This paper exhibits the construction and development of Acupuncture and Moxibustion Hospital of China Academy of Chinese Medical Sciences(CACMS),based on Lian ZHU’s acupuncture academic thought,focusing on the practi...This paper exhibits the construction and development of Acupuncture and Moxibustion Hospital of China Academy of Chinese Medical Sciences(CACMS),based on Lian ZHU’s acupuncture academic thought,focusing on the practice of the hospital development during the past 74 years,from 1951 to 2025,and by analyzing the development trajectory and elaborating the four-dimensional collaborative development mode guided by Lian ZHU’s thought,grounded in clinical evidence,driven by scientific innovation,guided by international standards,and rooted in educational inheritance.(1)After more than 70 years of development,Acupuncture and Moxibustion Hospital of CACMS has developed into the typical small-scaled general hospital of traditional Chinese medicine(TCM)with acupuncture-moxibustion as the main intervention,and has obtained a fruitful achievement in academic research.(2)The Hospital has led and participated in the formulation of a number of clinical practice guidelines of China Association of Acupuncture and Moxibustion,is entitled as the World Health Organization Collaborating Centre for traditional medicine,and has been ranked among the top in the outpatient visits of acupuncture-moxibustion department of TCM hospitals in Beijing for years.(3)There is a well-known professional team of acupuncture-moxibustion of TCM in the Hospital,and with the characteristic modes of acupuncture-moxibustion diagnosis and treatment delivered,the remarkable curative effects have been obtained in treatment of diseases in neurological,gynecological diseases,orthopedic departments,as well as pain disorders,allergic diseases.(4)In the future,facing the opportunities and challenges in the development of global healthcare,it is necessary to deepen the research on“intelligent acupuncture and moxibustion”,integrating modern technologies such as artificial intelligence and big data,exploring the potential value of acupuncture and moxibustion,discovering and innovating theoretical research on acupuncture and moxibustion,establishing scientific methods,standardizing clinical operation techniques,and driving the creative transformation of TCM.(5)The hospital lays the great consideration to the cultivation of acupuncture-moxibustion talents by means of multiple approaches,in order to deeply grasp the essence of TCM and improve the comprehensive quality of talents.(6)The hospital keeps on the leading role of international communication,advancing the international exchange and cooperation of acupuncture and moxibustion,and contributes more eastern wisdom to global health governance,and promote acupuncture and moxibustion of TCM,the treasure of the Chinese nation to display its importance in the world.展开更多
This study summarizes the clinical experience of professor LIAN Jianwei, a nationally renowned traditional Chinese medicine (TCM) practitioner, in treating chronic atrophic gastritis (CAG) with syndrome differentiatio...This study summarizes the clinical experience of professor LIAN Jianwei, a nationally renowned traditional Chinese medicine (TCM) practitioner, in treating chronic atrophic gastritis (CAG) with syndrome differentiation based on pulse-taking. Professor LIAN emphasizes the importance of pulse diagnosis in TCM clinical practice, focusing on the normal and variant aspects of pulse methods, and centers on the dynamic changes of the “Guan pulse” to accurately determine the functional status of the spleen and stomach based on pulse variations, thereby formulating personalized treatment plans. For patients with a slow and moderate pulse, spleen and stomach deficiency and dampness due to spleen deficiency are often identified, and treatment mainly focuses on strengthening the spleen, resolving dampness, and boosting Qi to aid transportation, usually with modifications of Shenling Baizhu San. When the left Guan pulse is string-like and the right Guan pulse is slow and moderate, it indicates liver depression and spleen deficiency, and Xiaoyao San is commonly used to soothe the liver, nourish the blood, and strengthen the spleen, harmonizing the liver and spleen. If the right Guan pulse is large and the left Guan pulse is string-like, it mostly belongs to liver and stomach Qi stagnation, and Bupleurum Liver-soothing powder is often used to soothe the liver, regulate Qi, and harmonize the stomach. A large and empty right Guan pulse suggests insufficiency of Central Qi, and Buzhong Yiqi Tang is commonly used to tonify Qi and soothe the liver. In terms of medication, professor LIAN pays attention to patients’ dietary habits and combines methods of eliminating dampness, promoting digestion, and activating blood circulation to improve symptoms and reverse atrophy.展开更多
Objective: To observe the therapeutic effect of different dosages of Gegen Qin Lian Decoction (葛根芩连汤) on type 2 diabetic patients. Methods: Fifty-four type 2 diabetic patients from low dosage group (20 cases), me...Objective: To observe the therapeutic effect of different dosages of Gegen Qin Lian Decoction (葛根芩连汤) on type 2 diabetic patients. Methods: Fifty-four type 2 diabetic patients from low dosage group (20 cases), medium dosage group (19 cases) and high dosage group (15 cases) were treated with different dosage of Gegen Qin Lian Decoction for 12 weeks. Fasting blood-glucose (FBG), postprandial blood sugar (PBG) and Hemoglobin A1c (HbAlc) were determined before and after treatment. Results: With the increase of dosage, the overall effective rate of glycaemic control increased, and FBG, PBG, HbAlc decreased. The overall effective rate of blood glucose control of high dosage, medium dosage and low dosage group were 80%, 47%, 30% respectively, and there were significant differences between high dosage group and low dosage group. The decrease of FBG, PBG and HbAlc of high dosage showed significant differences from low dosage too. These data was analyzed by trend χ2 test and covariance analysis. Conclusion: The result indicated that different dosage of Gegen Qin Lian Decoction has dose-effect relationship in reducing HbAlc and FBG.展开更多
Shuang-huang-lian Injection(SHLI) is the first successfully developed drug from traditional Chinese medicine(TCM) powder for injection,since its use for the treatment of acute respiratory tract infection,pneumonia,inf...Shuang-huang-lian Injection(SHLI) is the first successfully developed drug from traditional Chinese medicine(TCM) powder for injection,since its use for the treatment of acute respiratory tract infection,pneumonia,influenza,etc.At the same time,its allergic reactions have also emerged,which limits clinical applications.However,few scholars pay attention to the mechanism of allergic reactions.In this present study,metabonomics technology was used to explore the changes in endogenous metabolites in urine of the rat model of SHLI induced allergic reaction;we and analyzed the metabolites,metabolic pathway,and the mechanism which were closely related to the allergic reactions.The levels of serum histamine and tryptase were examined and changes in histomorphology were also observed.Based on the UPLC-Q-TOF/MS metabonomics,we carried out the pattern recognition analysis,selected potential biomarkers associated with allergic reactions,and explored the pathological mechanism for SHLI induced allergic reaction,which laid the foundation for the safety research of SHLI.Our results showed that SHLI increased the levels of serum histamine and tryptase in rats with allergic reaction;we determined 15 biomarkers in rat allergic reaction model induced by SHLI and found multiple metabolic pathways involved,such as metabolism of linolenic acid,phenylalanine,amino acid,2-oxo acid,and purine and other metabolic pathways.展开更多
With the advantages of less toxicity and side effects, traditional Chinese medicine(TCM) is showing a bright future with a good clinical practice. Chinese herbal medicine, which usually contains various active ingredi...With the advantages of less toxicity and side effects, traditional Chinese medicine(TCM) is showing a bright future with a good clinical practice. Chinese herbal medicine, which usually contains various active ingredients, could provide multiple therapeutic effects. Professor Tong Xiaolin has accumulated abundant experience during many years of clinical practice and applies Rhizoma Coptidis(RC) well with the treatment of diabetes and its complications. Rhizoma coptidis is a classical natural herb which is used frequently by professor Tong Xiaolin. In this review, we summarize Tong Xiaolin's clinical experience of applying Rhizoma Coptidis(Huang Lian) in the treatment of disease from two aspects as well as introducing some traditional Chinese medical theory and clinical experience, with a prospect of guiding clinician to use RC more suitably and reasonably.展开更多
OBJECTIVE To explore the anti-atherosclerotic effect of the extract of traditional Chinese medicine formula Dan-yi-lian(DYL) and the related mechanism.METHODS Atherosclerosis(AS) mod.el was established in ApoE(-/-) mi...OBJECTIVE To explore the anti-atherosclerotic effect of the extract of traditional Chinese medicine formula Dan-yi-lian(DYL) and the related mechanism.METHODS Atherosclerosis(AS) mod.el was established in ApoE(-/-) mice with a western diet.The mice were orally administered with differ.ent doses of DYL or vehicle daily for 28 d.The anti-atherosclerotic effect was evaluated by measuring the aortic atherosclerotic lesion area and media thickness with ultrasound imaging and histological sec.tions staining method.The effect on blood lipid was investigated by determining TC,TG,LDL,HDL,Apo-A1,Apo-B,etc.The anti-oxidative activity as assessed by determining the level of SOD,CAT,GSH,GSH-Px and MDA.Western blot analysis was used to determine the effect on ICAM-1,VCAM-1,MMP-2 and TNF-α.RESULTS In Dan-yi-lian administered ApoE(-/-) mice,the plaque area and media thickness were significantly reduced.Meanwhile,serum TC,TG,LDL and Apo-B were decreased,in contrast to the increased level of HDL and Apo-A1.On the other hand,SOD,CAT,GSH and GSH-Px were increased,while MDA was reduced in liver homogenate.In addition,the expression of ICAM-1,VCAM-1,MMP-2 and TNF-α was obviously inhibited by Dan-yi-lian.CONCLUSION Dan-yi-lian exhibit.ed potent anti-athero-sclerotic efficacy,in which the lipid-regulating,anti-oxidative and anti-inflammato.ry mechanism might be involved.展开更多
Objective： To observe the clinical effects of Zhu Lian＇s type Ⅰ excitation needling technique for postpartum urinary retention.Methods： A total of 60 cases with postpartum urinary retention were recruited and divi...Objective： To observe the clinical effects of Zhu Lian＇s type Ⅰ excitation needling technique for postpartum urinary retention.Methods： A total of 60 cases with postpartum urinary retention were recruited and divided randomly into an observation group and a control group, 30 cases in each group. The control group was treated with routine acupuncture, and stimulated with sparse and dense wave of electric acupuncture for 15 min after arrival of needling sensation, and then the needles were taken out. The observation group was treated with Zhu Lian＇s type Ⅰ excitation needling technique, by inserting the needles with the quick inserting method, swift and temporary lifting and thrusting technique for shallow insertion for 5times, by an in-and-out technique, without retaining the needles.Results： The total effective rate was 96.7% in the observation group and 83.3% in the control group. The difference in the total effective rate between the two groups was statistically significant（P〈0.05）. After the treatment, the first urination time was shorter in the observation group than that in the control group, with a statistical significance（P〈0.01）. After the treatment, the volume of residual urine after the first urination was less in the observation group than that in the control group（P〈0.01）.Conclusion： Zhu Lian＇s type Ⅰ excitation needling technique can effectively promote the voluntary urination and bladder emptying in patients with postpartum urinary retention, and it takes effect faster.展开更多
Professor LIAN Yu-lin dedicates himself to the cause of TCM and acupuncture, and puts forward some original ideas on the basic theory of acupuncture.In clinical practice, he devotes himself to the study of some diffic...Professor LIAN Yu-lin dedicates himself to the cause of TCM and acupuncture, and puts forward some original ideas on the basic theory of acupuncture.In clinical practice, he devotes himself to the study of some difficult and complicated illnesses in acupuncture,with excellent results.展开更多
OUR plane flew through white clouds, taking us to Sichuan Province for a visit to Dharmacarya Long Lian, who is honored the No.1 bhiksuni in China. At 86, respected by domestic and overseas Buddhists, this eminent nun...OUR plane flew through white clouds, taking us to Sichuan Province for a visit to Dharmacarya Long Lian, who is honored the No.1 bhiksuni in China. At 86, respected by domestic and overseas Buddhists, this eminent nun has had remarkable experiences. She is good at poetry and painting and of great attainments in Buddhism. She created the first bhiksuni Buddhist institute in China. After the plane landed in Chengdu, we took a taxi to the Tiexiang (Iron Statue) Monastery, a newly-renovated monastery beside lush green rice fields. A nun met us and led us into a shady courtyard in front展开更多
基金Supported by the Basic Scientific Research Business Foundation of the Institute of Acupuncture and Moxibustion,CACMS:ZZ-2023014。
文摘This paper exhibits the construction and development of Acupuncture and Moxibustion Hospital of China Academy of Chinese Medical Sciences(CACMS),based on Lian ZHU’s acupuncture academic thought,focusing on the practice of the hospital development during the past 74 years,from 1951 to 2025,and by analyzing the development trajectory and elaborating the four-dimensional collaborative development mode guided by Lian ZHU’s thought,grounded in clinical evidence,driven by scientific innovation,guided by international standards,and rooted in educational inheritance.(1)After more than 70 years of development,Acupuncture and Moxibustion Hospital of CACMS has developed into the typical small-scaled general hospital of traditional Chinese medicine(TCM)with acupuncture-moxibustion as the main intervention,and has obtained a fruitful achievement in academic research.(2)The Hospital has led and participated in the formulation of a number of clinical practice guidelines of China Association of Acupuncture and Moxibustion,is entitled as the World Health Organization Collaborating Centre for traditional medicine,and has been ranked among the top in the outpatient visits of acupuncture-moxibustion department of TCM hospitals in Beijing for years.(3)There is a well-known professional team of acupuncture-moxibustion of TCM in the Hospital,and with the characteristic modes of acupuncture-moxibustion diagnosis and treatment delivered,the remarkable curative effects have been obtained in treatment of diseases in neurological,gynecological diseases,orthopedic departments,as well as pain disorders,allergic diseases.(4)In the future,facing the opportunities and challenges in the development of global healthcare,it is necessary to deepen the research on“intelligent acupuncture and moxibustion”,integrating modern technologies such as artificial intelligence and big data,exploring the potential value of acupuncture and moxibustion,discovering and innovating theoretical research on acupuncture and moxibustion,establishing scientific methods,standardizing clinical operation techniques,and driving the creative transformation of TCM.(5)The hospital lays the great consideration to the cultivation of acupuncture-moxibustion talents by means of multiple approaches,in order to deeply grasp the essence of TCM and improve the comprehensive quality of talents.(6)The hospital keeps on the leading role of international communication,advancing the international exchange and cooperation of acupuncture and moxibustion,and contributes more eastern wisdom to global health governance,and promote acupuncture and moxibustion of TCM,the treasure of the Chinese nation to display its importance in the world.
基金supported by the Zhejiang Science and Technology Program of TCM(No.2025ZF017)the Clinical Young-Talent Trainning Project in TCM under the Young Eagle Program of the China Association of Chinese Medicine(No.CYJH2024048).
文摘This study summarizes the clinical experience of professor LIAN Jianwei, a nationally renowned traditional Chinese medicine (TCM) practitioner, in treating chronic atrophic gastritis (CAG) with syndrome differentiation based on pulse-taking. Professor LIAN emphasizes the importance of pulse diagnosis in TCM clinical practice, focusing on the normal and variant aspects of pulse methods, and centers on the dynamic changes of the “Guan pulse” to accurately determine the functional status of the spleen and stomach based on pulse variations, thereby formulating personalized treatment plans. For patients with a slow and moderate pulse, spleen and stomach deficiency and dampness due to spleen deficiency are often identified, and treatment mainly focuses on strengthening the spleen, resolving dampness, and boosting Qi to aid transportation, usually with modifications of Shenling Baizhu San. When the left Guan pulse is string-like and the right Guan pulse is slow and moderate, it indicates liver depression and spleen deficiency, and Xiaoyao San is commonly used to soothe the liver, nourish the blood, and strengthen the spleen, harmonizing the liver and spleen. If the right Guan pulse is large and the left Guan pulse is string-like, it mostly belongs to liver and stomach Qi stagnation, and Bupleurum Liver-soothing powder is often used to soothe the liver, regulate Qi, and harmonize the stomach. A large and empty right Guan pulse suggests insufficiency of Central Qi, and Buzhong Yiqi Tang is commonly used to tonify Qi and soothe the liver. In terms of medication, professor LIAN pays attention to patients’ dietary habits and combines methods of eliminating dampness, promoting digestion, and activating blood circulation to improve symptoms and reverse atrophy.
基金supported by a grant from the National Basic Research Program (973 Program, No.2010CB530601)
文摘Objective: To observe the therapeutic effect of different dosages of Gegen Qin Lian Decoction (葛根芩连汤) on type 2 diabetic patients. Methods: Fifty-four type 2 diabetic patients from low dosage group (20 cases), medium dosage group (19 cases) and high dosage group (15 cases) were treated with different dosage of Gegen Qin Lian Decoction for 12 weeks. Fasting blood-glucose (FBG), postprandial blood sugar (PBG) and Hemoglobin A1c (HbAlc) were determined before and after treatment. Results: With the increase of dosage, the overall effective rate of glycaemic control increased, and FBG, PBG, HbAlc decreased. The overall effective rate of blood glucose control of high dosage, medium dosage and low dosage group were 80%, 47%, 30% respectively, and there were significant differences between high dosage group and low dosage group. The decrease of FBG, PBG and HbAlc of high dosage showed significant differences from low dosage too. These data was analyzed by trend χ2 test and covariance analysis. Conclusion: The result indicated that different dosage of Gegen Qin Lian Decoction has dose-effect relationship in reducing HbAlc and FBG.
基金supported by the Research and Development Projects of Application of Technology of Heilongjiang Province in China(No.GC13C109)Major Projects of Science and Technology "Significant Drug Discovery"-Transformation of SHL Powder for Injection,(China)(No.2011ZX09201-201-15)Science and Technology Projects on Heilongjiang Province of traditional Chinese Medicine(China)(No.ZHY16-099)
文摘Shuang-huang-lian Injection(SHLI) is the first successfully developed drug from traditional Chinese medicine(TCM) powder for injection,since its use for the treatment of acute respiratory tract infection,pneumonia,influenza,etc.At the same time,its allergic reactions have also emerged,which limits clinical applications.However,few scholars pay attention to the mechanism of allergic reactions.In this present study,metabonomics technology was used to explore the changes in endogenous metabolites in urine of the rat model of SHLI induced allergic reaction;we and analyzed the metabolites,metabolic pathway,and the mechanism which were closely related to the allergic reactions.The levels of serum histamine and tryptase were examined and changes in histomorphology were also observed.Based on the UPLC-Q-TOF/MS metabonomics,we carried out the pattern recognition analysis,selected potential biomarkers associated with allergic reactions,and explored the pathological mechanism for SHLI induced allergic reaction,which laid the foundation for the safety research of SHLI.Our results showed that SHLI increased the levels of serum histamine and tryptase in rats with allergic reaction;we determined 15 biomarkers in rat allergic reaction model induced by SHLI and found multiple metabolic pathways involved,such as metabolism of linolenic acid,phenylalanine,amino acid,2-oxo acid,and purine and other metabolic pathways.
文摘With the advantages of less toxicity and side effects, traditional Chinese medicine(TCM) is showing a bright future with a good clinical practice. Chinese herbal medicine, which usually contains various active ingredients, could provide multiple therapeutic effects. Professor Tong Xiaolin has accumulated abundant experience during many years of clinical practice and applies Rhizoma Coptidis(RC) well with the treatment of diabetes and its complications. Rhizoma coptidis is a classical natural herb which is used frequently by professor Tong Xiaolin. In this review, we summarize Tong Xiaolin's clinical experience of applying Rhizoma Coptidis(Huang Lian) in the treatment of disease from two aspects as well as introducing some traditional Chinese medical theory and clinical experience, with a prospect of guiding clinician to use RC more suitably and reasonably.
基金supported by National Natural Science Foundation of China(8137344181673464)
文摘OBJECTIVE To explore the anti-atherosclerotic effect of the extract of traditional Chinese medicine formula Dan-yi-lian(DYL) and the related mechanism.METHODS Atherosclerosis(AS) mod.el was established in ApoE(-/-) mice with a western diet.The mice were orally administered with differ.ent doses of DYL or vehicle daily for 28 d.The anti-atherosclerotic effect was evaluated by measuring the aortic atherosclerotic lesion area and media thickness with ultrasound imaging and histological sec.tions staining method.The effect on blood lipid was investigated by determining TC,TG,LDL,HDL,Apo-A1,Apo-B,etc.The anti-oxidative activity as assessed by determining the level of SOD,CAT,GSH,GSH-Px and MDA.Western blot analysis was used to determine the effect on ICAM-1,VCAM-1,MMP-2 and TNF-α.RESULTS In Dan-yi-lian administered ApoE(-/-) mice,the plaque area and media thickness were significantly reduced.Meanwhile,serum TC,TG,LDL and Apo-B were decreased,in contrast to the increased level of HDL and Apo-A1.On the other hand,SOD,CAT,GSH and GSH-Px were increased,while MDA was reduced in liver homogenate.In addition,the expression of ICAM-1,VCAM-1,MMP-2 and TNF-α was obviously inhibited by Dan-yi-lian.CONCLUSION Dan-yi-lian exhibit.ed potent anti-athero-sclerotic efficacy,in which the lipid-regulating,anti-oxidative and anti-inflammato.ry mechanism might be involved.
文摘Objective： To observe the clinical effects of Zhu Lian＇s type Ⅰ excitation needling technique for postpartum urinary retention.Methods： A total of 60 cases with postpartum urinary retention were recruited and divided randomly into an observation group and a control group, 30 cases in each group. The control group was treated with routine acupuncture, and stimulated with sparse and dense wave of electric acupuncture for 15 min after arrival of needling sensation, and then the needles were taken out. The observation group was treated with Zhu Lian＇s type Ⅰ excitation needling technique, by inserting the needles with the quick inserting method, swift and temporary lifting and thrusting technique for shallow insertion for 5times, by an in-and-out technique, without retaining the needles.Results： The total effective rate was 96.7% in the observation group and 83.3% in the control group. The difference in the total effective rate between the two groups was statistically significant（P〈0.05）. After the treatment, the first urination time was shorter in the observation group than that in the control group, with a statistical significance（P〈0.01）. After the treatment, the volume of residual urine after the first urination was less in the observation group than that in the control group（P〈0.01）.Conclusion： Zhu Lian＇s type Ⅰ excitation needling technique can effectively promote the voluntary urination and bladder emptying in patients with postpartum urinary retention, and it takes effect faster.
文摘Professor LIAN Yu-lin dedicates himself to the cause of TCM and acupuncture, and puts forward some original ideas on the basic theory of acupuncture.In clinical practice, he devotes himself to the study of some difficult and complicated illnesses in acupuncture,with excellent results.
文摘OUR plane flew through white clouds, taking us to Sichuan Province for a visit to Dharmacarya Long Lian, who is honored the No.1 bhiksuni in China. At 86, respected by domestic and overseas Buddhists, this eminent nun has had remarkable experiences. She is good at poetry and painting and of great attainments in Buddhism. She created the first bhiksuni Buddhist institute in China. After the plane landed in Chengdu, we took a taxi to the Tiexiang (Iron Statue) Monastery, a newly-renovated monastery beside lush green rice fields. A nun met us and led us into a shady courtyard in front
