目的对红花注射液进行化学成分分析及应用分子对接技术筛选红花注射液中过敏原成分。方法应用高效液相色谱-离子阱-飞行时间质谱高分辨质谱技术(high performance liquid chromatography-ion trap-time-of-flight high resolution mass ...目的对红花注射液进行化学成分分析及应用分子对接技术筛选红花注射液中过敏原成分。方法应用高效液相色谱-离子阱-飞行时间质谱高分辨质谱技术(high performance liquid chromatography-ion trap-time-of-flight high resolution mass spectrometry,HPLC-IT-TOF-MS)鉴定红花注射液中化学成分,应用分子对接技术进一步对潜在过敏原成分进行筛选。结果从红花注射液中共鉴定出40个化合物,其中26个查耳酮碳苷类化合物、8个黄酮类化合物、3个生物碱类化合物和3个其他类化合物,所有化合物均在负离子模式下鉴定。将这些化合物分别与人血清白蛋白(human serum albumin,HSA)、Mas相关G蛋白偶联受体X2(Mas-related G protein-coupled receptor X2,MRGPRX2)、Ras同源基因家族成员A(Ras homolog gene family member A)等蛋白进行分子对接,其中与HAS结合的化合物6个,与MRGPRX2结合的化合物有9个,发现红花注射液中过敏成分主要为6-羟基山柰酚类化合物和红花醌类化合物。结论建立了液-质联用与分子对接相结合的过敏原筛选方法,从红花注射液中鉴定出40个化合物,明确6-羟基山柰酚类和红花醌类化合物为潜在过敏原,为红花注射液过敏原筛选及其致敏机制研究提供了重要参考和数据。展开更多
With the expansion of peanut planting area year by year,film mulching cultivation has become increasingly important in peanut production due to its unique advantages in enhancing both yield per unit area and overall e...With the expansion of peanut planting area year by year,film mulching cultivation has become increasingly important in peanut production due to its unique advantages in enhancing both yield per unit area and overall economic benefits.Based on the varietal characteristics of‘Zhouhua 5’and addressing practical issues in peanut production,this paper summarized key techniques for high-yield and high-efficiency film mulching cultivation of this variety.These techniques cover all critical stages,including land preparation and fertilization,seed preparation,sowing methods,field management,and timely harvesting,providing technical guidance for varietal promotion and peanut production.展开更多
Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating th...Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.展开更多
Network-on-Chip(NoC)systems are progressively deployed in connecting massively parallel megacore systems in the new computing architecture.As a result,application mapping has become an important aspect of performance ...Network-on-Chip(NoC)systems are progressively deployed in connecting massively parallel megacore systems in the new computing architecture.As a result,application mapping has become an important aspect of performance and scalability,as current trends require the distribution of computation across network nodes/points.In this paper,we survey a large number of mapping and scheduling techniques designed for NoC architectures.This time,we concentrated on 3D systems.We take a systematic literature review approach to analyze existing methods across static,dynamic,hybrid,and machine-learning-based approaches,alongside preliminary AI-based dynamic models in recent works.We classify them into several main aspects covering power-aware mapping,fault tolerance,load-balancing,and adaptive for dynamic workloads.Also,we assess the efficacy of each method against performance parameters,such as latency,throughput,response time,and error rate.Key challenges,including energy efficiency,real-time adaptability,and reinforcement learning integration,are highlighted as well.To the best of our knowledge,this is one of the recent reviews that identifies both traditional and AI-based algorithms for mapping over a modern NoC,and opens research challenges.Finally,we provide directions for future work toward improved adaptability and scalability via lightweight learned models and hierarchical mapping frameworks.展开更多
With the increasing emphasis on personal information protection,encryption through security protocols has emerged as a critical requirement in data transmission and reception processes.Nevertheless,IoT ecosystems comp...With the increasing emphasis on personal information protection,encryption through security protocols has emerged as a critical requirement in data transmission and reception processes.Nevertheless,IoT ecosystems comprise heterogeneous networks where outdated systems coexist with the latest devices,spanning a range of devices from non-encrypted ones to fully encrypted ones.Given the limited visibility into payloads in this context,this study investigates AI-based attack detection methods that leverage encrypted traffic metadata,eliminating the need for decryption and minimizing system performance degradation—especially in light of these heterogeneous devices.Using the UNSW-NB15 and CICIoT-2023 dataset,encrypted and unencrypted traffic were categorized according to security protocol,and AI-based intrusion detection experiments were conducted for each traffic type based on metadata.To mitigate the problem of class imbalance,eight different data sampling techniques were applied.The effectiveness of these sampling techniques was then comparatively analyzed using two ensemble models and three Deep Learning(DL)models from various perspectives.The experimental results confirmed that metadata-based attack detection is feasible using only encrypted traffic.In the UNSW-NB15 dataset,the f1-score of encrypted traffic was approximately 0.98,which is 4.3%higher than that of unencrypted traffic(approximately 0.94).In addition,analysis of the encrypted traffic in the CICIoT-2023 dataset using the same method showed a significantly lower f1-score of roughly 0.43,indicating that the quality of the dataset and the preprocessing approach have a substantial impact on detection performance.Furthermore,when data sampling techniques were applied to encrypted traffic,the recall in the UNSWNB15(Encrypted)dataset improved by up to 23.0%,and in the CICIoT-2023(Encrypted)dataset by 20.26%,showing a similar level of improvement.Notably,in CICIoT-2023,f1-score and Receiver Operation Characteristic-Area Under the Curve(ROC-AUC)increased by 59.0%and 55.94%,respectively.These results suggest that data sampling can have a positive effect even in encrypted environments.However,the extent of the improvement may vary depending on data quality,model architecture,and sampling strategy.展开更多
This paper elaborates on the concept of Traditional Chinese Medicine(TCM)nursing appropriate techniques,selects techniques including moxibustion,auricular seed pressing,acupoint application,massage and Tuina,Chinese h...This paper elaborates on the concept of Traditional Chinese Medicine(TCM)nursing appropriate techniques,selects techniques including moxibustion,auricular seed pressing,acupoint application,massage and Tuina,Chinese herbal foot bath,five-tone therapy,and aromatherapy,and summarizes the application mechanisms,methods,and clinical effects of these techniques in patients with insomnia.It also analyzes the existing problems in their application and discusses future development and practice directions,aiming to provide references for establishing more standardized and scientific nursing plans for patients with insomnia.展开更多
Objective: To evaluate the preventive effect of shoulder dystocia midwifery techniques combined with predictive nursing on shoulder dystocia. Methods: A total of 82 high-risk pregnant women with shoulder dystocia admi...Objective: To evaluate the preventive effect of shoulder dystocia midwifery techniques combined with predictive nursing on shoulder dystocia. Methods: A total of 82 high-risk pregnant women with shoulder dystocia admitted for childbirth from January 2022 to January 2025 were selected and equally divided using a random number table. The experimental group received shoulder dystocia midwifery techniques combined with predictive nursing, while the reference group received routine midwifery care. Indicators such as the preventive effect on shoulder dystocia were compared between the two groups. Results: The incidence of shoulder dystocia in the experimental group was lower than that in the reference group, the duration of labor was shorter, the amount of intra-partum bleeding was less, the incidence of adverse delivery outcomes was lower, and the score for fear of childbirth after intervention was lower than that in the reference group (p < 0.05). Conclusion: Implementing shoulder dystocia midwifery techniques combined with predictive nursing for high-risk pregnant women with shoulder dystocia can prevent shoulder dystocia and other adverse delivery outcomes, shorten the duration of labor, reduce intra-partum bleeding, and alleviate pregnant women’s fear of childbirth, demonstrating high nursing value.展开更多
1.Introduction.Pancreaticoduodenectomy is an essential surgical procedure for the treatment of malignant tumors in the pancreatic head,distal common bile duct,and duodenal papilla,and is widely used in clinical practi...1.Introduction.Pancreaticoduodenectomy is an essential surgical procedure for the treatment of malignant tumors in the pancreatic head,distal common bile duct,and duodenal papilla,and is widely used in clinical practice.One of the primary determinants of surgical success is the durability of the pancreaticojejunal anastomosis.展开更多
文摘目的对红花注射液进行化学成分分析及应用分子对接技术筛选红花注射液中过敏原成分。方法应用高效液相色谱-离子阱-飞行时间质谱高分辨质谱技术(high performance liquid chromatography-ion trap-time-of-flight high resolution mass spectrometry,HPLC-IT-TOF-MS)鉴定红花注射液中化学成分,应用分子对接技术进一步对潜在过敏原成分进行筛选。结果从红花注射液中共鉴定出40个化合物,其中26个查耳酮碳苷类化合物、8个黄酮类化合物、3个生物碱类化合物和3个其他类化合物,所有化合物均在负离子模式下鉴定。将这些化合物分别与人血清白蛋白(human serum albumin,HSA)、Mas相关G蛋白偶联受体X2(Mas-related G protein-coupled receptor X2,MRGPRX2)、Ras同源基因家族成员A(Ras homolog gene family member A)等蛋白进行分子对接,其中与HAS结合的化合物6个,与MRGPRX2结合的化合物有9个,发现红花注射液中过敏成分主要为6-羟基山柰酚类化合物和红花醌类化合物。结论建立了液-质联用与分子对接相结合的过敏原筛选方法,从红花注射液中鉴定出40个化合物,明确6-羟基山柰酚类和红花醌类化合物为潜在过敏原,为红花注射液过敏原筛选及其致敏机制研究提供了重要参考和数据。
基金Supported by Zhoukou Key Science and Technology Research Project(20200816).
文摘With the expansion of peanut planting area year by year,film mulching cultivation has become increasingly important in peanut production due to its unique advantages in enhancing both yield per unit area and overall economic benefits.Based on the varietal characteristics of‘Zhouhua 5’and addressing practical issues in peanut production,this paper summarized key techniques for high-yield and high-efficiency film mulching cultivation of this variety.These techniques cover all critical stages,including land preparation and fertilization,seed preparation,sowing methods,field management,and timely harvesting,providing technical guidance for varietal promotion and peanut production.
基金supported by Healthy China initiative of Traditional Chinese Medicine(No.889042).
文摘Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.
基金the Deanship of Graduate Studies and Scientific Research at University of Bisha for supporting this work through the Fast-Track Research Support Programthe Deanship of Scientific Research at Northern Border University,Arar,KSA for funding this research work through the project number“NBU-FFR-2025-2903-09”.
文摘Network-on-Chip(NoC)systems are progressively deployed in connecting massively parallel megacore systems in the new computing architecture.As a result,application mapping has become an important aspect of performance and scalability,as current trends require the distribution of computation across network nodes/points.In this paper,we survey a large number of mapping and scheduling techniques designed for NoC architectures.This time,we concentrated on 3D systems.We take a systematic literature review approach to analyze existing methods across static,dynamic,hybrid,and machine-learning-based approaches,alongside preliminary AI-based dynamic models in recent works.We classify them into several main aspects covering power-aware mapping,fault tolerance,load-balancing,and adaptive for dynamic workloads.Also,we assess the efficacy of each method against performance parameters,such as latency,throughput,response time,and error rate.Key challenges,including energy efficiency,real-time adaptability,and reinforcement learning integration,are highlighted as well.To the best of our knowledge,this is one of the recent reviews that identifies both traditional and AI-based algorithms for mapping over a modern NoC,and opens research challenges.Finally,we provide directions for future work toward improved adaptability and scalability via lightweight learned models and hierarchical mapping frameworks.
基金supported by the Institute of Information&Communications Technology Planning&Evaluation(IITP)grant funded by the Korea government(MSIT)(No.RS-2023-00235509Development of security monitoring technology based network behavior against encrypted cyber threats in ICT convergence environment).
文摘With the increasing emphasis on personal information protection,encryption through security protocols has emerged as a critical requirement in data transmission and reception processes.Nevertheless,IoT ecosystems comprise heterogeneous networks where outdated systems coexist with the latest devices,spanning a range of devices from non-encrypted ones to fully encrypted ones.Given the limited visibility into payloads in this context,this study investigates AI-based attack detection methods that leverage encrypted traffic metadata,eliminating the need for decryption and minimizing system performance degradation—especially in light of these heterogeneous devices.Using the UNSW-NB15 and CICIoT-2023 dataset,encrypted and unencrypted traffic were categorized according to security protocol,and AI-based intrusion detection experiments were conducted for each traffic type based on metadata.To mitigate the problem of class imbalance,eight different data sampling techniques were applied.The effectiveness of these sampling techniques was then comparatively analyzed using two ensemble models and three Deep Learning(DL)models from various perspectives.The experimental results confirmed that metadata-based attack detection is feasible using only encrypted traffic.In the UNSW-NB15 dataset,the f1-score of encrypted traffic was approximately 0.98,which is 4.3%higher than that of unencrypted traffic(approximately 0.94).In addition,analysis of the encrypted traffic in the CICIoT-2023 dataset using the same method showed a significantly lower f1-score of roughly 0.43,indicating that the quality of the dataset and the preprocessing approach have a substantial impact on detection performance.Furthermore,when data sampling techniques were applied to encrypted traffic,the recall in the UNSWNB15(Encrypted)dataset improved by up to 23.0%,and in the CICIoT-2023(Encrypted)dataset by 20.26%,showing a similar level of improvement.Notably,in CICIoT-2023,f1-score and Receiver Operation Characteristic-Area Under the Curve(ROC-AUC)increased by 59.0%and 55.94%,respectively.These results suggest that data sampling can have a positive effect even in encrypted environments.However,the extent of the improvement may vary depending on data quality,model architecture,and sampling strategy.
文摘This paper elaborates on the concept of Traditional Chinese Medicine(TCM)nursing appropriate techniques,selects techniques including moxibustion,auricular seed pressing,acupoint application,massage and Tuina,Chinese herbal foot bath,five-tone therapy,and aromatherapy,and summarizes the application mechanisms,methods,and clinical effects of these techniques in patients with insomnia.It also analyzes the existing problems in their application and discusses future development and practice directions,aiming to provide references for establishing more standardized and scientific nursing plans for patients with insomnia.
文摘Objective: To evaluate the preventive effect of shoulder dystocia midwifery techniques combined with predictive nursing on shoulder dystocia. Methods: A total of 82 high-risk pregnant women with shoulder dystocia admitted for childbirth from January 2022 to January 2025 were selected and equally divided using a random number table. The experimental group received shoulder dystocia midwifery techniques combined with predictive nursing, while the reference group received routine midwifery care. Indicators such as the preventive effect on shoulder dystocia were compared between the two groups. Results: The incidence of shoulder dystocia in the experimental group was lower than that in the reference group, the duration of labor was shorter, the amount of intra-partum bleeding was less, the incidence of adverse delivery outcomes was lower, and the score for fear of childbirth after intervention was lower than that in the reference group (p < 0.05). Conclusion: Implementing shoulder dystocia midwifery techniques combined with predictive nursing for high-risk pregnant women with shoulder dystocia can prevent shoulder dystocia and other adverse delivery outcomes, shorten the duration of labor, reduce intra-partum bleeding, and alleviate pregnant women’s fear of childbirth, demonstrating high nursing value.
文摘1.Introduction.Pancreaticoduodenectomy is an essential surgical procedure for the treatment of malignant tumors in the pancreatic head,distal common bile duct,and duodenal papilla,and is widely used in clinical practice.One of the primary determinants of surgical success is the durability of the pancreaticojejunal anastomosis.
