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How Latin America Can Better Benefit from the Belt and Road Initiative
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作者 Jiang Shixue 《China's Foreign Trade》 2025年第5期23-25,共3页
On May 17,2017,President Xi Jinping met with Argentine President Mauricio Macri at the Great Hall of the People in Beijing,where they were attending the Belt and Road Forum for International Cooperation.Xi stated that... On May 17,2017,President Xi Jinping met with Argentine President Mauricio Macri at the Great Hall of the People in Beijing,where they were attending the Belt and Road Forum for International Cooperation.Xi stated that,as Latin America is a natural extension of the 21st Century Maritime Silk Road,China is willing to strengthen cooperation with Latin America,align development strategies within the framework of the Belt and Road Initiative(BRI),promote common development,and build a China-Latin America community with a shared future. 展开更多
关键词 shared future latin America latin america development strategy belt road forum belt road initiative bri promote common developmentand China latin America cooperation latin americaalign development strategies
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The 7th China-Latin America and Caribbean Think Tank Forum Held in CIIS
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《China International Studies》 2025年第3期F0002-F0002,共1页
On June 20,the 7th China-Latin America and Caribbean Think Tank Forum was held in Beijing.The forum carried the theme“Working Together to Build a China-LAC Community with a Shared Future.”Assistant Foreign Minister ... On June 20,the 7th China-Latin America and Caribbean Think Tank Forum was held in Beijing.The forum carried the theme“Working Together to Build a China-LAC Community with a Shared Future.”Assistant Foreign Minister Miao Deyu attended the opening ceremony and delivered remarks.Leonel Caraballo Maqueira,Vice President of the Cuban Diplomatic Academy,and Martin Charles,Ambassador of Dominica to China and Representative of the Latin American and Caribbean Diplomatic Corps in China,attended the meeting and delivered speeches. 展开更多
关键词 China latin America Caribbean Community latin American Caribbean Diplomatic Corps Cuban Diplomatic Academy Dominica Ambassador China LAC Think Tank Forum Shared Future Assistant Foreign Minister Miao Deyu
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The Green Transition in Latin America: Progress and Prospects
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作者 Lyu Yang Zhang Ruiting 《Contemporary International Relations》 2025年第1期96-111,共16页
Green transition fosters a harmonious balance between economic growth and ecological preservation.It drives innovation and the development of sustainable technologies and practices,which in turn create new economic op... Green transition fosters a harmonious balance between economic growth and ecological preservation.It drives innovation and the development of sustainable technologies and practices,which in turn create new economic opportunities.In recent years,faced with severe development pressures caused by climate change and environmental issues,Latin American countries have stepped up efforts to implement green transition plans and achieved certain progress in sectors such as renewable energy,eco-friendly manufacturing,and green infrastructure.Notably,Latin America's green economy transition approach coincides with China's drive to accelerate green transition in all areas of economic and social development.Closer“green cooperation”with China will significantly boost Latin America's transition towards a green economy. 展开更多
关键词 China-latin America cooperation climate change green economy transition latin America
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Science Fiction in Latin America,Interdisciplinary Paradigm,and the Regional Studies for Latin America:An Interview with Joanna Page
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作者 Jiang Yuqin Joanna Page 《外国文学研究》 北大核心 2025年第2期1-12,共12页
Joanna Page is Director of CRASSH and Professor of Latin American Studies at the University of Cambridge.Her research interests are generally connected to the relationship between science and culture in Latin America.... Joanna Page is Director of CRASSH and Professor of Latin American Studies at the University of Cambridge.Her research interests are generally connected to the relationship between science and culture in Latin America.She has also worked on questions of memory,modernity,capitalism,posthumanism,new materialism,decoloniality,ecology,and environmental thought.This interview covers three main aspects:the characteristics of science fiction texts in Latin America,the interdisciplinary research models at the intersection of science,literature,and art,and Latin America as a field of regional studies.Professor Page starts with Argentine science fiction novels and expands the discussion to include graphic novels in Latin America,outlining the panorama of science fiction and its indigenous features.The conversation delves into the literary and technological relationships within Latin American science fiction texts.Building upon this foundation,this interview explores the interdisciplinary research paradigms concerning the relationship between science and culture,aiming to contribute to regional studies by exploring new pathways for interdisciplinary,cross-regional,and trans-media research. 展开更多
关键词 science fiction in latin America interdisciplinary studies regional studies
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As Mexico Presses To Speed Up“Building”,Chinese Bricks Build A Latin-American Dream
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作者 Liu Xinwei 《China's Foreign Trade》 2025年第5期53-57,共5页
On the morning of October 15,people from different countries will queue up at the entrance of Centro Banamex,the international convention and exhibition center in Mexico.There are local dealers present,Brazilian build... On the morning of October 15,people from different countries will queue up at the entrance of Centro Banamex,the international convention and exhibition center in Mexico.There are local dealers present,Brazilian builders identifiable by their yellow-green,fluorescent vests,Canadian buyers carrying computer bags,and a group of Chinese individuals with aluminum alloy suitcases labeled“Foshan Ceramics”,“Yongkang Hardware”,and“Anji Bamboo Floor”. 展开更多
关键词 EXHIBITION latin america mexico builders TRADE china aluminum alloy suitcases chinese individuals
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Critical Minerals Governance Strategies of Latin American Countries
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作者 Yan Jin Shao Jingyi Ling Xiao 《Contemporary International Relations》 2025年第2期86-109,共24页
Latin American countries possess rich resources of critical minerals,which have long underpinned their economic growth and social advancement.Meanwhile,however,these countries are grappling with excessive external dep... Latin American countries possess rich resources of critical minerals,which have long underpinned their economic growth and social advancement.Meanwhile,however,these countries are grappling with excessive external dependency,underdeveloped industrial chains,low value-added exports,and weak international discourse power.In recent years,due to various external and internal factors,such as the restructuring of the global supply chains,the intensification of major-country rivalry,the transformation of regional development patterns,and the resurgence of resource nationalism,Latin American countries have been more aware of the strategic value and security attribute of critical minerals.Increasingly,they have strengthened the strategic governance of these resources from the national security perspective to defend national sovereignty over resources,enhance the resilience of their supply chains,improve industrial independence,and protect ecological security.Towards these ends,Latin American countries have been actively exploring and developing critical minerals strategies that align with global geopolitical changes and regional transformation needs.In practice,Latin American countries have tightened their control over critical minerals,considered both short-term economic gains and long-term development interests,balanced environmental protection and social responsibility,and conducted international mining cooperation based on the principles of diversity and balance.They are striving to maximize their security and development interests by seeking high-level security and high-quality development of critical mineral resources. 展开更多
关键词 critical mineral development and transformation latin America major-country rivalry resource nationalism
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Challenges and opportunities in the energy transition of agribusiness:A deep dive into the rebound effect in Latin America
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作者 Fábio DE OLIVEIRA NEVES Eduardo Gomes SALGADO +2 位作者 Mateus CURY Jean Marcel Sousa LIRA Breno Régis SANTOS 《Regional Sustainability》 2025年第3期1-18,共18页
Growing climate change concerns have intensified the focus on agribusiness sustainability,driving an urgent energy transition to improve production efficiency and mitigate environmental harm.The complex interplay betw... Growing climate change concerns have intensified the focus on agribusiness sustainability,driving an urgent energy transition to improve production efficiency and mitigate environmental harm.The complex interplay between energy efficiency and energy consumption highlights the essential role of strategic energy policies in ensuring sustainable development.This study used the Double-Log regression model with bootstrap resampling to examine the rebound effect in the energy transition of agribusiness focusing on five Latin American countries including Brazil,Argentina,Uruguay,Colombia,and Mexico based on the agricultural sector data during 2010–2022.The findings revealed that the rebound effect significantly influences energy transition,with varying degrees of impact across agricultural sectors.This study identified partial rebound effect across all five countries,with elasticity coefficient varying from 9.63%(Colombia’s coffee sector)to 89.12%(Brazil’s livestock sector).In Brazil’s sugarcane sector,nonrenewable energy,agricultural employment,and irrigation efficiency were identified as key factors influencing energy consumption,while in livestock sector,energy consumption was affected by CH_(4)emissions,income and well-being of farmers,water consumption,and water conservation practices.In Mexico’s livestock sector,CH_(4)emissions,nonrenewable energy,and water conservation practices were the key factors affecting energy consumption.In Argentina’s sugarcane sector,pesticides,NO_(2)emissions,renewable energy,and agricultural employment were the key factors affecting energy consumption,while renewable energy,income and well-being of farmers,and water consumption were the key factors affecting energy consumption in livestock sector.In Uruguay’s livestock sector,non-renewable energy,income and well-being of farmers,and irrigation efficiency were the key factors affecting energy consumption.In Colombia’coffee sector,NO_(2)emissions and irrigation efficiency were identified as key factors influencing energy consumption.Finally,this study reinforces the importance of aligning energy transition with Sustainable Development Goals(SDGs),ensuring that energy efficiency gains do not inadvertently increase energy consumption or environmental degradation. 展开更多
关键词 Energy efficiency Energy consumption Greenhouse gas emissions Rebound effect Double-Log regression model latin America
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Challenges in the Transition and Transfer of Young Adults with Congenital Heart Disease in Latin America and the Caribbean: The “Timeliness Principle”
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作者 John J.Araujo 《Congenital Heart Disease》 2025年第1期61-75,共15页
Today,more than 90%of children who are born with congenital heart disease survive and reach adulthood,especially in developed countries.Consequently,the population of adults with congenital heart disease has increased... Today,more than 90%of children who are born with congenital heart disease survive and reach adulthood,especially in developed countries.Consequently,the population of adults with congenital heart disease has increased signiffcantly over the last few decades.In Latin America and the Caribbean countries,this same scenario is occurring at an accelerated pace.Loss to follow-up is a global problem in adults with congenital heart disease,ranging from 30–60%.In Latin America and Caribbean countries,it is estimated that less than 10%of adults with congenital heart disease are being followed.The small number of specialists and adult congenital heart disease specialized centers,as well as virtually nonexistent transition and transfer programs,are some of the reasons for this.This article is a narrative review of the current status of the transition and transfer of young adults with congenital heart disease,with a special focus on Latin America and Caribbean countries.It describes the general concepts of transition and transfer,analyzes barriers and,ffnally,presents specialized care alternatives that would reduce losses and improve this population’s care. 展开更多
关键词 Adults with congenital heart disease transition and transfer loss to follow-up transition program latin America and the Caribbean
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Sequential search-based Latin hypercube sampling scheme for digital twin uncertainty quantification with application in EHA
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作者 Dong LIU Shaoping WANG +1 位作者 Jian SHI Di LIU 《Chinese Journal of Aeronautics》 2025年第4期176-192,共17页
For uncertainty quantification of complex models with high-dimensional,nonlinear,multi-component coupling like digital twins,traditional statistical sampling methods,such as random sampling and Latin hypercube samplin... For uncertainty quantification of complex models with high-dimensional,nonlinear,multi-component coupling like digital twins,traditional statistical sampling methods,such as random sampling and Latin hypercube sampling,require a large number of samples,which entails huge computational costs.Therefore,how to construct a small-size sample space has been a hot issue of interest for researchers.To this end,this paper proposes a sequential search-based Latin hypercube sampling scheme to generate efficient and accurate samples for uncertainty quantification.First,the sampling range of the samples is formed by carving the polymorphic uncertainty based on theoretical analysis.Then,the optimal Latin hypercube design is selected using the Latin hypercube sampling method combined with the"space filling"criterion.Finally,the sample selection function is established,and the next most informative sample is optimally selected to obtain the sequential test sample.Compared with the classical sampling method,the generated samples can retain more information on the basis of sparsity.A series of numerical experiments are conducted to demonstrate the superiority of the proposed sequential search-based Latin hypercube sampling scheme,which is a way to provide reliable uncertainty quantification results with small sample sizes. 展开更多
关键词 Digital Twin(DT) Genetic algorithms(GA) Optimal latin Hypercube Design(Opt LHD) Sequential test Uncertainty Quantification(UQ) EHA
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Efficiency and sustainability of the tourism industry in Latin America
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作者 Clara Inés PARDO MARTÍNEZ Alexander COTTE POVEDA 《Regional Sustainability》 2024年第4期57-70,共14页
The tourism industry is economically very important.According to the World Travel Tourism Council,in 2019,the tourism industry accounted for a quarter of all new jobs created worldwide,10.3%of all jobs,and 9.6×10... The tourism industry is economically very important.According to the World Travel Tourism Council,in 2019,the tourism industry accounted for a quarter of all new jobs created worldwide,10.3%of all jobs,and 9.6×1012 USD of the global gross domestic product.This study aimed to calculate the tourism efficiency index for different Latin American countries from 2010 to 2021 using data envelopment analysis,which analyzes the relationships between input variables(including the number of employees in the tourism industry and the number of hotel-type establishments)and output variables(including tourism expenditures in other countries and public social expenditures in recreation and culture per capita).Additionally,this study aimed to identify the countries with greater tourism development and the factors that may affect the development of the tourism industry through the stochastic frontier production function.The results of the tourism efficiency index for Central America(including Costa Rica,Dominica,El Salvador,Honduras,Mexico,and Panama)and South America(including Argentina,Brazil,Chile,Colombia,Ecuador,Paraguay,Peru,and Uruguay)exhibited different trends.However,after the global health crisis,the tourism industry recovered,showing new opportunities to promote sustainability.The results of the stochastic frontier production function demonstrated that countries with higher levels of inbound and outbound tourism,contribution of tourism to the economy,natural resources,and literacy rate exhibited more efficient tourism industry,whereas countries with higher pollution levels exhibited less efficient tourism industry.The findings of this study could allow us to formulate suitable public policies to promote tourism,maintain natural resources,and diversify these sectors with more inclusive programmes that can facilitate growth and benefit vulnerable communities. 展开更多
关键词 Tourism industry Tourism efficiency index Stochastic frontier production function Data envelopment analysis(DEA) latin America
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China-Latin America Green Cooperation under the Global Development Initiative
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作者 Cao Ting 《China International Studies》 2024年第3期73-99,共27页
The international development environment is entering a chaotic and volatile period.The world economy remains sluggish,while geopolitical conflicts,climate change,food crisis and a multitude of other challenges become... The international development environment is entering a chaotic and volatile period.The world economy remains sluggish,while geopolitical conflicts,climate change,food crisis and a multitude of other challenges become more closely intertwined and mutually reinforcing.In this context,countries across the world have been prompted to look for healthy,feasible and sustainable solutions to keep their socioeconomic development momentum on track. 展开更多
关键词 latin mutually PROMPT
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基于Latin方抽样和修正的Latin方抽样的可靠性灵敏度估计及其方差分析 被引量:14
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作者 万越 吕震宙 袁修开 《机械强度》 EI CAS CSCD 北大核心 2008年第6期927-934,共8页
运用Latin方抽样(Latin hypercube sampling)方法和经统计相关减小方程修正后的Latin方抽样(updated Latin hypercube sampling)方法对结构进行可靠性灵敏度估计及其方差分析。单模式和多模式的数值及工程算例说明,可靠性灵敏度分析的La... 运用Latin方抽样(Latin hypercube sampling)方法和经统计相关减小方程修正后的Latin方抽样(updated Latin hypercube sampling)方法对结构进行可靠性灵敏度估计及其方差分析。单模式和多模式的数值及工程算例说明,可靠性灵敏度分析的Latin方抽样和修正的Latin方抽样在样本容量较小时都可以得到比Monte Carlo抽样方法更稳定的估计结果。采用Latin方抽样可以得到可靠性灵敏度的无偏估计,而修正的Latin方抽样方法在样本容量较小的情况下得到的可靠性灵敏度估计值的方差的分散性较Latin方抽样有进一步的减小。Latin方抽样和修正的Latin方抽样方法对基本变量的分布形式和相关性等均无限定,是适用于结构可靠性灵敏度分析的一种有效而实用的小样本抽样方法。 展开更多
关键词 latin方抽样 修正的latin方抽样 统计相关减小方程 方差 MONTE Carlo
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Sociodemographic determinants associated with breastfeeding in term infants with low birth weight in Latin American countries
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作者 Carlos Javier Avendaño-Vásquez Magda Liliana Villamizar-Osorio +2 位作者 Claudia Jazmin Niño-Peñaranda Judith Medellín-Olaya Nadia Carolina Reina-Gamba 《World Journal of Clinical Pediatrics》 2024年第1期141-149,共9页
BACKGROUND A progressive decrease in exclusive breastfeeding(BF)is observed in Latin America and the Caribbean compared with global results.The possibility of being breastfed and continuing BF for>6 months is lower... BACKGROUND A progressive decrease in exclusive breastfeeding(BF)is observed in Latin America and the Caribbean compared with global results.The possibility of being breastfed and continuing BF for>6 months is lower in low birth weight than in healthy-weight infants.AIM To identify factors associated with BF maintenance and promotion,with particular attention to low-and middle-income countries,by studying geographic,socioeconomic,and individual or neonatal health factors.METHODS A scoping review was conducted in 2018 using the conceptual model of social determinants of health published by the Commission on Equity and Health Inequalities in the United States.The extracted data with common characteristics were synthesized and categorized into two main themes:(1)Sociodemographic factors and proximal determinants involved in the initiation and maintenance of BF in low-birth-weight term infants in Latin America;and(2)individual characteristics related to the self-efficacy capacity for BF maintenance and adherence in low-birth-weight term infants.RESULTS This study identified maternal age,educational level,maternal economic capacity,social stratum,exposure to BF substitutes,access to BF information,and quality of health services as mediators for maintaining BF.CONCLUSION Individual self-efficacy factors that enable BF adherence in at-risk populations should be analyzed for better health outcomes. 展开更多
关键词 BREASTFEEDING Low birth weight latin America SELF-EFFICACY Social determinants of health
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Integrating geoethics in tertiary education:a strategy for sustainable development in Latin America and the Caribbean
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作者 Sandra Villacorta Luisa Pinto +1 位作者 Antoni Camprubí Yosbanis Cervantes 《Episodes》 2024年第4期733-751,共19页
This study highlights the critical need for geoethics integration into higher education curricula across the Latin America and the Caribbean region,grappling with issues like sustainable development,responsible mining... This study highlights the critical need for geoethics integration into higher education curricula across the Latin America and the Caribbean region,grappling with issues like sustainable development,responsible mining,adaptation to climate change,and biodiversity conservation.Geoethics is essential for students to develop a holistic understanding of resources and ecosystems,promoting ethical attitudes and environmental responsibility.The proposed educational model includes geoethical principles,values,and case studies in geoscience courses,facing socio-economic-environmental impacts,sustainable resource management,and disaster risk reduction.The study identifies challenges in geoethics education,such as the lack of awareness of educators,insufficient resources,and fragmented efforts to develop the topic.Overcoming these obstacles requires a collaborative approach among educators,researchers,and professional bodies to develop educational materials,provide training,and facilitate knowledge exchange.The proposal of this study underscores the importance of collaborative initiatives among geoscience stakeholders in the region to ensure the successful incorporation of geoethics into educational frameworks.Education in geoethics is crucial for fostering informed and ethically conscious future geoscientists to better address the region's unique challenges. 展开更多
关键词 latin America educational model tertiary education biodiversity conservationgeoethics develop holistic understanding resources geoethics sustainable development
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Latin抽样法在导弹结构裂纹概率仿真中的应用
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作者 汤建湘 陈玉波 关正西 《上海航天》 1999年第4期23-26,共4页
提出了Latin抽样与分层抽样相结合的复合抽样方法,对于提高抽样精度和效率都有较为明显的作用,特别适用于结构裂纹概率的仿真和其它应用工程仿真计算。在复合抽样仿真计算示例中,对某型导弹的燃汽发生器进行了抽样仿真计算,所... 提出了Latin抽样与分层抽样相结合的复合抽样方法,对于提高抽样精度和效率都有较为明显的作用,特别适用于结构裂纹概率的仿真和其它应用工程仿真计算。在复合抽样仿真计算示例中,对某型导弹的燃汽发生器进行了抽样仿真计算,所得的抽样结果的精度和相关差都达到了令人满意的预期效果,与实验结果吻合。 展开更多
关键词 latin抽样法 导弹结构 裂纹概率 仿真
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An Upper Bound for the Number of Normalized Latin Square
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作者 DUAN Lian 《Chinese Quarterly Journal of Mathematics》 CSCD 北大核心 2006年第4期585-589,共5页
In this note, the author find an upper bound formula for the number of the p × p normalized Latin Square,the first row and column of which are both standard order 1, 2,…p.
关键词 latin square normalized latin square inclusion-exclusion principe
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Chinese companies' outward internationalization to emerging countries: The case of Latin America
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作者 Gaston Fornes Alan Butt-Philip 《Chinese Business Review》 2009年第7期13-28,共16页
This paper aims to review and analyze the literature on the expansion of Chinese firms to Latin America. In order to achieve this objective, it first reviews the literature on the internationalization of Chinese MNCs,... This paper aims to review and analyze the literature on the expansion of Chinese firms to Latin America. In order to achieve this objective, it first reviews the literature on the internationalization of Chinese MNCs, the theoretical frameworks discussed in the literature and the principal features of companies from China. Second, it describes the economic and political relations between the countries, specifically the threats and opportunities for Latin America and the trade and investment trends. The review shows that the majority of the current literature on Chinese MNCs has a focus on their expansion to developed countries, on the conceptual framework needed to understand this expansion, and on the competition for foreign investments from developed countries. As a result, the analysis makes evident that research gaps seem to exist in the following areas: (1) the relative value of Chinese companies' existing advantages, (2) the sustainability of these advantages once the lead, probably given by OEMs or JVs, had been exhausted, (3) research works based on quantitative and comparative data, (4) the motives for FDI, (5) the entry mode, configuration, control and strategy of Chinese companies investing in Latin America, and (6) the potential opportunities presented to European companies operating in Latin America. 展开更多
关键词 Chinese MNCs latin America Sino-latin American relations
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Impact of the COVID-19 Pandemic on Latin America and Its Related Thinking
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作者 Wu Hongying 《Contemporary International Relations》 2021年第4期80-94,共15页
The pandemic’s huge impact on all countries and regions is the biggest black swan event in 2020 and the biggest gray rhino event in 2021.Though Latin America was the last continent attacked by COVID-19,it became in 2... The pandemic’s huge impact on all countries and regions is the biggest black swan event in 2020 and the biggest gray rhino event in 2021.Though Latin America was the last continent attacked by COVID-19,it became in 2020 the designated epicenter of infection,surpassing Europe and catching up with the United States.The rapidity of spread in Latin America,the wide range and high incidence of infections,and the death toll were larger than in other places.The pandemic has resulted in the largest economic recession in Latin American history.It also has a significant impact on China-Latin America relations.When the pandemic in Latin American will end depends on large-scale,wide application of vaccines,strict prevention and control,and international cooperation.丁he pandemic reveals the fierce contradiction between society and nature. 展开更多
关键词 COVID-19 pandemic latin America China-latin America relations
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Latin方阵和二维量子漫步相结合的图像加密 被引量:1
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作者 蒋建伟 张田 +1 位作者 陈祯羽 马鸿洋 《电子科技大学学报》 EI CAS CSCD 北大核心 2023年第5期649-658,共10页
针对数字图像在网络传输过程中容易受到攻击导致信息泄漏的问题,在Arnold置乱变换的基础上引入量子漫步和Latin方阵,设计了一种新型的彩色图像加密方案。首先把彩色图像的三通道分离,用Arnold变换来对图像像素点置乱,量子漫步和Latin方... 针对数字图像在网络传输过程中容易受到攻击导致信息泄漏的问题,在Arnold置乱变换的基础上引入量子漫步和Latin方阵,设计了一种新型的彩色图像加密方案。首先把彩色图像的三通道分离,用Arnold变换来对图像像素点置乱,量子漫步和Latin方阵被用来处理置乱后图像的像素值,然后对处理之后的图像使用加取模扩散算法进一步改变图像的像素值,最后合并三通道加密图像得到彩色加密图像。量子漫步的作用是为该文的加密算法提供随机序列。该文对加密算法进行了实验仿真,在直方图、相关性、信息熵、噪声攻击、裁剪攻击等多个方面对实验结果进行了性能分析。仿真结果显示:加密图像的直方图均匀分布,像素点之间的相关性趋近于0,信息熵为7.9993,接近于8,说明该算法具有较不错的抵抗统计分析的能力;经过噪声攻击和裁剪攻击之后的加密图像经过解密之后,仍然可以看到原图像信息,表明该算法的鲁棒性是良好的;该加密算法的密钥空间足够大为1060且密钥敏感性良好,NPCR值接近于99.61%,UACI值接近于33.45%,证明该算法拥有抵抗差分攻击的能力。 展开更多
关键词 ARNOLD变换 图像加密 latin方阵 量子漫步
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Role of gene polymorphisms in gastric cancer and its precursor lesions:Current knowledge and perspectives in Latin American countries 被引量:6
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作者 Miguel Angel Chiurillo 《World Journal of Gastroenterology》 SCIE CAS 2014年第16期4503-4515,共13页
Latin America shows one of the highest incidence rates of gastric cancer in the world,with variations in mortality rates among nations or even within countries belonging to this region.Gastric cancer is the result of ... Latin America shows one of the highest incidence rates of gastric cancer in the world,with variations in mortality rates among nations or even within countries belonging to this region.Gastric cancer is the result of a multifactorial complex process,for which a multistep model of carcinogenesis is currently accepted.Additionally to the infection with Helicobacter pylori,that plays a major role,environmental factors as well as genetic susceptibility factors are significant players at different stages in the gastric cancer process.The differences in population origin,demographic structure,socio-economic development,and the impact of globalization lifestyles experienced in Latin America in the last decades,all together offer opportunities for studying in this context the influence of genetic polymorphisms in the susceptibility to gastric cancer.The aim of this article is to discuss current trends on gastric cancer in Latin American countries and to review the available published information about studies of association of gene polymorphisms involved in gastric cancer susceptibility from this region of the world.A total of 40 genes or genomic regions and69 genetic variants,58%representing markers involved in inflammatory response,have been used in a number of studies in which predominates a low number of individuals(cases and controls)included.Polymorphisms of IL-1B(-511 C/T,14 studies;-31 T/C,10 studies)and IL-1RN(variable number of tandem repeats,17 studies)are the most represented ones in the reviewed studies.Other genetic variants recently evaluated in large metaanalyses and associated with gastric cancer risk were also analyzed in a few studies[e.g.,prostate stem cell antigen(PSCA),CDH1,Survivin].Further and better analysis centered in gene polymorphisms linked to other covariates,epidemiological studies and the information provided by meta-analyses and genome-wide association studies should help to improve our understanding of gastric cancer etiology in order to develop appropriate health programs in Latin America. 展开更多
关键词 latin America Gastric cancer Precancerous lesions Gene polymorphisms Single nucleotide polymorphisms
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