Primary malignant melanoma of the larynx is extremely rare.This paper reports a case of a patient with primary malignant melanoma of the larynx.Preoperative laryngoscopy revealed a cauliflower-like mass in the supragl...Primary malignant melanoma of the larynx is extremely rare.This paper reports a case of a patient with primary malignant melanoma of the larynx.Preoperative laryngoscopy revealed a cauliflower-like mass in the supraglottic region,and a CT scan of the pharynx suggested laryngeal cancer with cervical lymph node metastasis.The patient underwent a total laryngectomy with lymph node dissection,and postoperative pathology confirmed a malignant melanoma in the supraglottic region of the larynx.展开更多
Objective: Laryngeal cancer is an important oncologic entity, whose prognosis depends on establishing appropriate preventive and diagnostic measures, especially in populations at higher risk.Methods: Epidemiologic inf...Objective: Laryngeal cancer is an important oncologic entity, whose prognosis depends on establishing appropriate preventive and diagnostic measures, especially in populations at higher risk.Methods: Epidemiologic information including worldwide incidence, prevalence, burden of health loss(disability-adjusted life year;DALYs) and mortality of larynx cancer was obtained from the Global Health Data Exchange(GHDx) database.Results: The current incidence, prevalence and mortality of laryngeal cancer are estimated at 2.76 cases/year per 100,000 inhabitants, 14.33 cases/year per 100,000 inhabitants and 1.66 deaths/year per 100,000 inhabitants,respectively, averaging 3.28 million DALYs each year. Incidence and prevalence have increased by 12% and 24%,respectively during the past 3 decades, whilst mortality has declined by around 5%. The epidemiologic burden of this malignancy is approximately 5-fold higher in males and increases in parallel with ageing, peaking after 65 years of age. Both incidence and mortality rates are higher in Europe and lower in Africa, but the ratio between deaths and incidence is the highest in Africa. Incidence has gradually declined in Europe during the past 3 decades, whilst it has increased in South-East Asia and Western Pacific. Cigarette smoking and alcohol abuse contribute for about 90% of overall worldwide mortality for laryngeal cancer.Conclusions: Laryngeal cancer still poses a high clinical and societal burden, with an escalating temporal trend not expected to reverse soon.展开更多
BACKGROUND Collision carcinoma is rare in clinical practice, especially in the head and neck region. In this paper, we report a case of squamous cell carcinoma(SCC) and neuroendocrine carcinoma(NEC) colliding in the l...BACKGROUND Collision carcinoma is rare in clinical practice, especially in the head and neck region. In this paper, we report a case of squamous cell carcinoma(SCC) and neuroendocrine carcinoma(NEC) colliding in the larynx and review 12 cases of collision carcinoma in the head and neck to further understand collision carcinoma, including its definition, diagnosis, and treatment.CASE SUMMARY A 61-year-old man presented with a 1-year history of hoarseness. Contrastenhanced magnetic resonance imaging of the larynx revealed that the right vocal cord had a nodule-like thickening with obvious enhancement. Laryngoscopy revealed a neoplasm on the right vocal cord, and a malignant tumor was initially considered. A frozen section of right vocal cord was performed under general anesthesia. The pathological result showed a malignant tumor in the right vocal cord. The tumor was excised with a CO_2 laser(Vc type). Routine postoperative pathology showed moderately differentiated SCC with small cell NEC in the right vocal cord. No metastatic lymph nodes or distant metastases were found on postoperative positron emission tomography/computed tomography. Because of the coexistence of SCC and NEC, the patient received adjuvant chemotherapy and radiotherapy. The patient was followed for 8 mo, and no recurrence or distant metastasis was found.CONCLUSION The treatment of collision carcinoma in the head and neck region is uncertain due to the small number of cases.展开更多
BACKGROUND Chondrosarcomas of the larynx are malignant tumours that most commonly originate from the hyaline cartilage.Chondrosarcoma of the larynx,the most common type of low-grade tumour,accounts for 1%of all laryng...BACKGROUND Chondrosarcomas of the larynx are malignant tumours that most commonly originate from the hyaline cartilage.Chondrosarcoma of the larynx,the most common type of low-grade tumour,accounts for 1%of all laryngeal neoplasms.CASE SUMMARY We present the case of a 60-year-old female patient who developed progressive hoarseness and shortness of breath over a 2-mo period.The patient had undergone resection of a laryngeal tumour 14 years before the aforementioned symptoms occurred,and histopathological analysis indicated that it was a chondroma.During the assessment of the patient,a submucosal,oval-shaped tumour was detected that was predominantly located on the left side of the larynx and was approximately 6 cm in size.The decision to perform left partial vertical laryngectomy was made.A pathohistological diagnosis of low-grade chondrosarcoma was made.Considering the results of pathohistological analysis and the positive margins of the resection,a total laryngectomy was performed.During the 12-mo follow-up,no local relapse or regional or distant metastases was detected.CONCLUSION Chondrosarcoma of the larynx must be considered in the differential diagnosis of laryngeal submucosal tumours.It is crucial to carefully sample of tumour tissue,differentiate chondroma and chondrosarcoma,and consider the possibility of malignant changes from chondroma to chondrosarcoma.展开更多
Gout is a metabolic disorder that is characterized by a deposition of monosodium urate crystals in the joint or soft tissue. Gout manifestations in head and neck region are rare, and larynx is an infrequently affected...Gout is a metabolic disorder that is characterized by a deposition of monosodium urate crystals in the joint or soft tissue. Gout manifestations in head and neck region are rare, and larynx is an infrequently affected location. We recently managed a case of a gouty tophus over the larynx. A 65-year-old male with a long history of gout without medical control. He has suffered from increasing hoarseness for six months. Laryngoscopy revealed a mass lesion over the right vocal process region without vocal paralysis. Laryngo-micro-surgery biopsy was taken, and pathology confirmed laryngeal gouty tophus without evidence of malignancy.展开更多
This article deals with a treatment of acute diseases of pharynx and larynx with bloodpricking therapy, in this treatment, a group of 79 patients accepted the treatment with this therapy.The therapy contains mainly tw...This article deals with a treatment of acute diseases of pharynx and larynx with bloodpricking therapy, in this treatment, a group of 79 patients accepted the treatment with this therapy.The therapy contains mainly two methods: Acupoint pricking and local scattered pricking. A good result is achieved. It proves that blood-pricking method can replace the antibiotics and alleviate the sufferer’s pain and economic burden. It is simple and easy to carry out, thus it can be spread extensively.展开更多
From July 1969 to November 1991, 4 patients with primary malignant lymphoma of the larynx were treated.One case was received radiotherapy and followed- up survey for 20 years being healthy, 3 case were received radiot...From July 1969 to November 1991, 4 patients with primary malignant lymphoma of the larynx were treated.One case was received radiotherapy and followed- up survey for 20 years being healthy, 3 case were received radiotherapy and chemotherapy. A total dose of 45-60 Gy was delivered. The disease can be classified four clinical types, (1) localized laryngeal lymphoma; (2) cephalocevical and larynx lymphoma; (3) laryngeal pieces region lymphoma; and (4) laryngeal pieces wildly spreaded lymphoma. The favorable prognostic factors were clinical course, clinical staging and the mode of treatment.展开更多
Summary: The inhibitory effects of two kinds of selective cyclooxygenase-2 inhibitors on the proliferation of human carcinoma of larynx Hep-2 in vitro and their corresponding mechanisms were investigated. Hep-2 cells ...Summary: The inhibitory effects of two kinds of selective cyclooxygenase-2 inhibitors on the proliferation of human carcinoma of larynx Hep-2 in vitro and their corresponding mechanisms were investigated. Hep-2 cells were cultured with two kinds of selective cyclooxygenase-2 inhibitors (Sc-58125 and Celecoxib) at various concentrations for 24 h. Morphological changes were observed under the phase microscopy and the growth suppression was detected by using MTT colorimetric assay. Apoptotic DNA fragments were observed by agarose gel electrophoresis, and the cell cycle and apoptotic rate were detected by flow cytometry (FCM) respectively. Hep-2 cells became rounded and detached from the culture dish after being treated with Celecoxib for 24 h, however, they remained morphologically unchanged with Sc-58125. Sc-58125 could increase G 2 phase cells, whereas, Celecoxib rose G 1 phase cells. Both of the two effects were dose-dependent. Moreover, the Hep-2 cells cultured with 50 μmol/L and 100 μmol/L Celecoxib showed obvious apoptosis, with the nuclear DNA of cells exhibiting characteristic DNA ladder. So Sc-58125 could inhibit the proliferation of Hep-2 cells by altering the G 2 phase cells. However, Celecoxib had the same effect by changing the G 1 phase cells and inducing apoptosis at higher concentration.展开更多
Background: Primary non-hodgkin lymphoma of the larynx is a rare entity accounting for 1% of laryngeal tumors. Fewer than 100 cases have been reported in the literature. Case presentation: A 52-year-old man, presented...Background: Primary non-hodgkin lymphoma of the larynx is a rare entity accounting for 1% of laryngeal tumors. Fewer than 100 cases have been reported in the literature. Case presentation: A 52-year-old man, presented with a two-month history of dysphonia. Nasofibroscopy showed left submucosal bulging of the laryngeal supraglottic floor. Cervical computed tomography showed extensive left supraglottic mass, with partial lysis of the thyroid cartilage. Direct laryngoscopy showed left submucosal bulging of the supraglottic floor. Transmucosal biopsies were performed. Histological study concluded to the presence of a diffuse large-cell B lymphoma. The patient was treated with chemotherapy followed by external radiotherapy. Evolution was favourable. Conclusion: Although primary laryngeal non-hodgkin lymphoma is rare, it should be considered in the differential diagnosis of a mass in the neck region, especially in the supraglottic area. Direct laryngoscopy with biopsy makes the diagnosis. Treatment and prognosis depend on the stage and the grade of the lymphoma.展开更多
Tracheostomy is a well-established, commonly used surgical procedure, whose early and late complications are widely described in literature. Some of them remain still poorly known, though. One of these rare complicati...Tracheostomy is a well-established, commonly used surgical procedure, whose early and late complications are widely described in literature. Some of them remain still poorly known, though. One of these rare complications is a peculiar larynx-shaped reorganization of the tracheal rings and cricoid cartilage. This tracheal narrowing seems to be non- symptomatic and not life-threatening, at least as long as the reduction of the lumen is <50% - 75%. Such a finding has never been described so far in the literature, and should be kept in mind as one of late complication of tracheostomy.展开更多
Objective： To study the relationship between Survivin and VEGF proteins in a subgroup of patients with squarnous carcinoma of larynx. Methods： 108 cases of squamous carcinoma of larynx with clinical data were collec...Objective： To study the relationship between Survivin and VEGF proteins in a subgroup of patients with squarnous carcinoma of larynx. Methods： 108 cases of squamous carcinoma of larynx with clinical data were collected and expressions of Survivin and VEGF in peripheral blood were investigated by enzyme-linked immunosorbent assay （ELISA）. Results： Expressions of Survivin and VEGF were significantly associated with T stage, N stage and metastasis of squamous carcinoma of larynx. The patients with Survivin or VEGF over-expressions presented lower survival rate, respectively, as compared to those of low-expression （P 〈 0.05）. The survival rate in squamous carcinoma of larynx patients with Survivin and VEGF dual over-expressions was significantly lower than that of patients with dual low-expression （P 〈 0.05）. Multivariate analysis indicated that both Survivin and VEGF over-expressions in squamous carcinoma of larynx peripheral blood samples were strong independent factors of poor prognosis in squamous carcinoma of larynx patients. Conclusion： Survivin and VEGF over-expressions are independent prognostic factors for the patients with squamous carcinoma of larynx. These results also suggest that peripheral blood Survivin and VEGF expressions are valuable prognostic markers for prognosis prediction in squamous carcinoma of larynx patients.展开更多
An uncommon clinical entity of papillary cystadenoma of the larynx in a lady of 37-year-old is presented. The diagnosis after clinical examination was achieved by video-stroboscopy, CT scan of the neck, biopsy and his...An uncommon clinical entity of papillary cystadenoma of the larynx in a lady of 37-year-old is presented. The diagnosis after clinical examination was achieved by video-stroboscopy, CT scan of the neck, biopsy and histopathological examination. This case study emphasizes the importance of recognition of this lesion by the clinician as the differential diagnosis includes lesions with similar clinical appearance.展开更多
Background: Historically frenotomy was performed at newborn babies’ baptism for healthy breast-feeding over many centuries. Although it was necessary for nursing babies, its application was denied subjectively withou...Background: Historically frenotomy was performed at newborn babies’ baptism for healthy breast-feeding over many centuries. Although it was necessary for nursing babies, its application was denied subjectively without clinical observation since the early 20th century. As a result solutions for breastfeeding and breast problems are confused now. Methods: We studied changes in breastfeeding and mothers’ breasts before and one month after the surgeries for ADEL by standards for healthy breastfeeding and breasts. Results: With regard to suckling, before the surgeries 24% of babies opened their eyes during breastfeeding, while after surgeries 76% opened eyes while nursing. 30% of the babies latched onto the mother’s breast with a wide-open mouth. After surgeries, 84% properly latched on. 73% of the babies had calluses on the upper lip before surgeries, and no calluses were observed after surgeries. 27% of babies before surgeries moved the jaws during breast-feeding, but after surgeries 88% moved the jaws while nursing. White debris was on the dorsum tongue in 70% of babies prior to surgeries. After surgeries, 22% were with debris. 67% of mothers experienced nipple pain before their babies’ surgeries while 6% had pain after the surgeries. Flattened nipples were observed in 55% of mothers before the infants’ surgeries, 7% after surgeries. 23% of mothers had breast pain before the surgeries, and 4% had breast pain after the surgeries. Mastitis was also reduced from 9% to 1% after surgeries. 73% of women had palpable breast masses, and after the surgeries 25% had palpable masses. Summary: Remarkable improvements in breastfeeding and in women’s breasts were achieved after their infants underwent operations for ADEL. These results indicate the necessity of surgical interventions in babies with ADEL for healthy breastfeeding and breasts (279).展开更多
Introduction: Foreign bodies of the larynx are serious. They can be immediately life-threatening. The aim of this study was to report the epidemiological and clinical features that characterize this affection. Materia...Introduction: Foreign bodies of the larynx are serious. They can be immediately life-threatening. The aim of this study was to report the epidemiological and clinical features that characterize this affection. Material and method: We retrospectively reviewed the clinical records of patients admitted to foreign bodies of the lower airways in the Otorhinolaryngology (ORL) department of the University Hospital-Yalgado Ouedraogo (UH-YO) from 2008 to 2012. Results: Seventeen (17) foreign body records were compiled on a group of 76 foreign bodies of the lower airways. The average age was 5 years. Patients ranged in age from 6 months to 35 years with a sex ratio of 1.4. The call signs were the penetration syndrome that was found in 4 cases (23.5%), laryngeal dyspnea was found in 8 cases (47.05%) with stage II to III and dysphonia 10 cases (58.8%). The extraction was done endoscopically in all patients, and a tracheostomy was made in 2 cases (11.7%). A death was noted in 1 case (5.9%). Conclusion: The laryngeal foreign bodies are common and maintain their classical gravity. It should be thought about in front of any dyspnea associated with dysphonia in children previously healthy. The prevention is the key weapon in our context.展开更多
Objective: To diagnose early malignant laryngeal lesions by electronic laryngoscopy combined with narrow-band imaging (NBI) and observe its effect. Methods: The observation was started in January 2019 and ended in Aug...Objective: To diagnose early malignant laryngeal lesions by electronic laryngoscopy combined with narrow-band imaging (NBI) and observe its effect. Methods: The observation was started in January 2019 and ended in August 2021, among which 100 patients were suspected of laryngeal diseases. The above patients were diagnosed by enhanced CT, white light electronic laryngoscopy and NBI combined with electronic laryngoscopy, and the effects of the three diagnostic methods were compared. Results: The diagnostic accuracy of enhanced CT, NBI and white light mode was 78.68%, 100% and 88.52% (χ210.562, P 0.025), and the results were different. Conclusion: The combination of electronic laryngoscope and narrow-band imaging is effective and can be popularized.展开更多
Granular cell tumors, also called Abrikossoff tumors, are benign, slowly growing neoplasms. They may occur anywhere in the body, but head and neck accounts to 45% - 65% of these cases. The most common site is the tong...Granular cell tumors, also called Abrikossoff tumors, are benign, slowly growing neoplasms. They may occur anywhere in the body, but head and neck accounts to 45% - 65% of these cases. The most common site is the tongue. Larynx is relatively an uncommon location for these tumours, accounting for approximately three to 10 per cent of the reported cases. Laryngeal granular cell tumour is extremely rare accounting for only 19 reported cases under the age of 17 years. As many as 10% of patients experience multifocal synchronous or metachronous tumors. We present a rare case report of granular cell tumour of the larynx.展开更多
Extramedullary plasmacytoma of the larynx is rare, especially when coexisted with squamous cell carcinoma in situ. We report a 56-year-old woman with hoarseness for 6 months and dysphonia for a week. Fiberoptic laryng...Extramedullary plasmacytoma of the larynx is rare, especially when coexisted with squamous cell carcinoma in situ. We report a 56-year-old woman with hoarseness for 6 months and dysphonia for a week. Fiberoptic laryngoscopic examination showed a red, smooth-surface swelling in the submucous region of the left ventricle and ventricular band of the larynx. The patient underwent vertical laryngectomy and modified left neck dissection. Postoperative pathologic examination revealed coexisting plasmacytoma and carcinoma in situ. Bone marrow biopsy and systemic radiogram showed no positive findings. The hepatic and renal functions were normal. Monoclonal immunoglobulin light chain of type kappa was detected in urine. Hence, a laryngeal extramedullary plasmacytoma with carcinoma in situ was diagnosed. No recurrence or progression was observed during a 2-year follow-up. Here, we discussed the risk factors, diagnosis, and therapy for this rare disease.展开更多
文摘Primary malignant melanoma of the larynx is extremely rare.This paper reports a case of a patient with primary malignant melanoma of the larynx.Preoperative laryngoscopy revealed a cauliflower-like mass in the supraglottic region,and a CT scan of the pharynx suggested laryngeal cancer with cervical lymph node metastasis.The patient underwent a total laryngectomy with lymph node dissection,and postoperative pathology confirmed a malignant melanoma in the supraglottic region of the larynx.
文摘Objective: Laryngeal cancer is an important oncologic entity, whose prognosis depends on establishing appropriate preventive and diagnostic measures, especially in populations at higher risk.Methods: Epidemiologic information including worldwide incidence, prevalence, burden of health loss(disability-adjusted life year;DALYs) and mortality of larynx cancer was obtained from the Global Health Data Exchange(GHDx) database.Results: The current incidence, prevalence and mortality of laryngeal cancer are estimated at 2.76 cases/year per 100,000 inhabitants, 14.33 cases/year per 100,000 inhabitants and 1.66 deaths/year per 100,000 inhabitants,respectively, averaging 3.28 million DALYs each year. Incidence and prevalence have increased by 12% and 24%,respectively during the past 3 decades, whilst mortality has declined by around 5%. The epidemiologic burden of this malignancy is approximately 5-fold higher in males and increases in parallel with ageing, peaking after 65 years of age. Both incidence and mortality rates are higher in Europe and lower in Africa, but the ratio between deaths and incidence is the highest in Africa. Incidence has gradually declined in Europe during the past 3 decades, whilst it has increased in South-East Asia and Western Pacific. Cigarette smoking and alcohol abuse contribute for about 90% of overall worldwide mortality for laryngeal cancer.Conclusions: Laryngeal cancer still poses a high clinical and societal burden, with an escalating temporal trend not expected to reverse soon.
文摘BACKGROUND Collision carcinoma is rare in clinical practice, especially in the head and neck region. In this paper, we report a case of squamous cell carcinoma(SCC) and neuroendocrine carcinoma(NEC) colliding in the larynx and review 12 cases of collision carcinoma in the head and neck to further understand collision carcinoma, including its definition, diagnosis, and treatment.CASE SUMMARY A 61-year-old man presented with a 1-year history of hoarseness. Contrastenhanced magnetic resonance imaging of the larynx revealed that the right vocal cord had a nodule-like thickening with obvious enhancement. Laryngoscopy revealed a neoplasm on the right vocal cord, and a malignant tumor was initially considered. A frozen section of right vocal cord was performed under general anesthesia. The pathological result showed a malignant tumor in the right vocal cord. The tumor was excised with a CO_2 laser(Vc type). Routine postoperative pathology showed moderately differentiated SCC with small cell NEC in the right vocal cord. No metastatic lymph nodes or distant metastases were found on postoperative positron emission tomography/computed tomography. Because of the coexistence of SCC and NEC, the patient received adjuvant chemotherapy and radiotherapy. The patient was followed for 8 mo, and no recurrence or distant metastasis was found.CONCLUSION The treatment of collision carcinoma in the head and neck region is uncertain due to the small number of cases.
文摘BACKGROUND Chondrosarcomas of the larynx are malignant tumours that most commonly originate from the hyaline cartilage.Chondrosarcoma of the larynx,the most common type of low-grade tumour,accounts for 1%of all laryngeal neoplasms.CASE SUMMARY We present the case of a 60-year-old female patient who developed progressive hoarseness and shortness of breath over a 2-mo period.The patient had undergone resection of a laryngeal tumour 14 years before the aforementioned symptoms occurred,and histopathological analysis indicated that it was a chondroma.During the assessment of the patient,a submucosal,oval-shaped tumour was detected that was predominantly located on the left side of the larynx and was approximately 6 cm in size.The decision to perform left partial vertical laryngectomy was made.A pathohistological diagnosis of low-grade chondrosarcoma was made.Considering the results of pathohistological analysis and the positive margins of the resection,a total laryngectomy was performed.During the 12-mo follow-up,no local relapse or regional or distant metastases was detected.CONCLUSION Chondrosarcoma of the larynx must be considered in the differential diagnosis of laryngeal submucosal tumours.It is crucial to carefully sample of tumour tissue,differentiate chondroma and chondrosarcoma,and consider the possibility of malignant changes from chondroma to chondrosarcoma.
文摘Gout is a metabolic disorder that is characterized by a deposition of monosodium urate crystals in the joint or soft tissue. Gout manifestations in head and neck region are rare, and larynx is an infrequently affected location. We recently managed a case of a gouty tophus over the larynx. A 65-year-old male with a long history of gout without medical control. He has suffered from increasing hoarseness for six months. Laryngoscopy revealed a mass lesion over the right vocal process region without vocal paralysis. Laryngo-micro-surgery biopsy was taken, and pathology confirmed laryngeal gouty tophus without evidence of malignancy.
文摘This article deals with a treatment of acute diseases of pharynx and larynx with bloodpricking therapy, in this treatment, a group of 79 patients accepted the treatment with this therapy.The therapy contains mainly two methods: Acupoint pricking and local scattered pricking. A good result is achieved. It proves that blood-pricking method can replace the antibiotics and alleviate the sufferer’s pain and economic burden. It is simple and easy to carry out, thus it can be spread extensively.
文摘From July 1969 to November 1991, 4 patients with primary malignant lymphoma of the larynx were treated.One case was received radiotherapy and followed- up survey for 20 years being healthy, 3 case were received radiotherapy and chemotherapy. A total dose of 45-60 Gy was delivered. The disease can be classified four clinical types, (1) localized laryngeal lymphoma; (2) cephalocevical and larynx lymphoma; (3) laryngeal pieces region lymphoma; and (4) laryngeal pieces wildly spreaded lymphoma. The favorable prognostic factors were clinical course, clinical staging and the mode of treatment.
基金This project was supported by the Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions of MOE of China
文摘Summary: The inhibitory effects of two kinds of selective cyclooxygenase-2 inhibitors on the proliferation of human carcinoma of larynx Hep-2 in vitro and their corresponding mechanisms were investigated. Hep-2 cells were cultured with two kinds of selective cyclooxygenase-2 inhibitors (Sc-58125 and Celecoxib) at various concentrations for 24 h. Morphological changes were observed under the phase microscopy and the growth suppression was detected by using MTT colorimetric assay. Apoptotic DNA fragments were observed by agarose gel electrophoresis, and the cell cycle and apoptotic rate were detected by flow cytometry (FCM) respectively. Hep-2 cells became rounded and detached from the culture dish after being treated with Celecoxib for 24 h, however, they remained morphologically unchanged with Sc-58125. Sc-58125 could increase G 2 phase cells, whereas, Celecoxib rose G 1 phase cells. Both of the two effects were dose-dependent. Moreover, the Hep-2 cells cultured with 50 μmol/L and 100 μmol/L Celecoxib showed obvious apoptosis, with the nuclear DNA of cells exhibiting characteristic DNA ladder. So Sc-58125 could inhibit the proliferation of Hep-2 cells by altering the G 2 phase cells. However, Celecoxib had the same effect by changing the G 1 phase cells and inducing apoptosis at higher concentration.
文摘Background: Primary non-hodgkin lymphoma of the larynx is a rare entity accounting for 1% of laryngeal tumors. Fewer than 100 cases have been reported in the literature. Case presentation: A 52-year-old man, presented with a two-month history of dysphonia. Nasofibroscopy showed left submucosal bulging of the laryngeal supraglottic floor. Cervical computed tomography showed extensive left supraglottic mass, with partial lysis of the thyroid cartilage. Direct laryngoscopy showed left submucosal bulging of the supraglottic floor. Transmucosal biopsies were performed. Histological study concluded to the presence of a diffuse large-cell B lymphoma. The patient was treated with chemotherapy followed by external radiotherapy. Evolution was favourable. Conclusion: Although primary laryngeal non-hodgkin lymphoma is rare, it should be considered in the differential diagnosis of a mass in the neck region, especially in the supraglottic area. Direct laryngoscopy with biopsy makes the diagnosis. Treatment and prognosis depend on the stage and the grade of the lymphoma.
文摘Tracheostomy is a well-established, commonly used surgical procedure, whose early and late complications are widely described in literature. Some of them remain still poorly known, though. One of these rare complications is a peculiar larynx-shaped reorganization of the tracheal rings and cricoid cartilage. This tracheal narrowing seems to be non- symptomatic and not life-threatening, at least as long as the reduction of the lumen is <50% - 75%. Such a finding has never been described so far in the literature, and should be kept in mind as one of late complication of tracheostomy.
基金the grants from the National Outstanding Young Scien- tist Foundation of China (No. 39925035) the National Natural Science Foundations of China (No. 3967078 and No. 30070809)
文摘Objective： To study the relationship between Survivin and VEGF proteins in a subgroup of patients with squarnous carcinoma of larynx. Methods： 108 cases of squamous carcinoma of larynx with clinical data were collected and expressions of Survivin and VEGF in peripheral blood were investigated by enzyme-linked immunosorbent assay （ELISA）. Results： Expressions of Survivin and VEGF were significantly associated with T stage, N stage and metastasis of squamous carcinoma of larynx. The patients with Survivin or VEGF over-expressions presented lower survival rate, respectively, as compared to those of low-expression （P 〈 0.05）. The survival rate in squamous carcinoma of larynx patients with Survivin and VEGF dual over-expressions was significantly lower than that of patients with dual low-expression （P 〈 0.05）. Multivariate analysis indicated that both Survivin and VEGF over-expressions in squamous carcinoma of larynx peripheral blood samples were strong independent factors of poor prognosis in squamous carcinoma of larynx patients. Conclusion： Survivin and VEGF over-expressions are independent prognostic factors for the patients with squamous carcinoma of larynx. These results also suggest that peripheral blood Survivin and VEGF expressions are valuable prognostic markers for prognosis prediction in squamous carcinoma of larynx patients.
文摘An uncommon clinical entity of papillary cystadenoma of the larynx in a lady of 37-year-old is presented. The diagnosis after clinical examination was achieved by video-stroboscopy, CT scan of the neck, biopsy and histopathological examination. This case study emphasizes the importance of recognition of this lesion by the clinician as the differential diagnosis includes lesions with similar clinical appearance.
文摘Background: Historically frenotomy was performed at newborn babies’ baptism for healthy breast-feeding over many centuries. Although it was necessary for nursing babies, its application was denied subjectively without clinical observation since the early 20th century. As a result solutions for breastfeeding and breast problems are confused now. Methods: We studied changes in breastfeeding and mothers’ breasts before and one month after the surgeries for ADEL by standards for healthy breastfeeding and breasts. Results: With regard to suckling, before the surgeries 24% of babies opened their eyes during breastfeeding, while after surgeries 76% opened eyes while nursing. 30% of the babies latched onto the mother’s breast with a wide-open mouth. After surgeries, 84% properly latched on. 73% of the babies had calluses on the upper lip before surgeries, and no calluses were observed after surgeries. 27% of babies before surgeries moved the jaws during breast-feeding, but after surgeries 88% moved the jaws while nursing. White debris was on the dorsum tongue in 70% of babies prior to surgeries. After surgeries, 22% were with debris. 67% of mothers experienced nipple pain before their babies’ surgeries while 6% had pain after the surgeries. Flattened nipples were observed in 55% of mothers before the infants’ surgeries, 7% after surgeries. 23% of mothers had breast pain before the surgeries, and 4% had breast pain after the surgeries. Mastitis was also reduced from 9% to 1% after surgeries. 73% of women had palpable breast masses, and after the surgeries 25% had palpable masses. Summary: Remarkable improvements in breastfeeding and in women’s breasts were achieved after their infants underwent operations for ADEL. These results indicate the necessity of surgical interventions in babies with ADEL for healthy breastfeeding and breasts (279).
文摘Introduction: Foreign bodies of the larynx are serious. They can be immediately life-threatening. The aim of this study was to report the epidemiological and clinical features that characterize this affection. Material and method: We retrospectively reviewed the clinical records of patients admitted to foreign bodies of the lower airways in the Otorhinolaryngology (ORL) department of the University Hospital-Yalgado Ouedraogo (UH-YO) from 2008 to 2012. Results: Seventeen (17) foreign body records were compiled on a group of 76 foreign bodies of the lower airways. The average age was 5 years. Patients ranged in age from 6 months to 35 years with a sex ratio of 1.4. The call signs were the penetration syndrome that was found in 4 cases (23.5%), laryngeal dyspnea was found in 8 cases (47.05%) with stage II to III and dysphonia 10 cases (58.8%). The extraction was done endoscopically in all patients, and a tracheostomy was made in 2 cases (11.7%). A death was noted in 1 case (5.9%). Conclusion: The laryngeal foreign bodies are common and maintain their classical gravity. It should be thought about in front of any dyspnea associated with dysphonia in children previously healthy. The prevention is the key weapon in our context.
文摘Objective: To diagnose early malignant laryngeal lesions by electronic laryngoscopy combined with narrow-band imaging (NBI) and observe its effect. Methods: The observation was started in January 2019 and ended in August 2021, among which 100 patients were suspected of laryngeal diseases. The above patients were diagnosed by enhanced CT, white light electronic laryngoscopy and NBI combined with electronic laryngoscopy, and the effects of the three diagnostic methods were compared. Results: The diagnostic accuracy of enhanced CT, NBI and white light mode was 78.68%, 100% and 88.52% (χ210.562, P 0.025), and the results were different. Conclusion: The combination of electronic laryngoscope and narrow-band imaging is effective and can be popularized.
文摘Granular cell tumors, also called Abrikossoff tumors, are benign, slowly growing neoplasms. They may occur anywhere in the body, but head and neck accounts to 45% - 65% of these cases. The most common site is the tongue. Larynx is relatively an uncommon location for these tumours, accounting for approximately three to 10 per cent of the reported cases. Laryngeal granular cell tumour is extremely rare accounting for only 19 reported cases under the age of 17 years. As many as 10% of patients experience multifocal synchronous or metachronous tumors. We present a rare case report of granular cell tumour of the larynx.
文摘Extramedullary plasmacytoma of the larynx is rare, especially when coexisted with squamous cell carcinoma in situ. We report a 56-year-old woman with hoarseness for 6 months and dysphonia for a week. Fiberoptic laryngoscopic examination showed a red, smooth-surface swelling in the submucous region of the left ventricle and ventricular band of the larynx. The patient underwent vertical laryngectomy and modified left neck dissection. Postoperative pathologic examination revealed coexisting plasmacytoma and carcinoma in situ. Bone marrow biopsy and systemic radiogram showed no positive findings. The hepatic and renal functions were normal. Monoclonal immunoglobulin light chain of type kappa was detected in urine. Hence, a laryngeal extramedullary plasmacytoma with carcinoma in situ was diagnosed. No recurrence or progression was observed during a 2-year follow-up. Here, we discussed the risk factors, diagnosis, and therapy for this rare disease.
