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A physics knowledge-based surrogate model framework for timedependent slope deformation:Considering water effect and sliding states
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作者 Wenyu Zhuang Yaoru Liu +3 位作者 Kai Zhang Qingchao Lyu Shaokang Hou Qiang Yang 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第9期5416-5436,共21页
The surrogate model serves as an efficient simulation tool during the slope parameter inversion process.However,the creep constitutive model integrated with dynamic damage evolution poses challenges in development of ... The surrogate model serves as an efficient simulation tool during the slope parameter inversion process.However,the creep constitutive model integrated with dynamic damage evolution poses challenges in development of the required surrogate model.In this study,a novel physics knowledge-based surrogate model framework is proposed.In this framework,a Transformer module is employed to capture straindriven softening-hardening physical mechanisms.Positional encoding and self-attention are utilized to transform the constitutive parameters associated with shear strain,which are not directly time-related,into intermediate latent features for physical loss calculation.Next,a multi-layer stacked GRU(gated recurrent unit)network is built to provide input interfaces for time-dependent intermediate latent features,hydraulic boundary conditions,and water-rock interaction degradation equations,with static parameters introduced via external fully-connected layers.Finally,a combined loss function is constructed to facilitate the collaborative training of physical and data loss,introducing time-dependent weight adjustments to focus the surrogate model on accurate deformation predictions during critical phases.Based on the deformation of a reservoir bank landslide triggered by impoundment and subsequent restabilization,an elasto-viscoplastic constitutive model that considers water effect and sliding state dependencies is developed to validate the proposed surrogate model framework.The results indicate that the framework exhibits good performance in capturing physical mechanisms and predicting creep behavior,reducing errors by about 30 times compared to baseline models such as GRU and LSTM(long short-term memory),meeting the precision requirements for parameter inversion.Ablation experiments also confirmed the effectiveness of the framework.This framework can also serve as a reference for constructing other creep surrogate models that involve non-time-related across dimensions. 展开更多
关键词 Reservoir bank slope Time-dependent deformation Elasto-viscoplastic constitutive model Physics knowledge-based deep learning Surrogate model
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Gaps in science-policy interface:textual analysis of scientific insights overlooked by policies during COVID-19
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作者 Chao Ren Menghui Yang 《Journal of Data and Information Science》 2025年第3期92-118,共27页
Purpose:Policies have often,albeit inadvertently,overlooked certain scientific insights,especially in the handling of complex events.This study aims to systematically uncover and evaluate pivotal scientific insights t... Purpose:Policies have often,albeit inadvertently,overlooked certain scientific insights,especially in the handling of complex events.This study aims to systematically uncover and evaluate pivotal scientific insights that have been underrepresented in policy documents by leveraging extensive datasets from policy texts and scholarly publications.Design/methodology/approach:This article introduces a research framework aimed at excavating scientific insights that have been overlooked by policy,encompassing four integral parts:data acquisition and preprocessing,the identification of overlooked content through thematic analysis,the discovery of overlooked content via keyword analysis,and a comprehensive analysis and discussion of the overlooked content.Leveraging this framework,the research conducts an in-depth exploration of the scientific content overlooked by policies during the COVID-19 pandemic.Findings:During the COVID-19 pandemic,scientific information in four domains was overlooked by policy:psychological state of the populace,environmental issues,the role of computer technology,and public relations.These findings indicate a systematic underrepresentation of important scientific insights in policy.Research limitations:This study is subject to two key limitations.Firstly,the text analysis method—relying on pre-extracted keywords and thematic structures—may not fully capture the nuanced context and complexity of scientific insights in policy documents.Secondly,the focus on a limited set of case studies restricts the broader applicability of the conclusions across diverse situations.Practical implications:The study introduces a quantitative framework using text analysis to identify overlooked scientific content in policy,bridging the gap between science and policy.It also highlights overlooked scientific information during COVID-19,promoting more evidence-based and robust policies through improved science-policy integration.Originality/value:This paper provides new ideas and methods for excavating scientific information that has been overlooked by policy,further deepens the understanding of the interaction between policy and science during the COVID-19 period,and lays the foundation for the more rational use of scientific information in policy-making. 展开更多
关键词 Science-policy interface COVID-19 policy Overlooked science Text analysis
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Innovation and Development Policy(中文名:《创新与发展政策(英文)》)征稿启事
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《科研管理》 北大核心 2026年第1期F0004-F0004,共1页
Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊... Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。 展开更多
关键词 创新与发展政策 Innovation and Development policy
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Chengdu’s Real Estate Market(2019-2024):An Integrated Framework for Data-Driven Insights and Policy Analysis
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作者 HU Xiao WU Jing +1 位作者 WANG Yan JIANG Xinyi 《Cultural and Religious Studies》 2026年第1期26-42,共17页
This study integrates multiple sources of data(transaction data,policy text,public opinion data)with visualization techniques(such as heat maps,time-series trend charts,3D building brochures)to construct an analysis f... This study integrates multiple sources of data(transaction data,policy text,public opinion data)with visualization techniques(such as heat maps,time-series trend charts,3D building brochures)to construct an analysis framework for the Chengdu real estate market.By using the Adaptive Neuro-Fuzzy Inference System(ANFIS)prediction model,spatial GIS(Geographic Information System analysis)analysis,and interactive dashboards,this study reveals market differentiation,policy impacts,and changes in demand structure,thereby providing decision support for the government,enterprises,and homebuyers. 展开更多
关键词 Chengdu City real estate market data-driven insights policy analysis
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Strategies and Policies for Developing Rural “Local Specialty Products” in Ecological Conservation Areas
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作者 Wei Houkai Hu Lingxiao 《Contemporary Social Sciences》 2026年第1期90-103,共14页
The promotion of rural revitalization within the ecological conservation areas(“ECAs”) requires a careful balance between ecological protection and economic development and should be guided by the principle of ecolo... The promotion of rural revitalization within the ecological conservation areas(“ECAs”) requires a careful balance between ecological protection and economic development and should be guided by the principle of ecological priority. The cultivation of rural “Local Specialty Products”(“LSPs”) under a green-development framework aligns with the functional positioning of these areas, drives the revitalization of rural industries, and constitutes a fundamental strategy for addressing the unique challenges they face. Although ECAs possess inherent advantages in terms of developing LSPs, they are also confronted by multiple constraints. Accordingly, we propose development objectives that emphasize(a) driving rural industrial prosperity,(b) enhancing the appeal of agricultural heritage, and(c) ensuring inclusive prosperity in the farming communities. In selecting pathways for growth, priority should be given to improving the quality of products, fostering distinctiveness of the technologies, nurturing cultural identities, and upholding the principle of common prosperity. From a policy standpoint, the development of rural LSPs should be recognized as a key lever for advancing the comprehensiveness of rural revitalization in the ECAs. We recommend a set of supportive measures—namely, reinforcing the guidance for spatial planning, integrating the consolidation of factor inputs, and ensuring the robustness of organizational guarantees—to facilitate the high-quality development of LSPs in these areas. 展开更多
关键词 ecological conservation areas areas rural local specialty products(LSPs) development objectives PATHWAYS policy support
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基于Off-policy Q-学习的时延系统线性二次型跟踪控制算法
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作者 刘文 蔚保国 +1 位作者 郝菁 王卿 《无线电工程》 2026年第1期166-176,共11页
对被控系统数学模型参数未知的线性离散时间系统,同时考虑工业过程中数据存在控制输入时间延时的问题,提出一种数据驱动算法,解决时延系统线性二次型跟踪(Linear Quadratic Tracking,LQT)控制问题。通过对时延系统控制问题的描述,构建... 对被控系统数学模型参数未知的线性离散时间系统,同时考虑工业过程中数据存在控制输入时间延时的问题,提出一种数据驱动算法,解决时延系统线性二次型跟踪(Linear Quadratic Tracking,LQT)控制问题。通过对时延系统控制问题的描述,构建了基于模型驱动的强化学习算法框架,在此基础上为了避免使用数学模型参数和状态数据信息,引入Smith预估器,提出了基于On-policy Q-学习的时延系统LQT控制算法。考虑On-policy Q-学习算法中探测噪声对学习结果的影响,进一步采用Off-policy算法解决时延系统LQT控制问题。在此基础上改进Q-学习算法中使用的Bellman方程,提出数据驱动的Off-policy Q-学习算法,该算法不受探测噪声的影响,求解得到的解是无偏差的。理论分析和仿真实验表明,在避免依赖系统数学模型参数和状态数据的前提下,有效实现了时延系统的跟踪控制。 展开更多
关键词 时延系统 强化学习 Off-policy 数据驱动 输出反馈
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Knowledge-Based Classification in Automated Soil Mapping 被引量:10
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作者 ZHOU BIN and WANG RENCHAOInstitute of Agricultural Remote Sensing and Information Technology Application, Zhejiang University, Hangzhou 310029 (China) 《Pedosphere》 SCIE CAS CSCD 2003年第3期209-218,共10页
A machine-learning approach was developed for automated building of knowledgebases for soil resources mapping by using a classification tree to generate knowledge from trainingdata. With this method, building a knowle... A machine-learning approach was developed for automated building of knowledgebases for soil resources mapping by using a classification tree to generate knowledge from trainingdata. With this method, building a knowledge base for automated soil mapping was easier than usingthe conventional knowledge acquisition approach. The knowledge base built by classification tree wasused by the knowledge classifier to perform the soil type classification of Longyou County,Zhejiang Province, China using Landsat TM bi-temporal images and CIS data. To evaluate theperformance of the resultant knowledge bases, the classification results were compared to existingsoil map based on a field survey. The accuracy assessment and analysis of the resultant soil mapssuggested that the knowledge bases built by the machine-learning method was of good quality formapping distribution model of soil classes over the study area. 展开更多
关键词 CLASSIFICATION classification tree knowledge-based rule extracting soilmapping
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Knowledge-based bridge detection from SAR images 被引量:5
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作者 Wang Wenguang Sun Jinping +1 位作者 Hu Rui Mao Shiyi 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第5期929-936,共8页
Automatic bridge detection is an important application of SAR images.Differed from the classical CFAR method,a new knowledge-based bridge detection approach is proposed.The method not only uses the backscattering inte... Automatic bridge detection is an important application of SAR images.Differed from the classical CFAR method,a new knowledge-based bridge detection approach is proposed.The method not only uses the backscattering intensity difference between targets and background but also applies the contextual information and spatial relationship between objects.According to bridges'special characteristics and scattering properties in SAR images,the new knowledge-based method includes three processes:river segmentation,potential bridge areas detection and bridge discrimination.The application to AIRSAR data shows that the new method is not sensitive to rivers'shape.Moreover,this method can detect bridges successfully when river segmentation is not very exact and is more robust than the radius projection method. 展开更多
关键词 knowledge-based bridge detection SAR contextual information mathematical morphology.
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New Knowledge-based Genetic Algorithm for Excavator Boom Structural Optimization 被引量:6
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作者 HUA Haiyan LIN Shuwen 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2014年第2期392-401,共10页
Due to the insufficiency of utilizing knowledge to guide the complex optimal searching, existing genetic algorithms fail to effectively solve excavator boom structural optimization problem. To improve the optimization... Due to the insufficiency of utilizing knowledge to guide the complex optimal searching, existing genetic algorithms fail to effectively solve excavator boom structural optimization problem. To improve the optimization efficiency and quality, a new knowledge-based real-coded genetic algorithm is proposed. A dual evolution mechanism combining knowledge evolution with genetic algorithm is established to extract, handle and utilize the shallow and deep implicit constraint knowledge to guide the optimal searching of genetic algorithm circularly. Based on this dual evolution mechanism, knowledge evolution and population evolution can be connected by knowledge influence operators to improve the conflgurability of knowledge and genetic operators. Then, the new knowledge-based selection operator, crossover operator and mutation operator are proposed to integrate the optimal process knowledge and domain culture to guide the excavator boom structural optimization. Eight kinds of testing algorithms, which include different genetic operators, arc taken as examples to solve the structural optimization of a medium-sized excavator boom. By comparing the results of optimization, it is shown that the algorithm including all the new knowledge-based genetic operators can more remarkably improve the evolutionary rate and searching ability than other testing algorithms, which demonstrates the effectiveness of knowledge for guiding optimal searching. The proposed knowledge-based genetic algorithm by combining multi-level knowledge evolution with numerical optimization provides a new effective method for solving the complex engineering optimization problem. 展开更多
关键词 boom structural optimization dual evolution mechanism knowledge-based genetic strategies deep implicit knowledge domain culture
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Structural Topology Design of Container Ship Based on Knowledge-Based Engineering and Level Set Method 被引量:5
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作者 崔进举 王德禹 史琪琪 《China Ocean Engineering》 SCIE EI CSCD 2015年第4期551-564,共14页
Knowledge-Based Engineering (KBE) is introduced into the ship structural design in this paper. From the implementation of KBE, the design solutions for both Rules Design Method (RDM) and Interpolation Design Meth... Knowledge-Based Engineering (KBE) is introduced into the ship structural design in this paper. From the implementation of KBE, the design solutions for both Rules Design Method (RDM) and Interpolation Design Method (IDM) are generated. The corresponding Finite Element (FE) models are generated. Topological design of the longitudinal structures is studied where the Gaussian Process (GP) is employed to build the surrogate model for FE analysis. Multi-objective optimization methods inspired by Pareto Front are used to reduce the design tank weight and outer surface area simultaneously. Additionally, an enhanced Level Set Method (LSM) which employs implicit algorithm is applied to the topological design of typical bracket plate which is used extensively in ship structures. Two different sets of boundary conditions are considered. The proposed methods show satisfactory efficiency and accuracy. 展开更多
关键词 knowledge-based Engineering (KBE) Level Set Method (LSM) Gaussian Process GP)
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FAULT DIAGNOSIS OF ROTATING MACHINERY USING KNOWLEDGE-BASED FUZZY NEURAL NETWORK 被引量:2
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作者 李如强 陈进 伍星 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2006年第1期99-108,共10页
A novel knowledge-based fuzzy neural network (KBFNN) for fault diagnosis is presented. Crude rules were extracted and the corresponding dependent factors and antecedent coverage factors were calculated firstly from ... A novel knowledge-based fuzzy neural network (KBFNN) for fault diagnosis is presented. Crude rules were extracted and the corresponding dependent factors and antecedent coverage factors were calculated firstly from the diagnostic sample based on rough sets theory. Then the number of rules was used to construct partially the structure of a fuzzy neural network and those factors were implemented as initial weights, with fuzzy output parameters being optimized by genetic algorithm. Such fuzzy neural network was called KBFNN. This KBFNN was utilized to identify typical faults of rotating machinery. Diagnostic results show that it has those merits of shorter training time and higher right diagnostic level compared to general fuzzy neural networks. 展开更多
关键词 rotating machinery fault diagnosis rough sets theory fuzzy sets theory generic algorithm knowledge-based fuzzy neural network
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Knowledge-based potentials in bioinformatics: From a physicist's viewpoint 被引量:1
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作者 郑伟谋 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第12期22-27,共6页
Biological raw data are growing exponentially, providing a large amount of information on what life is. It is believed that potential functions and the rules governing protein behaviors can be revealed from analysis o... Biological raw data are growing exponentially, providing a large amount of information on what life is. It is believed that potential functions and the rules governing protein behaviors can be revealed from analysis on known native structures of proteins. Many knowledge-based potentials for proteins have been proposed. Contrary to most existing review articles which mainly describe technical details and applications of various potential models, the main foci for the discussion here are ideas and concepts involving the construction of potentials, including the relation between free energy and energy, the additivity of potentials of mean force and some key issues in potential construction. Sequence analysis is briefly viewed from an energetic viewpoint. 展开更多
关键词 knowledge-based potentials for proteins protein native structures sequence signals
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A Knowledge-based System for the Analysis of the Ability of Paying back Loans 被引量:1
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作者 Zhu Ming(朱明) +1 位作者 Yang Baoan(杨保安) 《Journal of Donghua University(English Edition)》 EI CAS 2001年第1期123-126,共4页
This paper describes the development of a knowledgebased system (KBS) for determining whether or not, and under what conditions, a bank Ioan officer should grant a business loan to a company. The prototype system deve... This paper describes the development of a knowledgebased system (KBS) for determining whether or not, and under what conditions, a bank Ioan officer should grant a business loan to a company. The prototype system developed focuses on what is bank loans risks management, how to prevent risk by the analysis of the ability of paying back loans. The paper makes the structural analysis involved in the system's decision situation, the structured situation diagram or model, dependency diagram and the document needed by the KBS prototype system thus are developed. Through testing the samples from loan business, the quality for the analysis of the ability of paying back loans can be effectively evaluated by the KBS prototype system. 展开更多
关键词 knowledge-based SYSTEM (KBS) the KBS prototype system the ABILITY of paying BACK loans bank LOANS risk management.
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Integration of Decision-Support and Knowledge-Based Techniques in a Problem-Solving Strategy for Selection Problems 被引量:1
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作者 David McSherry(School of Information and Software Engineering,Faculty of Informatics, University of Ulster,Coleraine BT52 1SA, Northern Ireland) 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 1996年第2期35-54,共20页
The limitations of traditional approaches to selection problems are examined. A problemsolving strategy is presented in which decision-support and knowledge-based techniques play complementary roles. An approach to th... The limitations of traditional approaches to selection problems are examined. A problemsolving strategy is presented in which decision-support and knowledge-based techniques play complementary roles. An approach to the representation of knowledge to support the problem-solving strategy is presented which avoids commitment to a specific programming language or implementation environment. The problem of choosing a home is used to illustrate the representation of knowledge in a specific problem domain. Techniques for implementation of the problem-solving strategy are described. Knowledge elicitation techniques and their implementation in a development shell for application of the problem-solving strategy to any selection problem are also described. 展开更多
关键词 knowledge-based systems Decision-support systems Knowledge acquisition Multiple criteria decision making Operational research Analytic hierarchy process
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Yarn Quality Prediction and Diagnosis Based on Rough Set and Knowledge-Based Artificial Neural Network 被引量:1
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作者 杨建国 徐兰 +1 位作者 项前 刘彬 《Journal of Donghua University(English Edition)》 EI CAS 2014年第6期817-823,共7页
In the spinning process, some key process parameters( i. e.,raw material index inputs) have very strong relationship with the quality of finished products. The abnormal changes of these process parameters could result... In the spinning process, some key process parameters( i. e.,raw material index inputs) have very strong relationship with the quality of finished products. The abnormal changes of these process parameters could result in various categories of faulty products. In this paper, a hybrid learning-based model was developed for on-line intelligent monitoring and diagnosis of the spinning process. In the proposed model, a knowledge-based artificial neural network( KBANN) was developed for monitoring the spinning process and recognizing faulty quality categories of yarn. In addition,a rough set( RS)-based rule extraction approach named RSRule was developed to discover the causal relationship between textile parameters and yarn quality. These extracted rules were applied in diagnosis of the spinning process, provided guidelines on improving yarn quality,and were used to construct KBANN. Experiments show that the proposed model significantly improve the learning efficiency, and its prediction precision is improved by about 5. 4% compared with the BP neural network model. 展开更多
关键词 yarn quality prediction rough set(RS) knowledge discovery knowledge-based artificial neural network(KBANN)
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MY PERSONAL STUDY ON KNOWLEDGE-BASED ECONOMY 被引量:2
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作者 Deng Shuhui(Institute of Systems Science, the CAS) 《Bulletin of the Chinese Academy of Sciences》 1999年第2期119-120,共2页
The Financial Crisis in Asia is having a negative impacion the economic development of China, but it also enlightens us. It makes us consider and take measures to avoid such a crisis. I have put forward six measures, ... The Financial Crisis in Asia is having a negative impacion the economic development of China, but it also enlightens us. It makes us consider and take measures to avoid such a crisis. I have put forward six measures, one of which is to promote the transformation of S&T knowledge into productive forces. 展开更多
关键词 MODE MY PERSONAL STUDY ON knowledge-based ECONOMY
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Research on Knowledge-based Connecting Elements Modeling
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作者 HUANG Xiang, YAN Chong-jing (College of Mechanical and Electrical Engineering, Nanjing University o f Aeronautics and Astronautics, Nanjing 210016, China) 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第S1期162-163,共2页
Steps of manipulation is required to complete the m od eling of the connection elements such as bolt, pin and the like in commerce CAD system. It leads to low efficiency, difficulty to assure the relative position, im... Steps of manipulation is required to complete the m od eling of the connection elements such as bolt, pin and the like in commerce CAD system. It leads to low efficiency, difficulty to assure the relative position, impossibility to express rules and knowledge. Based on the inner character analy sis of interpart, detail modification and assembly relation of mechanical connec ting element, the idea, which extends the feature modeling of part to the interp art feature modeling for assembly purpose, is presented, and virtual part based connecting element modeling is proposed. Virtual part is a complement set of lo cal modification of part to be connected. In assembly modeling, base part is mod ified by Boolean operation between base part and virtual part. The modeling and assembly is finished just in one operation, at the same time the rules and knowl edge of the connection elements are encapsulated through virtual part. According to this mechanism, a knowledge-based connecting elements rapid design module i s developed on commerce software package UG with satisfying results. 展开更多
关键词 CAD knowledge-based engineering ASSEMBLY conn ecting element
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Optimizing the atom types of proteins through iterative knowledge-based potentials
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作者 汪心享 黄胜友 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第2期43-50,共8页
Knowledge-based scoring functions have been widely used for protein structure prediction, protein-small molecule, and protein-nucleic acid interactions, in which one critical step is to find an appropriate representat... Knowledge-based scoring functions have been widely used for protein structure prediction, protein-small molecule, and protein-nucleic acid interactions, in which one critical step is to find an appropriate representation of protein structures. A key issue is to determine the minimal protein representations, which is important not only for developing of scoring func- tions but also for understanding the physics of protein folding. Despite significant progresses in simplifying residues into alphabets, few studies have been done to address the optimal number of atom types for proteins. Here, we have investigated the atom typing issue by classifying the 167 heavy atoms of proteins through 11 schemes with 1 to 20 atom types based on their physicochemical and functional environments. For each atom typing scheme, a statistical mechanics-based iterative method was used to extract atomic distance-dependent potentials from protein structures. The atomic distance-dependent pair potentials for different schemes were illustrated by several typical atom pairs with different physicochemical proper- ties. The derived potentials were also evaluated on a high-resolution test set of 148 diverse proteins for native structure recognition. It was found that there was a crossover around the scheme of four atom types in terms of the success rate as a function of the number of atom types, which means that four atom types may be used when investigating the basic folding mechanism of proteins. However, it was revealed by a close examination of typical potentials that 14 atom types were needed to describe the protein interactions at atomic level. The present study will be beneficial for the development of protein related scoring functions and the understanding of folding mechanisms. 展开更多
关键词 atom types knowledge-based potentials statistical mechanics ITERATION
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A knowledge-based decision support system for engineering design
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作者 JIANG Hua, GAO Guo-an (Advanced Manufacturing Technology Center, Harbin Institute of Technology, Harbin 150001, China) 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2000年第S1期41-44,共4页
A knowledge-based decision supporting system, used for engineering design is introduced by describing the architecture, function, workflow of the system and its way of implementation. Based upon information composed o... A knowledge-based decision supporting system, used for engineering design is introduced by describing the architecture, function, workflow of the system and its way of implementation. Based upon information composed of knowledge, models, data, cases, methods, etc, the system is designed to use such methods as knowledge-based reasoning, case-based reasoning, and multi-criteria evaluation techniques to provide effective tools to support the decision-making process. 展开更多
关键词 intelligent SUPPORTING SYSTEM knowledge-based REASONING multiple CRITERIA DECISION evaluation support SYSTEM
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A novel knowledge-based potential for RNA 3D structure evaluation
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作者 Yi Yang Qi Gu +2 位作者 Ben-Gong Zhang Ya-Zhou Shi Zhi-Gang Shao 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第3期526-533,共8页
Ribonucleic acids(RNAs)play a vital role in biology,and knowledge of their three-dimensional(3D)structure is required to understand their biological functions.Recently structural prediction methods have been developed... Ribonucleic acids(RNAs)play a vital role in biology,and knowledge of their three-dimensional(3D)structure is required to understand their biological functions.Recently structural prediction methods have been developed to address this issue,but a series of RNA 3D structures are generally predicted by most existing methods.Therefore,the evaluation of the predicted structures is generally indispensable.Although several methods have been proposed to assess RNA 3D structures,the existing methods are not precise enough.In this work,a new all-atom knowledge-based potential is developed for more accurately evaluating RNA 3D structures.The potential not only includes local and nonlocal interactions but also fully considers the specificity of each RNA by introducing a retraining mechanism.Based on extensive test sets generated from independent methods,the proposed potential correctly distinguished the native state and ranked near-native conformations to effectively select the best.Furthermore,the proposed potential precisely captured RNA structural features such as base-stacking and base-pairing.Comparisons with existing potential methods show that the proposed potential is very reliable and accurate in RNA 3D structure evaluation. 展开更多
关键词 RNA 3D structure evaluation knowledge-based potential
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