飞机噪声评价方法的多元化反映了机场噪声问题的复杂性,我国采用计权等效连续感觉噪声级L_(WECPN),而国际上广泛采用昼夜等效声级L_(dn)。我国建筑室内噪声评价量采用的是等效声级L_(eq),与计权等效连续感觉噪声级难以横向比较。为了解...飞机噪声评价方法的多元化反映了机场噪声问题的复杂性,我国采用计权等效连续感觉噪声级L_(WECPN),而国际上广泛采用昼夜等效声级L_(dn)。我国建筑室内噪声评价量采用的是等效声级L_(eq),与计权等效连续感觉噪声级难以横向比较。为了解决机场噪声影响区的噪声治理适用标准问题,首先对L_(WECPN)、L_(dn)和L_(eq)三者的内涵进行分析,通过实测数据分析L_(WECPN)与另两个评价量之间的关系,证明L_(WECPN)与L_(dn)之间在数值上存在13 d B的差距,给出L_(WECPN)与相应的昼间和夜间等效声级L_(eq)上限值的对应关系,并分析背景噪声对评价量的影响。展开更多
Achieving land degradation neutrality(LDN)worldwide is a significant target of the Sustainable Development Goal(SDG15.3).Inner Mongolia,as a typical dryland region in northern China,has carried out several large-scale...Achieving land degradation neutrality(LDN)worldwide is a significant target of the Sustainable Development Goal(SDG15.3).Inner Mongolia,as a typical dryland region in northern China,has carried out several large-scale ecological restoration programs to combat land degradation.However,there is a lack of comprehensive assess-ment of its land degradation situation after ecological programs implementation,which is of great significance to supporting SDG15.3 in China.This study analyzed the land degradation situation using the improved SDG15.3.1 calculation framework based on fine resolution data in Inner Mongolia from 2000 to 2020,and finally compre-hensively evaluated the land status of the whole region and those subject to ecological programs.The results show that net land restoration proportion of various ecological project regions and whole region continues to increase.The scope of the Grain for Green Program(GGP)had the largest proportion of net land restoration while the Natural Reserve Program(NRP)had the lowest proportion from 2000 to 2020.The net land restoration area of Inner Mongolia during 2000-2010 and 2010-2020 was 35,800 km 2 and 65,300 km 2,respectively.Overall,Inner Mongolia has achieved statistically zero growth in land degradation under the governance of ecological restora-tion programs.Therefore,reasonable planning,well monitoring,and timely assessment of ecological restoration programs are crucial to support SDG15.3.展开更多
Chronic pain is a multifaceted debilitating experience often associated with significant physical and emotional burden. Low dose naltrexone (LDN) has gained attention in recent years for its potential utility in the m...Chronic pain is a multifaceted debilitating experience often associated with significant physical and emotional burden. Low dose naltrexone (LDN) has gained attention in recent years for its potential utility in the management of fibromyalgia, irritable bowel syndrome, multiple sclerosis, and painful diabetic neuropathy. LDN’s analgesic effects have been associated with its ability to increase the production of endorphins while reducing the production of tumor necrosis factor-alpha, interleukin-6, reactive oxygen species and nitric oxide. This meta-analysis aims to systematically review and synthesize the available evidence on efficacy of LDN as an analgesic in pain syndromes, with a focus on chronic (neuro) inflammatory diseases. The goal is to provide clinicians with a more comprehensive estimate of the effectiveness of LDN as a non-opioid option for managing chronic pain and guide future research in the area. Thirteen randomized control trials, published from 1990 to 2022, were selected for the analysis that satisfied inclusion criteria. The overall effects in these studies were calculated using the standardized mean difference (SMD) between the LDN and placebo groups. We found an overall SMD of -10.77 (95% CI: -13.96 to -7.58) with a p-value of 0.002. This indicated that the LDN group experienced a statistically significant reduction in pain compared to placebo. This meta-analysis provides evidence for the potential efficacy of low dose naltrexone in reducing pain and enhancing analgesia in various pain syndromes. LDN may be a useful treatment option for patients suffering from chronic pain, particularly with fibromyalgia, multiple sclerosis, or diabetic neuropathy. However, further research is needed to confirm the efficacy and safety of low dose naltrexone for chronic pain conditions, especially with larger sample sizes, standardized dosing regimens and treatment durations.展开更多
Allogeneic hematopoietic stem cell transplantation(alloHSCT)is a life-saving procedure used for the treatment of selected hematological malignancies,inborn errors of metabolism,and bone marrow failures.The role of neu...Allogeneic hematopoietic stem cell transplantation(alloHSCT)is a life-saving procedure used for the treatment of selected hematological malignancies,inborn errors of metabolism,and bone marrow failures.The role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against infection.However,recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered functions.Accordingly,neutrophils are emerging as highly versatile cells that are able to acquire different,often opposite,functional capacities depending on the microenvironment and their differentiation status.Herein,we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT,from the hematopoietic stem cell(HSC)mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC infusion.We also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versushost disease(GVHD)prophylaxis.Finally,the potential involvement of neutrophils in alloHSCT-related complications,such as transplant-associated thrombotic microangiopathy(TA-TMA),acute and chronic GVHD,and cytomegalovirus(CMV)reactivation,is also discussed.Based on the data reviewed herein,the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial role.However,much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT.展开更多
Desertification has been caused by various factors and is a major environmental problem and development bottleneck faced by the world. It is also a serious threat to ecological security and to sustainable economic and...Desertification has been caused by various factors and is a major environmental problem and development bottleneck faced by the world. It is also a serious threat to ecological security and to sustainable economic and social development. As a stubborn world problem, focused on by the United Nations 2030 sustainable development goal 15.3, China aims to combat desertification by implementing the "eight-column fourbeam" strategy, and also suggest the "four-medicine"approach for global desertification governance. This includes the development of the United Nations Convention to Combat Desertification protocol, unified global compliance and compliance metrics; building a global observation network, and monitoring land changes based on remote sense; preparing the global natural desert(heritage) list, leaving the original deserts for future generations; initiating the global action of combating desertification, and striving to achieve a land degradationneutral world by 2030.展开更多
文摘飞机噪声评价方法的多元化反映了机场噪声问题的复杂性,我国采用计权等效连续感觉噪声级L_(WECPN),而国际上广泛采用昼夜等效声级L_(dn)。我国建筑室内噪声评价量采用的是等效声级L_(eq),与计权等效连续感觉噪声级难以横向比较。为了解决机场噪声影响区的噪声治理适用标准问题,首先对L_(WECPN)、L_(dn)和L_(eq)三者的内涵进行分析,通过实测数据分析L_(WECPN)与另两个评价量之间的关系,证明L_(WECPN)与L_(dn)之间在数值上存在13 d B的差距,给出L_(WECPN)与相应的昼间和夜间等效声级L_(eq)上限值的对应关系,并分析背景噪声对评价量的影响。
基金This work was supported by the National Natural Science Foundation of China(Grants No.41991232 and 42171318)and the Fundamental Research Funds for the Central Universities.
文摘Achieving land degradation neutrality(LDN)worldwide is a significant target of the Sustainable Development Goal(SDG15.3).Inner Mongolia,as a typical dryland region in northern China,has carried out several large-scale ecological restoration programs to combat land degradation.However,there is a lack of comprehensive assess-ment of its land degradation situation after ecological programs implementation,which is of great significance to supporting SDG15.3 in China.This study analyzed the land degradation situation using the improved SDG15.3.1 calculation framework based on fine resolution data in Inner Mongolia from 2000 to 2020,and finally compre-hensively evaluated the land status of the whole region and those subject to ecological programs.The results show that net land restoration proportion of various ecological project regions and whole region continues to increase.The scope of the Grain for Green Program(GGP)had the largest proportion of net land restoration while the Natural Reserve Program(NRP)had the lowest proportion from 2000 to 2020.The net land restoration area of Inner Mongolia during 2000-2010 and 2010-2020 was 35,800 km 2 and 65,300 km 2,respectively.Overall,Inner Mongolia has achieved statistically zero growth in land degradation under the governance of ecological restora-tion programs.Therefore,reasonable planning,well monitoring,and timely assessment of ecological restoration programs are crucial to support SDG15.3.
文摘Chronic pain is a multifaceted debilitating experience often associated with significant physical and emotional burden. Low dose naltrexone (LDN) has gained attention in recent years for its potential utility in the management of fibromyalgia, irritable bowel syndrome, multiple sclerosis, and painful diabetic neuropathy. LDN’s analgesic effects have been associated with its ability to increase the production of endorphins while reducing the production of tumor necrosis factor-alpha, interleukin-6, reactive oxygen species and nitric oxide. This meta-analysis aims to systematically review and synthesize the available evidence on efficacy of LDN as an analgesic in pain syndromes, with a focus on chronic (neuro) inflammatory diseases. The goal is to provide clinicians with a more comprehensive estimate of the effectiveness of LDN as a non-opioid option for managing chronic pain and guide future research in the area. Thirteen randomized control trials, published from 1990 to 2022, were selected for the analysis that satisfied inclusion criteria. The overall effects in these studies were calculated using the standardized mean difference (SMD) between the LDN and placebo groups. We found an overall SMD of -10.77 (95% CI: -13.96 to -7.58) with a p-value of 0.002. This indicated that the LDN group experienced a statistically significant reduction in pain compared to placebo. This meta-analysis provides evidence for the potential efficacy of low dose naltrexone in reducing pain and enhancing analgesia in various pain syndromes. LDN may be a useful treatment option for patients suffering from chronic pain, particularly with fibromyalgia, multiple sclerosis, or diabetic neuropathy. However, further research is needed to confirm the efficacy and safety of low dose naltrexone for chronic pain conditions, especially with larger sample sizes, standardized dosing regimens and treatment durations.
基金supported by grants from Associazione Italiana per la Ricerca sul Cancro(AIRC,IG-20339)Ministero delllstruzione,deirUniversitci e della Ricerca(MIUR-PRIN 20177J4E75_004)Fondazione Cariverona to MAC。
文摘Allogeneic hematopoietic stem cell transplantation(alloHSCT)is a life-saving procedure used for the treatment of selected hematological malignancies,inborn errors of metabolism,and bone marrow failures.The role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against infection.However,recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered functions.Accordingly,neutrophils are emerging as highly versatile cells that are able to acquire different,often opposite,functional capacities depending on the microenvironment and their differentiation status.Herein,we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT,from the hematopoietic stem cell(HSC)mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC infusion.We also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versushost disease(GVHD)prophylaxis.Finally,the potential involvement of neutrophils in alloHSCT-related complications,such as transplant-associated thrombotic microangiopathy(TA-TMA),acute and chronic GVHD,and cytomegalovirus(CMV)reactivation,is also discussed.Based on the data reviewed herein,the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial role.However,much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT.
基金part of an International Cooperation in Science and Technology project of the Ministry of Science and Technology(2015DFR31130)the National Natural Science Foundation of China(31600581)+1 种基金a Forestry Soft Science Research Project of the State Forestry Administration(2016-R22)Research on the Present,Problems and Countermeasures of UNCCD Implementation Mechanism Project of State Forestry Administration,and a Henan Provincial Cooperation Project(No.68)
文摘Desertification has been caused by various factors and is a major environmental problem and development bottleneck faced by the world. It is also a serious threat to ecological security and to sustainable economic and social development. As a stubborn world problem, focused on by the United Nations 2030 sustainable development goal 15.3, China aims to combat desertification by implementing the "eight-column fourbeam" strategy, and also suggest the "four-medicine"approach for global desertification governance. This includes the development of the United Nations Convention to Combat Desertification protocol, unified global compliance and compliance metrics; building a global observation network, and monitoring land changes based on remote sense; preparing the global natural desert(heritage) list, leaving the original deserts for future generations; initiating the global action of combating desertification, and striving to achieve a land degradationneutral world by 2030.
