The study aims to highlight the contribution of sport as a tool for preventing early school leaving and developing psychophysical well-being.School,territory and sports association can,with appropriate institutional p...The study aims to highlight the contribution of sport as a tool for preventing early school leaving and developing psychophysical well-being.School,territory and sports association can,with appropriate institutional partnership actions,implement training interventions in this sense.Through an analysis of the scientific literature we want to highlight the important value of sports practice especially in school age.Organized sports activities contribute to the development of skills related to socio-relational well-being.Full awareness of one’s own cognitive and social skills allows improving self-perception.Sport,therefore,becomes a tool for preventing and contrasting early school leaving,a real protective factor that limits the decrease in motivation to school attendance and favors school performance.展开更多
APRIL 27, 1994 is a day South Africans will never forget. It marked the first democratic elections, historically ending more than 300 years of colonial and white minority rule, It also heralded the election of Nelson ...APRIL 27, 1994 is a day South Africans will never forget. It marked the first democratic elections, historically ending more than 300 years of colonial and white minority rule, It also heralded the election of Nelson Mandela. an icon in the country＇s pursuit of freedom, as South Africa＇s president.展开更多
Introduction When interviewing a medical resident for a potential fellowship in Cardiovascular medicine,the majority of candidates indicate an interest in academic cardiology.However,few opt for an academic career and...Introduction When interviewing a medical resident for a potential fellowship in Cardiovascular medicine,the majority of candidates indicate an interest in academic cardiology.However,few opt for an academic career and many decide during fellowship that private practice is best for them.I have no problem with that decision.The focus of this manuscript in on those who opt for an academic career and for several reasons decide,after a few years,to leave the academic program and often leave gaping holes in the multiple aspects of the program,that require attention of the chief of cardiology.展开更多
Background In a previously identified locus linked to hypertension on chromosome 15q, we identified three blood pressure candidate genes: insulin-like growth factor 1 receptor gene (IGF1R), myocyte specific enhancer f...Background In a previously identified locus linked to hypertension on chromosome 15q, we identified three blood pressure candidate genes: insulin-like growth factor 1 receptor gene (IGF1R), myocyte specific enhancer factor 2A gene (MEF2A), and paired basic amino acid cleaving enzyme 4 gene (PACE4). In this study, we te sted their associations with hypertension using haplotype analysis.Methods A total of 288 unrelated individuals, including 163 high diastolic blood pressure (DBP) subjects and 125 normal DBP subjects were enrolled in this case-control study. Twenty single nucleotide polymorphisms (SNPs) in the three genes were genotyped using polymerase chain reaction followed by restriction enzyme digestion. Haplotype analysis was accomplished in the following stages: (1) pair-wise linkage disequilibrium test among SNPs on the same gene was performed to explore blocks in which recombination is very unlikely to happen; (2) Estimation-Maximization algorithm was applied to estimate haplotype frequencies in each block; (3) the chi-square test was used to examine the specific haplotype difference, and a permutation test was used to examine the overall haplotype profile difference between cases and controls in each block.Results An estimated haplotype “CCCCG” frequency in the haplotype block on the PACE4 gene was significantly higher in high DBP cases than in controls (P<0.01). The overall estimated haplotype profile in this block was also significantly different between the cases and the controls (P<0 .001). This association indicates. Conclusions This study for the first time demonstrated that PAC E4 gene may play an important role in the regulation of DBP. This association indicates that variations influencing DBP resides in or near this genomic region.展开更多
With the progress of urbanization,rural tourism has emerged as a popular leisure activity in China.The crop field with pattern art has been gaining popularity over the years,using strains with colorful leaves to creat...With the progress of urbanization,rural tourism has emerged as a popular leisure activity in China.The crop field with pattern art has been gaining popularity over the years,using strains with colorful leaves to create various impressive designs(Xu 2024).A lot of successful cases in rice fields have not only attracted tourists but also increased the income of farmers(Song et al.2020).Plants with colorful leaves also have gained significant popularity in ornamental agriculture.Therefore,developing plants with colorful leaves has gained significant popularity in ornamental agriculture.展开更多
The Solanum genus is known for its diverse bioactive compounds,yet its diuretic potential remains understudied.This research commenced with an analysis of polyphenol and flavonoid content in Solanum elaeagnifolium lea...The Solanum genus is known for its diverse bioactive compounds,yet its diuretic potential remains understudied.This research commenced with an analysis of polyphenol and flavonoid content in Solanum elaeagnifolium leaf extract(SEFE)using colorimetric techniques,followed by HPLC-DAD to delineate its chemical composition.The aqueous extract revealed prominent constituents:naringin(12.38%),quercetin 3-O-B-D-Glucoside(27.25%),and flavone(15.26%).A 15-day study on normal rats investigated the diuretic potential of SEFE at repeated doses.SEFE significantly increased urine volume and urinary sodium/potassium levels without inducing hypokalaemia,contrasting with furosemide,a standard diuretic that induced hypokalaemia.Conversely,furosemide,a standard diuretic,increased urinary sodium and potassium while inducing hypokalaemia.It was evident that the diuretic effect of S.elaeagnifolium is dose-dependent,with a dosage of 500 mg/kg body weight exerting a more potent diuretic effect compared to furosemide.The diuretic activity of this plant was supported by an in silico study of the diuretic effect.The findings demonstrate how S.elaeagnifolium leaves have a potent diuretic impact on rats.However,more in-depth studies are needed to examine the following aspects:identifying the specific molecules responsible for the diuretic effect,understanding the molecular and cellular mechanisms underlying this activity,and assessing the long-term safety and clinical efficacy of this plant in different contexts.展开更多
As the warm breeze sweeps over the peaks of the Himalayas,spring air fills the vast Qinghai-Xizang Plateau.Residents of Metok County,Nyingchi City,Xizang,are welcoming the"harvest season"busy picking tender ...As the warm breeze sweeps over the peaks of the Himalayas,spring air fills the vast Qinghai-Xizang Plateau.Residents of Metok County,Nyingchi City,Xizang,are welcoming the"harvest season"busy picking tender tea leaves and loquats.展开更多
The potherb mustard Xuecai(XC)cultivar is a cruciferous vegetable that is popular either fresh or pickled.Due to the deep notches in the edges of leaves in mustard XC,this plant can be said to have multipinnately lobe...The potherb mustard Xuecai(XC)cultivar is a cruciferous vegetable that is popular either fresh or pickled.Due to the deep notches in the edges of leaves in mustard XC,this plant can be said to have multipinnately lobed leaves.The net photosynthesis of lobed leaves is significantly greater than that of simple leaves.However,the molecular mechanism of leaf shape variation has not been determined.Here,we used HiFi and Hi-C data to assemble the XC genome.The genome was 961.72 Mb in size,with a contig N50 value of 6.565 Mb.The XC genome was compared with four previously sequenced mustard genomes,and the genomic collinearity regions,SNPs,and indels were identified.Five BjRCO genes were found on chromosome(Chr.)A10 in potherb mustard XC when the BjRCO gene locus was compared against other sequenced B.juncea genomes.Segmental duplication was found to contribute to the BjRCO gene copy number.The transcript expression of BjRCO genes was greater in multipinnately lobed leaves than in sawtooth-like leaves.Together,these findings indicate that both the greater copy number and the expression level of BjRCO genes regulate leaf shape from simple to complex in B.juncea.Gene editing of the BjRCO gene from XC changed the leaf shape from multipinnately lobed to simple.The high-quality XC genome sequence not only provides new insight into B.juncea leaf-type genomics but also helps in deciphering leaf shape variation.Our study provides insights into the variation and evolution of important traits in Brassica plants through a comparative analysis of the sequenced genomes.展开更多
At the end of Oct.2024,Gyacha County basked under the warm sunlight.Standing within the nearly thousand-year-old renowned walnut forest,the azure sky,accompanied by drifting white clouds,appeared particularly captivat...At the end of Oct.2024,Gyacha County basked under the warm sunlight.Standing within the nearly thousand-year-old renowned walnut forest,the azure sky,accompanied by drifting white clouds,appeared particularly captivating.The occasional thud of walnuts striking the earth heralded the continuation of life into a new generation,while the golden leaves whispered of the gradual departure of the old.展开更多
Laser-Induced Graphene (LIG) is regarded as a promising sensor carrier due to its inherent three-dimensional porous structure. However, as two mutually exclusive properties of the pressure sensor, sensitivity and work...Laser-Induced Graphene (LIG) is regarded as a promising sensor carrier due to its inherent three-dimensional porous structure. However, as two mutually exclusive properties of the pressure sensor, sensitivity and working range are difficult to be further improved by the single porous structure. Inspired by the unique geometry of Oxalis corniculata L. leaves, we here propose a novel method consist of laser pre-etching and inducing steps to fabricate LIG-based electrodes with a two-stage architecture featuring microjigsaw and microporous structures. The following injection of liquid-silicone significantly improves the friction resistance and bending reliability of LIG materials. The interface contact between external microjigsaw structures induces substantial resistance changes, and the internal microporous structure exhibits reversibility during dynamic deformation. Consequently, the jigsaw-like pressure sensor achieves a balanced performance with sensitivities of 3.64, 1.20 and 0.03 kPa^(- 1) in pressure range of 0 -20, 20 - 40 and 40 - 150 kPa, respectively. The bionic LIG-based pressure sensor serves as the core component and further integrated with an all-in-one wireless transmission system capable of monitoring various health parameters such as subtle pulse rates, heartbeat rhythms, sounds, etc., indicating broad prospects in future wearable electronics.展开更多
BACKGROUND Upper respiratory tract infections(URTIs)are one of the most frequent causes of childhood school leave and morbidity.AIM To study the present trend of medications’prescribing pattern utilized in URTIs amon...BACKGROUND Upper respiratory tract infections(URTIs)are one of the most frequent causes of childhood school leave and morbidity.AIM To study the present trend of medications’prescribing pattern utilized in URTIs among the pediatric population attending outpatient clinics in pediatric hospitals.METHODS This analytical observational cross-sectional research was conducted in 200 children aged 1–10 years with URTIs attending the pediatric outpatient clinics in pediatric hospitals,one of which is an educational hospital,from July 2018 to August 2020.RESULTS Most of the prescriptions in our study included antibiotics(116/58%).The most commonly prescribed antibiotic family was ampicillin/sulbactam or amoxici-llin/clavulanic acid(53/26.5%),followed by first-generation cephalosporin(25/12.5%)and third-generation cephalosporin(20/10%).Macrolides and second-generation cephalosporins were prescribed less frequently,in 16(8%)and 2(1%)patients,respectively.Most of our study population(155/77.5%)was satisfied with their prescriptions,whereas the rest of the study population(45/22.5%)was unsatisfied.CONCLUSION Overprescription of antibiotics is a significant issue among clinicians in pediatric outpatient clinics.Stewardship of drugs,particularly antibiotics,is a must to prevent the development of drug resistance.Most cases of URTIs were treated in accordance with the existing national treatment guidelines.展开更多
The aromatic Baeckea frutescens leaves(BFL)known as“Gang-Song-Cha”is a popular drink(Tea)in South China.To explore the healthcare value,a systematic and in-depth study on BFL alleviating rheumatoid arthritis(RA)was ...The aromatic Baeckea frutescens leaves(BFL)known as“Gang-Song-Cha”is a popular drink(Tea)in South China.To explore the healthcare value,a systematic and in-depth study on BFL alleviating rheumatoid arthritis(RA)was carried out by integrating network pharmacology,molecular docking,and experimental verification.The efficacy was first evaluated,and the BFL extract could ameliorate RA by inhibiting articular swelling,lowering immune organ index,improving the ankle pathologies,and regulating serum levels of tumor necrosis factorα(TNF-α),interleukin(IL)-6,and IL-10 in CIA rats.Then the anti-RA mechanism of BFL was investigated by leveraging the high-content and active component 5-hydroxy-7-methoxy-2-isopropylchromone(Chro),and the potential signaling pathway and related target proteins for Chro acting on RA were analyzed by Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment and docking simulation.Finally,the experimental validations were conducted on rheumatoid arthritis fibroblast-like synoviocytes(RAFLS),and compound Chro could inhibit cell invasion and migration,block cell cycle at G2/M phase and induce apoptosis,and reduce the secretion of inflammatory cytokines by suppressing the PI3K-Akt pathway.These results provided pharmacological basis for the folk usage of“Gang-Song-Cha”for intervening RA.展开更多
It has been three years since the war in Iraq began, but the situation in the country, especially the security, has not improved much. Meanwhile, the world is wondering when U.S. troops will leave, and the American pu...It has been three years since the war in Iraq began, but the situation in the country, especially the security, has not improved much. Meanwhile, the world is wondering when U.S. troops will leave, and the American public appears to be getting impatient with the seemingly endless casualty reports. Some groups have展开更多
A number of impressive and relaxing tourist attractions make northeast Hebei a worthwhile trip outside Beijing When it comes to culture and tourism,Hebei Province can’t compete with the imperial palaces,temples,summe...A number of impressive and relaxing tourist attractions make northeast Hebei a worthwhile trip outside Beijing When it comes to culture and tourism,Hebei Province can’t compete with the imperial palaces,temples,summer resorts and other ancient landmarks of Beijing.The province is also missing them useums and monuments to the people’s heroes.But what it lacks in epic tourist attractions Hebei makes up for with smaller,quainter sights that provide a pleasant respite from the busy city life and crowded tourist hotspots of the Chinese capital.展开更多
It's November,that time of the year when high school students have to slap oil their thinking caps and decide where they're going to spread their wings in terms of further education.After all,exam season is ju...It's November,that time of the year when high school students have to slap oil their thinking caps and decide where they're going to spread their wings in terms of further education.After all,exam season is just half a year away.The horror!Worrying about the best path to university is inevitable.展开更多
With the Chinese Government deciding to build a reservoir at Ibc Three Gorges in the Changjiang River, which is believed to be one of the best sources of water power in the world, residents living in that area have be...With the Chinese Government deciding to build a reservoir at Ibc Three Gorges in the Changjiang River, which is believed to be one of the best sources of water power in the world, residents living in that area have been asked to move. The orderly migration of local residents is a great concern of the Central Government and is being展开更多
美国西雅图Highline Community College的教授 Rosemary Adang不远万里,来到上海交大外国语学院英语系执教。一年光阴,短若一瞬！动身回国之前,她写下了以下激情澎湃的文字。本刊打算为她开辟一个新的专栏,专栏的标题是:美国教授眼中的...美国西雅图Highline Community College的教授 Rosemary Adang不远万里,来到上海交大外国语学院英语系执教。一年光阴,短若一瞬！动身回国之前,她写下了以下激情澎湃的文字。本刊打算为她开辟一个新的专栏,专栏的标题是:美国教授眼中的中国。这篇告别文字便成了这个新辟栏目的首篇。在以后的栏目中,我们可以看到,一个美国教授在中国感受到的或强或弱的文化冲突,在一年校园生活和社会中所经历的喜怒哀乐,在十多个风景如画的中国城市的旅行观感,对充满智慧和热情的上海人独到的认识,对中国琳琅多彩的商品和派系纷呈的佳肴的感慨,对中美消费品的物价自然而然作出的比较,等等。Rosemary敏锐的感受、精彩的文笔将有助于中美的文化交流,同时,读者也可学习到贴近生活的地道英语表达。读者对Rosemary Adang有什么问题想问,请写信和本刊编辑部联系,提问部分最好用英语写。展开更多
文摘The study aims to highlight the contribution of sport as a tool for preventing early school leaving and developing psychophysical well-being.School,territory and sports association can,with appropriate institutional partnership actions,implement training interventions in this sense.Through an analysis of the scientific literature we want to highlight the important value of sports practice especially in school age.Organized sports activities contribute to the development of skills related to socio-relational well-being.Full awareness of one’s own cognitive and social skills allows improving self-perception.Sport,therefore,becomes a tool for preventing and contrasting early school leaving,a real protective factor that limits the decrease in motivation to school attendance and favors school performance.
文摘APRIL 27, 1994 is a day South Africans will never forget. It marked the first democratic elections, historically ending more than 300 years of colonial and white minority rule, It also heralded the election of Nelson Mandela. an icon in the country＇s pursuit of freedom, as South Africa＇s president.
文摘Introduction When interviewing a medical resident for a potential fellowship in Cardiovascular medicine,the majority of candidates indicate an interest in academic cardiology.However,few opt for an academic career and many decide during fellowship that private practice is best for them.I have no problem with that decision.The focus of this manuscript in on those who opt for an academic career and for several reasons decide,after a few years,to leave the academic program and often leave gaping holes in the multiple aspects of the program,that require attention of the chief of cardiology.
文摘Background In a previously identified locus linked to hypertension on chromosome 15q, we identified three blood pressure candidate genes: insulin-like growth factor 1 receptor gene (IGF1R), myocyte specific enhancer factor 2A gene (MEF2A), and paired basic amino acid cleaving enzyme 4 gene (PACE4). In this study, we te sted their associations with hypertension using haplotype analysis.Methods A total of 288 unrelated individuals, including 163 high diastolic blood pressure (DBP) subjects and 125 normal DBP subjects were enrolled in this case-control study. Twenty single nucleotide polymorphisms (SNPs) in the three genes were genotyped using polymerase chain reaction followed by restriction enzyme digestion. Haplotype analysis was accomplished in the following stages: (1) pair-wise linkage disequilibrium test among SNPs on the same gene was performed to explore blocks in which recombination is very unlikely to happen; (2) Estimation-Maximization algorithm was applied to estimate haplotype frequencies in each block; (3) the chi-square test was used to examine the specific haplotype difference, and a permutation test was used to examine the overall haplotype profile difference between cases and controls in each block.Results An estimated haplotype “CCCCG” frequency in the haplotype block on the PACE4 gene was significantly higher in high DBP cases than in controls (P<0.01). The overall estimated haplotype profile in this block was also significantly different between the cases and the controls (P<0 .001). This association indicates. Conclusions This study for the first time demonstrated that PAC E4 gene may play an important role in the regulation of DBP. This association indicates that variations influencing DBP resides in or near this genomic region.
基金supported by the Guangdong Provincial Key Research and Development Program-Modern Seed Industry,China(2022B0202060004)the Knowledge Innovation Program of Wuhan-Basic Research,China(2022020801010291)+1 种基金the Project of the Development for High-quality Seed Industry of Hubei Province,China(HBZY2023B003)the Innovation Program of the Chinese Academy of Agricultural Sciences(2023-2060299-089-031)。
文摘With the progress of urbanization,rural tourism has emerged as a popular leisure activity in China.The crop field with pattern art has been gaining popularity over the years,using strains with colorful leaves to create various impressive designs(Xu 2024).A lot of successful cases in rice fields have not only attracted tourists but also increased the income of farmers(Song et al.2020).Plants with colorful leaves also have gained significant popularity in ornamental agriculture.Therefore,developing plants with colorful leaves has gained significant popularity in ornamental agriculture.
文摘The Solanum genus is known for its diverse bioactive compounds,yet its diuretic potential remains understudied.This research commenced with an analysis of polyphenol and flavonoid content in Solanum elaeagnifolium leaf extract(SEFE)using colorimetric techniques,followed by HPLC-DAD to delineate its chemical composition.The aqueous extract revealed prominent constituents:naringin(12.38%),quercetin 3-O-B-D-Glucoside(27.25%),and flavone(15.26%).A 15-day study on normal rats investigated the diuretic potential of SEFE at repeated doses.SEFE significantly increased urine volume and urinary sodium/potassium levels without inducing hypokalaemia,contrasting with furosemide,a standard diuretic that induced hypokalaemia.Conversely,furosemide,a standard diuretic,increased urinary sodium and potassium while inducing hypokalaemia.It was evident that the diuretic effect of S.elaeagnifolium is dose-dependent,with a dosage of 500 mg/kg body weight exerting a more potent diuretic effect compared to furosemide.The diuretic activity of this plant was supported by an in silico study of the diuretic effect.The findings demonstrate how S.elaeagnifolium leaves have a potent diuretic impact on rats.However,more in-depth studies are needed to examine the following aspects:identifying the specific molecules responsible for the diuretic effect,understanding the molecular and cellular mechanisms underlying this activity,and assessing the long-term safety and clinical efficacy of this plant in different contexts.
文摘As the warm breeze sweeps over the peaks of the Himalayas,spring air fills the vast Qinghai-Xizang Plateau.Residents of Metok County,Nyingchi City,Xizang,are welcoming the"harvest season"busy picking tender tea leaves and loquats.
基金supported by grants from the National Natural Science Foundation of China(32002056)the Science and Technology Research Key Project of Henan Province,China(242102111138)。
文摘The potherb mustard Xuecai(XC)cultivar is a cruciferous vegetable that is popular either fresh or pickled.Due to the deep notches in the edges of leaves in mustard XC,this plant can be said to have multipinnately lobed leaves.The net photosynthesis of lobed leaves is significantly greater than that of simple leaves.However,the molecular mechanism of leaf shape variation has not been determined.Here,we used HiFi and Hi-C data to assemble the XC genome.The genome was 961.72 Mb in size,with a contig N50 value of 6.565 Mb.The XC genome was compared with four previously sequenced mustard genomes,and the genomic collinearity regions,SNPs,and indels were identified.Five BjRCO genes were found on chromosome(Chr.)A10 in potherb mustard XC when the BjRCO gene locus was compared against other sequenced B.juncea genomes.Segmental duplication was found to contribute to the BjRCO gene copy number.The transcript expression of BjRCO genes was greater in multipinnately lobed leaves than in sawtooth-like leaves.Together,these findings indicate that both the greater copy number and the expression level of BjRCO genes regulate leaf shape from simple to complex in B.juncea.Gene editing of the BjRCO gene from XC changed the leaf shape from multipinnately lobed to simple.The high-quality XC genome sequence not only provides new insight into B.juncea leaf-type genomics but also helps in deciphering leaf shape variation.Our study provides insights into the variation and evolution of important traits in Brassica plants through a comparative analysis of the sequenced genomes.
文摘At the end of Oct.2024,Gyacha County basked under the warm sunlight.Standing within the nearly thousand-year-old renowned walnut forest,the azure sky,accompanied by drifting white clouds,appeared particularly captivating.The occasional thud of walnuts striking the earth heralded the continuation of life into a new generation,while the golden leaves whispered of the gradual departure of the old.
基金supported by the Natural Science Foundation of Hunan Province,China(No.2024JJ6039).
文摘Laser-Induced Graphene (LIG) is regarded as a promising sensor carrier due to its inherent three-dimensional porous structure. However, as two mutually exclusive properties of the pressure sensor, sensitivity and working range are difficult to be further improved by the single porous structure. Inspired by the unique geometry of Oxalis corniculata L. leaves, we here propose a novel method consist of laser pre-etching and inducing steps to fabricate LIG-based electrodes with a two-stage architecture featuring microjigsaw and microporous structures. The following injection of liquid-silicone significantly improves the friction resistance and bending reliability of LIG materials. The interface contact between external microjigsaw structures induces substantial resistance changes, and the internal microporous structure exhibits reversibility during dynamic deformation. Consequently, the jigsaw-like pressure sensor achieves a balanced performance with sensitivities of 3.64, 1.20 and 0.03 kPa^(- 1) in pressure range of 0 -20, 20 - 40 and 40 - 150 kPa, respectively. The bionic LIG-based pressure sensor serves as the core component and further integrated with an all-in-one wireless transmission system capable of monitoring various health parameters such as subtle pulse rates, heartbeat rhythms, sounds, etc., indicating broad prospects in future wearable electronics.
文摘BACKGROUND Upper respiratory tract infections(URTIs)are one of the most frequent causes of childhood school leave and morbidity.AIM To study the present trend of medications’prescribing pattern utilized in URTIs among the pediatric population attending outpatient clinics in pediatric hospitals.METHODS This analytical observational cross-sectional research was conducted in 200 children aged 1–10 years with URTIs attending the pediatric outpatient clinics in pediatric hospitals,one of which is an educational hospital,from July 2018 to August 2020.RESULTS Most of the prescriptions in our study included antibiotics(116/58%).The most commonly prescribed antibiotic family was ampicillin/sulbactam or amoxici-llin/clavulanic acid(53/26.5%),followed by first-generation cephalosporin(25/12.5%)and third-generation cephalosporin(20/10%).Macrolides and second-generation cephalosporins were prescribed less frequently,in 16(8%)and 2(1%)patients,respectively.Most of our study population(155/77.5%)was satisfied with their prescriptions,whereas the rest of the study population(45/22.5%)was unsatisfied.CONCLUSION Overprescription of antibiotics is a significant issue among clinicians in pediatric outpatient clinics.Stewardship of drugs,particularly antibiotics,is a must to prevent the development of drug resistance.Most cases of URTIs were treated in accordance with the existing national treatment guidelines.
基金supported by the National Natural Science Foundation of China(U1804182)the Basic Research(Natural Science)Cultivation Project of Zhengzhou University(JC23852095).
文摘The aromatic Baeckea frutescens leaves(BFL)known as“Gang-Song-Cha”is a popular drink(Tea)in South China.To explore the healthcare value,a systematic and in-depth study on BFL alleviating rheumatoid arthritis(RA)was carried out by integrating network pharmacology,molecular docking,and experimental verification.The efficacy was first evaluated,and the BFL extract could ameliorate RA by inhibiting articular swelling,lowering immune organ index,improving the ankle pathologies,and regulating serum levels of tumor necrosis factorα(TNF-α),interleukin(IL)-6,and IL-10 in CIA rats.Then the anti-RA mechanism of BFL was investigated by leveraging the high-content and active component 5-hydroxy-7-methoxy-2-isopropylchromone(Chro),and the potential signaling pathway and related target proteins for Chro acting on RA were analyzed by Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment and docking simulation.Finally,the experimental validations were conducted on rheumatoid arthritis fibroblast-like synoviocytes(RAFLS),and compound Chro could inhibit cell invasion and migration,block cell cycle at G2/M phase and induce apoptosis,and reduce the secretion of inflammatory cytokines by suppressing the PI3K-Akt pathway.These results provided pharmacological basis for the folk usage of“Gang-Song-Cha”for intervening RA.
文摘It has been three years since the war in Iraq began, but the situation in the country, especially the security, has not improved much. Meanwhile, the world is wondering when U.S. troops will leave, and the American public appears to be getting impatient with the seemingly endless casualty reports. Some groups have
文摘A number of impressive and relaxing tourist attractions make northeast Hebei a worthwhile trip outside Beijing When it comes to culture and tourism,Hebei Province can’t compete with the imperial palaces,temples,summer resorts and other ancient landmarks of Beijing.The province is also missing them useums and monuments to the people’s heroes.But what it lacks in epic tourist attractions Hebei makes up for with smaller,quainter sights that provide a pleasant respite from the busy city life and crowded tourist hotspots of the Chinese capital.
文摘It's November,that time of the year when high school students have to slap oil their thinking caps and decide where they're going to spread their wings in terms of further education.After all,exam season is just half a year away.The horror!Worrying about the best path to university is inevitable.
文摘With the Chinese Government deciding to build a reservoir at Ibc Three Gorges in the Changjiang River, which is believed to be one of the best sources of water power in the world, residents living in that area have been asked to move. The orderly migration of local residents is a great concern of the Central Government and is being
