The age at which a woman enters natural menopause has also been associated to death from any cause.Menopause is a natural component of aging that happens between the ages of 45 and 55,with the average menopausal age b...The age at which a woman enters natural menopause has also been associated to death from any cause.Menopause is a natural component of aging that happens between the ages of 45 and 55,with the average menopausal age being 51.Previous research has revealed the age at which women reach menopause,but there is no evidence to support the link between menopause and longevity.We made a study in assessing the limits of maximum lifespan at menopausal age in our previous article.In this paper,we aim to predict the maximum lifespan of women at mean menopausal age.展开更多
This study aimed to investigate the anti-aging effects of black rice-anthocyanin(BRA)in Drosophila melanogaster and HUVEC cells.In this study,the strong antioxidant activity of BRA in HUVEC cells,D.melanogaster of lif...This study aimed to investigate the anti-aging effects of black rice-anthocyanin(BRA)in Drosophila melanogaster and HUVEC cells.In this study,the strong antioxidant activity of BRA in HUVEC cells,D.melanogaster of lifespan extension,and molecular mechanism were elucidated.Firstly,the BRA increased enzyme activities of superoxide dismutase(SOD)and catalase(CAT),as well as the expression of phosphatidyl inositol 3-kinase(PI3K)/protein kinase B(Akt)protein while decreasing the accumulation of reactive oxygen species(ROS)and malondialdehyde(MDA)in both H_(2)O_(2)-induced HUVEC cells and D.melanogaster.Secondly,the BRA extended the lifespan of D.melanogaster by improving crawling ability and intestine abilities in the microbial environment,barrier function,and number of autophagic lysosomes,as well as inhibiting the abnormal multiplication of stem cells in the intestine.Thirdly,the BRA downregulated expression levels of Akt-1 and mTOR in D.melanogaster while upregulated downstream autophagy gene expression levels of Atg1,Atg5,Atg8a,and Atg8b,as well as the expression levels of SOD,CAT,and 4E-binding protein.Lastly,the anti-aging mechanism was also verified by both the computerized molecular simulation and network pharmacology.Thus,the prolonged lifespan of D.melanogaster by blocking the mTOR pathway and activating autophagy,which could be further used for improving health and prolonging life.展开更多
Li plating behavior of the Li metal anode and its compatibility with electrolytes play a decisive role in the electrochemical performance of the Li metal batteries(LMBs),while the intrinsic highly reactive Li would in...Li plating behavior of the Li metal anode and its compatibility with electrolytes play a decisive role in the electrochemical performance of the Li metal batteries(LMBs),while the intrinsic highly reactive Li would induce serious results especially under deep Li plating/stripping depth and with lean electrolytes.Herein,we propose an innovative strategy to simultaneously regulate the bulk construction and the preferential orientation of Li deposition by introducing Li22Sn5/Li-Mg alloys to realize ultra-stable thin Li anodes with long lifespan.The alloys can form a continuous framework with high lithiophilicity and fast ion-diffusion to enable homogenous Li flux,and meanwhile tune the preferential orientation of Li from the conventional(110)plane to(200)to lower the Li reactivity with electrolytes and optimize Li deposition.Therefore,the thin Li-Sn-Mg alloy anode showcases ultra-stable cycling without volume changes and dendrites under a deep Li plating/stripping depth of 89.1%(5 mAh cm^(-2))for over 1200 h in commercial carbonate electrolytes.Moreover,a multilayered NCM811pouch cell with a high energy density of403.6 Wh kg^(-1)is achieved under the harsh conditions of low N/P ratio(0.769)and lean electrolytes(~2.1 g Ah^(-1)).Synchronously,the thin alloy anode shows improved air stability which benefits the manufacturing process and performance of LMBs,displaying the great application potential of these alloy anodes.展开更多
Sparse felsic microgranitoid enclaves(FMEs)in the Shangshuiquan granite of the Zhangjiakou district,the north margin of the North China Craton,are fine-grained,dark-colored and exhibit subangular to subspherical shape...Sparse felsic microgranitoid enclaves(FMEs)in the Shangshuiquan granite of the Zhangjiakou district,the north margin of the North China Craton,are fine-grained,dark-colored and exhibit subangular to subspherical shapes.They share similar mineral assemblages,chemical compositions,and zircon Hf isotope compositions to the host granite.New zircon U-Pb geochronology reveals that the FMEs crystallized at 156-153 Ma,while the Shangshuiquan granite formed at ca.146 Ma.The FEMs are,therefore,10 to 7 Ma older than the host granite.Combined with petrological evidence,we suggest that the FMEs are fragments of rapidly crystalized magmas,which were captured by the younger Shangshuiquan magma.Magmas of the FMEs and Shangshuiquan granite originated from the same reservoir.The Shangshuiquan granite is the result of small batches of magma being built up incrementally,and the FMEs belong to the earlier batches of magma.The lifespan of the Shangshuiquan magma reservoir exceeds 10 Ma.FMEs derived from cogenetic fragments have the potential to offer critical information about the formation process and timescale of granitic plutons.展开更多
Understanding the drivers of variations in fine root lifespan is key to informing nutrient cycling and productivity in terrestrial ecosystems.However,the general patterns and determinants of forest fine root lifespan ...Understanding the drivers of variations in fine root lifespan is key to informing nutrient cycling and productivity in terrestrial ecosystems.However,the general patterns and determinants of forest fine root lifespan at the global scale are still limited.We compiled a dataset of 421 fine root lifespan observations from 76 tree species globally to assess phylogenetic signals among species,explored relationships between fine root lifespan and biotic and abiotic factors,and quantified the relative importance of phylogeny,root system structure and functions,climatic and edaphic factors in driving global fine root lifespan variations.Overall,fine root lifespan showed a clear phylogenetic signal,with gymnosperms having a longer fine root lifespan than angiosperms.Fine root lifespan was longer for evergreens than deciduous trees.Ectomycorrhizal(ECM)plants had an extended fine root lifespan than arbuscular mycorrhizal(AM)plants.Among different climatic zones,fine root lifespan was the longest in the boreal zone,while it did not vary between the temperate and tropical zone.Fine root lifespan increased with soil depth and root order.Furthermore,the analysis of relative importance indicated that phylogeny was the strongest driver influencing the variation in forest fine root lifespan,followed by soil clay content,root order,mean annual temperature,and soil depth,while other environmental factors and root traits exerted weaker effects.Our results suggest that the global pattern of fine root lifespan in forests is shaped by the interplay of phylogeny,root traits and environmental factors.These findings necessitate accurate representations of tree evolutionary history in earth system models to predict fine root longevity and its responses to global changes.展开更多
The high specific capacity and low negative electrochemical potential of lithium metal anodes(LMAs),may allow the energy density threshold of Li metal batteries(LMBs)to be pushed higher.However,the existing detrimenta...The high specific capacity and low negative electrochemical potential of lithium metal anodes(LMAs),may allow the energy density threshold of Li metal batteries(LMBs)to be pushed higher.However,the existing detrimental issues,such as dendritic growth and volume expansion,have hindered the practical implementation of LMBs.Introducing three-dimensional frameworks(e.g.,copper and nickel foam),have been regarded as one of the fundamental strategies to reduce the local current density,aiming to extend the Sand'time.Nevertheless,the local environment far from the skeleton is almost the same as the typical plane Li,due to macroporous space of metal foam.Herein,we built a double-layered 3D current collector of Li alloy anchored on the metal foam,with micropores interconnected macropores,via a viable thermal infiltration and cooling strategy.Due to the excellent electronic and ionic conductivity coupled with favorable lithiophilicity,the Li alloy can effectively reduce the nucleation barrier and enhance the Li^(+)transportation rate,while the metal foam can role as the primary promotor to enlarge the surface area and buffer the dimensional variation.Synergistically,the Li composite anode with hierarchical structure of primary and secondary scaffolds realized the even deposition behavior and minimum volume expansion,outputting preeminent prolonged cycling performances under high rate.展开更多
The organ-specific toxicity resulting from microplastic(MP)exposure has been extensively explored,particularly concerning the gut,liver,testis,and lung.However,under natural conditions,these effects are not restricted...The organ-specific toxicity resulting from microplastic(MP)exposure has been extensively explored,particularly concerning the gut,liver,testis,and lung.However,under natural conditions,these effects are not restricted to specific organs or tissues.Investigating whether MP exposure presents a systemic threat to an entire organism,impacting factors such as lifespan,sleep,and fecundity,is essential.In this study,we investigated the effects of dietary exposure to two different doses of MPs(1–5μm)using the terrestrial model organism Drosophila melanogaster.Results indicated that the particles caused gut damage and remained within the digestive system.Continuous MP exposure significantly shortened the lifespan of adult flies.Even short-term exposure disrupted sleep patterns,increasing the length of daytime sleep episodes.Additionally,one week of MP exposure reduced ovary size,with a trend towards decreased egg-laying in mated females.Although MPs did not penetrate the brain or ovaries,transcriptome analysis revealed altered gene expression in these tissues.In the ovary,Gene Ontology(GO)analysis indicated genotoxic effects impacting inflammation,circadian regulation,and metabolic processes,with significant impacts on extracellular structure-related pathways.In the brain,GO analysis identified changes in pathways associated with proteolysis and carbohydrate metabolism.Overall,this study provides compelling evidence of the systemic negative effects of MP exposure,highlighting the urgent need to address and mitigate environmental MP pollution.展开更多
Enhancing forest cover is important for effective climate change mitigation.Studies suggest that drylands are promising areas for expanding forests,but conflicts arise with increased forest area and water consumption....Enhancing forest cover is important for effective climate change mitigation.Studies suggest that drylands are promising areas for expanding forests,but conflicts arise with increased forest area and water consumption.Recent tree mortality in drylands raises concerns about carbon sequestration potential in tree plantations.Using Chinese dryland tree plantations as an example,we compared their growth with natural forests.Our results suggested plantation trees grew 1.6–2.1 times faster in juvenile phases,significantly shortening time to maturity(13.5 vs.30 years)compared to natural forests,potentially stemming from simple plantation age structures.Different from natural forests,74%of trees in plantations faced growth decline,indicating a short“prime period”for carbon sequestration and even a short lifespan.Additionally,a negative relationship between evapotranspiration and tree growth was observed in tree plantations since maturity,leading to high sensitivities of trees to vapor pressure deficit and soil water.However,this was not observed in natural forests.To address this,we suggest afforestation in drylands should consider complex age structures,ensuring a longer prime period for carbon sequestration and life expectancy in tree plantations.展开更多
Constructing heterostructure is considered as an effective strategy to address the sluggish electronic and ionic kinetics of anode materials for sodium ion batteries(SIBs).However,realizing the orientated growth and u...Constructing heterostructure is considered as an effective strategy to address the sluggish electronic and ionic kinetics of anode materials for sodium ion batteries(SIBs).However,realizing the orientated growth and uniform distribution of the heterostructure is still a great challenge.Herein,the regulated novel CoSe_(2)/NiSe_(2)heterostructure confined in N-doped carbon nanofibers(CoSe_(2)/NiSe_(2)@N-C)are prepared by using Co/Ni-ZIF template,in which,the CoSe_(2)/NiSe_(2)heterostructures realize uniform distribution on a micro level.Benefiting from the unique heterostructure and N-doped carbon nanofibers,the CoSe_(2)/NiSe_(2)@N-C deliveries superior rate capability and durable cycle lifespan with a reversible capacity of 400.5 mA h g^(-1)after 5000 cycles at 2 A g^(-1).The Na-ion full battery with CoSe_(2)/NiSe_(2)@N-C anode and layered oxide cathode displays a remarkable energy density of 563 W h kg^(-1)with 241.1 W kg^(-1)at 0.1 A g^(-1).The theoretical calculations disclose that the periodic and directional built-in electric-field along with the heterointerfaces of CoSe_(2)/NiSe_(2)@N-C can accelerate electrochemical reaction kinetics.The in(ex)situ experimental measurements reveal the reversible conversion reaction and stable structure of CoSe_(2)/NiSe_(2)@N-C during Na+insertion/extraction.The study highlights the potential ability of precisely controlled heterostructure to stimulate the electrochemical performances of advanced anode for SIBs.展开更多
The progress of zinc(Zn)metal batteries(ZMBs)is greatly limited by poor cycling stability because of the mutual restrictions of dendrite growth,corrosion reactions,and passivation.In this work,an ultralong lifespan(~7...The progress of zinc(Zn)metal batteries(ZMBs)is greatly limited by poor cycling stability because of the mutual restrictions of dendrite growth,corrosion reactions,and passivation.In this work,an ultralong lifespan(~7800 h),dendrite-free Zn metal anode is enabled via fabricating a functional hydrogel electrolyte out of polyacrylamide/graphene oxide(GO)/agarose(PGA)with a multifully cross-linked network.The synergetic integration of GO nanosheets and double-network structure endows the PGA hydrogel electrolyte with high ionic conductivity and excellent mechanical performance.More importantly,the abundant hydrophilic groups and stable three-dimensional cross-linked network of PGA electrolyte effectively constrain Zn^(2+)diffusion laterally along the Zn surface,which simultaneously prohibits waterinduced corrosion and thus significantly enhances Zn anode reversibility.Both theoretical simulations and experiments reveal that the PGA electrolyte is capable of optimizing de-solvation kinetics and harmonizing Zn^(2+)flux at the electrolyte-electrode interface,ensuring uniform Zn^(2+)deposition.Consequently,an ultra-long lifespan of 7800 h is achieved in the symmetric cell with the PGA electrolyte.Even at a high Zn utilization of 42.7%,it still delivers stable cycling over 1100 h.This work provides a practical and beneficial approach to dramatically extending the lifespan of the Zn anode and thus achieving high-performance ZMBs.展开更多
We used toxicity identification evaluation （TIE） method to confirm the combinational effects of identified toxic metals in a paper recycling mill effluent in inducing the decreased lifespan in nematode Caenorhabditi...We used toxicity identification evaluation （TIE） method to confirm the combinational effects of identified toxic metals in a paper recycling mill effluent in inducing the decreased lifespan in nematode Caenorhabditis elegans.Exposure to Ca ＋ Al caused more severely decreased lifespan than that exposed to Ca,or Al;and exposure to Ca ＋ Fe induced more severely decreased lifespan than that exposed to Ca,or Fe.Exposure to Ca＋Al＋Fe caused more severely decreased lifespan than that exposed to Ca,or Ca＋Fe.Moreover,the baseline toxicity on lifespan was doubled by doubling the concentration of combined metals （Ca＋Al＋Fe） in spiking test in original effluent （oe）,and lifespan defects in oe＋Ca＋Al＋Fe exposed nematodes were more severe than that in Ca＋Al＋Fe exposed nematode.Therefore,Ca＋Al＋Fe exposure may largely explain the formation of decreased lifespan induced by the examined industrial effluent.Furthermore,the observed reduction of lifespan induced by the combination of high level of Ca with other metals may be at least partially independent of the insulin-like pathway.展开更多
CoQ is an essential electron cartier in the mitochondrial respiratory chain of both eukaryotes and prokaryotes. It consists of a benzoquinone head group and a hydrophobic polyisoprenoid tail. The genes （COQ1-9） invo...CoQ is an essential electron cartier in the mitochondrial respiratory chain of both eukaryotes and prokaryotes. It consists of a benzoquinone head group and a hydrophobic polyisoprenoid tail. The genes （COQ1-9） involved in CoQ biosynthesis have been characterized in yeast. In this study, we generated and molecularly characterized a mutant allele of a novel Drosophila gene, sbo, which encodes a protein that is predicted to catalyze the prenylation of p-hydroxybenzoate with the isoprenoid chain during the process of CoQ synthesis. Expression of sbo in yeast rescues the lethality of ACOQ2 mutant cells, indicating that sbo is a functional homolog of COQ2. HPLC results show that the levels of CoQ9 and COQlo were significantly reduced in sbo heterozygous adult flies. Furthermore, the mean lifespans of males and females heterozygous for sbo are extended by 12.5% and 30.8%, respectively. Homozygous sbo animals exhibit reduced activities of the insulin/insulin-like growth factor signaling （IIS） pathway. Taken together, we conclude that sbo is an essential gene for Drosophila development, mutation of which leads to an extension of lifespan most likely by altering endogenous CoQ biosynthesis.展开更多
A number of research has shown that the plant polyphenol resveratrol,one of the most prominent small molecules,has beneficial protective effects in multiple organisms,including worms,flies,and killifish.To understand ...A number of research has shown that the plant polyphenol resveratrol,one of the most prominent small molecules,has beneficial protective effects in multiple organisms,including worms,flies,and killifish.To understand the effects of resveratrol on lifespan,we evaluated its effects in the silkworm Bombyx mori.In this study,we found that lifespan was significantly prolonged in both female and male silkworms treated with resveratrol.Silkworm larval weight was significantly increased from day 3 of the 5th larval instar(L5D3)to day 7 of the 5th larval instar(L5D7).However,the weight of the pupa,cocoon,and total cocoon was not significantly different in female silkworms with resveratrol treatment than that in controls.Meanwhile,resveratrol significantly improved the thermotolerance of the silkworms,which enhanced their survival rate.Moreover,antioxidant activity was increased by resveratrol in both female and male silkworms.Furthermore,an antioxidant-related signalling pathway,SIRT7-FoxO-GST,was activated in silkworms with resveratrol treatment.Collectively,these results help us to understand the molecular pathways underlying resveratrol induced pro-longevity effects and indicate that silkworm is a promising animal model for evaluating the effects of lifespan-extending drugs.展开更多
Seismic hazard levels lower than those for design of new buildings have been permitted for seismic evaluation and retrofi t of existing buildings due to the relatively short remaining lifespans. The seismic hazard red...Seismic hazard levels lower than those for design of new buildings have been permitted for seismic evaluation and retrofi t of existing buildings due to the relatively short remaining lifespans. The seismic hazard reduction enables costeff ective seismic evaluation and retrofi t of existing buildings with limited structural capacity. The current study proposes seismic hazard reduction factors for Korea, one of low to moderate seismicity regions. The seismic hazard reduction factors are based on equal probabilities of non-exceedance within diff erent remaining building lifespans. A validation procedure is proposed to investigate equality of seismic risk in terms of ductility-based limit states using seismic fragility assessment of nonlinear SDOF systems, of which retrofi t demands are determined by the displacement coeffi cient method of ASCE 41-13 for diff erent target remaining building lifespans and corresponding reduced design earthquakes. Validation result shows that the use of seismic hazard reduction factors can be permitted in conjunction with appropriate lower bounds of the remaining building lifespans.展开更多
As an irreplaceable dietary constituent,lipids play a vital important role in health,but their effects on aging process and longevity are still not well known yet.In this paper,the metabolic profiling and gene express...As an irreplaceable dietary constituent,lipids play a vital important role in health,but their effects on aging process and longevity are still not well known yet.In this paper,the metabolic profiling and gene expression levels of Caenorhabditis elegans were investigated to explore the effects of different edible oils on senescence and lifespan.The results showed that teaseed oil(TO)could prolong the life expectancy and slow down the aging process of C.elegans.Compared to the control group,the intake of lard oil(LO)and TO increased the expression levels of genes related to inhibition of protein aggregation(akt-1,daf-16,hsf-1,hsp-16.2)and lipid metabolism(daf-7,daf-1,mdt-15,lipl-4,fat-5,fat-6,fat-7),with a more significant alteration in TO group.Metabolomics revealed that palm oil can upregulated plenty of fatty acids(palmitic acid,stearic acid,tetracosanoic acid),together with some amino acids(tryptophan,L-aspartate,L-valine)and carbohydrate(D-glucose),while the trend was opposite in TO group.Besides,moderate-to-strong correlations were found between differential metabolites and changed genes.In general,this paper claimed that TO could prolong lifespan and slow down aging process via regulating the lipids,amino acids and carbohydrates metabolism.展开更多
Recent discoveries show steady improvements in life expectancy during modern decades. Does this support that humans continue to live longer in future? We recently put forward the maximum survival tendency, as found in...Recent discoveries show steady improvements in life expectancy during modern decades. Does this support that humans continue to live longer in future? We recently put forward the maximum survival tendency, as found in survival curves of industrialized countries, which is described by extended Weibull model with agedependent stretched exponent. The maximum survival ten dency suggests that human survival dynamics may possess its intrinsic limit, beyond which survival is inevitably forbidden. Based on such tendency, we develop the model and explore the patterns in the maximum lifespan limits from industrialized countries during recent three decades. This analysis strategy is simple and useful to interpret the complicated human survival dynamics.展开更多
Currently, the electrical system in Argentina is working at its maximum capacity, decreasing the margin between the installed power and demanded consumption, and drastically reducing the service life of transformer su...Currently, the electrical system in Argentina is working at its maximum capacity, decreasing the margin between the installed power and demanded consumption, and drastically reducing the service life of transformer substations due to overload (since the margin for summer peaks is small). The advent of the Smart Grids allows electricity distribution companies to apply data analysis techniques to manage resources more efficiently at different levels (avoiding damages, better contingency management, maintenance planning, etc.). The Smart Grids in Argentina progresses slowly due to the high costs involved. In this context, the estimation of the lifespan reduction of distribution transformers is a key tool to efficiently manage human and material resources, maximizing the lifetime of this equipment. Despite the current state of the smart grids, the electricity distribution companies can implement it using the available data. Thermal models provide guidelines for lifespan estimation, but the adjustment to particular conditions, brands, or material quality is done by adjusting parameters. In this work we propose a method to adjust the parameters of a thermal model using Genetic Algorithms, comparing the estimation values of top-oil temperature with measurements from 315 kVA distribution transformers, located in the province of Tucumán, Argentina. The results show that, despite limited data availability, the adjusted model is suitable to implement a transformer monitoring system.展开更多
The authors consider the Cauchy problem for the following nonlinear wave equationswhere x ∈ R3, t ≥ 0, ε > 0 is a small parameter, and obtain the sharp bounds for the lifespan of solution to (0.1). Specially, it...The authors consider the Cauchy problem for the following nonlinear wave equationswhere x ∈ R3, t ≥ 0, ε > 0 is a small parameter, and obtain the sharp bounds for the lifespan of solution to (0.1). Specially, it is proved that there exist two constants C1 and C2, which are independent of ε, then the lifespan T(ε) satisfies the folowing inequalities展开更多
The effects of degraded porphyran (P1) and natural porphyran (P) on the lifespan and vitality of Drosophila melanogaster are studied. The porphyrans, added daily to the food medium at 0.2% and 1% concentrations, can s...The effects of degraded porphyran (P1) and natural porphyran (P) on the lifespan and vitality of Drosophila melanogaster are studied. The porphyrans, added daily to the food medium at 0.2% and 1% concentrations, can significantly increase the lifespan in average of 55.79 and 58.23 d in 0.2% P1 diet females and 1% P1 diet males, extending by 12.29% and 8.60% over the corresponding controls, respectively. The effects of porphyrans on D. melanogaster in heat-stress condition were also examined, and found a remarkable increase in survival time. The results which are consistently associated with the use of porphyrans are related to their free radical scavenger action. Considerable increase in vitality demonstrated that vitalities of middle-aged fly (assessed by measuring their mating capacity) was observed after porphyrans addition. Therefore, porphyrans are effective in reducing the rate of aging, and P1 in low molecular weight is better than natural P.展开更多
Aim β-guanadinopropionic acid （β-6PA）, a creatine analog has been demonstrated to lead to thechronic activation of AMPK with increasing mitochondrial biogenesis. However, little is known about the effect of β-GPA...Aim β-guanadinopropionic acid （β-6PA）, a creatine analog has been demonstrated to lead to thechronic activation of AMPK with increasing mitochondrial biogenesis. However, little is known about the effect of β-GPA on lifespan extension. In current study, we explore whether β-GPA produces the lifespan extension in adult Drosophila and underlying mechanism. Methods The flies were fed in a normal chow diet containing different concentrations （300 raM,900 mM,2700 mM）of β-GPA. Western blot was also used to investigate protein expres- sions. RNA interference was employed to examine effects of lifespan in Drosophila by 13-GPA. Results 900 mM and 2700 mM β-GPA significant extended the lifespan and activated AMPK both in male and female Drosophila with elevated level of autophagy. We found that Atg8 was significantly upregulated and P62 was significantly down- regulated by 900 mM 13-GPA, on the other hand, when the expression of Atg5 protein, an essential protein for au- tophagy, was reduced by RNAi, the effect of β-GPA on lifespan extension was abolished. Inhibition of AMPK by either AMPK-RNAi or compound （2, significantly attenuated the expression of autophagy-related proteins and lifes- pan extension in Drosophila. We found that the activation of AMPK induced by β-GPA inhibited mTORC1 activity, implicating that mTORC1 may not prevent the activation of ULK1/Atgl by AMPK. Conclusion β-GPA can ex- tend the lifespan of Drosophila and this effect is mediated by AMPK-Atgl dependent autophagy.展开更多
文摘The age at which a woman enters natural menopause has also been associated to death from any cause.Menopause is a natural component of aging that happens between the ages of 45 and 55,with the average menopausal age being 51.Previous research has revealed the age at which women reach menopause,but there is no evidence to support the link between menopause and longevity.We made a study in assessing the limits of maximum lifespan at menopausal age in our previous article.In this paper,we aim to predict the maximum lifespan of women at mean menopausal age.
基金supported by the Shandong Provincial Natural Science Foundation,China(ZR2023QC145).
文摘This study aimed to investigate the anti-aging effects of black rice-anthocyanin(BRA)in Drosophila melanogaster and HUVEC cells.In this study,the strong antioxidant activity of BRA in HUVEC cells,D.melanogaster of lifespan extension,and molecular mechanism were elucidated.Firstly,the BRA increased enzyme activities of superoxide dismutase(SOD)and catalase(CAT),as well as the expression of phosphatidyl inositol 3-kinase(PI3K)/protein kinase B(Akt)protein while decreasing the accumulation of reactive oxygen species(ROS)and malondialdehyde(MDA)in both H_(2)O_(2)-induced HUVEC cells and D.melanogaster.Secondly,the BRA extended the lifespan of D.melanogaster by improving crawling ability and intestine abilities in the microbial environment,barrier function,and number of autophagic lysosomes,as well as inhibiting the abnormal multiplication of stem cells in the intestine.Thirdly,the BRA downregulated expression levels of Akt-1 and mTOR in D.melanogaster while upregulated downstream autophagy gene expression levels of Atg1,Atg5,Atg8a,and Atg8b,as well as the expression levels of SOD,CAT,and 4E-binding protein.Lastly,the anti-aging mechanism was also verified by both the computerized molecular simulation and network pharmacology.Thus,the prolonged lifespan of D.melanogaster by blocking the mTOR pathway and activating autophagy,which could be further used for improving health and prolonging life.
基金supported by the Jilin Province Science and Technology Department Major Science and Technology project[grant numbers 20220301004GX,20220301005GX]Key Subject Construction of Physical Chemistry of Northeast Normal Universitythe Fundamental Research Funds for the Central Universities[grant number 2412023QD014]。
文摘Li plating behavior of the Li metal anode and its compatibility with electrolytes play a decisive role in the electrochemical performance of the Li metal batteries(LMBs),while the intrinsic highly reactive Li would induce serious results especially under deep Li plating/stripping depth and with lean electrolytes.Herein,we propose an innovative strategy to simultaneously regulate the bulk construction and the preferential orientation of Li deposition by introducing Li22Sn5/Li-Mg alloys to realize ultra-stable thin Li anodes with long lifespan.The alloys can form a continuous framework with high lithiophilicity and fast ion-diffusion to enable homogenous Li flux,and meanwhile tune the preferential orientation of Li from the conventional(110)plane to(200)to lower the Li reactivity with electrolytes and optimize Li deposition.Therefore,the thin Li-Sn-Mg alloy anode showcases ultra-stable cycling without volume changes and dendrites under a deep Li plating/stripping depth of 89.1%(5 mAh cm^(-2))for over 1200 h in commercial carbonate electrolytes.Moreover,a multilayered NCM811pouch cell with a high energy density of403.6 Wh kg^(-1)is achieved under the harsh conditions of low N/P ratio(0.769)and lean electrolytes(~2.1 g Ah^(-1)).Synchronously,the thin alloy anode shows improved air stability which benefits the manufacturing process and performance of LMBs,displaying the great application potential of these alloy anodes.
基金funded by the National Natural Science Foundation of China (Grant Nos. 42373072, 42003032)the Open Project of Weihai Key Laboratory of Energy and Mineral Resources Investigation and Evaluation (Grant No. LDKF-2023WH-05)the China Geological Survey Project (Grant Nos. DD20190166, DD20190570 and DD20190159)
文摘Sparse felsic microgranitoid enclaves(FMEs)in the Shangshuiquan granite of the Zhangjiakou district,the north margin of the North China Craton,are fine-grained,dark-colored and exhibit subangular to subspherical shapes.They share similar mineral assemblages,chemical compositions,and zircon Hf isotope compositions to the host granite.New zircon U-Pb geochronology reveals that the FMEs crystallized at 156-153 Ma,while the Shangshuiquan granite formed at ca.146 Ma.The FEMs are,therefore,10 to 7 Ma older than the host granite.Combined with petrological evidence,we suggest that the FMEs are fragments of rapidly crystalized magmas,which were captured by the younger Shangshuiquan magma.Magmas of the FMEs and Shangshuiquan granite originated from the same reservoir.The Shangshuiquan granite is the result of small batches of magma being built up incrementally,and the FMEs belong to the earlier batches of magma.The lifespan of the Shangshuiquan magma reservoir exceeds 10 Ma.FMEs derived from cogenetic fragments have the potential to offer critical information about the formation process and timescale of granitic plutons.
基金provided by the National Key R&D Program of China(2023YFD2200904)the Scientific Research Project of Anhui Province(2022AH050873)+1 种基金the State Key Laboratory of Subtropical Silviculture(SKLSS-KF2023-08)the Anhui Provincial Science and Technology Special Project(202204c06020014)。
文摘Understanding the drivers of variations in fine root lifespan is key to informing nutrient cycling and productivity in terrestrial ecosystems.However,the general patterns and determinants of forest fine root lifespan at the global scale are still limited.We compiled a dataset of 421 fine root lifespan observations from 76 tree species globally to assess phylogenetic signals among species,explored relationships between fine root lifespan and biotic and abiotic factors,and quantified the relative importance of phylogeny,root system structure and functions,climatic and edaphic factors in driving global fine root lifespan variations.Overall,fine root lifespan showed a clear phylogenetic signal,with gymnosperms having a longer fine root lifespan than angiosperms.Fine root lifespan was longer for evergreens than deciduous trees.Ectomycorrhizal(ECM)plants had an extended fine root lifespan than arbuscular mycorrhizal(AM)plants.Among different climatic zones,fine root lifespan was the longest in the boreal zone,while it did not vary between the temperate and tropical zone.Fine root lifespan increased with soil depth and root order.Furthermore,the analysis of relative importance indicated that phylogeny was the strongest driver influencing the variation in forest fine root lifespan,followed by soil clay content,root order,mean annual temperature,and soil depth,while other environmental factors and root traits exerted weaker effects.Our results suggest that the global pattern of fine root lifespan in forests is shaped by the interplay of phylogeny,root traits and environmental factors.These findings necessitate accurate representations of tree evolutionary history in earth system models to predict fine root longevity and its responses to global changes.
基金supported by Huzhou Natural Science Foundation Project(Nos.2022YZ04 and 2022YZ21)S&T Special Program of Huzhou(No.2023GZ03)National Natural Science Foundation of China(No.52172184)。
文摘The high specific capacity and low negative electrochemical potential of lithium metal anodes(LMAs),may allow the energy density threshold of Li metal batteries(LMBs)to be pushed higher.However,the existing detrimental issues,such as dendritic growth and volume expansion,have hindered the practical implementation of LMBs.Introducing three-dimensional frameworks(e.g.,copper and nickel foam),have been regarded as one of the fundamental strategies to reduce the local current density,aiming to extend the Sand'time.Nevertheless,the local environment far from the skeleton is almost the same as the typical plane Li,due to macroporous space of metal foam.Herein,we built a double-layered 3D current collector of Li alloy anchored on the metal foam,with micropores interconnected macropores,via a viable thermal infiltration and cooling strategy.Due to the excellent electronic and ionic conductivity coupled with favorable lithiophilicity,the Li alloy can effectively reduce the nucleation barrier and enhance the Li^(+)transportation rate,while the metal foam can role as the primary promotor to enlarge the surface area and buffer the dimensional variation.Synergistically,the Li composite anode with hierarchical structure of primary and secondary scaffolds realized the even deposition behavior and minimum volume expansion,outputting preeminent prolonged cycling performances under high rate.
基金Key Collaborative Research Program of the Alliance of International Science Organizations(ANSO-CR-KP-2021-12 to L.L.)National Natural Science Foundation of China(32071009,32371063,82341248 to C.L.,31971072 and 32171154 to L.L.)+1 种基金Guangdong Basic and Applied Basic Research Foundation(2024A1515011500 to C.L.)Shenzhen Science Technology and Innovative Commission(SZSTI JCYJ20180508152336419 to L.L.and GJHZ20200731095406021 to S.J.)。
文摘The organ-specific toxicity resulting from microplastic(MP)exposure has been extensively explored,particularly concerning the gut,liver,testis,and lung.However,under natural conditions,these effects are not restricted to specific organs or tissues.Investigating whether MP exposure presents a systemic threat to an entire organism,impacting factors such as lifespan,sleep,and fecundity,is essential.In this study,we investigated the effects of dietary exposure to two different doses of MPs(1–5μm)using the terrestrial model organism Drosophila melanogaster.Results indicated that the particles caused gut damage and remained within the digestive system.Continuous MP exposure significantly shortened the lifespan of adult flies.Even short-term exposure disrupted sleep patterns,increasing the length of daytime sleep episodes.Additionally,one week of MP exposure reduced ovary size,with a trend towards decreased egg-laying in mated females.Although MPs did not penetrate the brain or ovaries,transcriptome analysis revealed altered gene expression in these tissues.In the ovary,Gene Ontology(GO)analysis indicated genotoxic effects impacting inflammation,circadian regulation,and metabolic processes,with significant impacts on extracellular structure-related pathways.In the brain,GO analysis identified changes in pathways associated with proteolysis and carbohydrate metabolism.Overall,this study provides compelling evidence of the systemic negative effects of MP exposure,highlighting the urgent need to address and mitigate environmental MP pollution.
基金granted by National Key Research and Development Program(No.2022YFF0801803)National Natural Science Foundation of China(No.42161144008).
文摘Enhancing forest cover is important for effective climate change mitigation.Studies suggest that drylands are promising areas for expanding forests,but conflicts arise with increased forest area and water consumption.Recent tree mortality in drylands raises concerns about carbon sequestration potential in tree plantations.Using Chinese dryland tree plantations as an example,we compared their growth with natural forests.Our results suggested plantation trees grew 1.6–2.1 times faster in juvenile phases,significantly shortening time to maturity(13.5 vs.30 years)compared to natural forests,potentially stemming from simple plantation age structures.Different from natural forests,74%of trees in plantations faced growth decline,indicating a short“prime period”for carbon sequestration and even a short lifespan.Additionally,a negative relationship between evapotranspiration and tree growth was observed in tree plantations since maturity,leading to high sensitivities of trees to vapor pressure deficit and soil water.However,this was not observed in natural forests.To address this,we suggest afforestation in drylands should consider complex age structures,ensuring a longer prime period for carbon sequestration and life expectancy in tree plantations.
基金financially supported by the Natural Science Foundation of Shandong Province(ZR2021QB055,ZR2023MB017,ZR2022JQ10)the National Natural Science Foundation of China(21901146,220781792,22274083)。
文摘Constructing heterostructure is considered as an effective strategy to address the sluggish electronic and ionic kinetics of anode materials for sodium ion batteries(SIBs).However,realizing the orientated growth and uniform distribution of the heterostructure is still a great challenge.Herein,the regulated novel CoSe_(2)/NiSe_(2)heterostructure confined in N-doped carbon nanofibers(CoSe_(2)/NiSe_(2)@N-C)are prepared by using Co/Ni-ZIF template,in which,the CoSe_(2)/NiSe_(2)heterostructures realize uniform distribution on a micro level.Benefiting from the unique heterostructure and N-doped carbon nanofibers,the CoSe_(2)/NiSe_(2)@N-C deliveries superior rate capability and durable cycle lifespan with a reversible capacity of 400.5 mA h g^(-1)after 5000 cycles at 2 A g^(-1).The Na-ion full battery with CoSe_(2)/NiSe_(2)@N-C anode and layered oxide cathode displays a remarkable energy density of 563 W h kg^(-1)with 241.1 W kg^(-1)at 0.1 A g^(-1).The theoretical calculations disclose that the periodic and directional built-in electric-field along with the heterointerfaces of CoSe_(2)/NiSe_(2)@N-C can accelerate electrochemical reaction kinetics.The in(ex)situ experimental measurements reveal the reversible conversion reaction and stable structure of CoSe_(2)/NiSe_(2)@N-C during Na+insertion/extraction.The study highlights the potential ability of precisely controlled heterostructure to stimulate the electrochemical performances of advanced anode for SIBs.
基金supported by the National Key R&D Program of China(No.2020YFC1910200)the National Natural Science Foundation of China(Nos.51873011 and U1664251).
文摘The progress of zinc(Zn)metal batteries(ZMBs)is greatly limited by poor cycling stability because of the mutual restrictions of dendrite growth,corrosion reactions,and passivation.In this work,an ultralong lifespan(~7800 h),dendrite-free Zn metal anode is enabled via fabricating a functional hydrogel electrolyte out of polyacrylamide/graphene oxide(GO)/agarose(PGA)with a multifully cross-linked network.The synergetic integration of GO nanosheets and double-network structure endows the PGA hydrogel electrolyte with high ionic conductivity and excellent mechanical performance.More importantly,the abundant hydrophilic groups and stable three-dimensional cross-linked network of PGA electrolyte effectively constrain Zn^(2+)diffusion laterally along the Zn surface,which simultaneously prohibits waterinduced corrosion and thus significantly enhances Zn anode reversibility.Both theoretical simulations and experiments reveal that the PGA electrolyte is capable of optimizing de-solvation kinetics and harmonizing Zn^(2+)flux at the electrolyte-electrode interface,ensuring uniform Zn^(2+)deposition.Consequently,an ultra-long lifespan of 7800 h is achieved in the symmetric cell with the PGA electrolyte.Even at a high Zn utilization of 42.7%,it still delivers stable cycling over 1100 h.This work provides a practical and beneficial approach to dramatically extending the lifespan of the Zn anode and thus achieving high-performance ZMBs.
基金supported by the National Natural Science Foundation of China (No. 30771113,30870810)the Program for New Century Excellent Talents in Universityprovided by the Caenorhabditis Genetics Center (Funded by the NIH,National Center for Foundation from Research Resource,USA)
文摘We used toxicity identification evaluation （TIE） method to confirm the combinational effects of identified toxic metals in a paper recycling mill effluent in inducing the decreased lifespan in nematode Caenorhabditis elegans.Exposure to Ca ＋ Al caused more severely decreased lifespan than that exposed to Ca,or Al;and exposure to Ca ＋ Fe induced more severely decreased lifespan than that exposed to Ca,or Fe.Exposure to Ca＋Al＋Fe caused more severely decreased lifespan than that exposed to Ca,or Ca＋Fe.Moreover,the baseline toxicity on lifespan was doubled by doubling the concentration of combined metals （Ca＋Al＋Fe） in spiking test in original effluent （oe）,and lifespan defects in oe＋Ca＋Al＋Fe exposed nematodes were more severe than that in Ca＋Al＋Fe exposed nematode.Therefore,Ca＋Al＋Fe exposure may largely explain the formation of decreased lifespan induced by the examined industrial effluent.Furthermore,the observed reduction of lifespan induced by the combination of high level of Ca with other metals may be at least partially independent of the insulin-like pathway.
基金supported by the National Science Foundation of China(Nos.31071087 and 30771217) the National Basic Research Program(973 Program)(No. 2009CB918702)
文摘CoQ is an essential electron cartier in the mitochondrial respiratory chain of both eukaryotes and prokaryotes. It consists of a benzoquinone head group and a hydrophobic polyisoprenoid tail. The genes （COQ1-9） involved in CoQ biosynthesis have been characterized in yeast. In this study, we generated and molecularly characterized a mutant allele of a novel Drosophila gene, sbo, which encodes a protein that is predicted to catalyze the prenylation of p-hydroxybenzoate with the isoprenoid chain during the process of CoQ synthesis. Expression of sbo in yeast rescues the lethality of ACOQ2 mutant cells, indicating that sbo is a functional homolog of COQ2. HPLC results show that the levels of CoQ9 and COQlo were significantly reduced in sbo heterozygous adult flies. Furthermore, the mean lifespans of males and females heterozygous for sbo are extended by 12.5% and 30.8%, respectively. Homozygous sbo animals exhibit reduced activities of the insulin/insulin-like growth factor signaling （IIS） pathway. Taken together, we conclude that sbo is an essential gene for Drosophila development, mutation of which leads to an extension of lifespan most likely by altering endogenous CoQ biosynthesis.
基金supported by the National Natural Science Foundation of China(Grant Nos.31830094 and 31902215)the Hi-Tech Research and Development 863 Program of China(Grant No.2013AA102507)+2 种基金the Fundamental Research Funds for the Central Universities in China(No.XDJK2019C014)Project funded by Chongqing Special Postdoctoral Science Foundation(Grant No.XmT2018058)Funds of China Agricultural Research System(No.CARS-18-ZJ0102)。
文摘A number of research has shown that the plant polyphenol resveratrol,one of the most prominent small molecules,has beneficial protective effects in multiple organisms,including worms,flies,and killifish.To understand the effects of resveratrol on lifespan,we evaluated its effects in the silkworm Bombyx mori.In this study,we found that lifespan was significantly prolonged in both female and male silkworms treated with resveratrol.Silkworm larval weight was significantly increased from day 3 of the 5th larval instar(L5D3)to day 7 of the 5th larval instar(L5D7).However,the weight of the pupa,cocoon,and total cocoon was not significantly different in female silkworms with resveratrol treatment than that in controls.Meanwhile,resveratrol significantly improved the thermotolerance of the silkworms,which enhanced their survival rate.Moreover,antioxidant activity was increased by resveratrol in both female and male silkworms.Furthermore,an antioxidant-related signalling pathway,SIRT7-FoxO-GST,was activated in silkworms with resveratrol treatment.Collectively,these results help us to understand the molecular pathways underlying resveratrol induced pro-longevity effects and indicate that silkworm is a promising animal model for evaluating the effects of lifespan-extending drugs.
基金supported by the Incheon National University Research Grant in 2015
文摘Seismic hazard levels lower than those for design of new buildings have been permitted for seismic evaluation and retrofi t of existing buildings due to the relatively short remaining lifespans. The seismic hazard reduction enables costeff ective seismic evaluation and retrofi t of existing buildings with limited structural capacity. The current study proposes seismic hazard reduction factors for Korea, one of low to moderate seismicity regions. The seismic hazard reduction factors are based on equal probabilities of non-exceedance within diff erent remaining building lifespans. A validation procedure is proposed to investigate equality of seismic risk in terms of ductility-based limit states using seismic fragility assessment of nonlinear SDOF systems, of which retrofi t demands are determined by the displacement coeffi cient method of ASCE 41-13 for diff erent target remaining building lifespans and corresponding reduced design earthquakes. Validation result shows that the use of seismic hazard reduction factors can be permitted in conjunction with appropriate lower bounds of the remaining building lifespans.
基金supported by National Key R&D Program of China(2019YFC1606205)Natural Science Foundation of China(32172136)Jiangsu distinguished professor project and Talent plan of Taihu Lake.
文摘As an irreplaceable dietary constituent,lipids play a vital important role in health,but their effects on aging process and longevity are still not well known yet.In this paper,the metabolic profiling and gene expression levels of Caenorhabditis elegans were investigated to explore the effects of different edible oils on senescence and lifespan.The results showed that teaseed oil(TO)could prolong the life expectancy and slow down the aging process of C.elegans.Compared to the control group,the intake of lard oil(LO)and TO increased the expression levels of genes related to inhibition of protein aggregation(akt-1,daf-16,hsf-1,hsp-16.2)and lipid metabolism(daf-7,daf-1,mdt-15,lipl-4,fat-5,fat-6,fat-7),with a more significant alteration in TO group.Metabolomics revealed that palm oil can upregulated plenty of fatty acids(palmitic acid,stearic acid,tetracosanoic acid),together with some amino acids(tryptophan,L-aspartate,L-valine)and carbohydrate(D-glucose),while the trend was opposite in TO group.Besides,moderate-to-strong correlations were found between differential metabolites and changed genes.In general,this paper claimed that TO could prolong lifespan and slow down aging process via regulating the lipids,amino acids and carbohydrates metabolism.
文摘Recent discoveries show steady improvements in life expectancy during modern decades. Does this support that humans continue to live longer in future? We recently put forward the maximum survival tendency, as found in survival curves of industrialized countries, which is described by extended Weibull model with agedependent stretched exponent. The maximum survival ten dency suggests that human survival dynamics may possess its intrinsic limit, beyond which survival is inevitably forbidden. Based on such tendency, we develop the model and explore the patterns in the maximum lifespan limits from industrialized countries during recent three decades. This analysis strategy is simple and useful to interpret the complicated human survival dynamics.
文摘Currently, the electrical system in Argentina is working at its maximum capacity, decreasing the margin between the installed power and demanded consumption, and drastically reducing the service life of transformer substations due to overload (since the margin for summer peaks is small). The advent of the Smart Grids allows electricity distribution companies to apply data analysis techniques to manage resources more efficiently at different levels (avoiding damages, better contingency management, maintenance planning, etc.). The Smart Grids in Argentina progresses slowly due to the high costs involved. In this context, the estimation of the lifespan reduction of distribution transformers is a key tool to efficiently manage human and material resources, maximizing the lifetime of this equipment. Despite the current state of the smart grids, the electricity distribution companies can implement it using the available data. Thermal models provide guidelines for lifespan estimation, but the adjustment to particular conditions, brands, or material quality is done by adjusting parameters. In this work we propose a method to adjust the parameters of a thermal model using Genetic Algorithms, comparing the estimation values of top-oil temperature with measurements from 315 kVA distribution transformers, located in the province of Tucumán, Argentina. The results show that, despite limited data availability, the adjusted model is suitable to implement a transformer monitoring system.
基金This work was supported by South-West Jiaotong University Foundation
文摘The authors consider the Cauchy problem for the following nonlinear wave equationswhere x ∈ R3, t ≥ 0, ε > 0 is a small parameter, and obtain the sharp bounds for the lifespan of solution to (0.1). Specially, it is proved that there exist two constants C1 and C2, which are independent of ε, then the lifespan T(ε) satisfies the folowing inequalities
基金the Innovative Key Project of the Chinese Academy of Sciences (KZCX-YW-209).
文摘The effects of degraded porphyran (P1) and natural porphyran (P) on the lifespan and vitality of Drosophila melanogaster are studied. The porphyrans, added daily to the food medium at 0.2% and 1% concentrations, can significantly increase the lifespan in average of 55.79 and 58.23 d in 0.2% P1 diet females and 1% P1 diet males, extending by 12.29% and 8.60% over the corresponding controls, respectively. The effects of porphyrans on D. melanogaster in heat-stress condition were also examined, and found a remarkable increase in survival time. The results which are consistently associated with the use of porphyrans are related to their free radical scavenger action. Considerable increase in vitality demonstrated that vitalities of middle-aged fly (assessed by measuring their mating capacity) was observed after porphyrans addition. Therefore, porphyrans are effective in reducing the rate of aging, and P1 in low molecular weight is better than natural P.
文摘Aim β-guanadinopropionic acid （β-6PA）, a creatine analog has been demonstrated to lead to thechronic activation of AMPK with increasing mitochondrial biogenesis. However, little is known about the effect of β-GPA on lifespan extension. In current study, we explore whether β-GPA produces the lifespan extension in adult Drosophila and underlying mechanism. Methods The flies were fed in a normal chow diet containing different concentrations （300 raM,900 mM,2700 mM）of β-GPA. Western blot was also used to investigate protein expres- sions. RNA interference was employed to examine effects of lifespan in Drosophila by 13-GPA. Results 900 mM and 2700 mM β-GPA significant extended the lifespan and activated AMPK both in male and female Drosophila with elevated level of autophagy. We found that Atg8 was significantly upregulated and P62 was significantly down- regulated by 900 mM 13-GPA, on the other hand, when the expression of Atg5 protein, an essential protein for au- tophagy, was reduced by RNAi, the effect of β-GPA on lifespan extension was abolished. Inhibition of AMPK by either AMPK-RNAi or compound （2, significantly attenuated the expression of autophagy-related proteins and lifes- pan extension in Drosophila. We found that the activation of AMPK induced by β-GPA inhibited mTORC1 activity, implicating that mTORC1 may not prevent the activation of ULK1/Atgl by AMPK. Conclusion β-GPA can ex- tend the lifespan of Drosophila and this effect is mediated by AMPK-Atgl dependent autophagy.
