Ferroptosis of chondrocytes is a significant contributor to osteoarthritis(OA),for which there is still a lack of safe and effective therapeutic drugs targeting ferroptosis.Here,we screen for anti-ferroptotic drugs in...Ferroptosis of chondrocytes is a significant contributor to osteoarthritis(OA),for which there is still a lack of safe and effective therapeutic drugs targeting ferroptosis.Here,we screen for anti-ferroptotic drugs in Food and Drug Administration(FDA)-approved drug library via a high-throughput manner in chondrocytes.We identified a group of FDA-approved anti-ferroptotic drugs,among which vitamin K showed the most powerful protective effect.Further study demonstrated that vitamin K effectively inhibited ferroptosis and alleviated the extracellular matrix(ECM)degradation in chondrocytes.Intra-articular injection of vitamin K inhibited ferroptosis and alleviated OA phenotype in destabilization of the medial meniscus(DMM)mouse model.Mechanistically,transcriptome sequencing and knockdown experiments revealed that the anti-ferroptotic effects of vitamin K depended on growth arrest-specific 6(Gas6).Furthermore,exogenous expression of Gas6 was found to inhibit ferroptosis through the AXL receptor tyrosine kinase(AXL)/phosphatidylinositol 3-kinase(PI3K)/AKT serine/threonine kinase(AKT)axis.Together,we demonstrate that vitamin K inhibits ferroptosis and alleviates OA progression via enhancing Gas6 expression and its downstream pathway of AXL/PI3K/AKT axis,indicating vitamin K as well as Gas6 to serve as a potential therapeutic target for OA and other ferroptosis-related diseases.展开更多
通过对国内外Living Library的考察,结合Web2.0和社会性网络SNS的发展,提出了一个基于SNS的Living Library虚拟社区模型:Virtual Living Library(简称VLL),并就VLL的概念模型的构建、实践和评价等方面进行了论述,讨论了VLL的建设可能性...通过对国内外Living Library的考察,结合Web2.0和社会性网络SNS的发展,提出了一个基于SNS的Living Library虚拟社区模型:Virtual Living Library(简称VLL),并就VLL的概念模型的构建、实践和评价等方面进行了论述,讨论了VLL的建设可能性和发展前景。展开更多
The aim of this article is to present a unique interpretation of the holistic worldview,both in theory and in practice.It explores how this approach,along with a planning process fundamentally different from conventio...The aim of this article is to present a unique interpretation of the holistic worldview,both in theory and in practice.It explores how this approach,along with a planning process fundamentally different from conventional methods,was implemented in the design and construction of the Music Center and Library in the city of Tel Aviv.This process forms a coherent representation of a complete worldview:a humanistic,holistic worldview developed and adopted through more than five decades of architectural practice across all scales of design.In this approach,a building is not regarded as a collection of isolated design elements,but as one hierarchical language,in which the building,its interior,and its ornamented details down to the handle of the door is one continuous system.Within this system,the building,its interior spaces,and even the smallest ornamental details,down to the door handles,are conceived as parts of a single,continuous whole.This worldview aligns with contemporary scientific discourse in fields such as cosmology,neurobiology,psychology,complexity theory,and Buddhist philosophy,disciplines with which this body of work is closely associated.展开更多
Building on the self-regulation theory and the gap model of service quality,this study proposes a conceptual model for investigating the help-seeking behavior of library users and the behaviors’underlying mechanisms ...Building on the self-regulation theory and the gap model of service quality,this study proposes a conceptual model for investigating the help-seeking behavior of library users and the behaviors’underlying mechanisms in the context of university libraries.The study focuses on university students as the research participants,and employs a questionnaire survey to collect data.The data is then analyzed,and the model is evaluated using the regression and bootstrap methods.The results indicate that library anxiety can lead to help-seeking behavior,while it also diminishes the users’perception of their interaction quality with the librarians.Moreover,the interaction quality positively influences help-seeking behavior,and self-efficacy and artificial intelligence services exhibit both direct and indirect negative regulatory effects.展开更多
Objective:To enhance the reading skills of clinical pathology residents,it is essential to establish a well-structured electronic pathology reading library.Methods:In accordance with the Resident Standardization Train...Objective:To enhance the reading skills of clinical pathology residents,it is essential to establish a well-structured electronic pathology reading library.Methods:In accordance with the Resident Standardization Training Content and Standards(2022 Edition),clinical pathology residents are required to master pathological diagnoses across 11 systems:skin,head and neck,mediastinum and respiratory,digestive,urinary and male reproductive,female reproductive and breast,lymphatic and hematopoietic,bone and soft tissue,cardiovascular,central nervous,and endocrine diseases.Senior pathologists specializing in each subspecialty selected classic pathological slides,which were systematically scanned and compiled into an electronic pathology library.Results:A questionnaire survey was conducted to gather feedback on the electronic pathology reading library.Residents generally found it to be convenient,efficient,and conducive to learning.Conclusion:Training in clinical pathology diagnosis is a core component of standardized resident training.The electronic pathology reading library has been well-received and recognized by resident doctors.However,further efforts are needed to explore diverse teaching methods that align with modern educational approaches,ultimately contributing to the development of highly skilled resident doctors.展开更多
As an important method of practical teaching,case-based teaching has become increasingly prominent in international Chinese language education.However,the development of case-based teaching for Chinese characters rema...As an important method of practical teaching,case-based teaching has become increasingly prominent in international Chinese language education.However,the development of case-based teaching for Chinese characters remains insufficient,with limited research outcomes,making it difficult to effectively support the teaching and research of Chinese character instruction.The establishment of a case library for international Chinese character teaching can provide a wealth of teaching cases,meeting the developmental needs of international Chinese language education in the new era.展开更多
This article introduces several of the more significant service delivery innovations and their resulting accomplishments instigated by Dongguan Library(thereafter abbreviated as DGL) in recent years. The textual expos...This article introduces several of the more significant service delivery innovations and their resulting accomplishments instigated by Dongguan Library(thereafter abbreviated as DGL) in recent years. The textual exposition of this paper is based on a case study of DGL by this author about its user-centered vision, mission, immediate objectives and the exhibited service performance within a contextual environment of collegial support from its professional peers. After a five-year period of intensive efforts on such focused professional development and practice, DGL has completed its information service mapping and information delivery for the entire municipality of Dongguan on a 7-day and twentyfour-hour(7/24) basis. This singular feast of accomplishment seems to suggest the moral that any significant development of scale of a municipal library has to be in keeping pace closely with the progress of the society at large in general and with the changing information demands of its local clientele in particular.展开更多
学术界一些研究者认为"Personal Digital Library"与"MyLibrary"均可指个人数字图书馆。然而,两者是不同概念、特征及功能的事物。论文对两者的概念、研究现状及趋势作了详细的论述,旨在揭示这两种事物,为后续研究...学术界一些研究者认为"Personal Digital Library"与"MyLibrary"均可指个人数字图书馆。然而,两者是不同概念、特征及功能的事物。论文对两者的概念、研究现状及趋势作了详细的论述,旨在揭示这两种事物,为后续研究者提供借鉴。展开更多
Digital libraries are complex systems and this brings difficulties for their evaluation. This paper proposes a hierarchical model to solve this problem, and puts the entangled matters into a clear-layered structure. F...Digital libraries are complex systems and this brings difficulties for their evaluation. This paper proposes a hierarchical model to solve this problem, and puts the entangled matters into a clear-layered structure. Firstly, digital libraries(DLs thereafter)are classified into 5 groups in ascending gradations, i.e. mini DLs, small DLs, medium DLs,large DLs, and huge DLs by their scope of operation. Then, according to the characteristics of DLs at different operational scope and level of sophistication, they are further grouped into unitary DLs, union DLs and hybrid DLs accordingly. Based on this simulated structure,a hierarchical model for digital library evaluation is introduced, which evaluates DLs differentiatingly within a hierarchical scheme by using varying criteria based on their specific level of operational complexity such as at the micro-level, medium-level, and/or at the macro-level. Based on our careful examination and analysis of the current literature about DL evaluation system, an experiment is conducted by using the DL evaluation model along with its criteria for unitary DLs at micro-level. The main contents resulting from this evaluation experimentation and also those evaluation indicators and relevant issues of major concerns for DLs at medium-level and macro-level are also to be presented at some length.展开更多
As an important part of National Digital Library(NDL),the National Digital Library Project(NDLP),which was launched in 2005,has attracted wide attention of the society in general.This paper introduces the general situ...As an important part of National Digital Library(NDL),the National Digital Library Project(NDLP),which was launched in 2005,has attracted wide attention of the society in general.This paper introduces the general situation of the project from the following aspects,namely,the characteristics,objectives and contents.It also expounds on the basic ideas and the overall structure of the project and gives an introduction to the design of its basic platform,its application platform,its business management system and its standardization control system.In this paper,the digital resources construction and service delivery of the National Library of China(NLC)are introduced to cover both its present operation as well as those in conjunction with the opening of its new library building during its second-phase of library development.Finally,the most important and difficult point in the construction of the National Digital Library Project is analyzed from the following four perspectives:1)The long-term preservation of digital resources;2)the construction of knowledge organization system;3)the organic integration of the digital library and the traditional library;and 4)the risk of project management and system integration.展开更多
Journal of the Chinese Library Association is an agency publication of the Chinese Library Association.Its purpose is to promote the exchange of library science,the popularization of library science knowledge,and the ...Journal of the Chinese Library Association is an agency publication of the Chinese Library Association.Its purpose is to promote the exchange of library science,the popularization of library science knowledge,and the development of library undertakings.The journal has numerous columns,rich content,long publication time and wide distribution,laying an important foundation for the innovation,transformation and development of modern library cause.展开更多
The cDNA library normalized by reassociation is a newly-developed and effective platform for EST acquisition and gene discovery.It decreases the prevalence of clones representing abundant transcripts and dramatically ...The cDNA library normalized by reassociation is a newly-developed and effective platform for EST acquisition and gene discovery.It decreases the prevalence of clones representing abundant transcripts and dramatically increases the efficiency of random sequencing and rare gene discovery.The principle,procedure and applications of normalized cDNA library were reviewed in this paper,which provides theoretical basis for the development of normalized cDNA library and discover more novel genes.展开更多
基金supported by grants from the Wenzhou Science and Technology Bureau Foundation,China(Grant No.:ZY2019014)“Pioneer”and“Leading Goose”R&D Program of Zhejiang,China(Grant No.:2022C03144)National Natural Science Foundation of China(Grant Nos.:82172494,and 82372461).
文摘Ferroptosis of chondrocytes is a significant contributor to osteoarthritis(OA),for which there is still a lack of safe and effective therapeutic drugs targeting ferroptosis.Here,we screen for anti-ferroptotic drugs in Food and Drug Administration(FDA)-approved drug library via a high-throughput manner in chondrocytes.We identified a group of FDA-approved anti-ferroptotic drugs,among which vitamin K showed the most powerful protective effect.Further study demonstrated that vitamin K effectively inhibited ferroptosis and alleviated the extracellular matrix(ECM)degradation in chondrocytes.Intra-articular injection of vitamin K inhibited ferroptosis and alleviated OA phenotype in destabilization of the medial meniscus(DMM)mouse model.Mechanistically,transcriptome sequencing and knockdown experiments revealed that the anti-ferroptotic effects of vitamin K depended on growth arrest-specific 6(Gas6).Furthermore,exogenous expression of Gas6 was found to inhibit ferroptosis through the AXL receptor tyrosine kinase(AXL)/phosphatidylinositol 3-kinase(PI3K)/AKT serine/threonine kinase(AKT)axis.Together,we demonstrate that vitamin K inhibits ferroptosis and alleviates OA progression via enhancing Gas6 expression and its downstream pathway of AXL/PI3K/AKT axis,indicating vitamin K as well as Gas6 to serve as a potential therapeutic target for OA and other ferroptosis-related diseases.
文摘通过对国内外Living Library的考察,结合Web2.0和社会性网络SNS的发展,提出了一个基于SNS的Living Library虚拟社区模型:Virtual Living Library(简称VLL),并就VLL的概念模型的构建、实践和评价等方面进行了论述,讨论了VLL的建设可能性和发展前景。
文摘The aim of this article is to present a unique interpretation of the holistic worldview,both in theory and in practice.It explores how this approach,along with a planning process fundamentally different from conventional methods,was implemented in the design and construction of the Music Center and Library in the city of Tel Aviv.This process forms a coherent representation of a complete worldview:a humanistic,holistic worldview developed and adopted through more than five decades of architectural practice across all scales of design.In this approach,a building is not regarded as a collection of isolated design elements,but as one hierarchical language,in which the building,its interior,and its ornamented details down to the handle of the door is one continuous system.Within this system,the building,its interior spaces,and even the smallest ornamental details,down to the door handles,are conceived as parts of a single,continuous whole.This worldview aligns with contemporary scientific discourse in fields such as cosmology,neurobiology,psychology,complexity theory,and Buddhist philosophy,disciplines with which this body of work is closely associated.
基金supported by the Major Project of the Sichuan Academy of Social Sciences(Project No.24ZD04).
文摘Building on the self-regulation theory and the gap model of service quality,this study proposes a conceptual model for investigating the help-seeking behavior of library users and the behaviors’underlying mechanisms in the context of university libraries.The study focuses on university students as the research participants,and employs a questionnaire survey to collect data.The data is then analyzed,and the model is evaluated using the regression and bootstrap methods.The results indicate that library anxiety can lead to help-seeking behavior,while it also diminishes the users’perception of their interaction quality with the librarians.Moreover,the interaction quality positively influences help-seeking behavior,and self-efficacy and artificial intelligence services exhibit both direct and indirect negative regulatory effects.
文摘Objective:To enhance the reading skills of clinical pathology residents,it is essential to establish a well-structured electronic pathology reading library.Methods:In accordance with the Resident Standardization Training Content and Standards(2022 Edition),clinical pathology residents are required to master pathological diagnoses across 11 systems:skin,head and neck,mediastinum and respiratory,digestive,urinary and male reproductive,female reproductive and breast,lymphatic and hematopoietic,bone and soft tissue,cardiovascular,central nervous,and endocrine diseases.Senior pathologists specializing in each subspecialty selected classic pathological slides,which were systematically scanned and compiled into an electronic pathology library.Results:A questionnaire survey was conducted to gather feedback on the electronic pathology reading library.Residents generally found it to be convenient,efficient,and conducive to learning.Conclusion:Training in clinical pathology diagnosis is a core component of standardized resident training.The electronic pathology reading library has been well-received and recognized by resident doctors.However,further efforts are needed to explore diverse teaching methods that align with modern educational approaches,ultimately contributing to the development of highly skilled resident doctors.
基金the research result of the 2022 International Chinese Education Research Project“Construction and Research of International Chinese Character Teaching Case Library in Chinese Education”(22YH88D).
文摘As an important method of practical teaching,case-based teaching has become increasingly prominent in international Chinese language education.However,the development of case-based teaching for Chinese characters remains insufficient,with limited research outcomes,making it difficult to effectively support the teaching and research of Chinese character instruction.The establishment of a case library for international Chinese character teaching can provide a wealth of teaching cases,meeting the developmental needs of international Chinese language education in the new era.
文摘This article introduces several of the more significant service delivery innovations and their resulting accomplishments instigated by Dongguan Library(thereafter abbreviated as DGL) in recent years. The textual exposition of this paper is based on a case study of DGL by this author about its user-centered vision, mission, immediate objectives and the exhibited service performance within a contextual environment of collegial support from its professional peers. After a five-year period of intensive efforts on such focused professional development and practice, DGL has completed its information service mapping and information delivery for the entire municipality of Dongguan on a 7-day and twentyfour-hour(7/24) basis. This singular feast of accomplishment seems to suggest the moral that any significant development of scale of a municipal library has to be in keeping pace closely with the progress of the society at large in general and with the changing information demands of its local clientele in particular.
文摘Digital libraries are complex systems and this brings difficulties for their evaluation. This paper proposes a hierarchical model to solve this problem, and puts the entangled matters into a clear-layered structure. Firstly, digital libraries(DLs thereafter)are classified into 5 groups in ascending gradations, i.e. mini DLs, small DLs, medium DLs,large DLs, and huge DLs by their scope of operation. Then, according to the characteristics of DLs at different operational scope and level of sophistication, they are further grouped into unitary DLs, union DLs and hybrid DLs accordingly. Based on this simulated structure,a hierarchical model for digital library evaluation is introduced, which evaluates DLs differentiatingly within a hierarchical scheme by using varying criteria based on their specific level of operational complexity such as at the micro-level, medium-level, and/or at the macro-level. Based on our careful examination and analysis of the current literature about DL evaluation system, an experiment is conducted by using the DL evaluation model along with its criteria for unitary DLs at micro-level. The main contents resulting from this evaluation experimentation and also those evaluation indicators and relevant issues of major concerns for DLs at medium-level and macro-level are also to be presented at some length.
基金supported by the Ministry of Education of P.R.China(Grant No.07JJD870221)
文摘As an important part of National Digital Library(NDL),the National Digital Library Project(NDLP),which was launched in 2005,has attracted wide attention of the society in general.This paper introduces the general situation of the project from the following aspects,namely,the characteristics,objectives and contents.It also expounds on the basic ideas and the overall structure of the project and gives an introduction to the design of its basic platform,its application platform,its business management system and its standardization control system.In this paper,the digital resources construction and service delivery of the National Library of China(NLC)are introduced to cover both its present operation as well as those in conjunction with the opening of its new library building during its second-phase of library development.Finally,the most important and difficult point in the construction of the National Digital Library Project is analyzed from the following four perspectives:1)The long-term preservation of digital resources;2)the construction of knowledge organization system;3)the organic integration of the digital library and the traditional library;and 4)the risk of project management and system integration.
文摘Journal of the Chinese Library Association is an agency publication of the Chinese Library Association.Its purpose is to promote the exchange of library science,the popularization of library science knowledge,and the development of library undertakings.The journal has numerous columns,rich content,long publication time and wide distribution,laying an important foundation for the innovation,transformation and development of modern library cause.
基金Supported by the 973 Program of China (No. 2006CB101600)~~
文摘The cDNA library normalized by reassociation is a newly-developed and effective platform for EST acquisition and gene discovery.It decreases the prevalence of clones representing abundant transcripts and dramatically increases the efficiency of random sequencing and rare gene discovery.The principle,procedure and applications of normalized cDNA library were reviewed in this paper,which provides theoretical basis for the development of normalized cDNA library and discover more novel genes.
