饮用水水源水质安全是关系公众健康的重大民生问题,科学、准确地反映水质检测状况对保障用水安全至关重要。实验室信息化管理系统(laboratory information management system,LIMS)的引入可实现水质检验的全流程管理与溯源,通过规范化...饮用水水源水质安全是关系公众健康的重大民生问题,科学、准确地反映水质检测状况对保障用水安全至关重要。实验室信息化管理系统(laboratory information management system,LIMS)的引入可实现水质检验的全流程管理与溯源,通过规范化的质量控制,显著提升检测结果的科学性与准确性。系统分析了传统水质检测中存在的质量管理问题,结合乌鲁木齐水质监测中心实践案例,从流程优化、数据管理、资源控制及追溯性等方面阐述其在全流程质量控制中的应用,通过对比数据验证了LIMS在提升效率、降低误差、强化质控合规性方面的成效,并提出技术与管理协同提升检测质量的路径。展开更多
LIM zinc finger domain containing 1(LIMS1),an evolutionarily conserved LIM domain adaptor protein,is implicated in diverse pathologies,including cancer and neurological disorders.However,its roles in cardiac diseases ...LIM zinc finger domain containing 1(LIMS1),an evolutionarily conserved LIM domain adaptor protein,is implicated in diverse pathologies,including cancer and neurological disorders.However,its roles in cardiac diseases and the underlying mechanisms remain unclear.Here,we explore the functions and mechanisms of LIMS1 in cardiac remodeling and heart failure.We identify the elevated LIMS1 expression in patients with dilated cardiomyopathy and murine cardiomyocytes,suggesting that LIMS1 dysregulation contributes to cardiac pathology.Using CRISPR/Cas9 technology,we generate a zebrafish model of lims1 loss-offunction mutant,which exhibits severe cardiac chamber remodeling,systolic dysfunction,and premature mortality,demonstrating the essential role of lims1 in maintaining cardiac integrity.Transcriptomic profiling reveals the activation of the gp130/Jak1/Stat3 signaling in the lims1-deficient hearts.Strikingly,pharmacological inhibition of Stat3 or c-Fos partially rescues cardiomyopathy phenotypes.Our findings reveal the underlying mechanism of lims1 deficiency-caused heart failure through gp130/Jak1/Stat3 hyperactivation,offering insights into cardiac remodeling and potential therapeutic strategies.展开更多
随着环境检测行业竞争的白热化和市场监管要求的不断提升,第三方环境检测实验室信息管理系统(LIMS)已成为行业数字化转型的核心工具。本文从LIMS的各项功能出发,梳理其在我国的发展历程,分析当前LIMS系统前期投入高和第三方环境检测信...随着环境检测行业竞争的白热化和市场监管要求的不断提升,第三方环境检测实验室信息管理系统(LIMS)已成为行业数字化转型的核心工具。本文从LIMS的各项功能出发,梳理其在我国的发展历程,分析当前LIMS系统前期投入高和第三方环境检测信息化资金投入少、实验室人员能力参差不齐等问题,并提出企业需增强预见性、提前布局,开发商提高环境专业水平,政府政策辅助等多方解决对策。未来LIMS可以通过与AI大模型技术融合,推动环境检测行业实现“智慧决策”,为环境治理体系现代化提供支撑。With the intensification of competition in the environmental testing industry and continuous upgrades in market regulatory requirements, third-party environmental testing laboratories’ Laboratory Information Management Systems (LIMS) have become a core tool for digital transformation in the sector. This article analyzes the development history of LIMS in China, starting from its functional capabilities, and examines current challenges such as high upfront investment in LIMS systems, insufficient funding for information technology in testing institutions, and inconsistent personnel expertise across laboratories. It proposes multi-party solutions including enterprises enhancing foresight and proactive planning, developers improving environmental domain expertise, and government policy support. In the future, LIMS could integrate with large AI models to drive “smart decision-making” in environmental testing, thereby supporting the modernization of environmental governance systems.展开更多
文摘饮用水水源水质安全是关系公众健康的重大民生问题,科学、准确地反映水质检测状况对保障用水安全至关重要。实验室信息化管理系统(laboratory information management system,LIMS)的引入可实现水质检验的全流程管理与溯源,通过规范化的质量控制,显著提升检测结果的科学性与准确性。系统分析了传统水质检测中存在的质量管理问题,结合乌鲁木齐水质监测中心实践案例,从流程优化、数据管理、资源控制及追溯性等方面阐述其在全流程质量控制中的应用,通过对比数据验证了LIMS在提升效率、降低误差、强化质控合规性方面的成效,并提出技术与管理协同提升检测质量的路径。
基金the National Natural Science Foundation of China(82070394,82371863,31970504,82100491,and 82000307)the Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control project(HPKL2023001)for their support of this research.
文摘LIM zinc finger domain containing 1(LIMS1),an evolutionarily conserved LIM domain adaptor protein,is implicated in diverse pathologies,including cancer and neurological disorders.However,its roles in cardiac diseases and the underlying mechanisms remain unclear.Here,we explore the functions and mechanisms of LIMS1 in cardiac remodeling and heart failure.We identify the elevated LIMS1 expression in patients with dilated cardiomyopathy and murine cardiomyocytes,suggesting that LIMS1 dysregulation contributes to cardiac pathology.Using CRISPR/Cas9 technology,we generate a zebrafish model of lims1 loss-offunction mutant,which exhibits severe cardiac chamber remodeling,systolic dysfunction,and premature mortality,demonstrating the essential role of lims1 in maintaining cardiac integrity.Transcriptomic profiling reveals the activation of the gp130/Jak1/Stat3 signaling in the lims1-deficient hearts.Strikingly,pharmacological inhibition of Stat3 or c-Fos partially rescues cardiomyopathy phenotypes.Our findings reveal the underlying mechanism of lims1 deficiency-caused heart failure through gp130/Jak1/Stat3 hyperactivation,offering insights into cardiac remodeling and potential therapeutic strategies.
文摘随着环境检测行业竞争的白热化和市场监管要求的不断提升,第三方环境检测实验室信息管理系统(LIMS)已成为行业数字化转型的核心工具。本文从LIMS的各项功能出发,梳理其在我国的发展历程,分析当前LIMS系统前期投入高和第三方环境检测信息化资金投入少、实验室人员能力参差不齐等问题,并提出企业需增强预见性、提前布局,开发商提高环境专业水平,政府政策辅助等多方解决对策。未来LIMS可以通过与AI大模型技术融合,推动环境检测行业实现“智慧决策”,为环境治理体系现代化提供支撑。With the intensification of competition in the environmental testing industry and continuous upgrades in market regulatory requirements, third-party environmental testing laboratories’ Laboratory Information Management Systems (LIMS) have become a core tool for digital transformation in the sector. This article analyzes the development history of LIMS in China, starting from its functional capabilities, and examines current challenges such as high upfront investment in LIMS systems, insufficient funding for information technology in testing institutions, and inconsistent personnel expertise across laboratories. It proposes multi-party solutions including enterprises enhancing foresight and proactive planning, developers improving environmental domain expertise, and government policy support. In the future, LIMS could integrate with large AI models to drive “smart decision-making” in environmental testing, thereby supporting the modernization of environmental governance systems.
