to see all restaurants,hotels and more in Guang-zhou?Check out www.thatsmags.com or download our app by scanning the QR code here.
Canton Disco This traditional Cantonese restaurant concept with a contemporary update at its fore offers a high energy atmosphere,addictive cuisine and unpretentious service that paints a perfect picture of modern Sha...Canton Disco This traditional Cantonese restaurant concept with a contemporary update at its fore offers a high energy atmosphere,addictive cuisine and unpretentious service that paints a perfect picture of modern Shanghai.2F,Heritage Building,The Shanghai EDITION,199 Nanjing Dong Lu,by Jiangxi Zhong Lu(53689521)5.30-10.30pm.展开更多
Canton Disco This traditional Cantonese restaurant concept with a contemporary update at its fore offers a high energy atmosphere,addictive cuisine and unpretentious service that paints a perfect picture of modern Sha...Canton Disco This traditional Cantonese restaurant concept with a contemporary update at its fore offers a high energy atmosphere,addictive cuisine and unpretentious service that paints a perfect picture of modern Shanghai.2F,Heritage Building,The Shanghai EDITION,199 Nanjing Dong Lu,by Jiangxi Zhong Lu(53689521)5.30-10.30pm.展开更多
The search for new research ideas is a central challenge for many scientists.Over the past four decades,I have formed opinions on methods for discerning promising paths from how my own work has advanced in fits and st...The search for new research ideas is a central challenge for many scientists.Over the past four decades,I have formed opinions on methods for discerning promising paths from how my own work has advanced in fits and starts.I list five criteria whose relevance and utility I have assessed based on my checkered history of research.展开更多
BACKGROUND The CAR-OLT score predicts major adverse cardiovascular events 1 year after liver transplant(LT).AIM To test the hypothesis that the CAR-OLT score may help avoid cardiac stress tests in LT candidates.METHOD...BACKGROUND The CAR-OLT score predicts major adverse cardiovascular events 1 year after liver transplant(LT).AIM To test the hypothesis that the CAR-OLT score may help avoid cardiac stress tests in LT candidates.METHODS This retrospective single-center cohort study included all adult patients undergoing elective evaluation for first cadaveric donor orthotopic LT for liver cirrhosis with or without hepatocellular carcinoma at Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricerca e Cura a Carattere Scientifico in Rome,Italy.Cardiac contraindications for LT listing were defined after a center-specific cardiac workup,which included cardiac stress tests for most patients.The diagnostic accuracy of the CAR-OLT score was evaluated using the area under the receiver operating characteristic(AUROC)method.RESULTS A total of 342 LT candidates were evaluated between 2015 and 2019,with a moderate cardiovascular risk profile(37%diabetes,34%hypertension,22%obesity).Of these,80(23%)candidates underwent coronary angiography.Twenty-one(6%)candidates were given cardiac contraindications to LT listing,48%of which were due to coronary artery disease.The CAR-OLT score predicted cardiac contraindications to LT listing with an AUROC of 0.81.The optimal cut-off for sensitivity was a CAR-OLT score≤23,which showed a 99%negative predictive value for cardiac contraindications to LT listing.A total of 84(25%)LT candidates with a CAR-OLT score≤23 underwent 87 non-invasive cardiac tests and 13 coronary angiographies pre-listing,with estimated costs of approximately 48000€.The estimated savings per patient was€574.70 for the Italian National Health System.CONCLUSION A CAR-OLT score≤23 can identify LT candidates who can be safely listed without the need for cardiac stress tests,providing time and cost savings.These findings require external validation.展开更多
Assessing the threat status of species in response to global change is critical for biodiversity monitoring and conservation efforts.However,current frameworks,even the IUCN Red List,often neglect critical factors suc...Assessing the threat status of species in response to global change is critical for biodiversity monitoring and conservation efforts.However,current frameworks,even the IUCN Red List,often neglect critical factors such as genetic diversity and the impacts of climate and land-use changes,hindering effective conservation planning.To address these limitations,we developed an enhanced extinction risk assessment framework using Diploderma lizards as a model.This framework incorporates long-term field surveys,environmental data,and land-use information to predict distributional changes for 10 recently described Diploderma species on the Qinghai-Xizang Plateau,which hold ecological significance but remain underassessed in conservation assessment.By integrating the distribution data and genetically inferred effective population sizes(Ne),we conducted scenario analyses and used a rank-sum approach to calculate Risk ranking scores(RRS)for each species.This approach revealed significant discrepancies with the IUCN Red List assessments.Notably,D.yangi and D.qilin were identified as facing the highest extinction risk.Furthermore,D.vela,D.batangense,D.flaviceps,D.dymondi,D.yulongense,and D.laeviventre,currently classified as“Least Concern”,were found to warrant reclassification as“Vulnerable”due to considerable threat from projected range contractions.Exploring the relationship between morphology and RRS revealed that traits such as snout-vent length and relative tail length could serve as potential predictors of extinction risk,offering preliminary metrics for assessing species vulnerability when comprehensive data are unavailable.This study enhances the precision of extinction risk assessment frameworks and demonstrates their capacity to refine and update risk assessments,especially for lesser-known taxa.展开更多
A graph G is called d-degenerate if every subgraph of G has a vertex of degree at most d.It was known that planar graphs are 5-degenerate and every planar graph without k-cycles for some prescribed k∈{3,5,6}is 3-dege...A graph G is called d-degenerate if every subgraph of G has a vertex of degree at most d.It was known that planar graphs are 5-degenerate and every planar graph without k-cycles for some prescribed k∈{3,5,6}is 3-degenerate.In this paper,we show that if G is a planar graph without kites and 9-or 10-cycles,then G is 3-degenerate,hence 4-choosable and list vertex 2-arborable.展开更多
The National Development and Reform Commission issued the Negative List for Market Access(2025 Edition),which covers rare earth-related areas On April 24,2025,the National Development and Reform Commission(NDRC)issued...The National Development and Reform Commission issued the Negative List for Market Access(2025 Edition),which covers rare earth-related areas On April 24,2025,the National Development and Reform Commission(NDRC)issued the Negative List for Market Access(2025 Edition).Therein,it is specified in the Item 94 from the nineteenth part of the Permit Access Category,the Catalogue of Government Approved Investment Projects(2016 Edition).展开更多
Nothofagus alessandrii forests in the Mediterranean region of Chile face significant threats from deforestation,fragmentation,wildfires,and climate change.This study investigated the temporal and spatial dynamics of N...Nothofagus alessandrii forests in the Mediterranean region of Chile face significant threats from deforestation,fragmentation,wildfires,and climate change.This study investigated the temporal and spatial dynamics of N.alessandrii populations and their implications for habitat fragmentation and connectivity.Using remote sensing data and geographic information system analysis,we assessed deforestation patterns,fragmentation metrics,and connectivity indices for different scenarios between 2009 and 2022.A reduction in the N.alessandrii forest area,extensive fragmentation,and decreased connectivity were observed over time,with wildfires exacerbating these trends.Reforestation simulations showed the potential of targeted restoration efforts to improve connectivity,especially when focusing on proximate patches.However,careful consideration of seed dispersal distances and wildfire risk is essential for effective reforestation planning.Overall,our findings underscore the urgent need for conservation interventions to preserve N.alessandrii forests and their biodiversity in Chile's coastal mountain ecosystems.A proactive and collaborative approach is essential to ensure the survival of these forests for future generations.展开更多
In the increasingly competitive construction market,the engineering quantity list pricing model,as an important way of project cost management,is of crucial significance for construction enterprises to control costs a...In the increasingly competitive construction market,the engineering quantity list pricing model,as an important way of project cost management,is of crucial significance for construction enterprises to control costs and enhance benefits.This study deeply analyzes the characteristics of engineering quantity list pricing,and elaborates on the dilemmas faced by construction enterprises in project cost control,such as lagging concepts,imperfect mechanisms,weak risk management and control,and lack of construction-stage management.Based on this,from the dimensions of strengthening management and control concepts,improving supervision mechanisms,enhancing risk management and control capabilities,and attaching importance to construction-stage cost management,this study proposes project cost management and control strategies that are in line with the actual situation of construction enterprises,aiming to promote construction enterprises to achieve scientific management and optimization of project costs under the engineering quantity list pricing model.展开更多
The learning of English academic vocabulary has been the focus of numerous studies from the time Coxhead(2000)developed the academic word list to the present day.Various researchers have emphasized the importance of p...The learning of English academic vocabulary has been the focus of numerous studies from the time Coxhead(2000)developed the academic word list to the present day.Various researchers have emphasized the importance of possessing academic vocabulary knowledge for academic success.Recognizing this importance,it is crucial for researchers,teachers,and learners to understand the progress made in academic word lists.This systematic review first identifies,describes,appraises,and synthesizes the development of academic word lists from 2000 to 2020.It then examines the methods used by researchers in developing academic word lists among 56 studies that meet the pre-established criteria.The word lists were classified based on some criteria such as word counting units,corpora types/sizes,and exclusion criteria.Limitations,suggestions for further study,and implications are also discussed.Additionally,recommendations for future word list establishment are provided to help advance the field of word list development.展开更多
Between 2016 and 2024,the Chinese government incorporated several innovative drugs into the National Reimbursement Drug List(NRDL)through price negotiations.These negotiations led to significant price reductions,which...Between 2016 and 2024,the Chinese government incorporated several innovative drugs into the National Reimbursement Drug List(NRDL)through price negotiations.These negotiations led to significant price reductions,which in turn stimulated an increase in sales.This study aimed to assess the impact of this policy on the pricing,utilization,and overall expenditure of targeted lung cancer therapies included in the NRDL.Using an interrupted time series analysis of procurement data from 698 healthcare institutions,the study evaluated both immediate and long-term effects.In terms of immediate effects,price negotiations resulted in a significant decline in the defined daily dose cost(DDDc)for all targeted therapies(P<0.05).Regarding long-term trends,a significant shift was observed only in the pricing trajectory of Gefitinib,Icotinib,and Ensartinib(P<0.05).In terms of immediate effects on drug utilization,all targeted medicines experienced a substantial increase in volume(P<0.05),except for Gefitinib and Icotinib.Over the long term,the usage of all targeted therapies exhibited a significant upward trend(P<0.05).With respect to expenditure,the immediate impact of NRDL inclusion resulted in a significant increase in spending on Afatinib,Crizotinib,Osimertinib,Alectinib,and Ensartinib(P<0.05).Over time,total spending on targeted medicines showed a significant increase(P<0.05),except for Erlotinib.Overall,NRDL price negotiations successfully reduced the economic burden on lung cancer patients,improving both accessibility and affordability of targeted therapies in China.展开更多
Image-based similar trademark retrieval is a time-consuming and labor-intensive task in the trademark examination process.This paper aims to support trademark examiners by training Deep Convolutional Neural Network(DC...Image-based similar trademark retrieval is a time-consuming and labor-intensive task in the trademark examination process.This paper aims to support trademark examiners by training Deep Convolutional Neural Network(DCNN)models for effective Trademark Image Retrieval(TIR).To achieve this goal,we first develop a novel labeling method that automatically generates hundreds of thousands of labeled similar and dissimilar trademark image pairs using accompanying data fields such as citation lists,Vienna classification(VC)codes,and trademark ownership information.This approach eliminates the need for manual labeling and provides a large-scale dataset suitable for training deep learning models.We then train DCNN models based on Siamese and Triplet architectures,evaluating various feature extractors to determine the most effective configuration.Furthermore,we present an Adapted Contrastive Loss Function(ACLF)for the trademark retrieval task,specifically engineered to mitigate the influence of noisy labels found in automatically created datasets.Experimental results indicate that our proposed model(Efficient-Net_v21_Siamese)performs best at both True Negative Rate(TNR)threshold levels,TNR 0.9 and TNR 0.95,with==respective True Positive Rates(TPRs)of 77.7%and 70.8%and accuracies of 83.9%and 80.4%.Additionally,when testing on the public trademark dataset METU_v2,our model achieves a normalized average rank(NAR)of 0.0169,outperforming the current state-of-the-art(SOTA)model.Based on these findings,we estimate that considering only approximately 10%of the returned trademarks would be sufficient,significantly reducing the review time.Therefore,the paper highlights the potential of utilizing national trademark data to enhance the accuracy and efficiency of trademark retrieval systems,ultimately supporting trademark examiners in their evaluation tasks.展开更多
The Reference Listed drug(RLD)plays a critical role in the development and research of generic medicinal products,serving as the comparator product used in the marketing authorization application of new generic medici...The Reference Listed drug(RLD)plays a critical role in the development and research of generic medicinal products,serving as the comparator product used in the marketing authorization application of new generic medicinal product and re-evaluation of generic medicinal product.In China,RLDs are sourced from various origins,but their quality and market availability can be constrained by multiple factors,including emergent issues such as nitrosamine impurities.Five classes of medicinal products have been reported to be at risk for containing nitrosamine impurities:sartan-based medicines,metformin-containing products,ranitidine medicines,rifampicin medicines,and Champix.This paper explores the control strategies implemented by drug regulatory agencies in the United States and the European Union to manage nitrosamine impurities and assesses their impact on the market availability and quality of RLDs in China.The aim is to offer valuable insights for generic drug manufacturers and regulatory bodies both domestically and internationally.展开更多
文摘Apowerful swing, the swish of a titanium club and the sweet crisp smackas it connects with a white dimpled ball. Golf, the sport associated with money,business deals and all the finer things in life.And in an age where any competitive
文摘Scan here for complete Guangzhou listings Want to see all restaurants,hotels and more in Guangzhou?Check out www.thatsmags.com or download our app by seanning the QR code here.
文摘Scan here for complete Guangzhou listings Want to see all restaurants,hotels and more in Guang-zhou?Check out www.thatsmags.com or download our app by scanning the QR code here.
文摘Canton Disco This traditional Cantonese restaurant concept with a contemporary update at its fore offers a high energy atmosphere,addictive cuisine and unpretentious service that paints a perfect picture of modern Shanghai.2F,Heritage Building,The Shanghai EDITION,199 Nanjing Dong Lu,by Jiangxi Zhong Lu(53689521)5.30-10.30pm.
文摘Canton Disco This traditional Cantonese restaurant concept with a contemporary update at its fore offers a high energy atmosphere,addictive cuisine and unpretentious service that paints a perfect picture of modern Shanghai.2F,Heritage Building,The Shanghai EDITION,199 Nanjing Dong Lu,by Jiangxi Zhong Lu(53689521)5.30-10.30pm.
文摘The search for new research ideas is a central challenge for many scientists.Over the past four decades,I have formed opinions on methods for discerning promising paths from how my own work has advanced in fits and starts.I list five criteria whose relevance and utility I have assessed based on my checkered history of research.
文摘BACKGROUND The CAR-OLT score predicts major adverse cardiovascular events 1 year after liver transplant(LT).AIM To test the hypothesis that the CAR-OLT score may help avoid cardiac stress tests in LT candidates.METHODS This retrospective single-center cohort study included all adult patients undergoing elective evaluation for first cadaveric donor orthotopic LT for liver cirrhosis with or without hepatocellular carcinoma at Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricerca e Cura a Carattere Scientifico in Rome,Italy.Cardiac contraindications for LT listing were defined after a center-specific cardiac workup,which included cardiac stress tests for most patients.The diagnostic accuracy of the CAR-OLT score was evaluated using the area under the receiver operating characteristic(AUROC)method.RESULTS A total of 342 LT candidates were evaluated between 2015 and 2019,with a moderate cardiovascular risk profile(37%diabetes,34%hypertension,22%obesity).Of these,80(23%)candidates underwent coronary angiography.Twenty-one(6%)candidates were given cardiac contraindications to LT listing,48%of which were due to coronary artery disease.The CAR-OLT score predicted cardiac contraindications to LT listing with an AUROC of 0.81.The optimal cut-off for sensitivity was a CAR-OLT score≤23,which showed a 99%negative predictive value for cardiac contraindications to LT listing.A total of 84(25%)LT candidates with a CAR-OLT score≤23 underwent 87 non-invasive cardiac tests and 13 coronary angiographies pre-listing,with estimated costs of approximately 48000€.The estimated savings per patient was€574.70 for the Italian National Health System.CONCLUSION A CAR-OLT score≤23 can identify LT candidates who can be safely listed without the need for cardiac stress tests,providing time and cost savings.These findings require external validation.
基金supported by the Second Tibetan Plateau Scientific Expedition and Research Program (STEP,2019QZKK0402)Science and Technology Plan Project of Xizang Autonomous Region to Y.Q. (XZ202201ZY0030G)National Natural Science Foundation of China (32201424 to Z.Y.L.and 31872233 to Y.Q.)。
文摘Assessing the threat status of species in response to global change is critical for biodiversity monitoring and conservation efforts.However,current frameworks,even the IUCN Red List,often neglect critical factors such as genetic diversity and the impacts of climate and land-use changes,hindering effective conservation planning.To address these limitations,we developed an enhanced extinction risk assessment framework using Diploderma lizards as a model.This framework incorporates long-term field surveys,environmental data,and land-use information to predict distributional changes for 10 recently described Diploderma species on the Qinghai-Xizang Plateau,which hold ecological significance but remain underassessed in conservation assessment.By integrating the distribution data and genetically inferred effective population sizes(Ne),we conducted scenario analyses and used a rank-sum approach to calculate Risk ranking scores(RRS)for each species.This approach revealed significant discrepancies with the IUCN Red List assessments.Notably,D.yangi and D.qilin were identified as facing the highest extinction risk.Furthermore,D.vela,D.batangense,D.flaviceps,D.dymondi,D.yulongense,and D.laeviventre,currently classified as“Least Concern”,were found to warrant reclassification as“Vulnerable”due to considerable threat from projected range contractions.Exploring the relationship between morphology and RRS revealed that traits such as snout-vent length and relative tail length could serve as potential predictors of extinction risk,offering preliminary metrics for assessing species vulnerability when comprehensive data are unavailable.This study enhances the precision of extinction risk assessment frameworks and demonstrates their capacity to refine and update risk assessments,especially for lesser-known taxa.
文摘A graph G is called d-degenerate if every subgraph of G has a vertex of degree at most d.It was known that planar graphs are 5-degenerate and every planar graph without k-cycles for some prescribed k∈{3,5,6}is 3-degenerate.In this paper,we show that if G is a planar graph without kites and 9-or 10-cycles,then G is 3-degenerate,hence 4-choosable and list vertex 2-arborable.
文摘The National Development and Reform Commission issued the Negative List for Market Access(2025 Edition),which covers rare earth-related areas On April 24,2025,the National Development and Reform Commission(NDRC)issued the Negative List for Market Access(2025 Edition).Therein,it is specified in the Item 94 from the nineteenth part of the Permit Access Category,the Catalogue of Government Approved Investment Projects(2016 Edition).
基金funded by Universidad Cato lica del MauleProyectos de Investigacio n con Financiamiento Interno 2022 línea Fortalecimiento Fondecyt Regular。
文摘Nothofagus alessandrii forests in the Mediterranean region of Chile face significant threats from deforestation,fragmentation,wildfires,and climate change.This study investigated the temporal and spatial dynamics of N.alessandrii populations and their implications for habitat fragmentation and connectivity.Using remote sensing data and geographic information system analysis,we assessed deforestation patterns,fragmentation metrics,and connectivity indices for different scenarios between 2009 and 2022.A reduction in the N.alessandrii forest area,extensive fragmentation,and decreased connectivity were observed over time,with wildfires exacerbating these trends.Reforestation simulations showed the potential of targeted restoration efforts to improve connectivity,especially when focusing on proximate patches.However,careful consideration of seed dispersal distances and wildfire risk is essential for effective reforestation planning.Overall,our findings underscore the urgent need for conservation interventions to preserve N.alessandrii forests and their biodiversity in Chile's coastal mountain ecosystems.A proactive and collaborative approach is essential to ensure the survival of these forests for future generations.
文摘In the increasingly competitive construction market,the engineering quantity list pricing model,as an important way of project cost management,is of crucial significance for construction enterprises to control costs and enhance benefits.This study deeply analyzes the characteristics of engineering quantity list pricing,and elaborates on the dilemmas faced by construction enterprises in project cost control,such as lagging concepts,imperfect mechanisms,weak risk management and control,and lack of construction-stage management.Based on this,from the dimensions of strengthening management and control concepts,improving supervision mechanisms,enhancing risk management and control capabilities,and attaching importance to construction-stage cost management,this study proposes project cost management and control strategies that are in line with the actual situation of construction enterprises,aiming to promote construction enterprises to achieve scientific management and optimization of project costs under the engineering quantity list pricing model.
文摘The learning of English academic vocabulary has been the focus of numerous studies from the time Coxhead(2000)developed the academic word list to the present day.Various researchers have emphasized the importance of possessing academic vocabulary knowledge for academic success.Recognizing this importance,it is crucial for researchers,teachers,and learners to understand the progress made in academic word lists.This systematic review first identifies,describes,appraises,and synthesizes the development of academic word lists from 2000 to 2020.It then examines the methods used by researchers in developing academic word lists among 56 studies that meet the pre-established criteria.The word lists were classified based on some criteria such as word counting units,corpora types/sizes,and exclusion criteria.Limitations,suggestions for further study,and implications are also discussed.Additionally,recommendations for future word list establishment are provided to help advance the field of word list development.
基金Research on Innovative Method of Drug Rational Use Supervision Decision Based on Big Data of Medical Insurance(Grant No.82273899)。
文摘Between 2016 and 2024,the Chinese government incorporated several innovative drugs into the National Reimbursement Drug List(NRDL)through price negotiations.These negotiations led to significant price reductions,which in turn stimulated an increase in sales.This study aimed to assess the impact of this policy on the pricing,utilization,and overall expenditure of targeted lung cancer therapies included in the NRDL.Using an interrupted time series analysis of procurement data from 698 healthcare institutions,the study evaluated both immediate and long-term effects.In terms of immediate effects,price negotiations resulted in a significant decline in the defined daily dose cost(DDDc)for all targeted therapies(P<0.05).Regarding long-term trends,a significant shift was observed only in the pricing trajectory of Gefitinib,Icotinib,and Ensartinib(P<0.05).In terms of immediate effects on drug utilization,all targeted medicines experienced a substantial increase in volume(P<0.05),except for Gefitinib and Icotinib.Over the long term,the usage of all targeted therapies exhibited a significant upward trend(P<0.05).With respect to expenditure,the immediate impact of NRDL inclusion resulted in a significant increase in spending on Afatinib,Crizotinib,Osimertinib,Alectinib,and Ensartinib(P<0.05).Over time,total spending on targeted medicines showed a significant increase(P<0.05),except for Erlotinib.Overall,NRDL price negotiations successfully reduced the economic burden on lung cancer patients,improving both accessibility and affordability of targeted therapies in China.
基金funded by the Institute of InformationTechnology,VietnamAcademy of Science and Technology(project number CSCL02.02/22-23)“Research and Development of Methods for Searching Similar Trademark Images Using Machine Learning to Support Trademark Examination in Vietnam”.
文摘Image-based similar trademark retrieval is a time-consuming and labor-intensive task in the trademark examination process.This paper aims to support trademark examiners by training Deep Convolutional Neural Network(DCNN)models for effective Trademark Image Retrieval(TIR).To achieve this goal,we first develop a novel labeling method that automatically generates hundreds of thousands of labeled similar and dissimilar trademark image pairs using accompanying data fields such as citation lists,Vienna classification(VC)codes,and trademark ownership information.This approach eliminates the need for manual labeling and provides a large-scale dataset suitable for training deep learning models.We then train DCNN models based on Siamese and Triplet architectures,evaluating various feature extractors to determine the most effective configuration.Furthermore,we present an Adapted Contrastive Loss Function(ACLF)for the trademark retrieval task,specifically engineered to mitigate the influence of noisy labels found in automatically created datasets.Experimental results indicate that our proposed model(Efficient-Net_v21_Siamese)performs best at both True Negative Rate(TNR)threshold levels,TNR 0.9 and TNR 0.95,with==respective True Positive Rates(TPRs)of 77.7%and 70.8%and accuracies of 83.9%and 80.4%.Additionally,when testing on the public trademark dataset METU_v2,our model achieves a normalized average rank(NAR)of 0.0169,outperforming the current state-of-the-art(SOTA)model.Based on these findings,we estimate that considering only approximately 10%of the returned trademarks would be sufficient,significantly reducing the review time.Therefore,the paper highlights the potential of utilizing national trademark data to enhance the accuracy and efficiency of trademark retrieval systems,ultimately supporting trademark examiners in their evaluation tasks.
基金Subject construction funding project of Institute for Chemical Drug Control(Grant No.2024HYZX42)in National Institutes for Food and Drug Control,Beijing,China。
文摘The Reference Listed drug(RLD)plays a critical role in the development and research of generic medicinal products,serving as the comparator product used in the marketing authorization application of new generic medicinal product and re-evaluation of generic medicinal product.In China,RLDs are sourced from various origins,but their quality and market availability can be constrained by multiple factors,including emergent issues such as nitrosamine impurities.Five classes of medicinal products have been reported to be at risk for containing nitrosamine impurities:sartan-based medicines,metformin-containing products,ranitidine medicines,rifampicin medicines,and Champix.This paper explores the control strategies implemented by drug regulatory agencies in the United States and the European Union to manage nitrosamine impurities and assesses their impact on the market availability and quality of RLDs in China.The aim is to offer valuable insights for generic drug manufacturers and regulatory bodies both domestically and internationally.
