BACKGROUND Cervical pregnancy is increasing in morbidity,and a definite diagnosis in early stages is challenging due to its specific onset site.Surgery is the mainstay of treatment for cervical pregnancy,but it may re...BACKGROUND Cervical pregnancy is increasing in morbidity,and a definite diagnosis in early stages is challenging due to its specific onset site.Surgery is the mainstay of treatment for cervical pregnancy,but it may result in the loss of natural fertility.Therefore,it is a great challenge to pursue a safe and effective treatment for cervical pregnancy.CASE SUMMARY We report the case of a cervical pregnancy successfully treated by ultrasoundguided cervical-intramuscular lauromacrogol injection combined with hysteroscopy.A 23-year-old woman with minor irregular vaginal bleeding was admitted to our department with suspected ectopic pregnancy.Transvaginal ultrasound revealed a gestational sac(approximately 22 mm x 13 mm)situated in the cervical canal with a yolk sac and blood flow signals.No cardiac activity was detected.Serum beta progesterone was 17.06 ng/m L,and serum beta human chorionic gonadotropin(β-HCG)was 5077.0 IU/L.The patient was diagnosed with cervical pregnancy.She was treated by ultrasound-guided cervicalintramuscular injections of lauromacrogol(3 m L)in combination with aborting under hysteroscopic visualization.A gradual decrease inβ-HCG levels and normal ultrasound findings were observed.Postoperative pathologic examination showed the presence of villi and changes in the endometrium in the secretory phase.The patient was discharged on day 6,and herβ-HCG level was 0.67 m IU/m L after 1 wk.There was no statistical difference between baseline and 1-week postoperative data in terms of serum indices including liver function,renal function,and routine blood analysis after treatment.The patient subsequently became pregnant 2 mo later and no abnormalities were detected on routine screening during pregnancy.CONCLUSION Ultrasound-guided cervical-intramuscular lauromacrogol injection combined with hysteroscopy may be effective and safe in the treatment of cervical pregnancy.展开更多
BACKGROUND Gastric duplication cysts are very rare disease that are mainly diagnosed by endoscopic ultrasonographic fine-needle aspiration biopsy.In the past,this disease was usually treated with traditional surgery a...BACKGROUND Gastric duplication cysts are very rare disease that are mainly diagnosed by endoscopic ultrasonographic fine-needle aspiration biopsy.In the past,this disease was usually treated with traditional surgery and rarely with minimally invasive endoscopic surgery.However,minimally invasive endoscopic therapy has many advantages,such as no skin wound,organ preservation,postoperative pain reduction,early food intake,fewer postoperative complications,and shorter post-procedure hospitalization.CASE SUMMARY We report a case of endoscopic ultrasonography-guided fine-needle aspiration(EUS-FNA)combined with lauromacrogol sclerotherapy for pyloric obstruction due to gastric duplication cysts.CONCLUSION EUS-FNA combined with lauromacrogol sclerotherapy provides a new option for the treatment of gastrointestinal duplication cysts.展开更多
BACKGROUND Colorectal cavernous hemangioma is a rare vascular malformation resulting in recurrent lower gastrointestinal hemorrhage,and can be misinterpreted as colitis.Surgical resection is currently the mainstay of ...BACKGROUND Colorectal cavernous hemangioma is a rare vascular malformation resulting in recurrent lower gastrointestinal hemorrhage,and can be misinterpreted as colitis.Surgical resection is currently the mainstay of treatment,with an emphasis on sphincter preservation.CASE SUMMARY We present details of two young patients with a history of persistent hematochezia diagnosed with colorectal cavernous hemangioma by endoscopic ultrasound(EUS).Cavernous hemangioma was relieved by several EUS-guided lauromacrogol injections and the patients achieved favorable clinical prognosis.CONCLUSION Multiple sequential EUS-guided injections of lauromacrogol is a safe,effective,cost-efficient,and minimally invasive alternative for colorectal cavernous hemangioma.展开更多
Objective:To study the curative effect and prognosis of endoscopic tissue glue + lauromacrogol therapy for patients with cirrhosis and variceal bleeding.Methods: Patients with cirrhosis and variceal bleeding who under...Objective:To study the curative effect and prognosis of endoscopic tissue glue + lauromacrogol therapy for patients with cirrhosis and variceal bleeding.Methods: Patients with cirrhosis and variceal bleeding who underwent endoscopic hemostasis in the First Hospital of Yulin between March 2015 and February 2018 were retrospectively studied and divided into the observation group who accepted endoscopic hemostasis by lauromacrogol - tissue glue - lauromacrogol solution and the control group who accepted endoscopic hemostasis by lipiodol - tissue glue - lipiodol solution according to the history data. After treatment, the hemostasis time was observed, and the differences in blood routine indicators, stress-related hormones, oxidation-related mediators and inflammation-related mediators were compared.Results: The mean hemostasis time of observation group was shorter than that of control group, hemoglobin and hematokrit after 24 h of treatment were higher than those of control group, and serum GAS, AT-II, NE, E, Cor, MDA, LPO, NO, iNOS, p38MAPK, NF-κB, TNF-α, IL-6 and IL-8 levels were lower than those of control group.Conclusion: Endoscopic tissue glue combined with lauromacrogol therapy is better than tissue glue combined with lipiodol therapy in hemostasis, and can also relieve the oxidative stress response and inflammatory response.展开更多
目的观察评估直肠黏膜柱状缝合(Block)术联合聚桂醇注射在治疗女性直肠前突中的临床疗效和安全性。方法该研究回顾性分析2022年1月至2023年12月在南京医科大学附属逸夫医院接受治疗的90例女性直肠前突患者。按手术治疗方式分为三组:Bloc...目的观察评估直肠黏膜柱状缝合(Block)术联合聚桂醇注射在治疗女性直肠前突中的临床疗效和安全性。方法该研究回顾性分析2022年1月至2023年12月在南京医科大学附属逸夫医院接受治疗的90例女性直肠前突患者。按手术治疗方式分为三组:Block术联合聚桂醇注射术(BP组)30例、单纯Block术(B组)30例和传统吻合器痔上黏膜环切术(procedure for prolapse and hemorrhoids,PPH)术(H组)30例。比较三组患者的一般临床资料,围术期各项指标、围术期患者Longo′s排便梗阻综合征(Longo′s ODS)评分、手术前后直肠前突程度、手术前后肛门直肠测压相关指标、手术疗效及围术期并发症情况。结果H组患者术中出血量显著高于B组和BP组(P<0.05)。BP组在术后24 h VAS评分和住院时间方面优于H组和B组(P<0.05)。术前三组患者的Longo′s ODS评分、直肠前突深度、肛管静息压和残余压差异无统计学意义(P>0.05);术后BP组的Longo′s ODS评分和直肠前突深度显著优于B组和H组(P<0.05)。术后肛管静息压和残余压在三组间差异无统计学意义(P>0.05),但BP组更接近正常范围。BP组的总体显效率为93.3%,高于B组的73.3%和H组的66.7%(P<0.05);三组患者并发症发生率差异无统计学意义(P>0.05)。结论Block术联合聚桂醇注射术是治疗女性直肠前突的安全有效的方法,疗效优于单纯行PPH术及Block术,可有效恢复女性直肠生理解剖形态,改善患者临床症状。展开更多
目的探讨1%聚桂醇泡沫硬化剂局部注射联合普萘洛尔治疗混合型婴幼儿血管瘤的临床治疗效果。方法选取我院2023年1月至2025年1月收治的103例混合型婴幼儿血管瘤患儿为研究对象,采用随机分组法分为观察组(53例)和对照组(50例)。对照组给予...目的探讨1%聚桂醇泡沫硬化剂局部注射联合普萘洛尔治疗混合型婴幼儿血管瘤的临床治疗效果。方法选取我院2023年1月至2025年1月收治的103例混合型婴幼儿血管瘤患儿为研究对象,采用随机分组法分为观察组(53例)和对照组(50例)。对照组给予普萘洛尔治疗,观察组给予普萘洛尔联合1%聚桂醇泡沫硬化剂局部注射治疗。记录并比较两组的临床治疗效果和不良反应发生情况。检测并比较两组患儿治疗前、后的血清血管内皮生长因子-A(VEGF-A)、表皮生长因子样结构域7(EGFL7)、缺氧诱导因子-1α(HIF-1α)、基质金属蛋白酶-9(MMP-9)水平。结果观察组的临床总有效率为94.34%,显著高于对照组的80.00%(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗后,观察组血清VEGF-A[(203.17±39.28)pg/m L vs.(278.65±43.68)pg/mL]、EGFL7[(6.89±1.75)pg/mL vs.(15.29±3.26)pg/mL]、HIF-1α[(0.15±0.02)mg/L vs.(0.18±0.03)mg/L]、MMP-9[(762.96±156.79)pg/mLvs.(1057.59±166.08)pg/mL]水平均较对照组低(P<0.05)。结论1%聚桂醇泡沫硬化剂局部注射联合普萘洛尔对混合型婴幼儿血管瘤治疗效果显著,可降低患儿血清VEGF-A、EGFL7、HIF-1α、MMP-9水平,且安全性良好。展开更多
文摘BACKGROUND Cervical pregnancy is increasing in morbidity,and a definite diagnosis in early stages is challenging due to its specific onset site.Surgery is the mainstay of treatment for cervical pregnancy,but it may result in the loss of natural fertility.Therefore,it is a great challenge to pursue a safe and effective treatment for cervical pregnancy.CASE SUMMARY We report the case of a cervical pregnancy successfully treated by ultrasoundguided cervical-intramuscular lauromacrogol injection combined with hysteroscopy.A 23-year-old woman with minor irregular vaginal bleeding was admitted to our department with suspected ectopic pregnancy.Transvaginal ultrasound revealed a gestational sac(approximately 22 mm x 13 mm)situated in the cervical canal with a yolk sac and blood flow signals.No cardiac activity was detected.Serum beta progesterone was 17.06 ng/m L,and serum beta human chorionic gonadotropin(β-HCG)was 5077.0 IU/L.The patient was diagnosed with cervical pregnancy.She was treated by ultrasound-guided cervicalintramuscular injections of lauromacrogol(3 m L)in combination with aborting under hysteroscopic visualization.A gradual decrease inβ-HCG levels and normal ultrasound findings were observed.Postoperative pathologic examination showed the presence of villi and changes in the endometrium in the secretory phase.The patient was discharged on day 6,and herβ-HCG level was 0.67 m IU/m L after 1 wk.There was no statistical difference between baseline and 1-week postoperative data in terms of serum indices including liver function,renal function,and routine blood analysis after treatment.The patient subsequently became pregnant 2 mo later and no abnormalities were detected on routine screening during pregnancy.CONCLUSION Ultrasound-guided cervical-intramuscular lauromacrogol injection combined with hysteroscopy may be effective and safe in the treatment of cervical pregnancy.
文摘BACKGROUND Gastric duplication cysts are very rare disease that are mainly diagnosed by endoscopic ultrasonographic fine-needle aspiration biopsy.In the past,this disease was usually treated with traditional surgery and rarely with minimally invasive endoscopic surgery.However,minimally invasive endoscopic therapy has many advantages,such as no skin wound,organ preservation,postoperative pain reduction,early food intake,fewer postoperative complications,and shorter post-procedure hospitalization.CASE SUMMARY We report a case of endoscopic ultrasonography-guided fine-needle aspiration(EUS-FNA)combined with lauromacrogol sclerotherapy for pyloric obstruction due to gastric duplication cysts.CONCLUSION EUS-FNA combined with lauromacrogol sclerotherapy provides a new option for the treatment of gastrointestinal duplication cysts.
基金Supported by Natural Science Foundation of Zhejiang Province,No.LY20H030010Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2019-KY1-001-181.
文摘BACKGROUND Colorectal cavernous hemangioma is a rare vascular malformation resulting in recurrent lower gastrointestinal hemorrhage,and can be misinterpreted as colitis.Surgical resection is currently the mainstay of treatment,with an emphasis on sphincter preservation.CASE SUMMARY We present details of two young patients with a history of persistent hematochezia diagnosed with colorectal cavernous hemangioma by endoscopic ultrasound(EUS).Cavernous hemangioma was relieved by several EUS-guided lauromacrogol injections and the patients achieved favorable clinical prognosis.CONCLUSION Multiple sequential EUS-guided injections of lauromacrogol is a safe,effective,cost-efficient,and minimally invasive alternative for colorectal cavernous hemangioma.
文摘Objective:To study the curative effect and prognosis of endoscopic tissue glue + lauromacrogol therapy for patients with cirrhosis and variceal bleeding.Methods: Patients with cirrhosis and variceal bleeding who underwent endoscopic hemostasis in the First Hospital of Yulin between March 2015 and February 2018 were retrospectively studied and divided into the observation group who accepted endoscopic hemostasis by lauromacrogol - tissue glue - lauromacrogol solution and the control group who accepted endoscopic hemostasis by lipiodol - tissue glue - lipiodol solution according to the history data. After treatment, the hemostasis time was observed, and the differences in blood routine indicators, stress-related hormones, oxidation-related mediators and inflammation-related mediators were compared.Results: The mean hemostasis time of observation group was shorter than that of control group, hemoglobin and hematokrit after 24 h of treatment were higher than those of control group, and serum GAS, AT-II, NE, E, Cor, MDA, LPO, NO, iNOS, p38MAPK, NF-κB, TNF-α, IL-6 and IL-8 levels were lower than those of control group.Conclusion: Endoscopic tissue glue combined with lauromacrogol therapy is better than tissue glue combined with lipiodol therapy in hemostasis, and can also relieve the oxidative stress response and inflammatory response.
文摘目的观察评估直肠黏膜柱状缝合(Block)术联合聚桂醇注射在治疗女性直肠前突中的临床疗效和安全性。方法该研究回顾性分析2022年1月至2023年12月在南京医科大学附属逸夫医院接受治疗的90例女性直肠前突患者。按手术治疗方式分为三组:Block术联合聚桂醇注射术(BP组)30例、单纯Block术(B组)30例和传统吻合器痔上黏膜环切术(procedure for prolapse and hemorrhoids,PPH)术(H组)30例。比较三组患者的一般临床资料,围术期各项指标、围术期患者Longo′s排便梗阻综合征(Longo′s ODS)评分、手术前后直肠前突程度、手术前后肛门直肠测压相关指标、手术疗效及围术期并发症情况。结果H组患者术中出血量显著高于B组和BP组(P<0.05)。BP组在术后24 h VAS评分和住院时间方面优于H组和B组(P<0.05)。术前三组患者的Longo′s ODS评分、直肠前突深度、肛管静息压和残余压差异无统计学意义(P>0.05);术后BP组的Longo′s ODS评分和直肠前突深度显著优于B组和H组(P<0.05)。术后肛管静息压和残余压在三组间差异无统计学意义(P>0.05),但BP组更接近正常范围。BP组的总体显效率为93.3%,高于B组的73.3%和H组的66.7%(P<0.05);三组患者并发症发生率差异无统计学意义(P>0.05)。结论Block术联合聚桂醇注射术是治疗女性直肠前突的安全有效的方法,疗效优于单纯行PPH术及Block术,可有效恢复女性直肠生理解剖形态,改善患者临床症状。
文摘目的探讨1%聚桂醇泡沫硬化剂局部注射联合普萘洛尔治疗混合型婴幼儿血管瘤的临床治疗效果。方法选取我院2023年1月至2025年1月收治的103例混合型婴幼儿血管瘤患儿为研究对象,采用随机分组法分为观察组(53例)和对照组(50例)。对照组给予普萘洛尔治疗,观察组给予普萘洛尔联合1%聚桂醇泡沫硬化剂局部注射治疗。记录并比较两组的临床治疗效果和不良反应发生情况。检测并比较两组患儿治疗前、后的血清血管内皮生长因子-A(VEGF-A)、表皮生长因子样结构域7(EGFL7)、缺氧诱导因子-1α(HIF-1α)、基质金属蛋白酶-9(MMP-9)水平。结果观察组的临床总有效率为94.34%,显著高于对照组的80.00%(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗后,观察组血清VEGF-A[(203.17±39.28)pg/m L vs.(278.65±43.68)pg/mL]、EGFL7[(6.89±1.75)pg/mL vs.(15.29±3.26)pg/mL]、HIF-1α[(0.15±0.02)mg/L vs.(0.18±0.03)mg/L]、MMP-9[(762.96±156.79)pg/mLvs.(1057.59±166.08)pg/mL]水平均较对照组低(P<0.05)。结论1%聚桂醇泡沫硬化剂局部注射联合普萘洛尔对混合型婴幼儿血管瘤治疗效果显著,可降低患儿血清VEGF-A、EGFL7、HIF-1α、MMP-9水平,且安全性良好。
