Lin Shuran and her husband Fang Chuxiang are exceptional artists who are often mentioned together when talking about contemporary Lingnan art.Compared to her husband’s fame in the field of flower-andbird painting,Lin...Lin Shuran and her husband Fang Chuxiang are exceptional artists who are often mentioned together when talking about contemporary Lingnan art.Compared to her husband’s fame in the field of flower-andbird painting,Lin shows unique artistic sensitivity as a female inheritor of the Lingnan School and quietly preserves the cultural lineage of Lingnan painting.展开更多
BCL2-associated anthanogene 3 facilitates the clearance of tau protein aggregates:BCL2-associated anthanogene 3(BAG3)is a ubiquitously expressed and highly conserved multi-functional co-chaperone protein involved in m...BCL2-associated anthanogene 3 facilitates the clearance of tau protein aggregates:BCL2-associated anthanogene 3(BAG3)is a ubiquitously expressed and highly conserved multi-functional co-chaperone protein involved in many biological processes that supports cellular homeostasis,including the inhibition of apoptosis by preventing mitochondrial BAX localization(Lin et al.,2022)and the promotion of the degradation of hyperphosphorylated tau aggregates by its interactions with SQSTM1(p62)(Hamano and Mutoh,2022).展开更多
In A Critical Wm.Theodore de Bary,author Deng Lin provides an in-depth exploration of the life and work of the renowned scholar Wm.Theodore de Bary,whose contributions to the study of East Asian philosophy and his adv...In A Critical Wm.Theodore de Bary,author Deng Lin provides an in-depth exploration of the life and work of the renowned scholar Wm.Theodore de Bary,whose contributions to the study of East Asian philosophy and his advocacy for cross-cultural dialogue have made him an influential figure in the field of sinology.The book,published by Shandong Education Press in December 2013,is a comprehensive study that spans the historical,cultural,and intellectual contexts of de Bary’s scholarship,placing particular emphasis on his approach to Neo-Confucianism and his role in bridging Eastern and Western academic traditions.展开更多
Background:Intracerebral hemorrhage(ICH)remains a devastating neurological disorder with limited therapeutic options.Neural stem cell(NSC)-based therapies have emerged as a potential regenerative approach,yet the mole...Background:Intracerebral hemorrhage(ICH)remains a devastating neurological disorder with limited therapeutic options.Neural stem cell(NSC)-based therapies have emerged as a potential regenerative approach,yet the molecular mechanisms regulating NSC behavior require further elucidation.The role of miR-21 in NSC differentiation and proliferation during ICH recovery remains unexplored.Methods:In vitro NSC cultures were analyzed for miR-21 expression dynamics during differentiation via qPCR.Lentiviral overexpression and knockdown of miR-21 were employed to assess its functional impact.The SOX2/LIN28-let-7 pathway was investigated using Western blot,luciferase reporter assays,and immunofluorescence.In vivo,miR-21-overexpressing NSCs were transplanted into a murine ICH model,with neurogenesis evaluated by immunostaining and neurological recovery assessed through behavioral tests(mNSS,rotarod).Results:miR-21 expression significantly increased during NSC differentiation,correlating with reduced SOX2 levels.Mechanistically,miR-21 directly targeted SOX2,disrupting the SOX2/LIN28-let-7 axis to promote NSC proliferation and lineage commitment.In ICH mice,transplantation of miR-21-overexpressing NSCs enhanced neurogenesis and improved motor coordination and neurological deficits at 28 days post-transplantation.Conclusions:Our findings identify miR-21 as a critical regulator of NSC plasticity through SOX2/LIN28-let-7 signaling,highlighting its therapeutic potential for enhancing neuroregeneration and functional recovery in ICH.Targeting miR-21 may represent a novel strategy to optimize NSC-based therapies for hemorrhagic stroke.展开更多
文摘Lin Shuran and her husband Fang Chuxiang are exceptional artists who are often mentioned together when talking about contemporary Lingnan art.Compared to her husband’s fame in the field of flower-andbird painting,Lin shows unique artistic sensitivity as a female inheritor of the Lingnan School and quietly preserves the cultural lineage of Lingnan painting.
基金supported by the award W81XWH1910309 (to HF) from the Department of Defensethe award R01-AG075092-01 (to HF)+2 种基金the award RF1AG063521 from the National Institute of Aging at the National Institutes of Healththe Neurological Research Institute Seed grant (to HF) from The Ohio State Universitythe Summer Undergraduate Research Fellowship (to NS) from The Ohio State University Chronic Brain Injury Discovery Theme
文摘BCL2-associated anthanogene 3 facilitates the clearance of tau protein aggregates:BCL2-associated anthanogene 3(BAG3)is a ubiquitously expressed and highly conserved multi-functional co-chaperone protein involved in many biological processes that supports cellular homeostasis,including the inhibition of apoptosis by preventing mitochondrial BAX localization(Lin et al.,2022)and the promotion of the degradation of hyperphosphorylated tau aggregates by its interactions with SQSTM1(p62)(Hamano and Mutoh,2022).
文摘In A Critical Wm.Theodore de Bary,author Deng Lin provides an in-depth exploration of the life and work of the renowned scholar Wm.Theodore de Bary,whose contributions to the study of East Asian philosophy and his advocacy for cross-cultural dialogue have made him an influential figure in the field of sinology.The book,published by Shandong Education Press in December 2013,is a comprehensive study that spans the historical,cultural,and intellectual contexts of de Bary’s scholarship,placing particular emphasis on his approach to Neo-Confucianism and his role in bridging Eastern and Western academic traditions.
基金Shanghai Minhang District Health Commission Project,Grant/Award Number:2022MHZ062Shanghai Sixth People's Hospital,Grant/Award Number:ynhg202311 and ynms202411。
文摘Background:Intracerebral hemorrhage(ICH)remains a devastating neurological disorder with limited therapeutic options.Neural stem cell(NSC)-based therapies have emerged as a potential regenerative approach,yet the molecular mechanisms regulating NSC behavior require further elucidation.The role of miR-21 in NSC differentiation and proliferation during ICH recovery remains unexplored.Methods:In vitro NSC cultures were analyzed for miR-21 expression dynamics during differentiation via qPCR.Lentiviral overexpression and knockdown of miR-21 were employed to assess its functional impact.The SOX2/LIN28-let-7 pathway was investigated using Western blot,luciferase reporter assays,and immunofluorescence.In vivo,miR-21-overexpressing NSCs were transplanted into a murine ICH model,with neurogenesis evaluated by immunostaining and neurological recovery assessed through behavioral tests(mNSS,rotarod).Results:miR-21 expression significantly increased during NSC differentiation,correlating with reduced SOX2 levels.Mechanistically,miR-21 directly targeted SOX2,disrupting the SOX2/LIN28-let-7 axis to promote NSC proliferation and lineage commitment.In ICH mice,transplantation of miR-21-overexpressing NSCs enhanced neurogenesis and improved motor coordination and neurological deficits at 28 days post-transplantation.Conclusions:Our findings identify miR-21 as a critical regulator of NSC plasticity through SOX2/LIN28-let-7 signaling,highlighting its therapeutic potential for enhancing neuroregeneration and functional recovery in ICH.Targeting miR-21 may represent a novel strategy to optimize NSC-based therapies for hemorrhagic stroke.
