A novel series of Mn^(4+)and Eu^(3+)co-doped double-perovskite Ca_(2)ScNbO_(6)(CSNO)phosphor was synthesized in this work.The phase structure and photoluminescence properties were systematically researched.Due to the ...A novel series of Mn^(4+)and Eu^(3+)co-doped double-perovskite Ca_(2)ScNbO_(6)(CSNO)phosphor was synthesized in this work.The phase structure and photoluminescence properties were systematically researched.Due to the different thermal quenching properties of Mn^(4+)and Eu^(3+)ions,a dual-mode temperature measurement technique over a wide temperature range was established.The CSNO phosphor co-doped with Mn^(4+)and Eu^(3+)ions has a self-calibrated effect due to the different thermal quenching effects of Mn^(4+)and Eu^(3+)ions.The maximum relative sensitivity(S_(R1,R2))values of the CSNO:0.1 mol%Mn^(4+)/0.5 mol%Eu^(3+)phosphor are determined to be 1.92%/K and 1.76%/K at 523 K,under excitation at 296 and 396 nm,respectively.Additionally,the temperature-dependent lifetime of Mn^(4+)indicates that the maximum S_(R3,R4) values for the synthesized phosphors are 1.669%/K(λ_(ex)=296 nm)and1.664%/K(λ_(ex)=396 nm),re spectively.It is interesting to note that different SRcan be obtained by varying the excitation wavelength to the CSNO:0.1 mol%Mn^(4+)/0.5 mol%Eu^(3+)phosphor.Ultimately,this work provides a reference for the development of highly sensitive fluorescent materials based on dualemitting centers of double-perovskite.展开更多
Inhibitory leukocyte immunoglobulin-like receptors(LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs(ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, ...Inhibitory leukocyte immunoglobulin-like receptors(LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs(ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, non-receptor type 6(PTPN6, SHP-1), protein tyrosine phosphatase, non-receptor type 6(PTPN6, SHP-2), or Src homology 2 domain containing inositol phosphatase(SHIP) to negatively regulate immune cell activation. These receptors are known to play important regulatory roles in immune and neuronal functions. Recent studies demonstrated that several of these receptors are expressed by cancer cells. Importantly, they may directly regulate development, drug resistance, and relapse of cancer, and the activity of cancer stem cells. Although counterintuitive, these findings are consistent with the generally immune-suppressive and thus tumor-promoting roles of the inhibitory receptors in the immune system. This review focuses on the ligands, expression pattern, signaling, and function of LILRB family in the context of cancer development. Because inhibition of the signaling of certain LILRBs directly blocks cancer growth and stimulates immunity that may suppress tumorigenesis, but does not disturb normal development, LILRB signaling pathways may represent ideal targets for treating hematological malignancies and perhaps other tumors.展开更多
基金Project supported by National Natural Science Foundation of China(12004062)Natural Science Foundation of Chongqing(CSTB2024NSCQLZX0030)+1 种基金the Science and Technology Research Program of Chongqing Municipal Education Commission(KJZD-M202300601,KJZD-K202300612,KJQN202300613)Venture and Innovation Support Program for Chongqing Overseas Returnees(CX2019085,CX2022024)。
文摘A novel series of Mn^(4+)and Eu^(3+)co-doped double-perovskite Ca_(2)ScNbO_(6)(CSNO)phosphor was synthesized in this work.The phase structure and photoluminescence properties were systematically researched.Due to the different thermal quenching properties of Mn^(4+)and Eu^(3+)ions,a dual-mode temperature measurement technique over a wide temperature range was established.The CSNO phosphor co-doped with Mn^(4+)and Eu^(3+)ions has a self-calibrated effect due to the different thermal quenching effects of Mn^(4+)and Eu^(3+)ions.The maximum relative sensitivity(S_(R1,R2))values of the CSNO:0.1 mol%Mn^(4+)/0.5 mol%Eu^(3+)phosphor are determined to be 1.92%/K and 1.76%/K at 523 K,under excitation at 296 and 396 nm,respectively.Additionally,the temperature-dependent lifetime of Mn^(4+)indicates that the maximum S_(R3,R4) values for the synthesized phosphors are 1.669%/K(λ_(ex)=296 nm)and1.664%/K(λ_(ex)=396 nm),re spectively.It is interesting to note that different SRcan be obtained by varying the excitation wavelength to the CSNO:0.1 mol%Mn^(4+)/0.5 mol%Eu^(3+)phosphor.Ultimately,this work provides a reference for the development of highly sensitive fluorescent materials based on dualemitting centers of double-perovskite.
基金supported b y the Na tional In stitu te o f Health(1R01CA172268)the Leukemia&Lymphoma Society(1024-14+7 种基金TRP-6024-14)the Robert A.Welch Foundation(I-1834)the Cancer Prevention and Research Institute of Texas(RP140402 and DP150056)the Innovation Program of Shanghai Municipal Education Commission(13G20)the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learningthe National Natural Science Foundation of China(813706548142200181471524)
文摘Inhibitory leukocyte immunoglobulin-like receptors(LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs(ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, non-receptor type 6(PTPN6, SHP-1), protein tyrosine phosphatase, non-receptor type 6(PTPN6, SHP-2), or Src homology 2 domain containing inositol phosphatase(SHIP) to negatively regulate immune cell activation. These receptors are known to play important regulatory roles in immune and neuronal functions. Recent studies demonstrated that several of these receptors are expressed by cancer cells. Importantly, they may directly regulate development, drug resistance, and relapse of cancer, and the activity of cancer stem cells. Although counterintuitive, these findings are consistent with the generally immune-suppressive and thus tumor-promoting roles of the inhibitory receptors in the immune system. This review focuses on the ligands, expression pattern, signaling, and function of LILRB family in the context of cancer development. Because inhibition of the signaling of certain LILRBs directly blocks cancer growth and stimulates immunity that may suppress tumorigenesis, but does not disturb normal development, LILRB signaling pathways may represent ideal targets for treating hematological malignancies and perhaps other tumors.
